Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients.

Nihashi, Takashi; Yatsuya, Hiroshi; Hayasaka, Kazumasa; Kato, Rikio; Kawatsu, Shoji; Arahata, Yutaka; Iwai, Katsushige; Takeda, Akinori; Washimi, Yukihiko; Yoshimura, Kumiko; Mizuno, Kanako; Kato, Takashi; Naganawa, Shinji; Ito, Kengo

Radiat Med Vol. 25 page： 225-262 2007

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). MATERIALS AND METHODS: FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. CONCLUSION: No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

【3T MRIの最新情報】頭部MRIの最新情報

長縄慎二

Vol. 10 page： 7-11 2007

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

信号雑音比的に厳しい3D-FLAIRや拡散テンソルといった特殊なコントラストを要求すると、1.5T装置では信号雑音比の不足に悩まされる。そういった厳しい領域に挑戦していくことが、確実に3T装置の有用性を表現する方法である。3D-SPACEによるFLAIR,STIR,T1強調について述べ、最近、有用性の報告の多いsusceptibility weighted image(SWI)を紹介する。(著者抄録)

側頭骨内耳・内耳道

長縄慎二

日本医学放射線学会雑誌 page： 87 2007

肺癌の類似CT画像検索CADの初期的検討

岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

日本医学放射線学会雑誌 page： 182-183 2007

3T MRIによる磁化率強調画像(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

久保田誠司, 川井恒, 深津博, 長縄慎二

日本医学放射線学会雑誌 page： 188-189 2007

遠隔画像診断クリニックにおける業務分析と課題

村瀬詠子, 深津恵理子, 石垣武男, 古賀佑彦, 加藤克彦, 深津博, 長縄慎二, 島本佳寿広

日本医学放射線学会雑誌 page： 204-205 2007

腹腔動脈狭窄に因る膵仮性動脈瘤に対するTAE

鈴木耕次郎, 館靖, 森芳峰, 太田豊裕, 長縄慎二, 丸山邦弘, 伊藤信嗣, 白石里支

日本医学放射線学会雑誌 page： 269 2007

Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

小川浩, 伊藤茂樹, 鈴木耕次郎, 長縄慎二

日本医学放射線学会雑誌 page： 349 2007

腹側膵領域の限局性炎症の画像所見

伊藤茂樹, 鈴木耕次郎, 川井恒, 長縄慎二

日本医学放射線学会雑誌 page： 350 2007

鼓室内Gd注入による迷路内リンパ水腫の観察

長縄慎二, 深津博, 川井恒

日本医学放射線学会雑誌 page： 360 2007

人工知能Neural Networkを用いたLossless画像圧縮方法(JIS圧縮法)の開発と評価

深津博, 長縄慎二, 湯村眞一郎

日本医学放射線学会雑誌 page： 383-384 2007

ネットワーク上の情報のorganic recirculation　比較CT interpretationにおける放射線科医に及ぼすその臨床的影響(Organic Recirculation of Information On Network: Its Clinical Impact for Radiologists in Comparative CT Interpretation)

深津博, 長縄慎二, 長田雅和, 増沢高

日本医学放射線学会雑誌 page： 384-385 2007

拡散テンソル画像を用いた多系統萎縮症とパーキンソン病の錐体路評価

伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

臨床神経学 Vol. 46 page： 1084 2007

Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis. Reviewed

Hirasawa, Naoki; Tsuji, Hiroshi; Ishikawa, Hitoshi; Koyama-Ito, Hiroko; Kamada, Tadashi; Mizoe, Jun-Etsu; Ito, Yoshiyuki; Naganawa, Shinji; Ohnishi, Yoshitaka; Tsujii, Hirohiko

