研究者詳細 - 大平　英樹

論文 - 大平　英樹

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THE STRUCTURE OF THE MINDFUL BRAIN

Murakami Hiroki, Nakao Takashi, Matsunaga Masahiro, Kasuya Yukinori, Shinoda Jun, Yamada Jitsuhiro, Ohira Hideki

PSYCHOPHYSIOLOGY 46 巻頁： S41 - S41 2009年9月

Regulation of natural killer cell redistribution by prefrontal cortex during stochastic learning

Ohira Hideki, Fukuyama Seisuke, Kimura Kenta, Nomura Michio, Isowa Tokiko, Ichikawa Nacho, Matsunaga Masahiro, Shinoda Jun, Yamada Jitsuhiro

NEUROIMAGE 47 巻 ( 3 ) 頁： 897 - 907 2009年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NeuroImage

Acute stress elicits redistribution of lymphocyte subsets, especially natural killer (NK) cells, probably for preparatory defense against potential invasion of antigens in fight-flight situations. We previously reported that regulation of lymphocyte redistribution is based on the evaluation of the controllability of a stressor (Kimura, K., Ohira, H., Isowa, T., Matsunaga, M., Murashima, S. 2007. Regulation of lymphocytes redistribution via autonomic nervous activity during stochastic learning. Brain Behav. Immun. 21, 921-934; Ohira, H., Isowa, T., Nomura, M., Ichikawa, N., Kimura, K., Miyakoshi, M., Iidaka, T., Fukuyama, S., Nakajima, T., Yamada, J. 2008. Imaging brain and immune association accompanying cognitive appraisal of an acute stressor. Neuroimage 39, 500-514). Specifially, lymphocyte redistribution is somewhat attenuated when a stressor is uncontrollable, probably to save biological energy in a situation where appropriate coping is unclear. We infer that this phenomenon might reflect top-down regulation over peripheral immune function by higher-ordered brain regions. To investigate the neural basis of such a phenomenon, we simultaneously recorded regional cerebral blood flow using 15O-water positron emission tomography and cardiovascular (blood pressure and heart rate), neuroendocrine (epinephrine, norepinephrine, and adrenocorticotropic hormone), and immune (proportions of NK cells and helper T cells in blood) indices in 16 male subjects who performed a stochastic learning task with manipulation of controllability (controllable vs. uncontrollable). Consistent with previous studies, the proportion of peripheral NK cells was attenuated in an uncontrollable stress condition. The dorsolateral prefrontal and orbitofrontal cortices were activated in the uncontrollable situation but not in the controllable condition, and additionally, these prefrontal brain regions significantly correlated with the degree of redistribution of NK cells in the uncontrollable condition. The results of the study suggest these brain regions are involved in both evaluation of the controllability of a stressor and regulation of immune function. © 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.neuroimage.2009.04.088

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PubMed

PREFRONTAL CORTEX MODULATES PERIPHERAL IMMUNE FUNCTION ACCORDING TO CONTROLLABILITY OF ACUTE STRESS

Ohira Hideki, Kimura Kenta, Nomura Michio, Isowa Tokiko, Ichikawa Naho, Matsunaga Masahiro, Fukuyama Seisuke, Shinoda Jun, Yamada Jitsuhiro

PSYCHOPHYSIOLOGY 46 巻頁： S41 - S41 2009年9月

PREFRONTAL CORTEX MODULATES PERIPHERAL IMMUNE FUNCTION ACCORDING TO CONTROLLABILITY OF ACUTE STRESS 査読有り

Hideki Ohira, Kenta Kimura, Michio Nomura, Tokiko Isowa, Naho Ichikawa, Masahiro Matsunaga, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada

PSYCHOPHYSIOLOGY 46 巻頁： S41 - S41 2009年9月

NEURAL BASES OF BEHAVIOR SELECTION WITHOUT AN OBJECTIVE CORRECT ANSWER

Nakao Takashi, Osumi Takahiro, Ohira Hideki, Kasuya Yukinori, Shinoda Jun, Yamada Jitsuhiro

PSYCHOPHYSIOLOGY 46 巻頁： S41 - S41 2009年9月

ENGAGING IN A COGNITIVE TASK INHIBITS NEGATIVE EMOTION

Iida, S; Ohira, H

PSYCHOPHYSIOLOGY 46 巻頁： S53 - S53 2009年9月

DUAL DEFICIT IN PSYCHOPATHY: NEURAL CORRELATES OF PSYCHOPATHIC TRAITS WITHIN SOCIAL EXCHANGE

Osumi, T; Nakao, T; Ohira, H; Kasuya, Y; Shinoda, J; Yamada, J

PSYCHOPHYSIOLOGY 46 巻頁： S153 - S154 2009年9月

AFFECTIVE PRIMING IN ERP: UNCONSCIOUS AND CONSCIOUS PROCESSING OF FACIAL EXPRESSIONS AND CULTURAL EFFECTS

Kondo, H; Okita, T; Ohira, H

PSYCHOPHYSIOLOGY 46 巻頁： S40 - S41 2009年9月

視覚システムは感覚刺激系列内の規則性を自動的に保持する

木村元洋, 大平英樹

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： 2AM043 - 2AM043 2009年8月

精神神経内分泌免疫学におけるサイトカイン

木村健太, 大平英樹, 津田彰, 関山敦生, 山川香織

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： WS060 - WS060 2009年8月

視-触覚間統合処理の電気生理的基盤の検討

金山範明, 大平英樹

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： L015 - L015 2009年8月

認知課題による不快感情の制御

飯田沙依亜, 大平英樹

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： 1AM117 - 1AM117 2009年8月

不公正な扱いに対する神経活動とサイコパシーの関連

大隅尚広, 中尾敬, 大平英樹

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： 1AM050 - 1AM050 2009年8月

こころと身体の相互作用

村上裕樹, 大平英樹, 松永昌宏, 矢島潤平, 岩永誠

日本心理学会大会発表論文集 73 巻 ( 0 ) 頁： WS102 - WS102 2009年8月

*Polymorphism of the serotonin transporter gene modulates brain and physiological responses to acute stress in Japanese men 査読有り

