研究者詳細 - 田岡　俊昭

White matter changes in dementia with Lewy bodies and Alzheimer's disease: a tractography-based study.

Kiuchi K, Morikawa M, Taoka T, Kitamura S, Nagashima T, Makinodan M, Nakagawa K, Fukusumi M, Ikeshita K, Inoue M, Kichikawa K, Kishimoto T

Journal of psychiatric research 45 巻 ( 8 ) 頁： 1095 - 100 2011年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Psychiatric Research

Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are different types of dementia. However, their clinical symptoms partially overlap and differential diagnosis is occasionally difficult. There is need for additional diagnostic criteria to reliably differentiate between these two conditions. Meanwhile, several imaging studies have showed inconsistent results between DLB and AD. The aim of this study was to use a tractography-based analysis to elucidate white matter alterations in subjects with DLB compared to those with AD and to controls. An understanding of the white matter connectivity differences between AD, DLB and controls will be helpful for differential diagnosis and an understanding of the pathophysiology. Twenty-six subjects with DLB, 26 with AD and 26 controls underwent magnetic resonance diffusion tensor imaging and neuropsychological assessment. Diffusion tensors were computed and fiber-tract maps were created using "dTV II" software. We measured mean fractional anisotropy (FA) values along the uncinate fasciculus (UNC), the inferior occipitofrontal fasciculus (IOFF) and the inferior longitudinal fasciculus (ILF). Both subjects with DLB and AD had lower FA values for the bilateral UNC than controls. Subjects with DLB exhibited significantly lower FA values on both sides of the IOFF and the left side of the ILF than those of controls. Although there were no significant differences between subjects with DLB and AD for any measurements, those with DLB exhibited lower FA values especially in visual-related white matter. These different changes in white matter tracts among groups could be helpful for differential diagnosis and an understanding of the pathophysiology. © 2011 Elsevier Ltd.

DOI： 10.1016/j.jpsychires.2011.01.011

Prediction of periprocedual ischemic complication in carotid artery stenting with filter embolic protection device by using magnetic resonance (MR) plaque imaging 査読有り

Kichikawa, K; Takayama, K; Nakagawa, H; Miyouchinn, K; Taoka, T; Sakamoto, M; Wada, T; Kurokawa, S

JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 巻頁： 497 - 498 2011年7月

Transient hyperintensity in the subthalamic nucleus and globus pallidus of newborns on T1-weighted images.

Taoka T, Aida N, Ochi T, Takahashi Y, Akashi T, Miyasaka T, Iwamura A, Sakamoto M, Kichikawa K

AJNR. American journal of neuroradiology 32 巻 ( 6 ) 頁： 1130 - 7 2011年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Neuroradiology

BACKGROUND AND PURPOSE: In the brains of newborns, changes in signal intensity in most structures can be explained by the development of myelination. However, there are some structures for which signal intensity changes cannot be accounted for by myelination alone. We examined the STN and globus pallidus signal intensities and tried to determine whether a relationship exists between the signal intensity and the postnatal age or the gestational age at the examination. MATERIALS AND METHODS: We examined T1WI and T2WI obtained from 79 neonates who showed normal development at their 2-year follow-up examinations. We performed both qualitative and quantitative (signal intensity ratio to the thalamus) evaluation of the STN and globus pallidus signals, and we examined the correlation between signal intensity changes and the age of neonates. RESULTS: With increasing postnatal age at examination, the high signal intensity on the T1WI for both STN and globus pallidus diminished. Although the disappearance of this hyperintensity was well correlated with the postnatal age at examination for both the qualitative and quantitative studies, there was no correlation with gestational age at examination. For the T2WI, there was no correlation with either the postnatal age or the gestational age at examination. CONCLUSIONS: Signal intensity on T1WI in the STN and globus pallidus is not related to the gestational age at examination; instead, signal intensities on T1WI seem to be more dependent upon the postnatal age at examination.

DOI： 10.3174/ajnr.A2451

Characteristic neuroimaging in patients with tumefactive demyelinating lesions exceeding 30 mm.

Kiriyama T, Kataoka H, Taoka T, Tonomura Y, Terashima M, Morikawa M, Tanizawa E, Kawahara M, Furiya Y, Sugie K, Kichikawa K, Ueno S

Journal of neuroimaging : official journal of the American Society of Neuroimaging 21 巻 ( 2 ) 頁： e69 - 77 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuroimaging

