研究者詳細 - 田岡　俊昭

Long-term treatment outcomes after intravascular ultrasound evaluation and stent placement for atherosclerotic subclavian artery obstructive lesions.

Wada T, Takayama K, Taoka T, Nakagawa H, Myouchin K, Miyasaka T, Akashi T, Sakamoto M, Kichikawa K

The neuroradiology journal 27 巻 ( 2 ) 頁： 213 - 21 2014年4月

Long-term treatment outcomes after intravascular ultrasound evaluation and stent placement for atherosclerotic subclavian artery obstructive lesions

Wada T., Takayama K., Taoka T., Nakagawa H., Myouchin K., Miyasaka T., Akashi T., Sakamoto M., Kichikawa K.

Neuroradiology Journal 27 巻 ( 2 ) 頁： 213 - 221 2014年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroradiology Journal

The objective of this study was to determine long-term outcomes after stent placement for subclavian artery (SA) obstructive lesions assisted by intraoperative intravascular ultrasound (IVUS). The study included 25 lesions in 24 patients who underwent stent placement assisted by intraoperative IVUS for subclavian artery stenosis or obstruction at our hospital between January 2003 and August 2010. Outcome was evaluated based on the results within 30 postoperative days (technical success rate, improvement in upper extremity ischemia, steal syndrome, left-right blood pressure difference, and perioperative complications) and the results after 30 postoperative days (incidence of vertebrobasilar artery territory infarction and restenosis). Stent placement and vessel dilatation were successful in all patients, without perioperative complications. Upper extremity ischemia, steal syndrome, and left-right blood pressure difference disappeared in all cases. During follow-up observation (6-96 months; median 51 months), no restenosis occurred at the stent placement site in any patient. In one case, four years after initial treatment, stenosis was noted proximal to the stent placement site. Satisfactory long-term as well as short-term outcomes were achieved after stent placement for SA obstructive lesions assisted by intraoperative IVUS evaluation.

DOI： 10.15274/NRJ-2014-10023

Cerebellar dentate nucleus in progressive supranuclear palsy. 国際誌

Sawa N, Kataoka H, Kiriyama T, Izumi T, Taoka T, Kichikawa K, Ueno S

Clinical neurology and neurosurgery 118 巻頁： 32 - 6 2014年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Neurology and Neurosurgery

Objectives: Some patients with progressive supranuclear palsy (PSP) present with cerebellar dysfunction. Severe degeneration of the cerebellar dentate nucleus (CDN) was evident in these patients. We evaluated signal intensity on MRI in the CDN of PSP patients with or without cerebellar ataxia. Patients and methods: We reviewed the clinical histories and brain MRI studies of 28 patients with clinically probable PSP. Three disease control groups were studied: a group of 28 sex- and age-matched patients with Parkinson's disease (PD), a group of 15 patients with multiple system atrophy with predominant parkinsonian features (MSA-P), and 15 control subjects. Turbo spin-echo sequences for T2-weighted images were used using a 1.5 T magnetic resonance imager. Results: Eight patients with PSP (28%) and one patient with MSA-P (6%) had heterogeneous regions in the CDN. This finding was not evident in the patients with PD or controls. Three out of four PSP patients with cerebellar ataxia had heterogeneous regions in the CDN and other one patient with cerebellar ataxia as the initial and principal symptoms had no heterogeneous regions in the CDN. Conclusion: Heterogeneous regions in the CDN on MRI do not always reflect cerebellar ataxia in PSP patients, and this finding might be an additional marker to support a probable diagnosis of PSP. © 2014 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.clineuro.2013.12.011

Decision-making deficit of a patient with axonal damage after traumatic brain injury.

Yasuno F, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Okada K, Tanaka S, Shinkai T, Taoka T, Kishimoto T

Brain and cognition 84 巻 ( 1 ) 頁： 63 - 8 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Brain and Cognition

Patients with traumatic brain injury (TBI) were reported to have difficulty making advantageous decisions, but the underlying deficits of the network of brain areas involved in this process were not directly examined. We report a patient with TBI who demonstrated problematic behavior in situations of risk and complexity after cerebral injury from a traffic accident. The Iowa gambling task (IGT) was used to reveal his deficits in the decision-making process. To examine underlying deficits of the network of brain areas, we examined T1-weighted structural MRI, diffusion tensor imaging (DTI) and Tc-ECD SPECT in this patient. The patient showed abnormality in IGT. DTI-MRI results showed a significant decrease in fractional anisotropy (FA) in the fasciculus between the brain stem and cortical regions via the thalamus. He showed significant decrease in gray matter volumes in the bilateral insular cortex, hypothalamus, and posterior cingulate cortex, possibly reflecting Wallerian degeneration secondary to the fasciculus abnormalities. SPECT showed significant blood flow decrease in the broad cortical areas including the ventromedial prefrontal cortex (VM). Our study showed that the patient had dysfunctional decision-making process. Microstructural abnormality in the fasciculus, likely from the traffic accident, caused reduced afferent feedback to the brain, resulting in less efficient decision-making. Our findings support the somatic-marker hypothesis (SMH), where somatic feedback to the brain influences the decision-making process. © 2013 Elsevier Inc.

