Faculty Profiles - NAGANAWA, Shinji

Papers - NAGANAWA, Shinji

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RVS（Real-time Virtual Sonography）技術の乳腺領域への応用

佐竹弘子、西尾明子、石垣聡子、福原理恵子、島本佳寿広、今井常夫、小田高司、菊森豊根、澤木正孝、長縄慎二

乳癌の臨床 Vol. 22 ( 5 ) page： 438(86)-439(87) 2007.10

Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastasesof thyroid cancer. Reviewed

Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S,Nishino M, Ishigaki T, Naganawa S.

J Nucl Med. Vol. 48 ( 6 ) page： 889-895 2007.6

Usefulness of FDG PET for diagnosis and radiotherapy of the patient with malignant lymphoma involving bone marrow. Reviewed

Nihashi, Takashi; Hayasaka, Kazumasa; Itou, Toshihide; Sobajima, Takashi; Kato, Rikio; Ito, Kengo; Ito, Yoshiyuki; Ishigaki, Takeo; Naganawa, Shinji

Radiat Med Vol. 25 ( 3 ) page： 130-4 2007.4

Language：English Publishing type：Research paper (scientific journal)

We experienced a case of relapsed malignant lymphoma with multiple bone marrow or bone lesions. The case was diagnosed as follicular lymphoma by cytological biopsy of the right iliac bone, with (67)Ga scintigraphy showing abnormal, intense uptake in multiple bones. After about 10 months of systemic chemotherapy, a relapse was suspected because of pain in the bilateral legs and a high level of lactate dehydrogenase. Assessment of the lesions in the patient was difficult by computed tomography because the affected sites were localized mainly in the bone marrow. (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) was useful for detecting accurately the relapse sites in the bone marrow and enabled us to determine the field for radiotherapy. There are only a few reports of FDG-PET findings for such bone marrow malignant lymphomas. Therefore, we report the findings of FDG-PET for this case and review some of the literature about bone marrow lymphomas.

Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. Reviewed

Ito, Mizuki; Watanabe, Hirohisa; Kawai, Yoshinari; Atsuta, Naoki; Tanaka, Fumiaki; Naganawa, Shinji; Fukatsu, Hiroshi; Sobue, Gen

J Neurol Neurosurg Psychiatry Vol. 78 page： 722-728 2007.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To determine whether apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values can detect early pathological involvement in multiple system atrophy (MSA), and be used to differentiate MSA-P (multiple system atrophy if parkinsonian features predominate) from Parkinson's disease (PD). METHODS: We compared ADC and FA values in the pons, cerebellum and putamen of 61 subjects (20 probable MSA patients, 21 age matched PD patients and 20 age matched healthy controls) using a 3.0 T magnetic resonance system. RESULTS: ADC values in the pons, cerebellum and putamen were significantly higher, and FA values lower in MSA than in PD or controls. These differences were prominent in MSA lacking dorsolateral putaminal hyperintensity (DPH) or hot cross bun (HCB) sign. In differentiating MSA-P from PD using FA and ADC values, we obtained equal sensitivity (70%) and higher specificity (100%) in the pons than in the putamen and cerebellum. In addition, all patients that had both significant low FA and high ADC values in each of these three areas were MSA-P cases, and those that had both normal FA and ADC values in the pons were all PD cases. Our diagnostic algorithm based on these results accurately diagnosed 90% of patients with MSA-P. CONCLUSION: FA and ADC values detected early pathological involvement prior to magnetic resonance signal changes in MSA. In particular, low FA values in the pons showed high specificity in discriminating MSA-P from PD. In addition, combined analysis of both FA and ADC values in all three areas was more useful than only one.

3D-FLAIR MRI findings in a patient with Ramsay Hunt syndrome. Reviewed

Sugiura M, Naganawa S, Nakata S, Kojima S, Nakashima T

Acta Otolaryngol Vol. 127 ( 5 ) page： 547-549 2007

Language：English Publishing type：Research paper (scientific journal)

Three-dimensional, fluid-attenuated inversion recovery (3D-FLAIR) of magnetic resonance imaging (MRI) has recently been developed to detect hemorrhage or high concentrations of protein. We present a patient with Ramsay Hunt syndrome, in whom high signals in the cochlear and vestibular apparatus were identified with 3D-FLAIR. The high signal areas in 3D-FLAIR were not detected by T1- and T2-weighted MRI in this case. This is the first report of high concentrations of protein in the inner ear in Ramsay Hunt syndrome using 3D-FLAIR, and suggests that high concentrations of protein in the inner ear are associated with hearing deterioration in some patients with Ramsay Hunt syndrome. 3D-FLAIR could be a useful diagnostic tool in the early stages of Ramsay Hunt syndrome.

