Faculty Profiles - YATSUYA Hiroshi

Papers - YATSUYA Hiroshi

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Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up. Reviewed Open Access

Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

Journal of diabetes investigation Vol. 10 ( 3 ) page： 837 - 845 2019.5

Language：English Publishing type：Research paper (scientific journal)

AIMS/INTRODUCTION: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. METHODS: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. RESULTS: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. CONCLUSIONS: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

DOI： 10.1111/jdi.12930

Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II. Reviewed Open Access

Rie Hayashi, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

Circulation journal : official journal of the Japanese Circulation Society Vol. 83 ( 5 ) page： 1072 - 1079 2019.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). CONCLUSIONS: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

DOI： 10.1253/circj.CJ-18-0842

特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標愛知職域コホート

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 Vol. 61 ( 臨増 ) page： 321 - 321 2019.5

トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 八谷寛, 上島通浩

産業衛生学雑誌 Vol. 61 ( 臨増 ) page： 332 - 332 2019.5

Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review. Reviewed International journal Open Access

Ota A, Fujisawa A, Kawada K, Yatsuya H

International journal of environmental research and public health Vol. 16 ( 8 ) 2019.4

Language：English Publishing type：Research paper (scientific journal)

Cancer patients' return-to-work rates in Japan and their methodological quality have been little reported. We conducted a systematic review to explore the recent return-to-work rates and to assess the methodological quality of the existing literature. We selected 13 papers (2 in English and 11 in Japanese) published between 2005 and 2017. The return-to-work rates ranged from 53.8% to 95.2%. Of the selected papers, 12 papers employed a cross-sectional design, possessing high risk of selection bias due to participant selection. A total of 8 papers did not fully report the subjects' sex, age, employment status at cancer diagnosis, cancer site, stage, and treatment, suggesting high risk of selection bias due to confounding variables. High or unclear risk of attrition bias due to incomplete outcome data was detected in 12 papers in which data on return to work were not collected from all participants. High risk of reporting bias due to selective outcome reporting was pointed out in 6 studies in which the subjects' employment status at return to work or the duration between cancer diagnosis and assessment of return to work was unclear. Future studies must reduce the risk of selection, attrition, and reporting biases for specifying accurate return-to-work rates.

DOI： 10.3390/ijerph16081461

Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0). Reviewed International coauthorship Open Access

Khine MT, Ota A, Gearhardt AN, Fujisawa A, Morita M, Minagawa A, Li Y, Naito H, Yatsuya H

Nutrients Vol. 11 ( 3 ) page： 687 - 687 2019.3

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The Yale Food Addiction Scale 2.0 (YFAS 2.0) is used for assessing food addiction (FA). Our study aimed at validating its Japanese version (J-YFAS 2.0). The subjects included 731 undergraduate students. Confirmatory factor analysis indicated the root-mean-square error of approximation, comparative fit index, Tucker–Lewis index, and standardized root-mean-square residual were 0.065, 0.904, 0.880, and 0.048, respectively, for a one-factor structure model. Kuder–Richardson α was 0.78. Prevalence of the J-YFAS 2.0-diagnosed mild, moderate, and severe FA was 1.1%, 1.2%, and 1.0%, respectively. High uncontrolled eating and emotional eating scores of the 18-item Three-Factor Eating Questionnaire (TFEQ R-18) (p < 0.001), a high Kessler Psychological Distress Scale score (p < 0.001), frequent desire to overeat (p = 0.007), and frequent snacking (p = 0.003) were associated with the J-YFAS 2.0-diagnosed FA presence. The scores demonstrated significant correlations with the J-YFAS 2.0-diagnosed FA symptom count (p < 0.01). The highest attained body mass index was associated with the J-YFAS 2.0-diagnosed FA symptom count (p = 0.026). The TFEQ R-18 cognitive restraint score was associated with the J-YFAS 2.0-diagnosed FA presence (p < 0.05) and symptom count (p < 0.001), but not with the J-YFAS 2.0-diagnosed FA severity. Like the YFAS 2.0 in other languages, the J-YFAS 2.0 has a one-factor structure and adequate convergent validity and reliability.

DOI： 10.3390/nu11030687

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy. Reviewed International journal

Ohmiya N, Hotta N, Mitsufuji S, Nakamura M, Omori T, Maeda K, Okuda K, Yatsuya H, Tajiri H

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society Vol. 31 ( 2 ) page： 164 - 172 2019.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIM: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. METHODS: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. RESULTS: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. CONCLUSION: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.1111/den.13259

Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013. Reviewed International coauthorship Open Access

Cui M, Chiang C, Cui R, Honjo K, Yatsuya H, Watson BM, Ikerdeu E, Mita T, Madraisau S, Aoyama A, Iso H

Journal of epidemiology Vol. 29 ( 3 ) page： 97 - 103 2019.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. METHODS: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25-64 years. RESULTS: The age-adjusted mean BMI was 29.3 kg/m2 in men and 29.9 kg/m2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m2) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. CONCLUSION: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

