Faculty Profiles - YATSUYA Hiroshi

Papers - YATSUYA Hiroshi

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The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease Reviewed International journal

Suzuki Daijiro, Suzuki Takanori, Fujino Masayuki, Asai Yumiko, Kojima Arisa, Uchida Hidetoshi, Saito Kazuyoshi, Kusuki Hirofumi, Li Yuanying, Yatsuya Hiroshi, Sadanaga Tsuneaki, Hata Tadayoshi, Yoshikawa Tetsushi

Fujita Medical Journal Vol. 9 ( 4 ) page： 275 - 281 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Fujita Medical Society

Objectives: The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD.Methods: We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan).Results: The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer–Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit.Conclusions: The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.

DOI： 10.20407/fmj.2023-001

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Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers’ cohort study, 2002–2019 Reviewed International coauthorship

KM Saif-Ur-Rahman, Young Jae Hong, Yuanying Li, Masaaki Matsunaga, Zean Song, Masako Shimoda, Abubakr Al-Shoaibi, Yupeng He, Md Razib Mamun, Yukiko Hirano, Chifa Chiang, Yoshihisa Hirakawa, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Rei Otsuka, Hiroshi Yatsuya

Heliyon Vol. 9 ( 11 ) page： e21931 - e21931 2023.11

Good death for people living with dementia: a qualitative study Reviewed

Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

BMC GERIATRICS Vol. 23 ( 1 ) page： 665 2023.10

Authorship：Corresponding author Language：English Publisher：BMC Geriatrics

Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

DOI： 10.1186/s12877-023-04395-y

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Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis. Reviewed International coauthorship International journal

Morgan E Grams, Josef Coresh, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Aditya Surapaneni, Natalia Alencar de Pinho, Amanda Anderson, Lawrence J Appel, Johan Ärnlöv, Fereidoun Azizi, Nisha Bansal, Samira Bell, Henk J G Bilo, Nigel J Brunskill, Juan J Carrero, Steve Chadban, John Chalmers, Jing Chen, Elizabeth Ciemins, Massimo Cirillo, Natalie Ebert, Marie Evans, Alejandro Ferreiro, Edouard L Fu, Masafumi Fukagawa, Jamie A Green, Orlando M Gutierrez, William G Herrington, Shih-Jen Hwang, Lesley A Inker, Kunitoshi Iseki, Tazeen Jafar, Simerjot K Jassal, Vivekanand Jha, Aya Kadota, Ronit Katz, Anna Köttgen, Tsuneo Konta, Florian Kronenberg, Brian J Lee, Jennifer Lees, Adeera Levin, Helen C Looker, Rupert Major, Cheli Melzer Cohen, Makiko Mieno, Mariko Miyazaki, Olivier Moranne, Isao Muraki, David Naimark, Dorothea Nitsch, Wonsuk Oh, Michelle Pena, Tanjala S Purnell, Charumathi Sabanayagam, Michihiro Satoh, Simon Sawhney, Elke Schaeffner, Ben Schöttker, Jenny I Shen, Michael G Shlipak, Smeeta Sinha, Benedicte Stengel, Keiichi Sumida, Marcello Tonelli, Jose M Valdivielso, Arjan D van Zuilen, Frank L J Visseren, Angela Yee-Moon Wang, Chi-Pang Wen, David C Wheeler, Hiroshi Yatsuya, Kunihiro Yamagata, Jae Won Yang, Ann Young, Haitao Zhang, Luxia Zhang, Andrew S Levey, Ron T Gansevoort

JAMA Vol. 330 ( 13 ) page： 1266 - 1277 2023.10

Language：English Publishing type：Research paper (scientific journal)

IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. OBJECTIVE: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. DESIGN, SETTING, AND PARTICIPANTS: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. EXPOSURES: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). MAIN OUTCOMES AND MEASURES: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. RESULTS: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, including those in the mildest categories of chronic kidney disease. For example, among people with a UACR less than 10 mg/g, an eGFR of 45 to 59 mL/min/1.73 m2 based on creatinine alone was associated with significantly higher hospitalization rates compared with an eGFR of 90 to 104 mL/min/1.73 m2 (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.3]; 161 vs 79 events per 1000 person-years; excess absolute risk, 22 events per 1000 person-years [95% CI, 19-25 events per 1000 person-years]). CONCLUSIONS AND RELEVANCE: In this retrospective analysis of 114 cohorts, lower eGFR based on creatinine alone, lower eGFR based on creatinine and cystatin C, and more severe UACR were each associated with increased rates of 10 adverse outcomes, including adverse kidney outcomes, cardiovascular diseases, and hospitalizations.

DOI： 10.1001/jama.2023.17002

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孤食は、世帯構成や孤独感とは独立した抑うつ関連因子である愛知職域コホート研究

洪英在, 大塚礼, 平川仁尚, 太田充彦, 玉腰浩司, 八谷寛

日本公衆衛生学会総会抄録集 Vol. 82回 page： 286 - 286 2023.10

Applicability of a web-based 24-hour dietary recall tool for Japanese populations in large-scale epidemiological studies. Reviewed

Yoshie Hose, Junko Ishihara, Ayaka Kotemori, Misako Nakadate, Sachiko Maruya, Junta Tanaka, Hiroshi Yatsuya, Atsuko Aoyama, Chifa Chiang, Tsuneo Konta, Takamasa Kayama, Yoshiyuki Ueno, Manami Inoue, Norie Sawada, Shoichiro Tsugane, Ribeka Takachi

