研究者詳細 - 田岡　俊昭

A patient with IgG4-related disease detected due to the presence of optic disc edema

Yukawa E., Nitta N., Taoka T., Morita K., Nishi T., Hara Y.

Folia Japonica de Ophthalmologica Clinica 3 巻 ( 11 ) 頁： 1207 - 1210 2010年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Folia Japonica de Ophthalmologica Clinica

We encountered a patient who showed optic disc edema and was finally diagnosed with IgG4-related disease. An 81-year-old male with cataract was referred to our department for surgery. At the time of the initial consultation, edema was observed in the bilateral optic discs. Brain magnetic resonance imaging revealed hypophysitis and hypertrophic cranial pachymeningitis. Close examination of the entire body showed interstitial nephritis and a lung lesion. In addition, since the IgG4 level was high, a final diagnosis of IgG4-related disease was made. In recent years, IgG4-related disease has attracted attention as a systemic disease. In the future, when optic disc edema is observed, hypertrophic cranial pachymeningitis and IgG4-related disease should also be taken into consideration, and close examination of the entire body in cooperation with other departments may also be necessary.

FilterWireEZ保護下でのPreciseおよびWallstentを用いた再CASの一例

中川裕之, 宮坂俊輝, 和田敬, 坂本雅彦, 田岡俊昭, 吉川公彦, 中川一郎, 明珍薫, 高山勝年

JNET: Journal of Neuroendovascular Therapy 4 巻 ( 4 ) 頁： 291 - 291 2010年11月

内頸動脈起始部高度狭窄に対するステント留置術中に総頸動脈起始部狭窄を発見し、血管拡張術を併用して治療に成功した1例

和田敬, 高山勝年, 中川裕之, 宮坂俊輝, 明珍薫, 坂本雅彦, 田岡俊昭, 吉川公彦, 黒川紳一郎

JNET: Journal of Neuroendovascular Therapy 4 巻 ( 4 ) 頁： 367 - 367 2010年11月

Biphasic paraneoplastic brainstem encephalitis associated with anti-Ri antibody.

Tesseki K, Kataoka H, Terashima M, Kawahara M, Taoka T, Tanaka K, Ueno S

Journal of neuro-oncology 100 巻 ( 1 ) 頁： 141 - 3 2010年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuro-Oncology

Brainstem encephalitis is not a classic paraneoplastic syndrome and usually involves monophasic neurological deterioration and has negative magnetic resonance imaging (MRI) findings. We describe a patient with brainstem encephalitis who had elevated anti-Ri antibody levels and double-step neurological deterioration associated with different abnormal lesions on MRI. Immunosuppression with steroids and intravenous immune globulin combined with aggressive treatment of the tumor successfully led to the resolution of brainstem symptoms and MRI lesions. In patients with unusual signs and symptoms of paraneoplastic encephalitis mimicking multiple sclerosis, onconeural antibody studies are recommended. © 2010 Springer Science+Business Media, LLC.

DOI： 10.1007/s11060-010-0135-7

Anatomical Evaluation of the Dural Sinuses in the Region of the Torcular Herophili Using Three Dimensional CT Venography 査読有り国際誌

Fukusumi, A; Okudera, T; Takahashi, S; Taoka, T; Sakamoto, M; Nakagawa, H; Takayama, K; Kichikawa, K; Iwasaki, S

ACADEMIC RADIOLOGY 17 巻 ( 9 ) 頁： 1103 - 1111 2010年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Academic Radiology

Rationale and Objectives: The torcular herophili, or " confluence of the sinuses," shows various configurations with other venous sinuses, as revealed by angiography. The aims of this study were to evaluate anatomic variations of this confluence and to assess their clinical relevance using three-dimensional (3D) computed tomographic (CT) venography. Materials and Methods: The torcular herophili and its relevant venous sinuses were analyzed using 3D CT venography in 120 adults, consisting of 76 patients who were proven to have aneurysms and 44 patients who were proven to have no vascular malformations or aneurysms after the examinations. Three-dimensional CT venography was performed following the arterial phase of 3D CT angiography without any additional injection of contrast material. Three-dimensional volume-rendered venous images were reconstructed on a workstation and reviewed. Results: The superior sagittal sinus (SSS) drained into the transverse sinus (TS) in four patterns: the SSS reached the centrally located confluence, where it divided into the bilateral TS (20.0%); the SSS was prematurely duplicated into the right and left limbs and drained into the same side TS (26.7%); the SSS drained exclusively into the right TS (44.2%); or the SSS drained exclusively into the left TS (9.2%). The draining pattern of the straight sinus was also classified into four types. The right TS was larger than the left TS. The right TS were higher compared to the left TS. Persistent occipital sinuses were recognized in 57.5% of the subjects. Finally, persistent falcial sinuses were seen in 2.5% of the subjects. A septum in the SSS and complicated venous channels in the confluence were each seen in only one case. Conclusion: Three-dimensional CT venography is useful as a noninvasive method to evaluate the confluence and its relevant dural sinuses and can provide useful information for surgical intervention. © 2010 AUR.

