Faculty Profiles - UCHIDA Hiroo

Papers - UCHIDA Hiroo

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Safe thoracoscopic repair of recurrent congenital diaphragmatic hernia after initial open abdominal repair Reviewed

Gohda, Y; Yokota, K; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Maeda, T; Guo, YH; Hinoki, A

SURGERY TODAY 2023.10

Refractory esophageal anastomotic stricture after esophageal atresia surgery improved with retrograde balloon dilatation through gastrostomy followed by laparoscopic fundoplication: a case report Reviewed

Nakagawa, Y; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Makita, S; Yokota, K; Amano, H; Yasui, A; Kato, D; Gohda, Y; Maeda, T

SURGICAL CASE REPORTS Vol. 9 ( 1 ) page： 169 2023.9

How many cases do instructor class pediatric surgeons need to experience to be an independent operator in performing advanced endoscopic surgery? A nationwide survey to establish an ideal curriculum for pediatric endoscopic surgery in Japan Reviewed

Murakami, M; Onishi, S; Yamada, K; Ogawa, K; Yokoyama, S; Kurashima, Y; Miyano, G; Ishimaru, T; Kawashima, H; Uchida, H; Yamataka, A; Okuyama, H; Ieiri, S

PEDIATRIC SURGERY INTERNATIONAL Vol. 39 ( 1 ) page： 271 2023.9

Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience Reviewed

Maeda, T; Liu, JH; Uchida, H; Amano, H; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gouda, A; Guo, YH; Hinoki, A

PEDIATRIC SURGERY INTERNATIONAL Vol. 39 ( 1 ) page： 261 2023.9

Management of congenital and postoperative chylothorax: Use of thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography. Reviewed International journal

Shunya Takada, Chiyoe Shirota, Hiroo Uchida, Hizuru Amano, Akinari Hinoki, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Aitaro Takimoto, Akihiro Yasui, Youichi Nakagawa, Daiki Kato, Yaohui Guo, Takahisa Tainaka

Journal of pediatric surgery Vol. 58 ( 9 ) page： 1754 - 1761 2023.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Congenital chylothorax (CCT) and postoperative chylothorax (POCT) are rare and difficult to treat. We report our treatment strategy and outcomes for chylothorax, including thoracoscopic surgery with indocyanine-green (ICG) near-infrared fluorescence lymphangiography. METHODS: A retrospective review of patients with CCT and POCT from 2014 to 2021 was performed. After definitive diagnosis, conservative treatments with octreotide, followed by intravenous steroids as needed, were performed. Patients who were refractory to conservative treatment were transferred to surgical treatment, consisting of thoracoscopic lymphatic leak ligations using ICG intraoperative lymphangiography. The effectiveness of conservative and surgical treatment was then examined. RESULTS: We included 19 cases of CCT and 31 cases of POCT. The 31 POCT patients included 23 of 84 postoperative patients with congenital diaphragmatic hernia (CDH), 7 of 54 postoperative patients with esophageal atresia (EA), and 1 of 3 postoperative patients with lymphatic malformation. The efficacy of conservative treatment was 12/19 for CCT, 22/23 for CDH, and 4/7 for EA. Surgical intervention was performed in 10 patients, and the rate of resolution of chylothorax within 3 weeks after surgery was 90%. CONCLUSION: Thoracoscopic lymphatic leak ligations with intraoperative ICG lymphangiography are feasible and useful in patients with chylothorax refractory to conservative treatment. LEVEL OF EVIDENCE: Level IV.

DOI： 10.1016/j.jpedsurg.2022.11.018

Web of Science

PubMed

Comprehension of fundamental knowledge about pediatric endoscopic surgery: a cross-sectional study in Japan Reviewed

Yokoyama, S; Kurashima, Y; Ieiri, S; Yamataka, A; Okuyama, H; Uchida, H; Ishimaru, T; Hirano, S

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES Vol. 37 ( 8 ) page： 6408 - 6416 2023.8

