Papers - YATSUYA Hiroshi

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 Reviewed International coauthorship International journal

Valery L Feigin, Melsew Dagne Abate, Yohannes Habtegiorgis Abate, Samar Abd ElHafeez, Foad Abd-Allah, Ahmed Abdelalim, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Arash Abdollahi, Meriem Abdoun, Rami Abd-Rabu, Deldar Morad Abdulah, Auwal Abdullahi, Mesfin Abebe, Roberto Ariel Abeldaño Zuñiga, E S Abhilash, Olugbenga Olusola Abiodun, Olumide Abiodun, Rahim Abo Kasem, Richard Gyan Aboagye, Mohamed Abouzid, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Dariush Abtahi, Samir Abu Rumeileh, Ahmed Abualhasan, Hasan Abualruz, Eman Abu-Gharbieh, Hana J Abukhadijah, Niveen ME Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Juan Manuel Acuna, Denberu Eshetie Adane, Mesafint Molla Adane, Isaac Yeboah Addo, Rufus Adesoji Adedoyin, Oyelola A Adegboye, Victor Adekanmbi, Kishor Adhikari, Qorinah Estiningtyas Sakilah Adnani, Saryia Adra, Leticia Akua Adzigbli, Abdelrahman Yousry Afify, Aanuoluwapo Adeyimika Afolabi, Fatemeh Afrashteh, Muhammad Sohail Afzal, Saira Afzal, Shahin Aghamiri, Williams Agyemang-Duah, Bright Opoku Ahinkorah, Aqeel Ahmad, Muayyad M Ahmad, Sajjad Ahmad, Shahzaib Ahmad, Tauseef Ahmad, Amir Mahmoud Ahmadzade, Ali Ahmed, Ayman Ahmed, Haroon Ahmed, Syed Anees Ahmed, Marjan Ajami, Budi Aji, Essona Matatom Akara, Rufus Olusola Akinyemi, Mohammed Ahmed Akkaif, Ashley E Akrami, Salah Al Awaidy, Hanadi Al Hamad, Syed Mahfuz Al Hasan, Mohammad Al Qadire, Omar Al Ta'ani, Yazan Al-Ajlouni, Samer O Alalalmeh, Tariq A Alalwan, Ziyad Al-Aly, Rasmieh Mustafa Al-amer, Wafa A Aldhaleei, Mohammed S Aldossary, Seyedeh Yasaman Alemohammad, Bassam Al-Fatly, Adel Ali Saeed Al-Gheethi, Fadwa Naji Alhalaiqa, Maryam Alharrasi, Abid Ali, Mohammed Usman Ali, Rafat Ali, Syed Shujait Ali, Waad Ali, Akram Al-Ibraheem, Sheikh Mohammad Alif, Syed Mohamed Aljunid, Wael Almahmeed, Sabah Al-Marwani, Mahmoud A Alomari, Jordi Alonso, Jaber S Alqahtani, Rajaa M Mohammad Al-Raddadi, Ahmad Alrawashdeh, Mohammed A Alsabri, Najim Z Alshahrani, Zaid Altaany, Awais Altaf, Alaa B Al-Tammemi, Diala Altwalbeh, Nelson Alvis-Guzman, Hassan Alwafi, Mohammad Al-Wardat, Yaser Mohammed Al-Worafi, Hany Aly, Safwat Aly, Mohammad Sharif Ibrahim Alyahya, Karem H Alzoubi, Walid Adnan Al-Zyoud, Reza Amani, Prince M Amegbor, Tewodros Getnet Amera, Tarek Tawfik Amin, Alireza Amindarolzarbi, Sohrab Amiri, Hubert Amu, Dickson A Amugsi, Ganiyu Adeniyi Amusa, Robert Ancuceanu, Deanna Anderlini, Dhanalakshmi Angappan, Abhishek Anil, Mohammed Tahir Tahir Ansari, Alireza Ansari-Moghaddam, Rockson Ansong, Saeid Anvari, Saleha Anwar, Sumadi Lukman Anwar, Ekenedilichukwu Emmanuel Anyabolo, Anayochukwu Edward Anyasodor, Geminn Louis Carace Apostol, Francis Appiah, Muhammad Aqeel, Jalal Arabloo, Razman Arabzadeh Bahri, Mosab Arafat, Aleksandr Y Aravkin, Ali Ardekani, Demelash Areda, Brhane Berhe Aregawi, Getnet Mesfin Aregu, Olatunde Aremu, Hidayat Arifin, Johan Ärnlöv, Anton A Artamonov, Judie Arulappan, Umesh Raj Aryal, Zahra Aryan, Akram M Asbeutah, Mulusew A Asemahagn, Mulu Tiruneh Asemu, Mohammad Asghari-Jafarabadi, Mubarek Yesse Ashemo, Tahira Ashraf, Armin Aslani, Haftu Asmerom Asmerom, Thomas Astell-Burt, Seyyed Shamsadin Athari, Prince Atorkey, Maha Moh'd Wahbi Atout, Alok Atreya, Avinash Aujayeb, Marcel Ausloos, Abolfazl Avan, Hamzeh Awad, Adedapo Wasiu Awotidebe, Lemessa Assefa A Ayana, Setognal Birara Aychiluhm, Amdehiwot A Aynalem, Zewdu Bishaw Aynalem, Sina Azadnajafabad, Hiva Azami, Shahkaar Aziz, Ahmed Y Azzam, Abraham Samuel Babu, Giridhara Rathnaiah Babu, Muhammad Badar, Ashish D Badiye, Pegah Bahrami Taghanaki, Saeed Bahramian, Ruhai Bai, Atif Amin Baig, Shankar M Bakkannavar, Abdulaziz T Bako, Ovidiu Constantin Baltatu, Kiran Bam, Maciej Banach, Morteza Banakar, Soham Bandyopadhyay, Palash Chandra Banik, Kannu Bansal, Yanping Bao, Miguel A Barboza, Mainak Bardhan, Noel C Barengo, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Hiba Jawdat Barqawi, Amadou Barrow, Lingkan Barua, Azadeh Bashiri, Hameed Akande Bashiru, Afisu Basiru, Mohammad-Mahdi Bastan, Sanjay Basu, Saurav Basu, Kavita Batra, Ahmet Begde, Babak Behnam, Amir Hossein Behnoush, Melesse B Y Belayneh, Michael Belingheri, Umar Muhammad Bello, Derrick A Bennett, Isabela M Bensenor, Fentaw Tadese Berhe, Amiel Nazer C Bermudez, Habtamu B B Beyene, Kebede A Beyene, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Ashish Bhalla, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Ajay Nagesh Bhat, Vivek Bhat, Gurjit Kaur Bhatti, Jasvinder Singh Singh Bhatti, Mohiuddin Ahmed Bhuiyan, Subarna Bhusal, Boris Bikbov, Cem Bilgin, Antonio Biondi, Keralem Anteneh Bishaw, Atanu Biswas, Bijit Biswas, Trupti Bodhare, Eyob Ketema Bogale, Archith Boloor, Milad Bonakdar Hashemi, Aime Bonny, Berrak Bora Basara, Hamed Borhany, Samuel Adolf Bosoka, Souad Bouaoud, Abdelhakim Bouyahya, Edward J Boyko, Marija M Bozic, Dejana Braithwaite, Susanne Breitner, Hermann Brenner, Gabrielle Britton, Andre R Brunoni, Dana Bryazka, Raffaele Bugiardini, Lemma N Bulto, Katrin Burkart, Yasser Bustanji, Zahid A Butt, Florentino Luciano Caetano dos Santos, Luis Alberto Cámera, Luciana Aparecida Campos, Ismael R