Ohira H, Matsunaga M, Isowa T, Nomura M, Ichikawa N, Kimura K, Kanayama N, Murakami H, Osumi T, Konagaya T, Nogimori T, Fukuyama S, Shinoda J, Yamada J.

Stress in press. 巻 2009年8月

Inhibitory effect of oxytocin on accelerated colonic motility induced by water-avoidance stress in rats

Matsunaga M., Konagaya T., Nogimori T., Yoneda M., Kasugai K., Ohira H., Kaneko H.

NEUROGASTROENTEROLOGY AND MOTILITY 21 巻 ( 8 ) 頁： 856 - + 2009年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neurogastroenterology and Motility

Recent studies have indicated that brain and gut activities are interrelated and exposure to several stressors, such as water-avoidance stress, stimulates the motor function of the gut through corticotropin-releasing factor (CRF)-signalling pathways in the brain. Central oxytocin is known to attenuate stress responses, including CRF expression in the brain. Here, we examined whether central oxytocin attenuated the acceleration of colonic motility induced by water-avoidance stress. A force transducer was attached to the distal colon of male rat, and the colonic motility and faecal pellet output were recorded while the rats were exposed to water-avoidance stress. Intracerebroventricular (i.c.v.) injections of oxytocin (5, 50 and 500 pmol) and the oxytocin receptor antagonist tocinoic acid (25 μg) were administered before exposure to water-avoidance stress, and the effect of oxytocin on colonic motor function was determined. Centrally administered oxytocin inhibited the accelerated colonic motility induced by water-avoidance stress. The effective dose ranged between 5 and 50 pmol on i.c.v. injection. Oxytocin also decreased the number of CRF-positive cells in the paraventricular nucleus and corticosterone release. The inhibitory effect of oxytocin on accelerated colonic motility was blocked by pretreatment with oxytocin receptor antagonist. Furthermore, centrally administered tocinoic acid enhanced the acceleration of colonic motility. These results suggested that endogenous central oxytocin may contribute to the regulation of colonic function and inhibit the brain CRF-signalling pathways targeting the gut, resulting in the inhibition of stress-induced colonic contractions. © 2009 Blackwell Publishing Ltd.

DOI： 10.1111/j.1365-2982.2009.01286.x

Web of Science

Scopus

Neural bases of behavior selection without an objective correct answer

Nakao Takashi, Osumi Takahiro, Ohira Hideki, Kasuya Yukinori, Shinoda Jun, Yamada Jitsuhiro

NEUROSCIENCE LETTERS 459 巻 ( 1 ) 頁： 30 - 34 2009年7月

Neural bases of behavior selection without an objective correct answer

Nakao T., Osumi T., Ohira H., Kasuya Y., Shinoda J., Yamada J.

Neuroscience Letters 459 巻 ( 1 ) 頁： 30 - 34 2009年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroscience Letters

Life choice (e.g. occupation choice) often includes situations with two or more possible answers. How does the brain respond to such conflict-ridden situations? We investigated whether the dorsal anterior cingulate cortex (dACC) evaluates the degree of conflict between possible answers. Additionally, we investigated whether the medial prefrontal cortex (MPFC) or the medial temporal lobe (MTL) has a function in behavior selection with plural possible answers. We used an occupational choice task (e.g. which occupation do you think you could do better?-dancer or chemist) with two possible answers and a word-length task (e.g. which word is longer?-dentist or comedian) that has a correct answer. The conflicts in each task were manipulated. Results showed that the dACC and the MTL were activated when the conflict during occupational choice was large, and that the MPFC and posterior cingulate cortex were activated more in the occupational choice task than in the word-length task. Our results show that the dACC evaluates the degree of conflict between possible answers, and that the MTL, MPFC, and posterior cingulate cortex have a function in behavior selection without an objective correct answer. It is thought that the MTL functions to reduce conflict when a large-conflict is detected in the dACC. Furthermore, the MPFC and posterior cingulate are thought to have a function of biasing any of the plural answers in behavior selection without an objective answer. © 2009 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2009.04.056

Scopus

Neural bases of behavior selection without an objective correct answer. 査読有り

Nakao T, Osumi T, Ohira H, Kasuya Y, Shinoda J, Yamada J.

Neuroscience Letters 459 巻 ( 1 ) 頁： 30-34 2009年7月

*Brain and autonomic association accompanying stochastic decision-making 査読有り

Ohira H, Ichikawa N, Nomura M, Isowa T, Kimura K, Kanayama N, Fukuyama S, Shinoda J, Yamada J.

Neuroimage 49 巻 ( 1 ) 頁： 1024-1037 2009年7月

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