Faculty Profiles - YATSUYA Hiroshi

Psychiatric and psychological adverse effects associated with dulaglutide, semaglutide, and liraglutide: A vigibase study Open Access

Nishida, K; Chrétien, B; Dolladille, C; Ebina, T; Aleksic, B; Cabé, N; Savey, V; Onoue, T; Yatsuya, H

CLINICAL NUTRITION Vol. 51 page： 252 - 265 2025.8

Language：English Publisher：Clinical Nutrition

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are crucial in managing type 2 diabetes mellitus (T2DM) and obesity. Agents like dulaglutide, semaglutide, and liraglutide mimic endogenous GLP-1, enhancing insulin secretion and promoting satiety. Beyond glycemic control, they offer cardioprotective and neuroprotective benefits. However, concerns about psychiatric adverse effects have emerged, necessitating a systematic assessment of their safety profile. Material & Methods: This multinational pharmacovigilance study utilized VigiBase® data up to December 1, 2024, focusing on adverse drug reaction (ADR) reports for GLP-1 RAs. Psychiatric ADRs were classified using MedDRA terminology. Disproportionality analyses were conducted via logistic regression to calculate reporting adjusted Reporting Odds Ratios (aRORs) within reports involving antidiabetic or anti-obesity medications. A causal forest model assessed the individual treatment effect (ITE) of semaglutide on depression and suicidality reporting. Results: Among 2,061,901 reports, 21,414 involved psychiatric ADRs for GLP-1 RAs. Significant signals were observed for anxiety (aROR: 1.26, 95%CI: 1.18–1.35), depressed mood disorders (aROR: 1.70, 95%CI: 1.57–1.84) and suicidality (aROR 1.45, 95%CI: 1.29–1.63) with semaglutide, and eating disorders with all three GLP-1 RAs (aRORs between 4.17 and 6.80). The causal forest model estimated an average treatment effect of 0.0046 for semaglutide on depression and suicidality reporting, with significant heterogeneity across regions and demographic groups. Discussion: The study found no significant increase in overall psychiatric ADR reporting for GLP-1 RAs, except for eating disorders and depression/suicidality in semaglutide-treated patients. Sensitivity analyses before June 4, 2021, found no signals, aligning with RCT data. Post-marketing reports linked semaglutide to depression and suicidal ideation, prompting regulatory investigations. The causal forest model revealed significant heterogeneity in the psychiatric safety profile of semaglutide, with regional factors influencing ADR reporting. Conclusion: While GLP-1 RAs do not show a significant increase in overall psychiatric ADR reporting, findings suggest that clinicians should remain vigilant for potential depressive symptoms and suicidality, particularly in individuals with obesity treated with semaglutide since its approval for weight management.

DOI： 10.1016/j.clnu.2025.06.011

A comparison of the diagnostic ability of 1-mm computed tomography and 3-mm magnetic resonance imaging for detecting lateral pelvic lymph node metastases from rectal cancer

Kobayashi, R; Uehara, K; Ebata, T; Yatsuya, H; Li, YY; Hida, K; Hashiguchi, Y; Ishihara, S; Ogawa, S; Shiomi, A; Kawai, K; Ajioka, Y

SURGERY TODAY Vol. 55 ( 8 ) page： 1189 - 1197 2025.8

Language：English Publisher：Surgery Today

Aim: The best modality for evaluating lateral pelvic lymph node (LPLN) metastases from rectal cancer remains unclear. This study compared the diagnostic ability of 1-mm computed tomography (CT) and 3-mm magnetic resonance imaging (MRI) in identifying LPLN metastases based on size. Methods: This observational study analyzed not individual patients but 191 sides from 100 rectal cancer patients without preoperative treatment for whom preoperative CT and MRI and corresponding pathological results for LPLNs were available. A swollen LPLN was defined as an LN with a short-axis size of ≥5 mm on 1-mm CT. Results: LPLNs were detected significantly more frequently with 1-mm CT than with 3-mm MRI (p < 0.001). Among the 117 sides without swollen LPLNs, metastasis was observed in 1.7% of patients. In contrast, LPLN metastasis was confirmed in 28.4% of 74 sides with swollen LPLNs. In the evaluation of swollen LPLNs, 3-mm MRI yielded a 34% improvement in the diagnostic performance of LPLN metastasis over 1-mm CT (categorical net reclassification improvement: 0.341, p = 0.045). Conclusions: In conclusion, 1-mm CT should be performed preoperatively to evaluate LPLNs. Further evaluations can be omitted in the absence of swollen LPLNs. In patients with swollen LPLNs, a careful assessment of LPLN metastasis should be conducted via additional MRI, even in early T-stage tumors.

DOI： 10.1007/s00595-025-03018-w

Association between eveningness and low back pain among public servants in Japan: a cross-sectional analysis of the Aichi Workers' Cohort Study

Association of Adipose Tissue Insulin Resistance with Risk of Diabetes Incidents in Middle-aged Japanese Workers according to BMI states: 17 years of Follow-up of Aichi Worker's Cohort study. Open Access

Akter T, Song Z, Takada M, Hamrah MH, Wang S, Endale BT, Paththamesthrige SEP, Khine MT, Matsunaga M, Ota A, Tamakoshi K, Yatsuya H

Journal of epidemiology 2025.7

Matsunaga, M; Okegawa, R; Fujita, N; Kitajima, T; Yatsuya, H; Ota, A

EUROPEAN SPINE JOURNAL 2025.7

Language：English Publisher：European Spine Journal

Purpose: Low back pain (LBP) is a common occupational health problem. Chronotype, an individual’s preferred timing of activity and sleep, has been linked to pain perception. Previous studies have found a potential association between chronotype and LBP, although the findings were limited by small sample sizes and restricted population types. We investigated the association between evening chronotype (eveningness) and LBP in a cohort comprising public servants of various ages. Methods: We conducted a cross-sectional analysis of 4728 full-time public servants in Japan. LBP was assessed using a self-reported question. Individuals’ chronotypes were determined using the reduced Morningness–Eveningness Questionnaire. The association between chronotype and LBP was analyzed using the chi-squared test and multiple logistic regression models adjusted for age, sex, occupation, overtime work, use of the internet/email, body mass index, smoking status, exercise habits, sedentary behavior, sleep duration, sleep medication use, and depressive symptoms. Results: In total, 30% of the subjects reported LBP. The most common chronotype was intermediate type (51%), followed by morningness (38%) and eveningness (11%). A significant association between eveningness and LBP was observed. After adjusting for potential confounders, individuals with eveningness had a higher prevalence of LBP than those with morningness (36.2% vs. 28.7%; odds ratio: 1.46; 95% confidence interval: 1.16–1.83). Conclusion: Eveningness was statistically associated with LBP in a cohort of public servants. The present findings would strengthen the association’s generalizability to more varied populations.

DOI： 10.1007/s00586-025-09048-9

A comparison of modifiable risk factors for dementia among South Asian migrants and non-migrants aged 50 or older in Tasmania, Australia. Open Access

Hamrah MS, Alty J, Goldberg LR, Doherty K, Kitsos A, Bindoff A, Roccati E, Yatsuya H, Vickers JC

BMC public health Vol. 25 ( 1 ) page： 2362 2025.7

Language：English Publisher：BMC Public Health

Background: South Asian migrants are one of the fastest-growing populations in Australia, particularly in the southern island state of Tasmania. However, there is limited research evaluating their modifiable dementia risk factors. This study aimed to fill this gap by comparing risk factors in South Asian migrants to non-migrant Australians in Tasmania. Methods: A cross-sectional study was conducted with 136 South Asian migrants and 2743 non-migrant Australians aged 50 or older residing in Tasmania. Participants completed a survey questionnaire. Logistic regression models were used to assess differences in the odds of reporting modifiable dementia risk factors between the two cohorts as they responded to a survey. Results: South Asian migrants had higher odds of reporting hypertension (OR, 5.5; 95% CI, 3.5 to 8.4; p < 0.001), hypercholesterolaemia (OR, 4.4; 95% CI, 2.3 to 6.4; p < 0.001), cognitive inactivity (OR, 16.9; 95% CI, 10.4 to 28.9; p < 0.001), diabetes (OR, 5.2; 95% CI, 3.5 to 7.6; p < 0.001), smoking (OR, 3.6; 95% CI, 1.7 to 7.1; p < 0.001) and nonadherence to a Mediterranean-type diet (OR, 7.4; 95% CI, 3.5 to 18.9; p < 0.001), compared to non-migrant Australians. However, South Asian migrants had lower odds of reporting alcohol consumption (OR, 0.25; 95% CI, 0.14 to 0.43; p < 0.001). Conclusions: The risk profiles were different between South Asian migrants and non-migrant Australians, highlighting the need for targeted interventions addressing group-specific risk factors. However, the use of convenience sampling for the South Asian migrant group may limit the representativeness of the findings and affect their generalizability. However, the use of convenience sampling and the relatively small sample size of the South Asian migrant group may limit the representativeness and generalizability of the findings. Additionally, the South Asian migrant group may represent a more socioeconomically disadvantaged population compared to the non-migrant sample, which may be relatively healthier and more financially advantaged than the general Tasmanian population. The study highlights the need for targeted, culturally appropriate interventions to address these risks. Further research is needed to comprehensively assess the prevalence and determinants of modifiable dementia risk factors among South Asian migrants.

DOI： 10.1186/s12889-025-23426-4

Relationship between abdominal visceral adipose tissue and cardiovascular events in patients with acute coronary syndrome

Risk factors for intracerebral hemorrhage by five specific bleeding sites: Japan Public Health Center-based Prospective Study Reviewed Open Access

Kenichi Ariyada, Kazumasa Yamagishi, Tomomi Kihara, Isao Muraki, Hironori Imano, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

European Stroke Journal Vol. 10 ( 2 ) page： 600 - 609 2025.6

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Background:

Evaluating the risk factors for intracerebral hemorrhage is indispensable for primary prevention. However, the pathogenesis varies depending on the bleeding site, and few prospective studies have explored risk factors in detail for each site.

Participants and methods:

The Japan Public Health Center-based Prospective Study is a prospective study comprising a population-based sample of Japanese adults in 1990 (Cohort I) and in 1993 (Cohort II). A total of 34,137 participants (11,907 men and 22,230 women) were enrolled in this study and followed up until 2009 for Cohort I and until 2012 for Cohort II. The association between risk factors (age, sex, blood pressure, serum cholesterol, triglycerides, blood glucose, body mass index, smoking, and drinking status) and intracerebral hemorrhage by its bleeding site (lobes, putamen, thalamus, cerebellum, and brainstem) was assessed using Cox proportional hazards analysis.

Results:

During a median 20-year follow-up, 571 intracerebral hemorrhage events occurred. Hypertension was associated with an increased risk of total intracerebral hemorrhage, but not lobar hemorrhage. The multivariable hazard ratio (95% confidence intervals) was 2.09 (1.75–2.50) for total intracerebral hemorrhage. In contrast, a low serum total cholesterol level was associated only with lobar hemorrhage (1.73 (1.01–2.96)). Heavy drinking was associated with the risk of total and putamen hemorrhage, and obesity was associated with the risk of putamen hemorrhage.

Discussion and conclusion:

The present study identified different risk factors depending on the bleeding site of intracerebral hemorrhage.

DOI： 10.1177/23969873241290680

Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/23969873241290680

Ueyama, C; Horibe, H; Maekawa, Y; Hiramatsu, S; Yamase, Y; Funabiki, J; Takemoto, Y; Shigeta, T; Hibino, T; Kondo, T; Yatsuya, H; Ishii, H; Murohara, T

HEART AND VESSELS 2025.5

Language：English Publisher：Heart and Vessels

Abdominal visceral adipose tissue (AVAT) is associated with the incidence of cardiovascular events (CVEs). We retrospectively evaluated the association between AVAT and the incidence of CVEs in 602 patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Patients were divided into four groups according to the quartiles of AVAT areas using computed tomography. The incidence of CVEs (cardiovascular death, ACS recurrence and stroke) during the follow-up period (median 49.5 months) was evaluated. Cox analysis adjusting for cardiovascular risk factors revealed that the AVAT quartile classification exhibited a significant association with the incidence of CVEs. The risk in quartile 3 (moderate AVAT areas, ≥ 106.0 to < 142.6 cm2) was significantly lower than in quartiles 1 (low AVAT areas, < 71.0cm2; P < 0.01; hazard ratio [HR], 5.06), 2 (mild AVAT areas, ≥ 71.0 to < 106.0 cm2; P < 0.01; HR, 4.25) and 4 (severe AVAT areas, ≥ 142.6 cm2; P < 0.01; HR, 4.52). Polynomial analyses revealed that quadratic model was the most appropriate to illustrate the relationship between AVAT area and the hazard ratios for CVEs (corrected Akaike's information criterion, 49.2; R2, 0.47). The AVAT area and the incidence of CVEs exhibited a U-shaped relationship in patients with ACS undergoing PCI independent of conventional cardiovascular risk factors. The risk of CVEs was the lowest in patients with moderate AVAT areas. Evaluating AVAT may provide additional information for the assessment of long-term prognosis in patients with ACS.

DOI： 10.1007/s00380-025-02557-z

Utility of long-term systolic blood pressure variability for predicting the development of type 2 diabetes mellitus Open Access

Song, Z; Li, YY; Hong, YJ; Chiang, CF; Matsunaga, M; He, YP; Ota, A; Tamakoshi, K; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 87 ( 2 ) page： 220 - 236 2025.5

Publisher：Nagoya Journal of Medical Science

Better identification of individuals at high risk for type 2 diabetes mellitus (T2DM) requires risk-prediction models incorporating novel predictors. Accordingly, this study aimed to evaluate the merits of including long-term systolic blood pressure variability (SBPV) in predicting T2DM incidence in a Japanese cohort of 3017 participants (2446 men, 571 women; age, 36–65 years) in 2007, who were followed up until March 2019. Consecutive SBP values, recorded between 2003 and 2007, were regressed annually for each participant. The slope and root-mean-square error of the regression line were calculated for each individual to represent SBPV. The significance of SBPV was examined by adding it to a multivariate Cox model incorporating age, sex, smoking status, regular exercise, family history of diabetes, body mass index, blood levels of triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. The c-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to compare the performance of the prediction models without (Model 1) and with (Model 2) SBPV. During the 9.8-year follow-up period, 135 participants developed T2DM. Although a statistically significant difference in c-index between Model 1 (0.785) and Model 2 (0.786) was not found, the NRI (8.312% [p < 0.001]) and IDI (0.700% [p = 0.012]) demonstrated that the performance of Model 2 improved compared with Model 1. In conclusion, results suggested that long-term SBPV slightly improved predictive utility for T2DM when added to a conventional prediction model. The study was registered at University Hospital Medical Information Network Clinical Trial registry (UMIN000052544, https://www.umin.ac.jp/).

DOI： 10.18999/nagjms.87.2.220

Analysis of the changes in health-related quality of life and employment status after surgery in patients with lung cancer: a single-center longitudinal study Open Access

Association between eveningness and depressive symptoms in daytime workers: A cross-sectional analysis of the Aichi Workers’ Cohort Study Reviewed Open Access

Kazuhito Ishihara, Tsuyoshi Kitajima, Atsuhiko Ota, Hiroshi Yatsuya, Nakao Iwata

Fujita Medical Journal Vol. 11 ( 2 ) page： 64 - 69 2025.5

Language：English Publisher：Fujita Medical Society

Objectives: Eveningness (evening preference in chronotype) has been reported to be associated with a number of psychiatric problems. We examined a cross-sectional association between eveningness and depressive symptoms in daytime workers.Methods: The subjects were 4410 civil servants (71.7% male, aged 18–69 years [mean, 43.5 years]) with no history of depressive disorder who did not perform shift work, and for whom there were no missing data. The association between eveningness, determined using the reduced Morningness–Eveningness Questionnaire, and depressive symptoms, determined using the shorter form of the Central Epidemiological Studies Depression scale, was assessed with logistic regression analysis adjusted for potential confounding factors (gender, income, living alone, breakfast intake, coffee consumption, drinking habits, exercise, smoking, working hours, sleep duration, and difficulty falling asleep).Results: Of the subjects, 529 (12.0%) had eveningness, and 1408 (31.9%) reported depressive symptoms. Depressive symptoms were reported more frequently by those with eveningness than by those with other chronotypes (57.3% vs 28.5%). The association between eveningness and depression (gender- and age-adjusted odds ratio, 3.27; 95% confidence interval, 2.71–3.95) was significant after adjustment for the other confounding factors (odds ratio, 2.40; 95% confidence interval, 1.96–2.95).Conclusions: Our results suggest that eveningness is associated with depressive symptoms among day workers and that this association is independent of potential confounding factors. Further longitudinal studies are needed to examine the causal relationship.

DOI： 10.20407/fmj.2024-021

Yuka Kadomatsu, Toru Oga, Atsuhiko Ota, Hiroshi Yatsuya, Yuta Kawasumi, Harushi Ueno, Taketo Kato, Shota Nakamura, Tetsuya Mizuno, Toyofumi Fengshi Chen-Yoshikawa

General Thoracic and Cardiovascular Surgery 2025.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Objective

This study analyzed the changes in health-related quality of life (HRQOL) and employment status of patients undergoing lung cancer surgery in Japan.

Methods

This was a single-center, prospective study on patients who underwent lung anatomical resection. The eligible patients completed self-reported HRQOL and employment surveys at baseline and 6 and 12 months postoperatively. HRQOL was assessed using questionnaires including the European Organization for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C30) and EORTC QLQ and Lung Cancer module and additional social engagement and work-related stress evaluation tools.

Results

In total, 93 patients completed the baseline survey, and 80 provided survey data at 6 months postoperatively. The HRQOL scores of several factors significantly declined immediately after the surgery and then gradually improved. The EORTC global health score, which represents overall health status, returned to baseline levels at 12 months postoperatively. However, symptoms such as fatigue, dyspnea, and coughing did not return to baseline levels at 12 months postoperatively. Approximately 68% of the patients who were employed preoperatively continued to work at 12 months postoperatively.

Conclusions

Lung cancer surgery significantly affected the HRQOL and employment status of the patients within the first 6 months after surgery. For patients who decide to return to work before full recovery of QOL, we consider the need for enhanced support to assist them as they can reintegrate into work and activities of daily living.

DOI： 10.1007/s11748-025-02144-z

Other Link： https://link.springer.com/article/10.1007/s11748-025-02144-z/fulltext.html

日比野瑞歩, 李媛英, 宋澤安, 髙田碧, 洪英在, 福田知里, 王爽, 桶川龍世, 西尾七海, 服部優奈, 太田充彦, 玉腰浩司, 八谷寛

東海公衆衛生雑誌 Vol. 12 ( 2 ) page： 135 - 142 2025.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：東海公衆衛生学会

目的　中部地方の自治体職員を対象に，朝食欠食と5年後の抑うつ状態発症との関連を，愛知職域コホート研究のデータを用いて検討することを目的とした。方法　愛知職域コホート研究の2013年のベースライン調査に参加した20-54歳の対象者のうちベースライン時に抑うつがない,あるいはうつ病の治療中ではない者のうち2018年調査にも参加した2004人 (男性1452人,女性552人)を研究対象とした。抑うつ状態の評価はCenter for Epidemiologic Studies Depression Scale日本語短縮 (11項目)を使用し，8点以上を抑うつとみなした。朝食欠食は朝食摂取頻度が週6回以下と定義した。さらに，5年間の朝食欠食の変化を「非欠食 (2013年)→非欠食 (2018年)」，「欠食→非欠食」，「非欠食→欠食」，「欠食→欠食」の4パターンに分けた分析も実施した。多変量ロジスティック回帰分析を用いて，性 (男性，女性[閉経前]，女性[閉経後])，年齢，学歴，配偶者・14歳未満の子供の同居の有無，肥満 (BMI≧25 kg/m2），喫煙状況，運動頻度，アルコール摂取量，睡眠時間，ストレス，ファミリー・ワーク・コンフリクト，ワーク・ファミリー・コンフリクトを調整し，2018年の抑うつ発症のオッズ比 (OR)と95%信頼区間 (CI)を推定した。結果　2018年に新たに抑うつ状態となったのは261人 (13%)であった。朝食欠食と抑うつ発症には調整要因に独立した統計学的に有意な正の関連が認められた (OR: 1.39，95%CI: 1.01-1.90)。朝食欠食の変化パターン別の分析でも「非欠食→非欠食」群に比べて「欠食→欠食」群は抑うつ発症と有意な正の関連を示した (OR: 1.53，95%CI: 1.06-2.21)。結論　朝食欠食と抑うつ発症には調整要因に独立した正の関連が認められた。

DOI： 10.24802/tpha.2024-07

Associations of risk factors clustering with the risk of cardiovascular disease and their population attributable fraction in a worksite cohort study in urban to suburban Japan

Tajima Rina, Song Zean, Hong Young-Jae, Fukuda Chisato, Shi Xuliang, Yoshida Yuko, Shimizu Hiroko, Murakami Miharu, Kobayashi Mei, Nakano Yoshihisa, Matsunaga Masaaki, Ota Atsuhiko, Tamakoshi Koji, Yatsuya Hiroshi

Japanese Journal of Cardiovascular Disease Prevention Vol. 60 ( 1 ) page： 64 - 73 2025.2

Language：Japanese Publisher：The Japanese Society of Cardiovascular Disease Prevention

Objective: A health examination program targeting metabolic syndrome criteria, which includes abdominal obesity as a mandatory condition has been implemented to prevent cardiovascular diseases (CVD) in Japan. However, even non-obese individuals with risk factors are reportedly at a similarly increased risk of CVD. Since this group represents more in Japan than those meeting the aforementioned criteria, there is still a need to assess risk and population impact of risk factor accumulation in non-obese individuals to inform public health policy. Also, whether CVD risks according to the risk factor accumulation differ by the presence of obesity was mostly examined in community settings, leaving necessity for studies in urban employees, who may have different lifestyles and higher rates of coronary artery disease. This study aimed to estimate CVD risks and population-attributable fractions (PAFs) by the number of CVD risk factors, stratified by obesity status, in a cohort of local government employees.Methods: This study included 7,179 participants from the Aichi Workers' Cohort Study recruited between 2002-2008 without histories of CVD and cancer or missing data at baseline and followed-up for at least one year. The participants were categorized into four groups (0, 1, 2, or ≥3) according to the number of the following risk factors: hypertension, diabetes, high LDL cholesterol, kidney disease and, smoking, which were further divided by obesity status. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) and the 95% confidence intervals (CIs) as well as PAFs for CVD incidence.Results: During follow-up, 99 developed CVD (66 non-obese and 33 obese). Among non-obese participants, compared to those with no risk factors, the HR for CVD incidence increased with the number of risk factors: 2.43 (95%CI: 1.14-5.21), 3.96 (95%CI: 1.79-8.74), and 4.75 (95%CI: 1.73-13.0) for one, two and three or more risk factors, respectively. In the obese group, the HRs compared to non-obese individuals with no risk factors increased similarly according to the number of risk factors: 4.31 (95%CI: 1.85-10.00), 3.75 (95%CI: 1.47-9.57), and 7.53 (95%CI: 2.86-19.8) for one, two, and three or more risk factors, respectively. The PAFs were 16.7%, 16.6%, and 5.6% in the non-obese group and 10.9%, 6.7%, and 7.0% in the obese group for one, two, and three or more risk factors, respectively.Conclusion: Accumulation of risk factors was associated with increased CVD risk regardless of obesity status.

DOI： 10.11381/jjcdp.60.1_64

Sex-specific association of comorbid heart failure on mortality after Alzheimer's disease diagnosis in older adults aged 75 years and above: A health insurance claims data analysis in Japan Open Access

Masaaki Matsunaga, Shinichi Tanihara, Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota

Journal of Alzheimer’s Disease Vol. 103 ( 3 ) page： 749 - 757 2025.2

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Background

Research on the influence of heart failure on mortality after Alzheimer's disease diagnosis is limited.

Objective

To evaluate the association between comorbid heart failure and mortality following Alzheimer's disease diagnosis, particularly considering sex differences.

Methods

We analyzed administrative claims data from Japan, involving 32,363 individuals (11,064 men and 21,299 women) aged 75 or older newly diagnosed with Alzheimer's disease, with 7% having comorbid heart failure. Cox proportional hazard models and population attributable fractions (PAFs) were used to evaluate the association between comorbid heart failure and mortality within one year following Alzheimer's disease diagnosis.

Results

Individuals with Alzheimer's disease and heart failure had a multivariate-adjusted hazard ratio of 1.51 (95% confidence interval [CI], 1.32–1.73) for mortality during the one-year follow-up period compared to those with Alzheimer's disease and without heart failure. Subgroup analysis by sex revealed a higher mortality hazard ratio in women of 1.63 (95% CI, 1.36–1.95) than that in men of 1.39 (95% CI, 1.13–1.71). Further age and sex subgroup analysis indicated that women across all age brackets—75–79, 80–84, and ≥ 85 years—had higher mortality hazard ratios. The PAF for heart failure increased with age in both sexes, with women having higher PAFs than men, and the sex difference in PAF being most pronounced in the 75–79 age category (men: 1.4%, women: 4.0%).

Conclusions

Hazard ratios and PAFs for mortality associated with comorbid heart failure in newly diagnosed Alzheimer's disease are higher in women than in men, which persists across all age subgroups.

DOI： 10.1177/13872877241305813

Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/13872877241305813

Exploring the Development of Safety Culture among Physicians with Text Mining of Patient Safety Reports: A Retrospective Study Reviewed Open Access

Daisuke Koike, Masahiro Ito, Akihiko Horiguchi, Hiroshi Yatsuya, Atsuhiko Ota

International Journal for Quality in Health Care Vol. 37 ( 1 ) page： mzae108 2025.1

Associations of maternal urinary nitrophenol concentrations with adverse birth outcomes and neurodevelopment delay at 4 years of age: The Japan environment and children's study Reviewed Open Access

Kayo Kaneko, Yuki Ito, Takeshi Ebara, Hiroshi Yatsuya, Mayumi Sugiura-Ogasawara, Shinji Saitoh, Makiko Sekiyama, Tomohiko Isobe, Michihiro Kamijima

Environmental Research Vol. 264 ( Pt 1 ) page： 120290 - 120290 2025.1

Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20-54 years: A three decades comparative study (1990-2021) using Global Burden of Disease study data. Open Access

Yang D, Fan G, Cheng J, Meng Q, Liu K, Shirai K, Yatsuya H, Chen R, Zhang Y

Tobacco induced diseases Vol. 23 2025

RISK FACTORS FOR INTRACEREBRAL HEMORRHAGE BY BLEEDING SITE

Ariyada, K; Yamagishi, K; Kihara, T; Muraki, I; Imano, H; Kokubo, Y; Saito, I; Yatsuya, H; Inoue, M; Tsugane, S; Iso, H; Sawada, N

ATHEROSCLEROSIS Vol. 399 2024.12

Chronotype and leisure-time physical activity among civil servants in Japan: a cross-sectional analysis of the Aichi workers’ cohort study Reviewed Open Access

Ryusei Okegawa, Yupeng He, Masaaki Matsunaga, May Thet Khine, Yuanying Li, Tsuyoshi Kitajima, Hiroshi Yatsuya, Atsuhiko Ota

Archives of Public Health Vol. 82 ( 1 ) page： 205 2024.11

Association between predicted level of water turnover deficit and all-cause and cause-specific mortalities among Japanese adults: The Japan Collaborative Cohort Study Reviewed International journal

Daiki Watanabe, Isao Muraki, Hiroshi Yatsuya, Akiko Tamakoshi

The American Journal of Clinical Nutrition 2024.9

Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers’ Cohort Study Reviewed

Jingyi Lin, Zean Song, Yuanying Li, Chifa Chiang, Yoshihisa Hirakawa, Yoshihisa Nakano, Young-Jae Hong, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

Journal of Epidemiology Vol. 34 ( 9 ) page： 428 - 433 2024.9

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: The term “nonrestorative sleep (NRS)” refers to an unrefreshed feeling at wake-up and is a domain of poor sleep quality. Previous research has demonstrated that NRS is linked to a number of diseases and adverse health outcomes, but less is known regarding the link between NRS and diabetes, particularly in Japanese.Methods: We studied 3,665 middle-aged male participants of the Aichi Workers’ Cohort Study who were followed-up from 2002 through 2019. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS adjusted for potential confounding variables.Results: During a median follow-up of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to participants without NRS (9.3/1,000 person-years). In the fully adjusted model, individuals who reported having NRS had a significantly higher risk of developing T2DM (HR1.36; 95% CI, 1.10–1.67). The association was observed only in participants under 50 years old (HR 1.82; 95% CI, 1.36–2.43), not in the older (50 years or older) participants (P for interaction = 0.025). In contrast, stratified analyses by the presence of shift work, obesity, or sleep duration showed similar associations in all the strata.Conclusion: NRS was associated with higher risk of T2DM in middle-aged Japanese male workers independent of a variety of lifestyle factors and other sleep problems.

DOI： 10.2188/jea.JE20230184

Mortality after partner’s cancer diagnosis or death: A population-based prospective cohort study in Japan Reviewed

Makiuchi Takeshi, Kakizaki Masako, Sobue Tomotaka, Kitamura Tetsuhisa, Yatsuya Hiroshi, Yamaji Taiki, Iwasaki Motoki, inoue Manami, Tsugane Shoichiro, Sawada Norie

Journal of Epidemiology Vol. advpub ( 0 ) 2024.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: The health statuses of closely connected individuals are interdependent. Little is known about mortality risk associated with partner’s cancer diagnosis and cause-specific mortality risk associated with partner’s death.Methods: Relative risks for all-cause and cause-specific mortality following a partner’s cancer diagnosis or death compared to the period when the partner is cancer-free and alive were investigated in the population-based prospective cohort study that enrolled 140,420 people at the age between 40-69 in 1990-1994.Results: 55,050 participants (27,665 men and 27,385 women) who were identified as married couples were followed-up for 1,073,746.1 (518,368.5 in men and 555,377.6 in women) person-years, during which 9,816 deaths (7,217 in men and 2,599 in women) were observed. After a partner’s cancer diagnosis, the mortality rate ratio (MRR) of all-cause mortality was not increased among both men and women, while an increase of externally-caused MRR was observed. The suicide MRR significantly increased among men (MRR = 2.90 [95% CI, 1.70–4.93]) and it persisted for more than 5 years. After a partner’s death, the MRRs of all-cause, cardiovascular disease (CVD), respiratory disease (RD), and externally-caused mortality significantly increased only among men. Stratified analysis by smoking status among men showed significantly increased MRRs of CVD and RD mortality among former/current smokers, but not among never-smokers.Conclusion: Partner’s cancer diagnosis did not increase all-cause mortality risk, but increased externally-caused mortality risk, especially suicide among men. The impact of partner’s death on mortality risk differed by the mortality causes and sex, and smoking affected some of cause-specific mortality risk.

DOI： 10.2188/jea.JE20240114

Impact of diabetes on mortality and hospitalization after dementia diagnosis: Health insurance claims data analysis Reviewed

Masaaki Matsunaga, Shinichi Tanihara, Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota

Geriatrics & Gerontology International Vol. 24 ( 8 ) page： 773 - 781 2024.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim

Japan faces a public health challenge of dementia, further complicated by the increasing complications from diabetes within its rapidly aging population. This study assesses the impact of diabetes on mortality and hospitalization among individuals aged ≥75 years with new dementia diagnoses.

Methods

We analyzed administrative claims data in Japan from 73 324 individuals aged ≥75 years with dementia, of whom 17% had comorbid diabetes. Dementia and diabetes were identified from the International Classification of Diseases, Tenth Revision codes. We used Kaplan–Meier survival analysis, Cox proportional hazards analysis, and population attributable fractions (PAFs) to evaluate the impact on mortality and hospitalization after dementia diagnosis.

Results

One‐year mortality and 1‐year hospitalization probabilities in individuals with dementia and diabetes (10.3% and 31.7%, respectively) were higher than those without diabetes (8.3% and 25.4%, respectively). The adjusted hazard ratios for individuals with diabetes, as compared to those without, were 1.126 (95% confidence interval [CI], 1.040–1.220) for mortality and 1.191 (95% CI, 1.140–1.245) for hospitalization. The PAFs from the comorbidity of dementia and diabetes were 2.2% for mortality and 3.1% for hospitalization. Subgroup analysis showed that the PAFs were highest in men aged 75–79 years and women aged 80–84 years for mortality and in individuals aged 75–79 for hospitalization.

Conclusion

During the early postdiagnosis period, comorbid diabetes increases mortality and hospitalization risks in older adults with dementia. The variation in disease burden across age groups underscores the need for age‐specific health care strategies to manage comorbid diabetes in individuals with dementia. Geriatr Gerontol Int 2024; 24: 773–781.

DOI： 10.1111/ggi.14926

Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer. Reviewed

Imamura Y, Kato T, Nomata Y, Okado S, Watanabe H, Kawasumi Y, Nakanishi K, Kadomatsu Y, Ueno H, Nakamura S, Mizuno T, Hase T, Tanaka I, Ishii M, Yatsuya H, Chen-Yoshikawa TF

Anticancer research Vol. 44 ( 8 ) page： 3451 - 3461 2024.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background/Aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSCLC remain unclear. The objective of the study was to compare the efficacy of ICIs and chemotherapy with conventional chemotherapy only in patients with postoperative recurrence of epidermal growth factor receptor (EGFR) wild-type NSCLC. Patients and Methods: A retrospective analysis was performed on patients who underwent anatomical lung resection at the Nagoya University Hospital and were treated for postoperative recurrence of wild-type EGFR NSCLC. This study evaluated the prognosis for postoperative recurrence, including ICIs treatment and other clinicopathological factors. Results: Of the 83 patients included in the analysis, 20 patients underwent chemotherapy and 63 patients underwent chemotherapy combined with ICIs. The combination of ICIs and chemotherapy significantly prolonged survival after recurrence (median survival: 33.1 months vs. 22.0 months, p=0.01). In the ICIs group, no significant differences in survival were detected between patients with different programmed death ligand 1 (PD-L1) status (Tumor Proportion Scores: <1%, 1%-49%, ≥50%, p=0.27). Multivariate analysis revealed that postoperative distant recurrence was a significant poor prognostic factor for survival after recurrence (HR=1.85, 95% CI=1.06-3.25, p=0.03), and combining ICIs with chemotherapy significantly improved survival after recurrence (HR=0.43, 95% CI=0.24-0.78, p<0.01). Conclusion: Combination of ICIs with chemotherapy significantly prolonged survival of postoperative recurrence with wild-type EGFR NSCLC regardless of PD-L1 status.

DOI： 10.21873/anticanres.17165

Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

Journal of atherosclerosis and thrombosis Vol. advpub ( 0 ) 2024.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

AIM: The constellation of cardiovascular disease (CVD) risk factors greatly impacts the lifetime risk (LTR) of incident CVD, but the LTR has not been thoroughly evaluated in the Japanese population. METHODS: We conducted a prospective study involving a total of 25,896 individuals 40-69 years old without a history of CVD in 1995 (Cohort I) and 1993-1994 (Cohort II) in Japan. CVD risk factors (blood pressure, non-high-density lipoprotein [HDL] cholesterol levels, smoking status, and glucose concentrations) were used to stratify them by risk. The sex-specific LTR of incident coronary heart disease, stroke, atherosclerotic CVD, and total CVD were estimated for participants 45 years old in the 4 risk categories with the cumulative incidence rate, adjusting for the competing risk of death. RESULTS: We found apparent differences in the LTR of total CVD according to the risk stratification. Individuals with ≥ 2 of the risk factors of blood pressure ≥ 140/90 mmHg or treated, non-HDL cholesterol level ≥ 170 mg/dL or treated, current smoker, and diabetes had substantially higher adjusted LTRs of CVD than those in other groups, with a LTR of 26.5% (95% confidence interval, 24.0%-29.0%) for men and 15.3% (13.1%-17.5%) for women at 45 years. The LTR of incident stroke was the highest among CVDs, and the presence of hypertension and diabetes mellitus strongly influenced the LTR of total CVD. CONCLUSION: The impact of risk accumulation on LTR of CVD was greater in men, and 1 in 4 men with ≥ 2 major risk factors at 45 years of age developed CVD in their lifetime.

DOI： 10.5551/jat.64934

Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study Reviewed

Young Jae Hong, Rei Otsuka, Zean Song, Chisato Fukuda, Rina Tajima, Jingyi Lin, Mizuho Hibino, Mei Kobayashi, Yupeng He, Masaaki Matsunaga, Atsuhiko Ota, Yoshihisa Nakano, Yuanying Li, Koji Tamakoshi, Hiroshi Yatsuya

Geriatrics & Gerontology International Vol. 24 ( 7 ) page： 700 - 705 2024.7

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Aim

Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long‐term cohort study in Japan.

Methods

We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age‐ and energy‐adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis.

Results

The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44).