Campos-Nonato, Fan Cao, Angelo Capodici, Rosario Cárdenas, Sinclair Carr, Giulia Carreras, Andre F Carvalho, Felix Carvalho, Joao Mauricio Castaldelli-Maia, Carlos A Castañeda-Orjuela, Giulio Castelpietra, Alberico L Catapano, Maria Sofia Cattaruzza, Luca Cegolon, Francieli Cembranel, Edina Cenko, Ester Cerin, Joshua Chadwick, Chiranjib Chakraborty, Sandip Chakraborty, Jeffrey Shi Kai Chan, Rama Mohan Chandika, Eeshwar K Chandrasekar, Gashaw Sisay Chanie, Vijay Kumar Chattu, Anis Ahmad Chaudhary, Akhilanand Chaurasia, Haowei Chen, Mingling Chen, Simiao Chen, Gerald Chi, Fatemeh Chichagi, Ritesh Chimoriya, Patrick R Ching, Abdulaal Chitheer, So Mi Jemma Cho, Dong-Woo Choi, Bryan Chong, Chean Lin Chong, Hitesh Chopra, Sonali Gajanan Choudhari, Rahul Choudhary, Dinh-Toi Chu, Isaac Sunday Chukwu, Sheng-Chia Chung, Zinhle Cindi, Iolanda Cioffi, Rebecca M Cogen, Alyssa Columbus, Simona Costanzo, Rosa A S Couto, Michael H Criqui, Natalia Cruz-Martins, Silvia Magali Cuadra-Hernández, Alanna Gomes da Silva, Sriharsha Dadana, Omid Dadras, Xiaochen Dai, Koustuv Dalal, Lachlan L Dalli, Giovanni Damiani, Emanuele D'Amico, Lalit Dandona, Rakhi Dandona, Amira Hamed Darwish, Saswati Das, Mohsen Dashti, Mohadese Dashtkoohi, Mohammad Dashtkoohi, Maedeh Dastmardi, Kairat Davletov, Vanessa De la Cruz-Góngora, Sean DeAngelo, Aklilu Tamire Debele, Shayom Debopadhaya, Ivan Delgado-Enciso, Berecha Hundessa Demessa, Andreas K Demetriades, Edgar Denova-Gutiérrez, Emina Dervišević, Hardik Dineshbhai Desai, Aragaw Tesfaw Desale, Fikreab Desta, Vinoth Gnana Chellaiyan Devanbu, Devananda Devegowda, Syed Masudur Rahman Dewan, Amol S Dhane, Meghnath Dhimal, Vishal R Dhulipala, Michael J Diaz, Mengistie Diress, Milad Dodangeh, Phidelia Theresa Doegah, Sushil Dohare, Mohamed Fahmy Doheim, Klara Georgieva Dokova, Deepa Dongarwar, Mario D'Oria, Ojas Prakashbhai Doshi, Rajkumar Prakashbhai Doshi, Abdel Douiri, Robert Kokou Dowou, Ashel Chelsea Dsouza, Haneil Larson Dsouza, Viola Savy Dsouza, Bruce B Duncan, Andre Rodrigues Duraes, Arkadiusz Marian Dziedzic, Michael Ekholuenetale, Ibrahim Farahat El Bayoumy, Maysaa El Sayed Zaki, Iffat Elbarazi, Faris El-Dahiyat, Islam Y Elgendy, Muhammed Elhadi, Waseem El-Huneidi, Mohamed A Elmonem, Adel B Elmoselhi, Chadi Eltaha, Theophilus I Emeto, Christopher Imokhuede Esezobor, Negin Esfandiari, Zahra Esmaeili, Francesco Esposito, Mohammad Etoom, Natalia Fabin, Ibtihal Fadhil, Adeniyi Francis Fagbamigbe, Omotayo Francis Fagbule, Shahriar Faghani, Ayesha Fahim, Ildar Ravisovich Fakhradiyev, Luca Falzone, Mohammad Fareed, Jawad Fares, Carla Sofia e Sá Farinha, MoezAlIslam Ezzat Mahmoud Faris, Pawan Sirwan Faris, Mohsen Farjoud Kouhanjani, Andre Faro, Hossein Farrokhpour, Abidemi Omolara Fasanmi, Nelsensius Klau Fauk, Patrick Fazeli, Timur Fazylov, Alireza Feizkhah, Ginenus Fekadu, Xiaoqi Feng, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Getahun Fetensa, Bikila Regassa Feyisa, Florian Fischer, Luisa S Flor, Kristen Marie Foley, Ana Catarina Fonseca, Roham Foroumadi, Behzad Foroutan, Daniela Fortuna, Matteo Foschi, Richard Charles Franklin, Ni Kadek Yuni Fridayani, Sridevi G, Peter Andras Gaal, Abhay Motiramji Gaidhane, Abduzhappar Gaipov, Yaseen Galali, Silvano Gallus, Aravind P Gandhi, Balasankar Ganesan, Danijela Gasevic, Prem Gautam, Rupesh K Gautam, Miglas Welay Gebregergis, Mesfin Gebrehiwot, Kebre Gebrekirstos Gebrekidan, Lemma Getacher, Genanew K Getahun, Molla Getie, Delaram J Ghadimi, Fataneh Ghadirian, Amir Ghaffari Jolfayi, Mansour Ghafourifard, Mohammad-Reza Ghasemi, Afsaneh Ghasemzadeh, Ramy Mohamed Ghazy, Ehsan Gholami, Zainab Gholami, Sherief Ghozy, Stefano Giannoni Luza, Jaleed Ahmed Gilani, Tiffany K Gill, Richard F Gillum, Ebisa Zerihun Gindaba, Elena V Gnedovskaya, Amit Goel, Mohamad Goldust, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Philimon N Gona, Giuseppe Gorini, Alessandra C Goulart, Barbara Niegia Garcia Goulart, Mahdi Gouravani, Michal Grivna, Giuseppe Grosso, Ashna Grover, Shi-Yang Guan, Giovanni Guarducci, Avirup Guha, Stefano Guicciardi, Snigdha Gulati, Damitha Asanga Gunawardane, Cui Guo, Zhifeng Guo, Anish Kumar Gupta, Bhawna Gupta, Mohak Gupta, Rahul Gupta, Rajat Das Gupta, Rajeev Gupta, Sapna Gupta, Farrokh Habibzadeh, Najah R Hadi, Mohammad Haghani Dogahe, Hamed Haghi-Aminjan, Dariush Haghmorad, Arvin Haj-Mirzaian, Aram Halimi, Nadia M Hamdy, Samer Hamidi, Erin B Hamilton, Asif Hanif, Nasrin Hanifi, Graeme J Hankey, Md Abdul Hannan, Zaim Anan Haq, Arief Hargono, Netanja I Harlianto, Josep Maria Haro, Eka Mishbahatul Marah Has, Ahmed I Hasaballah, Ikramul Hasan, Md Saquib Hasnain, Ikrama Hassan, Mahgol Sadat Hassan Zadeh Tabatabaei, Johannes Haubold, Rasmus J Havmoeller, Simon I Hay, Youssef Hbid, Jeffrey J Hebert, Omar E Hegazi, Mohammad Heidari, Mehdi Hemmati, Demisu Zenbaba Heyi, Kamal Hezam, Yuta Hiraike, Nguyen Quoc Hoan, Ramesh Holla, Nobuyuki Horita, Md Mahbub Hossain, Hassan Hosseinzadeh, Mehdi Hosseinzadeh, Ahmad Hosseinzadeh Adli, Mihaela Hostiuc, Sorin Hostiuc, Ben Hu, Chengxi Hu, Junjie Huang, Ayesha Humayun, Salman Hussain, Le Duc Huy, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Nayu Ikeda, Adalia Ikiroma, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Mohammad Tarique Imam, Mustapha