BMC PEDIATRICS Vol. 23 ( 1 ) page： 376 2023.7

特集急性虫垂炎:診断,治療,研究複雑性虫垂炎の緊急手術 Reviewed

田井中貴久, 城田千代栄, 住田亙, 横田一樹, 牧田智, 岡本眞宗, 小梛地洋, 長島俊介, 檜顕成, 内田広夫

小児外科 Vol. 55 ( 7 ) page： 751 - 754 2023.7

Case report: Laparoscopic gastrojejunostomy for duodenal atresia with situs inversus and preduodenal portal vein: a report of two cases Reviewed

Nakagawa, Y; Sumida, W; Makita, S; Uchida, H; Hinoki, A; Shirota, C; Tainaka, T; Yokota, K; Amano, H; Yasui, A; Takimoto, A; Kato, D; Maeda, T; Gohda, Y

FRONTIERS IN PEDIATRICS Vol. 11 page： 1220393 2023.6

Case Report: Retropancreatic fascia hernia protruding into the thoracic cavity through a Bochdalek hernia Reviewed

Nakagawa, Y; Maeda, T; Uchida, H; Takada, S; Hinoki, A; Shirota, C; Tainaka, T; Sumida, W; Makita, S; Amano, H; Takimoto, A; Gohda, Y

FRONTIERS IN PEDIATRICS Vol. 11 page： 1149515 2023.6

Preoperative Contrast Examinations Help Determine the Appropriate Cervical Approach for Congenital Gross Type C Esophageal Atresia: A Report of Two Cases Reviewed

Nakagawa, Y; Uchida, H; Shirota, C; Tainaka, T; Sumida, W; Amano, H; Takimoto, A; Ogata, S; Takada, S; Maeda, T; Gohda, Y; Guo, YH; Hinoki, A

AMERICAN JOURNAL OF CASE REPORTS Vol. 24 page： e938723 2023.6

CLINICAL VALIDATION OF NOVEL URINARY MARKERS FOR NEUROBLASTOMA DIAGNOSIS Reviewed

Hiroo UCHIDA

Pediatric Blood and Cancer Vol. 70 page： S95 - S95 2023.6

特集ロボット支援手術ロボット支援下胆管切除術 Reviewed

牧田智, 内田広夫, 住田亙, 檜顕成, 城田千代栄, 田井中貴久, 天野日出, 滝本愛太朗, 高田瞬也, 中川洋一, 合田陽祐, 前田拓也, 郭垚輝, 劉佳慧

小児外科 Vol. 55 ( 5 ) page： 544 - 551 2023.5

特集ロボット支援手術小児外科領域におけるプロクター制度 Invited

内田広夫

小児外科 Vol. 55 ( 5 ) page： 497 - 501 2023.5

Hemi-circumferential mucosal resection and anastomosis procedure for rectal prolapse following anorectoplasty for anorectal malformations. Reviewed

Aitaro Takimoto, Hizuru Amano, Chiyoe Shirota, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Seiya Ogata, Shunya Takada, Yoichi Nakagawa, Daiki Kato, Yosuke Gohda, Akinari Hinoki, Hiroo Uchida

Surgery today Vol. 53 ( 5 ) page： 628 - 632 2023.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Rectal prolapse after radical surgery for anorectal malformations (ARMs) is a common postoperative complication that causes bleeding and stenosis, and sometimes requires surgical treatment. Different surgical techniques have been reported, but most are associated with high recurrence rates and a long postoperative stay. We performed the hemi-circumferential mucosal resection and anastomosis procedure (HCMR) to preserve anal muscle and anal function. Here, we report the success of our minimally invasive surgical approach to correct rectal prolapse in patients with ARMs. METHODS: The subjects of this retrospective review were patients who underwent HCMR for rectal prolapse after radical surgery for ARMs between January, 2014 and August, 2021. HCMR involves rectal mucosal resection without muscle plication. RESULTS: A collective 15 HCMR procedures were performed in 10 patients. The median age at repair was 1.8 years (range, 10 months-18 years). The median operation time and postoperative length of stay were 46 min (range, 17-85 min) and 3 days (range, 1-7 days), respectively. The median postoperative observation period was 3 years 4 months (range, 8 months-7 years 10 months) and no complications or recurrences were observed. CONCLUSIONS: HCMR is a safe and effective surgical treatment for rectal prolapse after radical operation for ARMs, which is minimally invasive and preserves rectal muscle and function.

