Faculty Profiles - YATSUYA Hiroshi

Papers - YATSUYA Hiroshi

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Low Density Lipoprotein Cholesterol Associations With The Risk Of Coronary Heart Disease And Stroke Among Middle-aged Japanese Workers: Analysis Using Inverse Probability Weighting

Al-shoaibi, AA; Li, YY; Chiang, C; Hirakawa, Y; Song, Z; Saif-Ur-Rahman, KM; Masako, S; Masaaki, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

CIRCULATION Vol. 145 2022.3

Smoking cessation, weight gain and risk of cardiovascular disease. Reviewed International journal

Xiaowen Wang, Jia-Yi Dong, Renzhe Cui, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

Heart (British Cardiac Society) Vol. 108 ( 5 ) page： 375 - 381 2022.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain. METHODS: A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5.0 kg, >5.0 kg), long-term quitters and never smokers. Quitting smoking within and longer than 5 years were defined as recent and long-term quitters, respectively. We used Cox proportional hazard models to estimate the HR for incident CVD, coronary heart disease (CHD) and stroke. RESULTS: We identified 4023 CVDs (889 CHDs and 3217 strokes) during a median of 14.8 years of follow-up. Compared with sustained smokers, the multivariable HR (95% CI) for CVD was 0.66 (0.52 to 0.83) for recent quitters without weight gain, 0.71 (0.55 to 0.90) for recent quitters with weight gain of 0.1-5.0 kg, 0.70 (0.44 to 1.10) for recent quitters with weight gain of >5.0 kg, 0.56 (0.49 to 0.64) for long-term quitters, and 0.60 (0.55 to 0.66) for never smokers. The analysis restricted to men showed a similar association. Prespecified analysis by age suggested that recent quitters overall had a lower HR for CVD among those aged <60 years vs ≥60 years. Similar patterns of association were observed in CHD and stroke. CONCLUSIONS: Postcessation weight gain did not attenuate the protective association between smoking cessation and risk of CVD.

DOI： 10.1136/heartjnl-2021-318972

職業性ストレスと退職後の認知機能低下に関する縦断的研究愛知職域コホート研究

中島啓裕, 江啓発, 平川仁尚, He Yupeng, 霜田真子, 玉腰浩司, 八谷寛

産業ストレス研究 Vol. 29 ( 1 ) page： 169 - 169 2022.3

Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 Reviewed International coauthorship Open Access