Immurana, Leeberk Raja Inbaraj, Muhammad Iqhrammullah, Arnaud Iradukunda, Lalu Muhammad Irham, Md Rabiul Islam, Faisal Ismail, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Ramaiah Itumalla, Masao Iwagami, Chidozie Declan CD Iwu, Vinothini J, Jalil Jaafari, Louis Jacob, Abdollah Jafarzadeh, Haitham Jahrami, Akhil Jain, Nityanand Jain, Ammar Abdulrahman Jairoun, Abhishek Jaiswal, Mihajlo Jakovljevic, Reza Jalilzadeh Yengejeh, Balamurugan Janakiraman, Abubakar Ibrahim Jatau, Sathish Kumar Jayapal, Shubha Jayaram, Sun Ha Jee, Jayakumar Jeganathan, Mihretu Jegnie, Alelign Tasew Jema, Bijay Mukesh Jeswani, Angeline Jeyakumar, Anil K Jha, Ravi Prakash Jha, Zixiang Ji, Heng Jiang, Shuai Jin, Yingzhao Jin, Mohammad Jokar, Jost B Jonas, Tamas Joo, Jobinse Jose, Nitin Joseph, Charity Ehimwenma Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jürisson, Ali Kabir, Md Awal Kabir, Zubair Kabir, Vidya Kadashetti, Rizwan Kalani, Sanjay Kalra, Vineet Kumar Kamal, Arun Kamireddy, Haidong Kan, Mona Kanaan, Himal Kandel, Kehinde Kazeem Kanmodi, Rami S Kantar, Neeti Kapoor, Paschalis Karakasis, Ibraheem M Karaye, André Karch, Hanie Karimi, Salah Eddin Karimi, Yeganeh Karimi, Arman Karimi Behnagh, Prabin Karki, Hengameh Kasraei, Joonas H Kauppila, Harkiran Kaur, Neda Kaydi, Gbenga A Kayode, Foad Kazemi, Sina Kazemian, Emmanuelle Kesse-Guyot, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Inn Kynn Khaing, Himanshu Khajuria, Amirmohammad Khalaji, Nauman Khalid, Anees Ahmed Khalil, Asaduzzaman Khan, Fayaz Khan, M Nuruzzaman Khan, Maseer Khan, Mohammad Jobair Khan, Moien AB Khan, Yusra H Khan, Shaghayegh Khanmohammadi, Khaled Khatab, Haitham Khatatbeh, Moawiah Mohammad Khatatbeh, Sorour Khateri, Mahalaqua Nazli Khatib, Maryam Khayamzadeh, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Manoj Khokhar, Atulya Aman Khosla, Majid Khosravi, Jagdish Khubchandani, Saeid Kian, Kwanghyun Kim, Min Seo Kim, Yun Jin Kim, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Ali-Asghar Kolahi, Kamrun Nahar Koly, Farzad Kompani, Shivakumar KM Marulasiddaiah Kondlahalli, Miikka Korja, Vladimir Andreevich Korshunov, Oleksii Korzh, Soewarta Kosen, Karel Kostev, Nikhil Kothari, Ashwin Laxmikant Kotnis, Sindhura Lakshmi Koulmane Laxminarayana, Kewal Krishan, Varun Krishna, Vijay Krishnamoorthy, Bindu Krishnan, Jera Kruja, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Md Abdul Kuddus, Mohammed Kuddus, Nuworza Kugbey, Mukhtar Kulimbet, Vishnutheertha Kulkarni, Akshay Kumar, Ashish Kumar, Dewesh Kumar, G Anil Kumar, Nithin Kumar, Rakesh Kumar, Senthil Kumaran D, Amartya Kundu, Satyajit Kundu, Setor K Kunutsor, Om P Kurmi, Dian Kusuma, L V Simhachalam Kutikuppala, Ambily Kuttikkattu, Ville Kytö, Carlo La Vecchia, Ben Lacey, Chandrakant Lahariya, Dharmesh Kumar Lal, Tea Lallukka, Judit Lám, Iván Landires, Anders O Larsson, Savita Lasrado, Kaveh Latifinaibin, Paolo Lauriola, Pablo M Lavados, Basira Kankia Lawal, Long Khanh Dao Le, Nhi Huu Hanh Le, Thao Thi Thu Le, Trang Diep Thanh Le, Paul H Lee, Seung Won Lee, Wei-Chen Lee, Yo Han Lee, Ming-Chieh Li, Wei Li, Xiaopan Li, Yichong Li, Lee-Ling Lim, Stephen S Lim, John C Lin, Daniel Lindholm, Shai Linn, Gang Liu, Runben Liu, Shuke Liu, Xiaofeng Liu, Xuefeng Liu, Erand Llanaj, Chun-Han Lo, Warren David Lo, Valerie Lohner, José Francisco López-Gil, László Lorenzovici, Stefan Lorkowski, Paulo A Lotufo, Giancarlo Lucchetti, Lisha Luo, Jay B Lusk, Zheng Feei Ma, Monika Machoy, Farzan Madadizadeh, Ralph Maddison, Elham Mahmoudi, Golnaz Mahmoudvand, Omar M Makram, Elaheh Malakan Rad, Kashish Malhotra, Ahmad Azam Malik, Iram Malik, Tauqeer Hussain Mallhi, Deborah Carvalho Malta, Abdullah A Mamun, Yosef Manla, Mohammad Hadi Mansouri, Pejman Mansouri, Vahid Mansouri, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Emmanuel Manu, Hamid Reza Marateb, Abdoljalal Marjani, Daniela Martini, Santi Martini, Miquel Martorell, Sharmeen Maryam, Roy Rillera Marzo, Awoke Masrie, Yasith Mathangasinghe, Pallab K Maulik, Mahsa Mayeli, Mohsen Mazidi, Martin McKee, Steven M McPhail, Enkeleint A Mechili, Asim Mehmood, Kamran Mehrabani-Zeinabad, Tesfahun Mekene Meto, Hadush Negash Meles, Walter Mendoza, Ritesh G Menezes, George A Mensah, Sultan Ayoub Meo, Atte Meretoja, Tuomo J Meretoja, Tomislav Mestrovic, Chamila Dinushi Kukulege Mettananda, Tomasz Miazgowski, Irmina Maria Michalek, Ana Carolina Micheletti Gomide Nogueira de Sá, Giuseppe Minervini, Le Huu Nhat Minh, GK Mini, Mojgan Mirghafourvand, Andreea Mirica, Erkin M Mirrakhimov, Mohammad Mirza-Aghazadeh-Attari, Manish Mishra, Sanjeev Misra, Prasanna Mithra, Ahmed Ismail Mohamed, Jama Mohamed, Nouh Saad Mohamed, Ameen Mosa Mohammad, Esmaeil Mohammadi, Saeed Mohammadi, Soheil Mohammadi, Abdollah Mohammadian-Hafshejani, Ibrahim Mohammadzadeh, Hussen Mohammed, Mustapha Mohammed, Salahuddin Mohammed, Shafiu Mohammed, Ali H Mokdad, Hossein Molavi Vardanjani, Mariam Molokhia, Shaher Momani, Lorenzo Monasta, Mohammad Ali Moni, Fateme Montazeri, AmirAli Moodi Ghalibaf, Mahmood Moosazadeh, Maryam Moradi, Yousef Moradi, Paula Moraga, Lidia Morawska, Rafael Silveira Moreira, Shane Douglas Morrison, Reza Mosaddeghi Heris, Elias Mossialos, Parsa Mousavi, Ahmed Msherghi, Sumaira Mubarik, Lorenzo Muccioli, Admir