BACKGROUND AND PURPOSE: Features of tumefactive demyelinating lesion (TDL) on magnetic resonance imaging (MRI) can facilitate the differential diagnosis of TDL and neoplastic lesions, but vary considerably among patients. The larger TDL grows, the more difficult it becomes to differentiate TDL from neoplastic lesions. The purpose of this study was to elucidate typical MRI features in 12 patients with large TDL (>30 mm in diameter). METHODS: We identified 12 patients with large TDL (six men, six women; age range 17-64 years, median age 27 years) and studied the clinical histories and the results of laboratory and various radiological studies in these patients. All cases of clinically definite multiple sclerosis were diagnosed in accordance with McDonald's revised criteria. RESULTS: Common MRI features of large TDLs included variable degrees of mass effect (71%) and edema (100%), a T2 hypointense rim (79%), venular enhancement (57%), and peripheral restriction on diffusion-weighted images (50%). Ring enhancement (38%), open-ring enhancement (31%), or decreased N-acetylaspartate ratios on magnetic resonance spectroscopy (22%) were less frequently observed. Brain angiography demonstrated venous dilatations on and around the TDL. CONCLUSIONS: The diagnosis of large TDL is challenging. Our findings suggest that multiple venous dilatations on and around TDLs on angiography can facilitate diagnosis. © 2010 by the American Society of Neuroimaging.

DOI： 10.1111/j.1552-6569.2010.00502.x

Initial experience of carotid artery stenting using the Carotid WALLSTENT and FilterWire EZ in Japan

Takayama, K; Taoka, T; Nakagawa, H; Myouchin, K; Wada, T; Miyasaka, T; Sakamoto, M; Fukusumi, A; Iwasaki, S; Kimura, R; Kurokawa, S; Kichikawa, K

JAPANESE JOURNAL OF RADIOLOGY 29 巻 ( 1 ) 頁： 51 - 58 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Radiology

Purpose: The Carotid WALLSTENT (CWS) and Filter-Wire EZ (FWEZ) embolic protection devices for use in carotid arterial stenting (CAS) were newly approved for national health insurance coverage in Japan in April 2010. This article describes our initial experience of CAS using the CWS and FWEZ. Material and methods: A group of 14 patients (12 men, 2 women; mean age 70.1 years, range 59-83 years) with 15 carotid artery stenoses at high risk for carotid endarterectomy were treated by CAS using the CWS and FWEZ. Of these stenoses, 5 were symptomatic with ≥50% stenosis of the common or internal carotid artery (ICA), and 10 were asymptomatic with ≥80% stenosis. The rates of technical success, ICA flow impairment during filter protection, periprocedural ischemic stroke, 30-day major adverse events (MAEs) (stroke, death, myocardial infarction), and development of new ischemic lesions on diffusion-weighted imaging (DWI) were assessed. Results: CAS was successful in all cases. There was no ICA flow impairment, periprocedural ischemic stroke, or MAEs. DWI showed new ipsilateral ischemic lesions in only one patient (6.7%). Conclusion: Our initial clinical experience using the CWS and FEWZ for CAS was generally excellent, and the incidence of postprocedural ischemic lesions was low. © 2011 Japan Radiological Society.

DOI： 10.1007/s11604-010-0518-x

Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with a History of Brain Irradiation 査読有り国際誌

Kasahara, S; Miki, Y; Kanagaki, M; Yamamoto, A; Mori, N; Sawada, T; Taoka, T; Okada, T; Togashi, K

RADIOLOGY 258 巻 ( 1 ) 頁： 222 - 228 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Radiology

Purpose: To assess the frequency of hyperintensity in the dentate nucleus on T1-weighted magnetic resonance (MR) images and to establish correlations between such hyperintensity and clinical factors, including a history of brain irradiation. Materials and Methods: This study was approved by the institutional review board, and each patient provided written informed consent. Three hundred sixty-two patients (164 men, 198 women; mean age, 62 years) were evaluated. Unenhanced T1-weighted MR images were obtained by using a spin-echo sequence at 3.0 T. Two neuroradiologists, who were blinded to clinical data, independently evaluated the signal intensity of the dentate nucleus compared with the signal intensity of the central white matter of the cerebellum by using a four-point graded response scale (grade 4 indicated prominent hyperintensity; grade 3, faint hyperintensity; grade 2, isointensity; and grade 1, hypointensity). Backward stepwise regression analysis was used to evaluate the relationship between signal intensity grades and the following clinical factors: sex, age, the interaction between age and sex, hypertension, dyslipidemia, diabetes mellitus, liver dysfunction, brain infarction, brain tumor, spinocerebellar degeneration, multiple sclerosis, a history of chemotherapy, and a history of brain irradiation. Results: T1-hyperintense dentate nuclei were present in 41 (11%) of the 362 patients. Of these 41 patients, 31 (76%) had a history of brain irradiation. Signal intensity grade of the dentate nucleus on T1-weighted MR images correlated significantly with a history of brain irradiation (P <.001) but no other clinical factor. Conclusion: A hyperintense dentate nucleus may be seen on unenhanced T1-weighted MR images in some patients and may be associated with a history of brain irradiation. © RSNA, 2010.