DOI： 10.1016/j.bandc.2013.11.005

Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study. Open Access

Kiuchi K, Kitamura S, Taoka T, Yasuno F, Tanimura M, Matsuoka K, Ikawa D, Toritsuka M, Hashimoto K, Makinodan M, Kosaka J, Morikawa M, Kichikawa K, Kishimoto T

PloS one 9 巻 ( 8 ) 頁： e104007 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease. © 2014 Kiuchi et al.

DOI： 10.1371/journal.pone.0104007

Comparison between two separate injections and a single injection of double-dose contrast medium for contrast-enhanced MR imaging of metastatic brain tumors. Open Access

Ochi T, Taoka T, Matsuda R, Sakamoto M, Akashi T, Tamamoto T, Sugimoto T, Sakaguchi H, Hasegawa M, Nakase H, Kichikawa K

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 13 巻 ( 4 ) 頁： 221 - 9 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本磁気共鳴医学会

Purpose: As stereotactic radiotherapy (SRT) becomes widespread, precise information including number, location, and margin of lesions is required when magnetic resonance (MR) imaging of brain metastasis is performed. We compare methods using 2 separate injections and a single injection for the administration of a double dose of contrast medium for contrastenhanced MR imaging.

DOI： 10.2463/mrms.2013-0068

Successful intravenous rt-PA treatment for a patient with basilar artery occlusion manifesting ischemic neurogenic stunned myocardium and ataxic breathing. 査読有り

Tomoyuki Taguchi, Masayuki Fujioka, Shingo Ito, Yasushi Motoyama, Hiroyuki Nakase, Toshiaki Taoka, Kazuo Okuchi

Neurosurgical Emergency 19 巻頁： 220 - 225 2014年

紡錘状椎骨動脈瘤に対するステント併用コイル塞栓術：down-the-barrel view による追加ステント留置術が有用であった1 例 Open Access

和田敬, 高山勝年, 田岡俊昭, 中川裕之, 明珍薫, 木村僚太, 黒川紳一郎, 吉川公彦

脳神経血管内治療 8 巻 ( 4 ) 頁： 218 - 223 2014年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本脳神経血管内治療学会

【目的】紡錘状動脈瘤に対するコイル塞栓術は，通常親血管と動脈瘤を分離できない場合が多いため，親血管を温存した瘤内塞栓術は難しい．ステントを併用したコイル塞栓術で，親血管の内腔を短軸像で確認できる“down-the-barrel view（DBV）”が取れれば，親血管を温存した瘤内塞栓術が可能であったとの報告例がある．紡錘状動脈瘤に対してステントを併用したコイル塞栓術でDBV による追加ステント留置術で親血管を温存して瘤内塞栓術が可能であった1 例を経験したので報告する．【症例】60 歳女性．約1 年前に右椎骨動脈紡錘状動脈瘤を指摘され外来で経過観察されていたが瘤の増大が認められたため，Enterprise stent（EP）を用いたコイル塞栓術を施行した．最初にマイクロカテーテルを瘤内に挿入し，動脈瘤を十分覆うようにEP を留置した後，瘤内塞栓術を施行した．術中親血管へコイルが逸脱しているかどうかの判断が困難となったため，DBV で造影したところステント内腔にコイルの逸脱が認められた．そのためstent-in-stent で新たにEP を追加留置したところ，EP 内のコイル逸脱は消失した．術後合併症は認められなかった．3 カ月後の血管造影で動脈瘤の完全閉塞が認められ，親血管は開存していた．【結論】紡錘状動脈瘤に対するステント併用コイル塞栓術において，DBV による追加ステント留置を行うことで良好な治療効果が得られる例があることが示唆された．

DOI： 10.5797/jnet.cr.13050

Open Access

CiNii Research

A mismatch between the abnormalities in diffusion- and susceptibility-weighted magnetic resonance imaging may represent an acute ischemic penumbra with misery perfusion. 国際誌