Conclusions

In this study, milk intake in middle‐aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

DOI： 10.1111/ggi.14916

Relationship between size of pharyngeal and palatine tonsils and apnea–hypopnea index in pediatric obstructive sleep apnea Reviewed

定年退職期の就労継続と脳灰白質容積の10年間の変化

大塚礼, 西田裕紀子, 丹下智香子, 八谷寛, 久保田彩, 安藤富士子, 下方浩史, 加藤隆司, 中村昭範, 荒井秀典

日本老年医学会雑誌 Vol. 61 ( Suppl. ) page： 141 - 141 2024.5

20歳から老年期にかけての体重変動はフレイル発症関連要因である愛知職域コホート研究

洪英在, 大塚礼, 宋澤安, 福田知里, 小林芽生, 松永眞章, 太田充彦, 李媛英, 玉腰浩司, 八谷寛

日本老年医学会雑誌 Vol. 61 ( Suppl. ) page： 133 - 133 2024.5

Kaneko Masamichi, Hirata Masatoshi, Kimura Ayami, Inada Hiroya, Shikano Kazuki, Ito Satoshi, Okano Takayuki, Yatsuya Hiroshi, Nakata Seiichi

Fujita Medical Journal Vol. 10 ( 2 ) page： 60 - 63 2024.5

Language：English Publisher：Fujita Medical Society

Objective: To determine whether the combination of the pharyngeal tonsil grade and palatine tonsil grade results in differences in the apnea–hypopnea index (AHI) and to determine whether each parameter separately (pharyngeal tonsil grade and palatine tonsil grade) results in differences in severe obstructive sleep apnea (OSA).Methods: This cross-sectional study involved 107 children (mean age, 7.2 years; range, 4–12 years) suspected of having OSA because of snoring or sleep-related complaints. The patients underwent polysomnography, and their palatine and pharyngeal tonsils were graded.Results: In examining whether the palatine tonsils and pharyngeal tonsils could be risk factors for severe OSA, the adjusted odds ratios were 4.42 for palatine tonsil grade 4 versus 1–3 and 10.40 for pharyngeal tonsil grade 4 versus 1–3; both were highly statistically significant. We also found that the AHI when both the pharyngeal and palatine tonsils were grade 4 was higher than the AHI expected for the pharyngeal and palatine tonsils alone.Conclusions: The combination of grade 4 pharyngeal tonsils and grade 4 palatine tonsils resulted in an AHI much higher than the AHI of other combinations (pharyngeal tonsils grades 1–3 and 4, palatine tonsils grades 1–3 and 4). We believe that grade 4 pharyngeal tonsils and grade 4 palatine tonsils have a great influence on severe OSA and that grade 4 pharyngeal tonsils increase the AHI.

DOI： 10.20407/fmj.2023-011

Factors influencing interprofessional collaboration in long-term care from a multidisciplinary perspective: a case study approach. Reviewed

日本人中年男性における長期的な収縮期血圧変動とうつ状態発症との関連

小林芽生, 李媛英, 宋澤安, 洪英在, 日比野瑞歩, 田島里菜, 太田充彦, 大塚礼, 玉腰浩司, 八谷寛

日本循環器病予防学会誌 Vol. 59 ( 2 ) page： 127 - 127 2024.4

Yoshida Y, Hirakawa Y, Hong YJ, Mamun MR, Shimizu H, Nakano Y, Yatsuya H

Home health care services quarterly page： 1 - 20 2024.3

Authorship：Last author Language：English Publisher：Home Health Care Services Quarterly

Systematic assessments of interprofessional collaboration barriers and enablers in long-term care settings are critical for delivering person-centered healthcare. However, research on factors influencing interprofessional collaboration in long-term care settings is limited. For this study, 65 healthcare professionals across multiple facilities experienced in long-term care in Japan participated in online focus group discussions and individual interviews to discuss cases. The qualitative data were analyzed using qualitative content analysis. Seven themes emerged: coordination, the need for care manager training, hierarchy among healthcare professionals, specialization but not the mind-set of overspecialization, casual conversations, electronic group communication tools, and excessive fear of personal information protection. These findings highlight the need to develop coordinator roles and for interprofessional education on the proper approach to personal information protection laws. Furthermore, daily casual conversations, the use of online platforms, and the prevention of patients being left behind due to overspecialization are required.

DOI： 10.1080/01621424.2024.2331452

Prediction model of the risk for lateral local recurrence in locally advanced rectal cancer without enlarged lateral lymph nodes: Lessons from a Japanese multicenter pooled analysis of 812 patients Reviewed

新型コロナウイルス流行期の超過死亡と関連要因に関する主張への懸念 Reviewed

鈴木貞夫, 尾島俊之, 永田知里, 八谷寛, 若井建志

東海公衆衛生雑誌 Vol. 11 ( 2 ) page： 143 - 144 2024.3

Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers’ cohort study Reviewed International coauthorship

Abubakr Ahmed Abdullah Al-shoaibi, Yuanying Li, Zean Song, Young Jae Hong, Chifa Chiang, Yoshihisa Nakano, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

Obesity Research & Clinical Practice Vol. 18 ( 2 ) page： 101 - 108 2024.3

Ogura, A; Shiomi, A; Yamamoto, S; Komori, K; Hamamoto, H; Manabe, S; Miyakita, H; Okuda, J; Yatsuya, H; Uehara, K

ANNALS OF GASTROENTEROLOGICAL SURGERY Vol. 8 ( 2 ) page： 284 - 292 2024.3

Language：English Publisher：Annals of Gastroenterological Surgery

Aim: Although the oncological impact of lateral lymph node dissection on enlarged lateral lymph nodes has been gradually accepted over the last decade, that on lateral lymph nodes without swelling remains doubtful. This study aimed to develop a prediction model for the future risk of lateral local recurrence and to clarify the value of adding lateral lymph node dissection in locally advanced rectal cancer without enlarged lateral lymph nodes. Methods: This retrospective, multi-institutional study recruited 812 patients with cStage II/III low rectal cancer without enlarged lateral lymph nodes <7 mm. Total lateral local recurrence was a hypothetical value of future risk of lateral local recurrence when lateral lymph node dissection was never performed. Results: Overall, total lateral local recurrences were observed in 67 patients (8.3%). In the multivariate analyses, the strongest risk factor for total local recurrences was no preoperative chemoradiotherapy (odds ratio [OR][95%Cl]: 33.2 [4.56–241.7], P < 0.001), followed by tumor distance ≤40 mm (OR [95%Cl]: 2.71 [1.51–4.86], P < 0.001) and lateral lymph node 5–7 mm (OR[95%Cl]: 2.38 [1.26–4.48], P = 0.007). In patients with lateral lymph nodes of 5–7 mm, the total lateral recurrence rate was 4.8% after preoperative chemoradiotherapy. Lateral lymph node dissection could reduce from a total lateral local recurrence of 21.6% to an actual lateral local recurrence of 8.0% in patients without preoperative treatment. Conclusion: We introduce a novel prediction model of future risk of lateral local recurrences, which has the potential to enable us to indicate lateral lymph node dissection selectively according to the patients' risks.

DOI： 10.1002/ags3.12742

Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis Reviewed

Masaaki Matsunaga, Yupeng He, May Thet Khine, Xuliang Shi, Ryusei Okegawa, Yuanying Li, Hiroshi Yatsuya, Atsuhiko Ota

Journal of Cancer Survivorship 2024.2

The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. Reviewed International journal

Hanson Gabriel Nuamah, Yuanying Li, Hiroshi Yatsuya, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Vol. 33 ( 2 ) page： 107486 - 107486 2024.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The associations between body mass index (BMI) and stroke subtypes, particularly intracerebral hemorrhage, have not been consistent. Such inconsistencies may be due to differences in the age at which BMI was obtained. We examined the possible age modifications in the association between BMI and stroke risk. MATERIALS AND METHODS: We followed 88,754 participants, aged 40-69 years at baseline (1990-1994), of the Japan Public Health Center-based prospective (JPHC) study for stroke incidence. BMI was obtained using self-reported body weight and height, which were categorized using the following cut-off points: 18.5, 21, 23, 25, 27.5, and 30 kg/m2. Time-dependent Cox proportional hazards models that updated BMI and covariates using 5- and 10-year questionnaire responses were used to estimate hazard ratios and 95 % confidence intervals. The analyses were stratified by age group (40-59 and ≥60 years) and the age of the individuals was updated. RESULTS: During the median follow-up period of 19 years, we documented 4,690 strokes, including 2,781 ischemic strokes and 1,358 intracerebral hemorrhages. After adjusting for sex, age, smoking, alcohol consumption, leisure-time physical activity, history of hypertension, dyslipidemia, and diabetes mellitus, we observed a positive linear association between BMI and ischemic stroke (linear trend, p < 0.001) in both age groups (interaction p>0.05). In contrast, a curvilinear association between BMI and intracerebral hemorrhage was observed in both the middle (curvilinear trend, p=0.017) and the older group (curvilinear trend, p=0.098) (interaction p>0.05). CONCLUSION: BMI and stroke associations did not vary significantly with age, although the association may differ according to subtype.

DOI： 10.1016/j.jstrokecerebrovasdis.2023.107486

肥満疫学研究の最前線高齢期の身体指標の加齢変化と要介護予防

大塚礼, 八谷寛

肥満研究 Vol. 29 ( 合同学術集会抄録集 ) page： 131 - 131 2023.11

The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease Reviewed International journal

Suzuki Daijiro, Suzuki Takanori, Fujino Masayuki, Asai Yumiko, Kojima Arisa, Uchida Hidetoshi, Saito Kazuyoshi, Kusuki Hirofumi, Li Yuanying, Yatsuya Hiroshi, Sadanaga Tsuneaki, Hata Tadayoshi, Yoshikawa Tetsushi

Fujita Medical Journal Vol. 9 ( 4 ) page： 275 - 281 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Fujita Medical Society

Objectives: The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD.Methods: We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan).Results: The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer–Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit.Conclusions: The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.

DOI： 10.20407/fmj.2023-001

Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers’ cohort study, 2002–2019 Reviewed International coauthorship

KM Saif-Ur-Rahman, Young Jae Hong, Yuanying Li, Masaaki Matsunaga, Zean Song, Masako Shimoda, Abubakr Al-Shoaibi, Yupeng He, Md Razib Mamun, Yukiko Hirano, Chifa Chiang, Yoshihisa Hirakawa, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Rei Otsuka, Hiroshi Yatsuya

Heliyon Vol. 9 ( 11 ) page： e21931 - e21931 2023.11

Good death for people living with dementia: a qualitative study Reviewed

Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

BMC GERIATRICS Vol. 23 ( 1 ) page： 665 2023.10

Authorship：Corresponding author Language：English Publisher：BMC Geriatrics

Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

DOI： 10.1186/s12877-023-04395-y

Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis. Reviewed International coauthorship International journal

Morgan E Grams, Josef Coresh, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Aditya Surapaneni, Natalia Alencar de Pinho, Amanda Anderson, Lawrence J Appel, Johan Ärnlöv, Fereidoun Azizi, Nisha Bansal, Samira Bell, Henk J G Bilo, Nigel J Brunskill, Juan J Carrero, Steve Chadban, John Chalmers, Jing Chen, Elizabeth Ciemins, Massimo Cirillo, Natalie Ebert, Marie Evans, Alejandro Ferreiro, Edouard L Fu, Masafumi Fukagawa, Jamie A Green, Orlando M Gutierrez, William G Herrington, Shih-Jen Hwang, Lesley A Inker, Kunitoshi Iseki, Tazeen Jafar, Simerjot K Jassal, Vivekanand Jha, Aya Kadota, Ronit Katz, Anna Köttgen, Tsuneo Konta, Florian Kronenberg, Brian J Lee, Jennifer Lees, Adeera Levin, Helen C Looker, Rupert Major, Cheli Melzer Cohen, Makiko Mieno, Mariko Miyazaki, Olivier Moranne, Isao Muraki, David Naimark, Dorothea Nitsch, Wonsuk Oh, Michelle Pena, Tanjala S Purnell, Charumathi Sabanayagam, Michihiro Satoh, Simon Sawhney, Elke Schaeffner, Ben Schöttker, Jenny I Shen, Michael G Shlipak, Smeeta Sinha, Benedicte Stengel, Keiichi Sumida, Marcello Tonelli, Jose M Valdivielso, Arjan D van Zuilen, Frank L J Visseren, Angela Yee-Moon Wang, Chi-Pang Wen, David C Wheeler, Hiroshi Yatsuya, Kunihiro Yamagata, Jae Won Yang, Ann Young, Haitao Zhang, Luxia Zhang, Andrew S Levey, Ron T Gansevoort

JAMA Vol. 330 ( 13 ) page： 1266 - 1277 2023.10

Language：English Publishing type：Research paper (scientific journal)

IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. OBJECTIVE: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. DESIGN, SETTING, AND PARTICIPANTS: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. EXPOSURES: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). MAIN OUTCOMES AND MEASURES: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. RESULTS: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, including those in the mildest categories of chronic kidney disease. For example, among people with a UACR less than 10 mg/g, an eGFR of 45 to 59 mL/min/1.73 m2 based on creatinine alone was associated with significantly higher hospitalization rates compared with an eGFR of 90 to 104 mL/min/1.73 m2 (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.3]; 161 vs 79 events per 1000 person-years; excess absolute risk, 22 events per 1000 person-years [95% CI, 19-25 events per 1000 person-years]). CONCLUSIONS AND RELEVANCE: In this retrospective analysis of 114 cohorts, lower eGFR based on creatinine alone, lower eGFR based on creatinine and cystatin C, and more severe UACR were each associated with increased rates of 10 adverse outcomes, including adverse kidney outcomes, cardiovascular diseases, and hospitalizations.

DOI： 10.1001/jama.2023.17002

Applicability of a web-based 24-hour dietary recall tool for Japanese populations in large-scale epidemiological studies. Reviewed

孤食は、世帯構成や孤独感とは独立した抑うつ関連因子である愛知職域コホート研究

洪英在, 大塚礼, 平川仁尚, 太田充彦, 玉腰浩司, 八谷寛

日本公衆衛生学会総会抄録集 Vol. 82回 page： 286 - 286 2023.10

Yoshie Hose, Junko Ishihara, Ayaka Kotemori, Misako Nakadate, Sachiko Maruya, Junta Tanaka, Hiroshi Yatsuya, Atsuko Aoyama, Chifa Chiang, Tsuneo Konta, Takamasa Kayama, Yoshiyuki Ueno, Manami Inoue, Norie Sawada, Shoichiro Tsugane, Ribeka Takachi

Journal of epidemiology Vol. 33 ( 8 ) page： 419 - 427 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Recent innovations in information and communication technology have made it possible to assess diet using web-based methods; however, their applicability in the general population remains unclear. Hence, we aimed to examine the applicability of a web-based 24-hour dietary recall (24HR) tool to large-scale epidemiological studies by determining the sampling rate and characteristics of randomly selected participants (partially entire population) from a Japanese cohort study. METHODS: In total, 5,013 individuals were recruited from a cohort of 21,537 individuals, and 975 agreed to participate in this study. The participants selected either self-administered web-based dietary 24HR (self-administered 24HR) or interviewer-administered telephone-based 24HR (interviewer-administered 24HR) as the method for the dietary assessment and answered questions regarding the acceptability of the system. RESULTS: The response rate of the 975 participants was 19.4%, and approximately 4.5% of the total study population. About half of them chose the self-administered 24HR (46.9%). The median time required for the self-administered and interviewer-administered 24HR was 25 and 27 minutes, respectively. In the self-administered 24HR, older people, regardless of sex, tended to require a longer time, and approximately 60% of the participants rated the ease of use of the system as "somewhat difficult" or "difficult." CONCLUSIONS: Characteristics of the participants in this study were not systemically different from those of the entire study population. Improvements in approach for the entering cooking details and the dish name selection may be necessary for better acceptability in order to be accepted as a self-administered 24HR.

DOI： 10.2188/jea.JE20220071

Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease - The Japan Public Health Center-Based Prospective Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

Circulation journal : official journal of the Japanese Circulation Society Vol. 87 ( 9 ) page： 1196 - + 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

BACKGROUND: There is considerable interest in the trending discrepancy between ischemic heart disease (IHD) and heart failure (HF) in vital statistics. Clinically, acute myocardial infarction (AMI) and stroke are closely associated with HF, but their contribution to HF as the underlying cause of death (UCD) is unclear.Methods and Results: In 1990 and 1992-1993, we enrolled a total of 140,420 residents of Japanese nationality (aged 40-69 years) from 11 public health center areas. We prospectively examined the occurrence of cardiovascular disease (CVD), including AMI, sudden cardiac death within 1 h (SCD), and stroke, and analyzed the 14,375 participants without a history of CVD at baseline who died during the 20-year follow-up. A time-dependent Cox proportional hazards model was used to estimate hazard ratios and the population attributable fraction (PAF) of AMI, AMI+SCD, stroke, and CVD for deaths due to HF, IHD, and cerebrovascular disease as the UCD, adjusted for individuals' lifestyles and comorbid conditions. The PAF of AMI for HF deaths was 2.4% (95% confidence interval [CI] 1.7-2.9%), which increased to 12.0% (95% CI 11.6-12.2%) for AMI+SCD. The PAF of CVD-attributed HF deaths was estimated to be 17.6% (95% CI 15.9-18.9%). CONCLUSIONS: HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.

DOI： 10.1253/circj.CJ-22-0805

Associations between changes in social contact pattern and the mental health status of Chinese adults: cross-sectional findings Reviewed International coauthorship

Zhang, JY; Zhou, S; Wang, Q; Hou, FF; Han, X; Shen, GD; Chiang, CF; Yatsuya, H; Zhang, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 3 ) page： 476 - 489 2023.8

Language：English Publisher：Nagoya Journal of Medical Science

The study aims to examine the associations between social contact pattern changes and mental health status, including depression, anxiety, and loneliness, among Chinese adults in the context of coronavirus disease 2019 (COVID-19). Data on social contact patterns before and after the outbreak of COVID-19 were obtained from 3511 participants. Mental health (ie, depression, anxiety, and loneliness) was assessed by the 9-item Patient Health Questionnaire, Dark Future Scale, and the 9-scale Three-Item Loneliness Scale, respectively. Poisson regression analyses revealed that the participants who had increased in-person communication were more likely to have mental disorders [depression: prevalence ratio (PR)=1.13, 95% confidence interval (CI): 1.02, 1.26; anxiety: PR=1.15, 95% CI: 1.01, 1.30]. The current study concluded that the in-person communication increase before and after the outbreak of COVID-19 was associated with mental disorders among Chinese adults.

DOI： 10.18999/nagjms.85.3.476

Impact of combined resection of the internal iliac artery on loss of volume of the gluteus muscles after pelvic exenteration Reviewed

Risk and population attributable fraction of stroke subtypes in Japan. Reviewed

Hiroshi Yatsuya, Kazumasa Yamagishi, Yuanying Li, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Manami Inoue, Shoichiro Tsugane, Hiroyasu Iso, Norie Sawada

Journal of epidemiology Vol. 34 ( 5 ) page： 211 - 217 2023.7

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Associations of major risk factors for stroke with total and each type of stroke as well as subtypes of ischemic stroke and their population attributable fractions had not been examined comprehensively. METHODS: Participants of the Japan Public Health Center-based prospective (JPHC) Study Cohort II without histories of cardiovascular disease and cancer (n=14,797) were followed from 1993 through 2012. Associations of current smoking, hypertension, diabetes, overweight (body mass index ≥ 25 kg/m2), non-high-density lipoprotein cholesterol (non-HDLC) categories, low HDLC (< 40 mg/dL), urine protein, and history of arrhythmia were examined in a mutually-adjusted Cox regression model that included age and sex. Population attributable fraction (PAF) was estimated using the hazard ratios and the prevalence of risk factors among cases. RESULTS: Subjects with hypertension were 1.63 to 1.84 times more likely to develop any type of stroke. Diabetes, low HDLC, current smoking, overweight, urine protein, and arrhythmia were associated with risk of overall and ischemic stroke. Hypertension and urine protein were associated with risk of intracerebral hemorrhage while current smoking, hypertension, and low non-HDLC were associated with subarachnoid hemorrhage. Hypertension alone accounted for more than a quarter of stroke incidence, followed by current smoking and diabetes. High non-HDLC, current smoking, low HDLC, and overweight contributed mostly to large-artery occlusive stroke. Arrhythmia explained 13.2% of embolic stroke. Combined PAFs of all the modifiable risk factors for total, ischemic and large-artery occlusive strokes were 36.7 and 44.5% and 61.5%, respectively. CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.

DOI： 10.2188/jea.JE20220364

Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers. Reviewed International coauthorship

Ehab S Eshak, Sachiko Baba, Hiroshi Yatsuya, Hiroyasu Iso, Yoshihisa Hirakawa, Eman M Mahfouz, Chiang Chifa, Ryoto Sakaniwa, Ayman S El-Khateeb

Journal of epidemiology Vol. 33 ( 7 ) page： 360 - 366 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Work-family conflicts (total-WFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association. METHODS: In a cross-cultural study of 4792 Japanese Aichi Workers' Cohort study participants and 3109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured total-WFCs and Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. Logistic regression models estimated odds ratios (ORs) of having depression and a high-ikigai across levels of total-WFCs (low, moderate, and high), and the PROCESS macro of Hayes tested the mediation effect. RESULTS: The prevalence of high total-WFCs, depression, and having a high-ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men. Compared with participants with low total-WFCs, the multivariable ORs (95% CIs) of depression in Japanese women and men with high total-WFCs were 4.11 (2.99-5.65) and 5.42 (4.18-7.02), and those in Egyptian women and men were 4.43 (3.30-5.95) and 4.79 (3.53-6.48). The respective ORs of having a high-ikigai were 0.46 (0.33-0.64) and 0.40 (0.31-0.52) in Japanese women and men and were 0.34 (0.24-0.48) and 0.28 (0.20-0.39) in Egyptian women and men. No interaction between total-WFCs and country was observed for the associations with depression or ikigai. Ikigai has mediated (up to 18%) the associations between the total-WFCs and depression, especially in Egyptian civil workers. CONCLUSIONS: Total-WFCs were associated with depression, and having low-ikigai mediated these associations in Japanese and Egyptian civil workers.

DOI： 10.2188/jea.JE20210338

Murata, Y; Uehara, K; Ogura, A; Ishigaki, S; Aiba, T; Mizuno, T; Kokuryo, T; Yokoyama, Y; Yatsuya, H; Ebata, T

SURGERY TODAY Vol. 53 ( 7 ) page： 791 - 799 2023.7

Language：English Publisher：Surgery Today

Purpose: To clarify the influence of additional internal iliac artery (IIA) resection on the loss of the gluteus muscle volume after pelvic exenteration (PE). Methods: The subjects of this retrospective analysis were 78 patients who underwent PE with or without IIA resection (n = 44 and n = 34, respectively) between 2006 and 2018. The areas of gluteal muscles (GMs) and psoas muscles (PSMs) were calculated using CT images before and 6 months after PE, and the difference was compared. Results: The volumes of the GMs and PSMs were significantly reduced after PE (P < 0.001 and P = 0.005, respectively). In the IIA resection group, the GMs were significantly reduced after surgery, but the PSMs were not. The maximum GM (Gmax) was the most atrophied among the GMs. Multivariable analysis revealed that complete IIA resection was an independent promotor of the loss of volume of the Gmax (P = 0.044). In 18 patients with unilateral IIA resection, the downsizing rate of the Gmax was significantly greater on the resected side than on the non-resected side (P = 0.008). Conclusions: The GMs and PSMs were significantly smaller after PE. Complete IIA resection reduced the Gmax area remarkably. Preservation of the superior gluteus artery is likely to help maintain Gmax size, suggesting a potential preventative measure against secondary sarcopenia.

DOI： 10.1007/s00595-022-02635-z

Predictive Value of Long-Term Systolic Blood Pressure Variability for the Development of Type 2 Diabetes Mellitus Reviewed

Yatsuya, H; Song, ZA; Hong, YJ; Mamun, R; Yoshida, Y; Akter, T; Nuamah, G; Tajima, R; Lin, JY; Al-Shoaibi, A; Chiang, C; Nakano, Y; Li, YY; Matsunaga, M; Ota, A; Tamakoshi, K

CIRCULATION Vol. 147 2023.2

Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers’ Cohort Study Reviewed

Masako Shimoda, Kayo Kaneko, Takeshi Nakagawa, Naoko Kawano, Rei Otsuka, Atsuhiko Ota, Hisao Naito, Masaaki Matsunaga, Naohiro Ichino, Hiroya Yamada, Chifa Chiang, Yoshihisa Hirakawa, Koji Tamakoshi, Atsuko Aoyama, Hiroshi Yatsuya

Journal of Epidemiology Vol. 33 ( 2 ) page： 76 - 81 2023.2

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan.Methods: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate.Results: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29.Conclusion: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.

DOI： 10.2188/jea.JE20210128

Corrigendum to "Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women" [Preventive Medicine 162 (2022) 107145]. Reviewed International journal

Yuka Kobayashi, Kazumasa Yamagishi, Isao Muraki, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

Preventive medicine Vol. 167 page： 107396 - 107396 2023.2

The Association between Adult Height and Stroke Incidence in Japanese Men and Women: A Population- Based Case- Control Study Reviewed

Yoshinobu Kondo, Hiroshi Yatsuya, Atsuhiko Ota, Shoji Matsumoto, Akihiro Ueda, Hirohisa Watanabe, Hideaki Toyoshima

Journal of Epidemiology Vol. 33 ( 1 ) page： 23 - 30 2023.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: No studies have examined the associations between adult height and ischemic stroke subtypes. METHODS: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40-79 years, and the same number of sex- and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height was also examined as a continuous variable as divided by one standard deviation of height in controls. The analyses were carried out separately for participants aged 40-59 years and 60-79 years. RESULTS: In both younger and older men, continuous height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women. CONCLUSIONS: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age-group.

DOI： 10.2188/jea.JE20200531

Including Measures of Chronic Kidney Disease to Improve Cardiovascular Risk Prediction by SCORE2 and SCORE2-OP. Reviewed International coauthorship International journal

Kunihiro Matsushita, Stephen Kaptoge, Steven Hj Hageman, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H Jafar, Simerjot K Jassal, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P Schneider, Varda Shalev, Michael G Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick An Dorresteijn, Emanuele Di Angelantonio, Frank Lj Visseren, Lisa Pennells, Josef Coresh

European journal of preventive cardiology Vol. 30 ( 1 ) page： 8 - 16 2023.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: The 2021 ESC guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, SCORE2 and SCORE2-OP, to predict CVD risk. We developed and validated an "Add-on" to incorporate CKD measures into these algorithms, using a validated approach. METHODS: In 3,054,840 participants from 34 datasets, we developed three Add-ons (eGFR only, eGFR + urinary albumin-to-creatinine ratio [ACR] [the primary Add-on], and eGFR + dipstick proteinuria) for SCORE2 and SCORE2-OP. We validated c-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997,719 participants from 34 different datasets. RESULTS: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved c-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57,485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI (e.g., 0.100 [0.062-0.138] for SCORE2) compared to the qualitative approach in the ESC guideline. CONCLUSION: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

DOI： 10.1093/eurjpc/zwac176

MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

JOURNAL OF HYPERTENSION Vol. 41 page： E134 - E134 2023.1

Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting. Reviewed International coauthorship

Abubakr Ahmed Abdullah Al-Shoaibi, Yuanying Li, Zean Song, Chifa Chiang, Yoshihisa Hirakawa, K M Saif-Ur-Rahman, Masako Shimoda, Yoshihisa Nakano, Masaaki Matsunaga, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Hiroshi Yatsuya

Journal of atherosclerosis and thrombosis Vol. 30 ( 5 ) page： 455 - 466 2023

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

AIMS: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. METHODS: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. RESULTS: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). CONCLUSION: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

DOI： 10.5551/jat.63519

Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan

Yatsuya Hiroshi

Journal of Atherosclerosis and Thrombosis Vol. 30 ( 4 ) page： 323 - 325 2023

Sociodemographic and behavioral factors related to obesity among adults in the Republic of Palau based on the WHO STEPwise approach to NCD risk factor surveillance 2011-2013: A cross-sectional study. Reviewed International coauthorship

Miyuki Hasegawa, Kaori Honjo, Chifa Chiang, Takashi Mita, Berry Moon Watson, Edolem Ikerdeu, Sherilynn Madraisau, Hiroshi Yatsuya, Atsuko Aoyama, Hiroyasu Iso

Environmental health and preventive medicine Vol. 28 ( 0 ) page： 39 - 39 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Hygiene

BACKGROUND: Pacific islanders face drastic increase of obesity-related noncommunicable disease (NCD) due to lifestyle shifts of unhealthy diets and physical inactivity. To date, however, obesity related factors have not been well elucidated in Republic of Palau. This study aimed to investigate sociodemographic and behavioral factors related to obesity using the national level data in Palau. METHODS: This is a cross-sectional, population-based study analyzing random sampling data of 2133 adults aged 25-64 years (of 20 thousand national population) from the WHO STEPwise approach to NCD risk factor surveillance (STEPS) implemented between 2011 and 2013. Sociodemographic and behavioral factors were obtained by the STEPS standardized questionnaire for NCD risk factors plus the question on betel nut chewing because of its common behavior in Micronesian countries. Logistic regression analysis was performed to estimate multivariable odds ratio (OR) of general obesity (body mass index ≥30.0 kg/m2) and central obesity (waist circumference ≥90 cm in men and ≥80 cm in women). RESULTS: Means of body mass index, prevalence of general obesity and central obesity were higher in women (29.9 kg/m2, 45.5% and 85.4%) than in men (29.3 kg/m2, 40.4% and 67.6%). After adjusted by other potential factors, native Palauan (OR 4.4, 95% CI, 2.7-7.0 for men and 3.6, 2.3-5.6 for women), betel nut chewing (1.5, 1.1-2.1 for men and 1.6, 1.2-2.3 for women), men who work at government office (1.6, 1.2-2.1), women with higher household income (1.4, 1.0-1.8) were positively associated with general obesity, while frequent vegetable intake were inversely associated with it among women (0.71, 0.54-0.93). Similar associations were observed between the aforementioned factors and central obesity. CONCLUSIONS: Native Palauan, people with betel nut chewing behavior, government employment and higher income appeared to be associated with obesity, while frequent vegetable consumption were inversely associated with obesity. Further interventions for prevention and control of obesity are necessary through the enhancing public relation activities to understand harmful health effects on betel nuts chewing and recommending domestic production of vegetables.

DOI： 10.1265/ehpm.22-00309

Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study Reviewed

Sando Masanori, Uehara Kay, Li Yuanying, Ogura Atsushi, Murata Yuki, Mizuno Takashi, Yatsuya Hiroshi, Ebata Tomoki

Journal of the Anus, Rectum and Colon Vol. 7 ( 3 ) page： 176 - 185 2023

Language：English Publisher：The Japan Society of Coloproctology

Objectives: Despite the high incidence of urinary dysfunction (UD) after rectal surgery, it remains questionable whether UD causes future chronic kidney disease (CKD). This study aimed to clarify the long-term trends in renal function and risk factors for future CKD after rectal resection.Methods: For comparison, patients who underwent rectal resection (n = 129) and colectomy (n = 127) between 2006 and 2017 were identified. The estimated glomerular filtration rate (eGFR) ratio was calculated as the ratio to the baseline. "eGFR ratio < 0.75 at 3-year" was adopted as a surrogate indicator of future CKD.Results: eGFR ratio significantly decreased in the rectal cohort compared with the colon cohort at 1.5 years (0.9 vs. 0.95, p = 0.008) and at 3 years (0.85 vs. 0.94, p < 0.001). Although the preoperative prevalence of CKD was lower in the rectal than the colon cohort (13.9% vs. 23.6%, p = 0.055), it was similar at 3 years (29.5% vs. 30.7%). In multivariate analysis, females, and cT4 were independent risk factors for future CKD, but UD itself was not.Conclusions: Postoperative eGFR significantly decreased after rectal cancer surgery compared to colectomy. The prevalence of CKD more than doubled at 3 years after rectal resection. The female sex and cT4 tumor, instead of the UD, were independent risk factors for future CKD.

DOI： 10.23922/jarc.2022-059

Psychological Distress During the Coronavirus Disease 2019 Pandemic and Associated Factors Among Undergraduate Students in Japan Reviewed

Sato, Y; Yatsuya, H; Saijo, Y; Yoshioka, E; Tabuchi, T

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS Vol. 17 ( 12 ) page： e294 2022.12

Language：English Publisher：Disaster Medicine and Public Health Preparedness

Objective: This cross-sectional study aimed to examine factors potentially associated with psychological distress among undergraduate students during the coronavirus disease 2019 pandemic in Japan. Methods: We analyzed data of 958 undergraduates (median age 20 y; 56.8% women) from a Web-based, self-administered questionnaire survey conducted from August to September 2020. Prevalence ratios (PRs) for psychological distress defined as 5 points or over of the Kessler Psychological Distress Scale (K6) were calculated by Poisson regression models. Results: The proportion of psychological distress was 40.0%. In the mutually-adjusted model, the following were significantly associated with psychological distress: decreases in household income to 50-99% of the prepandemic amount compared with no change (PR = 1.48), newly experiencing unpaid wages compared with no experience (PR = 1.44), insufficient money to buy necessities compared with no shortage (PR = 1.45), receiving a student loan or scholarship compared with none (PR = 1.27), and communication 1 to 3 times a month compared with at least once a week (PR = 1.22). In contrast, school closure during the pandemic compared with no closure was inversely associated with psychological distress (PR = 0.78). Conclusions: Among undergraduate students in Japan, economic difficulties significantly predicted psychological distress.

DOI： 10.1017/dmp.2022.245

Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan. Reviewed International journal

Chifa Chiang, Shuhei Morita, Yoshihisa Hirakawa, Farzana Tanzin Priya, Yuka Matsumoto, Atsuhiko Ota, Hiroshi Yatsuya, Takahiro Tabuchi

Scientific reports Vol. 12 ( 1 ) page： 21195 - 21195 2022.12

Language：English Publishing type：Research paper (scientific journal)

The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15-79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.

DOI： 10.1038/s41598-022-25357-1

Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study Reviewed International journal

Yasukawa S., Eguchi E., Tamakoshi A., Iso H., Tamakoshi A., Mori M., Kaneko Y., Tsuji I., Nakamura Y., Yamagishi K., Mikami H., Kurosawa M., Hoshiyama Y., Tanabe N., Tamakoshi K., Wakai K., Ando M., Suzuki K., Hashimoto S., Yatsuya H., Kikuchi S., Wada Y., Okabayashi S., Ozasa K., Mikami K., Sakata K., Kurozawa Y., Fujino Y.

BMC Women's Health Vol. 22 ( 1 ) 2022.12

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Women's Health

Background: While women’s parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women. Methods: This study followed 41,242 women aged 40–79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models. Results: During the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005). Conclusions: Nulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

DOI： 10.1186/s12905-022-01805-y

Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers' Cohort Study. Reviewed

The association of public trust with the utilization of digital contact tracing for COVID-19 in Japan. Reviewed International journal

Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota, Takahiro Tabuchi

Public health in practice (Oxford, England) Vol. 4 page： 100279 - 100279 2022.12

Language：English Publishing type：Research paper (scientific journal)

Objectives: To examin whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history of COVID-19. Study design: Cross-sectional study. Methods: Data were obtained from the Japan Society and New Tobacco Internet Survey, a nationwide online survey conducted from February to March 2021, which also assessed items related to COVID-19 and public trust. We included 453 participants with a history of COVID-19. Participants' reports of their general trust in the national government and the related policies, attitudes toward COVID-19 vaccination, and the adherence to the preventive measures against SARS-CoV-2 spread were compared between COCOA users and non-users controlling for age, sex, and socioeconomic statuses by analysis of covariance. Mediation analysis was conducted to examine whether public trust mediates the associations of certain participants' characteristics with COCOA utilization. Results: Seventy-six percent (344/453) reported the COCOA utilization. Compared to non-users, the users were younger, more likely to be men and had a tendency to have higher education. They were more willing to get COVID-19 vaccination, adherent to public health measures against the spread of the SARS-Cov-2, and more likely to express trust in government in general and policies related to COVID-19 independent of age, sex, and the socioeconomic status. Trust in government did not mediate the associations of age and education with COCOA utilization. Conclusions: The utilization of digital contact tracing technology for the health of public during pandemic was related to the degree of trust in the government in Japan.

DOI： 10.1016/j.puhip.2022.100279

Gender Difference in Fear and Anxiety about and Perceived Susceptibility to COVID-19 in the Third Wave of Pandemic among the Japanese General Population: A Nationwide Web-Based Cross-Sectional Survey. Reviewed International journal

Rio Sasaki, Atsuhiko Ota, Hiroshi Yatsuya, Takahiro Tabuchi

International journal of environmental research and public health Vol. 19 ( 23 ) 2022.12

Language：English Publishing type：Research paper (scientific journal)

Existing research suggested gender differences in fear and anxiety about and perceived susceptibility to COVID-19 and previous infectious disease pandemics. We analyzed whether women felt fear and anxiety about and perceived susceptibility to COVID-19 more frequently than men in Japan. We conducted a cross-sectional analysis using internet survey data collected during the third wave of the pandemic in Japan. The subjects were enrolled from the Japanese general population: 11,957 men and 11,559 women. Fear and anxiety specifically related to COVID-19 were evaluated with the Japanese version of the Fear of COVID-19 Scale (FoCS). The question "How likely do you think you will be infected with COVID-19?" was used to assess the perceived susceptibility to COVID-19. Women had higher mean (standard deviation) FoCS scores [18.6 (5.6) vs. 17.5 (5.9), d = 0.190] and reported the median or higher FoCS score (57.4% vs. 51.4%, φ = 0.060) and perceived susceptibility (13.6% vs. 11.5%, φ = 0.032) more frequently than men. The odds ratios (95% confidence intervals) adjusted for age, having a spouse, comorbidities, watching commercial TV stations' news programs, employment status, and household income were 1.24 (1.17-1.32) and 1.27 (1.16-1.38), respectively. We observed that women were more anxious and fearful about and perceived the susceptibility to infectious diseases more frequently than men even one year after the pandemic occurred in Japan, although the effect size was small.