DOI： 10.2188/jea.JE20170127

Sleep duration and risk of breast cancer: The JACC Study Reviewed

Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

BREAST CANCER RESEARCH AND TREATMENT Vol. 174 ( 1 ) page： 219 - 225 2019.2

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium Reviewed International coauthorship International journal Open Access

Inker L.A, Grams M.E, Levey A.S, Coresh J, Cirillo M, Collins J.F, Gansevoort R.T, Gutierrez O.M, Hamano T, Heine G.H, Ishikawa S, Jee S.H, Kronenberg F, Landray M.J, Miura K, Nadkarni G.N, Peralta C.A, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak M.G, Zhang L, van Zuilen A.D, Hallan S.I, Kovesdy C.P, Woodward M, Levin A, Astor B, Appel L, Greene T, Chen T, Chalmers J, Arima H, Perkovic V, Yatsuya H, Tamakoshi K, Li Y, Hirakawa Y, Matsushita K, Sang Y, Polkinghorne K, Chadban S, Atkins R, Djurdjev O, Liu L, Zhao M, Wang F, Wang J, Ebert N, Martus P, Tang M, Emrich I, Seiler S, Zawada A, Nally J, Navaneethan S, Schold J, Sarnak M, Katz R, Hiramoto J, Iso H, Yamagishi K, Umesawa M, Muraki I, Fukagawa M, Maruyama S, Hasegawa T, Fujii N, Wheeler D, Emberson J, Townend J, Brenner H, Sch{\"o}ttker B, Saum K.-U, Fox C, Hwang S.-J, K{\"o}ttgen A, Schneider M.P, Eckardt K.-U, Green J, Kirchner H.L, Chang A.R, Ho K, Ito S, Miyazaki M, Nakayama M, Yamada G, Irie F, Sairenchi T, Yano Y, Kotani K, Nakamura T, Kimm H, Mok Y, Chodick G, Shalev V, Wetzels J.F.M, Blankestijn P.J, van den Brand J, Kollerits B, Ritz E, Nitsch D, Roderick P, Fletcher A, Bottinger E, Ellis S.B, Nadukuru R, Ueshima H, Okayama A, Tanaka S, Okamura T, Kadota A, Kenealy T, Elley C.R, Drury P.L, Ohkubo T, Asayama K, Metoki H, Kikuya M, Nelson R.G, Knowler W.C, Bakker S.J, Hak E, Heerspink H.J.L, Brunskill N, Major R, Shepherd D, Medcalf J, Jassal S.K, Bergstrom J, Ix J.H, Barrett-Connor E, Kalantar-Zadeh K, Sumida K, Muntner P, Warnock D, McClellan W, de Zeeuw D, Brenner B, Ikram M.A, Hoorn E.J, Dehghan A, Carrero J.J, Gasparini A, Wettermark B, Elinder C.-G, Wong T.Y, Sabanayagam C, Cheng C.-Y, Visseren F.L.J, Evans M, Segelmark M, Stendahl M, Sch{\"o}n S, Tangri N, Sud M, Naimark D, Wen C.-P, Tsao C.-K, Tsai M.-K, Chen C.-H, Konta T, Hirayama A, Ichikawa K, Lannfelt L, Larsson A, A}rnl{\"o}v J, Bilo H.J.G, Landman G.W.D, van Hateren K.J.J, Kleefstra N, Coresh (Chair J, Hallan S, Ballew S.H, Chen J, Kwak L, Surapaneni A

American Journal of Kidney Diseases Vol. 73 ( 2 ) page： 206 - 217 2019.2

Language：English Publishing type：Research paper (scientific journal)

© 2018 National Kidney Foundation, Inc. Rationale & Objective: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design: Cross-sectional individual participant-level analyses in a global consortium. Setting & Study Populations: 17 CKD and 38 general population and high-risk cohorts. Selection Criteria for Studies: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. Data Extraction: Data were obtained and analyzed between July 2015 and January 2018. Analytical Approach: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. Results: The CKD cohorts (n = 254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n = 1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59 mL/min/1.73 m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30 mg/g). Limitations: Variations in study era, health care delivery system, typical diet, and laboratory assays. Conclusions: Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

DOI： 10.1053/j.ajkd.2018.08.013

Other Link： http://orcid.org/0000-0002-3283-8196

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium Reviewed International coauthorship Open Access

Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

BMJ-BRITISH MEDICAL JOURNAL Vol. 364 2019.1

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) Reviewed International journal Open Access

