研究者詳細 - 田岡　俊昭

その他リンク： http://orcid.org/0000-0001-9227-0240

Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model 査読有り国際誌

Taoka, T; Fujioka, M; Kashiwagi, Y; Obata, A; Rokugawa, T; Hori, M; Masutani, Y; Aoki, S; Naganawa, S; Abe, K

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 25 巻 ( 3 ) 頁： 610 - 617 2016年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Stroke and Cerebrovascular Diseases

Objective To evaluate the relationship between fiber bundle direction and changes in diffusion kurtosis, we evaluated the apparent diffusion kurtosis coefficients (AKCs) that were perpendicular to and parallel to the principal diffusion tensor eigenvector. Materials and Methods Adult male Wistar rats were subjected to 30 or 60 minutes of middle cerebral artery occlusion and imaged with a 7T Magnetic Resonance Imager System (Varian MRI System 7T/210: Agilent Technologies, CA). Diffusion kurtosis images were obtained before middle cerebral artery (MCA) reperfusion and 3, 6, and 24 hours after reperfusion to generate the apparent diffusion coefficient (ADC), fractional anisotropy (FA), mean apparent diffusion kurtosis coefficient (mAKC), AKC axial to the eigenvector (axAKC), and AKC radial to the eigenvector (radAKC) images. The time course of the region/normal ratio was evaluated for the above parameters in the caudoputamen and white matter. Results Relative FA and relative ADC values decreased 3 hours after MCA reperfusion and remained decreased until 24 hours. Relative mAKC, axAKC, and radAKC values were increased 3 hours after MCA reperfusion, peaked after 6 hours, and slightly decreased after 24 hours. In the white matter, axAKC showed larger changes than radAKC. Conclusion The time course of the diffusion kurtosis value showed earlier pseudonormalization than the ADC value of the lesions. For white matter lesions, the increase in axAKC was larger than that in radAKC, suggesting that the tissue changes after infarction mainly produce reduced diffusivity along the fibers and lead to increased inhomogeneity of the diffusion.

DOI： 10.1016/j.jstrokecerebrovasdis.2015.11.028

その他リンク： http://orcid.org/0000-0001-9227-0240

Heavily T<sub>2</sub>-Weighted 3D-FLAIR Improves the Detection of Cochlear Lymph Fluid Signal Abnormalities in Patients with Sudden Sensorineural Hearing Loss 査読有り Open Access

Naganawa, S; Kawai, H; Taoka, T; Suzuki, K; Iwano, S; Satake, H; Sone, M; Ikeda, M

MAGNETIC RESONANCE IN MEDICAL SCIENCES 15 巻 ( 2 ) 頁： 203 - 211 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society for Magnetic Resonance in Medicine

PURPOSE: To compare the signal increase in cochlear lymph fluid on three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) in patients with sudden sensorineural hearing loss (SNHL) between regular contrast 3D-FLAIR (FL) and heavily T2-weighted 3D-FLAIR (HF). METHODS: Twenty-five patients with unilateral sudden SNHL and eight healthy volunteers were included. Patients were divided into two groups: the mild group consisted of 9 patients, with an average hearing level of 60 dB or less; the severe group consisted of 16 patients, with an average hearing level of more than 60 dB. All patients and healthy volunteers underwent magnetic resonance (MR) cisternography for anatomical reference of the fluid space with FL and HF at 3 T. The region of interest (ROI) was manually drawn on the mid-modiolar section of the MR cisternography around the cochlea. The ROI for noise was drawn within the air space. ROIs were copied onto the FL and HF images. The contrast-to-noise ratio (CNR) between the affected and non-affected ear was measured in the patient group and the CNR between the right and left ear was also measured in the control group. Differences in the CNR on FL and HF images among t

DOI： 10.2463/mrms.mp.2015-0065

Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide 査読有り Open Access

Naganawa, S; Kawai, H; Taoka, T; Suzuki, K; Iwano, S; Satake, H; Sone, M; Ikeda, M

MAGNETIC RESONANCE IN MEDICAL SCIENCES 15 巻 ( 3 ) 頁： 308 - 315 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Magnetic Resonance in Medical Sciences

