Faculty Profiles - YATSUYA Hiroshi

CiNii Research

Body mass index and activities of daily living impairment: systematic review and meta-analysis. Reviewed International coauthorship Open Access

Mamun MR, Nuamah HG, Hong YJ, Song Z, Akter T, Yoshida Y, Nakano Y, Saif-Ur-Rahman KM, Yatsuya H, Otsuka R

European journal of clinical nutrition 2026.2

Language：English Publishing type：Research paper (scientific journal) Publisher：European Journal of Clinical Nutrition

Both underweight and obesity have been linked to increased risk of disability, yet evidence on the relationship between body mass index (BMI) and activities of daily living (ADL) impairment remains inconsistent. To examine these associations in adults, we conducted this systematic review and meta-analysis following the standard methods and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Six databases were searched from inception to August 12, 2024. The protocol is registered in the PROSPERO (CRD42022357046). Abstracts and full-text articles describing associations between BMI and ADL impairment were screened using Rayyan software. Study quality was assessed using the RoBANS tool. A random-effects model meta-analysis was performed using metaanalysisonline, a web-based meta-analytic platform, with BMI categories of <18.5 (underweight), 25–29.9 (overweight), and ≥30 (obese) as exposures, and 18.5–24.9 (normal) as the reference. Of the initial 25,212 articles identified, 132 studies met the inclusion criteria. The meta-analysis showed positive association in both longitudinal studies [odds ratio (OR) 1.77, 95% confidence interval (CI): 1.54–2.03] and cross-sectional studies (OR: 1.56, 95% CI: 1.38–1.76). Overweight individuals exhibited a moderate increase in ADL risk in longitudinal studies (OR: 1.19, 95% CI: 1.09–1.30), but not in cross-sectional studies (OR: 1.06, 95% CI: 0.95–1.18). Both longitudinal and cross-sectional studies revealed a positive association between underweight participants and ADL impairment (OR: 1.20, 95% CI: 1.02–1.42; OR: 1.46, 95% CI: 1.24–1.72, respectively). Individuals with higher BMI, as well as those who are underweight, are at increased risk of ADL limitations.

DOI： 10.1038/s41430-026-01707-4

Open Access

Multidimensional fatigue profiles, workplace factors, and work-related outcomes in long-term cancer survivors: findings from the Aichi workers' cohort study Reviewed

Impact of normoglycaemia and prediabetes definitions on the estimated benefits of regression from prediabetes to normoglycaemia for type 2 diabetes risk. Reply to Choi W [Letter] Reviewed International coauthorship

Davoodian, N; Lotfaliany, M; Huxley, RR; Lee, CMY; Pasco, JA; Adams, RJ; Azizi, F; Bertoni, AG; Colagiuri, S; Gregg, EW; Gill, TK; Hadaegh, F; Khalili, D; Magliano, DJ; Mongraw-Chaffin, M; Mishra, GD; Shaw, JE; Sakurai, M; Yatsuya, H; Mohebbi, M

DIABETOLOGIA Vol. 69 ( 2 ) page： 531 - 532 2026.2

Association of Work-Related Stressors, Support and Satisfaction with Cardiovascular Disease Incidence Among Japanese Civil Servants: A Prospective Cohort Study. Reviewed Open Access

Song Z, Takada M, Wang S, Nishio N, Shi X, Kobayashi M, Matsunaga M, Hosaka Y, Ota A, Otsuka R, Tamakoshi K, Yatsuya H

Journal of occupational health 2026.1

Matsunaga, M; He, YP; Song, Z; Takada, M; Yatsuya, H; Ota, A

JOURNAL OF CANCER SURVIVORSHIP 2026.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Cancer Survivorship

