研究者詳細 - 田岡　俊昭

O2-47 てんかん外科における視放線テンソル画像の有用性と問題点(画像3,一般演題(口演),てんかん制圧:新たなステージに向けて,第41回日本てんかん学会)

アルツハイマー病での側頭葉幹のテンソル解析

田岡俊昭, 森川将行, 坂本雅彦, 中川裕之, 岩崎聖, 明石敏昭, 宮坂俊輝, 高山勝年, 木内邦明, 岸本年史, 吉川公彦

認知神経科学 10 巻 ( 1 ) 頁： 39 - 42 2008年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：認知神経科学会

【要旨】拡散テンソル法は生体内の水の拡散の程度や、異方性を解析できる手法である。一般に白質神経路の障害では、拡散能が上昇し、拡散異方性が低下する傾向にある。拡散テンソル法による拡散能・拡散異方性の検討は、拡散テンソルトラクトグラフィーと組合せることにより、解剖学的により特異的な情報を得ることができると考えられる。Alzheimer病をはじめとした神経変性疾患の評価に、本手法が有用であることが示唆される。

DOI： 10.11253/ninchishinkeikagaku1999.10.39

中瀬裕之, 田村健太郎, 金永進, 平林秀裕, 榊寿右, 星田徹, 田岡俊昭

てんかん研究 25 巻 ( 3 ) 頁： 310 2007年9月

A case of infantile Alexander disease diagnosed by magnetic resonance imaging and genetic analysis

SAKAKIBARA Takafumi, TAKAHASHI Yukihiro, FUKUDA Kazuyoshi, INOUE Tomomi, KUROSAWA Tomoko, NISHIKUBO Toshiya, SHIMA Midori, TAOKA Toshiaki, AIDA Noriko, TSUJINO Seiichi, KANAZAWA Naomi, YOSHIOKA Akira

29 巻 ( 8 ) 頁： 525 - 528 2007年9月

A case of infantile Alexander disease diagnosed by magnetic resonance imaging and genetic analysis.

Sakakibara T, Takahashi Y, Fukuda K, Inoue T, Kurosawa T, Nishikubo T, Shima M, Taoka T, Aida N, Tsujino S, Kanazawa N, Yoshioka A

Brain & development 29 巻 ( 8 ) 頁： 525 - 8 2007年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Brain and Development

We encountered a male infant with infantile Alexander disease presenting with megalencephaly and hydrocephalus as a neonate and subtle seizures at 3 months of age. At 6 months of age, bulbar paralysis appeared. Brain magnetic resonance imaging (MRI) showed abnormal findings with white matter involvement and a characteristic periventricular rim, satisfying the diagnostic criteria proposed by van der Knaap, except for MRI contrast. R239H mutation of glial fibrillary acidic protein gene was identified, representing a common cause of infantile-type Alexander disease. © 2007 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.braindev.2007.02.002

Diffusivity and diffusion anisotropy of cerebellar peduncles in cases of spinocerebellar degenerative disease. 国際誌

Taoka T, Kin T, Nakagawa H, Hirano M, Sakamoto M, Wada T, Takayama K, Wuttikul C, Iwasaki S, Ueno S, Kichikawa K

NeuroImage 37 巻 ( 2 ) 頁： 387 - 93 2007年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NeuroImage

Purpose: This study accessed the feasibility of using tractography-based analysis to evaluate the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of three cerebellar peduncles in subtypes of spinocerebellar degenerative disease. Materials and methods: We examined 7 cases of dentatorubro-pallidoluysian atrophy (DRPLA), 4 cases of multiple system atrophy, cerebellar type (MSA-C), 4 cases of late cerebellar cortical atrophy (LCCA) and 8 controls. Diffusion tensor images were obtained, and tractographies of cerebellar peduncles were generated. ADC and FA along the cerebellar peduncles and volume of cerebellar peduncle were measured, and analyses of variance were made among the control and each spinocerebellar degenerative disease groups. Results: There were statistically significant decrease in FA and volume and increase in ADC values between DRPLA cases and controls in all three cerebellar peduncles. On the other hand, MSA-C cases mainly showed statistically significant decreased FA and volume and increased ADC values in the middle cerebellar peduncle. LCCA cases did not show prominent difference in the three cerebellar peduncles. Conclusion: The values of diffusivity and diffusion anisotropy of cerebellar peduncles evaluated by tractography based measurements seem to reflect characteristics of the different types of spinocerebellar degenerative diseases. Tractography-based measurements may be a feasible tool for differential diagnosis of spinocerebellar degenerative disease. © 2007 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.neuroimage.2007.05.028

Cerebral hemorrhage with angiographic extravasation immediately after carotid artery stenting

Takayama K., Nakagawa H., Iwasaki S., Taoka T., Wada T., Myouchin K., Sakamoto M., Fukusumi A., Kichikawa K.