*Visualization of endolymphatic hydrops in patients with Meniere's disease. Reviewed

Nakashima T, Naganawa S, Sugiura M, Teranishi M, Sone M, Hayashi H, Nakata S, Katayama N, Ishida IM

Laryngoscope Vol. 117 ( 3 ) page： 415-420 2007

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Recently, there have been many reports of intratympanic gentamicin therapy for the treatment of intractable Meniere's disease. Intratympanic administration of steroids has also been used to treat sudden sensorineural hearing loss. We attempted to visualize how the intratympanically administered drug enters the inner ear. METHODS: Gadolinium hydrate diluted eightfold with saline was injected intratympanically through the tympanic membrane using a 23 G needle in nine patients with inner ear diseases. With a 3 Tesla magnetic resonance imaging (MRI) unit, three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) imaging was performed. RESULTS: 3D-FLAIR MRI clearly revealed that the gadolinium entered the perilymphatic space and delineated the perilymphatic and endolymphatic spaces of the inner ear. In patients with endolymphatic hydrops, the perilymphatic space surrounding the endolymph was small or had disappeared. Gadolinium appeared first in the scala tympani of the basal turn of the cochlea and the perilymphatic space of the vestibule. One day after the intratympanic injection of gadolinium, the gadolinium was observed in almost all parts of the perilymph. Six days after the intratympanic injection, the gadolinium had almost disappeared from the inner ear. CONCLUSION: We reported the first visualization of endolymphatic hydrops in patients with Meniere's disease. The relationship between the image of the endolymphatic space and functional tests, such as electrocochleography and vestibular-evoked myogenic potential, must be examined in the near future. It is important for the development of intratympanic drug therapies for inner-ear diseases to investigate how the drugs enter and leave the inner ear.

【マルチモダリティによるHead & Neck Imaging 2007　臨床編　日常臨床における戦略と選択】側頭骨・耳(中耳・内耳・外耳)　難聴とめまいにおける画像診断の現状と進歩　名古屋大学医学部附属病院

長縄慎二

INNERVISION Vol. 22 page： 8-11 2007

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

難聴、めまいは病院を訪れる主訴として非常に多い。両者を合併することもある。これらの病態の診断で最も大切なのは、言うまでもなく十分な病歴聴取である。さらに聴力検査、注視眼振検査、頭位眼振検査、温度刺激試験、下位脳神経障害や中耳炎の有無を調べる耳鼻咽喉科的一般所見などの検査で引き続き診断を進め、血液検査や他の部位の画像検査で全身疾患の有無も調べる必要がある。局所つまり側頭骨の画像検査はそれらを補完する意義を持つ。側頭骨画像診断についてはCT,MRIが最も重要な画像検査であるが、本稿では側頭骨におけるCT,MRIの撮像法の原則を述べた後、病態ごとに画像診断のポイント、最近の進歩を述べ、最後に難聴における画像診断の進め方のデシジョンツリーをシェーマとしてまとめることとする。(著者抄録)

【3T MRIの最新情報】頭部MRIの最新情報

長縄慎二

Vol. 10 page： 7-11 2007

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

信号雑音比的に厳しい3D-FLAIRや拡散テンソルといった特殊なコントラストを要求すると、1.5T装置では信号雑音比の不足に悩まされる。そういった厳しい領域に挑戦していくことが、確実に3T装置の有用性を表現する方法である。3D-SPACEによるFLAIR,STIR,T1強調について述べ、最近、有用性の報告の多いsusceptibility weighted image(SWI)を紹介する。(著者抄録)