DOI： 10.3390/ijerph192316239

Motoi Terabe, Tsuyoshi Kitajima, Atsuhiko Ota, Hiroshi Yatsuya, Nakao Iwata

Fujita medical journal Vol. 8 ( 4 ) page： 103 - 107 2022.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Fujita Medical Society

OBJECTIVES: The influence of habitual alcohol consumption on insomnia symptoms in healthy workers remains unclear. In this study, we evaluated the association between habitual alcohol consumption among civil servants and insomnia symptoms such as difficulty falling asleep, difficulty staying asleep, and tiredness after sleep, using longitudinal data. METHODS: We enrolled civil servants in a prospective cohort study who completed questionnaires at baseline. Of those, 2861 participants were revaluated in a 5-year follow-up survey. Insomnia symptoms during the past month were assessed using self-reporting. Alcohol drinking habits were assessed by querying the frequency of drinking alcohol as well as the amount of alcohol usually consumed per one occasion. RESULTS: Drinking alcohol every day was less likely to have difficulty falling asleep (odds ratio, 0.42 95% confidence interval, 0.20-0.89), and drinking alcohol 3 or more days a week was associated with difficulty staying asleep (odds ratio, 1.48; 95% confidence interval, 1.16-1.90). CONCLUSIONS: Drinking alcohol every day may produce subjective improvement in sleep onset. However, drinking alcohol 3 or more days a week may increase arousal during sleep, which contributes to reduced sleep quality. These results suggest the possibility that long-term daily habitual drinking may reinforce a sense of improvement in subjective sleep onset but may possibly induce sleep disturbance.

DOI： 10.20407/fmj.2021-015

Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers’ Cohort Study Reviewed International coauthorship International journal

Zean Song, Yupeng He, Chifa Chiang, Abubakr A. A. Al-shoaibi, K. M. Saif-Ur-Rahman, Md Razib Mamun, Atsuko Aoyama, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Yuanying Li, Hiroshi Yatsuya

Hypertension Research Vol. 45 ( 11 ) page： 1772 - 1780 2022.11

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s41440-022-00993-2

Other Link： https://www.nature.com/articles/s41440-022-00993-2

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study. Reviewed International journal

Tamie Nakajima, Hailan Wang, Yuan Yuan, Yuki Ito, Hisao Naito, Yoshiyuki Kawamoto, Kozue Takeda, Kiyoshi Sakai, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hiroshi Yatsuya, Michihiro Kamijima

Archives of toxicology Vol. 96 ( 10 ) page： 2785 - 2797 2022.10

Language：English Publishing type：Research paper (scientific journal)

Occupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. A case-control study of 80 TCE-HS patients, 186 TCE-tolerant controls (TCE-TC), and 71 TCE-nonexposed controls (TCE-nonEC) was conducted to measure their serum anti-CYP2E1 antibody (IgG) levels. The effects of TCE exposure indices, such as 8-h time-weighted-average (TWA) airborne concentrations, urinary metabolite concentrations, and TCE usage duration; sex; smoking and drinking habits; and alanine aminotransferase (ALT) levels on the antibody levels were also analyzed in the two control groups. There were significant differences in anti-CYP2E1 antibody levels among the three groups: TCE-TC > TCE-HS patients > TCE-nonEC. Antibody levels were not different between HLA-B*13:01 carriers and noncarriers in TCE-HS patients and TCE-TC. The serum CYP2E1 measurement suggested increased immunocomplex levels only in patients with TCE-HS. Multiple regression analysis for the two control groups showed that the antibody levels were significantly higher by the TCE exposure. Women had higher antibody levels than men; however, smoking, drinking, and ALT levels did not affect the anti-CYP2E1 antibody levels. Anti-CYP2E1 antibodies were elevated at concentrations lower than the TWA concentration of 2.5 ppm for TCE exposure. Since HLA-B*13:01 polymorphism was not involved in the autoantibody levels, the possible mechanism underlying the pathogenesis of TCE-HS is that TCE exposure induces anti-CYP2E1 autoantibody production, and HLA-B*13:01 is involved in the development of TCE-HS.

DOI： 10.1007/s00204-022-03326-x

Association between irregular daily routine and risk of incident stroke and coronary heart disease in a large Japanese population. Reviewed International journal

Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

Scientific reports Vol. 12 ( 1 ) page： 15750 - 15750 2022.9

Language：English Publishing type：Research paper (scientific journal)

Circadian misalignments have been linked to adverse cardiometabolic outcomes. However, the association between irregular daily routine and the risk of cardiovascular disease (CVD) remains unknown. We examined this association in a prospective study in Japan. The study included 78,115 Japanese participants aged 45-74 years. The self-reported daily routine was evaluated using the question, 'Is your daily routine or activity schedule regular?' The response (yes/no) was obtained as a binary variable. Cox proportional hazard regression analysis was used to estimate the hazard ratios and 95% confidence intervals for the association between an irregular daily routine and CVD incidence risk. Among the participants, 23.7% reported an irregular daily routine. During the mean follow-up period of 13.3 years, we observed 4641 CVD events. An irregular daily routine was significantly associated with increased risks of CVD and total stroke in women, but not in men. This positive association between an irregular daily routine and the risk of CVD was weak in the high vegetable and fruit consuming population. An irregular daily routine is positively associated with the risk of incident CVD, especially in women. These associations may be weak in populations that consume a diet rich in vegetables and fruits.

DOI： 10.1038/s41598-022-20019-8

Diabetes management in people living with dementia in Japan: a qualitative exploration Reviewed International journal

KM, SUR; HIRANO, Y; HIRAKAWA, Y; YATSUYA, H

PSYCHOGERIATRICS Vol. 22 ( 5 ) page： 728 - 735 2022.9

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Psychogeriatrics

Background: Dementia and diabetes are highly prevalent among the older society in Japan. People living with dementia (PLWD) often face hurdles in managing diabetes. This study explored the perspectives of healthcare providers in Japan regarding diabetes management in PLWD. Methods: We conducted a qualitative study using in-depth interviews as a data collection method. A total of 15 physicians and nurses were interviewed. A qualitative content analysis of the codes was performed to generate the themes. Results: The major themes focused on the management of medications/therapeutic regimen, difficulties of continuing health care, emotional aspects of PLWD for adherence to lifestyle modification, and varying direction and degree of family support for diabetes care. Conclusion: PLWD in Japan face challenges in medication management, food restriction, and lifestyle modification. Policies to engage home visit care workers in medication management, consideration of the emotional aspect of PLWD, and utilisation of social support might help in the proper management of diabetes in PLWD.

DOI： 10.1111/psyg.12876

Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women. Reviewed International journal

Yuka Kobayashi, Kazumasa Yamagishi, Isao Muraki, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

Preventive medicine Vol. 162 page： 107145 - 107145 2022.9

Language：English Publishing type：Research paper (scientific journal)

The prospective association between secondhand smoke (SHS) and the risk of incident cardiovascular disease (CVD) remains unclear. This study was the first to examine the association between SHS and risks of ischemic heart disease (IHD), stroke, and total CVD in a large cohort in Asia. The study followed 24,232 never-smoking women aged 40-59 from around Japan (Akita, Iwate, Nagano, Niigata, Ibaraki, Kochi, Nagasaki, and Okinawa prefectures). Their husbands were classified into never, former, and current smokers. After adjustment for age, body mass index, alcohol consumption, histories of hypertension and diabetes mellitus, medication use for hyperlipidemia, menopausal status, and public health center areas, the hazard ratios (HRs) of CVD according to husbands' smoking status were estimated by Cox proportional hazards models. During the 440,360 person-years follow-up, 846 women had total CVDs (103 IHDs, 744 strokes). The proportional hazard assumption was not assured during the total follow-up from 1990 to 2012, but so was then the follow-up of < and ≥ 10 person-years were examined separately. The multivariable HRs (95% confidence intervals) associated with husbands' current versus non-current smoking was 2.02 (1.19-3.45) for IHD, 1.18 (0.98-1.42) for stroke, and 1.25 (1.05-1.49) for total CVD in the follow-up of ≥10 person-years. The SHS from husbands may raise the risk of IHD among middle-aged never-smoking women.

DOI： 10.1016/j.ypmed.2022.107145

Impact of the COVID-19 pandemic on national and prefectural health and nutrition examination surveys: A report by the Monitoring Report Committee of the Japanese Society of Public Health Reviewed

母体特性と妊娠中期血清n3系多価不飽和脂肪酸濃度の関連

金子佳世, 伊藤由起, 加藤沙耶香, 榎原毅, 八谷寛, 上島通浩

日本公衆衛生学会総会抄録集 Vol. 81回 page： 207 - 207 2022.9

A comparative study of the work-family conflicts prevalence, their sociodemographic, family, and work attributes, and their relation to the self-reported health status in Japanese and Egyptian civil workers Reviewed International coauthorship International journal

Omnyh Kamal Abd El Latief, Ehab Salah Eshak, Eman Mohamed Mahfouz, Hiroyasu Iso, Hiroshi Yatsuya, Eman Mohamed Sameh, Eman Ramadan Ghazawy, Sachiko Baba, Shimaa Anwer Emam, Ayman Soliman El-khateeb, Ebtesam Esmail Hassan

BMC Public Health Vol. 22 ( 1 ) page： 1490 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Cross-cultural studies studying work-family conflicts (W_F_Cs) are scarce. We compared the prevalence of W_F_Cs, factors correlated with them, and their association with self-rated health between Japan and Egypt.

Methods

Among 4862 Japanese and 3111 Egyptian civil workers recruited by a convenience sample in 2018/2019 and reported self-rated health status, we assessed the W_F_Cs by the Midlife Development in the US (MIDUS) and attributed them to sociodemographic, family, and work variables. We also evaluated the W_F_Cs’ gender- and country-specific associations with self-rated health by logistic regression analyses.

Results

W_F_Cs were more prevalent in Egyptian than in Japanese women (23.7% vs. 18.2%) and men (19.1% vs. 10.5%), while poor self-rated health was more prevalent in Japanese than Egyptians (19.3% and 17.3% vs. 16.9% and 5.5%). Longer working hours, shift work, and overtime work were positively associated with stronger work-to-family conflict (WFC). Whereas being single was inversely associated with stronger family-to-work conflict (FWC). Living with children, fathers, or alone in Japan while education in Egypt was associated with these conflicts. The OR (95% CI) for poor self-reported health among those with the strong, in reference to weak total W_F_Cs, was 4.28 (2.91–6.30) and 6.01 (4.50–8.01) in Japanese women and men and was 2.46 (1.75–3.47) and 3.11 (1.67–5.80) in Egyptian women and men.

Conclusions

Japanese and Egyptian civil workers have different prevalence and correlated factors of W_F_Cs and self-rated health. W_F_Cs were associated in a dose–response pattern with poor-self-rated health of civil workers in both countries.

DOI： 10.1186/s12889-022-13924-0

Other Link： https://link.springer.com/article/10.1186/s12889-022-13924-0/fulltext.html

KUBO Akiko, KUNO Kazue, MARUYAMA Koutatsu, TSUKINOKI Rumi, NODA Hiroyuki, EGAWA Ken'ichi, SHIBUYA Izumi, SEI Masako, CHIHARA Mieko, NISHINA Kazue, YATSUYA Hiroshi

Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) Vol. 69 ( 8 ) page： 586 - 594 2022.8

Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers’ Cohort Study Reviewed International journal

Yuanying Li, Hiroshi Yatsuya, Chaochen Wang, Mayu Uemura, Masaaki Matsunaga, Yupeng He, Maythet Khine, Atsuhiko Ota

Nutrients Vol. 14 ( 15 ) page： 3019 - 3019 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The aim of the present study was to derive dietary patterns to explain variation in a set of nutrient intakes or in the measurements of waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) and to prospectively investigate these patterns in relation to the risk of developing metabolic syndrome (MetS) and its components during the follow-up. The study participants were comprised of 2944 government employees aged 30–59 years without MetS. RRR was applied with 38 food groups as predictors and with two sets of response variables. The first set included intake of putatively beneficial nutrients, and the first factor retained was named the Healthy Dietary Pattern (HDP). The second one included baseline WC and FBG, and the first factor was named the Unhealthy Dietary Pattern (UHDP). Multivariable Cox proportional hazard model was used to estimate hazard ratio and 95% confidence intervals with adjustments for age, sex, total energy consumption and other potential confounders. During the 5-year median follow-up, we ascertained 374 cases of MetS. The HDP score was inversely associated with the incidence of MetS (p-trend = 0.009) and hypertension (p-trend = 0.002) and marginally significantly associated with elevated triglyceride and decreased high-density lipoprotein cholesterol (p-trend = 0.08). The UHDP score was linearly positively associated with the incidence of MetS and all its components (all p-trend < 0.05). Both the HDP and UHDP predicted the development of MetS and its components.

DOI： 10.3390/nu14153019

Combined Exoscopic and Endoscopic Two-Step Keyhole Approach for Intracranial Meningiomas Reviewed International journal

Tadashi Watanabe, Kenichiro Iwami, Yugo Kishida, Tetsuya Nagatani, Hiroshi Yatsuya, Shigeru Miyachi

Current Oncology Vol. 29 ( 8 ) page： 5370 - 5382 2022.8

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The advantages of neuroendoscopic surgery are the wide viewing angle and the freedom of an axis of view with minimal surgical trauma. With the advent of the exoscope, which has similar advantages to endoscopy, such as a small body and ergonomically superior heads-up surgery, it has become possible to add a field of view that is similar to that of microsurgery to endoscopic surgery. By taking advantage of the features of these scopes, we report the usefulness of the minimally invasive combined exoscopic and endoscopic two-step keyhole approach (EEKA) for various types of meningiomas. We reviewed data from 34 consecutive cases of EEKA for various types of intracranial meningiomas compared with that of conventional microsurgery. All of the tumors were resected as planned without severe complications. Significantly better outcome data were obtained in terms of the blood loss and the surgical time in the EEKA group, in addition to the craniotomy size. The well-illuminated fine vision in the deep corners by the endoscope enabled radical resection of the tumors with minimum burden on the patients. This technique has the potential for minimally invasive surgery in intracranial meningioma patients, including the older population.

DOI： 10.3390/curroncol29080426

Influence of the COVID-19 pandemic on regular clinic visits and medication prescriptions among people with diabetes: Retrospective cohort analysis of health care claims. Reviewed International journal

Toshiki Maeda, Takumi Nishi, Masataka Harada, Kozo Tanno, Naoyuki Nishiya, Kei Asayama, Nagako Okuda, Daisuke Sugiyama, Hiroshi Yatsuya, Akira Okayama, Hisatomi Arima

Medicine Vol. 101 ( 29 ) page： e29458 2022.7

Language：English Publishing type：Research paper (scientific journal)

The aim of this study was to investigate the effect of the COVID-19 pandemic on regular clinic visits among people with diabetes and to elucidate the factors related to visit patterns among these patients during the pandemic. This was a longitudinal study using anonymized insurance claims data from the Joint Health Insurance Society in Tokyo from October 2017 to September 2020. First, we identified patients with diabetes who were fully enrolled in the health plan from fiscal year 2017 until September 2020 and who were regularly receiving glucose-lowering medications (every 1-3 months) from October 2017 to September 2018. We divided follow-up into the pre-pandemic period (October 2018 to March 2020) and the pandemic period (April 2020 to September 2020). A multilevel logistic regression model was used to determine the risks of delayed clinic visits/medication prescriptions (i.e., >3 months after a previous visit/prescription) during the pandemic period. We identified 1118 study participants. The number of delayed clinic visits/medication prescriptions during the pre-pandemic and pandemic periods was 188/3354 (5.6%) and 125/1118 (11.2%), respectively. There was a significant increase in delayed clinic visits during the pandemic (adjusted odds ratio 3.68 (95% confidence interval 2.24 to 6.04, P < .001), even after controlling for confounding factors. We also found a significant interaction between sex and delayed visits; women had significantly fewer clinic visits during the COVID-19 pandemic than men. We clarified the relationship of the COVID-19 pandemic with delays in regular clinic visits and medication prescriptions among people with diabetes. The response to the COVID-19 pandemic differed between men and women.

DOI： 10.1097/MD.0000000000029458

High Maternal Total Cholesterol Is Associated With No-Catch-up Growth in Full-Term SGA Infants: The Japan Environment and Children's Study. Reviewed International journal

Kayo Kaneko, Yuki Ito, Takeshi Ebara, Sayaka Kato, Taro Matsuki, Hazuki Tamada, Hirotaka Sato, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Hiroshi Yatsuya, Michihiro Kamijima

Frontiers in endocrinology Vol. 13 page： 939366 - 939366 2022.7

Language：English Publishing type：Research paper (scientific journal)

Objectives: Infants born small for gestational age (SGA) with no catch-up growth (No-CU) are at high risk of intellectual and developmental disabilities. However, factors leading to No-CU among SGA infants are unclear. This study aimed to examine the association between maternal total cholesterol (TC) in mid-pregnancy and No-CU at 3 years among full-term SGA infants. Study Design: The Japan Environment and Children's Study (JECS) is a nationwide prospective birth cohort study. We extracted a total of 2,222 mothers and full-term SGA infants (length and/or weight <-2 standard deviation [SD]) without congenital abnormalities from the original JECS cohort comprising a total of 104,062 fetal records. According to the distribution of maternal TC in the entire cohort, participants were classified into nine groups per each fifth percentile with the 20th-79th percentiles (204-260 mg/dl) as the reference group. No-CU was defined by a Z-score of height at 3 years <-2 SD according to the growth standard charts for Japanese children. Multivariable-adjusted logistic regression models were carried out using multiple imputations. Additionally, a multiple-adjusted restricted cubic spline model was performed in the complete dataset. Results: A total of 362 (16.3%) children were No-CU at 3 years. After adjusting for the Z-score of birth weight, age of mother, smoking status, weight gain during pregnancy, breastfeeding and meal frequency at 2 years, and parents' heights, the odds ratio (95% confidence intervals) of No-CU was 2.95 (1.28-6.80) for children whose maternal TC levels were in the highest category (≥294 mg/dl), compared to the reference group. A multiple-adjusted restricted cubic spline model showed a non-linear trend of the significant association between high maternal TC and No-CU (p for linear trend = 0.05, p for quadratic trend <0.05). Conclusion: High maternal TC at mid-pregnancy was associated with No-CU among SGA infants. Such infants should be carefully followed up to introduce appropriate growth hormonal treatment. The findings may support previous animal experimental studies which indicated that maternal high-fat diet exposure induces impairment of growth and skeletal muscle development in the offspring. Future studies are required to elucidate the detailed mechanism.

DOI： 10.3389/fendo.2022.939366

Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma Reviewed International journal

Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

BMC GASTROENTEROLOGY Vol. 22 ( 1 ) page： 329 2022.7

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Gastroenterology

Background: The pathological evaluation of tissues with cholangitis is considered difficult, which can often occur after endoscopic sphincterotomy (EST) and endoscopic biliary stenting (EBS). This study aimed to evaluate the influence of a history of EST and EBS on the sensitivity of transpapillary forceps bile duct biopsy (TB) for bile duct adenocarcinoma. Methods: This retrospective study included consecutive cases of bile duct adenocarcinoma in which TB was performed before July 2020 until the number exceeded that required to support statistical and noninferiority analyses of the sensitivity of TB between patients with and without each variable. The incidence of postprocedural adverse events related to each factor was also investigated. Results: Overall, 280 samples were required in each group, and 437 subjects (792 samples) were included. The sensitivity of TB was 63.6% for the subjects and 59.6% for the biopsy samples. For the biopsy samples, the sensitivity did not differ significantly between samples from patients with and without a history of EST (59.1% vs. 58.9%, P = 0.952) and EBS (62.1% vs. 55.4%, P = 0.065). The sensitivity was significantly higher for samples from patients with jaundice (67.9% vs. 57.0%, P = 0.008). There were significantly fewer procedure-related adverse events in patients with a history of EST (10.8% vs. 19.0%, P = 0.017) and EBS (12.0% vs. 21.7%, P = 0.005). Conclusions: A history of EST or EBS did not influence sensitivity of TB but significantly decreased the incidence of adverse events. To safely and reliably perform TB to diagnose bile duct adenocarcinoma, planning, including for EST and EBS, is necessary.

DOI： 10.1186/s12876-022-02402-x

Early impact of the spread of the novel coronavirus infection on medical, long-term care and welfare sites in Japan: A qualitative study Reviewed

Tokai Journal of Public Health Vol. 10 ( 1 ) page： 85 - 94 2022.7

Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Tokai Public Health Association

ObjectivesThis study aimed to describe the structure of problems that occurred in the field of medical, long-term care and welfare under the unprecedented situation of the early stage of the spread of novel coronavirus.MethodsWe conducted the online interview from April to May in 2020, targeting 27 workers on medical, long-term care, and welfare sites. The semi-structured interview using an interview guide was conducted in a free-answer format. A verbatim record was created from the recorded interview content, and the text data was analyzed by qualitative content analysis.ResultsWe extracted 126 types of the meaning unit and the following four themes. (1) anxiety and dissatisfaction with information deficiency and insufficient information sharing, (2) stress of medical workers due to the double burden of overwork and discrimination from society, (3) the measures against loneliness and poverty, and (4) difficulty in infection prevention measures.ConclusionUnder the unprecedented situation in the early stage of novel coronavirus infection, shortages of highly reliable information as well as of medical materials were particularly serious. Preventive measures against stress for medical staff and the livelihood support for loneliness and poverty were found to be important.

DOI： 10.24802/tpha.2022-02

健診で血圧高値を指摘された高血圧症患者の疾患と治療に対する認識と態度 Reviewed

洪英在, 平川仁尚, 犬飼麻里子, 水野晴子, 江啓発, 八谷寛

東海公衆衛生雑誌 Vol. 10 ( 1 ) page： 180 - 186 2022.7

Authorship：Last author Language：Japanese Publisher：東海公衆衛生学会

目的　適切に血圧がコントロールされている人を増やすためには, コントロール不良の高血圧症患者に焦点を当て, その要因を明らかにする必要がある。高血圧症は無症候性であることが多いため, 患者本人の疾患や治療に関する認識への働きかけを行うことが重要であるが, そうした研究は少ない。本研究は, 健診でII度以上の血圧高値を指摘された高血圧患者 (すなわち, 良好なコントロール状態にあるとは判断されない高血圧症患者) の疾患と治療に対する認識や態度を探索することを目的とした。方法　対象者は, 愛知県岩倉市が2019年度, 2020年度, 2021年度に実施した特定健診受診者の中から, 一度でも収縮期血圧160mmHg以上または拡張期血圧100mmHg以上であった300名に対して研究参加を呼び掛け, 同意が得られた13名とした。データ収集は1回約30分間の1対1の半構造化面接により行われた。データ分析は, 質的内容分析により行われた。結果　対象者の性別は女性5名, 平均年齢は69.2歳 (60-74歳) であった。2名がBMI 25kg/m2以上の肥満であったがBMI 35kg/m2以上の高度肥満は存在しなかった。13名ともに高血圧症での医療機関通院歴を有し, 8名がかかりつけ医から降圧剤を処方されていた。質的分析の結果, 高血圧に対するイメージ, 治療に関する認識, ピアから受ける影響, 患者からみたかかりつけ医の診療姿勢, 実際に行動変容することの難しさ, の5テーマが抽出された。対象者の中には, 高血圧症に対して重大性を認識していないか, 生活習慣改善に向けて行動を起こすメリットを感じていないようであった。また, 降圧剤について, 必要性を感じず, 副作用を危惧していた。こうした認識は, ピア, つまり同じ疾患を持つ家族・同僚や, かかりつけ医の診療姿勢から影響を受けていた。結論　コントロールが良好でない可能性がある高血圧症患者の疾患と治療に対する認識と態度として, 行動変容の準備性の低さ, 治療内容に関する否定的な認識, ピアからの影響の大きさ, かかりつけ医の診療姿勢への転嫁的態度が存在する可能性があると考えられた。

DOI： 10.24802/tpha.2022-13

特定健診およびレセプトデータを用いた愛知県岩倉市における心血管疾患発症リスクおよび人口寄与危険割合に関するコホート研究 Reviewed

江啓発, 藤社紗梨, 水野晴子, 平川仁尚, 八谷寛

東海公衆衛生雑誌 Vol. 10 ( 1 ) page： 166 - 179 2022.7

Authorship：Last author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：東海公衆衛生学会

目的　特定健診とレセプトの分析に基づき保健事業の効果や効率を高めていくこと (データヘルス計画) が保険者には求められているが、課題設定や被保険者への情報提供に資する実態把握には特定健診受診率や有所見者割合、高額医療費者数等の横断的な検討が中心である。そこで本研究は、愛知県岩倉市国民健康保険 (国保) 加入者の特定健診とその後の経年的なレセプト情報を突合したコホート研究データを用い、心血管疾患発症リスクおよび人口寄与危険割合の推定を試みた。方法　岩倉市国保加入者のうち、2013年から2018年までの5年間に特定健診を1回以上受診した者を対象とし、最初の受診年をベースラインとした。ベースライン以前に心血管疾患の既往歴のある者および問診データに欠損値の多い者を除外した6,496名 (男性2,722名、女性3,774名) を解析対象とした。レセプト情報を用いて追跡期間中の心血管疾患の発症を把握し、特定健診結果から把握した危険因子と全心血管疾患、心筋梗塞、脳卒中の関連を性・年齢および危険因子を相互に調整したCox比例ハザードモデルで検討した。また、多変量調整ハザード比(HR)と発症者における危険因子の割合から人口寄与危険割合を推定した。結果　解析対象者のベースライン時平均年齢は62.5歳であった。追跡期間中の全心血管疾患、心筋梗塞、脳卒中の発症者数はそれぞれ149名、58名、91名であった。女性に比し男性 (HR : 2.0、95%信頼区間 (CI) : 1.4-2.8)、非現喫煙者に比し現喫煙者 (HR : 1.7、95% CI : 1.1-2.5) は心血管疾患発症リスクが約2倍高かった。非高血圧に比しI度およびII度以上高血圧の心血管疾患発症のハザード比はそれぞれ1.7 (95% CI : 1.1-2.4)、2.3 (95% CI : 1.5-3.5) であった。また、糖尿病 (HR : 2.3、95% CI : 1.4-3.9)、メタボリックシンドローム該当者 (HR : 1.6、95% CI : 1.1-2.3) ともに約2倍の心血管疾患発症リスクと関連した。心血管疾患の人口寄与危険割合は高血圧 (I度以上) で27.2%と最も高く、次いで喫煙11.3% メタボリックシンドローム10.5%、糖尿病10.2%であった。結論　高血圧、喫煙、糖尿病、メタボリックシンドロームは性、年齢、その他の危険因子に独立して心血管疾患発症リスク上昇と有意に関連した。心血管疾患の人口寄与危険割合は高血圧で最も高かった。

DOI： 10.24802/tpha.2022-12

Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort Reviewed

Suzuki S., Katagiri R., Yamaji T., Sawada N., Imatoh T., Ihira H., Inoue M., Tsugane S., Iwasaki M., Miyamoto Y., Abe S.K., Tanaka S., Moriya T., Minamizono T., Shirai Y., Kuniyoshi H., Yoshimi T., Sonoda H., Tagami T., Ando T., Kimura T., Kokubo Y., Yamagishi K., Mizoue T., Nakamura K., Takachi R., Ishihara J., Iso H., Kitamura T., Saito I., Yasuda N., Mimura M., Sakata K., Noda M., Goto A., Yatsuya H.

British Journal of Cancer Vol. 126 ( 10 ) page： 1481 - 1489 2022.6

Language：English Publisher：British Journal of Cancer

Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (Ptrend < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.

DOI： 10.1038/s41416-022-01715-8

Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole. Reviewed

Noriaki Ohara, Kay Uehara, Atsushi Ogura, Masanori Sando, Toshisada Aiba, Yuki Murata, Takashi Mizuno, Kokuryo Toshio, Yukihiro Yokoyama, Satoko Ishigaki, Yuanying Li, Hiroshi Yatsuya, Tomoki Ebata

Surgery today Vol. 52 ( 6 ) page： 953 - 963 2022.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. METHODS: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. RESULTS: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. CONCLUSION: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The "fighting over the fascia" theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

DOI： 10.1007/s00595-021-02434-y

Prioritization and sequential exclusion of articles in systematic reviews Reviewed International coauthorship International journal

Saif-Ur-Rahman, KM; Hasan, M; Hossain, S; Anwar, I; Hirakawa, Y; Yatsuya, H

CAMPBELL SYSTEMATIC REVIEWS Vol. 18 ( 2 ) page： e1229 2022.6

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Campbell Systematic Reviews

It is difficult to match the causes of exclusion among two independent review authors after screening the title and abstract or full texts in systematic reviews. We have proposed the prioritization and sequential exclusion approach to reduce the subjectivity in reporting reasons for exclusion. This approach might reduce the burden of mismatched numbers while describing the cause of exclusion.

DOI： 10.1002/cl2.1229

Implementation strategies for the patient safety reporting system using Consolidated Framework for Implementation Research: a retrospective mixed-method analysis Reviewed

Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

BMC HEALTH SERVICES RESEARCH Vol. 22 ( 1 ) page： 409 2022.3

Language：English Publisher：BMC Health Services Research

Background: Healthcare-related adverse events occur because of complex healthcare systems. The patient safety reporting system is a core component of patient safety initiatives in hospitals. However, hospital management often encounters a cultural barrier with its implementation and struggles to overcome the same. Implementation science would be useful for analysing implementation strategies. This study determines the effects of the implemented strategy on an increase in the number of patient safety reports and the determinants of successful implementation, using the implementation framework. Methods: Mixed method analysis was performed in Fujita Health University Hospital (FHUH), a large volume hospital in Japan. We identified strategies to implement the patient safety reporting system by scrutinising internal documents using the Consolidated Framework for Implementation Research (CFIR). The electronic reporting systems developed in 2004 in the FHUH and the number of reports were analysed using the staff data and hospital volumes. Results: Reports (n = 110,058) issued between April 2004 and March 2020 were analysed. The number of reports increased from 2004 to 2008 and from 2013 to 2019, reaching 14,037 reports per year. Between 2009 and 2012, the FHUH experienced a stagnation period where the number of reports were not increasing. From the qualitative materials, we identified 74 strategies which contributed to the implementation of the patient safety reporting system. Among these, the domain of ‘intervention characteristics’ in the CFIR contained 12 strategies, ‘outer settings’ contained 20, ‘inner settings’ contained 21, ‘characteristics of individuals’ contained 8, and ‘process’ contained 13. There were two concentrated periods of the implemented strategies, the number was 17 in 2007 and 10 in 2016. These concentrated periods preceded a remarkable increase in the number of patient safety reports. Conclusions: A safety culture had been fostered in FHUH in the study period. A relationship between number of strategies and development of a reporting culture was observed. The intensity of adequate strategies was needed for implementation of patient safety reporting system. Therefore, the implementation framework is useful for analysing patient safety initiatives for safety culture.

DOI： 10.1186/s12913-022-07822-9

Low Density Lipoprotein Cholesterol Associations With The Risk Of Coronary Heart Disease And Stroke Among Middle-aged Japanese Workers: Analysis Using Inverse Probability Weighting

Al-shoaibi, AA; Li, YY; Chiang, C; Hirakawa, Y; Song, Z; Saif-Ur-Rahman, KM; Masako, S; Masaaki, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

CIRCULATION Vol. 145 2022.3

Smoking cessation, weight gain and risk of cardiovascular disease. Reviewed International journal

Xiaowen Wang, Jia-Yi Dong, Renzhe Cui, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

Heart (British Cardiac Society) Vol. 108 ( 5 ) page： 375 - 381 2022.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain. METHODS: A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5.0 kg, >5.0 kg), long-term quitters and never smokers. Quitting smoking within and longer than 5 years were defined as recent and long-term quitters, respectively. We used Cox proportional hazard models to estimate the HR for incident CVD, coronary heart disease (CHD) and stroke. RESULTS: We identified 4023 CVDs (889 CHDs and 3217 strokes) during a median of 14.8 years of follow-up. Compared with sustained smokers, the multivariable HR (95% CI) for CVD was 0.66 (0.52 to 0.83) for recent quitters without weight gain, 0.71 (0.55 to 0.90) for recent quitters with weight gain of 0.1-5.0 kg, 0.70 (0.44 to 1.10) for recent quitters with weight gain of >5.0 kg, 0.56 (0.49 to 0.64) for long-term quitters, and 0.60 (0.55 to 0.66) for never smokers. The analysis restricted to men showed a similar association. Prespecified analysis by age suggested that recent quitters overall had a lower HR for CVD among those aged <60 years vs ≥60 years. Similar patterns of association were observed in CHD and stroke. CONCLUSIONS: Postcessation weight gain did not attenuate the protective association between smoking cessation and risk of CVD.