PURPOSE: Increased cochlear lymph fluid signals on three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) images obtained several minutes after intravenous administration of a single dose of gadolinium-based contrast agent (IV-SD-GBCA) in a patient with severe retrofenestral type otosclerosis had been reported. This increase was thought to represent breakdown of the blood-labyrinthine barrier. The purpose of this study was to evaluate cochlear lymph signal on heavily T2-weighted 3D-FLAIR (HF) images obtained 4 hours after IV-SD-GBCA in patients with otosclerosis, Meniere's disease, and healthy subjects. MATERIALS AND METHODS: Twenty-two ears from 12 patients with otosclerotic plaques determined by computed tomography (CT), 16 ears from 8 healthy volunteers, and 10 ears from 9 Meniere's disease patients with significant endolymphatic hydrops on magnetic resonance (MR) images were retrospectively analyzed. Images were obtained 4 hours after IV-SD-GBCA. Patients and healthy volunteers underwent MR cisternography (MRC) for anatomical reference of the fluid space and HF at 3T. The region of interest (ROI) was manually drawn on MRC images around the scala tympani in the basal c

DOI： 10.2463/mrms.mp.2015-0121

Progress in magnetic resonance diffusion image 査読有り

Taoka T.

Japanese Journal of Neurosurgery 25 巻 ( 5 ) 頁： 402 - 410 2016年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Neurosurgery

Diffusion of water is based on the principle that water molecules show random motion. In diffusion studies on magnetic resonance imaging using a motion proving gradient, a signal decrease which is caused by molecular diffusion in the tissue provides information about tissue structure and physiological status. Diffusion-weighted images play a very important role in brain related diagnosis, especially for acute infarctions, and have become an essential tool in clinical practice. Diffusion tensor imaging using the Gaussian distribution model also has made strides in evaluating anisotropic water diffusion in the white matter in which water diffusion is restricted by macromolecules, membrane, and myelin. Diffusion tensor imaging is based on a mathematical model of an ellipsoid. Thus principal directions of diffusion and the magnitude of diffusion along those directions can be calculated. Diffusion tensor tractography is an innovative application of the diffusion tensor method which can access the pathways of neuronal fibers. However, neuronal tissue is a highly heterogeneous structure on various scales and the Gaussian distribution has only been adapted for free diffusion in a fluid that is uniform and sufficiently large. Complicated wall structures exist in the neuronal tissue, and the Gaussian distribution model does not reflect the existence of a large number of compartments and nerve tracts, particularly in the central nervous system. Therefore, instead of a simple Gaussian distribution model, measurement of the probability distribution of a detailed water molecule is necessary. One method is q-space imaging (QSI). QSI is performed by measuring a large amount of diffusion encoding and can provide the probability density function of individual water molecules. Although QSI is theoretically superior to conventional Gaussian distribution analysis, one limitation of QSI is the long acquisition time due to the large sampling number. The concept of kurtosis is another method to evaluate non-Gaussianity. Kurtosis is a quantity that reflects a gap between the diffusion distribution of a water molecule in vivo and the Gaussian distribution, and can be calculated from datasets of relatively few diffusion encoding elements compared to QSI. Thus, a rather short acquisition time is required for kurtosis. Recently, other innovative applications of non-Gaussian diffusion have been introduced including neurite orientation dispersion and density imaging (NODDI) which is a model-based diffusion technique that allows for the quantification of specific microstructural features directly related to neuronal morphology. These novel techniques will provide useful information on tissue microstructure not only in the scientific research but also in the clinical practice.

DOI： 10.7887/jcns.25.402

CiNii Research

Enterprise Stent-assisted Cerebral Aneurysm Coiling: Can Antiplatelet Therapy be Terminated after Neointima Formation with the Enterprise Stent? 査読有り Open Access

Katsutoshi Takayama, Toshiaki Taoka, Kaoru Myouchin, Takeshi Wada, Hiroyuki Nakagawa, Ichiro Nakagawa, Toshiteru Miyasaka, Masahiko Sakamoto, Shinichiro Kurokawa, Kimihiko Kichikawa

Journal of Neuroendovascular Therapy 10 巻 ( 4 ) 頁： 201 - 205 2016年

Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model 査読有り

Taoka T, Fujioka M, Kashiwagi Y, Obata A, Rokugawa T, Hori M, Masutani Y, Aoki S, Naganawa S, Abe K.