Fujioka M, Okuchi K, Iwamura A, Taoka T, Siesjö BK

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 22 巻 ( 8 ) 頁： 1428 - 31 2013年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Stroke and Cerebrovascular Diseases

Susceptibility-weighted imaging (SWI) has recently attracted attention for its ability to investigate acute stroke pathophysiology. SWI detects an increased ratio of deoxyhemoglobin to oxyhemoglobin in cerebral venous compartments, which can illustrate cerebral misery perfusion with a compensatory increase of oxygen extraction fraction in the hypoperfused brain. In this study we make the first case report of blunt cervical trauma leading to a stroke, demonstrating the disparity between diffusion-weighted imaging (DWI) and SWI changes, or DWI-SWI mismatch, in the acute ischemic brain. The area of mismatch between a smaller DWI cytotoxic edema and a larger SWI misery perfusion in our patient matured into a complete infarction with time. The DWI-SWI mismatch may signify the presence of an ischemic penumbra, and provide information about viability of the brain tissue at risk of potential infarction if without early reperfusion. © 2013 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jstrokecerebrovasdis.2012.12.009

Unilateral oculomotor nerve palsy as an initial presentation of bilateral chronic subdural hematoma: Case report

Matsuda R., Hironaka Y., Kawai H., Park Y., Taoka T., Nakase H.

Neurologia Medico-Chirurgica 53 巻 ( 9 ) 頁： 616 - 619 2013年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neurologia Medico-Chirurgica

Isolated oculomotor nerve palsy is well known as a symptom of microvascular infarction and intracranial aneurysm, but unilateral oculomotor nerve palsy as an initial manifestation of chronic subdural hematoma (CSDH) is a rare clinical condition. We report a rare case of an 84-year-old woman with bilateral CSDH who presented with unilateral oculomotor nerve palsy as the initial symptom. The patient, who had a medical history of minor head injury 3 weeks prior, presented with left ptosis, diplopia, and vomiting. She had taken an antiplatelet drug for lacunar cerebral infarction. Computed tomography (CT) of the head showed bilateral CSDH with a slight midline shift to the left side. She underwent an urgent evacuation through bilateral frontal burr holes. Magnetic resonance angiography (MRA) after evacuation revealed no intracranial aneurysms, but constructive interference in steady-state (CISS) magnetic resonance imaging (MRI) revealed that the left posterior cerebral artery (PCA) ran much more anteriorly and inferiorly compared with the right PCA and the left oculomotor nerve passed very closely between the left PCA and the left superior cerebellar artery (SCA). There is the possibility that the strong compression to the left uncus, the left PCA, and the left SCA due to the bilateral CSDH resulted in left oculomotor nerve palsy with an initial manifestation without unconsciousness. Unilateral oculomotor nerve palsy as an initial presentation caused by bilateral CSDH without unconsciousness is a rare clinical condition, but this situation is very important as a differential diagnosis of unilateral oculomotor nerve palsy. © 2013 by The Japan Neurosurgical Society.

DOI： 10.2176/nmc.cr2012-0339

Unilateral Oculomotor Nerve Palsy as an Initial Presentation of Bilateral Chronic Subdural Hematoma: Case Report 査読有り

Ryosuke Matsuda, Yasuo Hironaka, Hisashi Kawai, Young-Su Park, Toshiaki Taoka, Hiroyuki Nakase

NEUROLOGIA MEDICO-CHIRURGICA 53 巻 ( 9 ) 頁： 616 - 619 2013年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN NEUROSURGICAL SOC

Isolated oculomotor nerve palsy is well known as a symptom of microvascular infarction and intracranial aneurysm, but unilateral oculomotor nerve palsy as an initial manifestation of chronic subdural hematoma (CSDH) is a rare clinical condition. We report a rare case of an 84-year-old woman with bilateral CSDH who presented with unilateral oculomotor nerve palsy as the initial symptom. The patient, who had a medical history of minor head injury 3 weeks prior, presented with left ptosis, diplopia, and vomiting. She had taken an antiplatelet drug for lacunar cerebral infarction. Computed tomography (CT) of the head showed bilateral CSDH with a slight midline shift to the left side. She underwent an urgent evacuation through bilateral frontal burr holes. Magnetic resonance angiography (MRA) after evacuation revealed no intracranial aneurysms, but constructive interference in steady-state (CISS) magnetic resonance imaging (MM) revealed that the left posterior cerebral artery (PCA) ran much more anteriorly and inferiorly compared with the right PCA and the left oculomotor nerve passed very closely between the left PCA and the left superior cerebellar artery (SCA). There is the possibility that the strong compression to the left uncus, the left PCA, and the left SCA due to the bilateral CSDH resulted in left oculomotor nerve palsy with an initial manifestation without unconsciousness. Unilateral oculomotor nerve palsy as an initial presentation caused by bilateral CSDH without unconsciousness is a rare clinical condition, but this situation is very important as a differential diagnosis of unilateral oculomotor nerve palsy.