DOI： 10.1148/radiol.10100508

Serial neuroimaging in tolosa-hunt syndrome with acute bilateral complete ophthalmoplegia.

Sugie K., Morikawa M., Taoka T., Hirano M., Ueno S.

Journal of neuroimaging : official journal of the American Society of Neuroimaging 21 巻 ( 1 ) 頁： 79 - 82 2011年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of neuroimaging : official journal of the American Society of Neuroimaging

Tolosa-Hunt syndrome (THS) is a very rare, relapsing, and remitting painful ophthalmoplegia caused by nonspecific granulomatous inflammation in the cavernous sinus. To our knowledge, bilateral complete, simultaneous palsies of all 3 cranial nerves associated with extraocular movement have not been reported. We describe the first such patient with bilateral THS that responded quickly to corticosteroid therapy. A 54-year-old man presented with a periorbital and frontal headache with acute bilateral severe blepharoptosis and fixed eyes, which dramatically responded to corticosteroid therapy. He had diabetes mellitus type II. Brain MRI showed granulomatous inflammation in both cavernous sinuses and thickening of the surrounding dura mater of the cranial base, suggesting the coexistence of focal hypertrophic cranial pachymeningitis. Our experience indicates that steroid therapy with strict control of blood sugar should be considered in patients with THS complicated by diabetes. MRI is a valuable tool for serially monitoring the response of lesions to treatment in THS.

DOI： 10.1111/j.1552-6569.2009.00381.x

Discrepancy in T1 and T2 Shortening of the Globus Pallidus in Hepatic Insufficiency: Evaluation by Susceptibility-weighted Imaging

Ochi, T; Taoka, T; Akashi, T; Sakamoto, M; Miyasaka, T; Wada, T; Nakagawa, H; Takehana, K; Tatsuno, K; Kichikawa, K

MAGNETIC RESONANCE IN MEDICAL SCIENCES 10 巻 ( 2 ) 頁： 79 - 83 2011年

Discrepancy in T1 and T2 Shortening of the Globus Pallidus in Hepatic Insufficiency: Evaluation by Susceptibility-weighted Imaging

OCHI Tomoko, TAOKA Toshiaki, AKASHI Toshiaki, SAKAMOTO Masahiko, MIYASAKA Toshiteru, WADA Takeshi, NAKAGAWA Hiroyuki, TAKEHANA Keiichi, TATSUNO Kentaro, KICHIKAWA Kimihiko

Magnetic Resonance in Medical Sciences 10 巻 ( 2 ) 頁： 79 - 83 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society for Magnetic Resonance in Medicine

Purpose: We assessed the signal of the globus pallidus (GP) in cases of hepatic insufficiency, especially to evaluate the degree of discrepancy in paramagnetic effects on shortening of T1 and T2* using susceptibility-weighted images (SWI). Materials and Methods: Seven patients with hepatic insufficiency underwent magnetic resonance (MR) examinations that included T1-weighted images (T1WI), T2-weighted images (T2WI), and SWI on a 1.5-tesla MR imager, and we compared their results to those of controls. On T1WI and T2WI, we measured signal intensity in the GP and posterior segment of the putamen (Put) to obtain a signal ratio (GP/Put ratio), and on SWI, we classified signal intensity into 4 grades: A, higher than the cortex; B, lower than the cortex and higher than the cerebrospinal fluid (CSF); C, lower than the CSF and higher than the red nucleus; and D, lower than the red nucleus. Results: In the 7 patients with hepatic insufficiency, the mean GP/Put ratio was significantly higher on T1WI and T2WI than those values in controls. On SWI, we classified 2 cases each as Grade A, Grade B, and Grade C, and one as Grade D. Although the signal of the GP was elevated on T1WI, there was no decrease in signal on T2WI. On SWI, we obtained no low signal intensity. Conclusion: In patients with hepatic insufficiency, the globus pallidus did not show low signal intensity on either T2WI or SWI. Hyperintensity of the GP on T1WI without hypointensity on T2WI, or even SWI, suggests a discrepancy between paramagnetic effect on T1 and T2 shortening that reflects the accumulation of manganese and the presence of hepatic insufficiency.

DOI： 10.2463/mrms.10.79

CiNii Research

White matter changes in dementia with Lewy bodies and Alzheimer's disease: A tractgraphy-based study 査読有り

Kitamura, S; Kiuchi, K; Morikawa, M; Taoka, T; Nagashima, T; Yamamuro, K; Yoshino, H; Takeda, T; Sadamatsu, M; Kichikawa, K; Kishimoto, T

NEUROSCIENCE RESEARCH 71 巻頁： E289 - E289 2011年

Reduced white matter integrity in attention-deficit hyperactivity disorder Whole-brain voxel-wise investigation 査読有り

Inoue, M; Kiuchi, K; Nagashima, T; Taoka, TI; Kichikawa, K; Kishimoto, T

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 28 巻 ( 8 ) 頁： 712 - 712 2010年12月