Journal of epidemiology Vol. 33 ( 8 ) page： 419 - 427 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Recent innovations in information and communication technology have made it possible to assess diet using web-based methods; however, their applicability in the general population remains unclear. Hence, we aimed to examine the applicability of a web-based 24-hour dietary recall (24HR) tool to large-scale epidemiological studies by determining the sampling rate and characteristics of randomly selected participants (partially entire population) from a Japanese cohort study. METHODS: In total, 5,013 individuals were recruited from a cohort of 21,537 individuals, and 975 agreed to participate in this study. The participants selected either self-administered web-based dietary 24HR (self-administered 24HR) or interviewer-administered telephone-based 24HR (interviewer-administered 24HR) as the method for the dietary assessment and answered questions regarding the acceptability of the system. RESULTS: The response rate of the 975 participants was 19.4%, and approximately 4.5% of the total study population. About half of them chose the self-administered 24HR (46.9%). The median time required for the self-administered and interviewer-administered 24HR was 25 and 27 minutes, respectively. In the self-administered 24HR, older people, regardless of sex, tended to require a longer time, and approximately 60% of the participants rated the ease of use of the system as "somewhat difficult" or "difficult." CONCLUSIONS: Characteristics of the participants in this study were not systemically different from those of the entire study population. Improvements in approach for the entering cooking details and the dish name selection may be necessary for better acceptability in order to be accepted as a self-administered 24HR.

DOI： 10.2188/jea.JE20220071

Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease - The Japan Public Health Center-Based Prospective Study. Reviewed

Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

Circulation journal : official journal of the Japanese Circulation Society Vol. 87 ( 9 ) page： 1196 - + 2023.8

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

BACKGROUND: There is considerable interest in the trending discrepancy between ischemic heart disease (IHD) and heart failure (HF) in vital statistics. Clinically, acute myocardial infarction (AMI) and stroke are closely associated with HF, but their contribution to HF as the underlying cause of death (UCD) is unclear.Methods and Results: In 1990 and 1992-1993, we enrolled a total of 140,420 residents of Japanese nationality (aged 40-69 years) from 11 public health center areas. We prospectively examined the occurrence of cardiovascular disease (CVD), including AMI, sudden cardiac death within 1 h (SCD), and stroke, and analyzed the 14,375 participants without a history of CVD at baseline who died during the 20-year follow-up. A time-dependent Cox proportional hazards model was used to estimate hazard ratios and the population attributable fraction (PAF) of AMI, AMI+SCD, stroke, and CVD for deaths due to HF, IHD, and cerebrovascular disease as the UCD, adjusted for individuals' lifestyles and comorbid conditions. The PAF of AMI for HF deaths was 2.4% (95% confidence interval [CI] 1.7-2.9%), which increased to 12.0% (95% CI 11.6-12.2%) for AMI+SCD. The PAF of CVD-attributed HF deaths was estimated to be 17.6% (95% CI 15.9-18.9%). CONCLUSIONS: HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.

DOI： 10.1253/circj.CJ-22-0805

Associations between changes in social contact pattern and the mental health status of Chinese adults: cross-sectional findings Reviewed International coauthorship

Zhang, JY; Zhou, S; Wang, Q; Hou, FF; Han, X; Shen, GD; Chiang, CF; Yatsuya, H; Zhang, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 3 ) page： 476 - 489 2023.8

Language：English Publisher：Nagoya Journal of Medical Science

The study aims to examine the associations between social contact pattern changes and mental health status, including depression, anxiety, and loneliness, among Chinese adults in the context of coronavirus disease 2019 (COVID-19). Data on social contact patterns before and after the outbreak of COVID-19 were obtained from 3511 participants. Mental health (ie, depression, anxiety, and loneliness) was assessed by the 9-item Patient Health Questionnaire, Dark Future Scale, and the 9-scale Three-Item Loneliness Scale, respectively. Poisson regression analyses revealed that the participants who had increased in-person communication were more likely to have mental disorders [depression: prevalence ratio (PR)=1.13, 95% confidence interval (CI): 1.02, 1.26; anxiety: PR=1.15, 95% CI: 1.01, 1.30]. The current study concluded that the in-person communication increase before and after the outbreak of COVID-19 was associated with mental disorders among Chinese adults.

DOI： 10.18999/nagjms.85.3.476

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Risk and population attributable fraction of stroke subtypes in Japan. Reviewed

Hiroshi Yatsuya, Kazumasa Yamagishi, Yuanying Li, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Manami Inoue, Shoichiro Tsugane, Hiroyasu Iso, Norie Sawada

Journal of epidemiology Vol. 34 ( 5 ) page： 211 - 217 2023.7

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Associations of major risk factors for stroke with total and each type of stroke as well as subtypes of ischemic stroke and their population attributable fractions had not been examined comprehensively. METHODS: Participants of the Japan Public Health Center-based prospective (JPHC) Study Cohort II without histories of cardiovascular disease and cancer (n=14,797) were followed from 1993 through 2012. Associations of current smoking, hypertension, diabetes, overweight (body mass index ≥ 25 kg/m2), non-high-density lipoprotein cholesterol (non-HDLC) categories, low HDLC (< 40 mg/dL), urine protein, and history of arrhythmia were examined in a mutually-adjusted Cox regression model that included age and sex. Population attributable fraction (PAF) was estimated using the hazard ratios and the prevalence of risk factors among cases. RESULTS: Subjects with hypertension were 1.63 to 1.84 times more likely to develop any type of stroke. Diabetes, low HDLC, current smoking, overweight, urine protein, and arrhythmia were associated with risk of overall and ischemic stroke. Hypertension and urine protein were associated with risk of intracerebral hemorrhage while current smoking, hypertension, and low non-HDLC were associated with subarachnoid hemorrhage. Hypertension alone accounted for more than a quarter of stroke incidence, followed by current smoking and diabetes. High non-HDLC, current smoking, low HDLC, and overweight contributed mostly to large-artery occlusive stroke. Arrhythmia explained 13.2% of embolic stroke. Combined PAFs of all the modifiable risk factors for total, ischemic and large-artery occlusive strokes were 36.7 and 44.5% and 61.5%, respectively. CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.