DOI： 10.1136/heartjnl-2021-318972

職業性ストレスと退職後の認知機能低下に関する縦断的研究愛知職域コホート研究

中島啓裕, 江啓発, 平川仁尚, He Yupeng, 霜田真子, 玉腰浩司, 八谷寛

産業ストレス研究 Vol. 29 ( 1 ) page： 169 - 169 2022.3

Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 Reviewed International coauthorship

Cousin, E; Duncan, BB; Stein, C; Ong, KL; Vos, T; Abbafati, C; Abbasi-Kangevari, M; Abdelmasseh, M; Abdoli, A; Abd-Rabu, R; Abolhassani, H; Abu-Gharbieh, E; Accrombessi, MMK; Adnani, QES; Afzal, MS; Agarwal, G; Agrawaal, KK; Agudelo-Botero, M; Ahinkorah, BO; Ahmad, S; Ahmad, T; Ahmadi, K; Ahmadi, S; Ahmadi, A; Ahmed, A; Salih, YA; Akande-Sholabi, W; Akram, T; Al Hamad, H; Al-Aly, Z; Alcalde-Rabanal, JE; Alipour, V; Aljunid, SM; Al-Raddadi, RM; Alvis-Guzman, N; Amini, S; Ancuceanu, R; Andrei, T; Andrei, CL; Anjana, RM; Ansar, A; Antonazzo, IC; Antony, B; Anyasodor, AE; Arabloo, J; Arizmendi, D; Armocida, B; Artamonov, AA; Arulappan, J; Aryan, Z; Asgari, S; Ashraf, T; Astell-Burt, T; Atorkey, P; Atout, MMW; Ayanore, MA; Badiye, AD; Baig, AA; Bairwa, M; Baker, JL; Baltatu, OC; Banik, PC; Barnett, A; Barone, MTU; Barone-Adesi, F; Barrow, A; Bedi, N; Belete, R; Belgaumi, UI; Bell, AW; Bennett, DA; Bensenor, IM; Beran, D; Bhagavathula, AS; Bhaskar, S; Bhattacharyya, K; Bhojaraja, VS; Bijani, A; Bikbov, B; Birara, S; Bodolica, V; Bonny, A; Brenner, H; Briko, NI; Butt, ZA; dos Santos, FLC; Camera, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Cerin, E; Chakraborty, PA; Chandan, JS; Chattu, VK; Chen, SM; Choi, JYJ; Choudhari, SG; Chowdhury, EK; Chu, DT; Corso, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, L; Dandona, R; Dávila-Cervantes, CA; De Neve, JW; Denova-Gutiérrez, E; Dhamnetiya, D; Diaz, D; Ebtehaj, S; Edinur, HA; Eftekharzadeh, S; El Sayed, I; Elgendy, IY; Elhadi, M; Elmonem, MA; Faisaluddin, M; Farooque, U; Feng, XQ; Fernandes, E; Fischer, F; Flood, D; Freitas, M; Gaal, PA; Gad, MM; Gaewkhiew, P; Getacher, L; Ghafourifard, M; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Gill, PS; Ginawi, IA; Glushkova, EV; Golechha, M; Gopalani, SV; Guimaraes, RA; Das Gupta, R; Gupta, R; Gupta, VK; Gupta, VB; Gupta, S; Habtewold, TD; Hafezi-Nejad, N; Halwani, R; Hanif, A; Hankey, GJ; Haque, S; Hasaballah, AI; Hasan, SS; Hashi, A; Hassanipour, S; Hay, SI; Hayat, K; Heidari, M; Hossain, MBH; Hossain, S; Hosseini, M; Hoveidamanesh, S; Huang, JJ; Humayun, A; Hussain, R; Hwang, BF; Ibitoye, SE; Ikuta, KS; Inbaraj, LR; Iqbal, U; Islam, MS; Islam, SMS; Islam, RM; Ismail, NE; Isola, G; Itumalla, R; Iwagami, M; Iyamu, IO; Jahani, MA; Jakovljevic, M; Jayawardena, R; Jha, RP; John, O; Jonas, JB; Joo, T; Kabir, A; Kalhor, R; Kamath, A; Kanchan, T; Kandel, H; Kapoor, N; Kayode, GA; Kebede, SA; Keshavarz, P; Keykhaei, M; Khader, YS; Khajuria, H; Khan, MAB; Khan, MN; Khan, M; Khater, AM; Khoja, TAM; Khubchandani, J; Kim, MS; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kivimäki, M; Korshunov, VA; Korzh, O; Koyanagi, A; Krishan, K; Defo, BK; Kumar, GA; Kumar, N; Kusuma, D; La Vecchia, C; Lacey, B; Larsson, AO; Lasrado, S; Lee, WC; Lee, CB; Lee, PH; Lee, SWH; Li, MC; Lim, SS; Lim, LL; Lucchetti, G; Majeed, A; Malik, AA; Mansouri, B; Mantovani, LG; Martini, S; Mathur, P; McAlinden, C; Mehedi, N; Mekonnen, T; Menezes, RG; Mersha, AG; Jonasson, JM; Miazgowski, T; Michalek, IM; Mirica, A; Mirrakhimov, EM; Mirza, AZ; Mithra, P; Mohammadian-Hafshejani, A; Mohammadpourhodki, R; Mohammed, A; Mokdad, AH; Molokhia, M; Monasta, L; Moni, MA; Moradpour, F; Moradzadeh, R; Mostafavi, E; Mueller, UO; Murray, CJL; Mustafa, A; Nagel, G; Nangia, V; Naqvi, AA; Nayak, BP; Nazari, J; Ndejjo, R; Negoi, RI; Kandel, N; Nguyen, CT; Nguyen, HLT; Noubiap, JJ; Nowak, C; Oancea, B; Odukoya, OO; Oguntade, AS; Ojo, TT; Olagunju, AT; Onwujekwe, OE; Ortiz, A; Owolabi, MO; Palladino, R; Panda-Jonas, S; Pandi-Perumal, SR; Pardhan, S; Parekh, T; Parvizi, M; Pepito, VCF; Perianayagam, A; Petcu, IR; Pilania, M; Podder, V; Polibin, RV; Postma, MJ; Prashant, A; Rabiee, N; Rabiee, M; Rahimi-Movaghar, V; Rahman, MA; Rahman, MM; Rahman, M; Rahmawaty, S; Rajai, N; Ram, P; Rana, J; Ranabhat, K; Ranasinghe, P; Rao, CR; Rao, S; Rawaf, S; Rawaf, DL; Rawal, L; Renzaho, AMN; Rezaei, N; Rezapour, A; Riahi, SM; Ribeiro, D; Rodriguez, JAB; Roever, L; Rohloff, P; Rwegerera, GM; Ryan, PM; Saber-Ayad, MM; Sabour, S; Saddik, B; Moghaddam, SS; Sahebkar, A; Sahoo, H; Saif-Ur-Rahman, K; Salimzadeh, H; Samaei, M; Sanabria, J; Santric-Milicevic, MM; Sathian, B; Sathish, T; Schlaich, MP; Seidu, AA; Sekerija, M; Kumar, NS; Seylani, A; Shaikh, MA; Shamshad, H; Shawon, MSR; Sheikhbahaei, S; Shetty, JK; Shiri, R; Shivakumar, KM; Shuval, K; Singh, JA; Singh, A; Skryabin, VY; Skryabina, AA; Sofi-Mahmudi, A; Soheili, A; Sun, J; Szerencsés, V; Szócska, M; Tabarés-Seisdedos, R; Tadbiri, H; Tadesse, EG; Tariqujjaman, M; Thankappan, KR; Thapar, R; Thomas, N; Timalsina, B; Tobe-Gai, R; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Car, LT; Tusa, BS; Uddin, R; Upadhyay, E; Tahbaz, SV; Valdez, PR; Vasankari, TJ; Verma, M; Villalobos-Daniel, VE; Vladimirov, SK; Vo, B; Vu, GT; Vukovic, R; Waheed, Y; Wamai, RG; Werdecker, A; Wickramasinghe, ND; Winkler, AS; Wubishet, BL; Xu, XY; Xu, SW; Jabbari, SHY; Yatsuya, H; Yaya, S; Yazie, TSY; Yi, SY; Yonemoto, N; Yunusa, I; Zadey, S; Bin Zaman, S; Zamanian, M; Zamora, N; Zastrozhin, MS; Zastrozhina, A; Zhang, ZJ; Zhong, CW; Zmaili, M; Zumla, A; Naghavi, M; Schmidt, MI

LANCET DIABETES & ENDOCRINOLOGY Vol. 10 ( 3 ) page： 177 - 192 2022.3

Language：English Publisher：The Lancet Diabetes and Endocrinology

Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S2213-8587(21)00349-1

Everyday wishes of older people living with dementia in care planning: a qualitative study Reviewed

Md Razib Mamun, Yoshihisa Hirakawa, KM Saif-Ur-Rahman, Tomoka Sakaguchi, Chifa Chiang, Hiroshi Yatsuya

BMC Health Services Research Vol. 22 ( 1 ) page： 184 2022.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan.

Methods

This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data.

Findings

Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others.

Conclusions

This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

DOI： 10.1186/s12913-022-07606-1

Other Link： https://link.springer.com/article/10.1186/s12913-022-07606-1/fulltext.html

Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh Reviewed

Al-Shoaibi, AAA; Chiang, CF; Khalequzzaman, M; Choudhury, SR; Hirakawa, Y; Islam, SS; Aoyama, A; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 1 ) page： 69 - 79 2022.2

Authorship：Last author Language：English Publisher：Nagoya Journal of Medical Science

This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

DOI： 10.18999/nagjms.84.1.69

Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament Reviewed

Nakashima, H; Imagama, S; Yoshii, T; Egawa, S; Sakai, K; Kusano, K; Nakagawa, Y; Hirai, T; Wada, K; Katsumi, K; Fujii, K; Kimura, A; Furuya, T; Kanchiku, T; Nagamoto, Y; Oshima, Y; Nagoshi, N; Ando, K; Takahata, M; Mori, K; Nakajima, H; Murata, K; Matsunaga, S; Kaito, T; Yamada, K; Kobayashi, S; Kato, S; Ohba, T; Inami, S; Fujibayashi, S; Katoh, H; Kanno, H; Li, YY; Yatsuya, H; Koda, M; Kawaguchi, Y; Takeshita, K; Matsumoto, M; Yamazaki, M; Okawa, A

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 748 2022.1

Language：English Publisher：Scientific Reports

This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

DOI： 10.1038/s41598-021-04727-1

Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study Reviewed International journal

Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

Journal of Atherosclerosis and Thrombosis Vol. 29 ( 10 ) page： 1547 - 1562 2022

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

Aim: We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.Methods: We studied 102,535 participants aged 40–79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (＜18.5, 18.5–20.9, 21.0–22.9 [reference], 23.0–24.9, 25.0–27.4, and ≥ 27.5 kg/m2) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.Results: During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25–27.4 and ≥ 27.5 kg/m2) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m2 for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.Conclusion: A BMI ≥ 25 kg/m2 is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.

DOI： 10.5551/jat.63143

Change in the Number of Patient Safety Reports Through a 16-Year Patient Safety Initiative: A Retrospective Study Focusing on the Incident Severity and Type in a Japanese Hospital. Reviewed International journal

Daisuke Koike, Masahiro Ito, Akihiko Horiguchi, Hiroshi Yatsuya, Atsuhiko Ota

Risk management and healthcare policy Vol. 15 page： 2071 - 2081 2022

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To describe the long-term quantitative change in the number of submissions of patient safety reports after the introduction of a patient safety reporting system, focusing on incident severity and type. PATIENTS AND METHODS: This study was performed at a tertiary care hospital in Japan. Patient safety reports from 2006 to 2020 were retrospectively reviewed. Incident severity was classified from level 0 (near miss) to level 5 (fatality). The incident types included those related to medication, patient care, drains and catheters, procedures and interventions, examinations, medical devices, and blood transfusions. The study period was divided into 1. 2004-2007; 2. 2008-2014; and 3. 2015-2020 based on the implementation of hospital patient safety strategies. The number of reports per hospital worker was compared among the study periods and the incident levels and types. RESULTS: We analyzed 96,332 reports extracted from the patient safety reporting system of the hospital. The total number of reports per hospital worker has increased over time. The numbers of levels 0 and 1 incidents increased throughout the study period. In addition, levels 3a and 3b incidents increased between periods 2 and 3. All incident types, except for procedure and intervention-related incidents, increased between periods 1 and 2 and between periods 1 and 3. The number of procedure and intervention-related incidents increased between periods 2 and 3, although it did not between periods 1 and 2. CONCLUSION: We found increases in the number of patient safety reports according to the incident severity and type. This suggests two contextual changes occurring during the cultural maturity process, which reflected the development of organizational patient safety culture in our institution. The first was the establishment of a reporting attitude in the institution. The second was to overcome barriers to patient safety.

DOI： 10.2147/RMHP.S385453

Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population Reviewed International journal

Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, Hiroshi Yatsuya, Tomonori Okamura

Journal of the American Heart Association Vol. 10 ( 23 ) 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

<sec xml:lang="en">
<title>Background</title>
Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors.

</sec>
<sec xml:lang="en">
<title>Methods and Results</title>
We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol <4.65 mmol/L, systolic blood pressure <120 mm Hg, diastolic blood pressure <80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%–11.9%] versus 19.4% [16.7%–21.4%] for men and 6.9% [1.2%–11.5%] versus 15.4% [12.6%–18.1%] for women).

</sec>
<sec xml:lang="en">
<title>Conclusions</title>
The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.

</sec>

DOI： 10.1161/jaha.121.021753

Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration Reviewed

Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. Reviewed International journal

Atsuhiko Ota, Yuanying Li, Hiroshi Yatsuya, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Yoko Sou, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki Iwasaki, Norie Sawada, Shoichiro Tsugane

Journal of cancer survivorship : research and practice Vol. 15 ( 6 ) page： 912 - 921 2021.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study compared working cancer survivors' self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. METHODS: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. RESULTS: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39-1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16-1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34-2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56-2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01-1.45)) but not in women (76.1% vs. 74.9%). CONCLUSIONS: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. IMPLICATIONS FOR CANCER SURVIVORS: Continuous support to improve cancer survivors' SRHS and physical functional capacity would be necessary even while they are working.

DOI： 10.1007/s11764-020-00984-7

Hiroki Kaneko, Noriko Takashi, Masaaki Matsunaga, Yasuki Ito, Jun Takeuchi, Hiroko Terasaki, Hiroshi Yatsuya, Koji M. Nishiguchi

Graefe's Archive for Clinical and Experimental Ophthalmology Vol. 259 ( 12 ) page： 3589 - 3596 2021.12

Language：English Publishing type：Research paper (scientific journal)

Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

DOI： 10.1007/s00417-021-05280-3

The association of work-related stress according to the demand-control model with aggravation of pre-existing disease during the first state of COVID-19 emergency in Japan. Reviewed

Yupeng He, Hiroshi Yatsuya, Chifa Chiang, Atsuhiko Ota, Ryo Okubo, Tomohiro Ishimaru, Takahiro Tabuchi

Journal of epidemiology Vol. 31 ( 12 ) page： 635 - 640 2021.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: The job environment has changed a lot during the period of coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the association between work-related stress and aggravation of pre-existing disease in workers during the first state of COVID-19 emergency in Japan. METHODS: Data were obtained from a large internet survey conducted between August 25 and September 30, 2020 in Japan. Participants who reported that they had a job as well as current history of disease(s) (i.e., pre-existing conditions) were included (n=3090). Aggravation of pre-existing disease during the state of emergency was self-reported. Work-related stress from April 2020 (since the state of COVID-19 emergency) was assessed according to job demand-control model. Multivariable logistic regression models were used to analyze the association. RESULTS: Aggravation of pre-existing diseases was reported by 334 participants (11%). The numbers of participants with high demand and low control were 112 (18%) and 100 (14%), respectively. Compared to medium demand, high demand was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.77, 95% confidence interval: 1.30-2.42). Low control compared to medium control was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.39, 95% confidence interval: 1.02-1.92). CONCLUSION: Work-related stress during the first state of COVID-19 emergency was associated with aggravation of pre-existing disease during that period.

DOI： 10.2188/jea.JE20210146

Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study. Reviewed International journal

Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

Stroke Vol. 52 ( 11 ) page： 3543 - 3550 2021.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

DOI： 10.1161/STROKEAHA.120.031212

Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study. Reviewed International journal

Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

Atherosclerosis Vol. 335 page： 1 - 7 2021.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIMS: The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort. METHODS: A total of 56,381 adults aged 45-74 years were divided into the non-hobby, having a hobby, and having many hobbies groups. We performed Cox proportional hazard models to estimate the hazard ratio (HRs) for incident CVD, CHD, and stroke after adjusting for potential confounding factors. RESULTS: We identified 3685 incident CVDs (940 CHDs and 2839 strokes) during a median follow-up of 16.3 years. After multivariable adjustment, compared to the non-hobby group, participants having a hobby and many hobbies had a 10% (HR = 0.90 [0.83, 0.97]) and 20% (HR = 0.80 [0.69, 0.93]) lower risk of CVD incidence, respectively. The risk of CHD was lower in those with many hobbies, but the association between having many hobbies and CHD risk was not statistically significant. We also found a similar inverse association for stroke. Compared to the non-hobby group, participants having a hobby and many hobbies had a 13% (HR = 0.87 [0.80, 0.96]) and 20% (HR = 0.80 [0.68, 0.94]) lower risk of stroke. CONCLUSIONS: Having hobbies was associated with a lower risk of CVD. Engagement in hobbies may emerge as an important target for healthy lifestyle promotion for the primary prevention of CVD.

DOI： 10.1016/j.atherosclerosis.2021.09.002

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study

アポリポ蛋白A2のアイソフォームと心筋梗塞発症との関連に関するコホート内症例対照研究多目的コホート(JPHC)研究

木原朋未, 山岸良匡, 本田一文, 池田愛, 八谷寛, 斉藤功, 小久保喜弘, 山地太樹, 島津太一, 澤田典絵, 岩崎基, 磯博康, 津金昌一郎

日本動脈硬化学会総会プログラム・抄録集 Vol. 53回 page： 232 - 232 2021.10

Association of anthropometric indices of obesity with hypertension among public employees in northern Ethiopia: Findings from a cross-sectional survey Reviewed International coauthorship

K. M. Saif-Ur-Rahman, Chifa Chiang, Lemlem Weldegerima Gebremariam, Esayas Haregot Hilawe, Yoshihisa Hirakawa, Atsuko Aoyama, Hiroshi Yatsuya

BMJ Open Vol. 11 ( 9 ) page： e050969 2021.9

Authorship：Corresponding author Language：English Publisher：BMJ Publishing Group

Objectives: The burden of hypertension is increasing in low-income countries, including Ethiopia. Obesity is widely known to be associated with hypertension, but different anthropometric indices of obesity might differ in association with hypertension, which is largely unknown in northern Ethiopia. Design: Data from our previous cross-sectional epidemiological survey were statistically analysed. Setting: Public employees in the regional capital city in northern Ethiopia. Participants: The data of 1380 participants (823 men and 557 non-pregnant women) aged 25 and 64 years were analysed. Outcome measures: The presence of hypertension was the outcome measure and multivariable-adjusted logistic regression analyses were used to investigate the association of body mass index (BMI), waist circumference, and waist-hip ratio in men and women separately. The area under the curve (AUC) for three anthropometric indices for discriminating hypertension was also obtained. Separate analyses were conducted for waist circumference and waist-hip ratio analyses further adjusted for BMI. Results: BMI was linearly associated with hypertension in men (OR for 1 SD increase in BMI 1.45, p=0.001) and women (OR for 1 SD increase in BMI 1.41, p=0.01). The association of waist circumference was independent of BMI both in men (OR for 1 SD increase in waist circumference: 1.74, p=0.002) and women (OR for 1 SD increase in waist circumference: 1.57, p=0.029). The association of waist-hip ratio with hypertension adjusted for BMI was significant in men (OR for 1 SD increase in the waist-hip ratio: 1.46, p&lt
0.001), but was weak and non-significant in women. The AUC for BMI was 0.64 in men and 0.67 in women, while AUC for waist circumference was 0.69 both in men and women. Conclusions: Waist circumference was associated with hypertension independent of BMI among public employees in northern Ethiopia.

DOI： 10.1136/bmjopen-2021-050969

Associations of insomnia with noise annoyance and neighborhood environments: A nationwide cross-sectional study in Japan. Reviewed International journal

Tomoya Hanibuchi, Tomoki Nakaya, Tsuyoshi Kitajima, Hiroshi Yatsuya

Preventive medicine reports Vol. 23 page： 101416 - 101416 2021.9

Language：English Publishing type：Research paper (scientific journal)

Despite the increasing knowledge on the association between neighborhood and health, few studies have investigated sleep disorders in Japan, particularly the impact of neighborhood noise on sleep. Thus, this study aimed to investigate the associations between insomnia symptoms and annoyance because of traffic and neighborhood noise in Japan, which has different neighborhood conditions compared with those of the western societies. Neighborhood built and socioeconomic environments roles were also examined. We used nationwide cross-sectional data collected through a 2015 online survey of Japanese adults aged 20-64 years (n = 4,243). Adjusted prevalence ratios for insomnia according to the exposures were estimated using the multilevel Poisson regression models. The results showed that having insomnia was significantly associated with experiencing neighborhood and traffic-noise annoyance. Neighborhood noise had a stronger and independent association with insomnia. However, the neighborhood environmental variables, including population density, deprivation index, and access to commercial areas, were not associated with insomnia. In conclusion, noise annoyance, particularly that sourced from neighbors, is an important factor in relation to sleep health. Health and urban-planning policymakers should consider neighborhood noise, in addition to traffic noise, as health-related issues in residential neighborhoods.

DOI： 10.1016/j.pmedr.2021.101416

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 2021.9

The association of work-related stress with aggravation of pre-existing disease during COVID-19 emergency in Japan

He, YP; Yatsuya, H; Chiang, C; Ota, A; Okubo, R; Ishimaru, T; Tabuchi, T

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 2021.9

小学2年非肥満児における男女別の推定食塩摂取量、尿中Na/K比と収縮期血圧の関連

金子佳世, 伊藤由起, 加藤沙耶香, 玉田葉月, 松木太郎, 榎原毅, 井上貴子, 杉浦真弓, 齋藤伸治, 八谷寛, 藤田直也, 上島通浩

東海公衆衛生雑誌 Vol. 9 ( 1 ) page： 49 - 49 2021.7

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019 Reviewed International coauthorship International journal

Reitsma, MB; Reitsma, MB; Kendrick, PJ; Ababneh, E; Abbafati, C; Abbasi-Kangevari, M; Abdoli, A; Abedi, A; Abhilash, ES; Abila, DB; Aboyans, V; Abu-Rmeileh, NME; Adebayo, OM; Advani, SM; Aghaali, M; Ahinkorah, BO; Ahmad, S; Ahmadi, K; Ahmed, H; Aji, B; Akunna, CJ; Al-Aly, Z; Alanzi, TM; Alhabib, KF; Ali, L; Alif, SM; Alipour, V; Aljunid, SM; Alla, F; Allebeck, P; Alvis-Guzman, N; Amin, TT; Amini, S; Amu, H; Amul, GGH; Ancuceanu, R; Anderson, JA; Ansari-Moghaddam, A; Antonio, CAT; Antony, B; Anvari, D; Arabloo, J; Arian, ND; Arora, M; Asaad, M; Ausloos, M; Awan, AT; Ayano, G; Aynalem, GL; Azari, S; Darshan, BB; Badiye, AD; Baig, AA; Bakhshaei, MH; Banach, M; Banik, PC; Barker-Collo, SL; Bärnighausen, TW; Barqawi, HJ; Basu, S; Bayati, M; Bazargan-Hejazi, S; Behzadifar, M; Bekuma, TT; Bennett, DA; Bensenor, IM; Berfield, KSS; Bhagavathula, AS; Bhardwaj, N; Bhardwaj, P; Bhattacharyya, K; Bibi, S; Bijani, A; Bintoro, BS; Biondi, A; Birara, S; Braithwaite, D; Brenner, H; Brunoni, AR; Burkart, K; Butt, ZA; dos Santos, FLC; Cámera, LA; Car, J; Cárdenas, R; Carreras, G; Carrero, JJ; Castaldelli-Maia, JM; Cattaruzza, MSS; Chang, JC; Chen, SM; Chu, DT; Chung, SC; Cirillo, M; Costa, VM; Couto, RAS; Dadras, O; Dai, XC; Damasceno, AAM; Damiani, G; Dandona, L; Dandona, R; Daneshpajouhnejad, P; Gela, JD; Davletov, K; Molla, MD; Dessie, GA; Desta, AA; Dharmaratne, SD; Dianatinasab, M; Diaz, D; Do, HT; Douiri, A; Duncan, BB; Duraes, AR; Eagan, AW; Kalan, ME; Edvardsson, K; Elbarazi, I; El Tantawi, M; Esmaeilnejad, S; Fadhil, I; Faraon, EJA; Farinha, CSES; Farwati, M; Farzadfar, F; Fazlzadeh, M; Feigin, VL; Feldman, R; Prendes, CF; Ferrara, P; Filip, I; Filippidis, F; Fischer, F; Flor, LS; Foigt, NA; Folayan, MO; Foroutan, M; Gad, MM; Gaidhane, AM; Gallus, S; Geberemariyam, BS; Ghafourifard, M; Ghajar, A; Ghashghaee, A; Giampaoli, S; Gill, PS; Glozah, FN; Gnedovskaya, EV; Golechha, M; Gopalani, SV; Gorini, G; Goudarzi, H; Goulart, AC; Greaves, F; Guha, A; Guo, YM; Gupta, B; Das Gupta, R; Gupta, R; Gupta, T; Gupta, V; Hafezi-Nejad, N; Haider, MR; Hamadeh, RR; Hankey, GJ; Hargono, A; Hartono, RK; Hassankhani, H; Hay, SI; Heidari, G; Herteliu, C; Hezam, K; Hird, TR; Hole, MK; Holla, R; Hosseinzadeh, M; Hostiuc, S; Househ, M; Hsiao, T; Huang, JJ; Iannucci, VC; Ibitoye, SE; Idrisov, B; Ilesanmi, OS; Ilic, IM; Ilic, MD; Inbaraj, LR; Irvani, SSN; Islam, JY; Islam, RM; Islam, SMS; Islami, F; Iso, H; Itumalla, R; Iwagami, M; Jaafari, J; Jain, V; Jakovljevic, M; Jang, SI; Janjani, H; Jayaram, S; Jeemon, P; Jha, RP; Jonas, JB; Joo, T; Jürisson, M; Kabir, A; Kabir, Z; Kalankesh, LR; Kanchan, T; Kandel, H; Kapoor, N; Karimi, SE; Katikireddi, SV; Kebede, HK; Kelkay, B; Kennedy, RD; Khoja, AT; Khubchandani, J; Kim, GR; Kim, YE; Kimokoti, RW; Kivimäki, M; Kosen, S; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Kugbey, N; Kumar, GA; Kumar, N; Kurmi, OP; Kusuma, D; Lacey, B; Lam, JO; Landires, I; Lasrado, S; Lauriola, P; Lee, DW; Lee, YH; Leung, JN; Li, SS; Lin, HL; Linn, S; Liu, W; Lopez, AD; Lopukhov, PD; Lorkowski, S; Lugo, A; Majeed, A; Maleki, A; Malekzadeh, R; Malta, DC; Mamun, AA; Manjunatha, N; Mansouri, B; Mansournia, MA; Martinez-Raga, J; Martini, S; Mathur, MR; Medina-Solís, CE; Mehata, S; Mendoza, W; Menezes, RG; Meretoja, A; Meretoja, TJ; Miazgowski, B; Michalek, IM; Miller, TR; Mirrakhimov, EM; Mirzaei, H; Mirzaei-Alavijeh, M; Misra, S; Moghadaszadeh, M; Mohammad, Y; Mohammadian-Hafshejani, A; Mohammed, S; Mokdad, AH; Monasta, L; Moni, MA; Moradi, G; Moradi-Lakeh, M; Moradzadeh, R; Morrison, SD; Mossie, TB; Mubarik, S; Mullany, EC; Murray, CJL; Naghavi, M; Naghshtabrizi, B; Nair, S; Nalini, M; Nangia, V; Naqvi, AA; Swamy, SN; Naveed, M; Nayak, S; Nayak, VC; Nazari, J; Nduaguba, SO; Kandel, SN; Nguyen, CT; Nguyen, HLT; Nguyen, SH; Nguyen, TH; Nixon, MR; Nnaji, CA; Norrving, B; Noubiap, JJ; Nowak, C; Ogbo, FA; Oguntade, AS; Oh, IH; Olagunju, AT; Oren, E; Otstavnov, N; Otstavnov, SS; Owolabi, MO; Pakhale, MPAS; Pakshir, K; Palladino, R; Pana, A; Panda-Jonas, S; Pandey, A; Parekh, U; Park, EC; Park, EK; Kan, FP; Patton, GC; Pawar, S; Pestell, RG; Pinheiro, M; Piradov, MA; Pirouzpanah, S; Pokhrel, KN; Polibin, RV; Prashant, A; Pribadi, DRA; Radfar, A; Rahimi-Movaghar, V; Rahman, A; Rahman, MHU; Rahman, MA; Rahmani, AM; Rajai, N; Ram, P; Ranabhat, CL; Rathi, P; Rawal, L; Renzaho, AMN; Reynales-Shigematsu, LM; Rezapour, A; Riahi, SM; Riaz, MA; Roever, L; Ronfani, L; Roshandel, G; Roy, A; Roy, B; Sacco, S; Saddik, B; Sahebkar, A; Salehi, S; Salimzadeh, H; Samaei, M; Samy, AM; Santos, IS; Santric-Milicevic, MM; Sarrafzadegan, N; Sathian, B; Sawhney, M; Saylan, M; Schaub, MP; Schmidt, MI; Schneider, IJC; Schutte, AE; Schwendicke, F; Seidu, AA; Kumar, NS; Sepanlou, SG; Seylani, A; Shafaat, O; Shah, SM; Shaikh, MA; Shalash, AS; Shannawaz, M; Sharafi, K; Sheikh, A; Sheikhbahaei, S; Shigematsu, M; Shiri, R; Shishani, K; Shivakumar, KM; Shivalli, S; Shrestha, R; Siabani, S; Sidemo, NB; Sigfusdottir, ID; Sigurvinsdottir, R; Silva, DAS; Silva, JP; Singh, A; Singh, JA; Singh, V; Sinha, DN; Sitas, F; Skryabin, VY; Skryabina, AA; Soboka, M; Soriano, JB; Soroush, A; Soshnikov, S; Soyiri, IN; Spurlock, EE; Sreeramareddy, CT; Stein, DJ; Steiropoulos, P; Stortecky, S; Straif, K; Abdulkader, RS; Sulo, G; Sundström, J; Tabuchi, T; Tadakamadla, SK; Taddele, BW; Tadesse, EG; Tamiru, AT; Tareke, M; Tareque, MI; Tarigan, IU; Temsah, MH; Thankappan, KR; Thapar, R; Tichopad, A; Tolani, MA; Topouzis, F; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Tsegaye, GW; Tsilimparis, N; Tymeson, HD; Ullah, A; Ullah, S; Unim, B; Updike, RL; Vacante, M; Valdez, PR; Vardavas, C; Pérez, PV; Vasankari, TJ; Venketasubramanian, N; Verma, M; Vetrova, MV; Vo, B; Vu, GT; Waheed, Y; Wang, YZ; Welding, K; Werdecker, A; Whisnant, JL; Wickramasinghe, ND; Yamagishi, K; Yandrapalli, S; Yatsuya, H; Yazdi-Feyzabadi, V; Yeshaw, Y; Yimmer, MZ; Yonemoto, N; Yu, CH; Yunusa, I; Yusefzadeh, H; Moghadam, TZ; Zaman, MS; Zamanian, M; Zandian, H; Zar, HJ; Zastrozhin, MS; Zastrozhina, A; Zavala-Arciniega, L; Zhang, JR; Zhang, ZJ; Zhong, CW; Zuniga, YMH; Gakidou, E

LANCET Vol. 397 ( 10292 ) page： 2337 - 2360 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：The Lancet

Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

DOI： 10.1016/S0140-6736(21)01169-7

Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese Reviewed

What constitutes healthiness of Washoku or Japanese diet? Invited International journal

Hiroshi Yatsuya, Shoichiro Tsugane

European Journal of Clinical Nutrition Vol. 75 ( 6 ) page： 863 - 864 2021.6

Predictive risk factors for pneumothorax after transbronchial biopsy using endobronchial ultrasonography with a guide sheath. Reviewed International journal

Yusuke Gotoh, Teppei Yamaguchi, Hiroshi Yatsuya, Aki Ikeda, Takuya Okamura, Yosuke Sakakibara, Takuma Ina, Yuri Maeda, Mariko Hirochi, Hisashi Kako, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

BMC pulmonary medicine Vol. 21 ( 1 ) page： 181 - 181 2021.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. METHODS: We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary comorbidities); lesion data (location, size, existence of ground-glass opacities [GGOs], pleural involvement, computed tomography [CT] bronchus sign, visibility on fluoroscopy, and EBUS findings); final diagnosis; years of bronchoscopist experience; and guide sheath size. Univariate and multivariate logistic regression analyses were performed. RESULTS: Among the 916 patients, 30 (3.28%) presented with pneumothorax. With a univariate analysis, factors that independently predisposed to pneumothorax included lesions containing GGOs, lesions in sagittal lung segments on fluoroscopy, lesions that were not visible on fluoroscopy, and infectious lesions. A univariate analysis also showed that lesions in the right upper lobe or left upper division, as well as malignant lesions, were less likely to lead to pneumothorax. Age, underlying pulmonary disease, CT bronchus sign, EBUS findings, bronchoscopist experience, and guide sheath size did not influence the incidence of pneumothorax. A multivariate analysis revealed that only lesions containing GGOs (odds ratio [OR] 6.47; 95% confidence interval [CI] 2.13-19.6, P = 0.001) and lesions in lung segments with a sagittal orientation on fluoroscopy (OR 2.47; 95% CI 1.09-5.58, P = 0.029) were significant risk factors for EBUS-GS-TBB-related pneumothorax. CONCLUSIONS: EBUS-GS-TBB of lesions containing GGOs or lesions located in sagittal lung segments on fluoroscopy correlate with a higher pneumothorax risk.

DOI： 10.1186/s12890-021-01551-1

Ito, Y; Ito, M; Iwase, T; Kataoka, K; Yamada, K; Yasuda, S; Ito, H; Takeuchi, J; Nakano, Y; Fujita, A; Horiguchi, E; Taki, Y; Yatsuya, H; Terasaki, H

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 11278 2021.5

Language：English Publisher：Scientific Reports

Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate the prevalence of and risk factors for pachyvessels in the Japanese population. We included 316 participants (aged ≥ 40 years) with normal right eyes. The presence of pachyvessels (vertical diameter > 300 µm, distance to the retinal pigment epithelium < 50 µm) was determined using 6 × 6 mm macular swept-source optical coherence tomography images, and associated risk factors were investigated. Subfoveal choroidal thickness was measured, and its associated risk factors investigated. The overall prevalence of pachychoroids was 9.5%. Regression analysis showed that a younger age, shorter axial length, male sex, and smoking were significantly associated with the presence of pachyvessels (p = 0.047; odds ratio [OR] 0.96 per year, p = 0.021; OR 0.61 per 1 mm, p = 0.012; OR 3.08 vs. female, and p = 0.011; OR 3.15 vs. non-smoker, respectively) and greater choroidal thickness (p < 0.001, p < 0.001, p < 0.003, and p < 0.017, respectively). The results were consistent with other research findings which showed that pachychoroid-related disorders such as central serous chorioretinopathy were associated with younger age, male sex, shorter axial length, and smoking. Smoking may be associated with choroidal circulatory disturbance in the Japanese population.

DOI： 10.1038/s41598-021-90493-z

Inherited chromosomally integrated human herpesvirus 6 is a risk factor for spontaneous abortion. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Tamae Ohye, Fumihiko Hattori, Kei Kozawa, Masaru Ihira, Hiroshi Yatsuya, Haruki Nishizawa, Hiroki Kurahashi, Tetsushi Yoshikawa

The Journal of infectious diseases Vol. 223 ( 10 ) page： 1717 - 1723 2021.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Human herpesvirus 6 (HHV-6) can be genetically transmitted from parent to child as inherited chromosomally integrated HHV-6 (iciHHV-6). HHV-6 reactivation occurs in pregnant women with iciHHV-6. We showed no gender differences in the frequency of index cases with iciHHV-6 but inheritance from the father was more common. We evaluated the association between iciHHV-6 status and spontaneous abortion. METHODS: iciHHV-6 was confirmed by high viral DNA copy numbers in whole blood and somatic cells. The origin of integrated viral genome, paternal or maternal, was examined using the same method. The pregnancy history of 23 mothers in families with iciHHV-6 and 285 mothers in families without iciHHV-6 was abstracted. RESULTS: Of 23 iciHHV-6 index cases, eight mothers and 15 fathers had iciHHV-6. Spontaneous abortion rates in mothers with and mothers without/fathers with iciHHV-6 and mothers in families without iciHHV-6 were 27.6%, 10.3%, and 14.8%, respectively (p = 0.012). Mother with iciHHV-6 (OR 6.41, 95%CI 1.10-37.4) and maternal age at the most recent pregnancy ≥40 years (OR 3.91, 95%CI 1.30-11.8) are associated with two or more spontaneous abortions. CONCLUSION: Mothers with iciHHV-6 is a risk factor for spontaneous abortion.

DOI： 10.1093/infdis/jiaa606

Perceptions and behaviors related to noncommunicable diseases in Palau: a qualitative study Reviewed

Hiroko Shimizu, Yoshihisa Hirakawa, Chifa Chiang, Bernie Ngiralmau, Julita Tellei, Faustina K. Rehuher-Marugg, Takashi Mita, Hiroshi Yatsuya, Atsuko Aoyama

Nagoya Journal of Medical Science Vol. 83 ( 2 ) page： 287 - 298 2021.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Nagoya University

The increasing burden of noncommunicable diseases (NCDs) is a major public health concern in Palau. This study aims to identify social and psychological factors related to NCDs among Palauan people using a qualitative approach. We conducted eight key informant interviews and eight focus group discussions, which were audio-recorded, transcribed and translated into English. Ideas of the respondents were extracted and labeled, and the labels were analyzed using an inductive multistage approach referred to as qualitative content analysis. Three themes emerged: (1) home education, (2) traditional local community, and (3) modernization and westernization of lifestyle. Respondents believed that the influence of the family on lifestyle was significant, but that disciplining children at home had become difficult. They considered that the traditional lifestyle was mostly healthy, and were reluctant to abandon certain unhealthy customs, such as serving abundant food to guests as a sign of fraternity. They also thought that they overate because of their stressful modernized lifestyle. This is the first qualitative study to analyze perception and behavior of the Palauan people in relation to NCDs. We found that the increase in NCDs was related to two concurrent trends: preserving certain traditional customs unfavorable to good health, and abandoning time-consuming healthy traditional lifestyle to adopt a modernized one. We also found that Palauan people were not confident in their ability to prevent NCDs. Therefore, health promotion activities should be designed to empower people to make positive changes.

DOI： 10.18999/nagjms.83.2.287

Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center-based Prospective Study. Reviewed International journal

Koichi Kisanuki, Isao Muraki, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

Atherosclerosis Vol. 322 page： 67 - 73 2021.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIMS: The impact of weight changes in middle age on the incidence of cardiovascular disease has not been well elucidated. We investigated whether a 5-year weight change was associated with risk of stroke and coronary heart disease (CHD) in middle-aged individuals. METHODS: We analyzed data of 74,928 participants aged 40-69 years who provided responses to the baseline and 5-year follow-up questionnaires in the Japan Public Health Center-based Prospective Study. Weight change was calculated by subtracting self-reported weight at baseline from that at 5-year follow-up. Stroke and CHD events were confirmed by reviewing hospital records. RESULTS: During 997,406 person-years of follow-up, we documented 3,975 stroke and 914 CHD events. The multivariable HRs of stroke for losing ≥5 kg compared to stable weight (change ≤2 kg) was 1.17 (95% CI, 1.01-1.37) in men versus 1.33 (1.13-1.57) for losing ≥5 kg and 1.61 (1.36-1.92) for gaining ≥5 kg in women (U-shaped association). These associations did not change after the exclusion of early events. The multivariable HR of CHD for gaining ≥5 kg was 1.22 (0.95-1.58) in men. After exclusion of early events within another 5 years, that positive association became stronger [multivariable HR 1.34 (1.00-1.82)]. CONCLUSIONS: Weight gain during middle age was associated with an increased risk of stroke in women and an increased risk of CHD in men. Weight loss was associated with an increased risk of stroke in both men and women.