Purpose: This study aimed to (1) identify distinct multidimensional fatigue profiles among employed cancer survivors, (2) examine associations between workplace factors and these profiles, and (3) assess how these profiles are associated with occupational outcomes. Methods: Seventy-two employed cancer survivors aged 27 to 64 years (median 9.4 years since diagnosis) from a local government in Japan completed questionnaires in 2023 assessing cancer-related fatigue (Cancer Fatigue Scale), workplace factors (job demands, job control, workplace support), and occupational outcomes (work engagement, presenteeism, cognitive function at work, and quality of life). Fatigue profiles were identified using hierarchical cluster analysis. Associations between workplace factors and profiles were examined using multinomial logistic regression. Occupational outcome differences among profiles were examined using linear regression. Results: Three profiles were identified: Low Global Fatigue (n = 12), Dominant Mental Fatigue (n = 36), and High Global Fatigue (n = 24). Workplace support—particularly supervisor understanding, colleague understanding, and schedule flexibility—was associated with approximately 75% lower odds of belonging to the High Global Fatigue group. Job demands and job control showed no associations. The High Global Fatigue group reported lower work engagement, higher presenteeism, reduced cognitive function at work, and poorer quality of life compared to the other groups. Conclusions: Three multidimensional fatigue profiles were identified among employed cancer survivors. Workplace support factors were more strongly associated with fatigue profiles than job characteristics. These profiles were associated with occupational outcomes. Implication for Cancer Survivors: These distinct fatigue profiles can guide personalized workplace interventions to optimize support for employed cancer survivors.

DOI： 10.1007/s11764-026-01975-w

Association of Adipose Tissue Insulin Resistance With Risk of Diabetes Incidence in Middle-aged Japanese Workers According to BMI States: 17 Years of Follow-up of the Aichi Worker’s Cohort Study Reviewed Open Access

Psychological distress and mental health service use trends in Japan (2013-2022): Focusing on the change before and after the COVID-19 pandemic Reviewed Open Access

Sasaki, N; Takae, A; Asaoka, H; Kuroda, N; Yatsuya, H; Nishio, N; Tabuchi, T; Nishi, D

JOURNAL OF AFFECTIVE DISORDERS Vol. 393 ( Pt A ) page： 120398 2026.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Affective Disorders

This study investigated trends in psychological distress and mental health service use in Japan before and after the COVID-19 pandemic using nationally representative data from the Comprehensive Survey of Living Conditions (2013–2022). Psychological distress was assessed using the Japanese version of the Kessler 6 Scale, with scores of 5–12 indicating moderate distress and scores of ≥13 indicating high distress. Mental health service use was defined as regular visits to hospitals or clinics for depression or other psychological disorders. Analysis of data from 1,765,102 participants revealed that while the prevalence of moderate distress decreased from 24.9 % in 2019 to 21.8 % in 2022, the prevalence of high distress increased from 4.7 % to 5.0 % over the same period. Notably, increases in high distress were most prominent among aged 35–49 population. Cross-sectionally, women aged 26–34 showed highest prevalence of high distress (7.6 %). Additionally, mental health service use rose markedly, especially among young adults with high distress, with women consistently reporting higher distress and service utilization than men. These findings suggest a polarization in psychological distress in Japan, with a decline in moderate symptoms concurrent with a rise in severe distress, highlighting emerging gaps in mental health care. The results underscore the need for targeted interventions and the expansion of accessible, diverse mental health services to address unmet needs, particularly among vulnerable subgroups including young women and middle-aged population.

DOI： 10.1016/j.jad.2025.120398

Regression from prediabetes to normoglycaemia and the role of cardiometabolic risk factors on the subsequent risk of developing type 2 diabetes Reviewed International coauthorship Open Access

DIABETOLOGIA Vol. 69 ( 1 ) page： 69 - 80 2026.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Diabetologia

