研究者詳細 - 田岡　俊昭

論文 - 田岡　俊昭

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Optic Tractography in Epilepsy Surgery 査読有り Open Access

Toshiaki Taoka, Tohru Hoshida, Kimihiko Kichikawa, Toshisuke Sakaki

Nosotchu 26 巻 ( 4 ) 頁： 574 - 578 2004年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Stroke Society

Diffusion tensor tractography is a newly developed method for tracing tracts in white matter using combination of diffusion tensor images. We evaluate the degree of impairment of optic tracts in the cases with visual field defect after temporal lobectomy using diffusion tensor tractography. We examined 8 cases after temporal lobectomy for temporal lobe epilepsy. Visual field defect in medial sector and lateral sector of upper 1/4 visual field were evaluated. Diffusion tensor tractography of optic radiation was made from 6 axes diffusion tensor images. We evaluated the correlation between the degree of visual field defect and visualization of Meyer's loop on tractographies. Medial sector field tends to be impaired after temporallobectomy. Diffusion tensor tractography showed incomplete to no visualization of Meyer's loop in the cases with severe visual field defect. While, visualization of optic radiation was almost complete in cases with mild visual field defect. Diffusion tensor tractography was useful in evaluating post surgical changes in optic radiation. Potential usefulness of tractography in surgical planning was also suggested.

DOI： 10.3995/jstroke.26.574

Open Access

CiNii Research

Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration.

Fujioka M, Taoka T, Matsuo Y, Mishima K, Ogoshi K, Kondo Y, Tsuda M, Fujiwara M, Asano T, Sakaki T, Miyasaki A, Park D, Siesjö BK

Annals of neurology 54 巻 ( 6 ) 頁： 732 - 47 2003年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Annals of Neurology

Brief focal ischemia leading to temporary neurological deficits induces delayed hyperintensity on T1-weighted magnetic resonance imaging (MRI) in the striatum of humans and rats. The T1 hyperintensity may stem from biochemical alterations including manganese (Mn) accumulation after ischemia. To clarify the significance of this MRI modification, we investigated the changes in the dorsolateral striatum of rats from 4 hours through 16 weeks after a 15-minute period of middle cerebral artery occlusion (MCAO), for MRI changes, Mn concentration, neuronal number, reactivities of astrocytes and microglia/macrophages, mitochondrial Mn-superoxide dismutase (Mn-SOD), glutamine synthetase (GS), and amyloid precursor protein. The cognitive and behavioral studies were performed in patients and rats and compared with striatal T1 hyperintensity to show whether alteration in brain function correlated with MRI and histological changes. The T1-weighted MRI signal intensity of the dorsolateral striatum increased from 5 days to 4 weeks after 15-minute MCAO, and subsequently decreased until 16 weeks. The Mn concentration of the dorsolateral striatum increased after ischemia in concert with induction of Mn-SOD and GS in reactive astrocytes. The neuronal survival ratio in the dorsolateral striatum decreased significantly from 4 hours through 16 weeks, accompanied by extracellular amyloid precursor protein accumulation and chronic glial/inflammatory responses. The patients and rats with neuroradiological striatal degeneration had late-onset cognitive and/or behavioral declines after brief focal ischemia. This study suggests that (1) the hyperintensity on T1-weighted MRI after mild ischemia may involve tissue Mn accumulation accompanied by Mn-SOD and GS induction in reactive astrocytes, (2) the MRI changes correspond to striatal neurodegeneration with a chronic inflammatory response and signs of oxidative stress, and (3) the subjects with these MRI changes are at risk for showing a late impairment of brain function even though the transient ischemia is followed by total neurological recovery.

DOI： 10.1002/ana.10751

Web of Science

Scopus

PubMed

Vasogenic edema and VEGF expression in a rat two-vein occlusion model.

Kimura R, Nakase H, Sakaki T, Taoka T, Tsuji T

Acta neurochirurgica. Supplement 86 巻頁： 213 - 7 2003年

Progressive MRI change indicates manganese accumulation and striatal neurodegeneration resulting in cognitive decline in humans and rats after brief focal ischemia.

Fujioka M, Taoka T, Matsuo Y, Mishima K, Ogoshi K, Kondo Y, Tsuda M, Fujiwara M, Asano T, Sasaki T, Miyasaki A, Park D, Siesj, BK

Ann Neurol 54 巻頁： 732 - 747 2003年

排尿日誌を利用してスクリーニングした夜間多尿例における視床下部・下垂体後葉機能の検討 Open Access

夏目修, 穴井洋, 田岡俊昭

日本泌尿器科学会雑誌 94 巻 ( 2 ) 頁： 136 2003年

Vasogenic edema and VEGF expression in a rat two-vein occlusion model

Kimura R., Nakase H., Sakaki T., Taoka T., Tsuji T.