Mulita, Malaisamy Muniyandi, Kavita Munjal, Efren Murillo-Zamora, Sathish Muthu, Woojae Myung, Amin Nabavi, Ashraf Fawzy Nabhan, Ayoub Nafei, Ahamarshan Jayaraman Nagarajan, Pirouz Naghavi, Ganesh R Naik, Gurudatta Naik, Mukhammad David Naimzada, Sanjeev Nair, Tapas Sadasivan Nair, Soroush Najdaghi, Hastyar Hama Rashid Najmuldeen, Noureddin Nakhostin Ansari, Vinay Nangia, Sreenivas Narasimha Swamy, Shumaila Nargus, Delaram Narimani Davani, Bruno Ramos Nascimento, Gustavo G Nascimento, Ali Nasrollahizadeh, Amir Nasrollahizadeh, Zuhair S Natto, Javaid Nauman, Samidi Nirasha Kumari Navaratna, Biswa Prakash Nayak, Vinod C Nayak, Athare Nazri-Panjaki, Rawlance Ndejjo, Ionut Negoi, Ruxandra Irina Negoi, Seyed Aria Nejadghaderi, Chakib Nejjari, Mohammad Hadi Nematollahi, Samata Nepal, Charles Richard James Newton, Dang H Nguyen, Duc Hoang Nguyen, Hau Thi Hien Nguyen, Hien Quang Nguyen, Nhien Ngoc Y Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Robina Khan Niazi, Yeshambel T Nigatu, Nasrin Nikravangolsefid, Dina Nur Anggraini Ningrum, Chukwudi A Nnaji, Lawrence Achilles Nnyanzi, Shuhei Nomura, Syed Toukir Ahmed Noor, Bo Norrving, Nawsherwan Nawsherwan, Jean Jacques Noubiap, Chisom Adaobi Nri-Ezedi, George Ntaios, Mpiko Ntsekhe, Fred Nugen, Mario Cesare Nurchis, Dieta Nurrika, Chimezie Igwegbe Nzoputam, Ogochukwu Janet Nzoputam, Bogdan Oancea, Kehinde O Obamiro, Ismail A Odetokun, Martin James O'Donnell, James Odhiambo Oguta, In-Hwan Oh, Tolulope R Ojo-Akosile, Hassan Okati-Aliabad, Sylvester Reuben Okeke, Akinkunmi Paul Okekunle, Lawrence Okidi, Osaretin Christabel Okonji, Morteza Oladnabi, Andrew T Olagunju, Muideen Tunbosun Olaiya, Oladotun Victor Olalusi, Tosin Abiola Olasehinde, Omotola O Olasupo, Matthew Idowu Olatubi, Arão Belitardo Oliveira, Gláucia Maria Moraes Oliveira, Abdulhakeem Abayomi Olorukooba, Isaac Iyinoluwa Olufadewa, Yinka Doris Doris Oluwafemi, Gideon Olamilekan Oluwatunase, Hany A Omar, Ahmed Omar Bali, Adrienne E O'Neil, Sok King Ong, Obinna E Onwujekwe, Abdulahi Opejin Opejin, Michal Ordak, Raffaele Ornello, Doris V Ortega-Altamirano, Alberto Ortiz, Esteban Ortiz-Prado, Wael M S Osman, Uchechukwu Levi Osuagwu, Stanislav S Otstavnov, Mayowa O Owolabi, Ifeoluwa Temitayo Oyeyemi, Ahmad Ozair, Mahesh Padukudru P A, Kevin Pacheco-Barrios, Alicia Padron-Monedero, Jagadish Rao Padubidri, Tamás Palicz, Raul Felipe Palma-Alvarez, Feng Pan, Songhomitra Panda-Jonas, Deepshikha Pande Katare, Anamika Pandey, Ashok Pandey, Seithikurippu R Pandi-Perumal, Leonidas D Panos, Ioannis Pantazopoulos, Paraskevi Papadopoulou, Shahina Pardhan, Pragyan Paramita Parija, Romil R Parikh, Nicholas Parsons, Roberto Passera, Dimitrios Patoulias, Uttam Paudel, Shrikant Pawar, Amy E Peden, Paolo Pedersini, Prince Peprah, Maria Odete Pereira, Mario F P Peres, Arokiasamy Perianayagam, Norberto Perico, Simone Perna, Richard G Pestell, Ionela-Roxana Petcu, Fanny Emily Petermann-Rocha, Hoang Nhat Pham, Hoang Tran Pham, Michael R Phillips, Thomas Pilgrim, Michael A Piradov, Saeed Pirouzpanah, Evgenii Plotnikov, Dimitri Poddighe, Ramesh Poluru, Djordje S Popovic, Maarten J Postma, Akram Pourshams, Naeimeh Pourtaheri, Jalandhar Pradhan, Pranil Man Singh Pradhan, V Prakash, Manya Prasad, Elton Junio Sady Prates, Dimas Ria Angga Pribadi, Jagadeesh Puvvula, Ibrahim Qattea, Gangzhen Qian, Yanan Qiao, Alberto Raggi, Pankaja Raghav Raghav, Pracheth Raghuveer, Fakher Rahim, Md Jillur Rahim, Mahban Rahimifard, Vafa Rahimi-Movaghar, Md Mosfequr Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Mohammad Rahmanian, Nazanin Rahmanian, Vahid Rahmanian, Rahem Rahmati, Setyaningrum Rahmawaty, Gerard Marshall Raj, Sathish Rajaa, Vinoth Rajendran, Pushp Lata Rajpoot, Prashant Rajput, Pradhum Ram, Mahmoud Mohammed Ramadan, Majed Ramadan, Venkitachalam Ramanarayanan, Shakthi Kumaran Ramasamy, Sheena Ramazanu, Juwel Rana, Kritika Rana, Rishabh Kumar Rana, Chhabi Lal Ranabhat, Nemanja Rancic, Amey Rane, Annemarei Ranta, Mithun Rao, Sowmya J Rao, Sina Rashedi, Mohammad-Mahdi Rashidi, Ashkan Rasouli-Saravani, Devarajan Rathish, Santosh Kumar Rauniyar, Salman Rawaf, Christian Razo, Murali Mohan Rama Krishna Reddy, Elrashdy Moustafa Mohamed Redwan, Inayat Ur Rehman, Giuseppe Remuzzi, Nazila Rezaei, Mohsen Rezaeian, Hossein Rezazadeh, Taeho Gregory Rhee, Mavra A Riaz, Antonio Luiz P Ribeiro, Monica Rodrigues, Thales Philipe R Rodrigues da Silva, Jefferson Antonio Buendia Rodriguez, Leonardo Roever, Debby Syahru Romadlon, Allen Guy Ross, Himanshu Sekhar Rout, Bedanta Roy, Priyanka Roy, Simanta Roy, Guilherme de Andrade Ruela, Michele Russo, Godfrey M Rwegerera, Chandan S N, Aly M A Saad, Korosh Saber, Maha Mohamed Saber-Ayad, Cameron John Sabet, Siamak Sabour, Simona Sacco, Basema Ahmad Saddik, Erfan Sadeghi, Mohammad Reza Saeb, Umar Saeed, Sher Zaman Zaman Safi, Rajesh Sagar, Alireza Saghafi, Dominic Sagoe, Fatemeh Saheb Sharif-Askari, Amirhossein Sahebkar, Pragyan Monalisa Sahoo, Soumya Swaroop Sahoo, Mirza Rizwan Sajid, Afeez Abolarinwa Salami, Luciane B Salaroli, Mohamed A Saleh, Mohammed Z Y Salem, Giovanni A Salum, Sara Samadzadeh, Saad Samargandy, Yoseph Leonardo Samodra, Vijaya Paul Samuel, Abdallah M Samy, Juan Sanabria, Itamar S Santos, Milena M Santric-Milicevic, Made Ary