Faculty Profiles - YATSUYA Hiroshi

降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

内藤久雄, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

産業衛生学雑誌 Vol. 62 ( 臨増 ) page： 610 - 610 2020.5

内藤久雄, 袁媛, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

日本衛生学雑誌 Vol. 75 ( Suppl. ) page： S161 - S161 2020.3

トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 柳場由絵, 八谷寛, 上島通浩

産業衛生学雑誌 Vol. 62 ( 2 ) page： 105 - 105 2020.3

労働者の生活習慣指導のありかた特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合愛知職域コホート研究

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 Vol. 62 ( 2 ) page： 94 - 94 2020.3

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Tetsushi Yoshikawa

Transplant infectious disease : an official journal of the Transplantation Society Vol. 22 ( 1 ) page： e13203 2020.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. METHODS: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. RESULTS: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P < .0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P = .0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P = .0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P = .0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. CONCLUSION: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

DOI： 10.1111/tid.13203

Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease. Reviewed

Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Junpei Yamamoto, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

Journal of epidemiology Vol. 30 ( 1 ) page： 37 - 45 2020.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. METHODS: The study design was a prospective cohort study. During 1995-1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45-74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. RESULTS: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93-1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. CONCLUSIONS: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.

DOI： 10.2188/jea.JE20180130

Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

Journal of atherosclerosis and thrombosis Vol. 27 ( 4 ) page： 363 - 374 2020

Language：English Publishing type：Research paper (scientific journal)

AIM: A positive association between non-high-density lipoprotein cholesterol (non-HDL-C) and coronary heart disease (CHD) has been established; however, associations between non-HDL-C and stroke subtypes have not been determined. METHODS: We conducted a prospective study of 30,554 individuals aged 40-69 yrs with no history of cardiovascular disease (CVD) in Japan. Sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of stroke subtypes and CHD were estimated according to quintiles of non-HDL-C, using Cox proportional hazard models adjusted for other established risk factors. RESULTS: We identified 1,705 stroke and 296 CHD events over a median 15 yrs of follow-up. The fractional polynomials analysis revealed a U-shaped association between non-HDL-C and stroke risk in men. When analyzed for stroke subtypes, the data revealed an inverse relationship between non-HDL-C and intracerebral hemorrhage (ICH), primarily with lobar ICH, and a positive association between non-HDL-C and large-artery occlusive infarction in men [adjusted HR 0.55 (95% CI, 0.35-0.87) and 2.05 (95% CI, 1.07-3.93) for the highest and lowest quintile of non-HDL-C, respectively]. The lowest risk of ICH in women was observed in the fourth quintile, and the lowest risk of embolic infarction was observed in the third quintile. In contrast, non-HDL-C was positively associated with CHD in both sexes. CONCLUSIONS: In Japanese men, lower non-HDL-C levels were associated with a decreased risk of large-artery occlusive infarction and an increased risk of ICH, particularly lobar ICH.

DOI： 10.5551/jat.50385

Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study. Reviewed

Naohito Tanabe, Nao Seki, Chika Horikawa, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Shigekazu Ukawa, Akiko Tamakoshi

Internal medicine (Tokyo, Japan) Vol. 59 ( 24 ) page： 3123 - 3130 2020

Language：English Publishing type：Research paper (scientific journal)

Objective The burden of death from pneumonia is expected to increase with the aging of the population, as has been observed in Japan. Depressive tendency, a common psychosocial sign, may be a risk factor for pneumonia due to its possible association with some immune dysfunction. This study aimed to clarify the association between depressive tendency and the risk of death from pneumonia. Methods A population-based cohort that consisted of 75,174 Japanese men and women was followed for a median of 19.1 years. Four psychological and behavioral symptoms (depressive symptoms) were used to evaluate depressive tendency. Results A total of 1,329 deaths from pneumonia were observed. Depressive symptoms were positively and dose-dependently associated with the risk of death from pneumonia (P<0.001 for trend), and subjects with ≥2 depressive symptoms showed a significantly elevated risk compared to those without any symptoms (multivariable hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.39-1.99). This association was not significantly affected by sex or age at baseline. The elevated risk was still significant even when subjects were limited to those without any medical histories. The excess risk was observed not only for death occurring within the first 10 years of follow-up (multivariable HR, 2.05; 95% CI, 1.51-2.78) but also for that occurring in the longer follow-up period (multivariable HR, 1.48; 95% CI, 1.18-1.85). Conclusion Depressive tendency may be a risk factor for death from pneumonia. Further studies using a more reliable tool for the evaluation of depressive state are necessary to confirm this relationship.

DOI： 10.2169/internalmedicine.5052-20

Cross-sectional association between working and depression prevalence in cancer survivors: a literature review Reviewed International journal

Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

Environmental and Occupational Health Practice Vol. 2 ( 1 ) page： n/a - n/a 2020

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Reviewed International journal

Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

The American journal of clinical nutrition Vol. 110 ( 6 ) page： 1449 - 1455 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. OBJECTIVES: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. METHODS: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. RESULTS: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. CONCLUSIONS: Seaweed intake was inversely associated with risk of ischemic heart disease.