Acta Neurochirurgica, Supplementum ( 86 ) 頁： 213 - 217 2003年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Acta Neurochirurgica, Supplementum

Vasogenic edema plays an important etiologic role in the pathogenesis of cerebral venous circulation disturbances (CVCDs). Since vascular endothelial growth factor (VEGF) is a major mediator in angiogenesis and vascular permeability, including induction of vasogenic edema, the present study was undertaken to investigate whether it has any relevance to CVCDs. Male Wistar rats (n = 15) were used. Two adjacent cortical veins were occluded photochemically using rose bengal dye and fiberoptic illumination, with evaluation 24 hours thereafter by magnetic resonance imaging (MRI). Each brain was removed from the skull immediately after MRI and processed for hematoxylin-eosin staining (H&E staining) of sections for histopathology and comparison with MRI data. VEGF expression as demonstrated immunohistochemically appeared to coincide with vasogenic edema, diagnosed as high intensity areas on apparent diffusion coefficient of water (ADCw) maps. On the basis of these data, we conclude that VEGF is related to formation of vasogenic edema in the acute stage of CVCD. © Springer-Verlag 2003.

DOI： 10.1007/978-3-7091-0651-8_46

Scopus

Vasogenic edema and VEGF expression in a rat two-vein occlusion model 査読有り

R Kimura, H Nakase, T Sakaki, T Taoka, T Tsuji

BRAIN EDEMA XII 86 巻頁： 213 - 217 2003年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：SPRINGER-VERLAG WIEN

Vasogenic edema plays an important etiologic role in the pathogenesis of cerebral venous circulation disturbances (CVCDs). Since vascular endothelial growth factor (VEGF) is a major mediator in angiogenesis and vascular permeability, including induction of vasogenic edema, the present study was undertaken to investigate whether it has any relevance to CVCDs.
Male Wistar rats (n = 15) were used. Two adjacent cortical veins were occluded photochemically using rose bengal dye and fiberoptic illumination, with evaluation 24 hours thereafter by magnetic resonance imaging (MRI). Each brain was removed from the skull Immediately after MRI and processed for hematoxylin-eosin staining (H&E staining) of sections for histopathology and comparison with MRI data. VEGF expression as demonstrated immunohistochemically appeared to coincide with vasogenic edema, diagnosed as high intensity areas on apparent diffusion coefficient of water (ADCw) maps. On the basis of these data, we conclude that VEGF is related to formation of vasogenic edema in the acute stage of CVCD.

DOI： 10.1007/978-3-7091-0651-8_46

Web of Science

[Evaluation of appearance with high-speed CE-3dMRDSA in brain].

Doi T, Nogi A, Taoka T, Hirohashi S

Nihon Hoshasen Gijutsu Gakkai zasshi 58 巻 ( 12 ) 頁： 1615 - 21 2002年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本放射線技術学会

We evaluated the fitting scan technique for CE-3dMRDSA, and found common ground that determines spatial resolution and time resolution (slab thickness and partition number). We also examined the relation between appearance and time resolution (volume of contrast medium and injection speed). To obtain good image contrast, the volume of contrast medium needs to be at least 7 ml and suitable for an injection speed of 3-5 ml/sec. However, when we increased the volume of contrast medium and decreased injection speed, changes in MRDSA images with time became worse. The measure of the bolus with contrast medium was found to determine image contrast. When contrast medium is injected earlier, it circulates earlier within the brain. If the scan time is not short enough, it is not possible to observe changes in MRDSA images. And when spatial resolution is improved, time resolution becomes worse. Therefore, it is important to find the point of compromise between spatial resolution and time resolution. If we look for anterior MIP images, the CNR in the spatial resolusion didn't change, when the slice thickness is more than 3 mm. Because, the partial volume effect decide the image contrast. However, unless the view is from the front, slice thickness influences spatial resolution. Therefore, when we view MIP images from the lateral direction, slice thickness must be set at less than 2 mm. Results indicated that, in CE-3dMRDSA with the fitting technique, slice thickness should be less than 3 mm, partition number 16-20, slab thickness 48 mm, contrast medium volume 7-10 ml, and injection speed 3-5 ml.