Aims/hypothesis: We aimed to investigate the association between reversion to normoglycaemia among individuals with prediabetes (fasting plasma glucose 5.6–6.9 mmol/l in the absence of other criteria for type 2 diabetes) and the subsequent risk of type 2 diabetes, and to examine whether concurrent favourable cardiometabolic risk factor profiles modify this association. Methods: We used individual-level data from prospective cohorts in the USA, Australia and Asia. Participants with prediabetes at baseline, with at least two follow-ups (n=8191) at median intervals of 2.9 years (IQR 2.3–9.0) and 3.1 years (IQR 2.6–3.6), were classified into restoration of normoglycaemia and persistent prediabetes groups based on the glucose status at the first follow-up (normoglycaemia or prediabetes). Type 2 diabetes occurrence was assessed at subsequent follow-ups. Hierarchical mixed-effects proportional hazards Weibull models estimated type 2 diabetes risk, adjusting for age, sex and cardiometabolic risk factors. A subgroup analysis evaluated the combined association of normoglycaemia restoration and normal cardiometabolic risk factor levels on subsequent type 2 diabetes risk. Results: In individuals with prediabetes, normoglycaemia restoration compared with persistent prediabetes was associated with a 51% lower risk of developing type 2 diabetes. Even lower risks were observed among individuals with concurrent favourable cardiometabolic profiles, including non-smokers (HR 0.20, 95% CI 0.10, 0.31), and those with normal BMI (0.16, 95% CI 0.06, 0.27), waist circumference (0.22, 95% CI 0.12, 0.33), waist-to-height ratio (0.15, 95% CI 0.03, 0.26), WHR (0.17, 95% CI 0.05, 0.28), and systolic (0.20, 95% CI 0.11, 0.30) and diastolic (0.25, 95% CI 0.12, 0.38) blood pressure, triacylglycerol (0.24, 95% CI 0.13, 0.35) and HDL-cholesterol levels (0.21, 95% CI 0.13, 0.29). Weight loss combined with normoglycaemia restoration was also associated with lower type 2 diabetes risk (0.18, 95% CI 0.07, 0.30) compared with weight gain and persistent prediabetes. Conclusions/interpretation: Our results suggest that prioritising normoglycaemia restoration during the prediabetes stage in clinical guidelines may contribute to reducing the risk of type 2 diabetes, particularly when accompanied by favourable cardiometabolic health profiles.

DOI： 10.1007/s00125-025-06555-8

Akter Tahmina, Song Zean, Takada Midori, Hamrah Mohammad Hassan, Wang Shuang, Endale Baruck Tegegn, Paththamesthrige Shalini Enon Perera, Khine May Thet, Matsunaga Masaaki, Ota Atsuhiko, Tamakoshi Koji, Yatsuya Hiroshi

Journal of Epidemiology Vol. 36 ( 1 ) page： 44 - 50 2026.1

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: Insulin resistance in adipocytes, manifested as high basal circulating free fatty acid (FFA) is thought to contribute to the development of type 2 diabetes mellitus (T2DM). However, the association between adipocyte insulin resistance (Adipo-IR) index and T2DM has rarely been explored in prospective studies. We examined this association in a middle-aged Japanese workers’ cohort. Since the association may differ according to the degree of overall adiposity, the analysis was stratified by the presence of overweight/obesity defined with body mass index (BMI).Methods: A total of 3,257 subjects (men 2501, women 756) aged 35–66 years were followed-up for up to 17 years. T2DM incidence was defined as fasting blood glucose level ≥126 mg/dL, glycated hemoglobin level ≥6.5%, or self-reported initiation of glucose-lowering medications. Adipo-IR was calculated as the product of FFA (mmol/L) and insulin (pmol/L) obtained from baseline fasting blood samples and divided into sex- and BMI category (<25 or ≥25 kg/m2)-specific tertiles. Cox-proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for age, BMI, smoking status, physical activity, drinking habit, and family history of diabetes.Results: During a median of 14.6 years of follow-up, 365 developed T2DM. Compared with the lowest tertile, T2DM risk was significantly increased among the highest tertile category in overweight/obese men (HR 2.94; 95% CI, 1.76–4.90) and women (HR 4.24; 95% CI, 1.08–16.61).Conclusion: Adipo-IR was positively associated with T2DM risk in overweight/obese men and women.

DOI： 10.2188/jea.JE20250025

The association between chronotype and metabolic syndrome in middle-aged Japanese civil servants: A longitudinal study from Aichi Workers' Cohort Reviewed

Endale, BT; Song, Z; Takada, M; Paththamesthrige, SEP; Matsunaga, M; Kitajima, T; Ota, A; Tamakoshi, K; Yatsuya, H