DOI： 10.1016/j.acra.2010.04.020

Hepatocellular carcinoma of the iliac bone with unknown primary. 国際誌

Takahama J, Taoka T, Marugami N, Anai H, Kitano S, Kichikawa K, Nonomura A

Skeletal radiology 39 巻 ( 7 ) 頁： 721 - 4 2010年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Skeletal Radiology

We report a case of hepatocellular carcinoma of the iliac bone in which the primary tumor was not detected. No malignant primary lesions such as hepatocellular carcinoma or hepatoid carcinoma were detected at the time or during 10 years' follow-up. In this case, transcatheter arterial chemoembolization and radiation therapy resulted in complete regression of the iliac bone tumor and in long-term survival. We focus in particular on the clinical, histological, and therapeutic aspects of the presented case, as well as the imaging and diagnostic aspects. © ISS 2010.

DOI： 10.1007/s00256-010-0891-7

Artery-to-artery embolism with a mobile mural thrombus due to rotational vertebral artery occlusion. Open Access

Saito K, Hirano M, Taoka T, Nakagawa H, Kitauchi T, Tanizawa E, Yoshida K, Sakurai Y, Tamura K, Nakase H, Yoshioka A, Sakaki T, Kichikawa K, Ueno S

Journal of neuroimaging : official journal of the American Society of Neuroimaging 20 巻 ( 3 ) 頁： 284 - 6 2010年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Neuroimaging

Rotational vertebral artery (VA) occlusion can cause ischemic strokes due to hemodynamic insufficiency and possibly artery-to-artery (A-to-A) embolism. The former is known as bow hunter's stroke. The latter has been proposed only from indirect evidence. We have described a 7-year-old boy with cerebral infarction associated with A-to-A embolism due to repetitive rotational VA occlusion. He had a mobile mural thrombus at the VA occlusion site on head rotation. Surgical treatment may effectively prevent recurrences. © 2008 by the American Society of Neuroimaging.

DOI： 10.1111/j.1552-6569.2008.00309.x

Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures.

Sakamoto M, Taoka T, Nakagawa H, Takayama K, Wada T, Myouchin K, Akashi T, Miyasaka T, Fukusumi A, Iwasaki S, Kichikawa K

Neuroradiology 52 巻 ( 4 ) 頁： 275 - 83 2010年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroradiology

Introduction The purpose is to investigate the feasibility of magnetic resonance (MR) plaque imaging in predicting the marterial flow impairment (slow-flow phenomenon) during carotid artery stenting (CAS) using a filter-type protection device. Methods Thirty-one carotid artery stenotic lesions in 30 patients (28 men and two women; mean age, 71.8 years) were evaluated by MR plaque imaging with black blood T1- and T2-weighted and time-of-flight sequences before CAS. Main plaque components were classified as vulnerable (intraplaque hemorrhage and lipid-rich/necrotic core) or stable (fibrous tissue and dense calcification) from the signal pattern. The plaque classification was statistically compared with the occurrence of slow-flow phenomenon. Results The slow-flow phenomenon was observed in ten CAS procedures (five flow arrests and five flow reductions). Flow arrests consisted of four vulnerable and one stable plaque, and flow reductions consisted of four vulnerable and one stable plaque. The slow-flow phenomenon occurred significantly (P<0.01) more frequently in patients with vulnerable plaque. Conclusions Vulnerable carotid plaques have a significantly higher risk of slow-flow phenomenon than stable plaques. The occurrence of the slow-flow phenomenon can be predicted by MR plaque imaging before CAS © Springer-Verlag 2009.

DOI： 10.1007/s00234-009-0623-7

Uncinate fasciculus-correlated cognition in Alzheimer's disease: A diffusion tensor imaging study by tractography

Morikawa M., Kiuchi K., Taoka T., Nagauchi K., Kichikawa K., Kishimoto T.