DOI： 10.1093/ajcn/nqz231

Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Reviewed

Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

Journal of epidemiology Vol. 29 ( 12 ) page： 457 - 463 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

DOI： 10.2188/jea.JE20180124

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. Reviewed

Shigehisa Kajikawa, Naoyuki Imai, Shotaro Okachi, Hiroshi Yatsuya, Tomohide Souma, Toshikazu Watanabe, Yasuhiro Goto, Tomoyuki Minezawa, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

Nagoya journal of medical science Vol. 81 ( 4 ) page： 613 - 620 2019.11

Language：English Publishing type：Research paper (scientific journal)

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUS-GS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

DOI： 10.18999/nagjms.81.4.613

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. Reviewed International coauthorship International journal

Crystal Man Ying Lee, Stephen Colagiuri, Mark Woodward, Edward W Gregg, Robert Adams, Fereidoun Azizi, Rafael Gabriel, Tiffany K Gill, Clicerio Gonzalez, Allison Hodge, David R Jacobs Jr Jr, Joshua J Joseph, Davood Khalili, Dianna J Magliano, Kirsten Mehlig, Roger Milne, Gita Mishra, Morgana Mongraw-Chaffin, Julie A Pasco, Masaru Sakurai, Pamela J Schreiner, Elizabeth Selvin, Jonathan E Shaw, Gary Wittert, Hiroshi Yatsuya, Rachel R Huxley

BMJ open diabetes research & care Vol. 7 ( 1 ) page： e000794 2019.10

Language：English Publishing type：Research paper (scientific journal)

Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results: Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions: In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

DOI： 10.1136/bmjdrc-2019-000794

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study Reviewed

Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

CANCER RESEARCH AND TREATMENT Vol. 51 ( 4 ) page： 1509 - 1517 2019.10

The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis. Reviewed International coauthorship International journal

Yan Zhang, Fangfang Hou, Jiexue Li, Haiying Yu, Lu Li, Shilian Hu, Guodong Shen, Hiroshi Yatsuya

Medicine Vol. 98 ( 42 ) page： e17513 2019.10

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. OBJECTIVE: The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. DATA SOURCE: We electronically searched PubMed, Embase, and Web of Science for articles reporting an association between weight fluctuation and all-cause mortality that were published before April 30, 2018. STUDY APPRAISAL AND SYNTHESIS METHODS: The methodological quality of each study was appraised using the modified Newcastle Ottawa Quality Assessment Scale. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled using random-effect models. Meta-regression approaches were also performed to explore sources of between-study heterogeneity. RESULTS: A total of 15 studies were eligible for the current meta-analysis. The pooled overall HR for all-cause mortality in the group with the greatest weight fluctuations compared with the most stable weight category was 1.45 (95% CI: 1.29-1.63). Considerable between-study heterogeneity was observed, some of which was partially explained by the different follow-up durations used by the included studies. Moreover, publication bias that inflated the risk of all-cause mortality was detected using Egger's test (P = .001). CONCLUSION: Weight fluctuation might be associated with an increased risk of all-cause mortality.

DOI： 10.1097/MD.0000000000017513

Differences between expected and actual length of sick leave attributable to occupational accidents. Reviewed

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能 Reviewed

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 Vol. 78回 page： 220 - 220 2019.10

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 Vol. 78回 page： 220 - 220 2019.10

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed International journal

Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

Journal of epidemiology Vol. 29 ( 9 ) page： 325 - 333 2019.9

KATOH Yoshiji, OTA Atsuhiko, YATSUYA Hiroshi

Journal of Occupational Safety and Health Vol. 12 ( 3 ) page： 173 - 179 2019.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：National Institute of Occupational Safety and Health

<p>For prevention of occupational accidents, the Labor Standards Inspection Offices evaluated the severity of the accidents based on the expected length of sick leave which was reported to the offices. Workers who met the accidents often take longer periods of sick leave than expected. We examined the excess of the length and their associations with the workers' characteristics. The subjects were 1,672 workers (1,204 men and 468 women) who met occupational accidents. 71.2% of the men and 63.9% of the women took longer periods of sick leave than expected. Men had longer expected (median: 30 days for men, 28 days for women) and actual length of sick leave (median: 50 days for men, 39 days for women) than women. The median rates of the actual sick leave periods to the expected ones were 1.38 for the men and 1.20 for the women. In men, working for the transportation/port industry, a company size of 100-299 employees, and an age of less than 30, were significantly associated with taking longer periods of sick leave than expected. The severity of occupational accidents may be underestimated if it is estimated by the expected sick leave length.</p>

DOI： 10.2486/josh.JOSH-2019-0009-CHO

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