Cousin, E; Duncan, BB; Stein, C; Ong, KL; Vos, T; Abbafati, C; Abbasi-Kangevari, M; Abdelmasseh, M; Abdoli, A; Abd-Rabu, R; Abolhassani, H; Abu-Gharbieh, E; Accrombessi, MMK; Adnani, QES; Afzal, MS; Agarwal, G; Agrawaal, KK; Agudelo-Botero, M; Ahinkorah, BO; Ahmad, S; Ahmad, T; Ahmadi, K; Ahmadi, S; Ahmadi, A; Ahmed, A; Salih, YA; Akande-Sholabi, W; Akram, T; Al Hamad, H; Al-Aly, Z; Alcalde-Rabanal, JE; Alipour, V; Aljunid, SM; Al-Raddadi, RM; Alvis-Guzman, N; Amini, S; Ancuceanu, R; Andrei, T; Andrei, CL; Anjana, RM; Ansar, A; Antonazzo, IC; Antony, B; Anyasodor, AE; Arabloo, J; Arizmendi, D; Armocida, B; Artamonov, AA; Arulappan, J; Aryan, Z; Asgari, S; Ashraf, T; Astell-Burt, T; Atorkey, P; Atout, MMW; Ayanore, MA; Badiye, AD; Baig, AA; Bairwa, M; Baker, JL; Baltatu, OC; Banik, PC; Barnett, A; Barone, MTU; Barone-Adesi, F; Barrow, A; Bedi, N; Belete, R; Belgaumi, UI; Bell, AW; Bennett, DA; Bensenor, IM; Beran, D; Bhagavathula, AS; Bhaskar, S; Bhattacharyya, K; Bhojaraja, VS; Bijani, A; Bikbov, B; Birara, S; Bodolica, V; Bonny, A; Brenner, H; Briko, NI; Butt, ZA; dos Santos, FLC; Camera, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Cerin, E; Chakraborty, PA; Chandan, JS; Chattu, VK; Chen, SM; Choi, JYJ; Choudhari, SG; Chowdhury, EK; Chu, DT; Corso, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, L; Dandona, R; Dávila-Cervantes, CA; De Neve, JW; Denova-Gutiérrez, E; Dhamnetiya, D; Diaz, D; Ebtehaj, S; Edinur, HA; Eftekharzadeh, S; El Sayed, I; Elgendy, IY; Elhadi, M; Elmonem, MA; Faisaluddin, M; Farooque, U; Feng, XQ; Fernandes, E; Fischer, F; Flood, D; Freitas, M; Gaal, PA; Gad, MM; Gaewkhiew, P; Getacher, L; Ghafourifard, M; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Gill, PS; Ginawi, IA; Glushkova, EV; Golechha, M; Gopalani, SV; Guimaraes, RA; Das Gupta, R; Gupta, R; Gupta, VK; Gupta, VB; Gupta, S; Habtewold, TD; Hafezi-Nejad, N; Halwani, R; Hanif, A; Hankey, GJ; Haque, S; Hasaballah, AI; Hasan, SS; Hashi, A; Hassanipour, S; Hay, SI; Hayat, K; Heidari, M; Hossain, MBH; Hossain, S; Hosseini, M; Hoveidamanesh, S; Huang, JJ; Humayun, A; Hussain, R; Hwang, BF; Ibitoye, SE; Ikuta, KS; Inbaraj, LR; Iqbal, U; Islam, MS; Islam, SMS; Islam, RM; Ismail, NE; Isola, G; Itumalla, R; Iwagami, M; Iyamu, IO; Jahani, MA; Jakovljevic, M; Jayawardena, R; Jha, RP; John, O; Jonas, JB; Joo, T; Kabir, A; Kalhor, R; Kamath, A; Kanchan, T; Kandel, H; Kapoor, N; Kayode, GA; Kebede, SA; Keshavarz, P; Keykhaei, M; Khader, YS; Khajuria, H; Khan, MAB; Khan, MN; Khan, M; Khater, AM; Khoja, TAM; Khubchandani, J; Kim, MS; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kivimäki, M; Korshunov, VA; Korzh, O; Koyanagi, A; Krishan, K; Defo, BK; Kumar, GA; Kumar, N; Kusuma, D; La Vecchia, C; Lacey, B; Larsson, AO; Lasrado, S; Lee, WC; Lee, CB; Lee, PH; Lee, SWH; Li, MC; Lim, SS; Lim, LL; Lucchetti, G; Majeed, A; Malik, AA; Mansouri, B; Mantovani, LG; Martini, S; Mathur, P; McAlinden, C; Mehedi, N; Mekonnen, T; Menezes, RG; Mersha, AG; Jonasson, JM; Miazgowski, T; Michalek, IM; Mirica, A; Mirrakhimov, EM; Mirza, AZ; Mithra, P; Mohammadian-Hafshejani, A; Mohammadpourhodki, R; Mohammed, A; Mokdad, AH; Molokhia, M; Monasta, L; Moni, MA; Moradpour, F; Moradzadeh, R; Mostafavi, E; Mueller, UO; Murray, CJL; Mustafa, A; Nagel, G; Nangia, V; Naqvi, AA; Nayak, BP; Nazari, J; Ndejjo, R; Negoi, RI; Kandel, N; Nguyen, CT; Nguyen, HLT; Noubiap, JJ; Nowak, C; Oancea, B; Odukoya, OO; Oguntade, AS; Ojo, TT; Olagunju, AT; Onwujekwe, OE; Ortiz, A; Owolabi, MO; Palladino, R; Panda-Jonas, S; Pandi-Perumal, SR; Pardhan, S; Parekh, T; Parvizi, M; Pepito, VCF; Perianayagam, A; Petcu, IR; Pilania, M; Podder, V; Polibin, RV; Postma, MJ; Prashant, A; Rabiee, N; Rabiee, M; Rahimi-Movaghar, V; Rahman, MA; Rahman, MM; Rahman, M; Rahmawaty, S; Rajai, N; Ram, P; Rana, J; Ranabhat, K; Ranasinghe, P; Rao, CR; Rao, S; Rawaf, S; Rawaf, DL; Rawal, L; Renzaho, AMN; Rezaei, N; Rezapour, A; Riahi, SM; Ribeiro, D; Rodriguez, JAB; Roever, L; Rohloff, P; Rwegerera, GM; Ryan, PM; Saber-Ayad, MM; Sabour, S; Saddik, B; Moghaddam, SS; Sahebkar, A; Sahoo, H; Saif-Ur-Rahman, K; Salimzadeh, H; Samaei, M; Sanabria, J; Santric-Milicevic, MM; Sathian, B; Sathish, T; Schlaich, MP; Seidu, AA; Sekerija, M; Kumar, NS; Seylani, A; Shaikh, MA; Shamshad, H; Shawon, MSR; Sheikhbahaei, S; Shetty, JK; Shiri, R; Shivakumar, KM; Shuval, K; Singh, JA; Singh, A; Skryabin, VY; Skryabina, AA; Sofi-Mahmudi, A; Soheili, A; Sun, J; Szerencsés, V; Szócska, M; Tabarés-Seisdedos, R; Tadbiri, H; Tadesse, EG; Tariqujjaman, M; Thankappan, KR; Thapar, R; Thomas, N; Timalsina, B; Tobe-Gai, R; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Car, LT; Tusa, BS; Uddin, R; Upadhyay, E; Tahbaz, SV; Valdez, PR; Vasankari, TJ; Verma, M; Villalobos-Daniel, VE; Vladimirov, SK; Vo, B; Vu, GT; Vukovic, R; Waheed, Y; Wamai, RG; Werdecker, A; Wickramasinghe, ND; Winkler, AS; Wubishet, BL; Xu, XY; Xu, SW; Jabbari, SHY; Yatsuya, H; Yaya, S; Yazie, TSY; Yi, SY; Yonemoto, N; Yunusa, I; Zadey, S; Bin Zaman, S; Zamanian, M; Zamora, N; Zastrozhin, MS; Zastrozhina, A; Zhang, ZJ; Zhong, CW; Zmaili, M; Zumla, A; Naghavi, M; Schmidt, MI

