Faculty Profiles - YATSUYA Hiroshi

Papers - YATSUYA Hiroshi

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Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. Reviewed

Shirai K, Ohmiya N, Taguchi A, Mabuchi N, Yatsuya H, Itoh A, Hirooka Y, Niwa Y, Mori N, Goto H.

J Gastroenterol Hepatol Vol. 21 ( 7 ) page： 1129-1135 2006

Seasonal variations of acute massive submacular haemorrhage associated with age-related macular degeneration. Reviewed

Iguchi Y, Ito Y, Kikuchi M, Ishikawa K, Oshima H, Yatsuya H, Terasaki H.

Br J Ophthalmol Vol. 90 ( 10 ) page： 1256-1258 2006

Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. Reviewed Open Access

Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

Nagoya J Med Sci Vol. 68 ( 3-4 ) page： 121-130 2006

HIV prevalence and factors associated with HIV infection among male injection drug users under 30: a cross-sectional study in Long An, Vietnam. Reviewed International coauthorship Open Access

Tran TM, Nguyen HT, Yatsuya H, Hamajima N, Nishimura A, Ito K.

BMC Public Health Vol. 10 ( 6 ) page： 248 2006

A positive association between leptin and blood pressure of normal range in Japanese men. Reviewed

Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

Hypertens Res Vol. 29 ( 7 ) page： 485-492 2006

Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. Reviewed

Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

Journal of Epidemiology Vol. 15 ( S2 ) page： S120-S125 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

Mortality and incidence rates of stomach cancer in the JACC Study. Reviewed Open Access

J Epidemiol Vol. 15 ( S2 ) page： S89-S97 2005

Dietary habits and stomach cancer risk in the JACC Study. Reviewed Open Access

Tokui N, Yoshimura T, Fujino Y, Mizoue T, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Kubo T, Tamakoshi A; JACC Study Group.

J Epidemiol Vol. 15 ( S2 ) page： S98-S108 2005

Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci Vol. 96 ( 9 ) page： 590-599 2005

Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res Vol. 31 ( 5 ) page： 452-458 2005

Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. Reviewed Open Access

Kikuchi S, Yagyu K, Obata Y, Yingsong L, Yatsuya H, Hoshiyama Y, Kondo T, Sakata K, Mizoue T, Tokui N, Fujino Y, Tamakoshi A, Toyoshima H, Ishibashi T, Hayakawa N, Yoshimura T; JACC Study Group.

J Epidemiol Vol. 15 ( S2 ) page： S126-S133 2005

出生時体重と成人期の生活習慣病との関連－胎児期起源仮説－ Invited

玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明.

現代医学 Vol. 52 page： 321-325 2005

突然死と性差 Invited

玉腰浩司、豊嶋英明、八谷寛.

日本臨床 Vol. 63 page： 1284-1288 2005

肥満の健康影響 Invited

八谷寛、玉腰浩司、豊嶋英明.

現代医学 Vol. 52 page： 521-526 2005

肥満の科学的解明とエビデンスに基づいた対策・指導 Invited

八谷寛、松下邦洋、玉腰浩司、大塚礼、和田恵子、豊嶋英明.

産業医学レビュー Vol. 18 page： 71-116 2005

職域コホート男性における血清レプチン濃度と生活習慣との関連 Reviewed Open Access

Vol. 63 page： 1284-1288 2005

Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. Reviewed

Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

Asian Pacific Journal of Cancer Prevention Vol. 6 ( 2 ) page： 170-176 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.

Familial aggregation and coaggregation of history of hypertension and stroke. Reviewed

Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

J Hum Hypertens Vol. 19 ( 2 ) page： 119-25 2005

Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Reviewed Open Access

Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

Circ J Vol. 69 ( 1 ) page： 13-8 2005

Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. Reviewed

Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci Vol. 96 ( 1 ) page： 57-62 2005

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Papers - YATSUYA Hiroshi