Sarasmita, Aswini Saravanan, Yaser Sarikhani, Gargi Sachin Sarode, Sachin C Sarode, Maheswar Satpathy, Zafer Sattouf, Ganesh Kumar Saya, Md Abu Sayeed, Mehdi Sayyah, Nikolaos Scarmeas, Benedikt Michael Schaarschmidt, Markus P Schlaich, Maria Inês Schmidt, Ione Jayce Ceola Schneider, Art Schuermans, Austin E Schumacher, Aletta Elisabeth Schutte, David C Schwebel, Siddharthan Selvaraj, Parijat Sen, Sabyasachi Senapati, Subramanian Senthilkumaran, Mihretu Tagesse Sergindo, Yashendra Sethi, Allen Seylani, Mahan Shafie, Pritik A Shah, Saeed Shahabi, Ataollah Shahbandi, Samiah Shahid, Hamid R Shahsavari, Moyad Jamal Shahwan, Masood Ali Shaikh, Ali S Shalash, Muhammad Aaqib Shamim, Mehran Shams-Beyranvand, Anas Shamsi, Alfiya Shamsutdinova, Mohd Shanawaz, Mohammed Shannawaz, Medha Sharath, Amin Sharifan, Azam Sharifi, Javad Sharifi-Rad, Anupam Sharma, Manoj Sharma, Sourabh Sharma, Ujjawal Sharma, Vishal Sharma, Rahim Ali Sheikhi, Adithi Shetty, Mahabalesh Shetty, Premalatha K Shetty, Desalegn Shiferaw, Mika Shigematsu, Tariku Shimels, Min-Jeong Shin, Rahman Shiri, Aminu Shittu, Abdul-karim Olayinka Shitu, Ivy Shiue, Seyed Afshin Shorofi, Sunil Shrestha, Kerem Shuval, Yafei Si, Emmanuel Edwar Siddig, Mithun Sikdar, João Pedro Silva, Luís Manuel Lopes Rodrigues Silva, Abhinav Singh, Baljinder Singh, Garima Singh, Harmanjit Singh, Jasvinder A Singh, Kuldeep Singh, Narinder Pal Singh, Paramdeep Singh, Puneetpal Singh, Jussi O T Sipilä, Shravan Sivakumar, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, David A Sleet, Farrukh Sobia, Bogdan Socea, Abdullah Al Mamun Sohag, Ranjan Solanki, Shipra Solanki, Yerukneh Solomon, Yi Song, Soroush Soraneh, Reed J D Sorensen, Houman Sotoudeh, Ireneous N Soyiri, Michael Spartalis, Chandrashekhar T Sreeramareddy, Suresh Kumar Srinivasamurthy, Panagiotis Stachteas, Lauryn K Stafford, Benjamin A Stark, Antonina V Starodubova, Narayan Subedi, Vetriselvan Subramaniyan, Muhammad Suleman, Abida Sultana, Zhong Sun, Johan Sundström, Vinay Suresh, Sri Susanty, Chandan Kumar Swain, Lukasz Szarpak, Sree Sudha T Y, Payam Tabaee Damavandi, Rafael Tabarés-Seisdedos, Seyyed Mohammad Tabatabaei, Shima Tabatabai, Celine Tabche, Mohammad Tabish, Jyothi Tadakamadla, Santosh Kumar Tadakamadla, Amirmasoud Taheri, Jabeen Taiba, Iman M Talaat, Ashis Talukder, Mircea Tampa, Jacques Lukenze Tamuzi, Ker-Kan Tan, Haosu Tang, Manoj Tanwar, Ingan Ukur Tarigan, Elvis Enowbeyang Tarkang, Nathan Y Tat, Seyed Mohammad Tavangar, Arash Tehrani-Banihashemi, Mojtaba Teimoori, Mohamad-Hani Temsah, Reem Mohamad Hani Temsah, Masayuki Teramoto, Wegen Beyene Tesfamariam, Edosa Geta Tesfaye Gta, Ramna Thakur, Pugazhenthan Thangaraju, Rajshree Thapa, Rekha Thapar, Rasiah Thayakaran, Sathish Thirunavukkarasu, Joe Thomas, Nikhil Kenny Kenny Thomas, Amanda G Thrift, Jing Tian, Ales Tichopad, Jansje Henny Vera Ticoalu, Chalachew Tiruneh, Krishna Tiwari, Amir Tiyuri, Marcello Tonelli, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Khaled Trabelsi, Ngoc Ha Tran, Thang Huu Tran, Nguyen Tran Minh Duc, Domenico Trico, Samuel Joseph Tromans, Thien Tan Tri Tai Truyen, Daniel Hsiang-Te Tsai, Aristidis Tsatsakis, Evangelia Eirini Tsermpini, Ermias A A Turuse, Stefanos Tyrovolas, Aniefiok John Udoakang, Arit Udoh, Atta Ullah, Sana Ullah, Muhammad Umair, Muhammad Umar, Brigid Unim, Bhaskaran Unnikrishnan, Daniele Urso, Jibrin Sammani Usman, Marco Vacante, Seyed Mohammad Vahabi, Sanaz Vahdati, Asokan Govindaraj Vaithinathan, Omid Vakili, Rohollah Valizadeh, Jef Van den Eynde, Orsolya Varga, Shoban Babu Varthya, Tommi Juhani Vasankari, Balachandar Vellingiri, Narayanaswamy Venketasubramanian, Madhur Verma, Massimiliano Veroux, Georgios-Ioannis Verras, Dominique Vervoort, Jorge Hugo Villafañe, Simona Villani, Manish Vinayak, Maria Viskadourou, Simona Ruxandra Volovat, Victor Volovici, Hatem A Wafa, Yasir Waheed, Waseem Wahood, Cong Wang, Fang Wang, Shu Wang, Song Wang, Yanzhong Wang, Yuan-Pang Wang, Mary Njeri Wanjau, Muhammad Waqas, Emebet Gashaw Wassie, Gizachew Tadesse Wassie, Zihan Wei, Robert G Weintraub, Haftom Legese Weldetinsaa, Dakshitha Praneeth Wickramasinghe, Nuwan Darshana Wickramasinghe, Tissa Wijeratne, Peter Willeit, Charles D A Wolfe, Yen Jun Wong, Utoomporn Wongsin, Chenkai Wu, Felicia Wu, YaJuan Wu, Zenghong Wu, Hong Xiao, Suowen Xu, Xiaoyue Xu, Kazumasa Yamagishi, Danting Yang, Yuichiro Yano, Amir Yarahmadi, Habib Yaribeygi, Yuichi Yasufuku, Hiroshi Yatsuya, Fereshteh Yazdanpanah, Mohammad Hosein Yazdanpanah, Pengpeng Ye, Renjulal Yesodharan, Saber Yezli, Siyan Yi, Xinglin Yi, Dehui Yin, Dong Keon Yon, Naohiro Yonemoto, Chuanhua Yu, Elaine A Yu, Ke Yun, Hadiza Yusuf, Siddhesh Zadey, Nima Zafari, Burhan Abdullah Zaman, Sojib Bin Zaman, Aurora Zanghì, Iman Zare, Fatemeh Zarimeidani, Armin Zarrintan, Michael Zastrozhin, Dawit Zemedikun, Youjie Zeng, Beijian Zhang, Haijun Zhang, Liqun Zhang, Yunquan Zhang, Zhiqiang Zhang, Hanqing Zhao, Claire Chenwen Zhong, Shang Cheng Zhou, Bin Zhu, Lei Zhu, Abzal Zhumagaliuly, Makan Ziafati, Magdalena Zielińska, Yossef Teshome Zikarg, Ghazal Zoghi, Sa'ed H Zyoud, Samer H Zyoud, Catherine O Johnson, Gregory A Roth, Balakrishnan Sukumaran Nair, Ilari Rautalin, Anjali Bhati, Catherine Bisignano, Theo Vos, Christopher J L Murray