LANCET DIABETES & ENDOCRINOLOGY Vol. 10 ( 3 ) page： 177 - 192 2022.3

Language：English Publisher：Lancet Diabetes and Endocrinology

Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r<sup>2</sup>=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.

DOI： 10.1016/S2213-8587(21)00349-1

Everyday wishes of older people living with dementia in care planning: a qualitative study Reviewed Open Access

Md Razib Mamun, Yoshihisa Hirakawa, KM Saif-Ur-Rahman, Tomoka Sakaguchi, Chifa Chiang, Hiroshi Yatsuya

BMC Health Services Research Vol. 22 ( 1 ) page： 184 2022.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan.

Methods

This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data.

Findings

Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others.

Conclusions

This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

DOI： 10.1186/s12913-022-07606-1

Other Link： https://link.springer.com/article/10.1186/s12913-022-07606-1/fulltext.html

Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh Reviewed Open Access

Al-Shoaibi, AAA; Chiang, CF; Khalequzzaman, M; Choudhury, SR; Hirakawa, Y; Islam, SS; Aoyama, A; Yatsuya, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 1 ) page： 69 - 79 2022.2

Language：English Publisher：Nagoya Journal of Medical Science

This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

DOI： 10.18999/nagjms.84.1.69

Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament Reviewed Open Access

Nakashima, H; Imagama, S; Yoshii, T; Egawa, S; Sakai, K; Kusano, K; Nakagawa, Y; Hirai, T; Wada, K; Katsumi, K; Fujii, K; Kimura, A; Furuya, T; Kanchiku, T; Nagamoto, Y; Oshima, Y; Nagoshi, N; Ando, K; Takahata, M; Mori, K; Nakajima, H; Murata, K; Matsunaga, S; Kaito, T; Yamada, K; Kobayashi, S; Kato, S; Ohba, T; Inami, S; Fujibayashi, S; Katoh, H; Kanno, H; Li, YY; Yatsuya, H; Koda, M; Kawaguchi, Y; Takeshita, K; Matsumoto, M; Yamazaki, M; Okawa, A