Radiation Medicine - Medical Imaging and Radiation Oncology 25 巻 ( 7 ) 頁： 359 - 363 2007年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Radiation Medicine - Medical Imaging and Radiation Oncology

Recognizing cerebral hyperperfusion syndrome with intracerebral hemorrhage following carotid artery stenting is critical because the mortality rate is high. This type of hemorrhage usually arises from within several hours to a few days after the procedure. Here we describe a putaminal hemorrhage with extravasation during angiography that developed immediately after carotid artery stenting. A search of the literature revealed only one other similar case report. The etiology of the intracerebral hemorrhage immediately after carotid stenting might be analogous to that of hypertensive hemorrhage. © 2007 Japan Radiological Society.

DOI： 10.1007/s11604-007-0147-1

正期産児の頭蓋内出血 ; 表在性脳実質および脳軟髄膜出血の2例

Parasagittal Arachnoid Markings on the Inner Skull on Three-Dimensional CT: Relation between Hydrocephalus and Arachnoid Granules.

Taoka T, Ida Y, Nakagawa H, Iwasaki S, Sakamoto M, Fukusumi A, Takayama K, Wada T, Myochin K, Wuttikul C, Kichikawa K

The neuroradiology journal 20 巻 ( 3 ) 頁： 259 - 64 2007年6月

高橋幸博, 山田佳世, 新居育世, 田岡俊昭, 釜本智之, 井上知美, 新川友子, 矢田弘史, 西久保敏也, 内田優美子, 箕輪秀樹, 安原肇, 坂東由香, 川口千晴, 扇谷綾子, 藤本京利, 朴永銖, 吉岡章

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 17 巻 ( 1 ) 頁： "S - 29"-"S-30" 2007年6月

Successful percutaneous transluminal angioplasty and stenting for symptomatic intracranial vertebral artery stenosis using intravascular ultrasound virtual histology 査読有り

Takayama K., Taoka T., Nakagawa H., Myouchin K., Wada T., Sakamoto M., Fukusumi A., Iwasaki S., Kurokawa S., Kichikawa K.

Radiation Medicine - Medical Imaging and Radiation Oncology 25 巻 ( 5 ) 頁： 243 - 246 2007年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Radiation Medicine - Medical Imaging and Radiation Oncology

This is the first report of percutaneous transluminal angioplasty (PTA) of an intracranial artery applying intravascular ultrasound virtual histology (IVUS-VH), which has been recently developed for tissue characterization of coronary artery plaque. We report a case of successful PTA and stenting for symptomatic intracranial vertebral artery stenosis using IVUS-VH. © 2007 Japan Radiological Society.

DOI： 10.1007/s11604-007-0127-5

Parasagittal arachnoid markings on the inner skull on three-dimensional CT: Relation between hydrocephalus and arachnoid granules

Taoka T., Ida Y., Nakagawa H., Iwasaki S., Sakamoto M., Fukusumi A., Takayama K., Wada T., Myochin K., Wuttikul C., Kichikawa K.

Neuroradiology Journal 20 巻 ( 3 ) 頁： 259 - 264 2007年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroradiology Journal

The purpose of the study was to evaluate the number and size of arachnoid markings on the inner plate of the skull on 3D-CT. The subjects included 16 hydrocephalus and 26 non-hydrocephalus cases. We evaluated the correlation between age and both the number and sizes of the arachnoid markings, and compared them between hydrocephalus and non-hydrocephalus cases. We also evaluated cases exhibiting a "smooth cranium" that had no arachnoid markings at all on the inner plate. There was a positive correlation between age and the number of the arachnoid markings. There were no statistically significant differences in arachnoid markings between hydrocephalus and non-hydrocephalus cases, while, there were statistically significant differences in the frequency of "smooth cranium" findings in the population under ten years old. The "smooth cranium" can only be seen in hydrocephalus cases. These findings may be a clue to the morphological or functional changes of the arachnoid villi in hydrocephalus cases.

DOI： 10.1177/197140090702000301

Physiologic and pathologic statuses that show reduced relaxation time within the brain

Taoka T., Nakagawa H., Kichikawa K.

Japanese Journal of Clinical Radiology 52 巻 ( 4 ) 頁： 555 - 566 2007年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Clinical Radiology

Pathologic tissue within the brain usually shows elongated relaxation time reflecting large water content, and result in low signals on T1 weighted images and high signals on T2 weighted images. However, there are some statuses that show reduced relaxation times. In this article, we show the mechanism of the reduce in relaxation times and we review the physiologic and pathologic status that shows high signals on T1 weighted images and low signals on T2 weighted images.

Treatable fluctuating Parkinsonism and dementia in a patient with a dural arteriovenous fistula [5] 国際誌

拡散テンソルtractographyを用いたアルツハイマー病患者における後部帯状束の検討査読有り

木内邦明, 森川将行, 田岡俊昭, 松田康裕, 長内清行, 山内崇平, 牧之段学, 則本和伸, 芳野浩樹, 井上雄一朗, 井上眞, 中川康司, 吉川公彦, 岸本年史

精神神経学雑誌 ( 2007特別 ) 頁： S161 - S161 2007年5月

Kajitani M., Yagura H., Kawahara M., Hirano M., Ueno S., Fujimoto K., Sakaki T., Taoka T., Nakagawa H., Kichikawa K.