The Lancet Neurology   Vol. 23 ( 10 ) page： 973 - 1003   2024.10

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DOI： 10.1016/s1474-4422(24)00369-7

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Association between predicted level of water turnover deficit and all-cause and cause-specific mortalities among Japanese adults: The Japan Collaborative Cohort Study Reviewed International journal

Daiki Watanabe, Isao Muraki, Hiroshi Yatsuya, Akiko Tamakoshi

The American Journal of Clinical Nutrition     2024.9

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DOI： 10.1016/j.ajcnut.2024.09.021

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Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers’ Cohort Study Reviewed

Jingyi Lin, Zean Song, Yuanying Li, Chifa Chiang, Yoshihisa Hirakawa, Yoshihisa Nakano, Young-Jae Hong, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

Journal of Epidemiology   Vol. 34 ( 9 ) page： 428 - 433   2024.9

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Epidemiological Association  

<p><b>Background:</b> The term “nonrestorative sleep (NRS)” refers to an unrefreshed feeling at wake-up and is a domain of poor sleep quality. Previous research has demonstrated that NRS is linked to a number of diseases and adverse health outcomes, but less is known regarding the link between NRS and diabetes, particularly in Japanese.</p><p><b>Methods:</b> We studied 3,665 middle-aged male participants of the Aichi Workers’ Cohort Study who were followed-up from 2002 through 2019. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS adjusted for potential confounding variables.</p><p><b>Results:</b> During a median follow-up of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to participants without NRS (9.3/1,000 person-years). In the fully adjusted model, individuals who reported having NRS had a significantly higher risk of developing T2DM (HR1.36; 95% CI, 1.10–1.67). The association was observed only in participants under 50 years old (HR 1.82; 95% CI, 1.36–2.43), not in the older (50 years or older) participants (<i>P</i> for interaction = 0.025). In contrast, stratified analyses by the presence of shift work, obesity, or sleep duration showed similar associations in all the strata.</p><p><b>Conclusion:</b> NRS was associated with higher risk of T2DM in middle-aged Japanese male workers independent of a variety of lifestyle factors and other sleep problems.</p>

DOI： 10.2188/jea.JE20230184

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Mortality after partner’s cancer diagnosis or death: A population-based prospective cohort study in Japan Reviewed

Makiuchi Takeshi, Kakizaki Masako, Sobue Tomotaka, Kitamura Tetsuhisa, Yatsuya Hiroshi, Yamaji Taiki, Iwasaki Motoki, inoue Manami, Tsugane Shoichiro, Sawada Norie

Journal of Epidemiology   Vol. advpub ( 0 )   2024.8

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Epidemiological Association  

<p><b>Background:</b> The health statuses of closely connected individuals are interdependent. Little is known about mortality risk associated with partner’s cancer diagnosis and cause-specific mortality risk associated with partner’s death.</p><p><b>Methods:</b> Relative risks for all-cause and cause-specific mortality following a partner’s cancer diagnosis or death compared to the period when the partner is cancer-free and alive were investigated in the population-based prospective cohort study that enrolled 140,420 people at the age between 40-69 in 1990-1994.</p><p><b>Results:</b> 55,050 participants (27,665 men and 27,385 women) who were identified as married couples were followed-up for 1,073,746.1 (518,368.5 in men and 555,377.6 in women) person-years, during which 9,816 deaths (7,217 in men and 2,599 in women) were observed. After a partner’s cancer diagnosis, the mortality rate ratio (MRR) of all-cause mortality was not increased among both men and women, while an increase of externally-caused MRR was observed. The suicide MRR significantly increased among men (MRR = 2.90 [95% CI, 1.70–4.93]) and it persisted for more than 5 years. After a partner’s death, the MRRs of all-cause, cardiovascular disease (CVD), respiratory disease (RD), and externally-caused mortality significantly increased only among men. Stratified analysis by smoking status among men showed significantly increased MRRs of CVD and RD mortality among former/current smokers, but not among never-smokers.</p><p><b>Conclusion:</b> Partner’s cancer diagnosis did not increase all-cause mortality risk, but increased externally-caused mortality risk, especially suicide among men. The impact of partner’s death on mortality risk differed by the mortality causes and sex, and smoking affected some of cause-specific mortality risk.</p>

DOI： 10.2188/jea.JE20240114

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Impact of diabetes on mortality and hospitalization after dementia diagnosis: Health insurance claims data analysis Reviewed

Masaaki Matsunaga, Shinichi Tanihara, Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota

Geriatrics &amp; Gerontology International   Vol. 24 ( 8 ) page： 773 - 781   2024.8

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

Aim

Japan faces a public health challenge of dementia, further complicated by the increasing complications from diabetes within its rapidly aging population. This study assesses the impact of diabetes on mortality and hospitalization among individuals aged ≥75 years with new dementia diagnoses.

Methods

We analyzed administrative claims data in Japan from 73 324 individuals aged ≥75 years with dementia, of whom 17% had comorbid diabetes. Dementia and diabetes were identified from the International Classification of Diseases, Tenth Revision codes. We used Kaplan–Meier survival analysis, Cox proportional hazards analysis, and population attributable fractions (PAFs) to evaluate the impact on mortality and hospitalization after dementia diagnosis.

Results

One‐year mortality and 1‐year hospitalization probabilities in individuals with dementia and diabetes (10.3% and 31.7%, respectively) were higher than those without diabetes (8.3% and 25.4%, respectively). The adjusted hazard ratios for individuals with diabetes, as compared to those without, were 1.126 (95% confidence interval [CI], 1.040–1.220) for mortality and 1.191 (95% CI, 1.140–1.245) for hospitalization. The PAFs from the comorbidity of dementia and diabetes were 2.2% for mortality and 3.1% for hospitalization. Subgroup analysis showed that the PAFs were highest in men aged 75–79 years and women aged 80–84 years for mortality and in individuals aged 75–79 for hospitalization.

Conclusion

During the early postdiagnosis period, comorbid diabetes increases mortality and hospitalization risks in older adults with dementia. The variation in disease burden across age groups underscores the need for age‐specific health care strategies to manage comorbid diabetes in individuals with dementia. Geriatr Gerontol Int 2024; 24: 773–781.