DOI： 10.2188/jea.JE20220364

Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers. Reviewed International coauthorship

Ehab S Eshak, Sachiko Baba, Hiroshi Yatsuya, Hiroyasu Iso, Yoshihisa Hirakawa, Eman M Mahfouz, Chiang Chifa, Ryoto Sakaniwa, Ayman S El-Khateeb

Journal of epidemiology Vol. 33 ( 7 ) page： 360 - 366 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: Work-family conflicts (total-WFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association. METHODS: In a cross-cultural study of 4792 Japanese Aichi Workers' Cohort study participants and 3109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured total-WFCs and Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. Logistic regression models estimated odds ratios (ORs) of having depression and a high-ikigai across levels of total-WFCs (low, moderate, and high), and the PROCESS macro of Hayes tested the mediation effect. RESULTS: The prevalence of high total-WFCs, depression, and having a high-ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men. Compared with participants with low total-WFCs, the multivariable ORs (95% CIs) of depression in Japanese women and men with high total-WFCs were 4.11 (2.99-5.65) and 5.42 (4.18-7.02), and those in Egyptian women and men were 4.43 (3.30-5.95) and 4.79 (3.53-6.48). The respective ORs of having a high-ikigai were 0.46 (0.33-0.64) and 0.40 (0.31-0.52) in Japanese women and men and were 0.34 (0.24-0.48) and 0.28 (0.20-0.39) in Egyptian women and men. No interaction between total-WFCs and country was observed for the associations with depression or ikigai. Ikigai has mediated (up to 18%) the associations between the total-WFCs and depression, especially in Egyptian civil workers. CONCLUSIONS: Total-WFCs were associated with depression, and having low-ikigai mediated these associations in Japanese and Egyptian civil workers.

DOI： 10.2188/jea.JE20210338

Impact of combined resection of the internal iliac artery on loss of volume of the gluteus muscles after pelvic exenteration Reviewed

Murata, Y; Uehara, K; Ogura, A; Ishigaki, S; Aiba, T; Mizuno, T; Kokuryo, T; Yokoyama, Y; Yatsuya, H; Ebata, T

SURGERY TODAY Vol. 53 ( 7 ) page： 791 - 799 2023.7

Language：English Publisher：Surgery Today

Purpose: To clarify the influence of additional internal iliac artery (IIA) resection on the loss of the gluteus muscle volume after pelvic exenteration (PE). Methods: The subjects of this retrospective analysis were 78 patients who underwent PE with or without IIA resection (n = 44 and n = 34, respectively) between 2006 and 2018. The areas of gluteal muscles (GMs) and psoas muscles (PSMs) were calculated using CT images before and 6 months after PE, and the difference was compared. Results: The volumes of the GMs and PSMs were significantly reduced after PE (P < 0.001 and P = 0.005, respectively). In the IIA resection group, the GMs were significantly reduced after surgery, but the PSMs were not. The maximum GM (Gmax) was the most atrophied among the GMs. Multivariable analysis revealed that complete IIA resection was an independent promotor of the loss of volume of the Gmax (P = 0.044). In 18 patients with unilateral IIA resection, the downsizing rate of the Gmax was significantly greater on the resected side than on the non-resected side (P = 0.008). Conclusions: The GMs and PSMs were significantly smaller after PE. Complete IIA resection reduced the Gmax area remarkably. Preservation of the superior gluteus artery is likely to help maintain Gmax size, suggesting a potential preventative measure against secondary sarcopenia.

DOI： 10.1007/s00595-022-02635-z

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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Reviewed International coauthorship