DOI： 10.2176/nmc.cr2012-0339

Longitudinal white matter changes in Alzheimer's disease: a tractography-based analysis study.

Kitamura S, Kiuchi K, Taoka T, Hashimoto K, Ueda S, Yasuno F, Morikawa M, Kichikawa K, Kishimoto T

Brain research 1515 巻頁： 12 - 8 2013年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Brain Research

Alzheimer's disease (AD) classically presents with gray matter atrophy, as well as feature significant white matter abnormalities. Previous evidence indicates the overall burden of these pathological changes continues to advance as the disease progresses. The aim of this study was to investigate whether pathological alterations of white matter tracts correlate with the course of AD disease progression. 35 AD patients and 29 normal controls were recruited to the study and administered baseline magnetic resonance diffusion tensor imaging (DTI) acquisition and a cognitive function assessment at the time of initial evaluation. Subjects were re-evaluated with secondary DTI scan and cognitive function assessment at intervals of about 1.5 years on average. For the DTI acquired scans, we calculated diffusion tensor parameters, fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial diffusivity (DR), and axial diffusivity (DA) along with the uncinate fasciculus (UNC), the inferior longitudinal fasciculus (ILF), and the inferior occipitofrontal fasciculus (IOFF). Compared to baseline, a significant mean FA reduction of the bilateral UNC, as well as a significant mean DR increase of the left UNC, was evident in AD patients at follow-up. Compared with normal controls, AD patients exhibited significant diffusion parameter abnormalities in their UNC, ILF, and IOFF. Taken together, these results indicate that progressive pathological white matter alterations can be quantified using the DTI parameters utilized here and may prove to be a useful biological marker for monitoring the pathophysiological course of AD. © 2013 Elsevier B.V.

DOI： 10.1016/j.brainres.2013.03.052

Unilateral Optic Nerve Hypoplasia with Contralateral Optic Pathway Hypoplasia: A Case Report 査読有り国際誌 Open Access

Nishi, T; Yukawa, E; Taoka, T; Ogata, N

NEURO-OPHTHALMOLOGY 37 巻 ( 3 ) 頁： 116 - 119 2013年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuro-Ophthalmology

Optic nerve hypoplasia is diagnosed by the ophthalmoscopic appearance of the fundus of the eye and by standard magnetic resonance imaging of the brain. The ability to study eyes with optic nerve hypoplasia by magnetic resonance diffusion tensor imaging has improved the evaluation of the optic pathways. The authors report a case of unilateral optic nerve hypoplasia with hypoplasia of the contralateral optic pathway. The entire visual pathway of this patient was examined by magnetic resonance and magnetic resonance diffusion tensor imaging. The images show a decrease of the volume of the optic radiation contralateral to the optic nerve abnormality and also pre- and post-chiasmal abnormalities. © Informa Healthcare USA, Inc.

DOI： 10.3109/01658107.2013.785572

Semi-Jailing法が有用であったEnterprise sentを用いた内頸動脈瘤の2例

和田敬, 高山勝年, 中川裕之, 宮坂俊輝, 明珍薫, 坂本雅彦, 田岡俊昭, 吉川公彦, 中川一郎, 黒川紳一郎

IVR: Interventional Radiology 28 巻 ( Suppl. ) 頁： 155 - 155 2013年4月

Movement disorders 査読有り

Taoka T.

Geriatric Imaging 80 巻頁： 675 - 709 2013年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Geriatric Imaging

This chapter reviews disorders that show movement dysfunction. Although these diseases have various mechanisms and include a number of categories, the role of imaging has become increasingly important in clinical practice in the diagnostic assessment of all movement disorders. In addition to standard morphological images, functional images using MRI, diffusion tensor images illustrating white matter structure, and other methods are becoming increasingly important in initial diagnosis as well as ongoing monitoring and assessment during treatment. In addition to the importance of imaging, information about genetics is also important for characterizing disease subtypes and for correct diagnosis. In this chapter, clinical, genetic, and pathological findings, as well as imaging findings, are discussed for each disorder. These sections are followed by more recent imaging findings to further evaluate each of the disorders.

DOI： 10.1007/978-3-642-35579-0_25