Movement Disorders 22 巻 ( 3 ) 頁： 437 - 439 2007年2月

Extensive neuroimaging of a transient lesion in the splenium of the corpus callosum [7]

Shimizu H., Kataoka H., Yagura H., Hirano M., Taoka T., Ueno S.

European Journal of Neurology 14 巻 ( 1 ) 頁： E37 - E39 2007年1月

Parasagittal arachnoid markings on the inner skull on three-dimensional CT: Relation between hydrocephalus and arachnoid granules 査読有り

Toshiaki Taoka, Y. Ida, H. Nakagawa, S. Iwasaki, M. Sakamoto, A. Fukusumi, K. Takayama, T. Wada, K. Myochin, C. Wuttikul, K. Kichikawa

Neuroradiology Journal 20 巻 ( 3 ) 頁： 259 - 264 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Centauro SRL

DOI： 10.1177/197140090702000301

Displacement of the facial nerve course by vestibular schwannoma: preoperative visualization using diffusion tensor tractography. 国際誌

その他リンク： http://orcid.org/0000-0001-9227-0240

Taoka T, Hirabayashi H, Nakagawa H, Sakamoto M, Myochin K, Hirohashi S, Iwasaki S, Sakaki T, Kichikawa K

Journal of magnetic resonance imaging : JMRI 24 巻 ( 5 ) 頁： 1005 - 10 2006年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Magnetic Resonance Imaging

Purpose: To preoperatively visualize the course of the facial nerve, which Is displaced by vestibular schwannoma, using diffusion tensor (DT) tractography, and to evaluate the agreement with surgical findings. Materials and Methods: The subjects were eight patients with vestibular schwannoma who had undergone removal surgery. DT MR images were obtained and tracts that were considered to represent the facial nerve were constructed. We assessed the success rate for tract construction and evaluated the agreement between tractography findings and surgery. Results: We obtained a tract that connected the internal auditory meatus and brainstem, and was considered to represent the facial nerve in seven of eight cases. The course of the constructed tract agreed with surgical findings in five of these seven cases. One exception was a case in which the tumor was too large to enable intraoperative observation of the facial nerve; however, the facial nerve appeared to be displaced anteriorly at intracapsular resection, in agreement with tractography. In the other case, the schwannoma was mostly cystic. Conclusion: Tractographs constructed using MR tensor images enabled us to identify tracts considered to represent facial nerves. We consider DT tractography to be a useful tool for preoperatively predicting facial nerve displacement in vestibular schwannoma. © 2006 Wiley-Liss, Inc.

DOI： 10.1002/jmri.20725

Global and region-specific analyses of apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy.

Kin T, Hirano M, Taoka T, Furiya Y, Kataoka H, Kichikawa K, Ueno S

AJNR. American journal of neuroradiology 27 巻 ( 7 ) 頁： 1463 - 6 2006年8月

Global and region-specific analyses of apparent diffusion coefficient in dentatorubral-pallidoluysian atrophy 査読有り

T. Kin, M. Hirano, T. Taoka, Y. Furiya, H. Kataoka, K. Kichikawa, S. Ueno

AMERICAN JOURNAL OF NEURORADIOLOGY 27 巻 ( 7 ) 頁： 1463 - 1466 2006年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER SOC NEURORADIOLOGY

BACKGROUND AND PURPOSE: Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar ataxia. Techniques for the quantitative assessment of neurodegenerative lesions remain to be established in this disease. We attempted to quantify global and region-specific neuro. degeneration in DRPLA using analysis of apparent diffusion coefficient (ADC) maps.
METHODS: Diffusion-weighted images (b = 1000 s/mm(2)) by echo-planar sequences were obtained with the use of a 1.5T clinical scanner. Whole-brain histogram and region of interest (ROI) analyses of ADC values as well as conventional MR imaging studies were performed in 6 patients with genetically confirmed DRPLA.
RESULTS: Histograms demonstrated significantly higher mean ADC values in the patients than in age- and sex-matched control subjects (P <.01). 1901 analysis revealed that the patients had significantly higher ADC values in the cerebellum and globus pallidus, preferentially affected regions (P <.05), but not in the thalamus, the region relatively spared in this disease. ADC values in the white matter were higher only in patients with adult-onset disease. Histogram analyses could more sensitively identify abnormalities than ROI analyses, because the former avoided errors associated with setting ROIs and thus had smaller P values on statistical analysis than the latter.
CONCLUSIONS: Histogram ADC analyses were more sensitive for the detection of neurodegeneration in DRPLA than ROI analyses, whereas ROI analyses revealed regional alterations reflecting the distribution of pathologic changes. Thus, histogram and ROI analyses complement each other and may permit the sensitive, quantitative evaluation of neurodegeneration in DRPLA, especially that involving the globus pallidus showing normal T2 signals.