Kanyin Liane Ong, Lauryn K Stafford, Susan A McLaughlin, Edward J Boyko, Stein Emil Vollset, Amanda E Smith, Bronte E Dalton, Joe Duprey, Jessica A Cruz, Hailey Hagins, Paulina A Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mohammadreza Abbasian, Zeinab Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Samar Abd ElHafeez, Rami Abd-Rabu, Deldar Morad Abdulah, Abu Yousuf Md Abdullah, Vida Abedi, Hassan Abidi, Richard Gyan Aboagye, Hassan Abolhassani, Eman Abu-Gharbieh, Ahmed Abu-Zaid, Tigist Demssew Adane, Denberu Eshetie Adane, Isaac Yeboah Addo, Oyelola A Adegboye, Victor Adekanmbi, Abiola Victor Adepoju, Qorinah Estiningtyas Sakilah Adnani, Rotimi Felix Afolabi, Gina Agarwal, Zahra Babaei Aghdam, Marcela Agudelo-Botero, Constanza Elizabeth Aguilera Arriagada, Williams Agyemang-Duah, Bright Opoku Ahinkorah, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmad, Ali Ahmadi, Keivan Ahmadi, Ayman Ahmed, Ali Ahmed, Luai A Ahmed, Syed Anees Ahmed, Marjan Ajami, Rufus Olusola Akinyemi, Hanadi Al Hamad, Syed Mahfuz Al Hasan, Tareq Mohammed Ali AL-Ahdal, Tariq A Alalwan, Ziyad Al-Aly, Mohammad T AlBataineh, Jacqueline Elizabeth Alcalde-Rabanal, Sharifullah Alemi, Hassam Ali, Tahereh Alinia, Syed Mohamed Aljunid, Sami Almustanyir, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Firehiwot Amare, Edward Kwabena Ameyaw, Sohrab Amiri, Ganiyu Adeniyi Amusa, Catalina Liliana Andrei, Ranjit Mohan Anjana, Adnan Ansar, Golnoosh Ansari, Alireza Ansari-Moghaddam, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y Aravkin, Demelash Areda, Hidayat Arifin, Mesay Arkew, Benedetta Armocida, Johan Ärnlöv, Anton A Artamonov, Judie Arulappan, Raphael Taiwo Aruleba, Ashokan Arumugam, Zahra Aryan, Mulu Tiruneh Asemu, Mohammad Asghari-Jafarabadi, Elaheh Askari, Daniel Asmelash, Thomas Astell-Burt, Mohammad Athar, Seyyed Shamsadin Athari, Maha Moh'd Wahbi Atout, Leticia Avila-Burgos, Ahmed Awaisu, Sina Azadnajafabad, Darshan B B, Hassan Babamohamadi, Muhammad Badar, Alaa Badawi, Ashish D Badiye, Nayereh Baghcheghi, Nasser Bagheri, Sara Bagherieh, Sulaiman Bah, Saeed Bahadory, Ruhai Bai, Atif Amin Baig, Ovidiu Constantin Baltatu, Hamid Reza Baradaran, Martina Barchitta, Mainak Bardhan, Noel C Barengo, Till Winfried Bärnighausen, Mark Thomaz Ugliara Barone, Francesco Barone-Adesi, Amadou Barrow, Hamideh Bashiri, Afisu Basiru, Sanjay Basu, Saurav Basu, Abdul-Monim Mohammad Batiha, Kavita Batra, Mulat Tirfie Bayih, Nebiyou Simegnew Bayileyegn, Amir Hossein Behnoush, Alehegn Bekele Bekele, Melaku Ashagrie Belete, Uzma Iqbal Belgaumi, Luis Belo, Derrick A Bennett, Isabela M Bensenor, Kidanemaryam Berhe, Alemshet Yirga Berhie, Sonu Bhaskar, Ajay Nagesh Bhat, Jasvinder Singh Bhatti, Boris Bikbov, Faiq Bilal, Bagas Suryo Bintoro, Saeid Bitaraf, Veera R Bitra, Vesna Bjegovic-Mikanovic, Virginia Bodolica, Archith Boloor, Michael Brauer, Javier Brazo-Sayavera, Hermann Brenner, Zahid A Butt, Daniela Calina, Luciana Aparecida Campos, Ismael R Campos-Nonato, Yin Cao, Chao Cao, Josip Car, Márcia Carvalho, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Ester Cerin, Joshua Chadwick, Eeshwar K Chandrasekar, Gashaw Sisay Chanie, Jaykaran Charan, Vijay Kumar Chattu, Kirti Chauhan, Huzaifa Ahmad Cheema, Endeshaw Chekol Abebe, Simiao Chen, Nicolas Cherbuin, Fatemeh Chichagi, Saravana Babu Chidambaram, William C S Cho, Sonali Gajanan Choudhari, Rajiv Chowdhury, Enayet Karim Chowdhury, Dinh-Toi Chu, Isaac Sunday Chukwu, Sheng-Chia Chung, Kaleb Coberly, Alyssa Columbus, Daniela Contreras, Ewerton Cousin, Michael H Criqui, Natália Cruz-Martins, Sarah Cuschieri, Bashir Dabo, Omid Dadras, Xiaochen Dai, Albertino Antonio Moura Damasceno, Rakhi Dandona, Lalit Dandona, Saswati Das, Ana Maria