研究者詳細 - 田岡　俊昭

Adjunctive techniqueを用いた脳動脈瘤の瘤内塞栓

Tumefactive demyelinating disease(≧30mm)の神経放射線学的およびウイルス学的検討

桐山敬生, 形岡博史, 田岡俊昭, 殿村恭代, 守川公美, 川原誠, 杉江和馬, 降矢芳子, 吉川公彦, 上野聡

臨床神経学 51 巻 ( 12 ) 頁： 1221 - 1221 2011年12月

中川裕之, 宮坂俊輝, 明珍薫, 和田敬, 坂本雅彦, 高山勝年, 田岡俊昭, 吉川公彦, 中川一郎, 内山佳知

JNET: Journal of Neuroendovascular Therapy 5 巻 ( 4 ) 頁： 253 - 253 2011年11月

FilterWire EZを用いた頸動脈ステント留置術初期治療成績

和田敬, 高山勝年, 中川裕之, 宮坂俊輝, 明珍薫, 坂本雅彦, 田岡俊昭, 中川一郎, 黒川紳一郎, 中瀬裕之, 吉川公彦

JNET: Journal of Neuroendovascular Therapy 5 巻 ( 4 ) 頁： 257 - 257 2011年11月

頭蓋内静脈逆流を伴う硬膜動静脈瘻におけるSusceptibility Weighted Imagingの有用性

中川一郎, 和田敬, 中川裕之, 弘中康雄, 本山靖, 朴永銖, 田岡俊昭, 吉川公彦, 中瀬裕之

JNET: Journal of Neuroendovascular Therapy 5 巻 ( 4 ) 頁： 270 - 270 2011年11月

Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study. Open Access

Kitamura S, Morikawa M, Kiuchi K, Taoka T, Fukusumi M, Kichikawa K, Kishimoto T

BMC research notes 4 巻 ( 1 ) 頁： 378 2011年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Research Notes

Background: Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles. Methods. 40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles. Results: We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus. Conclusion: In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies. © 2010 Kitamura et al; licensee BioMed Central Ltd.

DOI： 10.1186/1756-0500-4-378

Open Access

Usefulness of Contrast-Enhanced Magnetic Resonance Angiography for Follow-Up of Coil Embolization With the Enterprise Stent for Cerebral Aneurysms 査読有り

その他リンク： http://orcid.org/0000-0001-9227-0240

二相性の経過を示した傍腫瘍性脳幹脳炎のMRI画像とRamussen脳炎のベンゾジアゼピン受容体脳画像

形岡博史, 桐山敬生, 小林恭代, 泉哲石, 真貝隆之, 田岡俊昭, 上野聡

NEUROINFECTION 16 巻 ( 2 ) 頁： 158 - 158 2011年10月

MRIでの信号解釈の基礎

田岡俊昭

CI研究 : progress in computed imaging 33 巻 ( 2 ) 頁： 77 - 82 2011年9月

Takayama, K; Taoka, T; Nakagawa, H; Myouchin, K; Wada, T; Sakamoto, M; Fukusumi, A; Iwasaki, S; Kurokawa, S; Kichikawa, K

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 35 巻 ( 5 ) 頁： 568 - 572 2011年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Computer Assisted Tomography

Objective: The aim of this study was to determine the feasibility and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) and 3-dimensional (3D) time-of-flight (TOF) MRA for follow-up of intracranial aneurysms treated using the Enterprise stent. Methods: Five aneurysm cases using the Enterprise stent were prospectively analyzed and were followed up with CE-MRA, 3D TOF MRA, and digital subtraction angiography (DSA). Depictions of parent artery lumen and the aneurysm neck with 3D TOF MRA and CE-MRA were compared with those of DSA. Results: In all cases, on 3D TOF MRA, it was difficult to evaluate the parent artery lumen and aneurysm neck owing to the significant artifacts from the stent. Contrast-enhanced MRA sufficiently demonstrated parent artery lumen and aneurysm neck distinctly and as clear as DSA did in all cases. Conclusions: For follow-up after coiling with an Enterprise stent, CE-MRA may be necessary to avoid susceptibility artifacts caused by the stent. Copyright © 2011 by Lippincott Williams & Wilkins.

DOI： 10.1097/RCT.0b013e31822bd498

White matter changes in dementia with Lewy bodies and Alzheimer's disease: a tractography-based study.