Psychogeriatrics 10 巻 ( 1 ) 頁： 15 - 20 2010年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Psychogeriatrics

Background: Neuroimaging studies show increased diffusivity and decreased anisotropy in Alzheimer's disease (AD) patients by diffusion tensor imaging (DTI). Previous reports have analyzed a correlation with cognitive function and DTI parameters, but their results are inconsistent. A reason for this might be a region of interest (ROI) method, used to calculate parameters for DTI, because this method has various usages of how to place a ROI and includes summations of values for various neuronal fiber tracts, resulting in contamination of unintended fibers. To improve the instability with ROI placement, a tractography-based method might be useful. Our coworker reported decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) of uncinate fasciculus (UF) in patients with AD by tractography. To confirm whether DTI parameter values are related to severity of cognitive function in patients with AD, we measured mean diffusion anisotropy and diffusivity of coregistered voxels along the tracking lines (i.e. tract of interest) of UF. Methods: The subjects were 30 patients with probable AD (NINCDSADRDA criteria). Assessment of cognitive function was carried out according to the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-cognitive component-Japanese version (ADAS-Jcog). A 1.5-T clinical magnetic resonance unit was used to obtain diffusion tensor images. Diffusion tensors were computed and fiber-tract maps were created using 'dTV II' DTI software developed by Masutani et al. We measured mean FA and ADC values along the bilateral UF. Results: FA values were positively correlated with MMSE score (r = 0.67) and were negatively correlated with ADAS-Jcog score (r = -0.62), while ADC values were negatively correlated with MMSE score (r = -0.58) and were positively correlated with ADAS-Jcog score (r = 0.59). Conclusion: FA and ADC values might reflect the severity of cognitive dysfunction. The tract-of-interest method might be a useful tool for objectively evaluating DTI parameters in AD. © 2010 The Authors Journal compilation © 2010 Japanese Psychogeriatric Society.

DOI： 10.1111/j.1479-8301.2010.00312.x

Magnetic resonance angiography with midsagittal saturation for the assessment of blood flow from superficial temporal artery-to-middle cerebral artery bypass.

Akashi T, Taoka T, Miyasaka T, Myochin K, Sakamoto M, Takayama K, Nakagawa H, Kichikawa K

Journal of computer assisted tomography 34 巻 ( 1 ) 頁： 89 - 92 2010年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Computer Assisted Tomography

Objective: The purpose of this study was to evaluate the feasibility of magnetic resonance angiography (MRA) with midsagittal saturation for depiction of superficial temporal artery-to-middle cerebral artery bypass flow. Methods: Eleven patients undergoing bypass surgery in 13 regions were examined by external carotid artery angiography (ECAG) and 3-dimensional time-of-flight MRA with saturation pulse applied to the midsagittal plane covering the internal carotid arteries. We classified the extent of visualization of bypass flow into 4 types and examined the agreement of findings between them. Results: The MRA revealed types of bypass flow in agreement with those observed on ECAG in 10 of the 13 regions. The MRA underestimated bypass flow in 2 regions and overestimated it in 1 region. Conclusions: The MRA with midsagittal saturation demonstrated bypass flow in agreement with ECAG in most cases. Application of MRA with midsagittal saturation permits noninvasive assessment of physiological flow from superficial temporal artery-to-middle cerebral artery bypass for a postoperative follow-up. Copyright © 2010 by Lippincott Williams & Wilkins.

DOI： 10.1097/RCT.0b013e3181ac914e

Juvenile Bow Hunter's Stroke without Hemodynamic Changes. 査読有り

Saito K, Hirano M, Taoka T, Nakagawa H, Kitauchi T, Ikeda M, Tanizawa E, Kichikawa K, Ueno S

Clinical medicine insights. Case reports 3 巻頁： 1 - 4 2010年1月

Brain structural change in polydipsic schizophrenia 査読有り

Nagashima T, Inoue M, Kitamura S, Kiuchi K, Kosaka J, Ikawa D, Takeda T, Kimoto S, Hirota N, Taoka T, Kichikawa K, Kishimoto T

Society for Neuroscience Abstract Viewer and Itinerary Planner 40 巻 2010年

Imaging and Tissue Characterization of Atherosclerotic Carotid Plaque Using MR Imaging 査読有り

Taoka, T

NEUROVASCULAR IMAGING: MRI & MICROANGIOGRAPHY 頁： 319 - 343 2010年

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Neurovascular Imaging: MRI and Microangiography

The carotid bifurcation is a frequent site for atheromatous diseases, and severe stenosis or occlusion of the bifurcation leads to hypoperfusion of the brain [5]. Progression of carotid artery disease relates closely to future cerebral or coronary infarction; stability of the carotid plaque and degree of carotid stenosis are important factors in disease development and assessment. Diagnosis of unstable plaque (vulnerable plaque) is important because its presence may lead to embolic diseases in the brain. Both the size and composition of plaque influence its stability [13]. Histological characteristics of unstable plaque include a large necrotic core that contains a large amount of cholesterol ester, intraplaque hemorrhage, and/or infiltration by inflammatory cells. Diagnosis of carotid plaque should be aimed at evaluating the degree of fibrosis, thrombosis, existence of lipid or calcification, and degree of stenosis or plaque thickness. In addition, the Rotterdam Study of more than 4,000 neurologically asymptomatic subjects aged 55 years or older associated carotid plaque with increased risk of stroke, irrespective of plaque location. Study results suggest that carotid plaque in such subjects is a marker of generalized atherosclerosis and a source of thrombotic emboli [20]. © 2011 Springer-Verlag London Limited.