Satoh Michihiro, Ohkubo Takayoshi, Asayama Kei, Murakami Yoshitaka, Sugiyama Daisuke, Yamada Michiko, Saitoh Shigeyuki, Sakata Kiyomi, Irie Fujiko, Sairenchi Toshimi, Ishikawa Shizukiyo, Kiyama Masahiko, Ohnishi Hirofumi, Miura Katsuyuki, Imai Yutaka, Ueshima Hirotsugu, Okamura Tomonori, Iso Hiroyasu, Kitamura Akihiko, Ninomiya Toshiharu, Kiyohara Yutaka, Nakagawa Hideaki, Nakayama Takeo, Okayama Akira, Sairenchi Toshimi, Tamakoshi Akiko, Tsuji Ichiro, Miyamoto Yoshihiro, Ishikawa Shizukiyo, Yatsuya Hiroshi, Okamura Tomonori

HYPERTENSION Vol. 73 ( 1 ) page： 52 - 59 2019.1

Language：English Publishing type：Research paper (scientific journal)

Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. The present metaanalysis included 107 737 Japanese (42.4% men; mean age, 55.1 years) from 13 cohorts. During the mean follow-up of 15.2±5.3 years (1 559 136 person-years), 1922 died from stroke and 913 from CHD. We estimated risks after adjusting for competing risk of death other than the outcome of interest. The 10-year risk of stroke and CHD deaths at index age of 35 years was ≤1.9% and ≤0.3%, respectively. The LTRs of stroke death at the index age of 35 years (men/women) were 6.1%/4.8% for optimal, 5.7%/6.3% for normal, and 6.6%/6.0% for high-normal blood pressure groups, and 9.1%/7.9% for grade 1, 14.5%/10.3% for grade 2, and 14.6%/14.3% for grade 3 hypertension groups. The LTRs of CHD death similarly elevated with an increase in blood pressure but were lower (≤7.2%) than those of stroke death. In conclusion, blood pressure was clearly associated with an elevated LTR of stroke or CHD death, although the LTR of CHD death was one-half of that of stroke death in an Asian population. These results would help young people with hypertension to adopt a healthy lifestyle or start antihypertensive therapy early.

DOI： 10.1161/HYPERTENSIONAHA.118.11635

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Smoking results in accumulation of ectopic fat in the liver. Reviewed International journal

Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes, metabolic syndrome and obesity : targets and therapy Vol. 12 page： 1075 - 1079 2019

Language：English Publishing type：Research paper (scientific journal)

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

DOI： 10.2147/DMSO.S212495

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study Reviewed Open Access

Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS Vol. 26 ( 9 ) page： 775 - 782 2019

Smoking results in accumulation of ectopic fat in the liver. Reviewed

Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes Metab Syndr Obes Vol. 9 ( 12 ) page： 1075 - 1080 2019

MULTICENTER FEASIBILITY STUDY OF BOWEL PREPARATION WITH CASTOR OIL FOR COLON CAPSULE ENDOSCOPY Reviewed International journal

OHMIYA Naoki, HOTTA Naoki, MITSUFUJI Shoji, NAKAMURA Masanao, OMORI Takafumi, MAEDA Kohei, OKUDA Kotaro, YATSUYA Hiroshi, TAJIRI Hisao

GASTROENTEROLOGICAL ENDOSCOPY Vol. 61 ( 12 ) page： 2646 - 2655 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Gastroenterological Endoscopy Society

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster.Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged.Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P＜0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P=0.0048), male gender (adjusted OR, 3.20; P=0.0051), and use of castor oil (adjusted OR, 6.29; P=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively.Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.11280/gee.61.2646

Scopus

CiNii Research

Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. Reviewed International journal Open Access

Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A

Pediatric transplantation Vol. 22 ( 7 ) page： e13239 2018.11

Language：English Publishing type：Research paper (scientific journal)

Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P = .041), PELD (OR 1.091; P = .038), and biliary atresia (OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

DOI： 10.1111/petr.13239

Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study International coauthorship Open Access

Gebremariam Lemlem Weldegerima, Aoyama Atsuko, Kahsay Alemayehu Bayray, Hirakawa Yoshihisa, Chiang Chifa, Yatsuya Hiroshi, Matsuyama Akiko

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 451 - 464 2018.11

Language：English Publishing type：Research paper (scientific journal)

Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

DOI： 10.18999/nagjms.80.4.451

Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study International coauthorship Open Access

Al-Shoaibi Abubakr Ahmed Abdullah, Matsuyama Akiko, Khalequzzaman Md, Haseen Fariha, Choudhury Sohel Reza, Hoque Bilqis Amin, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi, Aoyama Atsuko

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 559 - 569 2018.11

Language：English Publishing type：Research paper (scientific journal)

The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

DOI： 10.18999/nagjms.80.4.559

HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH Reviewed International coauthorship

Choudhury Sohel, Al-Shoaibi Abubakr Ahmed Abdullah, Khalequzzaman Mohammad, Al Mamun Mohammad Abdullah, Chiang Chifa, Yatsuya Hiroshi, Aoyama Atsuko

JOURNAL OF HYPERTENSION Vol. 36 page： E337 - E338 2018.10

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