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 748 2022.1

Language：English Publisher：Scientific Reports

This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

DOI： 10.1038/s41598-021-04727-1

Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study International journal Open Access

Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

Journal of Atherosclerosis and Thrombosis Vol. 29 ( 10 ) page： 1547 - 1562 2022

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

<p> <b>Aim:</b> We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.</p><p><b>Methods:</b> We studied 102,535 participants aged 40–79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (＜18.5, 18.5–20.9, 21.0–22.9 [reference], 23.0–24.9, 25.0–27.4, and ≥ 27.5 kg/m<sup>2</sup>) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.</p><p><b>Results:</b> During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25–27.4 and ≥ 27.5 kg/m<sup>2</sup>) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m<sup>2</sup> for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.</p><p><b>Conclusion:</b> A BMI ≥ 25 kg/m<sup>2</sup> is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.</p>

DOI： 10.5551/jat.63143

Change in the Number of Patient Safety Reports Through a 16-Year Patient Safety Initiative: A Retrospective Study Focusing on the Incident Severity and Type in a Japanese Hospital. Reviewed International journal Open Access

Daisuke Koike, Masahiro Ito, Akihiko Horiguchi, Hiroshi Yatsuya, Atsuhiko Ota

Risk management and healthcare policy Vol. 15 page： 2071 - 2081 2022

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To describe the long-term quantitative change in the number of submissions of patient safety reports after the introduction of a patient safety reporting system, focusing on incident severity and type. PATIENTS AND METHODS: This study was performed at a tertiary care hospital in Japan. Patient safety reports from 2006 to 2020 were retrospectively reviewed. Incident severity was classified from level 0 (near miss) to level 5 (fatality). The incident types included those related to medication, patient care, drains and catheters, procedures and interventions, examinations, medical devices, and blood transfusions. The study period was divided into 1. 2004-2007; 2. 2008-2014; and 3. 2015-2020 based on the implementation of hospital patient safety strategies. The number of reports per hospital worker was compared among the study periods and the incident levels and types. RESULTS: We analyzed 96,332 reports extracted from the patient safety reporting system of the hospital. The total number of reports per hospital worker has increased over time. The numbers of levels 0 and 1 incidents increased throughout the study period. In addition, levels 3a and 3b incidents increased between periods 2 and 3. All incident types, except for procedure and intervention-related incidents, increased between periods 1 and 2 and between periods 1 and 3. The number of procedure and intervention-related incidents increased between periods 2 and 3, although it did not between periods 1 and 2. CONCLUSION: We found increases in the number of patient safety reports according to the incident severity and type. This suggests two contextual changes occurring during the cultural maturity process, which reflected the development of organizational patient safety culture in our institution. The first was the establishment of a reporting attitude in the institution. The second was to overcome barriers to patient safety.

DOI： 10.2147/RMHP.S385453

Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population Reviewed International journal Open Access

Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, Hiroshi Yatsuya, Tomonori Okamura

Journal of the American Heart Association Vol. 10 ( 23 ) 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

<sec xml:lang="en">
<title>Background</title>
<p xml:lang="en">Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors.

</sec>
<sec xml:lang="en">
<title>Methods and Results</title>
<p xml:lang="en">We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol <4.65 mmol/L, systolic blood pressure <120 mm Hg, diastolic blood pressure <80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%–11.9%] versus 19.4% [16.7%–21.4%] for men and 6.9% [1.2%–11.5%] versus 15.4% [12.6%–18.1%] for women).

</sec>
<sec xml:lang="en">
<title>Conclusions</title>
<p xml:lang="en">The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.