CHRONOBIOLOGY INTERNATIONAL page： 1 - 12 2025.12

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Chronobiology International

Chronotype, which reflects an individual’s preference for activity and sleep timing, has been associated with various chronic conditions, particularly the evening chronotype. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that collectively increase the risk of developing type 2 diabetes mellitus and cardiovascular diseases. Previous studies on chronotype and MetS have been inconsistent, and none has explored the longitudinal association between MetS and its components. Therefore, this study investigated these associations in middle-aged Japanese civil servants. We analyzed 2231 non-rotating, non-night shift workers (aged 29–69, 71.6% male) from the Aichi Workers’ Cohort Study who participated in surveys in 2018 (baseline) and 2022 and were free of MetS at baseline. Participants were classified into morning, evening, or intermediate chronotypes using the shortened Morningness–Eveningness Questionnaire. MetS was defined according to the harmonized criteria for Japanese, based on waist circumference (≥85 cm for men and ≥90 cm for women), triglycerides, HDL cholesterol, blood pressure, and blood sugar levels. Over 4 y, 232 participants (10.4%) developed MetS, with a cumulative incidence rate of 9.9% in morning, 17.6% in evening, and 9.5% in intermediate types. Logistic regression analysis adjusted for sex, age, educational background, occupation, leisure-time physical activity, alcohol intake, sleep duration, smoking status, snoring, night-time awakening, sleep medication use, working hours, breakfast eating habit, and medication use for diabetes, hypertension, and dislipdemia, revealed that the evening type individuals had a significantly higher risk of MetS (OR: 2.30, 95% CI: 1.48–3.57) compared to intermediate types. In conclusion, evening chronotype was independently associated with a higher risk of developing MetS in middle-aged Japanese civil servants.

DOI： 10.1080/07420528.2025.2606278

Association between occupational stress responses and cardiovascular disease incidence in middle-aged Japanese: findings from the Aichi workers' cohort study Reviewed

Song, Z; Takada, M; Hong, YJ; Endale, BT; Nishio, N; Horikoshi, M; Khine, MT; Matsunaga, M; He, YP; Ota, A; Otsuka, R; Tamakoshi, K; Yatsuya, H

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH Vol. 99 ( 1 ) page： 3 2025.12

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：International Archives of Occupational and Environmental Health

Objectives: This study aimed to investigate the association between occupational stress responses indicated by fatigue and nonspecific physical complaints and the incidence of subsequent cardiovascular disease (CVD) in middle-aged Japanese workers. Methods: A cohort of 4,820 Japanese workers (3876 men and 944 women) aged 35–65 years was followed up from 2007 to March 2022 for CVD incidence. Fatigue and nonspecific physical complaints were evaluated using the 57-item Brief Job Stress Questionnaire, and each was categorized into two groups based on the presence or absence. Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) for stress responses to CVD were estimated using a multivariable Cox proportional hazard model adjusted for age, sex, smoking status, alcohol consumption, regular exercise, sleep duration, working hours, body mass index, systolic blood pressure, total cholesterol, and histories of hypertension, hyperlipidemia, and diabetes, night shift and job type. Results: During the median follow-up of 13.7 years, 116 patients with CVD were identified. The presence of fatigue was independently associated with CVD incidence (HR: 2.28, 95% CI: 1.05–4.94). Similarly, the presence of nonspecific physical complaints was significantly associated with CVD incidence (HR: 2.54, 95% CI: 1.43–4.52). The sex-stratified analysis showed consistent results in men but not in women. Conclusions: These findings suggest that fatigue and nonspecific physical complaints may serve as early indicators of CVD risk among middle-aged Japanese male workers. Incorporating routine assessment of these stress responses into workplace health screening could facilitate targeted prevention strategies.

DOI： 10.1007/s00420-025-02189-w

Application of the third-generation cognitive and behavioral therapies (e.g. ACT and mindfulness) in occupational health Open Access

Association between eveningness and low back pain among public servants in Japan: a cross-sectional analysis of the Aichi Workers' Cohort Study Reviewed Open Access

Matsunaga, M; Okegawa, R; Fujita, N; Kitajima, T; Yatsuya, H; Ota, A

EUROPEAN SPINE JOURNAL Vol. 34 ( 12 ) page： 5424 - 5430 2025.12

Language：English Publishing type：Research paper (scientific journal) Publisher：European Spine Journal

