Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging. Open Access

Naganawa S, Nakane T, Kawai H, Taoka T

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.11

2019年　最新医療機器の動向を探る　CTおよびMRIなどの画像診断機器の最新潮流ならびに今後のあり方

長縄慎二

医療機器システム白書 page： 14-17 2018.11

Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer Open Access

Yamada Takehiro, Ishihara Shunichi, Kawai Michiyasu, Itoh Yoshiyuki, Naganawa Shinji, Ikeda Mitsuru

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 487-496 2018.11

画像診断レポート未読問題について Reviewed

長縄慎二

健康文化 Vol. 53 ( - ) page： 138 - 142 2018.11

第三次人工知能ブーム？ Reviewed

長縄慎二

健康文化 Vol. 53 ( - ) page： 1 - 2 2018.11

Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

Sugimoto S, Yoshida T, Teranishi M, Kobayashi M, Shimono M, Naganawa S, Sone M

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology Vol. 39 ( 10 ) page： 1229-1234 2018.10

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study. Reviewed International journal Open Access

Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue

Frontiers in aging neuroscience Vol. 10 page： 304 - 304 2018.10

Language：English Publishing type：Research paper (scientific journal)

Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of 18F-THK5351 and resting state network (RSN) disruption in patients with early AD and healthy controls. Methods: We enrolled 23 11C-Pittsburgh compound B (PiB)-positive patients with early AD and 24 11C-PiB-negative participants as healthy controls. All participants underwent resting state functional MRI and 18F-THK5351 PET scans. We used scaled subprofile modeling/principal component analysis (SSM/PCA) to reduce the complexity of multivariate data and to identify patterns that exhibited the largest statistical effects (variances) in THK5351 concentration in AD and healthy controls. Findings: SSM/PCA identified a significant spatial THK5351 pattern composed by mainly three clusters including precuneus/posterior cingulate cortex (PCC), right and left dorsolateral prefrontal cortex (DLPFC) which accounted for 23.6% of the total subject voxel variance of the data and had 82.6% sensitivity and 79.1% specificity in discriminating AD from healthy controls. There was a significant relationship between the intensity of the 18F-THK5351 covariation pattern and cognitive scores in AD. The spatial patterns of 18F-THK5351 uptake showed significant similarity with intrinsic functional connectivity, especially in the PCC network. Seed-based connectivity analysis from the PCC showed significant decrease in connectivity over widespread brain regions in AD patients. An evaluation of an autopsied AD patient with Braak V showed that 18F-THK5351 retention corresponded to tau deposition, monoamine oxidase-B (MAO-B) and astrogliosis in the precuneus/PCC. Interpretation: We identified an AD-specific spatial pattern of 18F-THK5351 retention in the precuneus/PCC, an important connectivity hub region in the brain. Disruption of the functional connections of this important network hub may play an important role in developing dementia in AD.

DOI： 10.3389/fnagi.2018.00304

Open Access

Web of Science

PubMed

Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. Reviewed International coauthorship International journal Open Access