Dascalu, Nihar Ranjan Dash, Mohsen Dashti, Claudio Alberto Dávila-Cervantes, Vanessa De la Cruz-Góngora, Gebiso Roba Debele, Kourosh Delpasand, Fitsum Wolde Demisse, Getu Debalkie Demissie, Xinlei Deng, Edgar Denova-Gutiérrez, Salil V Deo, Emina Dervišević, Hardik Dineshbhai Desai, Aragaw Tesfaw Desale, Anteneh Mengist Dessie, Fikreab Desta, Syed Masudur Rahman Dewan, Sourav Dey, Kuldeep Dhama, Meghnath Dhimal, Nancy Diao, Daniel Diaz, Monica Dinu, Mengistie Diress, Shirin Djalalinia, Linh Phuong Doan, Deepa Dongarwar, Francisco Winter dos Santos Figueiredo, Bruce B Duncan, Siddhartha Dutta, Arkadiusz Marian Dziedzic, Hisham Atan Edinur, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Islam Y Elgendy, Muhammed Elhadi, Waseem El-Huneidi, Omar Abdelsadek Abdou Elmeligy, Mohamed A Elmonem, Destaw Endeshaw, Hawi Leul Esayas, Habitu Birhan Eshetu, Farshid Etaee, Ibtihal Fadhil, Adeniyi Francis Fagbamigbe, Ayesha Fahim, Shahab Falahi, MoezAlIslam Ezzat Mahmoud Faris, Hossein Farrokhpour, Farshad Farzadfar, Ali Fatehizadeh, Ghazal Fazli, Xiaoqi Feng, Tomas Y Ferede, Florian Fischer, David Flood, Ali Forouhari, Roham Foroumadi, Masoumeh Foroutan Koudehi, Abhay Motiramji Gaidhane, Santosh Gaihre, Abduzhappar Gaipov, Yaseen Galali, Balasankar Ganesan, MA Garcia-Gordillo, Rupesh K Gautam, Mesfin Gebrehiwot, Kahsu Gebrekirstos Gebrekidan, Teferi Gebru Gebremeskel, Lemma Getacher, Fataneh Ghadirian, Seyyed-Hadi Ghamari, Mohammad Ghasemi Nour, Fariba Ghassemi, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Sameer Vali Gopalani, Habtamu Alganeh Guadie, Shi-Yang Guan, Temesgen Worku Gudayu, Rafael Alves Guimarães, Rashid Abdi Guled, Rajeev Gupta, Kartik Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Bishal Gyawali, Rasool Haddadi, Najah R Hadi, Teklehaimanot Gereziher Haile, Ramtin Hajibeygi, Arvin Haj-Mirzaian, Rabih Halwani, Samer Hamidi, Graeme J Hankey, Md Abdul Hannan, Shafiul Haque, Hamid Harandi, Netanja I Harlianto, S M Mahmudul Hasan, Syed Shahzad Hasan, Hamidreza Hasani, Soheil Hassanipour, Mohammed Bheser Hassen, Johannes Haubold, Khezar Hayat, Golnaz Heidari, Mohammad Heidari, Kamran Hessami, Yuta Hiraike, Ramesh Holla, Sahadat Hossain, Md Shakhaoat Hossain, Mohammad-Salar Hosseini, Mehdi Hosseinzadeh, Hassan Hosseinzadeh, Junjie Huang, Md Nazmul Huda, Salman Hussain, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Nayu Ikeda, Irena M Ilic, Milena D Ilic, Leeberk Raja Inbaraj, Afrin Iqbal, Sheikh Mohammed Shariful Islam, Rakibul M Islam, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Ramaiah Itumalla, Masao Iwagami, Chidozie C D Iwu, Ihoghosa Osamuyi Iyamu, Assefa N Iyasu, Louis Jacob, Abdollah Jafarzadeh, Haitham Jahrami, Rajesh Jain, Chinwe Jaja, Zahra Jamalpoor, Elham Jamshidi, Balamurugan Janakiraman, Krishnamurthy Jayanna, Sathish Kumar Jayapal, Shubha Jayaram, Ranil Jayawardena, Rime Jebai, Wonjeong Jeong, Yinzi Jin, Mohammad Jokar, Jost B Jonas, Nitin Joseph, Abel Joseph, Charity Ehimwenma Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Billingsley Kaambwa, Ali Kabir, Robel Hussen Kabthymer, Vidya Kadashetti, Farima Kahe, Rohollah Kalhor, Himal Kandel, Shama D Karanth, Ibraheem M Karaye, Samad Karkhah, Patrick DMC Katoto, Navjot Kaur, Sina Kazemian, Sewnet Adem Kebede, Yousef Saleh Khader, Himanshu Khajuria, Amirmohammad Khalaji, Moien AB Khan, Maseer Khan, Ajmal Khan, Saval Khanal, Moawiah Mohammad Khatatbeh, Amir M Khater, Sorour Khateri, Fatemeh khorashadizadeh, Jagdish Khubchandani, Biruk Getahun Kibret, Min Seo Kim, Ruth W Kimokoti, Adnan Kisa, Mika Kivimäki, Ali-Asghar Kolahi, Somayeh Komaki, Farzad Kompani, Hamid Reza Koohestani, Oleksii Korzh, Karel Kostev, Nikhil Kothari, Ai Koyanagi, Kewal Krishan, Yuvaraj