Purpose: Low back pain (LBP) is a common occupational health problem. Chronotype, an individual’s preferred timing of activity and sleep, has been linked to pain perception. Previous studies have found a potential association between chronotype and LBP, although the findings were limited by small sample sizes and restricted population types. We investigated the association between evening chronotype (eveningness) and LBP in a cohort comprising public servants of various ages. Methods: We conducted a cross-sectional analysis of 4728 full-time public servants in Japan. LBP was assessed using a self-reported question. Individuals’ chronotypes were determined using the reduced Morningness–Eveningness Questionnaire. The association between chronotype and LBP was analyzed using the chi-squared test and multiple logistic regression models adjusted for age, sex, occupation, overtime work, use of the internet/email, body mass index, smoking status, exercise habits, sedentary behavior, sleep duration, sleep medication use, and depressive symptoms. Results: In total, 30% of the subjects reported LBP. The most common chronotype was intermediate type (51%), followed by morningness (38%) and eveningness (11%). A significant association between eveningness and LBP was observed. After adjusting for potential confounders, individuals with eveningness had a higher prevalence of LBP than those with morningness (36.2% vs. 28.7%; odds ratio: 1.46; 95% confidence interval: 1.16–1.83). Conclusion: Eveningness was statistically associated with LBP in a cohort of public servants. The present findings would strengthen the association’s generalizability to more varied populations.

DOI： 10.1007/s00586-025-09048-9

NARISADA Akihiko, TAKASAKI Masako, MIZUGUCHI Yohei, YATSUYA Hiroshi

Job Stress Research Vol. 32 ( 4 ) page： 347 - 352 2025.11

Relationship between abdominal visceral adipose tissue and cardiovascular events in patients with acute coronary syndrome Reviewed Open Access

Ueyama, C; Horibe, H; Maekawa, Y; Hiramatsu, S; Yamase, Y; Funabiki, J; Takemoto, Y; Shigeta, T; Hibino, T; Kondo, T; Yatsuya, H; Ishii, H; Murohara, T

HEART AND VESSELS Vol. 40 ( 11 ) page： 961 - 972 2025.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Heart and Vessels

Abdominal visceral adipose tissue (AVAT) is associated with the incidence of cardiovascular events (CVEs). We retrospectively evaluated the association between AVAT and the incidence of CVEs in 602 patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Patients were divided into four groups according to the quartiles of AVAT areas using computed tomography. The incidence of CVEs (cardiovascular death, ACS recurrence and stroke) during the follow-up period (median 49.5 months) was evaluated. Cox analysis adjusting for cardiovascular risk factors revealed that the AVAT quartile classification exhibited a significant association with the incidence of CVEs. The risk in quartile 3 (moderate AVAT areas, ≥ 106.0 to < 142.6 cm2) was significantly lower than in quartiles 1 (low AVAT areas, < 71.0cm2; P < 0.01; hazard ratio [HR], 5.06), 2 (mild AVAT areas, ≥ 71.0 to < 106.0 cm2; P < 0.01; HR, 4.25) and 4 (severe AVAT areas, ≥ 142.6 cm2; P < 0.01; HR, 4.52). Polynomial analyses revealed that quadratic model was the most appropriate to illustrate the relationship between AVAT area and the hazard ratios for CVEs (corrected Akaike's information criterion, 49.2; R2, 0.47). The AVAT area and the incidence of CVEs exhibited a U-shaped relationship in patients with ACS undergoing PCI independent of conventional cardiovascular risk factors. The risk of CVEs was the lowest in patients with moderate AVAT areas. Evaluating AVAT may provide additional information for the assessment of long-term prognosis in patients with ACS.

DOI： 10.1007/s00380-025-02557-z

Analysis of the changes in health-related quality of life and employment status after surgery in patients with lung cancer: a single-center longitudinal study Reviewed Open Access

Yuka Kadomatsu, Toru Oga, Atsuhiko Ota, Hiroshi Yatsuya, Yuta Kawasumi, Harushi Ueno, Taketo Kato, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

General Thoracic and Cardiovascular Surgery Vol. 73 ( 11 ) page： 819 - 828 2025.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Objective

This study analyzed the changes in health-related quality of life (HRQOL) and employment status of patients undergoing lung cancer surgery in Japan.

Methods

This was a single-center, prospective study on patients who underwent lung anatomical resection. The eligible patients completed self-reported HRQOL and employment surveys at baseline and 6 and 12 months postoperatively. HRQOL was assessed using questionnaires including the European Organization for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC QLQ and Lung Cancer module and additional social engagement and work-related stress evaluation tools.

Results

In total, 93 patients completed the baseline survey, and 80 provided survey data at 6 months postoperatively. The HRQOL scores of several factors significantly declined immediately after the surgery and then gradually improved. The EORTC global health score, which represents overall health status, returned to baseline levels at 12 months postoperatively. However, symptoms such as fatigue, dyspnea, and coughing did not return to baseline levels at 12 months postoperatively. Approximately 68% of the patients who were employed preoperatively continued to work at 12 months postoperatively.