DOI： 10.1111/ggi.14926

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Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer. Reviewed

Imamura Y, Kato T, Nomata Y, Okado S, Watanabe H, Kawasumi Y, Nakanishi K, Kadomatsu Y, Ueno H, Nakamura S, Mizuno T, Hase T, Tanaka I, Ishii M, Yatsuya H, Chen-Yoshikawa TF

Anticancer research   Vol. 44 ( 8 ) page： 3451 - 3461   2024.8

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Background/Aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSCLC remain unclear. The objective of the study was to compare the efficacy of ICIs and chemotherapy with conventional chemotherapy only in patients with postoperative recurrence of epidermal growth factor receptor (EGFR) wild-type NSCLC. Patients and Methods: A retrospective analysis was performed on patients who underwent anatomical lung resection at the Nagoya University Hospital and were treated for postoperative recurrence of wild-type EGFR NSCLC. This study evaluated the prognosis for postoperative recurrence, including ICIs treatment and other clinicopathological factors. Results: Of the 83 patients included in the analysis, 20 patients underwent chemotherapy and 63 patients underwent chemotherapy combined with ICIs. The combination of ICIs and chemotherapy significantly prolonged survival after recurrence (median survival: 33.1 months vs. 22.0 months, p=0.01). In the ICIs group, no significant differences in survival were detected between patients with different programmed death ligand 1 (PD-L1) status (Tumor Proportion Scores: <1%, 1%-49%, ≥50%, p=0.27). Multivariate analysis revealed that postoperative distant recurrence was a significant poor prognostic factor for survival after recurrence (HR=1.85, 95% CI=1.06-3.25, p=0.03), and combining ICIs with chemotherapy significantly improved survival after recurrence (HR=0.43, 95% CI=0.24-0.78, p<0.01). Conclusion: Combination of ICIs with chemotherapy significantly prolonged survival of postoperative recurrence with wild-type EGFR NSCLC regardless of PD-L1 status.

DOI： 10.21873/anticanres.17165

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Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

Journal of atherosclerosis and thrombosis   Vol. advpub ( 0 )   2024.7

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japan Atherosclerosis Society  

AIM: The constellation of cardiovascular disease (CVD) risk factors greatly impacts the lifetime risk (LTR) of incident CVD, but the LTR has not been thoroughly evaluated in the Japanese population. METHODS: We conducted a prospective study involving a total of 25,896 individuals 40-69 years old without a history of CVD in 1995 (Cohort I) and 1993-1994 (Cohort II) in Japan. CVD risk factors (blood pressure, non-high-density lipoprotein [HDL] cholesterol levels, smoking status, and glucose concentrations) were used to stratify them by risk. The sex-specific LTR of incident coronary heart disease, stroke, atherosclerotic CVD, and total CVD were estimated for participants 45 years old in the 4 risk categories with the cumulative incidence rate, adjusting for the competing risk of death. RESULTS: We found apparent differences in the LTR of total CVD according to the risk stratification. Individuals with ≥ 2 of the risk factors of blood pressure ≥ 140/90 mmHg or treated, non-HDL cholesterol level ≥ 170 mg/dL or treated, current smoker, and diabetes had substantially higher adjusted LTRs of CVD than those in other groups, with a LTR of 26.5% (95% confidence interval, 24.0%-29.0%) for men and 15.3% (13.1%-17.5%) for women at 45 years. The LTR of incident stroke was the highest among CVDs, and the presence of hypertension and diabetes mellitus strongly influenced the LTR of total CVD. CONCLUSION: The impact of risk accumulation on LTR of CVD was greater in men, and 1 in 4 men with ≥ 2 major risk factors at 45 years of age developed CVD in their lifetime.

DOI： 10.5551/jat.64934

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Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study Reviewed

Young Jae Hong, Rei Otsuka, Zean Song, Chisato Fukuda, Rina Tajima, Jingyi Lin, Mizuho Hibino, Mei Kobayashi, Yupeng He, Masaaki Matsunaga, Atsuhiko Ota, Yoshihisa Nakano, Yuanying Li, Koji Tamakoshi, Hiroshi Yatsuya

Geriatrics &amp; Gerontology International   Vol. 24 ( 7 ) page： 700 - 705   2024.7

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

Aim

Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long‐term cohort study in Japan.

Methods

We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age‐ and energy‐adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, &gt;135.86 g/day in men and 0 g/day, ≤126.44 g/day, &gt;126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis.

Results

The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P &lt; 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44).

Conclusions

In this study, milk intake in middle‐aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

DOI： 10.1111/ggi.14916

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定年退職期の就労継続と脳灰白質容積の10年間の変化

大塚 礼, 西田 裕紀子, 丹下 智香子, 八谷 寛, 久保田 彩, 安藤 富士子, 下方 浩史, 加藤 隆司, 中村 昭範, 荒井 秀典

日本老年医学会雑誌   Vol. 61 ( Suppl. ) page： 141 - 141   2024.5

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20歳から老年期にかけての体重変動はフレイル発症関連要因である 愛知職域コホート研究

洪 英在, 大塚 礼, 宋 澤安, 福田 知里, 小林 芽生, 松永 眞章, 太田 充彦, 李 媛英, 玉腰 浩司, 八谷 寛

日本老年医学会雑誌   Vol. 61 ( Suppl. ) page： 133 - 133   2024.5

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Relationship between size of pharyngeal and palatine tonsils and apnea–hypopnea index in pediatric obstructive sleep apnea Reviewed

Kaneko Masamichi, Hirata Masatoshi, Kimura Ayami, Inada Hiroya, Shikano Kazuki, Ito Satoshi, Okano Takayuki, Yatsuya Hiroshi, Nakata Seiichi

Fujita Medical Journal   Vol. 10 ( 2 ) page： 60 - 63   2024.5

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Language：English   Publisher：Fujita Medical Society  

<p><b>Objective: </b>To determine whether the combination of the pharyngeal tonsil grade and palatine tonsil grade results in differences in the apnea–hypopnea index (AHI) and to determine whether each parameter separately (pharyngeal tonsil grade and palatine tonsil grade) results in differences in severe obstructive sleep apnea (OSA).</p><p><b>Methods: </b>This cross-sectional study involved 107 children (mean age, 7.2 years; range, 4–12 years) suspected of having OSA because of snoring or sleep-related complaints. The patients underwent polysomnography, and their palatine and pharyngeal tonsils were graded.</p><p><b>Results: </b>In examining whether the palatine tonsils and pharyngeal tonsils could be risk factors for severe OSA, the adjusted odds ratios were 4.42 for palatine tonsil grade 4 versus 1–3 and 10.40 for pharyngeal tonsil grade 4 versus 1–3; both were highly statistically significant. We also found that the AHI when both the pharyngeal and palatine tonsils were grade 4 was higher than the AHI expected for the pharyngeal and palatine tonsils alone.</p><p><b>Conclusions: </b>The combination of grade 4 pharyngeal tonsils and grade 4 palatine tonsils resulted in an AHI much higher than the AHI of other combinations (pharyngeal tonsils grades 1–3 and 4, palatine tonsils grades 1–3 and 4). We believe that grade 4 pharyngeal tonsils and grade 4 palatine tonsils have a great influence on severe OSA and that grade 4 pharyngeal tonsils increase the AHI.</p>

DOI： 10.20407/fmj.2023-011

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日本人中年男性における長期的な収縮期血圧変動とうつ状態発症との関連