Brain surface motion imaging to predict adhesions between meningiomas and the brain surface. 国際誌

Taoka T, Yamada S, Yamatani Y, Akashi T, Miyasaka T, Emura T, Nakase H, Kichikawa K

Neuroradiology 52 巻 ( 11 ) 頁： 1003 - 10 2010年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroradiology

Introduction "Brain surface motion imaging" (BSMI) is the subtraction of pulse-gated, 3D, heavily T2-weighted image of two different phases of cerebrospinal fluid (CSF) pulsation, which enables the assessment of the dynamics of brain surface pulsatile motion. The purpose of this study was to evaluate the feasibility of this imaging method for providing presurgical information about adhesions between meningiomas and the brain surface. Methods Eighteen cases with surgically resected meningioma in whom BSMI was presurgically obtained were studied. BSMI consisted of two sets of pulse-gated, 3D, heavily T2-weighted, fast spin echo scans. Images of the systolic phase and the diastolic phase were obtained, and subtraction was performed with 3D motion correction. We analyzed the presence of band-like texture surrounding the tumor and judged the degree of motion discrepancy as "total," "partial," or "none." The correlation between BSMI and surgical findings was evaluated. For cases with partial adhesions, agreements in the locations of the adhesions were also evaluated. Results On presurgical BSMI, no motion discrepancy was seen in eight cases, partial in six cases, and total in four cases. These presurgical predictions about adhesions and surgical findings agreed in 13 cases (72.2%). The locations of adhesions agreed in five of six cases with partial adhesions. Conclusion In the current study, BSMI could predict brain and meningioma adhesions correctly in 72.2% of cases, and adhesion location could also be predicted. This imaging method appears to provide presurgical information about brain/meningioma adhesions. © Springer-Verlag 2010.

DOI： 10.1007/s00234-010-0671-z

A patient with IgG4-related disease detected due to the presence of optic disc edema

Yukawa E., Nitta N., Taoka T., Morita K., Nishi T., Hara Y.

Folia Japonica de Ophthalmologica Clinica 3 巻 ( 11 ) 頁： 1207 - 1210 2010年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Folia Japonica de Ophthalmologica Clinica

We encountered a patient who showed optic disc edema and was finally diagnosed with IgG4-related disease. An 81-year-old male with cataract was referred to our department for surgery. At the time of the initial consultation, edema was observed in the bilateral optic discs. Brain magnetic resonance imaging revealed hypophysitis and hypertrophic cranial pachymeningitis. Close examination of the entire body showed interstitial nephritis and a lung lesion. In addition, since the IgG4 level was high, a final diagnosis of IgG4-related disease was made. In recent years, IgG4-related disease has attracted attention as a systemic disease. In the future, when optic disc edema is observed, hypertrophic cranial pachymeningitis and IgG4-related disease should also be taken into consideration, and close examination of the entire body in cooperation with other departments may also be necessary.

FilterWireEZ保護下でのPreciseおよびWallstentを用いた再CASの一例

中川裕之, 宮坂俊輝, 和田敬, 坂本雅彦, 田岡俊昭, 吉川公彦, 中川一郎, 明珍薫, 高山勝年

JNET: Journal of Neuroendovascular Therapy 4 巻 ( 4 ) 頁： 291 - 291 2010年11月

内頸動脈起始部高度狭窄に対するステント留置術中に総頸動脈起始部狭窄を発見し、血管拡張術を併用して治療に成功した1例

和田敬, 高山勝年, 中川裕之, 宮坂俊輝, 明珍薫, 坂本雅彦, 田岡俊昭, 吉川公彦, 黒川紳一郎

JNET: Journal of Neuroendovascular Therapy 4 巻 ( 4 ) 頁： 367 - 367 2010年11月

Biphasic paraneoplastic brainstem encephalitis associated with anti-Ri antibody.

Tesseki K, Kataoka H, Terashima M, Kawahara M, Taoka T, Tanaka K, Ueno S

Journal of neuro-oncology 100 巻 ( 1 ) 頁： 141 - 3 2010年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuro-Oncology

Brainstem encephalitis is not a classic paraneoplastic syndrome and usually involves monophasic neurological deterioration and has negative magnetic resonance imaging (MRI) findings. We describe a patient with brainstem encephalitis who had elevated anti-Ri antibody levels and double-step neurological deterioration associated with different abnormal lesions on MRI. Immunosuppression with steroids and intravenous immune globulin combined with aggressive treatment of the tumor successfully led to the resolution of brainstem symptoms and MRI lesions. In patients with unusual signs and symptoms of paraneoplastic encephalitis mimicking multiple sclerosis, onconeural antibody studies are recommended. © 2010 Springer Science+Business Media, LLC.

DOI： 10.1007/s11060-010-0135-7