側頭骨内耳・内耳道

長縄慎二

日本医学放射線学会雑誌 page： 87 2007

肺癌の類似CT画像検索CADの初期的検討

岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

日本医学放射線学会雑誌 page： 182-183 2007

3T MRIによる磁化率強調画像(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

久保田誠司, 川井恒, 深津博, 長縄慎二

日本医学放射線学会雑誌 page： 188-189 2007

遠隔画像診断クリニックにおける業務分析と課題

村瀬詠子, 深津恵理子, 石垣武男, 古賀佑彦, 加藤克彦, 深津博, 長縄慎二, 島本佳寿広

日本医学放射線学会雑誌 page： 204-205 2007

腹腔動脈狭窄に因る膵仮性動脈瘤に対するTAE

鈴木耕次郎, 館靖, 森芳峰, 太田豊裕, 長縄慎二, 丸山邦弘, 伊藤信嗣, 白石里支

日本医学放射線学会雑誌 page： 269 2007

Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

小川浩, 伊藤茂樹, 鈴木耕次郎, 長縄慎二

日本医学放射線学会雑誌 page： 349 2007

腹側膵領域の限局性炎症の画像所見

伊藤茂樹, 鈴木耕次郎, 川井恒, 長縄慎二

日本医学放射線学会雑誌 page： 350 2007

鼓室内Gd注入による迷路内リンパ水腫の観察

長縄慎二, 深津博, 川井恒

日本医学放射線学会雑誌 page： 360 2007

人工知能Neural Networkを用いたLossless画像圧縮方法(JIS圧縮法)の開発と評価

深津博, 長縄慎二, 湯村眞一郎

日本医学放射線学会雑誌 page： 383-384 2007

ネットワーク上の情報のorganic recirculation　比較CT interpretationにおける放射線科医に及ぼすその臨床的影響(Organic Recirculation of Information On Network: Its Clinical Impact for Radiologists in Comparative CT Interpretation)

深津博, 長縄慎二, 長田雅和, 増沢高

日本医学放射線学会雑誌 page： 384-385 2007

Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients.

Nihashi, Takashi; Yatsuya, Hiroshi; Hayasaka, Kazumasa; Kato, Rikio; Kawatsu, Shoji; Arahata, Yutaka; Iwai, Katsushige; Takeda, Akinori; Washimi, Yukihiko; Yoshimura, Kumiko; Mizuno, Kanako; Kato, Takashi; Naganawa, Shinji; Ito, Kengo

Radiat Med Vol. 25 page： 225-262 2007

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). MATERIALS AND METHODS: FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. CONCLUSION: No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis. Reviewed

Hirasawa, Naoki; Tsuji, Hiroshi; Ishikawa, Hitoshi; Koyama-Ito, Hiroko; Kamada, Tadashi; Mizoe, Jun-Etsu; Ito, Yoshiyuki; Naganawa, Shinji; Ohnishi, Yoshitaka; Tsujii, Hirohiko

Int J Radiat Oncol Biol Phys Vol. 67 page： 538-543 2007

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine the risk factors for neovascular glaucoma (NVG) after carbon ion radiotherapy (C-ion RT) of choroidal melanoma. METHODS AND MATERIALS: A total of 55 patients with choroidal melanoma were treated between 2001 and 2005 with C-ion RT based on computed tomography treatment planning. All patients had a tumor of large size or one located close to the optic disk. Univariate and multivariate analyses were performed to identify the risk factors of NVG for the following parameters; gender, age, dose-volumes of the iris-ciliary body and the wall of eyeball, and irradiation of the optic disk (ODI). RESULTS: Neovascular glaucoma occurred in 23 patients and the 3-year cumulative NVG rate was 42.6 +/- 6.8% (standard error), but enucleation from NVG was performed in only three eyes. Multivariate analysis revealed that the significant risk factors for NVG were V50IC (volume irradiated > or =50 GyE to iris-ciliary body) (p = 0.002) and ODI (p = 0.036). The 3-year NVG rate for patients with V50IC > or =0.127 mL and those with V50IC <0.127 mL were 71.4 +/- 8.5% and 11.5 +/- 6.3%, respectively. The corresponding rate for the patients with and without ODI were 62.9 +/- 10.4% and 28.4 +/- 8.0%, respectively. CONCLUSION: Dose-volume histogram analysis with computed tomography indicated that V50IC and ODI were independent risk factors for NVG. An irradiation system that can reduce the dose to both the anterior segment and the optic disk might be worth adopting to investigate whether or not incidence of NVG can be decreased with it.

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Papers - NAGANAWA, Shinji