DOI： 10.1016/j.atherosclerosis.2021.02.017

Avoid clinical inertia: importance of asking and advising patients with diabetes who smoke about quitting. Reviewed

Hiroshi Yatsuya

Journal of diabetes investigation Vol. 12 ( 3 ) page： 317 - 319 2021.3

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The goal of diabetes care is to prevent complications and maximize quality of life of the patients. Evidence-based glycemic control is the centerpiece for achieving that goal. At the same time, more emphasis should also be put on managing other risk factors. A recent study published in Lancet Diabetes and Endocrinology confirmed that we should ask all the patients with diabetes whether they smoke, and if so, we should advise them to stop smoking immediately1 .

DOI： 10.1111/jdi.13421

Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia. Reviewed International coauthorship International journal

Yupeng He, Chifa Chiang, Lemlem Weldegerima Gebremariam, Yoshihisa Hirakawa, Hiroshi Yatsuya, Atsuko Aoyama

Asia-Pacific journal of public health Vol. 33 ( 2-3 ) page： 242 - 250 2021.3

Language：English Publishing type：Research paper (scientific journal)

The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non-high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

DOI： 10.1177/1010539520974848

Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau Reviewed International coauthorship

Mizuki Sata, Renzhe Cui, Chifa Chiang, Singeru Travis Singeo, Berry Moon Watson, Hiroshi Yatsuya, Kaori Honjo, Takashi Mita, Everlynn Joy Temengil, Sherilynn Madraisau, Kazumasa Yamagishi, Atsuko Aoyama, Hiroyasu Iso

Environmental Health and Preventive Medicine Vol. 26 ( 1 ) page： 12 2021.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

<title>Abstract</title><sec>
<title>Background</title>
This study aimed to describe the status of alcohol consumption and drug use among young adults as well as their determinants.

</sec><sec>
<title>Methods</title>
We conducted a cross-sectional study of 356 young adults (aged 18 to 24 years) living in Palau in 2013. The prevalence of self-reported alcohol and marijuana usage were compared within and between sexes, age groups, ethnicities, and education levels.

</sec><sec>
<title>Results</title>
The proportion of current drinking was higher in people aged 21–24 than in those aged 18–20 (73.2% vs. 60.9%, <italic>p</italic> = 0.09 in men and 48.3% vs. 30.0%, <italic>p</italic> = 0.02 in women), while that of marijuana use did not differ between the age groups. The proportions of current drinking and marijuana use were higher in Palauan than in other ethnicities (current drinking: 70.6% vs. 40.6%, <italic>p</italic> = 0.005 in men and 38.8% vs. 16.6%, <italic>p</italic> = 0.04 in women; lifetime marijuana use: 80.0% vs. 52.9%, <italic>p</italic> = 0.02 in men and 56.1% vs. 30.6%, <italic>p</italic> = 0.09 in women). The proportion of frequent (3 times or more) marijuana users was higher for the lower educated than for the higher educated (62.5% vs. 32.1%, <italic>p</italic> < 0.001 in men and 33.9% vs. 24.4%, <italic>p</italic> = 0.12 in women).

</sec><sec>
<title>Conclusions</title>
Sex, age, ethnicity, and education were significant determinants of alcohol and marijuana use.

</sec>

DOI： 10.1186/s12199-020-00928-8

Other Link： http://link.springer.com/article/10.1186/s12199-020-00928-8/fulltext.html

Health of university students under job and financial insecurity during COVID-19 pandemic Invited

Hiroshi Yatsuya, Tatsuya Ishitake

Journal of occupational health Vol. 63 ( 1 ) page： e12223 2021.1

KM Saif‐Ur‐Rahman, Razib Mamun, Yuanying Li, Masaaki Matsunaga, Atsuhiko Ota, Hiroshi Yatsuya

Journal of Occupational Health Vol. 63 ( 1 ) page： e12278 2021.1

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Background: Diabetes is a major risk factor for cardiovascular diseases (CVD). This systematic review aims to explore the work-related factors among people with diabetes in developing CVD.Methods: Four electronic databases were searched on 1 February 2021 using a comprehensive search strategy without any time restriction. Two independent researchers screened the articles and extracted data. The risk of bias was assessed independently using the risk of bias assessment tool for non-randomized studies (RoBANS). A narrative synthesis was conducted considering the heterogeneity of the included articles.Results: A total of five articles incorporating 4 409 810 participants from three geographic regions were included that highlights the research gap. As per the included studies, Occupational drivers with diabetes were at a higher risk of CVD in comparison to the nondrivers, workers with diabetes having a long working hour were at a higher risk of CVD mortality, workers with a lower occupational status were at a higher risk of 10-years stroke risk, and occupational physical activity and occupational commuting lowered the risk of CVD deaths.Conclusions: This systematic review summarized the available evidence on work-related factors influencing the risk of CVD in people with diabetes. The findings should be interpreted cautiously pondering the limited evidence and imprecision. We identified only five articles related to the topic, and there were no studies from Japan. The scarcity of studies on work-related factors on the prognosis of diabetic patients implies the need for more research in this field. We recommend further exploration of the topic designing primary studies.

DOI： 10.1002/1348-9585.12278

Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/1348-9585.12278

一般的な代謝結果を予測するための人工ニューラルネットワークおよびロジスティック回帰の比較(Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes)

He Yupeng, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi

Journal of Epidemiology Vol. 31 ( Suppl.1 ) page： 138 - 138 2021.1

Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study. Reviewed

Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

Journal of atherosclerosis and thrombosis Vol. 28 ( 5 ) page： 483 - 490 2021

Language：English Publishing type：Research paper (scientific journal)

AIM: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. METHODS: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. RESULTS: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91-4.97) or drinking only (OR=2.07; 0.91-4.74), and the multivariable OR was 1.20 (95% CI, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction. CONCLUSIONS: Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

DOI： 10.5551/jat.56218

Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN. Reviewed

Yuanying Li, Hiroshi Yatsuya, Sachiko Tanaka, Hiroyasu Iso, Akira Okayama, Ichiro Tsuji, Kiyomi Sakata, Yoshihiro Miyamoto, Hirotsugu Ueshima, Katsuyuki Miura, Yoshitaka Murakami, Tomonori Okamura

Journal of atherosclerosis and thrombosis Vol. 28 ( 8 ) page： 816 - 825 2021

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

AIMS: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). METHODS: We evaluated a total of 44,869 individuals aged 40-79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect meta-analyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. RESULTS: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. CONCLUSIONS: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.

DOI： 10.5551/jat.58958

Pelvic exenteration associated with future renal dysfunction. Reviewed

Masanori Sando, Kay Uehara, Yuanying Li, Toshisada Aiba, Atsushi Ogura, Tomoki Ebata, Yasuhiro Kodera, Hiroshi Yatsuya, Masato Nagino

Surgery today Vol. 50 ( 12 ) page： 1601 - 1609 2020.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study aimed to clarify the long-term change in the renal function after pelvic exenteration (PE) and to evaluate the risk factors for any future dysfunction. METHODS: This study comprised 40 patients. A greater than 25% decline in the estimated glomerular filtration rate (eGFR) at 3 years was defined as early renal function disorder (ERFD), possibly predicting future chronic kidney disease (CKD). RESULTS: In the entire cohort, the median eGFR decreased by 23% at 3 years, and CKD developed in 50%. The patients were divided into the ERFD (n = 16) and non-ERFD (n = 24) groups. In the ERFD group, the eGFR significantly decreased by 28% during the first 1.5 years and continued to decline after that, resulting in 81.3% of patients reaching CKD, whereas it was 4% and 37.5%, respectively, in the non-ERFD group. In a growth model analysis, late urinary tract complications (UTC) and small bowel obstruction were shown to be risk factors for ERFD. CONCLUSION: Although PE was associated with a high incidence of future CKD, ERFD could predict it. Close observation of the eGFR decline over 1.5 years might be beneficial to identify ERFD patients. High-risk patients with late UTC and small bowel obstruction should, therefore, be observed carefully.

DOI： 10.1007/s00595-020-02036-0

Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele. Reviewed International coauthorship International journal

Hailan Wang, Tamie Nakajima, Yuki Ito, Hisao Naito, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hongyung Qu, Hiroshi Yatsuya, Michihiro Kamijima

Environmental research Vol. 191 page： 109972 - 109972 2020.12

Language：English Publishing type：Research paper (scientific journal)

Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to ≤50 mg/L and of >50 mg/L were 21.9 [95% confidence interval (CI) 4.2-114.1] and 27.6 (6.1-125.8), respectively, when the group with urinary TCA ≤15 mg/L was used as a reference. The frequency of HLA-B*13:01, the most common allele in the patients, was 62.2% (23/37), which was significantly higher than 17.5% (17/97) in the TCE-tolerant controls, with a crude OR of 8.4 (3.1-22.6). The mutually-adjusted ORs for urinary TCA >15 to ≤50 mg/L, >50 mg/L, and for HLA-B*13:01 were 33.4 (4.1-270.8), 34.0 (5.3-217.1), and 11.0 (2.4-50.7), respectively. In conclusion, reduction of TCE exposure to ≤15 mg/L is required for TCE-HS prevention because urinary TCA concentration >15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele.

DOI： 10.1016/j.envres.2020.109972

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 Reviewed International coauthorship

Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noël C. Barengo, Andrea Z. Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aimé Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan Carapetis, Alberico L. Catapano, Sumeet S. Chugh, Leslie T. Cooper, Josef Coresh, Michael Criqui, Nicole DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Solà, Gerry Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas Kassebaum, Walter Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke Misganaw Temesgen, Ali Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Glaucia Moraes de Oliveira, Catherine Otto, Mayowa Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa Reitsma, Antonio Luiz P. Ribeiro, Nancy Rigotti, Anthony Rodgers, Craig Sable, Saate Shakil, Karen Sliwa-Hahnle, Benjamin Stark, Johan Sundström, Patrick Timpel, Imad M. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl Zuhlke, Christopher Murray, Valentin Fuster, Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noel C. Barengo, Andrea Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aime Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan R. Carapetis, Alberico L. Catapano, Sumeet Chugh, Leslie T. Cooper, Josef Coresh, Michael H. Criqui, Nicole K. DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Sola, F. Gerry R. Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas J. Kassebaum, Walter J. Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke T. Misganaw, Ali H. Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Gláucia M.M. Oliveira, Catherine M. Otto, Mayowa O. Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa B. Reitsma, Antonio Luiz P. Ribeiro, Nancy A. Rigotti, Anthony Rodgers, Craig A. Sable, Saate S. Shakil, Karen Sliwa, Benjamin A. Stark, Johan Sundström, Patrick Timpel, Imad I. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl J. Zuhlke, Mohsen Abbasi-Kangevari, Alireza Abdi, Aidin Abedi, Victor Aboyans, Woldu A. Abrha, Eman Abu-Gharbieh, Abdelrahman I. Abushouk, Dilaram Acharya, Tim Adair, Oladimeji M. Adebayo, Zanfina Ademi, Shailesh M. Advani, Khashayar Afshari, Ashkan Afshin, Gina Agarwal, Pradyumna Agasthi, Sohail Ahmad, Sepideh Ahmadi, Muktar B. Ahmed, Budi Aji, Yonas Akalu, Wuraola Akande-Sholabi, Addis Aklilu, Chisom J. Akunna, Fares Alahdab, Ayman Al-Eyadhy, Khalid F. Alhabib, Sheikh M. Alif, Vahid Alipour, Syed M. Aljunid, François Alla, Amir Almasi-Hashiani, Sami Almustanyir, Rajaa M. Al-Raddadi, Adeladza K. Amegah, Saeed Amini, Arya Aminorroaya, Hubert Amu, Dickson A. Amugsi, Robert Ancuceanu, Deanna Anderlini, Tudorel Andrei, Catalina Liliana Andrei, Alireza Ansari-Moghaddam, Zelalem A. Anteneh, Ippazio Cosimo Antonazzo, Benny Antony, Razique Anwer, Lambert T. Appiah, Jalal Arabloo, Johan Ärnlöv, Kurnia D. Artanti, Zerihun Ataro, Marcel Ausloos, Leticia Avila-Burgos, Asma T. Awan, Mamaru A. Awoke, Henok T. Ayele, Muluken A. Ayza, Samad Azari, Darshan B. B, Nafiseh Baheiraei, Atif A. Baig, Ahad Bakhtiari, Maciej Banach, Palash C. Banik, Emerson A. Baptista, Miguel A. Barboza, Lingkan Barua, Sanjay Basu, Neeraj Bedi, Yannick Béjot, Derrick A. Bennett, Isabela M. Bensenor, Adam E. Berman, Yihienew M. Bezabih, Akshaya S. Bhagavathula, Sonu Bhaskar, Krittika Bhattacharyya, Ali Bijani, Boris Bikbov, Mulugeta M. Birhanu, Archith Boloor, Luisa C. Brant, Hermann Brenner, Nikolay I. Briko, Zahid A. Butt, Florentino Luciano Caetano dos Santos, Leah E. Cahill, Lucero Cahuana-Hurtado, Luis A. Cámera, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Josip Car, Juan J. Carrero, Felix Carvalho, Carlos A. Castañeda-Orjuela, Ferrán Catalá-López, Ester Cerin, Jaykaran Charan, Vijay Kumar Chattu, Simiao Chen, Ken L. Chin, Jee-Young J. Choi, Dinh-Toi Chu, Sheng-Chia Chung, Massimo Cirillo, Sean Coffey, Sara Conti, Vera M. Costa, David K. Cundiff, Omid Dadras, Baye Dagnew, Xiaochen Dai, Albertino A.M. Damasceno, Lalit Dandona, Rakhi Dandona, Kairat Davletov, Vanessa De la Cruz-Góngora, Fernando P. De la Hoz, Jan-Walter De Neve, Edgar Denova-Gutiérrez, Meseret Derbew Molla, Behailu T. Derseh, Rupak Desai, Günther Deuschl, Samath D. Dharmaratne, Meghnath Dhimal, Raja Ram Dhungana, Mostafa Dianatinasab, Daniel Diaz, Shirin Djalalinia, Klara Dokova, Abdel Douiri, Bruce B. Duncan, Andre R. Duraes, Arielle W. Eagan, Sanam Ebtehaj, Aziz Eftekhari, Sahar Eftekharzadeh, Michael Ekholuenetale, Nevine El Nahas, Islam Y. Elgendy, Muhammed Elhadi, Shaimaa I. El-Jaafary, Sadaf Esteghamati, Atkilt E. Etisso, Oghenowede Eyawo, Ibtihal Fadhil, Emerito Jose A. Faraon, Pawan S. Faris, Medhat Farwati, Farshad Farzadfar, Eduarda Fernandes, Carlota Fernandez Prendes, Pietro Ferrara, Irina Filip, Florian Fischer, David Flood, Takeshi Fukumoto, Mohamed M. Gad, Shilpa Gaidhane, Morsaleh Ganji, Jalaj Garg, Abadi K. Gebre, Birhan G. Gebregiorgis, Kidane Z. Gebregzabiher, Gebreamlak G. Gebremeskel, Lemma Getacher, Abera Getachew Obsa, Alireza Ghajar, Ahmad Ghashghaee, Nermin Ghith, Simona Giampaoli, Syed Amir Gilani, Paramjit S. Gill, Richard F. Gillum, Ekaterina V. Glushkova, Elena V. Gnedovskaya, Mahaveer Golechha, Kebebe B. Gonfa, Amir Hossein Goudarzian, Alessandra C. Goulart, Jenny S. Guadamuz, Avirup Guha, Yuming Guo, Rajeev Gupta, Vladimir Hachinski, Nima Hafezi-Nejad, Teklehaimanot G. Haile, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Arief Hargono, Risky K. Hartono, Maryam Hashemian, Abdiwahab Hashi, Shoaib Hassan, Hamid Y. Hassen, Rasmus J. Havmoeller, Simon I. Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Ramesh Holla, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Junjie Huang, Ayesha Humayun, Ivo Iavicoli, Charles U. Ibeneme, Segun E. Ibitoye, Olayinka S. Ilesanmi, Irena M. Ilic, Milena D. Ilic, Usman Iqbal, Seyed Sina N. Irvani, Sheikh Mohammed Shariful Islam, Rakibul M. Islam, Hiroyasu Iso, Masao Iwagami, Vardhmaan Jain, Tahereh Javaheri, Sathish Kumar Jayapal, Shubha Jayaram, Ranil Jayawardena, Panniyammakal Jeemon, Ravi P. Jha, Jost B. Jonas, Jitendra Jonnagaddala, Farahnaz Joukar, Jacek J. Jozwiak, Mikk Jürisson, Ali Kabir, Tanvir Kahlon, Rizwan Kalani, Rohollah Kalhor, Ashwin Kamath, Ibrahim Kamel, Himal Kandel, Amit Kandel, André Karch, Ayele Semachew Kasa, Patrick D.M.C. Katoto, Gbenga A. Kayode, Yousef S. Khader, Mohammad Khammarnia, Muhammad S. Khan, Md Nuruzzaman Khan, Maseer Khan, Ejaz A. Khan, Khaled Khatab, Gulam M.A. Kibria, Yun Jin Kim, Gyu Ri Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Dhaval Kolte, Ali Koolivand, Vladimir A. Korshunov, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Vijay Krishnamoorthy, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Vaman Kulkarni, G. Anil Kumar, Nithin Kumar, Om P. Kurmi, Dian Kusuma, Gene F. Kwan, Carlo La Vecchia, Ben Lacey, Tea Lallukka, Qing Lan, Savita Lasrado, Zohra S. Lassi, Paolo Lauriola, Wayne R. Lawrence, Avula Laxmaiah, Kate E. LeGrand, Ming-Chieh Li, Bingyu Li, Shanshan Li, Stephen S. Lim, Lee-Ling Lim, Hualiang Lin, Ziqiang Lin, Ro-Ting Lin, Xuefeng Liu, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Alessandra Lugo, Nirmal K. M, Fabiana Madotto, Morteza Mahmoudi, Azeem Majeed, Reza Malekzadeh, Ahmad A. Malik, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Lorenzo G. Mantovani, Santi Martini, Manu R. Mathur, Giampiero Mazzaglia, Suresh Mehata, Man Mohan Mehndiratta, Toni Meier, Ritesh G. Menezes, Atte Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Irmina Maria Michalek, Ted R. Miller, Erkin M. Mirrakhimov, Hamed Mirzaei, Babak Moazen, Masoud Moghadaszadeh, Yousef Mohammad, Dara K. Mohammad, Shafiu Mohammed, Mohammed A. Mohammed, Yaser Mokhayeri, Mariam Molokhia, Ahmed A. Montasir, Ghobad Moradi, Rahmatollah Moradzadeh, Paula Moraga, Lidia Morawska, Ilais Moreno Velásquez, Jakub Morze, Sumaira Mubarik, Walter Muruet, Kamarul Imran Musa, Ahamarshan J. Nagarajan, Mahdi Nalini, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Bruno R. Nascimento, Vinod C. Nayak, Javad Nazari, Milad Nazarzadeh, Ruxandra I. Negoi, Sandhya Neupane Kandel, Huong L.T. Nguyen, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Brice E. Nouthe, Christoph Nowak, Oluwakemi O. Odukoya, Felix A. Ogbo, Andrew T. Olagunju, Hans Orru, Alberto Ortiz, Samuel M. Ostroff, Jagadish Rao Padubidri, Raffaele Palladino, Adrian Pana, Songhomitra Panda-Jonas, Utsav Parekh, Eun-Cheol Park, Mojtaba Parvizi, Fatemeh Pashazadeh Kan, Urvish K. Patel, Mona Pathak, Rajan Paudel, Veincent Christian F. Pepito, Arokiasamy Perianayagam, Norberto Perico, Hai Q. Pham, Thomas Pilgrim, Michael A. Piradov, Farhad Pishgar, Vivek Podder, Roman V. Polibin, Akram Pourshams, Dimas R.A. Pribadi, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Ivo Rakovac, Pradhum Ram, Sudha Ramalingam, Juwel Rana, Priyanga Ranasinghe, Sowmya J. Rao, Priya Rathi, Lal Rawal, Wasiq F. Rawasia, Reza Rawassizadeh, Giuseppe Remuzzi, Andre M.N. Renzaho, Aziz Rezapour, Seyed Mohammad Riahi, Ross L. Roberts-Thomson, Leonardo Roever, Peter Rohloff, Michele Romoli, Gholamreza Roshandel, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Maha M. Saber-Ayad, Siamak Sabour, Simona Sacco, Masoumeh Sadeghi, Sahar Saeedi Moghaddam, Saeed Safari, Amirhossein Sahebkar, Sana Salehi, Hamideh Salimzadeh, Mehrnoosh Samaei, Abdallah M. Samy, Itamar S. Santos, Milena M. Santric-Milicevic, Nizal Sarrafzadegan, Arash Sarveazad, Thirunavukkarasu Sathish, Monika Sawhney, Mete Saylan, Maria I. Schmidt, Aletta E. Schutte, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Feng Sha, Saeed Shahabi, Izza Shahid, Masood A. Shaikh, Mahdi Shamali, Morteza Shamsizadeh, Md Shajedur Rahman Shawon, Aziz Sheikh, Mika Shigematsu, Min-Jeong Shin, Jae Il Shin, Rahman Shiri, Ivy Shiue, Kerem Shuval, Soraya Siabani, Tariq J. Siddiqi, Diego A.S. Silva, Jasvinder A. Singh, Ambrish Singh Mtech, Valentin Y. Skryabin, Anna A. Skryabina, Amin Soheili, Emma E. Spurlock, Leo Stockfelt, Stefan Stortecky, Saverio Stranges, Rizwan Suliankatchi Abdulkader, Hooman Tadbiri, Eyayou G. Tadesse, Degena B. Tadesse, Masih Tajdini, Md Tariqujjaman, Berhane F. Teklehaimanot, Mohamad-Hani Temsah, Ayenew K. Tesema, Bhaskar Thakur, Kavumpurathu R. Thankappan, Rekha Thapar, Amanda G. Thrift, Binod Timalsina, Marcello Tonelli, Mathilde Touvier, Marcos R. Tovani-Palone, Avnish Tripathi, Jaya P. Tripathy, Thomas C. Truelsen, Guesh M. Tsegay, Gebiyaw W. Tsegaye, Nikolaos Tsilimparis, Biruk S. Tusa, Stefanos Tyrovolas, Krishna Kishore Umapathi, Brigid Unim, Bhaskaran Unnikrishnan, Muhammad S. Usman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi J. Vasankari, Diana Z. Velazquez, Narayanaswamy Venketasubramanian, Giang T. Vu, Isidora S. Vujcic, Yasir Waheed, Yanzhong Wang, Fang Wang, Jingkai Wei, Robert G. Weintraub, Abrha H. Weldemariam, Ronny Westerman, Andrea S. Winkler, Charles S. Wiysonge, Charles D.A. Wolfe, Befikadu Legesse Wubishet, Gelin Xu, Ali Yadollahpour, Kazumasa Yamagishi, Lijing L. Yan, Srikanth Yandrapalli, Yuichiro Yano, Hiroshi Yatsuya, Tomas Y. Yeheyis, Yigizie Yeshaw, Christopher S. Yilgwan, Naohiro Yonemoto, Chuanhua Yu, Hasan Yusefzadeh, Geevar Zachariah, Sojib Bin Zaman, Muhammed S. Zaman, Maryam Zamanian, Ramin Zand, Alireza Zandifar, Afshin Zarghi, Mikhail S. Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Yunquan Zhang, Wangjian Zhang, Chenwen Zhong, Zhiyong Zou, Yves Miel H. Zuniga, Christopher J.L. Murray, Valentin Fuster

Journal of the American College of Cardiology Vol. 76 ( 25 ) page： 2982 - 3021 2020.12

Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. Reviewed International journal

Yoshiki Kawamura, Takako Hashimoto, Hiroki Miura, Kei Kozawa, Akiko Yoshikawa, Naomi Ikeda, Hiroshi Yatsuya, Hidekata Yasuoka, Tetsushi Yoshikawa

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Vol. 132 page： 104656 - 104656 2020.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Entire genome of human herpesvirus 6 (HHV-6) that integrates into human chromosomes is called chromosomally integrated HHV-6 (ciHHV-6). Several viral infections have been suggested to be involved in autoimmune connective tissue diseases (CTDs). Reactivated HHV-6 from the integrated viral genome can induce immune responses against the virus. Thus, it is plausible that ciHHV-6 is associated with autoimmune CTDs. OBJECTIVES: We sought to determine whether the prevalence of ciHHV-6 was significantly higher in patients with autoimmune CTDs than in a healthy population. STUDY DESIGN: A total of 846 peripheral blood samples collected from autoimmune CTD patients were analyzed. Since there was a large number of samples, they were pooled into 24 samples per group. Copy numbers of HHV-6 DNA were measured by real-time PCR. The threshold level for distinguishing between ciHHV-6 and active viral infection and the reliability of pooled DNA analysis were examined as initial validation experiments. RESULTS: The threshold level was 1.6 × 10^6 copy/mL in whole blood. The reliability of pooled DNA analysis to identify one ciHHV-6 sample among 23 HHV-6 DNA-negative samples was high. No HHV-6 DNA was detected in any of the pooled DNA samples collected from the patients. The probability of the present study including the 846 autoimmune CTD patient's samples was statistically not different with a healthy Japanese population which was 0.2 % or 0.6 %. CONCLUSIONS: There was no significant difference in the prevalence of ciHHV-6 between a healthy population and patients with autoimmune CTDs.

DOI： 10.1016/j.jcv.2020.104656

Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study. Reviewed

Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study. Reviewed International journal

Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Atsuhiko Ota, Hisao Naito, Rei Otsuka, Chiyoe Murata, Yoshihisa Hirakawa, Chifa Chiang, Mayu Uemura, Koji Tamakoshi, Atsuko Aoyama

International journal of environmental research and public health Vol. 17 ( 21 ) page： 1 - 14 2020.11

Language：English Publishing type：Research paper (scientific journal)

We examined the association between objective and perceived neighborhood characteristics and self-reported leisure-time physical activity (PA) in older Japanese residents living in areas ranging from metropolitan to rural in 2016. Objective measures used were walkability and the numbers of parks/green spaces and sports facilities within 500 or 1000 m of subjects' homes, calculated using geographic information systems. Subjective measures were the subjects' perceptions of their neighborhoods, assessed using a structured questionnaire. All variables were divided into three groups, and the lowest tertile was used as the reference. We assessed the location and frequency of strolling or brisk walking, moderate-intensity PA, and vigorous-intensity PA (sports) using a self-reported questionnaire and defined as performing a certain type of PA 3-4 times/week as a habit. Living in a neighborhood in the highest tertile for walkability and number of parks/green spaces as well as perception of having good access to recreational facilities, observing others exercising and the presence of walkable sidewalks was associated with walking and sports habits (multivariable odds ratios (ORs): 1.33-2.46, all p < 0.05). Interestingly, objective measures of PA-friendly environmental features were inversely associated with moderate-intensity PA habits, potentially because moderate-intensity PA consisted predominantly of gardening. In conclusion, living in an environment supportive of PA, whether objectively or subjectively measured, is related to leisure-time PA habits among older Japanese adults.

DOI： 10.3390/ijerph17217971

Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets. Reviewed International coauthorship International journal

Kunihiro Matsushita, Simerjot K Jassal, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Johan Arnlov, Nisha Bansal, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai-Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih-Jen Hwang, Tazeen H Jafar, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, David Mj Naimark, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Charumathi Sabanayagam, Toshimi Sairenchi, Markus P Schneider, Varda Shalev, Michael Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee-Moon Wang, Chi-Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Elke Schaeffner, Josef Coresh

EClinicalMedicine Vol. 27 page： 100552 - 100552 2020.10

Language：English Publishing type：Research paper (scientific journal)

Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. "CKD Patch" is a validated method to calibrate and improve the predicted risk from established equations according to CKD measures. Methods: Utilizing data from 4,143,535 adults from 35 datasets, we developed several "CKD Patches" incorporating eGFR and albuminuria, to enhance prediction of risk of atherosclerotic CVD (ASCVD) by the Pooled Cohort Equation (PCE) and CVD mortality by Systematic COronary Risk Evaluation (SCORE). The risk enhancement by CKD Patch was determined by the deviation between individual CKD measures and the values expected from their traditional CVD risk factors and the hazard ratios for eGFR and albuminuria. We then validated this approach among 4,932,824 adults from 37 independent datasets, comparing the original PCE and SCORE equations (recalibrated in each dataset) to those with addition of CKD Patch. Findings: We confirmed the prediction improvement with the CKD Patch for CVD mortality beyond SCORE and ASCVD beyond PCE in validation datasets (Δc-statistic 0.027 [95% CI 0.018-0.036] and 0.010 [0.007-0.013] and categorical net reclassification improvement 0.080 [0.032-0.127] and 0.056 [0.044-0.067], respectively). The median (IQI) of the ratio of predicted risk for CVD mortality with CKD Patch vs. the original prediction with SCORE was 2.64 (1.89-3.40) in very high-risk CKD (e.g., eGFR 30-44 ml/min/1.73m2 with albuminuria ≥30 mg/g), 1.86 (1.48-2.44) in high-risk CKD (e.g., eGFR 45-59 ml/min/1.73m2 with albuminuria 30-299 mg/g), and 1.37 (1.14-1.69) in moderate risk CKD (e.g., eGFR 60-89 ml/min/1.73m2 with albuminuria 30-299 mg/g), indicating considerable risk underestimation in CKD with SCORE. The corresponding estimates for ASCVD with PCE were 1.55 (1.37-1.81), 1.24 (1.10-1.54), and 1.21 (0.98-1.46). Interpretation: The "CKD Patch" can be used to quantitatively enhance ASCVD and CVD mortality risk prediction equations recommended in major US and European guidelines according to CKD measures, when available. Funding: US National Kidney Foundation and the NIDDK.

DOI： 10.1016/j.eclinm.2020.100552

Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes. Reviewed International journal

Madoka Matsushita, Akiko Muramoto, Eri Nomura, Yukari Eguchi, Ayako Kato, Yoshiko Sano, Mai Kabayama, Masashi Arakawa, Yuko Oguma, Daisuke Yabe, Masaaki Matsunaga, Hiroshi Yatsuya, Hiroshi Arima, Kazuyo Tsushita

Nutrition & diabetes Vol. 10 ( 1 ) page： 34 - 34 2020.9

Language：English Publishing type：Research paper (scientific journal)

Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.

DOI： 10.1038/s41387-020-00137-w

Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

Journal of diabetes investigation Vol. 11 ( 5 ) page： 1163 - 1169 2020.9

Language：English Publishing type：Research paper (scientific journal)

AIMS/INTRODUCTION: The Japanese government started a nationwide screening program for metabolic syndrome (MetS) to prevent cardiovascular diseases and diabetes in 2008. Although impaired fasting glucose (IFG) is a strong predictor for type 2 diabetes mellitus, the program does not follow up IFG in non-MetS individuals. This study aimed to examine the risk and the population attributable fraction (PAF) of MetS and IFG for incidence of type 2 diabetes mellitus. MATERIALS AND METHODS: Japanese workers (3,417 men and 714 women) aged 40-64 years without a history of diabetes were prospectively followed. MetS was defined as either abdominal obesity plus two or more metabolic risk factors, or being overweight in the case of normal waist circumference plus three or more metabolic risk factors. IFG was defined as fasting blood glucose 100-125 mg/dL. RESULTS: During a mean 6.3 years, 240 type 2 diabetes mellitus cases were identified. Compared with those without MetS and IFG, the multivariable-adjusted hazard ratios (95% confidence interval) of non-MetS individuals with IFG, MetS individuals without IFG and MetS individuals with IFG for type 2 diabetes mellitus were 4.9 (3.4-7.1), 2.4 (1.6-3.5) and 8.3 (5.9-11.5), respectively. The corresponding PAFs for type 2 diabetes mellitus incidence were 15.6, 9.1 and 29.7%, respectively. CONCLUSIONS: IFG represented a higher risk and PAF than MetS for type 2 diabetes mellitus incidence in middle-aged Japanese individuals. The coexistence of MetS and IFG showed the highest risk and PAF for type 2 diabetes mellitus incidence. The current Japanese MetS screening program should be reconsidered to follow up non-MetS individuals with IFG.

DOI： 10.1111/jdi.13230

Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis. Reviewed International coauthorship International journal

Chaochen Wang, Hiroshi Yatsuya, Yingsong Lin, Tae Sasakabe, Sayo Kawai, Shogo Kikuchi, Hiroyasu Iso, Akiko Tamakoshi

Nutrients Vol. 12 ( 9 ) 2020.9

Language：English Publishing type：Research paper (scientific journal)

The aim of this study was to further examine the relationship between milk intake and stroke mortality among the Japanese population. We used data from the Japan Collaborative Cohort (JACC) Study (total number of participants = 110,585, age range: 40-79) to estimate the posterior acceleration factors (AF) as well as the hazard ratios (HR) comparing individuals with different milk intake frequencies against those who never consumed milk at the study baseline. These estimations were computed through a series of Bayesian survival models that employed a Markov Chain Monte Carlo simulation process. In total, 100,000 posterior samples were generated separately through four independent chains after model convergency was confirmed. Posterior probabilites that daily milk consumers had lower hazard or delayed mortality from strokes compared to non-consumers was 99.0% and 78.0% for men and women, respectively. Accordingly, the estimated posterior means of AF and HR for daily milk consumers were 0.88 (95% Credible Interval, CrI: 0.81, 0.96) and 0.80 (95% CrI: 0.69, 0.93) for men and 0.97 (95% CrI: 0.88, 1.10) and 0.95 (95% CrI: 0.80, 1.17) for women. In conclusion, data from the JACC study provided strong evidence that daily milk intake among Japanese men was associated with delayed and lower risk of mortality from stroke especially cerebral infarction.