DOI： 10.1007/s00595-022-02611-7

Web of Science

PubMed

Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis. Reviewed International journal

Kazuo Oshima, Akinari Hinoki, Hiroo Uchida, Yujiro Tanaka, Yusuke Okuno, Yasuhiro Go, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Aitaro Takimoto, Yoko Kano, Shinichiro Sawa

Pediatric surgery international Vol. 39 ( 1 ) page： 179 - 179 2023.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Necrotizing enterocolitis (NEC) causes fatal intestinal necrosis in neonates, but its etiology is unknown. We analyzed the intestinal immune response to NEC. METHODS: Using single-cell RNA sequencing (scRNA-seq), we analyzed the gene expression profiles of intestinal immune cells from four neonates with intestinal perforation (two with NEC and two without NEC). Target mononuclear cells were extracted from the lamina propria of the resected intestines. RESULTS: In all four cases, major immune cells, such as T cells (15.1-47.7%), B cells (3.1-19.0%), monocytes (16.5-31.2%), macrophages (1.6-17.4%), dendritic cells (2.4-12.2%), and natural killer cells (7.5-12.8%), were present in similar proportions to those in the neonatal cord blood. Gene set enrichment analysis showed that the MTOR, TNF-α, and MYC signaling pathways were enriched in T cells of the NEC patients, suggesting upregulated immune responses related to inflammation and cell proliferation. In addition, all four cases exhibited a bias toward cell-mediated inflammation, based on the predominance of T helper 1 cells. CONCLUSION: Intestinal immunity in NEC subjects exhibited stronger inflammatory responses compared to non-NEC subjects. Further scRNA-seq and cellular analysis may improve our understanding of the pathogenesis of NEC.

DOI： 10.1007/s00383-023-05461-7

Web of Science

PubMed

Novel urinary marker for diagnosis and prognosis of neuroblastoma Reviewed

Hiroo UCHIDA

Cancer Research Vol. 83 ( 7 ) 2023.4

Rare case of a right Bochdalek hernia with retroperitoneal prolapse of organs into the thoracic cavity in infancy: A case report. Reviewed

Yoichi Nakagawa, Hiroo Uchida, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Satoshi Makita, Hizuru Amano, Okamoto Masamune, Aitaro Takimoto, Seiya Ogata, Shunya Takada, Daiki Kato, Yousuke Gohda, Yaohui Guo

Asian journal of endoscopic surgery Vol. 16 ( 2 ) page： 284 - 288 2023.4

Language：English Publishing type：Research paper (scientific journal)

We report an extremely rare case of a right Bochdalek hernia with a sac, in which the retroperitoneal and intra-abdominal organs prolapsed into the thoracic cavity at the same time. The patient was a 7-month-old female with no comorbidities. She presented with cough and fever, and chest radiography revealed a right diaphragmatic hernia. Computed tomography showed that the right kidney, intestine, colon, and liver had prolapsed into the thoracic cavity. The patient underwent thoracoscopic surgery, which showed that the abdominal and retroperitoneal organs prolapsed into the thoracic cavity through the Bochdalek hernia. The herniated organs were spontaneously reduced using thoracoscopic insufflation. The defect hole was closed with artificial mesh. We adopted a thoracoscopic approach, in terms of easy reduction of herniated organs and accurate evaluation of the hernia orifice, which was useful.

DOI： 10.1111/ases.13139

Web of Science

PubMed

Editorial: Infants with cholestasis Reviewed

Uchida, H; Tiao, GM; Shivakumar, P; Wong, KKY; Asai, A; Amano, H

FRONTIERS IN PEDIATRICS Vol. 11 page： 1175231 2023.3

Update on aortopexy and posterior tracheopexy for tracheomalacia in patients with esophageal atresia Reviewed

Sumida, W; Yasui, A; Shirota, C; Makita, S; Okamoto, M; Ogata, S; Takimoto, A; Takada, S; Nakagawa, Y; Kato, D; Gohda, Y; Amano, H; Guo, YH; Hinoki, A; Uchida, H

SURGERY TODAY Vol. 54 ( 3 ) page： 211 - 219 2023.2

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Papers - UCHIDA Hiroo