</sec>

DOI： 10.1161/jaha.121.021753

Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. Reviewed International journal Open Access

Atsuhiko Ota, Yuanying Li, Hiroshi Yatsuya, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Yoko Sou, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki Iwasaki, Norie Sawada, Shoichiro Tsugane

Journal of cancer survivorship : research and practice Vol. 15 ( 6 ) page： 912 - 921 2021.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study compared working cancer survivors' self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. METHODS: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. RESULTS: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39-1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16-1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34-2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56-2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01-1.45)) but not in women (76.1% vs. 74.9%). CONCLUSIONS: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. IMPLICATIONS FOR CANCER SURVIVORS: Continuous support to improve cancer survivors' SRHS and physical functional capacity would be necessary even while they are working.

DOI： 10.1007/s11764-020-00984-7

The association of work-related stress according to the demand-control model with aggravation of pre-existing disease during the first state of COVID-19 emergency in Japan. Open Access

Yupeng He, Hiroshi Yatsuya, Chifa Chiang, Atsuhiko Ota, Ryo Okubo, Tomohiro Ishimaru, Takahiro Tabuchi

Journal of epidemiology Vol. 31 ( 12 ) page： 635 - 640 2021.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Epidemiological Association

BACKGROUND: The job environment has changed a lot during the period of coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the association between work-related stress and aggravation of pre-existing disease in workers during the first state of COVID-19 emergency in Japan. METHODS: Data were obtained from a large internet survey conducted between August 25 and September 30, 2020 in Japan. Participants who reported that they had a job as well as current history of disease(s) (i.e., pre-existing conditions) were included (n=3090). Aggravation of pre-existing disease during the state of emergency was self-reported. Work-related stress from April 2020 (since the state of COVID-19 emergency) was assessed according to job demand-control model. Multivariable logistic regression models were used to analyze the association. RESULTS: Aggravation of pre-existing diseases was reported by 334 participants (11%). The numbers of participants with high demand and low control were 112 (18%) and 100 (14%), respectively. Compared to medium demand, high demand was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.77, 95% confidence interval: 1.30-2.42). Low control compared to medium control was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.39, 95% confidence interval: 1.02-1.92). CONCLUSION: Work-related stress during the first state of COVID-19 emergency was associated with aggravation of pre-existing disease during that period.

DOI： 10.2188/jea.JE20210146

Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration Reviewed

Hiroki Kaneko, Noriko Takashi, Masaaki Matsunaga, Yasuki Ito, Jun Takeuchi, Hiroko Terasaki, Hiroshi Yatsuya, Koji M. Nishiguchi

Graefe's Archive for Clinical and Experimental Ophthalmology Vol. 259 ( 12 ) page： 3589 - 3596 2021.12

Language：English Publishing type：Research paper (scientific journal)

Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

DOI： 10.1007/s00417-021-05280-3

Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study. Reviewed International journal Open Access

Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

Stroke Vol. 52 ( 11 ) page： 3543 - 3550 2021.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

DOI： 10.1161/STROKEAHA.120.031212

Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study. Reviewed International journal

Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

Atherosclerosis Vol. 335 page： 1 - 7 2021.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIMS: The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort. METHODS: A total of 56,381 adults aged 45-74 years were divided into the non-hobby, having a hobby, and having many hobbies groups. We performed Cox proportional hazard models to estimate the hazard ratio (HRs) for incident CVD, CHD, and stroke after adjusting for potential confounding factors. RESULTS: We identified 3685 incident CVDs (940 CHDs and 2839 strokes) during a median follow-up of 16.3 years. After multivariable adjustment, compared to the non-hobby group, participants having a hobby and many hobbies had a 10% (HR = 0.90 [0.83, 0.97]) and 20% (HR = 0.80 [0.69, 0.93]) lower risk of CVD incidence, respectively. The risk of CHD was lower in those with many hobbies, but the association between having many hobbies and CHD risk was not statistically significant. We also found a similar inverse association for stroke. Compared to the non-hobby group, participants having a hobby and many hobbies had a 13% (HR = 0.87 [0.80, 0.96]) and 20% (HR = 0.80 [0.68, 0.94]) lower risk of stroke. CONCLUSIONS: Having hobbies was associated with a lower risk of CVD. Engagement in hobbies may emerge as an important target for healthy lifestyle promotion for the primary prevention of CVD.