DOI： 10.3390/nu12092743

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

Deshpande Aniruddha, Miller-Petrie Molly K., Lindstedt Paulina A., Baumann Mathew M., Johnson Kimberly B., Blacker Brigette F., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Adamu Abdu A., Adebayo Oladimeji M., Adedeji Isaac Akinkunmi, Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhikari Tara Ballav, Afarideh Mohsen, Agudelo-Botero Marcela, Ahmadi Mehdi, Ahmadi Keivan, Ahmed Muktar Beshir, Ahmed Anwar E., Akalu Temesgen Yihunie, Akanda Ali S., Alahdab Fares, Al-Aly Ziyad, Alam Samiah, Alam Noore, Alamene Genet Melak, Alanzi Turki M., Albright James, Albujeer Ammar, Alcalde-Rabanal Jacqueline Elizabeth, Alebel Animut, Alemu Zewdie Aderaw, Ali Muhammad, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Amul Gianna Gayle Herrera, Andrei Catalina Liliana, Anjomshoa Mina, Ansariadi Ansariadi, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Asmelash Daniel, Atalay Hagos Tasew, Athari Seyyede Masoume, Athari Seyyed Shamsadin, Atre Sachin R., Ausloos Marcel, Awasthi Shally, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azman Andrew S., Babaee Ebrahim, Badawi Alaa, Bagherzadeh Mojtaba, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barboza Miguel A., Barnighausen Till Winfried, Basu Sanjay, Vo Dinh Bay, Bayati Mohsen, Bedi Neeraj, Beheshti Mahya, Behzadifar Meysam, Behzadifar Masoud, Ramirez Diana Fernanda Bejarano, Bell Michelle L., Bennett Derrick A., Benzian Habib, Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Bin Sayeed Muhammad Shahdaat, Biswas Raaj Kishore, Bohlouli Somayeh, Boufous Soufiane, Brady Oliver J., Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Brown Alexandria, Nagaraja Sharath Burugina, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Rincon Julio Cesar Campuzano, Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Cerin Ester, Chalise Binaya, Chattu Vijay Kumar, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Cromwell Elizabeth A., Dadi Abel Fekadu Fekadu, Dahiru Tukur, Dahlawi Saad M. A., Dandona Rakhi, Dandona Lalit, Dang Anh Kim, Daoud Farah, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davila-Cervantes Claudio Alberto, Weaver Nicole Davis, De la Hoz Fernando Pio, De Neve Jan-Walter, Demissie Dereje Bayissa, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Hoa Thi, Dolecek Christiane, Doyle Kerrie E., Dubljanin Eleonora, Duraes Andre Rodrigues, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, Zaki Maysaa El Sayed, El Tantawi Maha, Elhabashy Hala Rashad, El-Jaafary Shaimaa I, El-Khatib Ziad, Elkout Hajer, Elsharkawy Aisha, Enany Shymaa, Endalew Daniel Adane, Eshrati Babak, Eskandarieh Sharareh, Etemadi Arash, Ezekannagha Oluchi, Faraon Emerito Jose A., Fareed Mohammad, Faro Andre, Farzadfar Farshad, Fasil Alebachew Fasil, Fazlzadeh Mehdi, Feigin Valery L., Fekadu Wubalem, Fentahun Netsanet, Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Flohr Carsten, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Frostad Joseph Jon, Fukumoto Takeshi, Gad Mohamed M., Garcia Gregory M., Gatotoh Augustine Mwangi, Gayesa Reta Tsegaye, Gebremedhin Ketema Bizuwork, Geramo Yilma Chisha Dea, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghashghaee Ahmad, Sherbaf Farzaneh Ghazi, Gill Tiffany K., Gill Paramjit Singh, Ginindza Themba G., Girmay Alem, Gizaw Zemichael, Goodridge Amador, Gopalani Sameer Vali, Goulart Barbara Niegia Garcia, Goulart Alessandra C., Grada Ayman, Green Manfred S., Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Gupta Rahul, Ha Giang Hai, Haagsma Juanita A., Hafezi-Nejad Nima, Haile Dessalegn H., Haile Michael Tamene, Hall Brian J., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I, Hasan Mehedi, Hasanzadeh Amir, Hassen Hamid Yimam, Hayelom Desta Haftu, Hegazy Mohamed I, Heibati Behzad, Heidari Behnam, Hendrie Delia, Henok Andualem, Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Chi Linh Hoang, Hollerich Gillian I, Hoogar Praveen, Hossain Naznin, Hosseinzadeh Mehdi, Househ Mowafa, Hu Guoqing, Humayun Ayesha, Hussain Syed Ather, Hussen Mamusha Aman A., Ibitoye Segun Emmanuel, Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Ivers Rebecca Q., Iwu Chinwe Juliana, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jenabi Ensiyeh, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kanchan Tanuj, Karch Andre, Karki Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Kebede Mihiretu M., Keiyoro Peter Njenga, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Nuruzzaman, Khatab Khaled, Khater Mona M., Khater Amir M., Khayamzadeh Maryam, Khazaei Mohammad, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Sezer, Kisa Adnan, Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Krishan Kewal, Defo Barthelemy Kuate, Kugbey Nuworza, Kumar Pushpendra, Kumar G. Anil, Kumar Manasi, Kusuma Dian, La Vecchia Carlo, Lacey Ben, Lal Aparna, Lal Dharmesh Kumar, Lam Hilton, Lami Faris Hasan, Lansingh Van Charles, Lasrado Savita, Lebedev Georgy, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Lewycka Sonia, Li Shanshan, Linn Shai, Liu Shiwei, Lopez Jaifred Christian F., Lopukhov Platon D., Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Nasab Entezar Mehrabi, Mehta Kala M., Mekonnen Teferi, Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Meles Hagazi Gebre, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Metekiya Workua Mekonnen, Miazgowski Bartosz, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohammad Yousef, Mohammad Dara K., Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammed Shafiu, Mohammed Jemal Abdu, Mohammed Hassen, Mohebi Farnam, Mokdad Ali H., Moodley Yoshan, Moradi Masoud, Moradi Ghobad, Moradi-Joo Mohammad, Moraga Paula, Morales Linda, Mosapour Abbas, Mosser Jonathan F., Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Munro Sandra B., Muriithi Moses K., Murray Christopher J. L., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naghavi Mohsen, Naik Gurudatta, Nangia Vinay, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Cuong Tat Nguyen, Huong Lan Thi Nguyen, Nguyen QuynhAnh P., Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Norheim Ole F., Noubiap Jean Jacques, Oancea Bogdan, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olusanya Jacob Olusegun, Olusanya Bolajoko Olubukunola, Onwujekwe Obinna E., Ortega-Altamirano Doris V, Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Pana Adrian, Park Eun-Kee, Patel Sangram Kishor, Pathak Ashish, Patle Ajay, Paulos Kebreab, Pepito Veincent Christian Filipino, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Pesudovs Konrad, Pham Hai Quang, Pigott David M., Pilgrim Thomas, Pirsaheb Meghdad, Poljak Mario, Pollock Ian, Postma Maarten J., Pourmalek Farshad, Pourshams Akram, Prada Sergio I, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Rabiee Mohammad, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi Siavash, Rahimi-Movaghar Vafa, Rahman Muhammad Aziz, Rahman Mohammad Hifz Ur, Rajati Fatemeh, Ranabhat Chhabi Lal, Rao Puja C., Rasella Davide, Rath Goura Kishor, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Remuzzi Giuseppe, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Roever Leonardo, Ronfani Luca, Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabour Siamak, Sadeghi Ehsan, Moghaddam Sahar Saeedi, Safari Yahya, Sagar Rajesh, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Saleem Ahsan, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santos Itamar S., Santric-Milicevic Milena M., Sao Jose Bruno Piassi, Saraswathy Sivan Yegnanarayana Iyer, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Satpathy Maheswar, Sawhney Monika, Sayyah Mehdi, Sbarra Alyssa N., Schaeffer Lauren E., Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shafieesabet Azadeh, Shaheen Amira A., Shahid Izza, Shaikh Masood Ali, Shalash Ali S., Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharma Rajesh, Sheikh Aziz, Shetty B. Suresh Kumar, Shiferaw Wondimeneh Shibabaw, Shigematsu Mika, Shin Jae Il, Shiri Rahman, Shirkoohi Reza, Shivakumar K. M., Si Si, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Virendra, Singh Narinder Pal, Singh Balbir Bagicha Singh, Singh Jasvinder A., Singh Ambrish, Sinha Dhirendra Narain, Sisay Malede Mequanent, Skiadaresi Eirini, Smith David L., Filho Adauto Martins Soares, Sobhiyeh Mohammad Reza, Sokhan Anton, Soriano Joan B., Sorrie Muluken Bekele, Soyiri Ireneous N., Spurlock Emma Elizabeth, Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Taye Bineyam, Tefera Yonatal Mesfin, Tehrani-Banihashemi Arash, Tekelemedhin Shishay Wahdey, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, ThekkePurakkal Akhil Soman, Thomas Nihal, Thompson Robert L., Thomson Alan J., Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Bach Xuan Tran, Khanh Bao Tran, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uthman Olalekan A., Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Veisani Yousef, Violante Francesco S., Vollmer Sebastian, Whawariat Feleke Gebremeskel, Waheed Yasir, Wallin Mitchell Taylor, Wang Yuan-Pang, Wang Yafeng, Wangdi Kinley, Weiss Daniel J., Weldesamuel Girmay Teklay, Werkneh Adhena Ayaliew, Westerman Ronny, Wiangkham Taweewat, Wiens Kirsten E., Wijeratne Tissa, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yaseri Mehdi, Yatsuya Hiroshi, Yeshaneh Alex, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Younis Mustafa Z., Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Moghadam Telma Zahirian, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zar Heather J., Zerfu Taddese Alemu, Zhang Yunquan, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I, Reiner Robert C. Jr.

LANCET GLOBAL HEALTH Vol. 8 ( 9 ) page： E1162 - E1185 2020.9

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 Reviewed International coauthorship

Aniruddha Deshpande, Molly K. Miller-Petrie, Paulina A. Lindstedt, Mathew M. Baumann, Kimberly B. Johnson, Brigette F. Blacker, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Ayenew Negesse Abejie, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, Manfred Mario Kokou Accrombessi, Abdu A. Adamu, Oladimeji M. Adebayo, Isaac Akinkunmi Adedeji, Rufus Adesoji Adedoyin, Victor Adekanmbi, Olatunji O. Adetokunboh, Tara Ballav Adhikari, Mohsen Afarideh, Marcela Agudelo-Botero, Mehdi Ahmadi, Keivan Ahmadi, Muktar Beshir Ahmed, Anwar E. Ahmed, Temesgen Yihunie Akalu, Ali S. Akanda, Fares Alahdab, Ziyad Al-Aly, Samiah Alam, Noore Alam, Genet Melak Alamene, Turki M. Alanzi, James Albright, Ammar Albujeer, Jacqueline Elizabeth Alcalde-Rabanal, Animut Alebel, Zewdie Aderaw Alemu, Muhammad Ali, Mehran Alijanzadeh, Vahid Alipour, Syed Mohamed Aljunid, Ali Almasi, Amir Almasi-Hashiani, Hesham M. Al-Mekhlafi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Saeed Amini, Arianna Maever L. Amit, Gianna Gayle Herrera Amul, Catalina Liliana Andrei, Mina Anjomshoa, Ansariadi Ansariadi, Carl Abelardo T. Antonio, Benny Antony, Ernoiz Antriyandarti, Jalal Arabloo, Hany Mohamed Amin Aref, Olatunde Aremu, Bahram Armoon, Amit Arora, Krishna K. Aryal, Afsaneh Arzani, Mehran Asadi-Aliabadi, Daniel Asmelash, Hagos Tasew Atalay, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Sachin R. Atre, Marcel Ausloos, Shally Awasthi, Nefsu Awoke, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Andrew S. Azman, Ebrahim Babaee, Alaa Badawi, Mojtaba Bagherzadeh, Shankar M. Bakkannavar, Senthilkumar Balakrishnan, Maciej Banach, Joseph Adel Mattar Banoub, Aleksandra Barac, Miguel A. Barboza, Till Winfried Barnighausen, Sanjay Basu, Vo Dinh Bay, Mohsen Bayati, Neeraj Bedi, Mahya Beheshti, Meysam Behzadifar, Masoud Behzadifar, Diana Fernanda Bejarano Ramirez, Michelle L. Bell, Derrick A. Bennett, Habib Benzian, Dessalegn Ajema Berbada, Robert S. Bernstein, Anusha Ganapati Bhat, Krittika Bhattacharyya, Soumyadeep Bhaumik, Zulfiqar A. Bhutta, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Raaj Kishore Biswas, Somayeh Bohlouli, Soufiane Boufous, Oliver J. Brady, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Alexandria Brown, Sharath Burugina Nagaraja, Zahid A. Butt, Luis Alberto Camera, Ismael R. Campos-Nonato, Julio Cesar Campuzano Rincon, Jorge Cano, Josip Car, Rosario Cardenas, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ester Cerin, Binaya Chalise, Vijay Kumar Chattu, Ken Lee Chin, Devasahayam J. Christopher, Dinh-Toi Chu, Natalie Maria Cormier, Vera Marisa Costa, Elizabeth A. Cromwell, Abel Fekadu Fekadu Dadi, Tukur Dahiru, Saad M. A. Dahlawi, Rakhi Dandona, Lalit Dandona, Anh Kim Dang, Farah Daoud, Aso Mohammad Darwesh, Amira Hamed Darwish, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Aditya Prasad Dash, Claudio Alberto Davila-Cervantes, Nicole Davis Weaver, Fernando Pio De la Hoz, Jan-Walter De Neve, Dereje Bayissa Demissie, Gebre Teklemariam Demoz, Edgar Denova-Gutierrez, Kebede Deribe, Assefa Desalew, Samath Dhamminda Dharmaratne, Preeti Dhillon, Meghnath Dhimal, Govinda Prasad Dhungana, Daniel Diaz, Isaac Oluwafemi Dipeolu, Hoa Thi, Christiane Dolecek, Kerrie E. Doyle, Eleonora Dubljanin, Andre Rodrigues Duraes, Hisham Atan Edinur, Andem Effiong, Aziz Eftekhari, Nevine El Nahas, Maysaa El Sayed Zaki, Maha El Tantawi, Hala Rashad Elhabashy, Shaimaa El-Jaafary, Ziad El-Khatib, Hajer Elkout, Aisha Elsharkawy, Shymaa Enany, Daniel Adane Endalew, Babak Eshrati, Sharareh Eskandarieh, Arash Etemadi, Oluchi Ezekannagha, Emerito Jose A. Faraon, Mohammad Fareed, Andre Faro, Farshad Farzadfar, Alebachew Fasil Fasil, Mehdi Fazlzadeh, Valery L. Feigin, Wubalem Fekadu, Netsanet Fentahun, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Carsten Flohr, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Masoud Foroutan, Richard Charles Franklin, Joseph Jon Frostad, Takeshi Fukumoto, Mohamed M. Gad, Gregory M. Garcia, Augustine Mwangi Gatotoh, Reta Tsegaye Gayesa, Ketema Bizuwork Gebremedhin, Yilma Chisha Dea Geramo, Hailay Abrha Gesesew, Kebede Embaye Gezae, Ahmad Ghashghaee, Farzaneh Ghazi Sherbaf, Tiffany K. Gill, Paramjit Singh Gill, Themba G. Ginindza, Alem Girmay, Zemichael Gizaw, Amador Goodridge, Sameer Vali Gopalani, Barbara Niegia Garcia Goulart, Alessandra C. Goulart, Ayman Grada, Manfred S. Green, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Davide Guido, Rafael Alves Guimaraes, Yuming Guo, Rajeev Gupta, Rahul Gupta, Giang Hai Ha, Juanita A. Haagsma, Nima Hafezi-Nejad, Dessalegn H. Haile, Michael Tamene Haile, Brian J. Hall, Samer Hamidi, Demelash Woldeyohannes Handiso, Hamidreza Haririan, Ninuk Hariyani, Ahmed Hasaballah, Mehedi Hasan, Amir Hasanzadeh, Hamid Yimam Hassen, Desta Haftu Hayelom, Mohamed Hegazy, Behzad Heibati, Behnam Heidari, Delia Hendrie, Andualem Henok, Claudiu Herteliu, Fatemeh Heydarpour, Hagos Degefa de Hidru, Thomas R. Hird, Chi Linh Hoang, Gillian Hollerich, Praveen Hoogar, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Guoqing Hu, Ayesha Humayun, Syed Ather Hussain, Mamusha Aman A. Hussen, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Usman Iqbal, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Rebecca Q. Ivers, Chinwe Juliana Iwu, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Achala Upendra Jayatilleke, Ensiyeh Jenabi, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Zubair Kabir, Tanuj Kanchan, Andre Karch, Surendra Karki, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Habtamu Kebebe Kasaye, Gebrehiwot G. Kassa, Getachew Mullu Kassa, Gbenga A. Kayode, Mihiretu M. Kebede, Peter Njenga Keiyoro, Daniel Bekele Ketema, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Rovshan Khalilov, Ejaz Ahmad Khan, Junaid Khan, Nuruzzaman Khan, Khaled Khatab, Mona M. Khater, Amir M. Khater, Maryam Khayamzadeh, Mohammad Khazaei, Mohammad Hossein Khosravi, Jagdish Khubchandani, Ali Kiadaliri, Yun Jin Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Sonali Kochhar, Tufa Kolola, Hamidreza Komaki, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Pushpendra Kumar, G. Anil Kumar, Manasi Kumar, Dian Kusuma, Carlo La Vecchia, Ben Lacey, Aparna Lal, Dharmesh Kumar Lal, Hilton Lam, Faris Hasan Lami, Van Charles Lansingh, Savita Lasrado, Georgy Lebedev, Paul H. Lee, Kate E. LeGrand, Mostafa Leili, Tsegaye Lolaso Lenjebo, Cheru Tesema Leshargie, Aubrey J. Levine, Sonia Lewycka, Shanshan Li, Shai Linn, Shiwei Liu, Jaifred Christian F. Lopez, Platon D. Lopukhov, Muhammed Magdy Abd El Razek, D. R. Mahadeshwara Prasad, Phetole Walter Mahasha, Narayan B. Mahotra, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Chabila Christopher Mapoma, Gabriel Martinez, Santi Martini, Francisco Rogerlandio Martins-Melo, Manu Raj Mathur, Benjamin K. Mayala, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Man Mohan Mehndiratta, Entezar Mehrabi Nasab, Kala M. Mehta, Teferi Mekonnen, Tefera Chane Mekonnen, Gebrekiros Gebremichael Meles, Hagazi Gebre Meles, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Seid Tiku Mereta, Tuomo J. Meretoja, Tomislav Mestrovic, Workua Mekonnen Metekiya, Bartosz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Yousef Mohammad, Dara K. Mohammad, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Shafiu Mohammed, Jemal Abdu Mohammed, Hassen Mohammed, Farnam Mohebi, Ali H. Mokdad, Yoshan Moodley, Masoud Moradi, Ghobad Moradi, Mohammad Moradi-Joo, Paula Moraga, Linda Morales, Abbas Mosapour, Jonathan F. Mosser, Simin Mouodi, Seyyed Meysam Mousavi, Miliva Mozaffor, Sandra B. Munro, Moses K. Muriithi, Christopher J. L. Murray, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Mohsen Naghavi, Gurudatta Naik, Vinay Nangia, Bruno Ramos Nascimento, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Henok Biresaw Netsere, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, QuynhAnh P. Nguyen, Solomon Gedlu Nigatu, Dina Nur Anggraini Ningrum, Chukwudi A. Nnaji, Marzieh Nojomi, Ole F. Norheim, Jean Jacques Noubiap, Bogdan Oancea, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Jacob Olusegun Olusanya, Bolajoko Olubukunola Olusanya, Obinna E. Onwujekwe, Doris Ortega-Altamirano, Osayomwanbo Osarenotor, Frank B. Osei, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Smita Pakhale, Adrian Pana, Eun-Kee Park, Sangram Kishor Patel, Ashish Pathak, Ajay Patle, Kebreab Paulos, Veincent Christian Filipino Pepito, Norberto Perico, Aslam Pervaiz, Julia Moreira Pescarini, Konrad Pesudovs, Hai Quang Pham, David M. Pigott, Thomas Pilgrim, Meghdad Pirsaheb, Mario Poljak, Ian Pollock, Maarten J. Postma, Farshad Pourmalek, Akram Pourshams, Sergio Prada, Liliana Preotescu, Hedley Quintana, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Siavash Rahimi, Vafa Rahimi-Movaghar, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Fatemeh Rajati, Chhabi Lal Ranabhat, Puja C. Rao, Davide Rasella, Goura Kishor Rath, Salman Rawaf, Lal Rawal, Wasiq Faraz Rawasia, Giuseppe Remuzzi, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Leonardo Roever, Luca Ronfani, Enrico Rubagotti, Salvatore Rubino, Anas M. Saad, Siamak Sabour, Ehsan Sadeghi, Sahar Saeedi Moghaddam, Yahya Safari, Rajesh Sagar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Ahsan Saleem, Hosni Salem, Marwa Rashad Salem, Yahya Salimi, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Sivan Yegnanarayana Iyer Saraswathy, Nizal Sarrafzadegan, Benn Sartorius, Brijesh Sathian, Thirunavukkarasu Sathish, Maheswar Satpathy, Monika Sawhney, Mehdi Sayyah, Alyssa N. Sbarra, Lauren E. Schaeffer, David C. Schwebel, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Edson Servan-Mori, Azadeh Shafieesabet, Amira A. Shaheen, Izza Shahid, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Rajesh Sharma, Aziz Sheikh, B. Suresh Kumar Shetty, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Si Si, Soraya Siabani, Tariq Jamal Siddiqi, Diego Augusto Santos Silva, Virendra Singh, Narinder Pal Singh, Balbir Bagicha Singh Singh, Jasvinder A. Singh, Ambrish Singh, Dhirendra Narain Sinha, Malede Mequanent Sisay, Eirini Skiadaresi, David L. Smith, Adauto Martins Soares Filho, Mohammad Reza Sobhiyeh, Anton Sokhan, Joan B. Soriano, Muluken Bekele Sorrie, Ireneous N. Soyiri, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Bryan L. Sykes, Rafael Tabares-Seisdedos, Takahiro Tabuchi, Degena Bahrey Tadesse, Ingan Ukur Tarigan, Bineyam Taye, Yonatal Mesfin Tefera, Arash Tehrani-Banihashemi, Shishay Wahdey Tekelemedhin, Merhawi Gebremedhin Tekle, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Fisaha Haile Tesfay, Zemenu Tadesse Tessema, Kavumpurathu Raman Thankappan, Akhil Soman ThekkePurakkal, Nihal Thomas, Robert L. Thompson, Alan J. Thomson, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Bhaskaran Unnikrishnan, Muhammad Shariq Usman, Olalekan A. Uthman, Benjamin S. Chudi Uzochukwu, Pascual R. Valdez, Santosh Varughese, Yousef Veisani, Francesco S. Violante, Sebastian Vollmer, Feleke Gebremeskel Whawariat, Yasir Waheed, Mitchell Taylor Wallin, Yuan-Pang Wang, Yafeng Wang, Kinley Wangdi, Daniel J. Weiss, Girmay Teklay Weldesamuel, Adhena Ayaliew Werkneh, Ronny Westerman, Taweewat Wiangkham, Kirsten E. Wiens, Tissa Wijeratne, Charles Shey Wiysonge, Haileab Fekadu Wolde, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Getasew Taddesse Worku, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Mehdi Yaseri, Hiroshi Yatsuya, Alex Yeshaneh, Mekdes Tigistu Yilma, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mustafa Z. Younis, Hebat-Allah Salah A. Yousof, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Heather J. Zar, Taddese Alemu Zerfu, Yunquan Zhang, Arash Ziapour, Sanjay Zodpey, Yves Miel H. Zuniga, Simon Hay, Robert C. Reiner

LANCET GLOBAL HEALTH Vol. 8 ( 9 ) page： E1162 - E1185 2020.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities.Methods We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs.Findings Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40.0% (95% uncertainty interval [UI] 39.4-40.7) to 50.3% (50.0-50.5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46.3% (95% UI 46.1-46.5) in 2017, compared with 28.7% (28.5-29.0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88.6% (95% UI 87.2-89.7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664-711) of the 1830 (1797-1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76.1% (95% UI 71.6-80.7) of countries from 2000 to 2017, and in 53.9% (50.6-59.6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017.Interpretation Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. Reviewed International journal

Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

Chest Vol. 158 ( 2 ) page： 797 - 807 2020.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. RESEARCH QUESTION: What are the risk factors for infection after EBUS-GS-TBB? STUDY DESIGN AND METHODS: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). RESULTS: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. INTERPRETATION: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.

DOI： 10.1016/j.chest.2020.02.025

Glycated haemoglobin (HbA1c) as a reliable option for detecting diabetes among the urban poor population in Bangladesh. Reviewed International coauthorship International journal

Chiang C, Aoyama A, Khalequzzaman M, Choudhury SR, Paul D, Rayna SE, Khan FA, Hirakawa Y, Iso H, Yatsuya H

European journal of public health Vol. 30 ( 4 ) page： 839 - 841 2020.8

Language：English Publishing type：Research paper (scientific journal)

Our previous epidemiological survey targeting urban slum dwellers in Bangladesh showed that the prevalence of diabetes defined by glycated haemoglobin (HbA1c) was higher than the national estimation, and higher in women than men. Subsequently, we conducted the oral glucose tolerance test (OGTT) and found that HbA1c values were consistent with the OGTT findings for detecting diabetes. Our findings indicated that HbA1c ≥6.5% was a rational cut-off, but the optimal HbA1c cut-off for this population might be lower than the internationally recommended threshold. Measuring HbA1c would be a reliable and feasible option for detecting diabetes among underprivileged population in developing countries.

DOI： 10.1093/eurpub/cky275

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

Wiens Kirsten E., Lindstedt Paulina A., Blacker Brigette F., Johnson Kimberly B., Baumann Mathew M., Schaeffer Lauren E., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Acharya Dilaram, Adabi Maryam, Adamu Abdu A., Adebayo Oladimeji M., Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhena Beyene Meressa, Afarideh Mohsen, Ahmad Sohail, Ahmadi Keivan, Ahmed Anwar E., Ahmed Muktar Beshir, Ahmed Rushdia, Akalu Temesgen Yihunie, Alahdab Fares, Al-Aly Ziyad, Alam Noore, Alam Samiah, Alamene Genet Melak, Alanzi Turki M., Alcalde-Rabanal Jacqueline Elizabeth, Ali Beriwan Abdulqadir, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Andrei Catalina Liliana, Anjomshoa Mina, Anoushiravani Amir, Ansari Fereshteh, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Atalay Hagos Tasew, Athari Seyyed Shamsadin, Athari Seyyede Masoume, Atre Sachin R., Ausloos Marcel, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azzopardi Peter S., Babaee Ebrahim, Babalola Tesleem Kayode, Badawi Alaa, Bairwa Mohan, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Bali Ayele Geleto, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barnighausen Till Winfried, Basaleem Huda, Basu Sanjay, Bay Vo Dinh, Bayati Mohsen, Baye Estifanos, Bedi Neeraj, Beheshti Mahya, Behzadifar Masoud, Behzadifar Meysam, Bekele Bayu Begashaw, Belayneh Yaschilal Muche, Bell Michelle L., Bennett Derrick A., Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhattarai Suraj, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Birihane Binyam Minuye, Biswas Raaj Kishore, Bohlouli Somayeh, Bojia Hunduma Amensisa, Boufous Soufiane, Brady Oliver J., Bragazzi Nicola Luigi, Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Nagaraja Sharath Burugina, Busse Reinhard, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Chanie Wagaye Fentahun, Chatterjee Pranab, Chattu Vijay Kumar, Chichiabellu Tesfaye Yitna, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Culquichicon Carlos, Daba Matiwos Soboka, Damiani Giovanni, Dandona Lalit, Dandona Rakhi, Dang Anh Kim, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davey Gail, Davila-Cervantes Claudio Alberto, Davis Adrian C., Davitoiu Dragos Virgil, De la Hoz Fernando Pio, Demis Asmamaw Bizuneh, Demissie Dereje Bayissa, Demissie Getu Debalkie, Demoz Gebre Teklemariam, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Deshpande Aniruddha, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Djalalinia Shirin, Doyle Kerrie E., Dubljanin Eleonora, Duko Bereket, Duraes Andre Rodrigues, Kalan Mohammad Ebrahimi, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, El Sayed Iman, Zaki Maysaa El Sayed, El Tantawi Maha, Elema Teshome Bekele, Elhabashy Hala Rashad, El-Jaafary Shaimaa I., Elkout Hajer, Elsharkawy Aisha, Elyazar Iqbal R. F., Endalamaw Aklilu, Endalew Daniel Adane, Eskandarieh Sharareh, Esteghamati Alireza, Esteghamati Sadaf, Etemadi Arash, Ezekannagha Oluchi, Fareed Mohammad, Faridnia Roghiyeh, Farzadfar Farshad, Fazlzadeh Mehdi, Feigin Valery L., Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Fukumoto Takeshi, Gad Mohamed M., Gayesa Reta Tsegaye, Gebre Teshome, Gebremedhin Ketema Bizuwork, Gebremeskel Gebreamlak Gebremedhn, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghadiri Keyghobad, Ghashghaee Ahmad, Ghimire Pramesh Raj, Gill Paramjit Singh, Gill Tiffany K., Ginindza Themba G., Gomes Nelson G. M., Gopalani Sameer Vali, Goulart Alessandra C., Goulart Barbara Niegia Garcia, Grada Ayman, Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Hafezi-Nejad Nima, Haile Dessalegn H., Hailu Gessessew Bugssa, Haj-Mirzaian Arvin, Haj-Mirzaian Arya, Hamadeh Randah R., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I., Hasan Md Mehedi, Hasanpoor Edris, Hasanzadeh Amir, Hassankhani Hadi, Hassen Hamid Yimam, Hegazy Mohamed I., Heibati Behzad, Heidari Behnam, Hendrie Delia, Henry Nathaniel J., Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Hoang Chi Linh, Rad Enayatollah Homaie, Hoogar Praveen, Hoseini Mohammad, Hossain Naznin, Hosseini Mostafa, Hosseinzadeh Mehdi, Househ Mowafa, Hsairi Mohamed, Hu Guoqing, Hussen Mohammedaman Mama, Ibitoye Segun Emmanuel, Igumbor Ehimario U., Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Iwu Chinwe Juliana, Izadi Neda, Jaca Anelisa, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kahsay Amaha, Kalani Hamed, Kanchan Tanuj, Matin Behzad Karami, Karch Andre, Karim Mohd Anisul, Karki Hamidreza Karimi-Sari Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasahun Yawukal Chane, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Karyani Ali Kazemi, Kebede Mihiretu M., Keiyoro Peter Njenga, Kelbore Abraham Getachew, Kengne Andre Pascal, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Md Nuruzzaman, Khan Muhammad Shahzeb, Khatab Khaled, Khater Amir M., Khater Mona M., Khayamzadeh Maryam, Khazaei Mohammad, Khazaei Salman, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Adnan, Kisa Sezer, Kissoon Niranjan, Shivakumar K. M., Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Kraemer Moritz U. G., Krishan Kewal, Kugbey Nuworza, Kumar G. Anil, Kumar Manasi, Kumar Pushpendra, Kusuma Vivek Kumar Dian, La Vecchia Carlo, Lacey Ben, Lad Sheetal D., Lal Dharmesh Kumar, Lam Felix, Lami Faris Hasan, Lamichhane Prabhat, Lansingh Van Charles, Lasrado Savita, Laxmaiah Avula, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Li Shanshan, Linn Shai, Liu Shiwei, Liu Simin, Lodha Rakesh, Longbottom Joshua, Lopez Jaifred Christian F., Abd El Razek Hassan Magdy, Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Manda Ana Laura, Manohar Narendar Dawani Dawanu, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Maravilla Joemer C., Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Masaka Anthony, Massenburg Benjamin Ballard, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Mehta Kala M., Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Miazgowski Bartosz, Mihretie Kebadnew Mulatu, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohamadi-Bolbanabad Amjad, Mohammad Dara K., Mohammad Karzan Abdulmuhsin, Mohammad Yousef, Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammadifard Noushin, Mohammed Jemal Abdu, Mohammed Shafiu, Mohebi Farnam, Mokdad Ali H., Molokhia Mariam, Monasta Lorenzo, Moodley Yoshan, Moore Catrin E., Moradi Ghobad, Moradi Masoud, Moradi-Joo Mohammad, Moradi-Lakeh Maziar, Moraga Paula, Morales Linda, Velasquez Ilais Moreno, Mosapour Abbas, Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Muchie Kindie Fentahun, Mulaw Getahun Fentaw, Munro Sandra B., Muriithi Moses K., Murray Christoper J. L., Murthy G. V. S., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Nabhan Ashraf F., Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naidoo Kovin S., Naik Gurudatta, Najafi Farid, Nangia Vinay, Nansseu Jobert Richie, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Nguyen Cuong Tat, Nguyen Huong Lan Thi, Nguyen Trang Huyen, Nigatu Dabere, Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Nong Vuong Minh, Norheim Ole F., Noubiap Jean Jacques, Motlagh Soraya Nouraei, Oancea Bogdan, Ogah Okechukwu Samuel, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olagunju Tinuke O., Olusanya Bolajoko Olubukunola, Olusanya Jacob Olusegun, Onwujekwe Obinna E., Oren Eyal, Ortega-Altamirano Doris V., Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Patel Sangram Kishor, Paternina-Caicedo Angel J., Pathak Ashish, Patton George C., Paudel Deepak, Paulos Kebreab, Pepito Veincent Christian Filipino, Pereira Alexandre, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Piroozi Bakhtiar, Pirsaheb Meghdad, Postma Maarten J., Pourjafar Hadi, Pourmalek Farshad, Pourshams Akram, Poustchi Hossein, Prada Sergio I., Prasad Narayan, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi-Movaghar Afarin, Rahimi-Movaghar Vafa, Rahman Mohammad Hifz Ur, Rahman Muhammad Aziz, Rahman Shafiur, Rajati Fatemeh, Rana Saleem Muhammad, Ranabhat Chhabi Lal, Rasella Davide, Rawaf David Laith, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Reta Melese Abate, Rezaei Negar, Rezai Mohammad Sadegh, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Rios-Blancas Maria, Roever Leonardo, Ronfani Luca, Roro Elias Merdassa, Ross Jennifer M., Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabde Yogesh Damodar, Sabour Siamak, Sadeghi Ehsan, Safari Yahya, Safari-Faramani Roya, Sagar Rajesh, Sahebkar Amirhossein, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Salamati Payman, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santric-Milicevic Milena M., Jose Bruno Piassi Sao, Saraswathy Sivan Yegnanarayana Iyer, Sarkar Kaushik, Sarker Abdur Razzaque, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Sawhney Monika, Saxena Sonia, Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shabaninejad Hosein, Shafieesabet Azadeh, Shaikh Masood Ali, Shalash Ali S., Shallo Seifadin Ahmed, Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharifi Hamid, Shehata Hatem Samir, Sheikh Aziz, Shetty B. Suresh Kumar, Shibuya Kenji, Shiferaw Wondimeneh Shibabaw, Shifti Desalegn Markos, Shigematsu Mika, Il Shin Jae, Shiri Rahman, Shirkoohi Reza, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Ambrish, Singh Jasvinder A., Singh Narinder Pal, Singh Virendra, Sisay Malede Mequanent, Skiadaresi Eirini, Sobhiyeh Mohammad Reza, Sokhan Anton, Soltani Shahin, Somayaji Ranjani, Soofi Moslem, Sorrie Muluken Bekele, Soyiri Ireneous N., Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sultana Marufa, Sunguya Bruno Fokas, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Tasew Aberash Abay, Tefera Yonatal Mesfin, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Belay, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, Thomas Nihal, Toma Alemayehu, Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Tran Bach Xuan, Tran Khanh Bao, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Violante Francesco S., Vollmer Sebastian, Hawariat Feleke Gebremeskel W., Waheed Yasir, Wallin Mitchell Taylor, Wang Yafeng, Wang Yuan-Pang, Weaver Marcia, Weji Bedilu Girma, Weldesamuel Girmay Teklay, Welgan Catherine A., Werdecker Andrea, Westerman Ronny, Wiangkham Taweewat, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Wu Ai-Min, Xu Gelin, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yatsuya Hiroshi, Yeshaneh Alex, Yilgwan Christopher Sabo, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Yoon Seok-Jun, Younis Mustafa Z., Yousefifard Mahmoud, Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zepro Nejimu Biza, Zerfu Taddese Alemu, Zhang Yunquan, Zhao Xiu-Ju George, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I., Reiner Robert C. Jr.

LANCET GLOBAL HEALTH Vol. 8 ( 8 ) page： 1038 - 1060 2020.8

安全衛生担当労働者における加熱式タバコの利用状況 Reviewed

厚生の指標 Vol. 67 ( 6 ) page： 23 - 28 2020.6

Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)

目的職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる

Habitual tub bathing and risks of incident coronary heart disease and stroke. Reviewed International journal

Tomohiko Ukai, Hiroyasu Iso, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

Heart (British Cardiac Society) Vol. 106 ( 10 ) page： 732 - 737 2020.5

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Tub bathing is considered to have a preventive effect against cardiovascular disease (CVD) by improving haemodynamic function. However, no prospective studies have investigated the long-term effects of tub bathing with regard to CVD risk. METHODS: A total of 30 076 participants aged 40-59 years with no history of CVD or cancer were followed up from 1990 to 2009. Participants were classified by bathing frequency: zero to two times/week, three to four times/week and almost every day. The HRs of incident CVD were estimated using Cox proportional hazards models after adjusting for traditional CVD risk factors and selected dietary factors. RESULTS: During 538 373 person-years of follow-up, we documented a total of 2097 incident cases of CVD, comprising 328 coronary heart diseases (CHDs) (275 myocardial infarctions and 53 sudden cardiac deaths) and 1769 strokes (991 cerebral infarctions, 510 intracerebral haemorrhages, 255 subarachnoid haemorrhages and 13 unclassified strokes). The multivariable HRs (95% CIs) for almost daily or every day versus zero to two times/week were 0.72 (0.62 to 0.84, trend p<0.001) for total CVD; 0.65 (0.45 to 0.94, trend p=0.065) for CHD; 0.74 (0.62 to 0.87, trend p=0.005) for total stroke; 0.77 (0.62 to 0.97, trend p=0.467) for cerebral infarction; and 0.54 (0.40 to 0.73, trend p<0.001) for intracerebral haemorrhage. No associations were observed between tub bathing frequency and risk of sudden cardiac death or subarachnoid haemorrhage. CONCLUSION: The frequency of tub bathing was inversely associated with the risk of CVD among middle-aged Japanese.

DOI： 10.1136/heartjnl-2019-315752

降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

内藤久雄, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

産業衛生学雑誌 Vol. 62 ( 臨増 ) page： 610 - 610 2020.5

内藤久雄, 袁媛, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

日本衛生学雑誌 Vol. 75 ( Suppl. ) page： S161 - S161 2020.3

トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 柳場由絵, 八谷寛, 上島通浩

産業衛生学雑誌 Vol. 62 ( 2 ) page： 105 - 105 2020.3

労働者の生活習慣指導のありかた特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合愛知職域コホート研究

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 Vol. 62 ( 2 ) page： 94 - 94 2020.3

Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Tetsushi Yoshikawa

Transplant infectious disease : an official journal of the Transplantation Society Vol. 22 ( 1 ) page： e13203 2020.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. METHODS: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. RESULTS: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P < .0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P = .0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P = .0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P = .0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. CONCLUSION: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

DOI： 10.1111/tid.13203

Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease. Reviewed

Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Junpei Yamamoto, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

Journal of epidemiology Vol. 30 ( 1 ) page： 37 - 45 2020.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. METHODS: The study design was a prospective cohort study. During 1995-1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45-74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. RESULTS: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93-1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. CONCLUSIONS: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.

DOI： 10.2188/jea.JE20180130

Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

Journal of atherosclerosis and thrombosis Vol. 27 ( 4 ) page： 363 - 374 2020

Language：English Publishing type：Research paper (scientific journal)

AIM: A positive association between non-high-density lipoprotein cholesterol (non-HDL-C) and coronary heart disease (CHD) has been established; however, associations between non-HDL-C and stroke subtypes have not been determined. METHODS: We conducted a prospective study of 30,554 individuals aged 40-69 yrs with no history of cardiovascular disease (CVD) in Japan. Sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of stroke subtypes and CHD were estimated according to quintiles of non-HDL-C, using Cox proportional hazard models adjusted for other established risk factors. RESULTS: We identified 1,705 stroke and 296 CHD events over a median 15 yrs of follow-up. The fractional polynomials analysis revealed a U-shaped association between non-HDL-C and stroke risk in men. When analyzed for stroke subtypes, the data revealed an inverse relationship between non-HDL-C and intracerebral hemorrhage (ICH), primarily with lobar ICH, and a positive association between non-HDL-C and large-artery occlusive infarction in men [adjusted HR 0.55 (95% CI, 0.35-0.87) and 2.05 (95% CI, 1.07-3.93) for the highest and lowest quintile of non-HDL-C, respectively]. The lowest risk of ICH in women was observed in the fourth quintile, and the lowest risk of embolic infarction was observed in the third quintile. In contrast, non-HDL-C was positively associated with CHD in both sexes. CONCLUSIONS: In Japanese men, lower non-HDL-C levels were associated with a decreased risk of large-artery occlusive infarction and an increased risk of ICH, particularly lobar ICH.