DOI： 10.6009/jjrt.kj00000921540

PubMed

CiNii Research

Method and timing of tumor volume measurement for outcome prediction in cervical cancer using magnetic resonance imaging.

Mayr NA, Taoka T, Yuh WT, Denning LM, Zhen WK, Paulino AC, Gaston RC, Sorosky JI, Meeks SL, Walker JL, Mannel RS, Buatti JM

International journal of radiation oncology, biology, physics 52 巻 ( 1 ) 頁： 14-22 2002年1月

Method and timing of tumor volume measurement for outcome prediction in cervical cancer using magnetic resonance Imaging 査読有り

NA Mayr, T Taoka, WTC Yuh, LM Denning, WNK Zhen, AC Paulino, RC Gaston, JI Sorosky, SL Meeks, JL Walker, RS Mannel, JM Buatti

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 52 巻 ( 1 ) 頁： 14 - 22 2002年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

Purpose: Recently, imaging-based tumor volume before, during, and after radiation therapy (RT) has been shown to predict tumor response in cervical cancer. However, the effectiveness of different methods and timing of imaging-based tumor size assessment have not been investigated. The purpose of this study was to compare the predictive value for treatment outcome derived from simple diameter-based ellipsoid tumor volume measurement using orthogonal diameters (with ellipsoid computation) with that derived from more complex contour tracing/region-of-interest (ROI) analysis 3D tumor volumetry.
Methods and Materials: Serial magnetic resonance imaging (MRI) examinations were prospectively performed in 60 patients with advanced cervical cancer (Stages IB2-IVB/recurrent) at the start of RT, during early RT (20-25 Gy), mid-RT (45-50 Gy), and at follow-up (1-2 months after RT completion). ROI-based volumetry was derived by tracing the entire tumor region in each MR slice on the computer work station. For the diameter-based surrogate "ellipsoid volume," the three orthogonal diameters (d(1), d(2), d(3)) were measured on film hard copies to calculate volume as an ellipsoid (d(1) x d(2) x d(3) x pi/6). Serial tumor volumes and regression rates determined by each method were correlated with local control, disease-free and overall survival, and the results were compared between the two measuring methods. Median post-therapy follow-up was 4.9 years (range, 2.0-8.2 years).
Results: The best method and time point of tumor size measurement for the prediction of outcome was the tumor regression rate in the mid-therapy MRI examination (at 45-50 Gy) using 3D ROI volumetry. For the pre-RT measurement both the diameter-based method and ROI volumetry provided similar predictive accuracy, particularly for patients with small (<40 cm(3)) and large ( &GE;100 cm(3)) pre-RT tumor size. However, the pre-RT tumor size measured by either method had much less predictive value for the intermediate-size (40-99 cm(3)) tumors, which accounted for the majority of patients (55%). Tumor regression rate (fast vs. slow) obtained during mid-RT (45-50 Gy), which could only be appreciated by 3D ROI volumetry, had the best outcome prediction rate for local control (84% vs. 22%, p < 0.0001) and disease-free survival (63% vs. 20%, p = 0.0005). Within the difficult to classify intermediate pre-RT size group, slow ROI-based regression rate predicted all treatment failures (local control rate: 0% vs. 91%,p < 0.0001; disease-free survival: 0% vs. 73%, p < 0.0001). Mid-RT regression rate based on simple diameter measurement did not predict outcome. The early-RT and post-RT measurements were least useful with either measuring method.
Conclusion: Our preliminary data suggest that for the prediction of treatment outcome in cervical cancer, initial tumor volume can be estimated by simple diameter-based measurement obtained from film hard copies. When initial tumor volume is in the intermediate size range, ROI volumetry and an additional MRI during RT are needed to quantitatively analyze tumor regression rate for the prediction of treatment outcome. (C) 2002 Elsevier Science Inc.

DOI： 10.1016/S0360-3016(01)01808-9

Web of Science

Anatomical variations of the torcular Herophili evaluated with MR venography

Aiko Fukusumi, T. Tanaka, S. Koh, H. Nakagawa, T. Taoka, K. Takayama, M. Sakamoto, K. Kichikawa, S. Iwasaki

Japanese Journal of Clinical Radiology 47 巻 ( 5 ) 頁： 625 - 631 2002年

Palmaz stent deployment for subclavian and brachiocephalic arterial occlusive disease. Factors predictive of restenosis. Open Access

Nakagawa H, Kichikawa K, Takayama K, Sakamoto M, Wada T, Taoka T, Fukusumi A, Iwasaki S, Uchida H, Sakaki T

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 7 巻 ( Suppl 1 ) 頁： 49 - 52 2001年12月

Detection of early venous filling in gliomas on MRI: Preliminary study by 2D time-resolved dynamic contrast-enhanced MR angiography with echo-sharing technique

Sakamoto M., Taoka T., Iwasaki S., Fukusumi A., Nakagawa H., Hirohashi S., Takayama K., Wada T., Kichikawa K., Uchida H., Ohishi H., Murata K., Okamoto J.