Toshiaki Taoka, Gregor Jost, Thomas Frenzel, Shinji Naganawa, Hubertus Pietsch

Investigative radiology Vol. 53 ( 9 ) page： 529 - 534 2018.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: The glymphatic system is a recently hypothesized waste clearance system of the brain in which perivascular space constitutes a pathway similar to the lymphatic system in other body regions. Sleep and anesthesia are reported to influence the activity of the glymphatic system. Because rats are nocturnal animals, the glymphatic system is expected to be more active during the day. We attempted to elucidate the influence of the glymphatic system for intravenously injected gadodiamide in the rat brain by 2 experiments. One was a magnetic resonance imaging (MRI) experiment to evaluate the short-term dynamics of signal intensity changes after gadodiamide administration. The other was a quantification experiment to evaluate the concentration of retained gadolinium within the rat brain after repeated intravenous administration of gadodiamide at different times of day and levels of anesthesia. MATERIALS AND METHODS: The imaging experiment was performed on 6 rats that received an intravenous injection of gadodiamide (1 mmol/kg) and dynamic MRI for 3 hours at 2.4-minute intervals. The time course of the signal intensity changes was evaluated for different brain structures. The tissue quantification experiment was performed on 24 rats divided into 4 groups by injection time (morning, late afternoon) and anesthesia (none, short, long) during administration. All animals received gadodiamide (1.8 mmol/kg, 8 times over 2 weeks). Gadolinium concentration of dissected brain tissues was quantified 5 weeks after the last administration by inductively coupled plasma mass spectrometry. RESULTS: In the imaging experiment, muscle and the fourth ventricle showed an instantaneous signal intensity increase immediately after gadodiamide injection. The signal curve of the cerebral cortex and deep cerebellar nuclei reached the peak signal intensity later than the fourth ventricle but earlier than that of the prepontine cistern. In the gadolinium quantification experiment, the concentration in the group with the morning injection showed a significantly lower concentration than the late afternoon injection group. The lowest tissue gadolinium concentrations were found in the groups injected in the morning during long anesthesia. CONCLUSIONS: Instantaneous transition of gadodiamide from blood to cerebrospinal fluid was indicated by dynamic MRI. The gadodiamide distribution to the cerebral cortex and deep cerebellar nuclei seemed to depend on both blood flow and cerebrospinal fluid. This confirms previous studies indicating that the cerebrospinal fluid is one potential pathway of gadolinium-based contrast agent entry into the brain. For the distribution and clearance of the gadodiamide from brain tissue, involvement of the glymphatic system seemed to be indicated in terms of the influence of sleep and anesthesia.

DOI： 10.1097/RLI.0000000000000473

Open Access

Web of Science

PubMed

Generative Adversarial Networkを用いた肺結節の画像生成について

伊藤倫太郎, 岩野信吾, 長縄慎二

日本医学放射線学会秋季臨床大会抄録集 Vol. 54回 page： S561 - S561 2018.9

Histogram analysis of quantitative pharmacokinetic parameters on DCE-MRI: correlations with prognostic factors and molecular subtypes in breast cancer.

Nagasaka K, Satake H, Ishigaki S, Kawai H, Naganawa S

Breast cancer (Tokyo, Japan) 2018.8

【膵癌update】　診断　MRI/MRCP

小川　浩、竹原康雄、長縄慎二

臨床消化器内科 Vol. 33 ( 7 ) page： 789-793 2018.7

Myocardial motion analysis based on an optical flow method using tagged MR images. Reviewed

Daiki Tabata, Haruo Isoda, Kaori Kato, Hiroki Matsubara, Takafumi Kosugi, Takashi Kosugi, Masaki Terada, Atsushi Fukuyama, Yoshiaki Komori, Shinji Naganawa

Radiological physics and technology Vol. 11 ( 2 ) page： 202 - 211 2018.6

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

We developed a method of velocimetry based on an optical flow method using quantitative analyses of tagged magnetic resonance (MR) images (tagged MR-optical flow velocimetry, tMR-O velocimetry). The purpose of our study was to examine the accuracy of measurement of the proposed tMR-O velocimetry. We performed retrospective pseudo-electrocardiogram (ECG) gating tagged cine MR imaging on a rotating phantom. We optimized imaging parameters for tagged MR imaging, and validated the accuracy of tMR-O velocimetry. Our results indicated that the difference between the reference velocities and the computed velocities measured using optimal imaging parameters was less than 1%. In addition, we performed tMR-O velocimetry and echocardiography on 10 healthy volunteers, for four sections of the heart (apical, midventricular, and basal sections aligned with the short-axis, and a four-chamber section aligned with the long-axis), and obtained radial and longitudinal myocardial velocities in these sections. We compared the myocardial velocities obtained using tMR-O velocimetry with those obtained using echocardiography. Our results showed good agreement between tMR-O velocimetry and echocardiography in the radial myocardial velocities in three short-axial sections and longitudinal myocardial velocities on the midventricular portion of the four-chamber section in the long-axis. In the study conducted on the rotating phantom, tMR-O velocimetry showed high accuracy; moreover, in the healthy volunteers, the myocardial velocities obtained using tMR-O velocimetry were relatively similar to those obtained using echocardiography. In conclusion, tMR-O velocimetry is a potentially feasible method for analyzing myocardial motion in the human heart.