Conclusions

Lung cancer surgery significantly affected the HRQOL and employment status of the patients within the first 6 months after surgery. For patients who decide to return to work before full recovery of QOL, we consider the need for enhanced support to assist them as they can reintegrate into work and activities of daily living.

DOI： 10.1007/s11748-025-02144-z

Other Link： https://link.springer.com/article/10.1007/s11748-025-02144-z/fulltext.html

Otsuka, R; Zhang, S; Nishita, Y; Kubota, S; Tange, C; Shimokata, H; Yatsuya, H

ARCHIVES OF GERONTOLOGY AND GERIATRICS Vol. 137 page： 105943 2025.10

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Archives of Gerontology and Geriatrics

Objective: To quantify annual changes and develop population-normalized aging curves for height, body weight, and grip strength according to specific birth cohorts. Methods: This longitudinal study analyzed data from the National Institute for Longevity Sciences – Longitudinal Study of Aging, following 1901 community-dwelling adults aged 40−79 years for up to 12 years. Annual changes in height, body weight, body mass index (BMI), body fat percentage, skeletal muscle mass, and grip strength were assessed by sex using linear mixed-effects models. Birth cohort-specific reference values according to sex were developed using participants who participated in at least one wave between 1997 and 2022 (n = 1990) with generalized additive mixed models. Results: Significant negative follow-up years × age interactions were observed for height, body weight, BMI, skeletal muscle mass, and grip strength in men (all p-values < 0.001) and for height, body weight, BMI, body fat percentage, and skeletal muscle mass in women (all p-values < 0.01). Grip strength began declining preceding any significant change in other indicators. For height and grip strength, birth cohort-specific reference values for age-related changes showed a gradual decline with age in both sexes, with more recent birth cohorts being consistently taller but having weaker grip strength than earlier cohorts. Men experienced slight weight increases until ages 60−70 years, followed by a decline. Women maintained a stable weight until age 60 years before declining. Conclusions: These reference values provide evidence-based tools for detecting age-related changes in body composition and function among relatively healthy participants and guiding preventive interventions in clinical and community settings.

DOI： 10.1016/j.archger.2025.105943

Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies Reviewed International coauthorship Open Access

Davoodian, N; Lotfaliany, M; Huxley, RR; Lee, CMY; Pasco, JA; Adams, RJ; Azizi, F; Bertoni, AG; Björkelund, C; Colagiuri, S; Fahimfar, N; Gabriel, R; Giedraitis, V; Gill, TK; González, C; Gregg, EW; Hadaegh, F; Hange, D; Harland, JW; Hodge, AM; Holloway-Kew, KL; Hosseini, SR; Jacobs, DR ; Khalili, D; Magliano, DJ; Mongraw-Chaffin, M; Mishra, G; Lissner, L; Mehlig, K; Najafipour, H; Nieto-Martinez, R; Ostovar, A; Shadkam, M; Shaw, JE; Sundh, V; Schreiner, PJ; Sakurai, M; Wittert, GA; Yatsuya, H; Zethelius, B; Mohebbi, M

LANCET GLOBAL HEALTH Vol. 13 ( 9 ) 2025.9

Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis Reviewed

Masaaki Matsunaga, Yupeng He, May Thet Khine, Xuliang Shi, Ryusei Okegawa, Yuanying Li, Hiroshi Yatsuya, Atsuhiko Ota

Journal of Cancer Survivorship Vol. 19 ( 4 ) page： 1346 - 1356 2025.8

Psychiatric and psychological adverse effects associated with dulaglutide, semaglutide, and liraglutide: A vigibase study Reviewed International coauthorship Open Access

Nishida, K; Chrétien, B; Dolladille, C; Ebina, T; Aleksic, B; Cabé, N; Savey, V; Onoue, T; Yatsuya, H