Kiuchi K, Morikawa M, Taoka T, Kitamura S, Nagashima T, Makinodan M, Nakagawa K, Fukusumi M, Ikeshita K, Inoue M, Kichikawa K, Kishimoto T

Journal of psychiatric research 45 巻 ( 8 ) 頁： 1095 - 100 2011年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Psychiatric Research

Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are different types of dementia. However, their clinical symptoms partially overlap and differential diagnosis is occasionally difficult. There is need for additional diagnostic criteria to reliably differentiate between these two conditions. Meanwhile, several imaging studies have showed inconsistent results between DLB and AD. The aim of this study was to use a tractography-based analysis to elucidate white matter alterations in subjects with DLB compared to those with AD and to controls. An understanding of the white matter connectivity differences between AD, DLB and controls will be helpful for differential diagnosis and an understanding of the pathophysiology. Twenty-six subjects with DLB, 26 with AD and 26 controls underwent magnetic resonance diffusion tensor imaging and neuropsychological assessment. Diffusion tensors were computed and fiber-tract maps were created using "dTV II" software. We measured mean fractional anisotropy (FA) values along the uncinate fasciculus (UNC), the inferior occipitofrontal fasciculus (IOFF) and the inferior longitudinal fasciculus (ILF). Both subjects with DLB and AD had lower FA values for the bilateral UNC than controls. Subjects with DLB exhibited significantly lower FA values on both sides of the IOFF and the left side of the ILF than those of controls. Although there were no significant differences between subjects with DLB and AD for any measurements, those with DLB exhibited lower FA values especially in visual-related white matter. These different changes in white matter tracts among groups could be helpful for differential diagnosis and an understanding of the pathophysiology. © 2011 Elsevier Ltd.

DOI： 10.1016/j.jpsychires.2011.01.011

Prediction of periprocedual ischemic complication in carotid artery stenting with filter embolic protection device by using magnetic resonance (MR) plaque imaging 査読有り

Kichikawa, K; Takayama, K; Nakagawa, H; Miyouchinn, K; Taoka, T; Sakamoto, M; Wada, T; Kurokawa, S

JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 巻頁： 497 - 498 2011年7月

Transient hyperintensity in the subthalamic nucleus and globus pallidus of newborns on T1-weighted images. Open Access

Taoka T, Aida N, Ochi T, Takahashi Y, Akashi T, Miyasaka T, Iwamura A, Sakamoto M, Kichikawa K

AJNR. American journal of neuroradiology 32 巻 ( 6 ) 頁： 1130 - 7 2011年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Neuroradiology

BACKGROUND AND PURPOSE: In the brains of newborns, changes in signal intensity in most structures can be explained by the development of myelination. However, there are some structures for which signal intensity changes cannot be accounted for by myelination alone. We examined the STN and globus pallidus signal intensities and tried to determine whether a relationship exists between the signal intensity and the postnatal age or the gestational age at the examination. MATERIALS AND METHODS: We examined T1WI and T2WI obtained from 79 neonates who showed normal development at their 2-year follow-up examinations. We performed both qualitative and quantitative (signal intensity ratio to the thalamus) evaluation of the STN and globus pallidus signals, and we examined the correlation between signal intensity changes and the age of neonates. RESULTS: With increasing postnatal age at examination, the high signal intensity on the T1WI for both STN and globus pallidus diminished. Although the disappearance of this hyperintensity was well correlated with the postnatal age at examination for both the qualitative and quantitative studies, there was no correlation with gestational age at examination. For the T2WI, there was no correlation with either the postnatal age or the gestational age at examination. CONCLUSIONS: Signal intensity on T1WI in the STN and globus pallidus is not related to the gestational age at examination; instead, signal intensities on T1WI seem to be more dependent upon the postnatal age at examination.

DOI： 10.3174/ajnr.A2451

Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm. Open Access

Kiriyama T, Kataoka H, Taoka T, Tonomura Y, Terashima M, Morikawa M, Tanizawa E, Kawahara M, Furiya Y, Sugie K, Kichikawa K, Ueno S

Journal of neuroimaging : official journal of the American Society of Neuroimaging 21 巻 ( 2 ) 頁： e69 - 77 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuroimaging

BACKGROUND AND PURPOSE: Features of tumefactive demyelinating lesion (TDL) on magnetic resonance imaging (MRI) can facilitate the differential diagnosis of TDL and neoplastic lesions, but vary considerably among patients. The larger TDL grows, the more difficult it becomes to differentiate TDL from neoplastic lesions. The purpose of this study was to elucidate typical MRI features in 12 patients with large TDL (>30 mm in diameter). METHODS: We identified 12 patients with large TDL (six men, six women; age range 17-64 years, median age 27 years) and studied the clinical histories and the results of laboratory and various radiological studies in these patients. All cases of clinically definite multiple sclerosis were diagnosed in accordance with McDonald's revised criteria. RESULTS: Common MRI features of large TDLs included variable degrees of mass effect (71%) and edema (100%), a T2 hypointense rim (79%), venular enhancement (57%), and peripheral restriction on diffusion-weighted images (50%). Ring enhancement (38%), open-ring enhancement (31%), or decreased N-acetylaspartate ratios on magnetic resonance spectroscopy (22%) were less frequently observed. Brain angiography demonstrated venous dilatations on and around the TDL. CONCLUSIONS: The diagnosis of large TDL is challenging. Our findings suggest that multiple venous dilatations on and around TDLs on angiography can facilitate diagnosis. © 2010 by the American Society of Neuroimaging.