小林 芽生, 李 媛英, 宋 澤安, 洪 英在, 日比野 瑞歩, 田島 里菜, 太田 充彦, 大塚 礼, 玉腰 浩司, 八谷 寛

日本循環器病予防学会誌   Vol. 59 ( 2 ) page： 127 - 127   2024.4

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Factors influencing interprofessional collaboration in long-term care from a multidisciplinary perspective: a case study approach. Reviewed

Yoshida Y, Hirakawa Y, Hong YJ, Mamun MR, Shimizu H, Nakano Y, Yatsuya H

Home health care services quarterly     page： 1 - 20   2024.3

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Systematic assessments of interprofessional collaboration barriers and enablers in long-term care settings are critical for delivering person-centered healthcare. However, research on factors influencing interprofessional collaboration in long-term care settings is limited. For this study, 65 healthcare professionals across multiple facilities experienced in long-term care in Japan participated in online focus group discussions and individual interviews to discuss cases. The qualitative data were analyzed using qualitative content analysis. Seven themes emerged: coordination, the need for care manager training, hierarchy among healthcare professionals, specialization but not the mind-set of overspecialization, casual conversations, electronic group communication tools, and excessive fear of personal information protection. These findings highlight the need to develop coordinator roles and for interprofessional education on the proper approach to personal information protection laws. Furthermore, daily casual conversations, the use of online platforms, and the prevention of patients being left behind due to overspecialization are required.

DOI： 10.1080/01621424.2024.2331452

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新型コロナウイルス流行期の超過死亡と関連要因に関する主張への懸念 Reviewed

鈴木 貞夫, 尾島 俊之, 永田 知里, 八谷 寛, 若井 建志

東海公衆衛生雑誌   Vol. 11 ( 2 ) page： 143 - 144   2024.3

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DOI： 10.24802/tpha.2023-11

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Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers’ cohort study Reviewed International coauthorship

Abubakr Ahmed Abdullah Al-shoaibi, Yuanying Li, Zean Song, Young Jae Hong, Chifa Chiang, Yoshihisa Nakano, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

Obesity Research &amp; Clinical Practice   Vol. 18 ( 2 ) page： 101 - 108   2024.3

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.orcp.2024.02.006

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Prediction model of the risk for lateral local recurrence in locally advanced rectal cancer without enlarged lateral lymph nodes: Lessons from a Japanese multicenter pooled analysis of 812 patients Reviewed

Ogura, A; Shiomi, A; Yamamoto, S; Komori, K; Hamamoto, H; Manabe, S; Miyakita, H; Okuda, J; Yatsuya, H; Uehara, K

ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 8 ( 2 ) page： 284 - 292   2024.3

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Language：English   Publisher：Annals of Gastroenterological Surgery  

Aim: Although the oncological impact of lateral lymph node dissection on enlarged lateral lymph nodes has been gradually accepted over the last decade, that on lateral lymph nodes without swelling remains doubtful. This study aimed to develop a prediction model for the future risk of lateral local recurrence and to clarify the value of adding lateral lymph node dissection in locally advanced rectal cancer without enlarged lateral lymph nodes. Methods: This retrospective, multi-institutional study recruited 812 patients with cStage II/III low rectal cancer without enlarged lateral lymph nodes <7 mm. Total lateral local recurrence was a hypothetical value of future risk of lateral local recurrence when lateral lymph node dissection was never performed. Results: Overall, total lateral local recurrences were observed in 67 patients (8.3%). In the multivariate analyses, the strongest risk factor for total local recurrences was no preoperative chemoradiotherapy (odds ratio [OR][95%Cl]: 33.2 [4.56–241.7], P < 0.001), followed by tumor distance ≤40 mm (OR [95%Cl]: 2.71 [1.51–4.86], P < 0.001) and lateral lymph node 5–7 mm (OR[95%Cl]: 2.38 [1.26–4.48], P = 0.007). In patients with lateral lymph nodes of 5–7 mm, the total lateral recurrence rate was 4.8% after preoperative chemoradiotherapy. Lateral lymph node dissection could reduce from a total lateral local recurrence of 21.6% to an actual lateral local recurrence of 8.0% in patients without preoperative treatment. Conclusion: We introduce a novel prediction model of future risk of lateral local recurrences, which has the potential to enable us to indicate lateral lymph node dissection selectively according to the patients' risks.

DOI： 10.1002/ags3.12742

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Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis Reviewed

Masaaki Matsunaga, Yupeng He, May Thet Khine, Xuliang Shi, Ryusei Okegawa, Yuanying Li, Hiroshi Yatsuya, Atsuhiko Ota

Journal of Cancer Survivorship     2024.2

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

DOI： 10.1007/s11764-024-01557-8

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Other Link： https://link.springer.com/article/10.1007/s11764-024-01557-8/fulltext.html

The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. Reviewed International journal

Hanson Gabriel Nuamah, Yuanying Li, Hiroshi Yatsuya, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 33 ( 2 ) page： 107486 - 107486   2024.2

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: The associations between body mass index (BMI) and stroke subtypes, particularly intracerebral hemorrhage, have not been consistent. Such inconsistencies may be due to differences in the age at which BMI was obtained. We examined the possible age modifications in the association between BMI and stroke risk. MATERIALS AND METHODS: We followed 88,754 participants, aged 40-69 years at baseline (1990-1994), of the Japan Public Health Center-based prospective (JPHC) study for stroke incidence. BMI was obtained using self-reported body weight and height, which were categorized using the following cut-off points: 18.5, 21, 23, 25, 27.5, and 30 kg/m2. Time-dependent Cox proportional hazards models that updated BMI and covariates using 5- and 10-year questionnaire responses were used to estimate hazard ratios and 95 % confidence intervals. The analyses were stratified by age group (40-59 and ≥60 years) and the age of the individuals was updated. RESULTS: During the median follow-up period of 19 years, we documented 4,690 strokes, including 2,781 ischemic strokes and 1,358 intracerebral hemorrhages. After adjusting for sex, age, smoking, alcohol consumption, leisure-time physical activity, history of hypertension, dyslipidemia, and diabetes mellitus, we observed a positive linear association between BMI and ischemic stroke (linear trend, p < 0.001) in both age groups (interaction p>0.05). In contrast, a curvilinear association between BMI and intracerebral hemorrhage was observed in both the middle (curvilinear trend, p=0.017) and the older group (curvilinear trend, p=0.098) (interaction p>0.05). CONCLUSION: BMI and stroke associations did not vary significantly with age, although the association may differ according to subtype.

DOI： 10.1016/j.jstrokecerebrovasdis.2023.107486

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Anti-Factor Xa Activity in Patients With Chronic Thromboembolic Pulmonary Disease With or Without Pulmonary Hypertension Treated With Factor Xa Inhibitors

Nakano, Y; Adachi, S; Kondo, H; Hirose, M; Adachi, T; Nishiyama, I; Yasuda, K; Yoshida, M; Yatsuya, H; Murohara, T

CIRCULATION   Vol. 148   2023.11

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Language：English  

DOI： 10.1161/circ.148.suppl_1.13192Circulation

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肥満疫学研究の最前線 高齢期の身体指標の加齢変化と要介護予防

大塚 礼, 八谷 寛

肥満研究   Vol. 29 ( 合同学術集会抄録集 ) page： 131 - 131   2023.11

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Language：Japanese   Publishing type：Research paper (conference, symposium, etc.)   Publisher：(一社)日本肥満学会  

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