Krishnamoorthy, Barthelemy Kuate Defo, Mohammed Kuddus, Md Abdul Kuddus, Rakesh Kumar, Harish Kumar, Satyajit Kundu, Maria Dyah Kurniasari, Ambily Kuttikkattu, Carlo La Vecchia, Tea Lallukka, Bagher Larijani, Anders O Larsson, Kamaluddin Latief, Basira Kankia Lawal, Thao Thi Thu Le, Trang Thi Bich Le, Shaun Wen Huey Lee, Munjae Lee, Wei-Chen Lee, Paul H Lee, Sang-woong Lee, Seung Won Lee, Samson Mideksa Legesse, Jacopo Lenzi, Yongze Li, Ming-Chieh Li, Stephen S Lim, Lee-Ling Lim, Xuefeng Liu, Chaojie Liu, Chun-Han Lo, Graciliana Lopes, Stefan Lorkowski, Rafael Lozano, Giancarlo Lucchetti, Azzam A Maghazachi, Phetole Walter Mahasha, Soleiman Mahjoub, Mansour Adam Mahmoud, Razzagh Mahmoudi, Marzieh Mahmoudimanesh, Anh Tuan Mai, Azeem Majeed, Pantea Majma Sanaye, Konstantinos Christos Makris, Kashish Malhotra, Ahmad Azam Malik, Iram Malik, Tauqeer Hussain Mallhi, Deborah Carvalho Malta, Abdullah A Mamun, Borhan Mansouri, Hamid Reza Marateb, Parham Mardi, Santi Martini, Miquel Martorell, Roy Rillera Marzo, Reza Masoudi, Sahar Masoudi, Elezebeth Mathews, Andrea Maugeri, Giampiero Mazzaglia, Teferi Mekonnen, Mahboobeh Meshkat, Tomislav Mestrovic, Junmei Miao Jonasson, Tomasz Miazgowski, Irmina Maria Michalek, Le Huu Nhat Minh, GK Mini, J Jaime Miranda, Reza Mirfakhraie, Erkin M Mirrakhimov, Mohammad Mirza-Aghazadeh-Attari, Awoke Misganaw, Kebede Haile Misgina, Manish Mishra, Babak Moazen, Nouh Saad Mohamed, Esmaeil Mohammadi, Mohsen Mohammadi, Abdollah Mohammadian-Hafshejani, Marita Mohammadshahi, Alireza Mohseni, Hoda Mojiri-forushani, Ali H Mokdad, Sara Momtazmanesh, Lorenzo Monasta, Md Moniruzzaman, Ute Mons, Fateme Montazeri, AmirAli Moodi Ghalibaf, Yousef Moradi, Maryam Moradi, Mostafa Moradi Sarabi, Negar Morovatdar, Shane Douglas Morrison, Jakub Morze, Elias Mossialos, Ebrahim Mostafavi, Ulrich Otto Mueller, Francesk Mulita, Admir Mulita, Efrén Murillo-Zamora, Kamarul Imran Musa, Julius C Mwita, Shankar Prasad Nagaraju, Mohsen Naghavi, Firzan Nainu, Tapas Sadasivan Nair, Hastyar Hama Rashid Najmuldeen, Vinay Nangia, Shumaila Nargus, Abdallah Y Naser, Hasan Nassereldine, Zuhair S Natto, Javaid Nauman, Biswa Prakash Nayak, Rawlance Ndejjo, Hadush Negash, Ruxandra Irina Negoi, Hau Thi Hien Nguyen, Dang H Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Hien Quang Nguyen, Robina Khan Niazi, Yeshambel T Nigatu, Dina Nur Anggraini Ningrum, Muhammad A Nizam, Lawrence Achilles Nnyanzi, Mamoona Noreen, Jean Jacques Noubiap, Ogochukwu Janet Nzoputam, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Nkechi Martina Odogwu, Oluwakemi Ololade Odukoya, Vivek Anand Ojha, Hassan Okati-Aliabad, Akinkunmi Paul Okekunle, Osaretin Christabel Okonji, Patrick Godwin Okwute, Isaac Iyinoluwa Olufadewa, Obinna E Onwujekwe, Michal Ordak, Alberto Ortiz, Uchechukwu Levi Osuagwu, Abderrahim Oulhaj, Mayowa O Owolabi, Alicia Padron-Monedero, Jagadish Rao Padubidri, Raffaele Palladino, Demosthenes Panagiotakos, Songhomitra Panda-Jonas, Ashok Pandey, Anamika Pandey, Seithikurippu R Pandi-Perumal, Anca Mihaela Pantea Stoian, Shahina Pardhan, Tarang Parekh, Utsav Parekh, Maja Pasovic, Jay Patel, Jenil R Patel, Uttam Paudel, Veincent Christian Filipino Pepito, Marcos Pereira, Norberto Perico, Simone Perna, Ionela-Roxana Petcu, Fanny Emily Petermann-Rocha, Vivek Podder, Maarten J Postma, Ghazaleh Pourali, Naeimeh Pourtaheri, Elton Junio Sady Prates, Mirza Muhammad Fahd Qadir, Ibrahim Qattea, Pourya Raee, Ibrar Rafique, Mehran Rahimi, Mahban Rahimifard, Vafa Rahimi-Movaghar, Md Obaidur Rahman, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Md Mosfequr Rahman, Mohamed Rahmani, Shayan Rahmani, Vahid Rahmanian, Setyaningrum Rahmawaty, Niloufar Rahnavard, Bibek Rajbhandari, Pradhum