DOI： 10.1007/978-1-84882-134-7_11

Juvenile bow hunter's stroke without hemodynamic changes

Saito K., Hirano M., Taoka T., Nakagawa H., Kitauchi T., Ikeda M., Tanizawa E., Kichikawa K., Ueno S.

Clinical Medicine Insights: Case Reports 3 巻頁： 1 - 4 2010年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Medicine Insights: Case Reports

Bow hunter's stroke (BHS) is a cerebrovascular disease caused by occlusion of the vertebral artery (VA) on head rotation. BHS is generally associated with hemodynamic changes, often leading to vertebrobasilar insufficiency symptoms, such as vertigo and faintness. Although artery-to-artery embolism has also been proposed as an underlying mechanism, it remains controversial. This report documents a case of BHS without hemodynamic changes. We describe a 26-year-old male patient who had VA occlusion on head rotation and repetitive infarction of thalami. He had an anomalous bypass of the VA and therefore no symptomatic hemodynamic changes. Thus, non-hemodynamic BHS should be considered in juvenile patients with vertebrobasilar stroke. © the authors, publisher and licensee Libertas Academica Ltd.

DOI： 10.4137/ccrep.s3555

Carotid artery stenosis with intraluminal thrombus discovered during carotid artery stenting

Juvenile Bow Hunter's Stroke without Hemodynamic Changes. 査読有り

Saito Kozue, Hirano Makito, Taoka Toshiaki, Nakagawa Hiroyuki, Kitauchi Takanori, Ikeda Masanori, Tanizawa Emi, Kichikawa Kimihiko, Ueno Satoshi

Clinical medicine insights. Case reports 3 巻頁： 1 - 4 2010年

Takayama K., Taoka T., Nakagawa H., Miyasaka T., Myouchin K., Wada T., Sakamoto M., Akashi T., Kichikawa K.

Japanese Journal of Radiology 27 巻 ( 9 ) 頁： 367 - 370 2009年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Radiology

A 77-year-old man presented with transient motor weakness of the left hand. Cerebral angiography showed 90% stenosis at the origin of the right internal carotid artery. Carotid artery stenting (CAS) was performed 3 weeks later, and a large intraluminal thrombus was found during the procedure. The blood around the thrombus was aspirated using an aspiration catheter under distal protection with a filter wire protection device, and CAS was successfully performed without complications. Although this patient was treated by CAS without complications, carotid stenosis associated with intraluminal thrombus-because it has a high risk of distal embolism-should be carefully diagnosed immediately before CAS. © 2009 Japan Radiological Society.

DOI： 10.1007/s11604-009-0348-x

Superior clinical impact of FDG-PET compared to MRI for the follow-up of a patient with sacral lymphoma. 査読有り

Yamamoto Y, Taoka T, Nakamine H

Journal of clinical and experimental hematopathology : JCEH 49 巻 ( 2 ) 頁： 109 - 115 2009年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research

The assessment of residual tumors after treatment of malignant lymphoma (ML) is often difficult. Here we report a case of non-Hodgkin's lymphoma with a huge sacral tumor. After chemotherapy and following radiation therapy, a residual mass was detected on magnetic resonance imaging (MRI). However, a hypermetabolic lesion in the sacrum disappeared on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and clinically the patient was considered to achieve complete remission. Seven months after the completion of radiation therapy, a new tumor-like lesion in the sacrum developed on MRI, but hypermetabolic lesions were not detected on 18F-FDG-PET. Recurrence of lymphoma was denied by open biopsy of the lesion. 18F-FDG-PET has been of widespread use not only for staging but for post-treatment assessment of ML. Although MRI is a standard imaging tool for the assessment of bone involvement of ML, there have been few reports documenting the results of comparative studies on the usefulness of 18F-FDG-PET and MRI for the evaluation of residual mass in bone involvement of ML. The present case suggests that 18F-FDG-PET is superior to MRI not only in the evaluation of a residual mass but in the judgment of recurrence after treatment of such patients. [J Clin Exp Hematopathol 49(2) : 109-115, 2009]

DOI： 10.3960/jslrt.49.109