CLINICAL NUTRITION Vol. 51 page： 252 - 265 2025.8

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical Nutrition

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are crucial in managing type 2 diabetes mellitus (T2DM) and obesity. Agents like dulaglutide, semaglutide, and liraglutide mimic endogenous GLP-1, enhancing insulin secretion and promoting satiety. Beyond glycemic control, they offer cardioprotective and neuroprotective benefits. However, concerns about psychiatric adverse effects have emerged, necessitating a systematic assessment of their safety profile. Material & Methods: This multinational pharmacovigilance study utilized VigiBase® data up to December 1, 2024, focusing on adverse drug reaction (ADR) reports for GLP-1 RAs. Psychiatric ADRs were classified using MedDRA terminology. Disproportionality analyses were conducted via logistic regression to calculate reporting adjusted Reporting Odds Ratios (aRORs) within reports involving antidiabetic or anti-obesity medications. A causal forest model assessed the individual treatment effect (ITE) of semaglutide on depression and suicidality reporting. Results: Among 2,061,901 reports, 21,414 involved psychiatric ADRs for GLP-1 RAs. Significant signals were observed for anxiety (aROR: 1.26, 95%CI: 1.18–1.35), depressed mood disorders (aROR: 1.70, 95%CI: 1.57–1.84) and suicidality (aROR 1.45, 95%CI: 1.29–1.63) with semaglutide, and eating disorders with all three GLP-1 RAs (aRORs between 4.17 and 6.80). The causal forest model estimated an average treatment effect of 0.0046 for semaglutide on depression and suicidality reporting, with significant heterogeneity across regions and demographic groups. Discussion: The study found no significant increase in overall psychiatric ADR reporting for GLP-1 RAs, except for eating disorders and depression/suicidality in semaglutide-treated patients. Sensitivity analyses before June 4, 2021, found no signals, aligning with RCT data. Post-marketing reports linked semaglutide to depression and suicidal ideation, prompting regulatory investigations. The causal forest model revealed significant heterogeneity in the psychiatric safety profile of semaglutide, with regional factors influencing ADR reporting. Conclusion: While GLP-1 RAs do not show a significant increase in overall psychiatric ADR reporting, findings suggest that clinicians should remain vigilant for potential depressive symptoms and suicidality, particularly in individuals with obesity treated with semaglutide since its approval for weight management.

DOI： 10.1016/j.clnu.2025.06.011

Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20-54 years: A three decades comparative study (1990-2021) using Global Burden of Disease study data Reviewed International coauthorship Open Access

Yang, DR; Fan, GH; Cheng, JJ; Meng, QZ; Liu, KY; Shirai, K; Yatsuya, H; Chen, R; Zhang, Y

TOBACCO INDUCED DISEASES Vol. 23 2025.8

A comparison of the diagnostic ability of 1-mm computed tomography and 3-mm magnetic resonance imaging for detecting lateral pelvic lymph node metastases from rectal cancer Reviewed

Kobayashi, R; Uehara, K; Ebata, T; Yatsuya, H; Li, YY; Hida, K; Hashiguchi, Y; Ishihara, S; Ogawa, S; Shiomi, A; Kawai, K; Ajioka, Y

SURGERY TODAY Vol. 55 ( 8 ) page： 1189 - 1197 2025.8

Language：English Publisher：Surgery Today

Aim: The best modality for evaluating lateral pelvic lymph node (LPLN) metastases from rectal cancer remains unclear. This study compared the diagnostic ability of 1-mm computed tomography (CT) and 3-mm magnetic resonance imaging (MRI) in identifying LPLN metastases based on size. Methods: This observational study analyzed not individual patients but 191 sides from 100 rectal cancer patients without preoperative treatment for whom preoperative CT and MRI and corresponding pathological results for LPLNs were available. A swollen LPLN was defined as an LN with a short-axis size of ≥5 mm on 1-mm CT. Results: LPLNs were detected significantly more frequently with 1-mm CT than with 3-mm MRI (p < 0.001). Among the 117 sides without swollen LPLNs, metastasis was observed in 1.7% of patients. In contrast, LPLN metastasis was confirmed in 28.4% of 74 sides with swollen LPLNs. In the evaluation of swollen LPLNs, 3-mm MRI yielded a 34% improvement in the diagnostic performance of LPLN metastasis over 1-mm CT (categorical net reclassification improvement: 0.341, p = 0.045). Conclusions: In conclusion, 1-mm CT should be performed preoperatively to evaluate LPLNs. Further evaluations can be omitted in the absence of swollen LPLNs. In patients with swollen LPLNs, a careful assessment of LPLN metastasis should be conducted via additional MRI, even in early T-stage tumors.

DOI： 10.1007/s00595-025-03018-w