Ram, Sheena Ramazanu, Juwel Rana, Nemanja Rancic, Muhammad Modassar Ali Nawaz Ranjha, Chythra R Rao, Deepthi Rapaka, Drona Prakash Rasali, Sina Rashedi, Vahid Rashedi, Ahmed Mustafa Rashid, Mohammad-Mahdi Rashidi, Zubair Ahmed Ratan, Salman Rawaf, Lal Rawal, Elrashdy Moustafa Mohamed Redwan, Giuseppe Remuzzi, Kannan RR Rengasamy, Andre M N Renzaho, Luis Felipe Reyes, Nima Rezaei, Nazila Rezaei, Mohsen Rezaeian, Hossein Rezazadeh, Seyed Mohammad Riahi, Yohanes Andy Rias, Muhammad Riaz, Daniela Ribeiro, Mónica Rodrigues, Jefferson Antonio Buendia Rodriguez, Leonardo Roever, Peter Rohloff, Gholamreza Roshandel, Abazar Roustazadeh, Godfrey M Rwegerera, Aly M A Saad, Maha Mohamed Saber-Ayad, Siamak Sabour, Leila Sabzmakan, Basema Saddik, Erfan Sadeghi, Umar Saeed, Sahar Saeedi Moghaddam, Sare Safi, Sher Zaman Safi, Amene Saghazadeh, Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Amirhossein Sahebkar, Soumya Swaroop Sahoo, Harihar Sahoo, KM Saif-Ur-Rahman, Mirza Rizwan Sajid, Sarvenaz Salahi, Saina Salahi, Mohamed A Saleh, Mohammad Amin Salehi, Joshua A Salomon, Juan Sanabria, Rama Krishna Sanjeev, Francesco Sanmarchi, Milena M Santric-Milicevic, Made Ary Sarasmita, Saman Sargazi, Brijesh Sathian, Thirunavukkarasu Sathish, Monika Sawhney, Markus P Schlaich, Maria Inês Schmidt, Art Schuermans, Abdul-Aziz Seidu, Nachimuthu Senthil Kumar, Sadaf G Sepanlou, Yashendra Sethi, Allen Seylani, Maryam Shabany, Tahereh Shafaghat, Melika Shafeghat, Mahan Shafie, Nilay S Shah, Samiah Shahid, Masood Ali Shaikh, Mohd Shanawaz, Mohammed Shannawaz, Sadaf Sharfaei, Bereket Beyene Shashamo, Rahman Shiri, Aminu Shittu, K M Shivakumar, Siddharudha Shivalli, Parnian Shobeiri, Fereshteh Shokri, Kerem Shuval, Migbar Mekonnen Sibhat, Luís Manuel Lopes Rodrigues Silva, Colin R Simpson, Jasvinder A Singh, Paramdeep Singh, Surjit Singh, Md Shahjahan Siraj, Anna Aleksandrovna Skryabina, Abdullah Al Mamun Sohag, Hamidreza Soleimani, Solikhah Solikhah, Mohammad Sadegh Soltani-Zangbar, Ranjani Somayaji, Reed J D Sorensen, Antonina V Starodubova, Sujata Sujata, Muhammad Suleman, Jing Sun, Johan Sundström, Rafael Tabarés-Seisdedos, Seyyed Mohammad Tabatabaei, Seyed-Amir Tabatabaeizadeh, Mohammad Tabish, Majid Taheri, Ensiyeh Taheri, Elahe Taki, Jacques JL Lukenze Tamuzi, Ker-Kan Tan, Nathan Y Tat, Birhan Tsegaw Taye, Worku Animaw Temesgen, Mohamad-Hani Temsah, Riki Tesler, Pugazhenthan Thangaraju, Kavumpurathu Raman Thankappan, Rajshree Thapa, Samar Tharwat, Nihal Thomas, Jansje Henny Vera Ticoalu, Amir Tiyuri, Marcello Tonelli, Marcos Roberto Tovani-Palone, Domenico Trico, Indang Trihandini, Jaya Prasad Tripathy, Samuel Joseph Tromans, Guesh Mebrahtom Tsegay, Abdul Rohim Tualeka, Derara Girma Tufa, Stefanos Tyrovolas, Sana Ullah, Era Upadhyay, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Kim Robin van Daalen, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Siavash Vaziri, Madhur verma Verma, Georgios-Ioannis Verras, Danh Cao Vo, Birhanu Wagaye, Yasir Waheed, Ziyue Wang, Yanqing Wang, Cong Wang, Fang Wang, Gizachew Tadesse Wassie, Melissa Y Wei Wei, Abrha Hailay Weldemariam, Ronny Westerman, Nuwan Darshana Wickramasinghe, YiFan Wu, Ratna DWI Wulandari, Juan Xia, Hong Xiao, Suowen Xu, Xiaoyue Xu, Dereje Y Yada, Lin Yang, Hiroshi Yatsuya, Metin Yesiltepe, Siyan Yi, Hunachew Kibret Yohannis, Naohiro Yonemoto, Yuyi You, Sojib Bin Zaman, Nelson Zamora, Iman Zare, Kourosh Zarea, Armin Zarrintan, Mikhail Sergeevich Zastrozhin, Naod Gebrekrstos Zeru, Zhi-Jiang Zhang, Chenwen Zhong, Jingjing Zhou, Magdalena Zielińska, Yossef Teshome Zikarg, Sanjay Zodpey, Mohammad Zoladl, Zhiyong Zou, Alimuddin Zumla, Yves Miel H Zuniga, Dianna J Magliano, Christopher J L Murray, Simon I Hay, Theo Vos