DOI： 10.5551/jat.50385

Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study. Reviewed

Naohito Tanabe, Nao Seki, Chika Horikawa, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Shigekazu Ukawa, Akiko Tamakoshi

Internal medicine (Tokyo, Japan) Vol. 59 ( 24 ) page： 3123 - 3130 2020

Language：English Publishing type：Research paper (scientific journal)

Objective The burden of death from pneumonia is expected to increase with the aging of the population, as has been observed in Japan. Depressive tendency, a common psychosocial sign, may be a risk factor for pneumonia due to its possible association with some immune dysfunction. This study aimed to clarify the association between depressive tendency and the risk of death from pneumonia. Methods A population-based cohort that consisted of 75,174 Japanese men and women was followed for a median of 19.1 years. Four psychological and behavioral symptoms (depressive symptoms) were used to evaluate depressive tendency. Results A total of 1,329 deaths from pneumonia were observed. Depressive symptoms were positively and dose-dependently associated with the risk of death from pneumonia (P<0.001 for trend), and subjects with ≥2 depressive symptoms showed a significantly elevated risk compared to those without any symptoms (multivariable hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.39-1.99). This association was not significantly affected by sex or age at baseline. The elevated risk was still significant even when subjects were limited to those without any medical histories. The excess risk was observed not only for death occurring within the first 10 years of follow-up (multivariable HR, 2.05; 95% CI, 1.51-2.78) but also for that occurring in the longer follow-up period (multivariable HR, 1.48; 95% CI, 1.18-1.85). Conclusion Depressive tendency may be a risk factor for death from pneumonia. Further studies using a more reliable tool for the evaluation of depressive state are necessary to confirm this relationship.

DOI： 10.2169/internalmedicine.5052-20

Cross-sectional association between working and depression prevalence in cancer survivors: a literature review Reviewed International journal

Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

Environmental and Occupational Health Practice Vol. 2 ( 1 ) page： n/a - n/a 2020

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Reviewed International journal

Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

The American journal of clinical nutrition Vol. 110 ( 6 ) page： 1449 - 1455 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. OBJECTIVES: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. METHODS: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. RESULTS: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. CONCLUSIONS: Seaweed intake was inversely associated with risk of ischemic heart disease.

DOI： 10.1093/ajcn/nqz231

Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Reviewed

Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

Journal of epidemiology Vol. 29 ( 12 ) page： 457 - 463 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

DOI： 10.2188/jea.JE20180124

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. Reviewed

Shigehisa Kajikawa, Naoyuki Imai, Shotaro Okachi, Hiroshi Yatsuya, Tomohide Souma, Toshikazu Watanabe, Yasuhiro Goto, Tomoyuki Minezawa, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

Nagoya journal of medical science Vol. 81 ( 4 ) page： 613 - 620 2019.11

Language：English Publishing type：Research paper (scientific journal)

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUS-GS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

DOI： 10.18999/nagjms.81.4.613

Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. Reviewed International coauthorship International journal

Crystal Man Ying Lee, Stephen Colagiuri, Mark Woodward, Edward W Gregg, Robert Adams, Fereidoun Azizi, Rafael Gabriel, Tiffany K Gill, Clicerio Gonzalez, Allison Hodge, David R Jacobs Jr Jr, Joshua J Joseph, Davood Khalili, Dianna J Magliano, Kirsten Mehlig, Roger Milne, Gita Mishra, Morgana Mongraw-Chaffin, Julie A Pasco, Masaru Sakurai, Pamela J Schreiner, Elizabeth Selvin, Jonathan E Shaw, Gary Wittert, Hiroshi Yatsuya, Rachel R Huxley

BMJ open diabetes research & care Vol. 7 ( 1 ) page： e000794 2019.10

Language：English Publishing type：Research paper (scientific journal)

Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results: Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions: In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

DOI： 10.1136/bmjdrc-2019-000794

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study Reviewed

Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

CANCER RESEARCH AND TREATMENT Vol. 51 ( 4 ) page： 1509 - 1517 2019.10

The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis. Reviewed International coauthorship International journal

Yan Zhang, Fangfang Hou, Jiexue Li, Haiying Yu, Lu Li, Shilian Hu, Guodong Shen, Hiroshi Yatsuya

Medicine Vol. 98 ( 42 ) page： e17513 2019.10

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. OBJECTIVE: The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. DATA SOURCE: We electronically searched PubMed, Embase, and Web of Science for articles reporting an association between weight fluctuation and all-cause mortality that were published before April 30, 2018. STUDY APPRAISAL AND SYNTHESIS METHODS: The methodological quality of each study was appraised using the modified Newcastle Ottawa Quality Assessment Scale. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled using random-effect models. Meta-regression approaches were also performed to explore sources of between-study heterogeneity. RESULTS: A total of 15 studies were eligible for the current meta-analysis. The pooled overall HR for all-cause mortality in the group with the greatest weight fluctuations compared with the most stable weight category was 1.45 (95% CI: 1.29-1.63). Considerable between-study heterogeneity was observed, some of which was partially explained by the different follow-up durations used by the included studies. Moreover, publication bias that inflated the risk of all-cause mortality was detected using Egger's test (P = .001). CONCLUSION: Weight fluctuation might be associated with an increased risk of all-cause mortality.

DOI： 10.1097/MD.0000000000017513

Differences between expected and actual length of sick leave attributable to occupational accidents. Reviewed

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能 Reviewed

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 Vol. 78回 page： 220 - 220 2019.10

メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

金子佳世, 八谷寛, 李媛英, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 青山温子

日本公衆衛生学会総会抄録集 Vol. 78回 page： 220 - 220 2019.10

Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed International journal

Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

Journal of epidemiology Vol. 29 ( 9 ) page： 325 - 333 2019.9

KATOH Yoshiji, OTA Atsuhiko, YATSUYA Hiroshi

Journal of Occupational Safety and Health Vol. 12 ( 3 ) page： 173 - 179 2019.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：National Institute of Occupational Safety and Health

For prevention of occupational accidents, the Labor Standards Inspection Offices evaluated the severity of the accidents based on the expected length of sick leave which was reported to the offices. Workers who met the accidents often take longer periods of sick leave than expected. We examined the excess of the length and their associations with the workers' characteristics. The subjects were 1,672 workers (1,204 men and 468 women) who met occupational accidents. 71.2% of the men and 63.9% of the women took longer periods of sick leave than expected. Men had longer expected (median: 30 days for men, 28 days for women) and actual length of sick leave (median: 50 days for men, 39 days for women) than women. The median rates of the actual sick leave periods to the expected ones were 1.38 for the men and 1.20 for the women. In men, working for the transportation/port industry, a company size of 100-299 employees, and an age of less than 30, were significantly associated with taking longer periods of sick leave than expected. The severity of occupational accidents may be underestimated if it is estimated by the expected sick leave length.

DOI： 10.2486/josh.JOSH-2019-0009-CHO

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05150&link_issn=&doc_id=20191002450005&doc_link_id=10.2486%2Fjosh.JOSH-2019-0009-CHO&url=https%3A%2F%2Fdoi.org%2F10.2486%2Fjosh.JOSH-2019-0009-CHO&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

エチオピア北部の公務員における糖尿病および前糖尿病の危険因子(Risk factors of diabetes and prediabetes among public employees in northern Ethiopia) International coauthorship

He Yupeng, Chiang Chifa, Gebremariam Lemlem W., Yatsuya Hiroshi, Hirakawa Yoshihisa, Aoyama Atsuko

国際保健医療 Vol. 34 ( 3 ) page： 140 - 141 2019.9

High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver. Reviewed International journal

Naito H, Yoshikawa-Bando Y, Yuan Y, Hashimoto S, Kitamori K, Yatsuya H, Nakajima T

Scientific reports Vol. 9 ( 1 ) page： 12514 - 12514 2019.8

Language：English Publishing type：Research paper (scientific journal)

Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory-Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

DOI： 10.1038/s41598-019-48973-w

Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. Reviewed International journal

Tomoko Kobayashi, Kazuyo Tsushita, Eri Nomura, Akiko Muramoto, Ayako Kato, Yukari Eguchi, Takeshi Onoue, Motomitsu Goto, Shigeki Muto, Hiroshi Yatsuya, Hiroshi Arima

Journal of diabetes science and technology Vol. 13 ( 4 ) page： 796 - 798 2019.7

Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study. Reviewed

Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Naohito Tanabe, Hiroyasu Iso, Akiko Tamakoshi

Journal of epidemiology Vol. 29 ( 6 ) page： 233 - 237 2019.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. METHODS: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. RESULTS: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour/day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours/day. A similar inverse association of pneumonia and walking (0.5 hours/day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours/day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). CONCLUSIONS: Regular walking for ≥1 hour/day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

DOI： 10.2188/jea.JE20170341

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010. Reviewed International journal

Harumitsu Suzuki, Aya Kadota, Nagako Okuda, Takehito Hayakawa, Nobuo Nishi, Yasuyuki Nakamura, Hisatomi Arima, Naoko Miyagawa, Atsushi Satoh, Naomi Miyamatsu, Masahiko Yanagita, Hiroshi Yatsuya, Zentaro Yamagata, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

Environmental health and preventive medicine Vol. 24 ( 1 ) page： 37 - 37 2019.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The gender-specific characteristics of individuals at an increased risk of developing depression currently remain unclear despite a higher prevalence of depression in women than in men. This study clarified socioeconomic and lifestyle factors associated with an increased risk of subclinical depression in general Japanese men and women. METHODS: Study participants were residents not receiving psychiatric treatments in 300 sites throughout Japan in 2010 (1152 men, 1529 women). Multivariable-adjusted odds ratios (OR) and 95% confidence intervals (95%CIs) for socioeconomic factors and lifestyle factors were calculated using a logistic regression analysis. RESULTS: Risk of depressive tendencies was significantly higher in men who were single and living alone (OR, 3.27; 95% CI, 1.56-6.88) than those married. The risk was significantly lower in women who were not working and aged ≥ 60 years (OR, 0.39; 95% CI, 0.22-0.68) and higher in men who were not working and aged < 60 years (OR, 3.57; 95%CI, 1.31-9.72) compared with those who were working. Current smoking was also associated with a significantly increased risk of depressive tendencies in women (OR, 2.96; 95% CI, 1.68-5.22) but not in men. CONCLUSIONS: Socioeconomic and lifestyle factors were associated with an increased risk of depressive tendencies in general Japanese. Related factors were different by sex.

DOI： 10.1186/s12199-019-0788-6

Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up. Reviewed

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

Catherine Owens Johnson, Minh Nguyen, Gregory A. Roth, Emma Nichols, Tahiya Alam, Degu Abate, Foad Abd-Allah, Ahmed Abdelalim, Haftom Niguse Abraha, Niveen Me Abu-Rmeileh, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Gina Agarwal, Sutapa Agrawal, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Fares Alahdab, Raghib Ali, Nelson Alvis-Guzman, Nahla Hamed Anber, Mina Anjomshoa, Jalal Arabloo, Antonio Arauz, Johan Arnlov, Amit Arora, Ashish Awasthi, Maciej Banach, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Sanjay Basu, Abate Bekele Belachew, Yaschilal Muche Belayneh, Derrick A. Bennett, Isabela M. Bensenor, Krittika Bhattacharyya, Belete Biadgo, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Zahid A. Butt, Lucero Cahuana-Hurtado, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Yazan Chaiah, Peggy Pei-Chia Chiang, Jee-Young J. Choi, Hanne Christensen, Dinh-Toi Chu, Monica Cortinovis, Albertino Antonio Moura Damasceno, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Kairat Davletov, Barbora De Courten, Vanessa De la Cruz-Gongora, Meaza Girma Degefa, Samath Dhamminda Dharmaratne, Daniel Diaz, Manisha Dubey, Eyasu Ejeta Duken, Dumessa Edessa, Matthias Endres, Emerito Jose A. Faraon, Farshad Farzadfar, Eduarda Fernandes, Florian Fischer, Luisa Sorio Flor, Morsaleh Ganji, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Birhanu Geta, Kebede Embaye Gezae, Paramjit Singh Gill, Elena V. Gnedovskaya, Hector Gomez-Dantes, Alessandra C. Goulart, Giuseppe Grosso, Yuming Guo, Rajeev Gupta, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Graeme J. Hankey, Hamid Yimam Hassen, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Nabeel A. Herial, Mohammad Ali Hosseini, Sorin Hostiuc, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Nader Jahanmehr, Mehdi Javanbakht, Ravi Prakash Jha, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Andre Karch, Narges Karimi, Hamidreza Karimi-Sari, Amir Kasaeian, Tesfaye Dessale Kassa, Hossein Kazemeini, Adane Teshome Kefale, Yousef Saleh Khader, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Daniel Kim, Yun Jin Kim, Adnan Kisa, Mika Kivimaki, Ai Koyanagi, Rita K. Krishnamurthi, G. Anil Kumar, Alessandra Lafranconi, Sarah Lewington, Shanshan Li, Warren David Lo, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Mark T. Mackay, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Navid Manafi, Mohammad Ali Mansournia, Man Mohan Mehndiratta, Varshil Mehta, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, Erkin M. Mirrakhimov, Bahram Mohajer, Yousef Mohammad, Milad Mohammadoo-Khorasani, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Yaser Mokhayeri, Ghobad Moradi, Lidia Morawska, Ilais Moreno Velasquez, Seyyed Meysam Mousavi, Oumer Sada S. Muhammed, Walter Muruet, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Bruno Ramos Nascimento, Ruxandra Irina Negoi, Cuong Tat Nguyen, Long Hoang Nguyen, Yirga Legesse Nirayo, Bo Norrving, Jean Jacques Noubiap, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T. Olagunju, Tinuke O. Olagunju, Mayowa Ojo Owolabi, Jeyaraj Durai Pandian, Shanti Patel, Norberto Perico, Michael A. Piradov, Suzanne Polinder, Maarten J. Postma, Hossein Poustchi, V. Prakash, Mostafa Qorbani, Alireza Rafiei, Fakher Rahim, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Muhammad Aziz Rahman, Cesar Reis, Giuseppe Remuzzi, Andre M. N. Renzaho, Stefano Ricci, Nicholas L. S. Roberts, Stephen R. Robinson, Leonardo Roever, Gholamreza Roshandel, Parisa Sabbagh, Hosein Safari, Saeed Safari, Saeid Safiri, Amirhossein Sahebkar, Saleh Salehi Zahabi, Abdallah M. Samy, Paola Santalucia, Itamar S. Santos, Joao Vasco Santos, Milena M. Santric Milicevic, Benn Sartorius, Arundhati R. Sawant, Aletta Elisabeth Schutte, Sadaf G. Sepanlou, Azadeh Shafieesabet, Masood Ali Shaikh, Mehran Shams-Beyranvand, Aziz Sheikh, Kevin N. Sheth, Kenji Shibuya, Mika Shigematsu, Min-Jeong Shin, Ivy Shiue, Soraya Siabani, Badr Hasan Sobaih, Luciano A. Sposato, Ipsita Sutradhar, P. A. Sylaja, Cassandra E. I. Szoeke, Braden James Te Ao, Mohamad-Hani Temsah, Omar Temsah, Amanda G. Thrift, Marcello Tonelli, Roman Topor-Madry, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Irfan Ullah, Olalekan A. Uthman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Narayanaswamy Venketasubramanian, Kia Vosoughi, Giang Thu Vu, Yasir Waheed, Elisabete Weiderpass, Kidu Gidey Weldegwergs, Ronny Westerman, Charles D. A. Wolfe, Dawit Zewdu Wondafrash, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Hiroshi Yatsuya, Ebrahim M. Yimer, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Mohammad Zamani, Afshin Zarghi, Yunquan Zhang, Sanjay Zodpey, Valery L. Feigin, Theo Vos, Christopher J. L. Murray

LANCET NEUROLOGY Vol. 18 ( 5 ) page： 439 - 458 2019.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016.Methods We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles.Findings In 2016, there were 5.5 million (95% UI 5.3 to 5.7) deaths and 116.4 million (111.4 to 121.4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36.2% (-39.3 to -33.6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34.2% (-37.2 to -31.5), also with decreases in all SDI quintiles. There were 13.7 million (12.7 to 14.7) new stroke cases in 2016. Global age-standardised incidence declined by 8.1% (-10.7 to -5.5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80.1 million (74.1 to 86.3) prevalent cases of stroke globally in 2016; 41.1 million (38.0 to 44.3) in women and 39.0 million (36.1 to 42.1) in men.Interpretation Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

DOI： 10.1016/S1474-4422(19)30034-1

Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

Journal of diabetes investigation Vol. 10 ( 3 ) page： 837 - 845 2019.5

Language：English Publishing type：Research paper (scientific journal)

AIMS/INTRODUCTION: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. METHODS: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. RESULTS: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. CONCLUSIONS: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

DOI： 10.1111/jdi.12930

Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II. Reviewed

Rie Hayashi, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

Circulation journal : official journal of the Japanese Circulation Society Vol. 83 ( 5 ) page： 1072 - 1079 2019.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). CONCLUSIONS: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

DOI： 10.1253/circj.CJ-18-0842

特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標愛知職域コホート

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 内藤久雄, 太田充彦, 玉腰浩司, 青山温子

産業衛生学雑誌 Vol. 61 ( 臨増 ) page： 321 - 321 2019.5

トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

那須民江, 王海蘭, 袁媛, 内藤久雄, 伊藤由起, 八谷寛, 上島通浩

産業衛生学雑誌 Vol. 61 ( 臨増 ) page： 332 - 332 2019.5

Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review. Reviewed International journal

Ota A, Fujisawa A, Kawada K, Yatsuya H

International journal of environmental research and public health Vol. 16 ( 8 ) 2019.4

Language：English Publishing type：Research paper (scientific journal)

Cancer patients' return-to-work rates in Japan and their methodological quality have been little reported. We conducted a systematic review to explore the recent return-to-work rates and to assess the methodological quality of the existing literature. We selected 13 papers (2 in English and 11 in Japanese) published between 2005 and 2017. The return-to-work rates ranged from 53.8% to 95.2%. Of the selected papers, 12 papers employed a cross-sectional design, possessing high risk of selection bias due to participant selection. A total of 8 papers did not fully report the subjects' sex, age, employment status at cancer diagnosis, cancer site, stage, and treatment, suggesting high risk of selection bias due to confounding variables. High or unclear risk of attrition bias due to incomplete outcome data was detected in 12 papers in which data on return to work were not collected from all participants. High risk of reporting bias due to selective outcome reporting was pointed out in 6 studies in which the subjects' employment status at return to work or the duration between cancer diagnosis and assessment of return to work was unclear. Future studies must reduce the risk of selection, attrition, and reporting biases for specifying accurate return-to-work rates.

DOI： 10.3390/ijerph16081461

Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0). Reviewed International coauthorship

Khine MT, Ota A, Gearhardt AN, Fujisawa A, Morita M, Minagawa A, Li Y, Naito H, Yatsuya H

Nutrients Vol. 11 ( 3 ) page： 687 - 687 2019.3

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The Yale Food Addiction Scale 2.0 (YFAS 2.0) is used for assessing food addiction (FA). Our study aimed at validating its Japanese version (J-YFAS 2.0). The subjects included 731 undergraduate students. Confirmatory factor analysis indicated the root-mean-square error of approximation, comparative fit index, Tucker–Lewis index, and standardized root-mean-square residual were 0.065, 0.904, 0.880, and 0.048, respectively, for a one-factor structure model. Kuder–Richardson α was 0.78. Prevalence of the J-YFAS 2.0-diagnosed mild, moderate, and severe FA was 1.1%, 1.2%, and 1.0%, respectively. High uncontrolled eating and emotional eating scores of the 18-item Three-Factor Eating Questionnaire (TFEQ R-18) (p < 0.001), a high Kessler Psychological Distress Scale score (p < 0.001), frequent desire to overeat (p = 0.007), and frequent snacking (p = 0.003) were associated with the J-YFAS 2.0-diagnosed FA presence. The scores demonstrated significant correlations with the J-YFAS 2.0-diagnosed FA symptom count (p < 0.01). The highest attained body mass index was associated with the J-YFAS 2.0-diagnosed FA symptom count (p = 0.026). The TFEQ R-18 cognitive restraint score was associated with the J-YFAS 2.0-diagnosed FA presence (p < 0.05) and symptom count (p < 0.001), but not with the J-YFAS 2.0-diagnosed FA severity. Like the YFAS 2.0 in other languages, the J-YFAS 2.0 has a one-factor structure and adequate convergent validity and reliability.

DOI： 10.3390/nu11030687

Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy. Reviewed International journal

Ohmiya N, Hotta N, Mitsufuji S, Nakamura M, Omori T, Maeda K, Okuda K, Yatsuya H, Tajiri H

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society Vol. 31 ( 2 ) page： 164 - 172 2019.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIM: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. METHODS: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. RESULTS: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. CONCLUSION: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.1111/den.13259

Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013. Reviewed International coauthorship

Cui M, Chiang C, Cui R, Honjo K, Yatsuya H, Watson BM, Ikerdeu E, Mita T, Madraisau S, Aoyama A, Iso H

Journal of epidemiology Vol. 29 ( 3 ) page： 97 - 103 2019.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. METHODS: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25-64 years. RESULTS: The age-adjusted mean BMI was 29.3 kg/m2 in men and 29.9 kg/m2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m2) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. CONCLUSION: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

DOI： 10.2188/jea.JE20170127

Sleep duration and risk of breast cancer: The JACC Study Reviewed

Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

BREAST CANCER RESEARCH AND TREATMENT Vol. 174 ( 1 ) page： 219 - 225 2019.2

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium Reviewed International coauthorship International journal

Inker L.A, Grams M.E, Levey A.S, Coresh J, Cirillo M, Collins J.F, Gansevoort R.T, Gutierrez O.M, Hamano T, Heine G.H, Ishikawa S, Jee S.H, Kronenberg F, Landray M.J, Miura K, Nadkarni G.N, Peralta C.A, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak M.G, Zhang L, van Zuilen A.D, Hallan S.I, Kovesdy C.P, Woodward M, Levin A, Astor B, Appel L, Greene T, Chen T, Chalmers J, Arima H, Perkovic V, Yatsuya H, Tamakoshi K, Li Y, Hirakawa Y, Matsushita K, Sang Y, Polkinghorne K, Chadban S, Atkins R, Djurdjev O, Liu L, Zhao M, Wang F, Wang J, Ebert N, Martus P, Tang M, Emrich I, Seiler S, Zawada A, Nally J, Navaneethan S, Schold J, Sarnak M, Katz R, Hiramoto J, Iso H, Yamagishi K, Umesawa M, Muraki I, Fukagawa M, Maruyama S, Hasegawa T, Fujii N, Wheeler D, Emberson J, Townend J, Brenner H, Sch{\"o}ttker B, Saum K.-U, Fox C, Hwang S.-J, K{\"o}ttgen A, Schneider M.P, Eckardt K.-U, Green J, Kirchner H.L, Chang A.R, Ho K, Ito S, Miyazaki M, Nakayama M, Yamada G, Irie F, Sairenchi T, Yano Y, Kotani K, Nakamura T, Kimm H, Mok Y, Chodick G, Shalev V, Wetzels J.F.M, Blankestijn P.J, van den Brand J, Kollerits B, Ritz E, Nitsch D, Roderick P, Fletcher A, Bottinger E, Ellis S.B, Nadukuru R, Ueshima H, Okayama A, Tanaka S, Okamura T, Kadota A, Kenealy T, Elley C.R, Drury P.L, Ohkubo T, Asayama K, Metoki H, Kikuya M, Nelson R.G, Knowler W.C, Bakker S.J, Hak E, Heerspink H.J.L, Brunskill N, Major R, Shepherd D, Medcalf J, Jassal S.K, Bergstrom J, Ix J.H, Barrett-Connor E, Kalantar-Zadeh K, Sumida K, Muntner P, Warnock D, McClellan W, de Zeeuw D, Brenner B, Ikram M.A, Hoorn E.J, Dehghan A, Carrero J.J, Gasparini A, Wettermark B, Elinder C.-G, Wong T.Y, Sabanayagam C, Cheng C.-Y, Visseren F.L.J, Evans M, Segelmark M, Stendahl M, Sch{\"o}n S, Tangri N, Sud M, Naimark D, Wen C.-P, Tsao C.-K, Tsai M.-K, Chen C.-H, Konta T, Hirayama A, Ichikawa K, Lannfelt L, Larsson A, A}rnl{\"o}v J, Bilo H.J.G, Landman G.W.D, van Hateren K.J.J, Kleefstra N, Coresh (Chair J, Hallan S, Ballew S.H, Chen J, Kwak L, Surapaneni A

American Journal of Kidney Diseases Vol. 73 ( 2 ) page： 206 - 217 2019.2

Language：English Publishing type：Research paper (scientific journal)

© 2018 National Kidney Foundation, Inc. Rationale & Objective: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design: Cross-sectional individual participant-level analyses in a global consortium. Setting & Study Populations: 17 CKD and 38 general population and high-risk cohorts. Selection Criteria for Studies: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. Data Extraction: Data were obtained and analyzed between July 2015 and January 2018. Analytical Approach: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. Results: The CKD cohorts (n = 254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n = 1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59 mL/min/1.73 m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30 mg/g). Limitations: Variations in study era, health care delivery system, typical diet, and laboratory assays. Conclusions: Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

DOI： 10.1053/j.ajkd.2018.08.013

Other Link： http://orcid.org/0000-0002-3283-8196

Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium Reviewed International coauthorship

Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

BMJ-BRITISH MEDICAL JOURNAL Vol. 364 2019.1

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

Valery L. Feigin, Emma Nichols, Tahiya Alam, Marlena S. Bannick, Ettore Beghi, Natacha Blake, William J. Culpepper, E. Ray Dorsey, Alexis Elbaz, Richard G. Ellenbogen, James L. Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L. James, Catherine Owens Johnson, Nicholas J. Kassebaum, Giancarlo Logroscino, Benoit Marin, W. Cliff Mountjoy-Venning, Minh Nguyen, Richard Ofori-Asenso, Anoop P. Patel, Marco Piccininni, Gregory A. Roth, Timothy J. Steiner, Lars Jacob Stovner, Cassandra E. I. Szoeke, Alice Theadom, Stein Emil Vollset, Mitchell Taylor Wallin, Claire Wright, Joseph Raymond Zunt, Nooshin Abbasi, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Victor Aboyans, Haftom Niguse Abraha, Dilaram Acharya, Abdu A. Adamu, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Jose C. Adsuar, Mohsen Afarideh, Sutapa Agrawal, Alireza Ahmadi, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Rufus Olusola Akinyemi, Nadia Akseer, Ayman Al-Eyadhy, Rustam Al-Shahi Salman, Fares Alahdab, Kefyalew Addis Alene, Syed Mohamed Aljunid, Khalid Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Carl Abelardo T. Antonio, Jalal Arabloo, Olatunde Aremu, Johan Arnlov, Hamid Asayesh, Rana Jawad Asghar, Hagos Tasew Atalay, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Tambe B. Ayuk, Alaa Badawi, Maciej Banach, Joseph Adel Mattar Banoub, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Bernhard T. Baune, Neeraj Bedi, Masoud Behzadifar, Meysam Behzadifar, Yannick Bejot, Bayu Begashaw Bekele, Abate Bekele Belachew, Derrick A. Bennett, Isabela M. Bensenor, Adugnaw Berhane, Mircea Beuran, Krittika Bhattacharyya, Zulfiqar A. Bhutta, Belete Biadgo, Ali Bijani, Nigus Bililign, Muhammad Shahdaat Bin Sayeed, Christopher Kynrint Blazes, Carol Brayne, Zahid A. Butt, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Mate Car, Rosario Cardenas, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Ester Cerin, Yazan Chaiah, Jung-Chen Chang, Irini Chatziralli, Peggy Pei-Chia Chiang, Hanne Christensen, Devasahayam J. Christopher, Cyrus Cooper, Paolo Angelo Cortesi, Vera M. Costa, Michael H. Criqui, Christopher Stephen Crowe, Albertino Antonio Moura Damasceno, Ahmad Daryani, Vanessa De la Cruz-Gongora, Fernando Pio De la Hoz, Diego De Leo, Meaza Girma Degefa, Gebre Teklemariam Demoz, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Mesfin Tadese Dinberu, Shirin Djalalinia, David Teye Doku, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, David Edvardsson, Ziad El-Khatib, Matthias Endres, Aman Yesuf Endries, Sharareh Eskandarieh, Alireza Esteghamati, Sadaf Esteghamati, Farzaneh Farhadi, Andre Faro, Farshad Farzadfar, Mohammad Hosein Farzaei, Batool Fatima, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Garumma Tolu Feyissa, Irina Filip, Florian Fischer, Takeshi Fukumoto, Morsaleh Ganji, Fortune Gbetoho Gankpe, Miguel A. Garcia-Gordillo, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Belayneh K. Gelaw, Johanna M. Geleijnse, Demeke Geremew, Kebede Embaye Gezae, Maryam Ghasemi-Kasman, Mahari Y. Gidey, Paramjit Singh Gill, Tiffany K. Gill, Elena V. Gnedovskaya, Alessandra C. Goulart, Ayman Grada, Giuseppe Grosso, Yuming Guo, Rahul Gupta, Rajeev Gupta, Juanita A. Haagsma, Tekleberhan B. Hagos, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Yuantao Hao, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Andualem Henok, Fatemeh Heydarpour, Chi Linh Hoang, Michael K. Hole, Enayatollah Homaie Rad, Seyed Mostafa Hosseini, Guoqing Hu, Ehimario U. Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mihajlo Jakovljevic, Mehdi Javanbakht, Ravi Prakash Jha, Yash B. Jobanputra, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Manoochehr Karami, Andre Karch, Narges Karimi, Amir Kasaeian, Tesfaye Dessale Kassa, Zemenu Yohannes Kassa, Anil Kaul, Adane Teshome Kefale, Peter Njenga Keiyoro, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Habibolah Khazaie, Aliasghar A. Kiadaliri, Daniel N. Kiirithio, Anthony S. Kim, Daniel Kim, Young-Eun Kim, Yun Jin Kim, Adnan Kisa, Yoshihiro Kokubo, Ai Koyanagi, Rita V. Krishnamurthi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ben Lacey, Alessandra Lafranconi, Van C. Lansingh, Arman Latifi, Cheru Tesema Leshargie, Shanshan Li, Yu Liao, Shai Linn, Warren David Lo, Jaifred Christian F. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Robyn M. Lucas, Raimundas Lunevicius, Mark T. Mackay, Narayan Bahadur Mahotra, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Navid Manafi, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Winfried Marz, Tivani Phosa Mashamba-Thompson, Benjamin Ballard Massenburg, Kedar K. V. Mate, Colm McAlinden, John J. McGrath, Varshil Mehta, Toni Meier, Hagazi Gebre Meles, Addisu Melese, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Desalegn Tadese Mengistu, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Naser Mohammad Gholi Mezerji, Moslem Mohammadi, Maryam Mohammadi-Khanaposhtani, Roghayeh Mohammadibakhsh, Mousa Mohammadnia-Afrouzi, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Lorenzo Monasta, Stefania Mondello, Yoshan Moodley, Mahmood Moosazadeh, Ghobad Moradi, Maziar Moradi-Lakeh, Mehdi Moradinazar, Paula Moraga, Ilais Moreno Velasquez, Shane Douglas Morrison, Seyyed Meysam Mousavi, Oumer Sada Muhammed, Walter Muruet, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Gabriele Nagel, Aliya Naheed, Gurudatta Naik, Farid Najafi, Vinay Nangia, Ionut Negoi, Ruxandra Irina Negoi, Charles Richard James Newton, Josephine W. Ngunjiri, Cuong Tat Nguyen, Long Hoang Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Malihe Nourollahpour Shiadeh, Peter S. Nyasulu, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Tinuke O. Olagunju, Pedro R. Olivares, Obinna E. Onwujekwe, Eyal Oren, Mayowa Ojo Owolabi, P. A. Mahesh, Amir H. Pakpour, Wen-Harn Pan, Songhomitra Panda-Jonas, Jeyaraj Durai Pandian, Sangram Kishor Patel, David M. Pereira, Max Petzold, Julian David Pillay, Michael A. Piradov, Guilherme V. Polanczyk, Suzanne Polinder, Maarten J. Postma, Richie Poulton, Hossein Poustchi, Swayam Prakash, V. Prakash, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Fatemeh Rajati, Usha Ram, Anna Ranta, David Laith Rawaf, Salman Rawaf, Nickolas Reinig, Cesar Reis, Andre M. N. Renzaho, Serge Resnikoff, Shahab Rezaeian, Mohammad Sadegh Rezai, Carlos Miguel Rios Gonzalez, Nicholas L. S. Roberts, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Gholamreza Roshandel, Ali Rostami, Parisa Sabbagh, Ralph L. Sacco, Perminder S. Sachdev, Basema Saddik, Hosein Safari, Roya Safari-Faramani, Sare Safi, Saeid Safiri, Rajesh Sagar, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Payman Salamati, Saleh Salehi Zahabi, Yahya Salimi, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric Milicevic, Nizal Sarrafzadegan, Benn Sartorius, Shahabeddin Sarvi, Brijesh Sathian, Maheswar Satpathy, Arundhati R. Sawant, Monika Sawhney, Ione J. C. Schneider, Ben Schottker, David C. Schwebel, Soraya Seedat, Sadaf G. Sepanlou, Hosein Shabaninejad, Azadeh Shafieesabet, Masood Ali Shaikh, Raad A. Shakir, Mehran Shams-Beyranvand, Morteza Shamsizadeh, Mehdi Sharif, Mahdi Sharif-Alhoseini, Jun She, Aziz Sheikh, Kevin N. Sheth, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, Ivy Shiue, Soraya Siabani, Tariq J. Siddiqi, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Donald H. Silberberg, Joao Pedro Silva, Dayane Gabriele Alves Silveira, Jasvinder A. Singh, Dhirendra Narain Sinha, Eirini Skiadaresi, Mari Smith, Badr Hasan Sobaih, Soheila Sobhani, Moslem Soofi, Ireneous N. Soyiri, Luciano A. Sposato, Dan J. Stein, Murray B. Stein, Mark A. Stokes, Mu'awiyyah Babale Sufiyan, Bryan L. Sykes, Pn Sylaja, Rafael Tabares-Seisdedos, Braden James Te Ao, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Omar Temsah, Jarnail Singh Thakur, Amanda G. Thrift, Roman Topor-Madry, Miguel Tortajada-Girbes, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Lorainne Tudor Car, Kingsley Nnanna Ukwaja, Irfan Ullah, Muhammad Shariq Usman, Olalekan A. Uthman, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Yousef Veisani, Narayanaswamy Venketasubramanian, Francesco S. Violante, Vasily Vlassov, Kia Vosoughi, Giang Thu Vu, Isidora S. Vujcic, Fasil Shiferaw Wagnew, Yasir Waheed, Yuan-Pang Wang, Elisabete Weiderpass, Jordan Weiss, Harvey A. Whiteford, Tissa Wijeratne, Andrea Sylvia Winkler, Charles Shey Wiysonge, Charles D. A. Wolfe, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Yuichiro Yano, Mehdi Yaseri, Hiroshi Yatsuya, Ebrahim M. Yimer, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Zohreh Zare, Yunquan Zhang, Sanjay Zodpey, Mohsen Naghavi, Christopher J. L. Murray, Theo Vos

LANCET NEUROLOGY Vol. 18 ( 1 ) page： 56 - 87 2019.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247-308]) and second leading cause of deaths (9.0 million [8.8-9.4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34-44] and DALYs by 15% [9-21]) whereas their age-standardised rates decreased (deaths by 28% [26-30] and DALYs by 27% [24-31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42.2% [38.6-46.1]), migraine (16.3% [11.7-20.8]), Alzheimer's and other dementias (10.4% [9.0-124]), and meningitis (7.9% [6.6-10.4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1.12 [1.05-1.20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0.7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88.8% (86.5-90.9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22.3% [11.8-35.1] of DALYs are risk attributable) and idiopathic epilepsy (14.1% [10.8-17.5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Copyright (C) The Author(s). Published by Elsevier Ltd.