DOI： 10.1007/s12194-018-0456-3

Web of Science

PubMed

Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging. Open Access

Yamada M, Taoka T, Kawaguchi A, Yasuda K, Niinomi Y, Ohashi Y, Okuda T, Naganawa S

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.5

Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Reviewed International journal

Suguru Yamada, Tsutomu Fujii, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Kojiro Suzuki, Tohru Okada, Eizaburo Ono, Junpei Yamaguchi, Nao Takano, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Yasuhiro Kodera

Cancer chemotherapy and pharmacology Vol. 81 ( 5 ) page： 815 - 821 2018.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: For unresectable locally advanced (UR-LA) pancreatic cancer, chemoradiotherapy has been recommended by the NCCN guidelines. We designed a chemoradiotherapy protocol using nab-paclitaxel combined with gemcitabine (GnP) for patients with UR-LA pancreatic cancer. The purpose of this phase I study was to determine a recommended dose (RD) for this novel regimen. METHODS: Patients with UR-LA pancreatic cancer were eligible. The frequency of dose-limiting toxicities (DLTs) was evaluated, and the RD was determined. Patients were classified according to the designated dose levels of chemoradiotherapy using the GnP regimen. After additional 6 cycles of the GnP regimen were administered, surgery was considered if the patients had stable disease and tumor marker levels had normalized. RESULTS: DLT (grade 4 thrombocytopenia) was observed only in 1 of 12 patients, and the RD was set at level 3. Grade 3-4 leukopenia was observed in 9 (75.0%) patients, and neutropenia in 7 (58.3%). The response rate was 41.7%, and the disease control rate was 100%. Conversion surgery was performed in 6 (50%) patients, and curative resection (R0) was performed in all 6 patients (100%). Stratification according to the Evans classification system demonstrated one patient with grade 1b, one with grade 2, two with grade 3, and two with grade 4 disease. CONCLUSION: The RD for weekly administration was 800 mg/m2 for gemcitabine and 100 mg/m2 for nab-paclitaxel with a 50.4 Gy radiation. The GnP regimen at this dosage was promising with 6 of 12 patients proceeding to conversion surgery, and should be evaluated further in a phase II trial.

DOI： 10.1007/s00280-018-3554-3

Web of Science

PubMed

Diagnostic performance of <sup>18</sup>F-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma. Open Access

Ishiguchi H, Ito S, Kato K, Sakurai Y, Kawai H, Fujita N, Abe S, Narita A, Nishio N, Muramatsu H, Takahashi Y, Naganawa S

Annals of nuclear medicine 2018.4

An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.

Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G

NeuroImage Vol. 169 page： 134 - 144 2018.4

Tau Kinetics in Neurons and the Human Central Nervous System Open Access

Sato Chihiro, Barthelemy Nicolas R., Mawuenyega Kwasi G., Patterson Bruce W., Gordon Brian A., Jockel-Balsarotti Jennifer, Sullivan Melissa, Crisp Matthew J., Kasten Tom, Kirmess Kristopher M., Kanaan Nicholas M., Yarasheski Kevin E., Baker-Nigh Alaina, Benzinger Tammie L. S., Miller Timothy M., Karch Celeste M., Bateman Randall J.

NEURON Vol. 97 ( 6 ) page： 1284 - + 2018.3

Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis.

Kamiya S, Iwano S, Umakoshi H, Ito R, Shimamoto H, Nakamura S, Naganawa S

Radiology page： 172319 2018.3

Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Open Access

Naganawa S, Kawai H, Taoka T, Sone M

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2018.3

Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

Journal of neurology Vol. 265 ( 3 ) page： 688-700 2018.3

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Papers - NAGANAWA, Shinji