J Stroke Cerebrovasc Dis. 2015年12月

進行性核上性麻痺における小脳歯状核のMRI信号変化

澤信宏, 形岡博史, 桐山敬生, 泉哲石, 田岡俊昭, 吉川公彦, 上野聡

臨床神経学 55 巻 ( Suppl. ) 頁： S427 - S427 2015年12月

A case of meningococcal meningitis with multiple cerebellar microbleeds detected by susceptibility-weighted imaging 査読有り国際誌 Open Access

Miyazaki, K; Fukushima, H; Kogeichi, Y; Watanabe, T; Norimoto, K; Taoka, T; Okuchi, K

BMC MEDICAL IMAGING 15 巻 ( 1 ) 頁： 45 - 45 2015年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Medical Imaging

Background: Bacterial meningitis is a fatal infectious disease of the central nervous system complicating intravascular involvements. Multiple microbleeds are rarely identified as complications because of the limited detection threshold of conventional imaging modalities. We report the first case of meningococcal meningitis with successful identification of multiple microbleeds in the cerebellum by susceptibility-weighted imaging. Case presentation: A 19-year-old Japanese female was brought to our emergency department because of fever and coma. A spinal tap was performed and turbid yellow fluid was collected. A diagnosis of bacterial meningitis was established and the patient was admitted to an intensive care unit. Dexamethasone and Antibiotics were administered and Neisseria meningitides was cultured from the spinal fluid. On day 10, postcontrast magnetic resonance imaging identified enhanced subarachnoid space in the cerebellum. Susceptibility-weighted imaging showed spotty low-intensity signals in the cerebellar tissue, indicating microbleeds. The patient made a full recovery from coma and was discharged without neurological sequelae on day 24. Conclusion: Meningococcal meningitis can cause multiple microbleeds in the cerebellum. In this report, we successfully identified microbleeds by susceptibility-weighed imaging. Using this imaging modality, further investigations will clarify its clinical incidence and significance.

DOI： 10.1186/s12880-015-0090-z

Characteristic Mill findings of upper limb muscle involvement in myotonic dystrophy type 1 査読有り

Sugie, K; Sugie, M; Taoka, T; Tonomura, Y; Kumazawa, A; Izumi, T; Ueno, S; Kichikawa, K

NEUROMUSCULAR DISORDERS 25 巻頁： S272 - S272 2015年10月

Utility of High-b-Value Diffusion-Weighted Magnetic Resonance Imaging in Evaluating Reversible Medial Longitudinal Fasciculus Syndrome Caused by Acute Brainstem Ischemia 査読有り国際誌

Miki, Y; Fujioka, M; Taoka, T; Tanaka, H; Chitoku, S; Matsuyama, T; Tanaka, S

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 24 巻 ( 6 ) 頁： E157 - E159 2015年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Stroke and Cerebrovascular Diseases

Background Medial longitudinal fasciculus (MLF) syndrome refers to a gaze disorder characterized by impaired adduction on the ipsilateral side to the injured MLF, with dissociated nystagmus of the contralateral abducting eye. The most common cause of the MLF syndrome is ischemic stroke. However, acute ischemic change in the MLF may be undetectable even on diffusion-weighted magnetic resonance imaging (DW-MRI) partly because of its small size and specific brainstem location. Case Report Herein, we present the first reported case of MLF syndrome in which, compared with the standard-b-value DWI, a higher b-value DWI revealed more clearly a small infarction in the dorsal pons in the acute stage. Conclusions We suggest that high-b-value DWI can be a useful diagnostic method for patients with MLF syndrome caused by possible brainstem ischemia and thus supportive for deciding the optimal treatment for such patients.

DOI： 10.1016/j.jstrokecerebrovasdis.2015.03.002

"Cerebellar peduncle quarter notes" formed by the superior and middle cerebellar peduncles: comparison with a diffusion tensor study of spinocerebellar degeneration 査読有り

Characteristic MRI Findings of upper Limb Muscle Involvement in Myotonic Dystrophy Type 1 査読有り Open Access

Sugie K, Sugie M, Taoka T, Tonomura Y, Kumazawa A, Izumi T, Kichikawa K, Ueno S.

PLoS One. 10 巻 ( 4 ) 頁： e0125051 2015年4月

Ochi, T; Taoka, T; Miyasaka, T; Wada, T; Sakamoto, M; Hori, S; Kichikawa, K

JAPANESE JOURNAL OF RADIOLOGY 33 巻 ( 4 ) 頁： 210 - 215 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Radiology

Purpose: To investigate morphological changes of the superior and middle cerebellar peduncles (SCP, MCP) in spinocerebellar degeneration (SCD) by observing “cerebellar peduncle quarter notes”. Materials and Methods: We examined 21 patients with SCD, including nine patients with multiple system atrophy cerebellar type (MSA-C), and 24 controls. We measured SCP angle and performed diffusion tensor analysis to quantify the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the MCP. We quantified the relationship between SCP angle and the ADC and FA of the MCP, and compared these variables between MSA-C patients and controls. Results: There was statistically significant negative correlation between SCP angle and FA of the MCP, and a positive correlation between SCP angle and the ADC of the MCP. Mean SCP angle was larger among MSA-C patients than among normal controls. Conclusions: SCP angle tended to be larger among patients with severe degeneration of the MCP. The SCP angle, quantified by observing “cerebellar peduncle quarter notes”, may be a simple index for evaluation of degeneration of the MCP.

