Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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*Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate. Reviewed

Sato C, Naganawa S, Nakamura T, Kumada H, Miura S, Takizawa O, Ishigaki T

J Magn Reson Imaging Vol. 21 ( 3 ) page： 258-262 2005.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To compare the apparent diffusion coefficient (ADC) values of prostate cancer in both the peripheral zone (PZ) and the transition zone (TZ) with those of benign tissue in the same zone using echo-planar diffusion weighted imaging with a parallel imaging technique. MATERIALS AND METHODS: A total of 29 consecutive male patients (mean age 61.3 years, age range 53-88 years) with suspected prostate cancer were referred for MR imaging. All patients underwent transrectal ultrasound (TRUS)-guided biopsy of the prostate after MR imaging at 1.5 T, including ADC. For each patient, seven to 10 specimens were obtained from the prostate, and regions of interest (ROIs) were drawn on the ADC map by referring to the urologist's illustration of TRUS-guided biopsy sites. ADC values of cancerous tissue in both the PZ and TZ were compared to those of noncancerous tissue in the same zone. RESULTS: Out of 29 patients, 23 had cancer tissue. In the 23 patients with cancer, the mean ADC value of all cancer ROIs and that of all noncancer ROIs, respectively, were 1.11 +/- 0.41 x 10(-3) and 1.68 +/- 0.40 x 10(-3) mm(2)/second (values are mean +/- SD) (P < 0.01). The mean ADC value of TZ cancer ROIs and that of TZ noncancer ROIs, respectively, were 1.13 +/- 0.42 x 10(-3) and 1.58 +/- 0.37 x 10(-3) mm(2)/second (P < 0.01). CONCLUSIONS: ADC measurement with a parallel imaging technique showed that ADC values of prostate cancer in both the PZ and TZ were significantly lower than those of benign tissue in the PZ and TZ, respectively.

Diffusion-weighted imaging of the liver: technical challenges and prospects for the future. Reviewed

Naganawa S, Kawai H, Fukatsu H, Sakurai Y, Aoki I, Miura S, Mimura T, Kanazawa H, Ishigaki T

Magn Reson Med Sci Vol. 4 ( 4 ) page： 175 - 186 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Diffusion-weighted imaging (DWI) has recently been attempted in the abdominal region. We review diffusion-weighted images of the liver, especially from the technical point of view. We discuss selection of pulse sequence parameters, effects of anti-breathing motion technique, tips for measuring apparent diffusion coefficient (ADC), and utility of superparamagnetic iron oxide (SPIO), showing clinical cases, including those at 3T. Our current trial of new pulse sequencing, such as SPIO-mediated breath-holding black-blood fluid-attenuated inversion recovery (BH-BB-FLAIR), imaging is shown. Some prospects for the future in DWI of the liver are also stated.

Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. Reviewed

Naganawa S, Sato C, Kumada H, Ishigaki T, Miura S, Takizawa O

Eur Radiol Vol. 15 ( 1 ) page： 71-78 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09+/-0.20 x 10(-3) mm2/s, and that of normal cervix tissue was 1.79+/-0.24 x 10(-3) mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.

Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes. Reviewed

Sugiura M, Sato E, Nakashima T, Sugiura J, Furuhashi A, Yoshino T, Nakayama A, Mori N, Murakami H, Naganawa S

Eur Arch Otorhinolaryngol Vol. 262 ( 9 ) page： 737-743 2005

Language：English Publishing type：Research paper (scientific journal)

Fourteen patients with a Pendred syndrome gene (Pds) mutation and three patients without the mutation were studied to evaluate long-term vestibular and auditory manifestations among patients with bilateral enlarged vestibular aqueducts (EVA). Charts were reviewed retrospectively for age, gender, otological history, presence or absence of vertigo, results of magnetic resonance imaging, relevant gene mutations and perchlorate discharge test. A missense mutation, His 723 Arg (H723R), was identified in the homozygous state in six patients and in the heterozygous state in seven patients. Another missense mutation, Tyr 410 Met (T410 M), was identified in the heterozygous state in one patient. Patients with vertigo tended to have hearing fluctuation, compared with the patients without vertigo. Patients homozygous for H723R tended to have more episodes of vertigo than the heterozygous individuals. Only one patient who was homozygous for H723R had goiter. The long-term outcome of hearing level in patients with the H723R mutation was significantly better compared with published results for patients with a Pds mutation, but not for those with the H723R mutation. Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified.