DOI： 10.1111/j.1552-6569.2010.00502.x

Initial experience of carotid artery stenting using the Carotid WALLSTENT and FilterWire EZ in Japan

Takayama, K; Taoka, T; Nakagawa, H; Myouchin, K; Wada, T; Miyasaka, T; Sakamoto, M; Fukusumi, A; Iwasaki, S; Kimura, R; Kurokawa, S; Kichikawa, K

JAPANESE JOURNAL OF RADIOLOGY 29 巻 ( 1 ) 頁： 51 - 58 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Radiology

Purpose: The Carotid WALLSTENT (CWS) and Filter-Wire EZ (FWEZ) embolic protection devices for use in carotid arterial stenting (CAS) were newly approved for national health insurance coverage in Japan in April 2010. This article describes our initial experience of CAS using the CWS and FWEZ. Material and methods: A group of 14 patients (12 men, 2 women; mean age 70.1 years, range 59-83 years) with 15 carotid artery stenoses at high risk for carotid endarterectomy were treated by CAS using the CWS and FWEZ. Of these stenoses, 5 were symptomatic with ≥50% stenosis of the common or internal carotid artery (ICA), and 10 were asymptomatic with ≥80% stenosis. The rates of technical success, ICA flow impairment during filter protection, periprocedural ischemic stroke, 30-day major adverse events (MAEs) (stroke, death, myocardial infarction), and development of new ischemic lesions on diffusion-weighted imaging (DWI) were assessed. Results: CAS was successful in all cases. There was no ICA flow impairment, periprocedural ischemic stroke, or MAEs. DWI showed new ipsilateral ischemic lesions in only one patient (6.7%). Conclusion: Our initial clinical experience using the CWS and FEWZ for CAS was generally excellent, and the incidence of postprocedural ischemic lesions was low. © 2011 Japan Radiological Society.

DOI： 10.1007/s11604-010-0518-x

Serial neuroimaging in tolosa-hunt syndrome with acute bilateral complete ophthalmoplegia.

Sugie K., Morikawa M., Taoka T., Hirano M., Ueno S.

Journal of neuroimaging : official journal of the American Society of Neuroimaging 21 巻 ( 1 ) 頁： 79 - 82 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of neuroimaging : official journal of the American Society of Neuroimaging

Tolosa-Hunt syndrome (THS) is a very rare, relapsing, and remitting painful ophthalmoplegia caused by nonspecific granulomatous inflammation in the cavernous sinus. To our knowledge, bilateral complete, simultaneous palsies of all 3 cranial nerves associated with extraocular movement have not been reported. We describe the first such patient with bilateral THS that responded quickly to corticosteroid therapy. A 54-year-old man presented with a periorbital and frontal headache with acute bilateral severe blepharoptosis and fixed eyes, which dramatically responded to corticosteroid therapy. He had diabetes mellitus type II. Brain MRI showed granulomatous inflammation in both cavernous sinuses and thickening of the surrounding dura mater of the cranial base, suggesting the coexistence of focal hypertrophic cranial pachymeningitis. Our experience indicates that steroid therapy with strict control of blood sugar should be considered in patients with THS complicated by diabetes. MRI is a valuable tool for serially monitoring the response of lesions to treatment in THS.

DOI： 10.1111/j.1552-6569.2009.00381.x

Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with a History of Brain Irradiation 査読有り国際誌 Open Access

Kasahara, S; Miki, Y; Kanagaki, M; Yamamoto, A; Mori, N; Sawada, T; Taoka, T; Okada, T; Togashi, K

RADIOLOGY 258 巻 ( 1 ) 頁： 222 - 228 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Radiology

Purpose: To assess the frequency of hyperintensity in the dentate nucleus on T1-weighted magnetic resonance (MR) images and to establish correlations between such hyperintensity and clinical factors, including a history of brain irradiation. Materials and Methods: This study was approved by the institutional review board, and each patient provided written informed consent. Three hundred sixty-two patients (164 men, 198 women; mean age, 62 years) were evaluated. Unenhanced T1-weighted MR images were obtained by using a spin-echo sequence at 3.0 T. Two neuroradiologists, who were blinded to clinical data, independently evaluated the signal intensity of the dentate nucleus compared with the signal intensity of the central white matter of the cerebellum by using a four-point graded response scale (grade 4 indicated prominent hyperintensity; grade 3, faint hyperintensity; grade 2, isointensity; and grade 1, hypointensity). Backward stepwise regression analysis was used to evaluate the relationship between signal intensity grades and the following clinical factors: sex, age, the interaction between age and sex, hypertension, dyslipidemia, diabetes mellitus, liver dysfunction, brain infarction, brain tumor, spinocerebellar degeneration, multiple sclerosis, a history of chemotherapy, and a history of brain irradiation. Results: T1-hyperintense dentate nuclei were present in 41 (11%) of the 362 patients. Of these 41 patients, 31 (76%) had a history of brain irradiation. Signal intensity grade of the dentate nucleus on T1-weighted MR images correlated significantly with a history of brain irradiation (P <.001) but no other clinical factor. Conclusion: A hyperintense dentate nucleus may be seen on unenhanced T1-weighted MR images in some patients and may be associated with a history of brain irradiation. © RSNA, 2010.

DOI： 10.1148/radiol.10100508