DOI： 10.1016/j.atherosclerosis.2021.09.002

アポリポ蛋白A2のアイソフォームと心筋梗塞発症との関連に関するコホート内症例対照研究多目的コホート(JPHC)研究

木原朋未, 山岸良匡, 本田一文, 池田愛, 八谷寛, 斉藤功, 小久保喜弘, 山地太樹, 島津太一, 澤田典絵, 岩崎基, 磯博康, 津金昌一郎

日本動脈硬化学会総会プログラム・抄録集 Vol. 53回 page： 232 - 232 2021.10

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 Open Access

Feigin, VL; Stark, BA; Johnson, CO; Roth, GA; Bisignano, C; Abady, GG; Abbasifard, M; Abbasi-Kangevari, M; Abd-Allah, F; Abedi, V; Abualhasan, A; Abu-Rmeileh, NM; Abushouk, A; Adebayo, OM; Agarwal, G; Agasthi, P; Ahinkorah, BO; Ahmad, S; Ahmadi, S; Salih, YA; Aji, B; Akbarpour, S; Akinyemi, RO; Al Hamad, H; Alahdab, F; Alif, SM; Alipour, V; Aljunid, SM; Almustanyir, S; Al-Raddadi, RM; Salman, RAS; Alvis-Guzman, N; Ancuceanu, R; Anderlini, D; Anderson, JA; Ansar, A; Antonazzo, IC; Arabloo, J; Ärnlöv, J; Artanti, KD; Aryan, Z; Asgari, S; Ashraf, T; Athar, M; Atreya, A; Ausloos, M; Baig, AA; Baltatu, OC; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Barone, MTU; Basu, S; Bazmandegan, G; Beghi, E; Beheshti, M; Béjot, Y; Bell, AW; Bennett, DA; Bensenor, IM; Bezabhe, WM; Bezabih, YM; Bhagavathula, AS; Bhardwaj, P; Bhattacharyya, K; Bijani, A; Bikbov, B; Birhanu, MM; Boloor, A; Bonny, A; Brauer, M; Brenner, H; Bryazka, D; Butt, ZA; dos Santos, FLC; Campos-Nonato, IR; Cantu-Brito, C; Carrero, JJ; Castañeda-Orjuela, CA; Catapano, AL; Chakraborty, PA; Charan, J; Choudhari, SG; Chowdhury, EK; Chu, DT; Chung, SC; Colozza, D; Costa, VM; Costanzo, S; Criqui, MH; Dadras, O; Dagnew, B; Dai, X; Dalal, K; Damasceno, AAM; D'Amico, E; Dandona, L; Dandona, R; Gela, JD; Davletov, K; De La Cruz-Góngora, V; Desai, R; Dhamnetiya, D; Dharmaratne, SD; Dhimal, ML; Dhimal, M; Diaz, D; Dichgans, M; Dokova, K; Doshi, R; Douiri, A; Duncan, BB; Eftekharzadeh, S; Ekholuenetale, M; El Nahas, N; Elgendy, IY; Elhadi, M; El-Jaafary, S; Endres, M; Endries, AY; Erku, DA; Faraon, EJA; Farooque, U; Farzadfar, F; Feroze, AH; Filip, I; Fischer, F; Flood, D; Gad, MM; Gaidhane, S; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Ghozy, S; Gialluisi, A; Giampaoli, S; Gilani, SA; Gill, PS; Gnedovskaya, E; Golechha, M; Goulart, AC; Guo, YM; Gupta, R; Gupta, VB; Gupta, VK; Gyanwali, P; Hafezi-Nejad, N; Hamidi, S; Hanif, A; Hankey, GJ; Hargono, A; Hashi, A; Hassan, TS; Hassen, HY; Havmoeller, RJ; Hay, S; 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Yonemoto, N; Yu, CH; Yunusa, I; Zaman, MS; Bin Zaman, S; Zamanian, M; Zand, R; Zandifar, A; Zastrozhin, MS; Zastrozhina, A; Zhang, Y; Zhang, ZJ; Zhong, C; Zuniga, YMH; Murray, CJL

LANCET NEUROLOGY Vol. 20 ( 10 ) page： 795 - 820 2021.10

Publisher：Lancet Neurology

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.