Contralateral and ipsilateral responses in primary somatosensory cortex following electrical median nerve stimulation--an fMRI study. Reviewed

Nihashi T, Naganawa S, Sato C, Kawai H, Nakamura T, Fukatsu H, Ishigaki T, Aoki I

Clin Neurophysiol Vol. 116 ( 4 ) page： 842-848 2005

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Ten healthy adult subjects were examined using functional magnetic resonance imaging (fMRI) to investigate responses in the contralateral and ipsilateral primary somatosensory cortex (SI) following electrical stimulation of the median nerve. METHODS: The right and left median nerves were stimulated alternately at the wrist in the different sessions. First, the location of the response in contralateral SI was identified following median nerve stimulation, and then, a spherical search volume with a 10mm radius centered on the region of the contralateral response was determined. Whether or not fMRI activation occurred within this sphere following ipsilateral stimulation was examined using a 3T MR imager. RESULTS: A response in contralateral SI was observed in 8 of the 10 subjects in right and left hemisphere. Responses in ipsilateral SI were observed in 6 of 8 subjects in right hemisphere, and the region of the response tended to be posterior to the contralateral region. On the other hand, in left hemisphere, the ipsilateral responses were found in three. CONCLUSIONS: In the present study, not only contralateral SI but also ipsilateral SI was activated following median nerve. The location of the ipsilateral activation was significantly more posterior than the contralateral one in right hemisphere. SIGNIFICANCE: The region of activation in ipsilateral SI was located in the posterior portion of post central gyrus, corresponding to around BA2 and 5 in human.

Sudden sensorineural hearing loss associated with inner ear anomaly. Reviewed

Sugiura M, Nakashima T, Naganawa S, Otake Y, Mukaida T, Sone M, Sato E

Otol Neurotol Vol. 26 ( 2 ) page： 241-246 2005

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This study was conducted to evaluate the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss and in control subjects. STUDY DESIGN: Retrospective case review. SETTING: A tertiary referral center. PATIENTS AND INTERVENTION: We evaluated 366 patients (165 men and 201 women; age range, 3-91 yr) with sudden sensorineural hearing loss and 228 control subjects without sensorineural hearing loss using magnetic resonance imaging. Three hundred fifty-six patients had unilateral and 10 patients had bilateral sudden sensorineural hearing loss. RESULTS: Eleven (2.9%) of 376 ears with sudden sensorineural hearing loss had inner ear anomaly. Nine patients (2.5%) had inner ear anomaly associated with sudden sensorineural hearing loss, but none of the 228 control subjects had the anomaly. The current study demonstrated that the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss was significantly higher than in control subjects. CONCLUSION: Our study reveals that inner ear anomaly may be associated with sudden sensorineural hearing loss in 2.5% of patients.

Diffusion-weighted images of the liver: comparison of tumor detection before and after contrast enhancement with superparamagnetic iron oxide.

Naganawa S, Sato C, Nakamura T, Kumada H, Ishigaki T, Miura S, Maruyama K, Takizawa O

J Magn Reson Imaging Vol. 21 ( 6 ) page： 836-840 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To study the recognition of malignant lesions of the liver on diffusion-weighted images (DWI) can be improved by the administration of superparamagnetic iron oxide (SPIO). MATERIALS AND METHODS: Pre- and post-SPIO mediated DWI of the liver was compared in six patients with suspected malignant liver lesions at 1.5 Tesla using a parallel imaging technique. RESULTS: Post-SPIO DWI showed improved contrast-to-noise ratio between malignant lesions and liver. Furthermore, the spleen signal was decreased on post-SPIO DWI, thus avoiding the overlap of the spleen and left lobe of the liver on maximum intensity projections (MIP). CONCLUSION: Recognition of malignant lesions of the liver was improved by SPIO on DWI. On MIP images of DWI, SPIO helped to decrease the overlap of spleen signal on the liver in some projection angles.

Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test. Reviewed

Mimura T, Sato E, Sugiura M, Yoshino T, Naganawa S, Nakashima T

Int J Audiol Vol. 44 ( 8 ) page： 466-469 2005

Language：English Publishing type：Research paper (scientific journal)

The Bing test is based on the principle that occlusion of the external auditory meatus improves the perception of bone-conducted sounds unless there is a conductive hearing impairment. An air-bone gap has been reported in patients with large vestibular aqueduct (LVA) syndrome without apparent middle ear dysfunction. We therefore performed the Bing test on nine patients with this syndrome to evaluate whether it is associated with an air-bone gap or middle ear dysfunction. Bone conduction thresholds did not change significantly during the Bing test in any patient. Because an air-bone gap is observed in patients with abnormal communication between the inner ear and cerebrospinal fluid through the LVA, dehiscent superior canal, or dilated inner ear meatus; we propose that a 'three windows' model (in which the abnormal communication provided by the enlarged endolymphatic duct and sac in LVA acts as the 'third window' for sound conductance) might explain the air-bone gap in such patients.

【最近の画像診断の進歩　CT,MRI,PET】　高磁場MRI

長縄慎二

日本医師会雑誌 Vol. 134 page： 1722-1726 2005

多系統萎縮症における認知機能障害　画像との関連

川合圭成, 伊藤瑞規, 渡邉宏久, 祖父江元, 武田章敬, 長縄慎二, 深津博, 加藤克彦, 石垣武男

臨床神経学 Vol. 45 page： 1185 2005

第３３回日本磁気共鳴医学会大会にみるBody diffusionの動向

長縄慎二

Innervision Vol. 20 ( 12 ) page： 112 2005

高磁場MRI

長縄慎二

日本医師会雑誌 Vol. 134 ( 9 ) page： 1722-1726 2005

超高磁場MRIのインパクト(3T MRIをふくめて）脳以外への活用方法

長縄慎二

日独医報 Vol. 50 ( 3 ) page： 479-489 2005

前立腺癌，子宮頸癌におけるADC測定の意義

長縄慎二

画像診断 Vol. 25 ( 6 ) page： 737-743 2005

Authorship：Lead author Language：Japanese

DWIBSにおいての癌描出のメカニズムは十分に把握されておらず，基礎的な検討としても，現時点での臨床的な課題としても，さまざまな種類の癌のADCを測定することが重要である．前立腺癌と子宮頸癌におけるADC計測の結果と臨床的な位置付けを1.5T，3Tでの結果に基づいて解説する

電子ポスター(Cypos)元年　JRC2005を振り返って

石垣武男　藤田広志　深津博　長縄慎二　片渕哲朗　原武史

Innervision Vol. 20 ( 7 ) page： 28-33 2005

第64回日本医学放射線学会学術集会　イメージインタープリテーションセッション症例出題集

長縄慎二、原真咲

日本医学放射線学会誌別冊付録 Vol. 65 ( 3 ) page： 1-28 2005

第64回日本医学放射線学会学術集会　イメージインタープリテーションセッション症例出題集

長縄慎二、原真咲

日本医学放射線学会誌別冊付録 Vol. 65 ( 2 ) page： 1-14 2005

【医療環境の変化に対して放射線診療は今後どう対応すべきか　画像診断を中心に】　高度画像診断機器導入による画像診断へのインパクト　医療制度の変化を踏まえて　超高磁場MRIのインパクト(3T MRIを含めて)　脳以外への活用方法

長縄慎二

日独医報 Vol. 50 page： 479-489 2005

多発性硬化症におけるIsotropic 3D FLAIR法の有用性

末永正機, 伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 深津博, 長縄慎二

臨床神経学 Vol. 45 page： 1035 2005

多系統萎縮症とパーキンソン病の鑑別　橋の拡散テンソル画像,拡散強調画像の有用性

伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

臨床神経学 Vol. 45 page： 1168 2005

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Papers - NAGANAWA, Shinji