Magnetic Resonance Imaging 19 巻 ( 9 ) 頁： 1193 - 1201 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Magnetic Resonance Imaging

We evaluated the detection of early venous filling of gliomas by 2D time resolved dynamic contrast enhanced MR digital subtraction angiography (MR-DSA) with echo-sharing technique and compared the results with those of conventional contrast digital subtraction angiography (C-DSA). C-DSA and MR-DSA examinations were performed in eight patients with malignant gliomas and compared with regard to the visualization of early filling veins; time intensity curves of arteries, early filling veins and normal veins were made, and rise time and time to peak were evaluated. MR-DSA visualized 12 out of 17 early filling veins depicted on C-DSA. The failure of five veins to be depicted may be due to the overlapping of other structures, such as other vessels and tumor stain. On time intensity curves, the mean difference in rise time was 0.9 sec between the artery and early filling vein, and the mean difference of time to peak was 1.6 sec. C-DSA has been the modality of choice in demonstrating early venous filling, a useful finding in the differential diagnosis of gliomas. However the high temporal resolution of MR-DSA with echo-sharing technique provides sufficient visualization of early venous filling of gliomas. Additional information for precise differential diagnosis may be obtained by adding MR-DSA to the imaging protocol for gliomas. © 2001 Elsevier Science Inc. All rights reserved.

DOI： 10.1016/S0730-725X(01)00450-7

Scopus

Palmaz Stent deployment for subclavian and brachiocephalic arterial occlusive disease - Factors predictive of restenosis 査読有り

H Nakagawa, K Kichikawa, K Takayama, M Sakamoto, T Wada, T Taoka, A Fukusumi, S Iwasaki, H Uchida, T Sakaki

INTERVENTIONAL NEURORADIOLOGY 7 巻頁： 49 - 52 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：EDIZIONI CENTAURO

Palmaz stent deployment is a useful method for subclavian and brachiocephalic arterial occlusive disease. We evaluated restenosis or intimal thickening after Palmaz stent deployment for nine lesions of subclavian or brachiocephalic arterial occlusive disease focusing on stent diameter, atheroma thickness near the stent, and degree of coverage for the lesion. Follow up DSA and IVUS at 5-14 months (mean 9) after therapy showed no significant changes in the size or shape of the stent itself There were two lesions of thin in-stent intimal hyperplasia and five lesions of thick hyperplasia.
There was no close relationship between intimal hyperplasia and stent diameter or atheroma size (relative thickness). There was some relationship between the degree of coverage of the lesion by the stent and degree of intimal hyperplasia, but to determine statistical significance, accumulation of a greater number of cases is necessary.

DOI： 10.1177/15910199010070S106

Web of Science

Detection of early venous filling in gliomas on MRI: preliminary study by 2D time-resolved dynamic contrast-enhanced MR angiography with echo-sharing technique.

Sakamoto M, Taoka T, Iwasaki S, Fukusumi A, Nakagawa H, Hirohashi S, Takayama K, Wada T, Kichikawa K, Uchida H, Ohishi H, Murata K, Okamoto J

Magnetic resonance imaging 19 巻 ( 9 ) 頁： 1193 - 201 2001年11月

Detection of early venous filling in gliomas on MRI: Preliminary Study by 2D time-resolved dynamic contrast-enhanced MR angiography with echo-sharing technique 査読有り

M Sakamoto, T Taoka, S Iwasaki, A Fukusumi, H Nakagawa, S Hirohashi, K Takayama, T Wada, K Kichikawa, H Uchida, H Ohishi, K Murata

MAGNETIC RESONANCE IMAGING 19 巻 ( 9 ) 頁： 1193 - 1201 2001年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

DOI： 10.1016/S0730-725X(01)00450-7

Web of Science

Factors influencing visualization of vertebral metastases on MR imaging versus bone scintigraphy 査読有り

T Taoka, NA Mayr, HJ Lee, WTC Yuh, TM Simonson, K Rezai, KS Berbaum

AMERICAN JOURNAL OF ROENTGENOLOGY 176 巻 ( 6 ) 頁： 1525 - 1530 2001年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ROENTGEN RAY SOC