DOI： 10.1016/S1474-4422(18)30415-0

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) Reviewed International journal

Satoh Michihiro, Ohkubo Takayoshi, Asayama Kei, Murakami Yoshitaka, Sugiyama Daisuke, Yamada Michiko, Saitoh Shigeyuki, Sakata Kiyomi, Irie Fujiko, Sairenchi Toshimi, Ishikawa Shizukiyo, Kiyama Masahiko, Ohnishi Hirofumi, Miura Katsuyuki, Imai Yutaka, Ueshima Hirotsugu, Okamura Tomonori, Iso Hiroyasu, Kitamura Akihiko, Ninomiya Toshiharu, Kiyohara Yutaka, Nakagawa Hideaki, Nakayama Takeo, Okayama Akira, Sairenchi Toshimi, Tamakoshi Akiko, Tsuji Ichiro, Miyamoto Yoshihiro, Ishikawa Shizukiyo, Yatsuya Hiroshi, Okamura Tomonori

HYPERTENSION Vol. 73 ( 1 ) page： 52 - 59 2019.1

Language：English Publishing type：Research paper (scientific journal)

Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. The present metaanalysis included 107 737 Japanese (42.4% men; mean age, 55.1 years) from 13 cohorts. During the mean follow-up of 15.2±5.3 years (1 559 136 person-years), 1922 died from stroke and 913 from CHD. We estimated risks after adjusting for competing risk of death other than the outcome of interest. The 10-year risk of stroke and CHD deaths at index age of 35 years was ≤1.9% and ≤0.3%, respectively. The LTRs of stroke death at the index age of 35 years (men/women) were 6.1%/4.8% for optimal, 5.7%/6.3% for normal, and 6.6%/6.0% for high-normal blood pressure groups, and 9.1%/7.9% for grade 1, 14.5%/10.3% for grade 2, and 14.6%/14.3% for grade 3 hypertension groups. The LTRs of CHD death similarly elevated with an increase in blood pressure but were lower (≤7.2%) than those of stroke death. In conclusion, blood pressure was clearly associated with an elevated LTR of stroke or CHD death, although the LTR of CHD death was one-half of that of stroke death in an Asian population. These results would help young people with hypertension to adopt a healthy lifestyle or start antihypertensive therapy early.

DOI： 10.1161/HYPERTENSIONAHA.118.11635

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study Reviewed

Smoking results in accumulation of ectopic fat in the liver. Reviewed International journal

Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes, metabolic syndrome and obesity : targets and therapy Vol. 12 page： 1075 - 1079 2019

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

DOI： 10.2147/DMSO.S212495

Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS Vol. 26 ( 9 ) page： 775 - 782 2019

Smoking results in accumulation of ectopic fat in the liver. Reviewed

Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

Diabetes Metab Syndr Obes Vol. 9 ( 12 ) page： 1075 - 1080 2019

MULTICENTER FEASIBILITY STUDY OF BOWEL PREPARATION WITH CASTOR OIL FOR COLON CAPSULE ENDOSCOPY Reviewed International journal

OHMIYA Naoki, HOTTA Naoki, MITSUFUJI Shoji, NAKAMURA Masanao, OMORI Takafumi, MAEDA Kohei, OKUDA Kotaro, YATSUYA Hiroshi, TAJIRI Hisao

GASTROENTEROLOGICAL ENDOSCOPY Vol. 61 ( 12 ) page： 2646 - 2655 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Gastroenterological Endoscopy Society

Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster.Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged.Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P＜0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P=0.0048), male gender (adjusted OR, 3.20; P=0.0051), and use of castor oil (adjusted OR, 6.29; P=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively.Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

DOI： 10.11280/gee.61.2646

Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. Reviewed International journal

Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A

Pediatric transplantation Vol. 22 ( 7 ) page： e13239 2018.11

Language：English Publishing type：Research paper (scientific journal)

Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P = .041), PELD (OR 1.091; P = .038), and biliary atresia (OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

DOI： 10.1111/petr.13239

Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study Reviewed International coauthorship

Gebremariam Lemlem Weldegerima, Aoyama Atsuko, Kahsay Alemayehu Bayray, Hirakawa Yoshihisa, Chiang Chifa, Yatsuya Hiroshi, Matsuyama Akiko

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 451 - 464 2018.11

Language：English Publishing type：Research paper (scientific journal)

Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

DOI： 10.18999/nagjms.80.4.451

Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study Reviewed International coauthorship

Al-Shoaibi Abubakr Ahmed Abdullah, Matsuyama Akiko, Khalequzzaman Md, Haseen Fariha, Choudhury Sohel Reza, Hoque Bilqis Amin, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi, Aoyama Atsuko

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 559 - 569 2018.11

Language：English Publishing type：Research paper (scientific journal)

The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

DOI： 10.18999/nagjms.80.4.559

HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH Reviewed International coauthorship

Choudhury Sohel, Al-Shoaibi Abubakr Ahmed Abdullah, Khalequzzaman Mohammad, Al Mamun Mohammad Abdullah, Chiang Chifa, Yatsuya Hiroshi, Aoyama Atsuko

JOURNAL OF HYPERTENSION Vol. 36 page： E337 - E338 2018.10

Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Reviewed International journal

Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S, JPHC Study Group

Clinical nutrition (Edinburgh, Scotland) Vol. 37 ( 5 ) page： 1602 - 1608 2018.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND & AIMS: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. SUBJECTS/METHODS: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. RESULTS: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. CONCLUSIONS: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

DOI： 10.1016/j.clnu.2017.08.006

γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善愛知職域コホート Reviewed

金子佳世, 八谷寛, 李媛英, 上村真由, 江啓発, 平川仁尚, 太田充彦, 玉腰浩司, 豊嶋英明, 青山温子

日本公衆衛生学会総会抄録集 Vol. 77回 page： 204 - 204 2018.10

食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

日本公衆衛生学会総会抄録集 Vol. 77回 page： 322 - 322 2018.10

The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study. Reviewed International journal

Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Yoshihisa Hirakawa, Atsuhiko Ota, Mayu Uemura, Chifa Chiang, Rei Otsuka, Chiyoe Murata, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

Preventive medicine reports Vol. 11 page： 282 - 289 2018.9

Language：English Publishing type：Research paper (scientific journal)

The possible effects of a neighborhood's built environment on physical activity have not been studied in Asian countries as much as in Western countries. The present study cross-sectionally examined the relationship between geographic information system (GIS) measured residence and worksite neighborhood walkability, and the number of parks/green spaces and sports facilities within a 1 km radius of home and workplace, with self-reported leisure-time habitual (3-4 times per week or more) walking and moderate-to-vigorous intensity habitual exercise among local government workers aged 18 to 64 years living in an urban-suburban area of Aichi, Japan in 2013. A single-level binomial regression model was used to estimate the multivariable odds ratios (ORs) and 95% confidence intervals (95% CIs). Of the 1959 male and 884 female participants, 288 (15%) and 141 (16%) reported habitual walking, respectively, and 18% and 17% reported habitual exercise, respectively. Compared with women who resided in neighborhood with a walkability index of 4-30, those living in an area with that of 35-40 were significantly more likely to engage in leisure-time habitual exercise (multivariable OR: 1.70, 95% CI: 1.08-2.68). Marginally significant positive associations were found between leisure-time habitual exercise and the residential neighborhood's number of parks/green spaces among women, as well as the number of sports facilities among men. In conclusion, a residential neighborhood environment characterized by higher walkability may contribute to the initiation or maintenance of moderate-to-vigorous intensity leisure-time exercise among working women living in an urban-suburban area of Japan.

DOI： 10.1016/j.pmedr.2018.07.007

Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan Reviewed

Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tsuji I, Kiyama M, Miyamoto Y, Ishikawa S, Yatsuya H

Asian Pacific Journal of Cancer Prevention Vol. 19 ( 8 ) page： 2089 - 2095 2018.8

Language：English Publisher：Asian Pacific Journal of Cancer Prevention

© 2018 Asian Pacific Organization for Cancer Prevention. Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (< 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the

DOI： 10.22034/APJCP.2018.19.8.2089

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study Reviewed

Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients. Reviewed International journal

Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Tetsushi Yoshikawa

Transplant infectious disease : an official journal of the Transplantation Society Vol. 20 ( 4 ) page： e12916 2018.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. METHODS: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. RESULTS: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P = .0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P = .0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P = .0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P = .0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P = .0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. CONCLUSION: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

DOI： 10.1111/tid.12916

Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter? Reviewed International coauthorship International journal

Krisztina Gero, Hiroyasu Iso, Akihiko Kitamura, Kazumasa Yamagishi, Hiroshi Yatsuya, Akiko Tamakoshi

Preventive Medicine Vol. 113 page： 102 - 108 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Academic Press Inc.

We examined potential associations of sport club participation during adolescence and sports-related physical activity during adulthood with mortality from cardiovascular diseases (CVD) in a Japanese population. Between 1988 and 1990, 29,526 men and 41,043 women aged 40–79 years responded to a questionnaire including questions about the frequency of sports participation at baseline and sport club participation during junior/senior high school. Subjects were followed-up until the end of 2009, and 4230 cardiovascular deaths (870 CHD, 1859 stroke) were identified. Cox proportional-hazard regression models were used to estimate hazard ratios (HR). During the first-two thirds of the follow-up – where the proportional hazards assumption was met – the multivariate-adjusted HR (95% confidence interval) for total CVD mortality was 0.77 (0.61–0.98) among men and 0.82 (0.61–1.10) among women who were physically active at baseline (≥5 h/week versus 1–2 h/week). The corresponding HRs for coronary heart disease (CHD) mortality were 0.65 (0.39–1.07) and 0.40 (0.17–0.91), respectively. The combined associations of sports participation during adulthood and adolescence were also examined. Among men who participated in sports for ≥5 h/week at baseline, the multivariate-adjusted HR for those who also engaged in sport club activities during adolescence was 0.89 (0.61–1.30) for total CVD mortality and 0.24 (0.08–0.71) for CHD mortality when compared to non-participants. Among women, no statistically significant differences were found between sport club participants and non-participants. In conclusion, participating in sport clubs during adolescence might lead to a more pronounced risk-reduction for CHD mortality among men who also participate in sport activities during adulthood.

DOI： 10.1016/j.ypmed.2018.05.012

Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial Reviewed International journal

Akiko Fujisawa, Atsuhiko Ota, Masaaki Matsunaga, Yuanying Li, Masako Kakizaki, Hisao Naito, Hiroshi Yatsuya

Complementary Therapies in Clinical Practice Vol. 32 page： 6 - 11 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Churchill Livingstone

Objective: To examine whether laughter yoga (LY), i.e., simulated laughter, alters cortisol and dehydroepiandrosterone (DHEA) levels and cortisol/DHEA (C/D) ratios. Methods: In a randomized controlled trial, 120 healthy university students were allocated to experiencing LY, watching a comedy movie (spontaneous laughter), or reading a book. Salivary cortisol and DHEA levels were measured immediately before, immediately after, and 30 min after the intervention. Results: Cortisol levels and C/D ratios significantly decreased by time in the LY and comedy movie groups. Significant group*time interactions were found between these two groups for cortisol levels and C/D ratios. DHEA levels did not change by time in the LY group. Conclusions: LY decreased cortisol levels and C/D ratios but did not affect DHEA levels. Simulated and spontaneous laughter differently affected the dynamics of cortisol levels and C/D ratios. Effect of spontaneous laughter on the cortisol dynamics lasted longer than that of simulated laughter. (UMIN000019409).

DOI： 10.1016/j.ctcp.2018.04.005

Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia Reviewed International coauthorship International journal

Lemlem Weldegerima Gebremariam, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Alemayehu Bayray Kahsay, Hagos Godefay, Loko Abraham, Yoshihisa Hirakawa, Hiroyasu Iso, Atsuko Aoyama

Scientific Reports Vol. 8 ( 1 ) page： 9298 2018.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Publishing Group

The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41.0% were physically inactive, and 57.3% observed religious fast. The age-standardised prevalence of abdominal obesity was 29.3% in men and 58.5% in women, but that of metabolic syndrome was comparable between men (39.2%) and women (39.0%). The prevalence of diabetes was underestimated if only fasting blood glucose (FBG) was used for the diagnosis compared to combination of FBG and glycated haemoglobin (HbA1c) (6.7% in men and 3.8% in women vs. 12.1% in men and 5.6% in women). More than a quarter (26.1%) of men and 8.7% of women had estimated 10-year risk of cardiovascular disease of 10% or more. This study revealed the high prevalence of NCD metabolic risk factors among the urban public employees in the highland of Ethiopia.

DOI： 10.1038/s41598-018-27519-6

Aya Hirata, Daisuke Sugiyama, Makoto Watanabe, Akiko Tamakoshi, Hiroyasu Iso, Kazuhiko Kotani, Masahiko Kiyama, Michiko Yamada, Shizukiyo Ishikawa, Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Toshiharu Ninomiya, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group

Journal of Clinical Lipidology Vol. 12 ( 3 ) page： 674 - 684.e5 2018.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

Background: The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. Objective: We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. Methods: We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40–89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04–1.55 mmol/L (40–59 mg/dL) using a cohort-stratified Cox proportional hazards model. Results: During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to overall CVD were identified. Extremely high levels of HDL-C were significantly associated with increased risk of atherosclerotic CVD mortality (hazard ratio = 2.37, 95% confidence interval: 1.37–4.09 for total) and increased risk for coronary heart disease and ischemic stroke. In addition, the risk for extremely high HDL-C was more evident among current drinkers. Conclusion: We showed extremely high levels of HDL-C had an adverse effect on atherosclerotic CVD mortality in a pooled analysis of Japanese cohorts.

DOI： 10.1016/j.jacl.2018.01.014

降圧剤の投与は高血圧ラット肝臓Cyp7a1プロモーターのメチル化頻度を低下させる

内藤久雄, 三宅邦夫, 袁援, 橋本沙幸, 浅野友美, 北森一哉, 八谷寛, 那須民江

産業衛生学雑誌 Vol. 60 ( 臨増 ) page： 303 - 303 2018.5

Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study. Reviewed International journal

Shigekazu Ukawa, Akiko Tamakoshi, Mitsuru Mori, Satoyo Ikehara, Toru Shirakawa, Hiroshi Yatsuya, Hiroyasu Iso

Cancer causes & control : CCC Vol. 29 ( 2 ) page： 213 - 219 2018.2

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Seventy-five percent of epidemiological studies have reported that sedentary behavior is associated with ovarian cancer incidence. Although Japan has one of the most sedentary populations, with median sitting times of 7 h/day, this association has not been investigated. This study aimed to elucidate the association between average daily television (TV) viewing time, which is a major sedentary behavior, and the incidence of ovarian cancer in a large-scale nationwide cohort study in Japan. METHODS: A total of 34,758 female participants aged 40-79 years without a history of cancer at baseline were included in the study. The inverse probability weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the incidence of ovarian cancer. RESULTS: During a median follow-up of 19.4 years, 59 participants developed ovarian cancer (ICD-10: C56), 2,706 participants developed other types of cancer, and 4,318 participants died. Participants who watched TV for ≥ 5 h/day were more likely to develop ovarian cancer than those who watched TV for < 2 h/day (HR 2.15; 95% CI 1.54-2.99). CONCLUSION: Our findings suggest that reducing the amount of time spent sedentarily may be beneficial for preventing ovarian cancer.

DOI： 10.1007/s10552-018-1001-8

Relationships among Socioeconomic Factors and Self-rated Health in Japanese Adults: NIPPON DATA2010. Reviewed

Ota A, Yatsuya H, Nishi N, Okuda N, Ohkubo T, Hayakawa T, Kadota A, Okayama A, Miura K

Journal of epidemiology Vol. 28 ( Supplement_III ) page： S66 - S72 2018

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The distributions of socioeconomic status (SES) factors have been changing in Japan. We examined the relationships among SES and self-rated health (SRH) in Japanese adults. METHODS: We analyzed 1,178 men and 1,555 women. We showed the distribution of SRH by sex and age and examined cross-sectional relationships among educational attainment, marital/living statuses, working status, household income and expenditure, and fine SRH (defined as excellent, very good, or good). We adjusted for age, subjective symptoms, visiting doctors, monthly equivalent household expenditure (EHE), and living in their own house. RESULTS: The age-standardized prevalence of fine SRH was 79% and 73% among men and women, respectively. Among men, graduating from high school (adjusted odds ratio [aOR] 1.53; 95% confidence interval [CI], 1.07-2.19, relative to graduating from elementary or junior high school) and university or junior college (aOR 1.74; 95% CI, 1.15-2.62) was associated with fine SRH. Among women, graduating from university or junior college was associated with fine SRH (aOR 1.65; 95% CI, 1.12-2.46). Neither marital/living status nor working status was associated with SRH after adjustments for age in either sex. Among women, high EHE and income were associated with fine SRH (the highest expenditure group: aOR 1.80; 95% CI, 1.22-2.65; the highest income group: aOR 2.15; 95% CI, 1.34-3.46, relative to the corresponding lowest group). These simple relationships were not observed for men. CONCLUSIONS: High educational attainment was associated with fine SRH. Relationships among household income, EHE, and fine SRH differed by sex.

DOI： 10.2188/jea.JE20170246

A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study. Reviewed

Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A

Journal of epidemiology Vol. 28 ( 8 ) page： 347 - 352 2018

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men. METHODS: We followed 3,540 male participants of Aichi Workers' Cohort Study, who were aged 35-64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study's model. RESULTS: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects. CONCLUSION: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

DOI： 10.2188/jea.JE20170048

[Study on the probability of incident stroke and acute myocardial infarction using DPC data]. Reviewed

Masako Kakizaki, Norie Sawada, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Hiroyasu Iso, Shoichiro Tsugane, Hideo Yasunaga

[Nihon koshu eisei zasshi] Japanese journal of public health Vol. 65 ( 4 ) page： 179 - 186 2018

肥満と動脈硬化

八谷寛, 李媛英, 金子佳世, 太田充彦

食と医療 Vol. 4 page： 72 - 79 2018

Prevalence of non-communicable disease risk factors among poor shantytown residents in Dhaka, Bangladesh: a community-based cross-sectional survey. Reviewed International coauthorship International journal

Khalequzzaman M, Chiang C, Choudhury SR, Yatsuya H, Al-Mamun MA, Al-Shoaibi AAA, Hirakawa Y, Hoque BA, Islam SS, Matsuyama A, Iso H, Aoyama A

BMJ open Vol. 7 ( 11 ) page： e014710 2017.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. DESIGN: We conducted a community-based cross-sectional epidemiological study. SETTING: The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure. PARTICIPANTS: The study targeted residents aged 18-64 years. A total of 2986 eligible households with one eligible individual were selected by simple random sampling stratified by household wealth status. A total of 2551 residents completed the questionnaire survey, and 2009 participated in the subsequent physical and biochemical measurements. OUTCOME MEASURES: A modified WHO survey instrument was used for assessing behavioural risk factors and physical and biochemical measurements, including glycated haemoglobin (HbA1c). The prevalence of NCD risk factors, such as tobacco use, fruit and vegetable intake, overweight/obesity, hypertension, diabetes (HbA1c ≥6.5%) and dyslipidaemia, was described according to household wealth status and gender differences. RESULTS: The prevalence of current tobacco use was 60.4% in men and 23.5% in women. Most of them (90.8%) consumed more than 1 serving of fruits and vegetables per day; however, only 2.1% consumed more than 5 servings. Overweight/obesity was more common in women (39.2%) than in men (18.9%), while underweight was more common in men (21.0%) than in women (7.1%). The prevalence of hypertension was 18.6% in men and 20.7% in women. The prevalence of diabetes was 15.6% in men and 22.5% in women, which was much higher than the estimated national prevalence (7%). The prevalence of raised total cholesterol (≥190 mg/dL) was 25.7% in men and 34.0% in women. CONCLUSION: The study identified that tobacco use, both overweight and underweight, diabetes, hypertension and dyslipidaemia were prevalent among the urban poor in Bangladesh.

DOI： 10.1136/bmjopen-2016-014710

Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study Reviewed International journal

Toru Shirakawa, Kazumasa Yamagishi, Hiroshi Yatsuya, Naohito Tanabe, Akiko Tamakoshi, Hiroyasu Iso

ATHEROSCLEROSIS Vol. 266 page： 64 - 68 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Background and aims: Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases.
Methods: A total of 34,720 men from the Japan Collaborative Cohort study, aged 40-79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of <= 30 g, and > 30 g ethanol per day.
Results: During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of <= 30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28-0.76) for total aortic disease and 0.16 (0.05-0.50) for aortic dissection. Heavy drinkers of > 30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm.
Conclusions: Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men. (C) 2017 Published by Elsevier Ireland Ltd.

DOI： 10.1016/j.atherosclerosis.2017.08.025

Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study Reviewed International journal

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

ATHEROSCLEROSIS Vol. 265 page： 147 - 154 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Background and aims: Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations.
Methods: A prospective study was conducted among 30,736 individuals aged 40-69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors.
Results: We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00-2.66) in men and 1.97 (95% CI, 1.19-3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men.
Conclusions: The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.atherosclerosis.2017.08.032

Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan Reviewed International journal

Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A

Fujita Medical Journal Vol. 3 ( 3 ) page： 55 - 61 2017.8

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Fujita Medical Society

Objectives: This study investigated restrictions in functional capacity, self-rated health status (SRHS), and psychosocial characteristics of employed cancer survivors in Japan and examined differences in these characteristics between cancer survivors and employees without cancer history.Methods: A cross-sectional survey was carried out. Subjects were local government employees in Japan in 2013 (n=5,474). Using a self-administered questionnaire, we evaluated restrictions in functional capacity, SRHS, and the following psychosocial characteristics: social support, perceived stress, social capital, positive reasons for living (ikigai), and happiness. We examined whether cancer history was associated with restrictions in functional capacity, SRHS, and psychosocial characteristics.Results: A total of 112 employees were cancer survivors. Of these, males of all ages and comparatively younger females had restrictions in functional capacity more frequently than the corresponding subjects without cancer history (males of all ages: 14.5% vs. 2.9%, p<0.001; females <50 years: 15.2% vs. 1.1%, p<0.001). Among males of all ages, cancer survivors reported bad SRHS more frequently than employees without cancer history (8.1% vs. 1.5%, p=0.003). No significant differences were found in psychosocial characteristics by cancer history.Conclusions: Male and comparatively young female employed cancer survivors frequently experienced restrictions in functional capacity. Male employed cancer survivors self-rated their health status as bad more frequently than male employees without cancer history.

DOI： 10.20407/fmj.3.3_55

A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan Reviewed

Takumi Hirata, Daisuke Sugiyama, Shin-ya Nagasawa, Yoshitaka Murakami, Shigeyuki Saitoh, Akira Okayama, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Yoshihiro Miyamoto, Michiko Yamada, Shizukiyo Ishikawa, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Tomonori Okamura

European Journal of Epidemiology Vol. 32 ( 7 ) page： 547 - 557 2017.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Netherlands

Low levels of serum high-density lipoprotein cholesterol (HDL-C) have been shown to be associated with increased risk of coronary heart disease (CHD). However, because this is usually observed in the context of other lipid abnormalities, it is not known whether isolated low serum HDL-C levels are an independent risk factor for CHD. We performed a large pooled analysis in Japan using data from nine cohorts with 41,206 participants aged 40–89 years who were free of cardiovascular disease at baseline. We divided participants into three groups: isolated low HDL-C, non-isolated low HDL-C, and normal HDL-C. Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ischemic stroke, and intracranial cerebral hemorrhage
during a 12.9-year follow-up, we observed 355, 286, and 138 deaths, respectively, in these groups. Non-isolated low HDL-C was significantly associated with increased risk of CHD compared with normal HDL-C (HR 1.37, 95 % confidence interval (CI) 1.04–1.80)
however, isolated low HDL-C was not. Although isolated low HDL-C was significantly associated with decreased risk of CHD (HR 0.51, 95 % CI 0.29–0.89) in women, it was significantly associated with increased risk of intracranial cerebral hemorrhage in all participants (HR 1.62, 95 % CI 1.04–2.53) and in men (HR 2.00, 95 % CI 1.04–3.83). In conclusion, isolated low HDL-C levels are not associated with increased risk of CHD in Japan. CHD risk may, therefore, be more strongly affected by serum total cholesterol levels in this population.

DOI： 10.1007/s10654-016-0203-1

Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study Reviewed International coauthorship International journal

Jay H. Lubin, David Couper, Pamela L. Lutsey, Hiroshi Yatsuya

NICOTINE & TOBACCO RESEARCH Vol. 19 ( 7 ) page： 826 - 835 2017.7

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS

Cigarette smoking, various metabolic and lipid-related factors and hypertension are well-recognized cardiovascular disease (CVD) risk factors. Since smoking affects many of these factors, use of a single imprecise smoking metric, for example, ever or never smoked, may allow residual confounding and explain inconsistencies in current assessments of interactions.
Using a comprehensive model in pack-years and cigarettes/day for the complex smoking-related relative risk (RR) of CVD to reduce residual confounding, we evaluated interactions with non-tobacco risk factors, including additive (non-synergistic) and multiplicative (synergistic) forms. Data were from the prospective Atherosclerosis Risk in Communities (ARIC) Study from four areas of the United States recruited in 1987-1989 with follow-up through 2008. Analyses included 14 127 participants, 207 693 person-years and 2857 CVD events.
Analyses revealed distinct interactions with smoking: including statistical consistency with additive (body mass index [BMI], waist to hip ratio [WHR], diabetes mellitus [DM], glucose, insulin, high density lipoproteins [HDL] and HDL(2)); and multiplicative (hypertension, total cholesterol [TC], low density lipoproteins [LDLs], apolipoprotein B [apoB], TC to HDL ratio and HDL(3)) associations, as well as indeterminate (apolipoprotein A-I [apoA-I] and triglycerides) associations.
The forms of the interactions were revealing but require confirmation. Improved understanding of joint associations may help clarify the public health burden of smoking for CVD, links between etiologic factors and biological mechanisms, and the consequences of joint exposures, whereby synergistic associations highlight joint effects and non-synergistic associations suggest distinct contributions.
Joint associations for cigarette smoking and non-tobacco risk factors were distinct, revealing synergistic/multiplicative (hypertension, TC, LDL, apoB, TC/HDL, HDL(3)), non-synergistic/additive (BMI, WHR, DM, glucose, insulin, HDL, HDL(2)) and indeterminate (apoA-I and TRIG) associations. If confirmed, these results may help better define the public health burden of smoking on CVD risk and identify links between etiologic factors and biologic mechanisms, where synergistic associations highlight joint impacts and non-synergistic associations suggest distinct contributions from each factor.

DOI： 10.1093/ntr/ntw235

A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study Reviewed

Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

ATHEROSCLEROSIS Vol. 261 page： 124 - 130 2017.6

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Background and aims: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians.
Methods: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing- risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke). Population attributable fractions (PAFs) were also calculated for these endpoints to estimate the population impact of each risk factor.
Results: During a median 19.1-year follow-up, 1554 died from CHD and 3163 from stroke. The association of hypertension with CHD was similar to that with stroke in terms of the magnitude and direction (multivariable-adjusted hazard ratio for CHD: 1.63 vs. stroke: 1.73 in men and 1.70 vs. 1.66 in women). Conversely, the magnitude of these associations differed for smoking (CHD: 1.95 vs. stroke: 1.23 in men and 2.45 vs. 1.35 in women) and diabetes (1.49 vs. 1.09 in men and 2.08 vs. 1.39 in women). The highest PAF for CHD was caused by smoking in men and by hypertension in women; that for stroke was caused by hypertension in both sexes.
Conclusions: Hypertension associations and PAFs were consistent between CHD and stroke, but not for other risk factors. These findings may be useful to optimize public health intervention strategies. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.atherosclerosis.2017.03.003

Descriptive Epidemiology of Hypertension and Its Association With Obesity: Based on the WHO STEPwise Approach to Surveillance in Palau Reviewed International coauthorship International journal

Chaochen Wang, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Hiroyasu Iso, Atsuko Aoyama

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH Vol. 29 ( 4 ) page： 278 - 287 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE PUBLICATIONS INC

The rise of noncommunicable diseases is a serious health burden for Palau. This study described the prevalence of hypertension, and assessed its association with obesity. Surveys following the WHO STEPwise approach to surveillance were conducted in 2529 adults. Multivariate prevalence ratios (PR) of hypertension for body mass index (BMI) categories were calculated by logistic regression models using conditional standardization procedure. Age- and sex-specified analyses were performed. Overall prevalence of obesity and hypertension were 40.4% and 46.8%, respectively. Prevalence of hypertension was positively associated with BMI. However, overweight men had as high prevalence of hypertension as the obese (multivariable-adjusted PR was 1.84 for overweight and 1.91 for obese compared with nonoverweight). The association between hypertension and BMI was similar across age groups. The prevalence of hypertension in women increased gradually with the increase of BMI whereas that in men reached a plateau already in the overweight.

DOI： 10.1177/1010539517704042

Disparity in metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau Reviewed International coauthorship International journal

Ayaka Osako, Chifa Chiang, Kana Ito, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Gregorio Ngirmang, Hiroyasu Iso, Atsuko Aoyama

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 2 ) page： 157 - 165 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：NAGOYA UNIV, SCH MED

Non-communicable diseases have been recognized as a serious threat to public health in Palau. To tackle the problem, different strategies might be necessary for populations with different ethnic backgrounds. This study aims to find the differences in the prevalence of metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau, and examine possible determinants of the differences. We selected data of 2,032 participants, including native Palauans and Filipinos, from the Palau STEPS Survey 2011-2013 for this study. Logistic regression models were used to inspect the association of each metabolic risk factor with ethnicity by calculating odds ratios adjusted for potential confounding factors. Palauans had higher age-standardized prevalence of overweight or obesity (84% vs. 45%), hypertension (50% vs. 38%) and diabetes (19% vs. 13%) than Filipinos. However, after adjusting for BMI and various lifestyle related factors, there are no statistical significant differences in the prevalence of hypertension and diabetes between these two ethnic groups. Palauan men were less likely to have elevated total cholesterol, especially after adjusting for BMI (odds ratio=0.55, 95% confidence interval: 0.33-0.91), while Palauan women were more likely to have elevated triglycerides than their Filipino counterparts (odds ratio=1.45, 95% confidence interval: 1.02-2.06). Our findings suggested that Palauans' higher BMI distribution might be able to explain their higher prevalence of hypertension and partially explain their higher diabetes prevalence. Palauans were not consistently more likely to have all metabolic risk factors, namely dyslipidemia were less likely to be observed in Palauan men.

DOI： 10.18999/nagjms.79.2.157

Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study Reviewed International journal

Shigekazu Ukawa, Akiko Tamakoshi, Hiroshi Yatsuya, Kazumasa Yamagishi, Masahiko Ando, Hiroyasu Iso

INTERNATIONAL JOURNAL OF PUBLIC HEALTH Vol. 62 ( 4 ) page： 489 - 494 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER BASEL AG

To elucidate the association between passive smoking at home and chronic obstructive pulmonary disease (COPD) mortality via a large-scale nationwide cohort study in Japan.
Never smokers (n = 34,604) aged 40-79 years at baseline (1988-1990; 4884 men, 29,720 women) were included in the analysis. Passive smoking at home was measured based on self-reported frequency of weekly exposure to passive smoking at home. An inverse probability of treatment-weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for COPD mortality.
During a median follow-up of 16.4 years, 33 participants (10 men, 23 women) died of COPD. The HR for participants exposed to passive smoking at home ae<currency>4 days per week or those who had almost daily exposure to passive smoking at home had a significantly increased risk of COPD mortality (HR 2.40, 95% CI 1.39-4.15, HR 2.88, 95% CI 1.68-4.93, respectively).
The present findings suggest that avoiding passive smoking at home may be beneficial for preventing death due to COPD among never smokers.

DOI： 10.1007/s00038-016-0938-1

Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma Reviewed International journal

Sumito Isogai, Yoshikazu Niwa, Hiroshi Yatsuya, Masamichi Hayashi, Naoki Yamamoto, Takuya Okamura, Tomoyuki Minezawa, Yasuhiro Goto, Teppei Yamaguchi, Tomoko Takeyama, Yosuke Sakakibara, Sayako Morikawa, Tomoya Horiguchi, Yusuke Gotoh, Yuki Mieno, Sakurako Uozu, Toru Nakanishi, Mitsushi Okazawa, Hiroki Sakakibara, Kazuyoshi Imaizumi

ALLERGOLOGY INTERNATIONAL Vol. 66 ( 2 ) page： 360 - 362 2017.4

Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study Reviewed International journal

Y. Zhang, H. Yatsuya, Y. Li, C. Chiang, Y. Hirakawa, N. Kawazoe, K. Tamakoshi, H. Toyoshima, A. Aoyama

NUTRITION & DIABETES Vol. 7 ( 3 ) page： e252 2017.3

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women.
METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35-66 years and free of diabetes in 2002 were followed through 2014. Past body weights at the ages of 20, 25, 30, 40 years, and 5 years before baseline as well as measured body weight at baseline were regressed on the ages. Slope and root-mean-square-error of the regression line were obtained and used to represent the weight changes and the weight fluctuation, respectively. The associations of the weight-change slopes and the weight fluctuation with incident T2DM were estimated by Cox proportional hazards models.
RESULTS: During the median follow-up of 12.2 years, 400 incident cases of T2DM were documented. After adjustment for baseline overweight and other lifestyle covariates, the weight-change slopes were significantly associated with higher incidence of T2DM (hazard ratio (HR): 1.80, 95% confident interval (CI): 1.17-2.77 for men; and HR: 2.78, 95% CI: 1.07-7.23 for women), while the weight fluctuation was not (HR: 1.08, 95% CI: 1.00-1.18 for men and HR: 1.02, 95% CI: 0.84-1.25 for women).
CONCLUSIONS: Regardless of the presence of overweight, the long-term weight-change slopes were significantly associated with the increased risk of T2DM; however, the weight fluctuation was not associated with the risk of T2DM in middle-aged Japanese men and women.

DOI： 10.1038/nutd.2017.5

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke Reviewed

Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Iso Hiroyasu, Tamakoshi Akiko

CIRCULATION Vol. 135 2017.3

Yuanying Li, Hiroshi Yatsuya, Yoshihisa Hirakawa, Atsuhiko Ota, Masaaki Matsunaga, Hilawe Esayas Haregot, Chifa Chiang, Yan Zhang, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

CIRCULATION Vol. 135 2017.3

Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke Reviewed

Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Akiko Tamakoshi

CIRCULATION Vol. 135 2017.3

No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study Reviewed International journal

Eri Eguchi, Hiroyasu Iso, Kaori Honjo, Hiroshi Yatsuya, Akiko Tamakoshi

SCIENTIFIC REPORTS Vol. 7 page： 39820 2017.1

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

We examined the effect of education level on the association between healthy lifestyle behaviors and cardiovascular mortality in the Japanese population. A total of 42,647 community-based men and women aged 40-79 years were enrolled at baseline (1988-1990), followed through 2009. The components of the healthy lifestyle score included the intake of fruits, fish, and milk; body mass index; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. During the 19.3 years of follow-up, 8,314 all-cause and 2,377 total cardiovascular mortality cases were noted. Inverse associations were observed between healthy lifestyle scores and total cardiovascular disease (CVD) for both the lower and higher education level groups. Multivariable hazard ratios (95% confidence interval) for CVD mortality from the highest to the lowest healthy lifestyle scores, and the population attributable fraction (95% CIs) without healthy lifestyle scores of 7-8 were 0.51 (0.33-0.52) and 42% (24-58%), and 0.38 (0.27-0.47) and 55% (36-69%) for the higher and lower education levels, respectively. Our findings suggest that the association between higher CVD mortality and lower education level can be explained by the individuals' lower adherence to a healthy lifestyle; hence, lifestyle modification would be beneficial for the prevention of cardiovascular mortality, irrespective of the education level.

DOI： 10.1038/srep39820

Population profile and residential environment of an urban poor community in Dhaka, Bangladesh Reviewed International coauthorship International journal

Md Khalequzzaman, Chifa Chiang, Bilqis Amin Hoque, Sohel Reza Choudhury, Saika Nizam, Hiroshi Yatsuya, Akiko Matsuyama, Yoshihisa Hirakawa, Syed Shariful Islam, Hiroyasu Iso, Atsuko Aoyama

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE Vol. 22 ( 1 ) page： 1 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Objectives: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor.
Methods: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member.
Results: We found that there were 8604 households and 34,170 people in the community. Average number of household members was 4.0. Most people had access to safe water, but only 16% lived in the house with a toilet. Based on the proxy indicators of household wealth levels, we identified that about 39% were relatively well-off, while the rest were very poor. Tobacco use was prevalent in men regardless of age and in women aged over 35 years. Prevalence of self-reported hypertension and diabetes was slightly higher in women than in men, although over 70% of the respondents didn't know if they had such diseases. Incidences of diarrhea in the last one month were relatively low.
Conclusions: The study showed population profile and sanitation environment in an urban poor community by a complete count survey. We expect the study to serve as a baseline for future epidemiological studies.

DOI： 10.1186/s12199-017-0610-2

Risk Factor of Cardiovascular Disease Among Older Individuals Reviewed International journal

Hiroshi Yatsuya, Masaaki Matsunaga, Yuanying Li, Atsuhiko Ota

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS Vol. 24 ( 3 ) page： 258 - 261 2017

Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN) Reviewed

Yoichiro Hirakawa, the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN), Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Takeo Nakayama, Toshimi Sairenchi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya

Journal of Epidemiology Vol. 27 ( 3 ) page： 123 - 129 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiology Association

Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62
95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13
95% CI, 1.47-3.09) and stroke (HR 1.40
95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

DOI： 10.1016/j.je.2016.04.001