The Lancet Vol. 402 ( 10397 ) page： 203 - 234 2023.6

Predictive Value of Long-Term Systolic Blood Pressure Variability for the Development of Type 2 Diabetes Mellitus Reviewed

Yatsuya, H; Song, ZA; Hong, YJ; Mamun, R; Yoshida, Y; Akter, T; Nuamah, G; Tajima, R; Lin, JY; Al-Shoaibi, A; Chiang, C; Nakano, Y; Li, YY; Matsunaga, M; Ota, A; Tamakoshi, K

CIRCULATION Vol. 147 2023.2

Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers’ Cohort Study Reviewed

Masako Shimoda, Kayo Kaneko, Takeshi Nakagawa, Naoko Kawano, Rei Otsuka, Atsuhiko Ota, Hisao Naito, Masaaki Matsunaga, Naohiro Ichino, Hiroya Yamada, Chifa Chiang, Yoshihisa Hirakawa, Koji Tamakoshi, Atsuko Aoyama, Hiroshi Yatsuya

Journal of Epidemiology Vol. 33 ( 2 ) page： 76 - 81 2023.2

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

Background: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan.Methods: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate.Results: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29.Conclusion: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.

DOI： 10.2188/jea.JE20210128

Corrigendum to "Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women" [Preventive Medicine 162 (2022) 107145]. Reviewed International journal

Yuka Kobayashi, Kazumasa Yamagishi, Isao Muraki, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

Preventive medicine Vol. 167 page： 107396 - 107396 2023.2

The Association between Adult Height and Stroke Incidence in Japanese Men and Women: A Population- Based Case- Control Study Reviewed

Yoshinobu Kondo, Hiroshi Yatsuya, Atsuhiko Ota, Shoji Matsumoto, Akihiro Ueda, Hirohisa Watanabe, Hideaki Toyoshima

Journal of Epidemiology Vol. 33 ( 1 ) page： 23 - 30 2023.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: No studies have examined the associations between adult height and ischemic stroke subtypes. METHODS: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40-79 years, and the same number of sex- and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height was also examined as a continuous variable as divided by one standard deviation of height in controls. The analyses were carried out separately for participants aged 40-59 years and 60-79 years. RESULTS: In both younger and older men, continuous height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women. CONCLUSIONS: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age-group.

DOI： 10.2188/jea.JE20200531

Including Measures of Chronic Kidney Disease to Improve Cardiovascular Risk Prediction by SCORE2 and SCORE2-OP. Reviewed International coauthorship International journal

Kunihiro Matsushita, Stephen Kaptoge, Steven Hj Hageman, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H Jafar, Simerjot K Jassal, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P Schneider, Varda Shalev, Michael G Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick An Dorresteijn, Emanuele Di Angelantonio, Frank Lj Visseren, Lisa Pennells, Josef Coresh

European journal of preventive cardiology Vol. 30 ( 1 ) page： 8 - 16 2023.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: The 2021 ESC guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, SCORE2 and SCORE2-OP, to predict CVD risk. We developed and validated an "Add-on" to incorporate CKD measures into these algorithms, using a validated approach. METHODS: In 3,054,840 participants from 34 datasets, we developed three Add-ons (eGFR only, eGFR + urinary albumin-to-creatinine ratio [ACR] [the primary Add-on], and eGFR + dipstick proteinuria) for SCORE2 and SCORE2-OP. We validated c-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997,719 participants from 34 different datasets. RESULTS: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved c-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57,485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI (e.g., 0.100 [0.062-0.138] for SCORE2) compared to the qualitative approach in the ESC guideline. CONCLUSION: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

DOI： 10.1093/eurjpc/zwac176

MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

JOURNAL OF HYPERTENSION Vol. 41 page： E134 - E134 2023.1

Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting. Reviewed International coauthorship

Abubakr Ahmed Abdullah Al-Shoaibi, Yuanying Li, Zean Song, Chifa Chiang, Yoshihisa Hirakawa, K M Saif-Ur-Rahman, Masako Shimoda, Yoshihisa Nakano, Masaaki Matsunaga, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Hiroshi Yatsuya

Journal of atherosclerosis and thrombosis Vol. 30 ( 5 ) page： 455 - 466 2023

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

AIMS: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. METHODS: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. RESULTS: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). CONCLUSION: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

DOI： 10.5551/jat.63519

Sociodemographic and behavioral factors related to obesity among adults in the Republic of Palau based on the WHO STEPwise approach to NCD risk factor surveillance 2011-2013: A cross-sectional study. Reviewed International coauthorship

Miyuki Hasegawa, Kaori Honjo, Chifa Chiang, Takashi Mita, Berry Moon Watson, Edolem Ikerdeu, Sherilynn Madraisau, Hiroshi Yatsuya, Atsuko Aoyama, Hiroyasu Iso

Environmental health and preventive medicine Vol. 28 ( 0 ) page： 39 - 39 2023

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Hygiene

BACKGROUND: Pacific islanders face drastic increase of obesity-related noncommunicable disease (NCD) due to lifestyle shifts of unhealthy diets and physical inactivity. To date, however, obesity related factors have not been well elucidated in Republic of Palau. This study aimed to investigate sociodemographic and behavioral factors related to obesity using the national level data in Palau. METHODS: This is a cross-sectional, population-based study analyzing random sampling data of 2133 adults aged 25-64 years (of 20 thousand national population) from the WHO STEPwise approach to NCD risk factor surveillance (STEPS) implemented between 2011 and 2013. Sociodemographic and behavioral factors were obtained by the STEPS standardized questionnaire for NCD risk factors plus the question on betel nut chewing because of its common behavior in Micronesian countries. Logistic regression analysis was performed to estimate multivariable odds ratio (OR) of general obesity (body mass index ≥30.0 kg/m2) and central obesity (waist circumference ≥90 cm in men and ≥80 cm in women). RESULTS: Means of body mass index, prevalence of general obesity and central obesity were higher in women (29.9 kg/m2, 45.5% and 85.4%) than in men (29.3 kg/m2, 40.4% and 67.6%). After adjusted by other potential factors, native Palauan (OR 4.4, 95% CI, 2.7-7.0 for men and 3.6, 2.3-5.6 for women), betel nut chewing (1.5, 1.1-2.1 for men and 1.6, 1.2-2.3 for women), men who work at government office (1.6, 1.2-2.1), women with higher household income (1.4, 1.0-1.8) were positively associated with general obesity, while frequent vegetable intake were inversely associated with it among women (0.71, 0.54-0.93). Similar associations were observed between the aforementioned factors and central obesity. CONCLUSIONS: Native Palauan, people with betel nut chewing behavior, government employment and higher income appeared to be associated with obesity, while frequent vegetable consumption were inversely associated with obesity. Further interventions for prevention and control of obesity are necessary through the enhancing public relation activities to understand harmful health effects on betel nuts chewing and recommending domestic production of vegetables.

DOI： 10.1265/ehpm.22-00309

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