OBJECTIVE. The purpose of this study was to investigate whether the location and size of vertebral body metastases influence the difference in detection rates between MR imaging and bone scintigraphy.
MATERIALS AND METHODS. We retrospectively evaluated the vertebral body lesions detected on MR imaging in 74 patients with known widely disseminated metastatic disease. Three radiologists independently reviewed the MR images and bone scintigraphs. MR imaging findings included lesion size and its spatial relationship to the bony cortex (intramedullary, subcortical, and transcortical) and results were correlated with those of planar technetium 99m bone scintigraphy.
RESULTS. Findings on bone scans were negative for all intramedullary lesions without cortical involvement shown on MR imaging, regardless of their size. Findings on bone scans (71.3% for transcortical and 33.8% for subcortical) were frequently positive for lesions with cortical involvement (trans- or subcortical), and the probability of positive findings on bone scans was also influenced by the lesion size. Statistical analysis showed a positive correlation among cortical involvement, lesion size, and positive findings on bone scintigraphy (p < 0.0001).
CONCLUSION. Location (the presence of cortical bone involvement on MR imaging) and size of the vertebral body metastases appear to be important contributing factors to the difference in detection rates between MR imaging and bone scintigraphy. Cortical involvement is likely the cause of positive findings on bone scans. Early vertebral metastases tend to be small and located in the medullary cavity without cortical involvement, and therefore, findings may be positive on MR images but negative on bone scans.

DOI： 10.2214/ajr.176.6.1761525

Web of Science

PubMed

Sulcal hyperintensity on fluid-attenuated inversion recovery MR images in patients without apparent cerebrospinal fluid abnormality 査読有り

Taoka, T; Yuh, WTC; White, ML; Quets, JP; Maley, JE; Ueda, T

AMERICAN JOURNAL OF ROENTGENOLOGY 176 巻 ( 2 ) 頁： 519 - 524 2001年2月

Sulcal hyperintensity on fluid-attenuated inversion recovery MR images in patients without apparent cerebrospinal fluid abnormality 査読有り

T Taoka, WTC Yuh, ML White, JP Quets, JE Maley, T Ueda

AMERICAN JOURNAL OF ROENTGENOLOGY 176 巻 ( 2 ) 頁： 519 - 524 2001年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ROENTGEN RAY SOC

OBJECTIVE. Failure to suppress cerebrospinal fluid (CSF) signal intensity (sulcal hyperintensity) on fluid-attenuated inversion recovery (FLAIR) images has been reported in patients with abnormal CSF such as those with meningitis and subarachnoid hemorrhage. Our study investigates the clinical history and MR findings associated with sulcal hyperintensity on FLAIR images in patients without apparent CSF abnormality.
SUBJECTS AND METHODS. Three hundred consecutive MR imaging examinations were prospectively screened for patients with sulcal hyperintensity on FLAIR images. Nine patients with clinical, CT, or laboratory evidence suggesting abnormal CSF were excluded. The distribution of sulcal hyperintensity on FLAIR images and associated abnormal enhance ment were evaluated, The presence of the "dirty CSF" sign (mild increase in CSF signal on unenhanced T1-weighted images or mild decrease on T2-weighted images) in the corresponding hyperintense sulcus was also assessed.
RESULTS. Twenty-six (8.9%) of the 291 patients had sulcal hyperintensity (16 focal. 10 diffuse) associated with 18 masses (6.1%) and eight vascular abnormalities (2.7%). Sulcal hy perintensity was frequently associated with the dirty CSF sign (69.2%) and abnormal contrast enhancement (overall, 96.2%; 88.5%, leptomeningeal; 53.8%, vascular enhancement).
CONCLUSION. Our study shows that sulcal hyperintensity on FLAIR imaging can occur in patients without apparent CSF abnormality. Its frequent association with mass effect, vascular disease, abnormal vascular enhancement, and dirty CSF sign suggests that an increase in blood pool, a small amount of protein leakage, and the "flow-entering" phenomenon of the congested blood may contribute to sulcal hyperintensity on FLAIR images.

DOI： 10.2214/ajr.176.2.1760519

Web of Science

Chronic brain inflammation results in progressive MRI change and dementia in ischemic neurodegeneration 査読有り

Fujioka M, Taoka T, Matsuo Y, Mishima K, Fujiwara M, Ogoshi K, Kondo Y, Sakaki T, Park D, Siesjo B. K

Society for Neuroscience Abstracts 27 巻 ( 2 ) 頁： 2304 2001年

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