研究者詳細 - 大平　英樹

Cytokines are important mediators of various stress-related modulations of immune function. A major genetic factor determining inter-individual differences in stress reactivity is polymorphisms of the serotonin (5-hydroxytryptamine, 5HT) transporter (5HTT) gene. A short (S) variant, compared with a long (L) variant, of the promoter region of the 5HTT gene-linked polymorphic region (5HTTLPR) has been related to emotional and stress hyper-reactivity. The present study examined whether the 5HTTLPR can modulate responses of inflammatory cytokines under acute stress. Nine Japanese male participants carrying two copies of the S alleles and nine Japanese males carrying S and L alleles underwent the Trier Social Stress Test (TSST). Inflammatory cytokines, endocrine parameters, heart rate and subjective stress were measured before, during and after the task. The participants carrying the SS alleles, but not those carrying the SL alleles, showed a significant increase of IL-1β immediately after TSST. This hyper-reactivity to acute stress in individuals with the SS alleles was also observed in their heart rate and cortisol levels. These results suggest that the S allele of the 5HTTLPR is consistently associated with stress reactivity in multi-level stress-related biological systems.

DOI： 10.1038/srep13852

Web of Science

Scopus

PubMed

Insular neural system controls decision-making in healthy and methamphetamine-treated rats.

Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K

Proceedings of the National Academy of Sciences of the United States of America 112 巻 ( 29 ) 頁： E3930 - 9 2015年7月

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Mizoguchi H., Katahira K., Inutsuka A., Fukumoto K., Nakamura A., Wang T., Nagai T., Sato J., Sawada M., Ohira H., Yamanaka A., Yamada K.

Proceedings of the National Academy of Sciences of the United States of America 112 巻 ( 29 ) 頁： E3930 - E3939 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Proceedings of the National Academy of Sciences of the United States of America

Patients suffering from neuropsychiatric disorders such as substance-related and addictive disorders exhibit altered decision-making patterns, which may be associated with their behavioral abnormalities. However, the neuronal mechanisms underlying such impairments are largely unknown. Using a gambling test, we demonstrated that methamphetamine (METH)-treated rats chose a high-risk/high-reward option more frequently and assigned higher value to high returns than control rats, suggestive of changes in decision-making choice strategy. Immunohistochemical analysis following the gambling test revealed aberrant activation of the insular cortex (INS) and nucleus accumbens in METH-treated animals. Pharmacological studies, together with in vivo microdialysis, showed that the insular neural system played a crucial role in decision-making. Moreover, manipulation of INS activation using designer receptor exclusively activated by designer drug technology resulted in alterations to decision-making. Our findings suggest that the INS is a critical region involved in decision-making and that insular neural dysfunction results in risk-taking behaviors associated with altered decision-making.

DOI： 10.1073/pnas.1418014112

Scopus

Insular neural system controls decision-making in healthy and methamphetamine-treated rats

Mizoguchi Hiroyuki, Katahira Kentaro, Inutsuka Ayumu, Fukumoto Kazuya, Nakamura Akihiro, Wang Tian, Nagai Taku, Sato Jun, Sawada Makoto, Ohira Hideki, Yamanaka Akihiro, Yamada Kiyofumi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 巻 ( 29 ) 頁： E3930 - E3939 2015年7月

Insular neural system controls decision-making in healthy and methamphetamine-treated rats. 査読有り

2015年7月

Insular neural system controls decision-making in healthy and methamphetamine-treated rats 査読有り

Hiroyuki Mizoguchi, Kentaro Katahira, Ayumu Inutsuka, Kazuya Fukumoto, Akihiro Nakamura, Tian Wang, Taku Nagai, Jun Sato, Makoto Sawada, Hideki Ohira, Akihiro Yamanaka, Kiyofumi Yamada

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 巻 ( 29 ) 頁： E3930 - E3939 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATL ACAD SCIENCES

DOI： 10.1073/pnas.1418014112

Web of Science

Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva 査読有り

Oikawa, J; Ukawa, S; Ohira, H; Kawamura, T; Wakai, K; Ando, M; Hata, A; Tamakoshi, A

JOURNAL OF EPIDEMIOLOGY 25 巻 ( 7 ) 頁： 470 - 474 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本疫学会 (Japan Epidemiological Association) JEA

Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people. Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status. Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 mu g/min vs 15.0 mu g/min, P = 0.03), even after elimination of the effects of possible confounders. Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.

DOI： 10.2188/jea.JE20140088

社会経済地位とこころの健康の関連性ストレスマーカー炎症性サイトカインを用いて

山川香織, 松永昌宏, 大平英樹

東海学園大学研究紀要(人文科学研究編) ( 20 ) 頁： 85 - 91 2015年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：東海学園大学

近年、主観的に社会経済地位(subjective Social Economics Status:sSES)を低く評価している人は精神的健康のトラブルを引き起こしやすいということが報告されている。その背景には社会心理的ストレスが関係しているとし、ストレスマーカーによる知見が蓄積されているが、未だ不明な点が多い。本研究ではストレスマーカーとして炎症性サイトカインを用い、主観的社会経済地位と精神的健康の関連性について検討を行った。この結果、低い社会経済的地位の評価が高い炎症性サイトカイン値を示すことが明らかとなった。さらに、男性においてのみ社会経済地位と炎症性サイトカインとの間に負の相関が認められた。本研究によって、男性における社会経済地位の健康問題に炎症性サイトカインが寄与する可能性が示唆された。(著者抄録)

Do the letters F, A and S represent Indonesian letter fluency stimuli?

Hendrawan, D; Hatta, T; Ohira, H

ASIA-PACIFIC PSYCHIATRY 7 巻 ( 1 ) 頁： 64 - 71 2015年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Asia-Pacific Psychiatry

Introduction: The letters F, A and S, originally used in the English letter fluency stimuli test, have been frequently adopted to assess executive function in many languages. However, few studies reported the significance of FAS testing employed in different languages. The current study explored whether FAS could be widely applied to the Indonesian language. Methods: A total of 211 undergraduate students from state and private universities who participated in this study were randomly assigned into four groups. Each group was exposed to six different letter fluency stimuli. The total number of words the participants produced for each letter stimulus were averaged and ranked to determine the degree of difficulty in generating words. Furthermore, the normal distribution and equal ratio comparison were examined to verify the representative letter fluency stimuli. In addition, the effect of sex and university affiliation on letter fluency performance was also analyzed. Results: The letters A and S were among the easiest letters used to generate words; however, the letter F was regarded as a difficult stimulus. Furthermore, only the number of words beginning the letter S was distributed according to a normal curve. The number of words starting with the letters F and A were not normally distributed. Although sex difference was not associated with letter fluency performance, difference in university affiliation showed a significant effect on performance. Discussion: Our findings suggest that consideration of several stimuli factors is required to accurately measure performance in the letter fluency task in a specific language.

DOI： 10.1111/appy.12082

Web of Science

Scopus

PubMed

Valence-separated representation of reward prediction error in feedback-related negativity and positivity. 査読有り

Bai, Y., Katahira, K., & Ohira, H.

Neuroreport 26 巻 ( 3 ) 頁： 157-162 2015年2月

Valence-separated representation of reward prediction error in feedback-related negativity and positivity.

Bai Y, Katahira K, Ohira H

Neuroreport 26 巻 ( 3 ) 頁： 157 - 62 2015年2月

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