DOI： 10.1016/S1474-4422(21)00252-0

Association of anthropometric indices of obesity with hypertension among public employees in northern Ethiopia: Findings from a cross-sectional survey Reviewed International coauthorship Open Access

K. M. Saif-Ur-Rahman, Chifa Chiang, Lemlem Weldegerima Gebremariam, Esayas Haregot Hilawe, Yoshihisa Hirakawa, Atsuko Aoyama, Hiroshi Yatsuya

BMJ Open Vol. 11 ( 9 ) page： e050969 2021.9

Language：English Publisher：BMJ Publishing Group

Objectives: The burden of hypertension is increasing in low-income countries, including Ethiopia. Obesity is widely known to be associated with hypertension, but different anthropometric indices of obesity might differ in association with hypertension, which is largely unknown in northern Ethiopia. Design: Data from our previous cross-sectional epidemiological survey were statistically analysed. Setting: Public employees in the regional capital city in northern Ethiopia. Participants: The data of 1380 participants (823 men and 557 non-pregnant women) aged 25 and 64 years were analysed. Outcome measures: The presence of hypertension was the outcome measure and multivariable-adjusted logistic regression analyses were used to investigate the association of body mass index (BMI), waist circumference, and waist-hip ratio in men and women separately. The area under the curve (AUC) for three anthropometric indices for discriminating hypertension was also obtained. Separate analyses were conducted for waist circumference and waist-hip ratio analyses further adjusted for BMI. Results: BMI was linearly associated with hypertension in men (OR for 1 SD increase in BMI 1.45, p=0.001) and women (OR for 1 SD increase in BMI 1.41, p=0.01). The association of waist circumference was independent of BMI both in men (OR for 1 SD increase in waist circumference: 1.74, p=0.002) and women (OR for 1 SD increase in waist circumference: 1.57, p=0.029). The association of waist-hip ratio with hypertension adjusted for BMI was significant in men (OR for 1 SD increase in the waist-hip ratio: 1.46, p&lt
0.001), but was weak and non-significant in women. The AUC for BMI was 0.64 in men and 0.67 in women, while AUC for waist circumference was 0.69 both in men and women. Conclusions: Waist circumference was associated with hypertension independent of BMI among public employees in northern Ethiopia.

DOI： 10.1136/bmjopen-2021-050969

Associations of insomnia with noise annoyance and neighborhood environments: A nationwide cross-sectional study in Japan. Reviewed International journal Open Access

Tomoya Hanibuchi, Tomoki Nakaya, Tsuyoshi Kitajima, Hiroshi Yatsuya

Preventive medicine reports Vol. 23 page： 101416 - 101416 2021.9

Language：English Publishing type：Research paper (scientific journal)

Despite the increasing knowledge on the association between neighborhood and health, few studies have investigated sleep disorders in Japan, particularly the impact of neighborhood noise on sleep. Thus, this study aimed to investigate the associations between insomnia symptoms and annoyance because of traffic and neighborhood noise in Japan, which has different neighborhood conditions compared with those of the western societies. Neighborhood built and socioeconomic environments roles were also examined. We used nationwide cross-sectional data collected through a 2015 online survey of Japanese adults aged 20-64 years (n = 4,243). Adjusted prevalence ratios for insomnia according to the exposures were estimated using the multilevel Poisson regression models. The results showed that having insomnia was significantly associated with experiencing neighborhood and traffic-noise annoyance. Neighborhood noise had a stronger and independent association with insomnia. However, the neighborhood environmental variables, including population density, deprivation index, and access to commercial areas, were not associated with insomnia. In conclusion, noise annoyance, particularly that sourced from neighbors, is an important factor in relation to sleep health. Health and urban-planning policymakers should consider neighborhood noise, in addition to traffic noise, as health-related issues in residential neighborhoods.

DOI： 10.1016/j.pmedr.2021.101416

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study

Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY Vol. 50 2021.9

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