DOI： 10.1007/s11604-015-0409-2

Comparison between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on the risk of stroke recurrence and longitudinal progression of white matter lesions and silent brain infarcts on MRI (CEREBRAL study): rationale, design, and methodology 査読有り

Yamano, S; Horii, M; Takami, T; Sakuma, M; Morimoto, T; Okada, S; Taoka, T; Kichikawa, K; Sasamura, H; Itoh, H; Furuya, Y; Ueno, S; Imamura, T; Sugiyama, S; Ogawa, H; Saito, Y

INTERNATIONAL JOURNAL OF STROKE 10 巻 ( 3 ) 頁： 452 - 456 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Stroke

Patients with a history of ischemic stroke are known to develop new ischemic stroke. While asymptomatic, the presence and progression of silent brain infarcts and white matter lesions on magnetic resonance imaging are associated with an increased risk of future strokes. Both angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are recommended for the primary and secondary prevention of stroke, but there are no direct comparisons of angiotensin-converting enzyme inhibitors versus angiotensin II receptor blockers regarding their cerebroprotective effects, including their effect on asymptomatic cerebral lesions detected by magnetic resonance imaging. Methods: Elderly (65 years or older) patients with essential hypertension who underwent cerebral magnetic resonance imaging and were found to have any cerebral ischemic lesions, such as cerebral infarction, silent brain infarct, or white matter lesion, were enrolled in this CEREBRAL study. Patients who agreed to participate were enrolled in the randomized controlled trial portion. Patients who did not agree to participate in the randomized controlled trial were enrolled in the cohort study portion. After two-years of angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers treatment, follow-up magnetic resonance imaging examination will be performed. The primary end-point is the composite of (1) occurrence of a fatal or nonfatal cerebrovascular event or (2) progression of cerebrovascular lesions as evaluated by magnetic resonance imaging, including white matter lesions or silent brain infarcts. After enrollment, cognitive function was evaluated, if possible, using the Mini-Mental State Examination. Conclusions: Our study will clarify whether angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers are more effective for preventing primary and recurrence of ischemic stroke, including the progression of asymptomatic cerebral lesions on magnetic resonance imaging, in elderly hypertensive patients.

DOI： 10.1111/ijs.12085

特集解剖学的構造を念頭においた中枢神経疾患の画像診断脳梁の病変

宮坂俊輝, 田岡俊昭

画像診断 35 巻 ( 5 ) 頁： 517 - 527 2015年3月

A Magnetic Resonance Imaging Technique to Evaluate Tumor-Brain Adhesion in Meningioma: Brain-Surface Motion Imaging 査読有り国際誌

Yamada, S; Taoka, T; Nakagawa, I; Nishimura, F; Motoyama, Y; Park, YS; Nakase, H; Kichikawa, K

WORLD NEUROSURGERY 83 巻 ( 1 ) 頁： 102 - 107 2015年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：World Neurosurgery

Objective We examined the effectiveness of a newly developed magnetic resonance imaging (MRI) technique, brain surface motion imaging (BSMI), in the preoperative evaluation of tumor-brain adhesion in meningioma surgery. Methods Cine phase-contrast MRI was used to measure cerebrospinal fluid (CSF) pulsations and heart rates at 2 different time points to create a subtraction image in meningioma patients who underwent BSMI. With no tumor-brain adhesion, a gap was observed in the tumor-brain movements, resulting in an outline of the tumor in BSMI. If adhesion was evident, no outline was observed. Cases were evaluated as exact if the presence or absence of edema in T2-weighted MRI, BSMI findings, and intraoperative findings all matched; as effected when only BSMI findings and intraoperative images matched; and as false when BSMI findings and intraoperative findings did not match. Results BSMI judged 27 patients as adhesion (+) and 33 as adhesion (-), whereas surgical findings evaluated 22 as adhesion (+) and 38 as adhesion (-). The sensitivity and specificity were both high, at 95.5% and 84.2%, respectively. Forty-one of 60 patients were evaluated as exact, 12 as effected, and 7 as false. World Health Organization tumor grade assessment of effected subjects included 16.7% in grade 1 and 36.4% in grade 2. Conclusions BSMI was shown to be effective in evaluating adhesion between the meningioma and the brain, allowing safe and effective removal planning to be carried out preoperatively.

DOI： 10.1016/j.wneu.2013.02.015