Int J Radiat Oncol Biol Phys Vol. 67 page： 538-543 2007

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine the risk factors for neovascular glaucoma (NVG) after carbon ion radiotherapy (C-ion RT) of choroidal melanoma. METHODS AND MATERIALS: A total of 55 patients with choroidal melanoma were treated between 2001 and 2005 with C-ion RT based on computed tomography treatment planning. All patients had a tumor of large size or one located close to the optic disk. Univariate and multivariate analyses were performed to identify the risk factors of NVG for the following parameters; gender, age, dose-volumes of the iris-ciliary body and the wall of eyeball, and irradiation of the optic disk (ODI). RESULTS: Neovascular glaucoma occurred in 23 patients and the 3-year cumulative NVG rate was 42.6 +/- 6.8% (standard error), but enucleation from NVG was performed in only three eyes. Multivariate analysis revealed that the significant risk factors for NVG were V50IC (volume irradiated > or =50 GyE to iris-ciliary body) (p = 0.002) and ODI (p = 0.036). The 3-year NVG rate for patients with V50IC > or =0.127 mL and those with V50IC <0.127 mL were 71.4 +/- 8.5% and 11.5 +/- 6.3%, respectively. The corresponding rate for the patients with and without ODI were 62.9 +/- 10.4% and 28.4 +/- 8.0%, respectively. CONCLUSION: Dose-volume histogram analysis with computed tomography indicated that V50IC and ODI were independent risk factors for NVG. An irradiation system that can reduce the dose to both the anterior segment and the optic disk might be worth adopting to investigate whether or not incidence of NVG can be decreased with it.

Contrast enhanced MR imaging of the brain using T1-FLAIR with BLADE compared with conventional spin echo sequence

S.Naganawa,H.Kawai,and H.Fukatsu

Proc.Intl.Soc.Mag.Reson.Med Vol. 15 page： 2110 2007

Parry-Romberg syndrome with a clinically silent white matter lesion. Reviewed

Okumura A, Ikuta T, Tsuji T, Kato T, Fukatsu H, Naganawa S, Kato K, Watanabe K

AJNR Am J Neuroradiol Vol. 27 ( 8 ) page： 1729-1731 2006.9

Language：English Publishing type：Research paper (scientific journal)

We performed a detailed neuroimaging study in a patient with Parry-Romberg syndrome. Proton MR spectroscopy demonstrated normal spectral patterns, though conventional MR imaging revealed high-intensity areas in the entire white matter in the left hemisphere. Single-photon emission tomography showed increased perfusion in the cortex of the affected hemisphere. Pyramidal tracts and optic radiations were preserved on diffusion tensor tractography. We will correlate these neuroimaging findings with normal psychomotor development in our patient.

Prompt contrast enhancement of cerebrospinal fluid space in the fundus of the internal auditory canal: observations in patients with meningeal diseases on 3D-FLAIR images at 3 Tesla. Reviewed

Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Nakashima T, Maruyama K

Magn Reson Med Sci Vol. 5 ( 3 ) page： 151-155 2006

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

We speculated that meningeal pathologies might facilitate the permeability of cranial nerves at the fundus of the internal auditory canal (IAC), causing prompt enhancement after administration of Gd-DTPA. Using a 3D- fluid-attenuated inversion recovery (FLAIR) sequence, we evaluated the enhancement of the cerebrospinal fluid (CSF) space in the IAC fundus 10 min after Gd-DTPA administration in patients with meningeal diseases. Twenty patients (aged 22 to 79 years) were divided into 2 groups, a group with meningeal disease comprising 9 patients with meningeal abnormalities (6, tumor dissemination; 3, infection) and a control group of 11 patients with unilateral IAC pathology whose healthy sides were included as controls. Six of the 9 patients in the group with meningeal disease showed bilateral enhancement; one showed unilateral enhancement. None of the control group showed enhancement in the healthy side. One patient with Ramsay-Hunt syndrome showed only ipsilateral enhancement. Enhancement in the IAC fundus was frequently observed in patients with meningeal disease, even just 10 min after administration of contrast agent. This enhancement in the IAC fundus was never visible on T1-weighted 3D-FLASH images.

*Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla. Reviewed

Naganawa S, Komada T, Fukatsu H, Ishigaki T, Takizawa O

Eur Radiol Vol. 16 ( 3 ) page： 733-737 2006

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

In animals, the enhancement of perilymph in the cochlea has been reported using 1.25 mmol/kg of Gd-DTPA, allowing the separate visualisation of perilymph and endolymph for the diagnosis of Meniere's disease. The purpose of this study was three-fold: (1) to determine the optimal timing for detecting cochlear fluid enhancement using 3D-FLAIR (fluid-attenuated inversion recovery) after intravenous administration of 0.1 mmol/kg of Gd-DTPA in healthy human subjects; (2) to examine the reliability of enhancement in multiple healthy subjects; and (3) to investigate whether endolymph and perilymph space can be visually discriminated. In two healthy subjects, 3D-FLAIR images were obtained before, immediately after and 2 h, 4 h and 6 h after the injection. Three more healthy subjects were scanned before and 4 h after the injection. In all four ears of the initial two subjects, cochlear fluid was found to be most intensely enhanced 4 h after the injection. In all of the additional three subjects, the cochlear fluid signal had increased after 4 h from injection. However, visual differentiation of endolymph and perilymph fluid could not be achieved. Using 3D-FLAIR and Gd-DTPA, cochlear fluid enhancement can be observed in healthy human ears, even with a single dose of contrast-medium injection.

Relationship between CT densitometry with a slice thickness of 0.5 mm and audiometry in otosclerosis. Reviewed

Kawase S, Naganawa S, Sone M, Ikeda M, Ishigaki T

Eur Radiol Vol. 16 ( 6 ) page： 1367-1373 2006

Language：English Publishing type：Research paper (scientific journal)

The appropriate cutoff Hounsfield unit (HU) value for the diagnosis of otosclerosis was determined and the correlation between the bone conduction threshold and the findings of computed tomography (CT) densitometry investigated. CT images, 0.5-mm thick, were evaluated in 24 ears with otosclerosis and 19 control ears. Eight regions of interest were set around the otic capsule. The mean HU values in the area anterior to the oval window (A-OW) and anterior to the internal auditory canal (A-IAC) were significantly lower in otosclerosis than in controls. Based on receiver operating characteristic (ROC) analysis, the cutoff HU value in A-OW was determined to be 2,187.3 HU. The mean HU value in retrofenestral otosclerosis was significantly lower in the area A-OW, A-IAC and around the cochlea than in controls. Based on ROC analysis, the cutoff HU value in the latter was determined to be 2,045 HU. A statistically significant correlation was found between the density of the area A-OW and the hearing level at 500 and 1,000 Hz, and between the density of the area around the cochlea and the hearing level at most frequencies. These results suggest the semi-automated diagnosis of otosclerosis may be possible.

Blood flow to the promontory in cochlear otosclerosis. Reviewed

Nakashima T, Sone M, Fujii H, Teranishi M, Yamamoto H, Otake H, Sugiura M, Naganawa S

Clin Otolaryngol Vol. 31 ( 2 ) page： 110-115 2006

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis. DESIGN: Prospective clinical study. SETTING: Tertiary referral centre. PARTICIPANTS: Five patients with cochlear otosclerosis and five control subjects. Significant decalcification around the cochlea was observed by computed tomography (CT) in patients with cochlear otosclerosis. However, no recognizable lesion was observed at the oval window in two patients. One patient had mixed hearing loss and four patients had sensorineural hearing loss without an air-bone gap. Main outcome measures: The relationship between CT findings and the presence or absence of Schwartze sign was investigated. Blood flow to the promontory was measured through the tympanic membrane using laser speckle flowgraphy and laser Doppler flowmetry. Results: The Schwartze sign correlated significantly with otosclerotic lesions invading the promontory. Patients with otosclerosis exhibited elevated and pulsating blood flow to the promontory with the Schwartze sign. CONCLUSIONS: Computed tomography demonstrated that cochlear otosclerosis can exist without the oval window lesion. Schwartze sign can be used as a sign of the otosclerotic invasion to the promontory. The reddening of the Schwartze sign is likely due to increased blood flow.

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Papers - NAGANAWA, Shinji