Faculty Profiles - UCHIDA Hiroo

Papers - UCHIDA Hiroo

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Mechanisms of immunomodulation induced by blood transfusion: identification of humoral factors. Reviewed

Uchida H, Tanaka H, Kitoh Y, Yanagisawa K, To H, Tago K, Mizuta K, Fujimura A, Tominaga S, Hashizume K, Kobayashi E

Transplantation proceedings Vol. 32 ( 2 ) page： 255-6 2000.3

Mechanisms of immunomodulation induced by blood transfusion: Identification of humoral factors Reviewed

H Uchida, H Tanaka, Y Kitoh, K Yanagisawa, H To, K Tago, K Mizuta, A Fujimura, S Tominaga, K Hashizume, E Kobayashi

TRANSPLANTATION PROCEEDINGS Vol. 32 ( 2 ) page： 255 - 256 2000.3

プレドニゾロンの時間薬理学的研究 : 投与時刻による毒性および薬効の検討 Reviewed

冨沢直子, 小林英司, 内田広夫, 藤秀人, XIU Dian Rong, 藤村昭夫

臨床薬理 Vol. 31 ( 2 ) page： 261 - 262 2000.2

Hepatic lymphocyte transplantation in hyperbilirubinemic gunn rats. Reviewed

Yoshida Y, Kobayashi E, Nozawa M, Uchida H, Fujimura A, Yamanaka T, Miyata M

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes Vol. 32 ( 4 ) page： 223-7 2000

Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection. Reviewed

Kobayashi E, Lord R, Green M, Walker NI, Kamada N, Uchida H, Fujimura A

Transplantation proceedings Vol. 31 ( 8 ) page： 3409-13 1999.12

Detection of membrane-bound and soluble-form MHC class I antigen from rat pancreas/spleen grafts during ongoing rejection Reviewed

E Kobayashi, R Lord, M Green, NI Walker, N Kamada, H Uchida, A Fujimura

TRANSPLANTATION PROCEEDINGS Vol. 31 ( 8 ) page： 3409 - 3413 1999.12

Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion. Reviewed

Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

Chronobiology international Vol. 16 ( 6 ) page： 759-65 1999.11

Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile. Reviewed

Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A

Transplantation proceedings Vol. 31 ( 7 ) page： 2751-3 1999.11

Cyclosporine inhibits transport of bile acid in rats: comparison of bile acid composition between liver and bile. Reviewed

Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K

Transplantation proceedings Vol. 31 ( 7 ) page： 2755-6 1999.11

Chronotoxicity of mizoribine under repeated administration in the rat. Reviewed

Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A

Transplantation proceedings Vol. 31 ( 7 ) page： 2765-6 1999.11

Experimental intestinal transplantation using mouse fetal intestine in the rat: combination effect of FK 506 with cyclophosphamide. Reviewed

Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A

Transplantation proceedings Vol. 31 ( 7 ) page： 2799-800 1999.11

Experimental intestinal transplantation using mouse fetal intestine in the rat: Combination effect of FK 506 with cyclophosphamide Reviewed

Uchida H, Kobayashi E, Ogino Y, Mizuta K, Hashizume K, Fujimura A

TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page： 2799 - 2800 1999.11

Chronopharmacology of tacrolimus in rats: Toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile Reviewed

Uchida H, Kobayashi E, Ogino Y, Mizuta K, To H, Okabe R, Hashizume K, Fujimura A

TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page： 2751 - 2753 1999.11

Chronotoxicity of mizoribine under repeated administration in the rat Reviewed

Hishikawa S, To H, Kobayashi E, Uchida H, Fujimura A

TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page： 2765 - 2766 1999.11

Cyclosporine inhibits transport of bile acid in rats: Comparison of bile acid composition between liver and bile Reviewed

Mizuta K, Kobayashi E, Uchida H, Ogino Y, Fujimura A, Kawarasaki H, Hashizume K

TRANSPLANTATION PROCEEDINGS Vol. 31 ( 7 ) page： 2755 - 2756 1999.11

Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model - Comparative study with cyclosporine Reviewed International journal

K Mizuta, E Kobayashi, H Uchida, A Fujimura, H Kawarasaki, K Hashizume

TRANSPLANT INTERNATIONAL Vol. 12 ( 5 ) page： 316 - 322 1999.10

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER VERLAG

Cholestatic effects have been reported for cyclosporine (CsA), but information is still limited for tacrolimus (TCR). The purpose of this study was to investigate the influence of TCR on biliary bile acid and lipid composition as compared with CsA, using a continuously bile-drained rat model. Adult male Wistar rats received TCR (0.4 mg/kg, 1 mg/kg, and 4 mg/kg) or CsA (2.5 mg/kg, 10 mg/kg, and 25 mg/kg) by intramuscular injection (i.m.) daily for 10 days,On day 7, the common bile duct of all rats was cannulated, then bile was continuously collected for the following 3 days. Bile flow, bile acid secretion rate (BASR), and biliary lipids secretion were measured for each of the groups. TCR increased bile acid-dependent flow (BADF) but with no statistical significance. However this agent did not influence total bile flow and biliary lipids secretion, while bile acid-independent flow (BAIF) was significantly reduced and bile acid synthesis (mainly cholic acid, CA, synthesis) was increased. In contrast, CsA was cholestatic, showing a tendency to reduce both BADF and BAIF. BASR was dose-dependently suppressed, especially in chenodeoxycholic acid (CDCA). Furthermore biliary lipids secretions were also significantly decreased under a higher dose of CsA, TCR increased BADF with no influence on total bile Row, having a stimulating effect on CA production, although CsA dose-dependently diminishes CDCA production and consequently reduced bile secretion. Our results suggest that TCR is a less effective agent on cholestasis as compared to CsA.

DOI： 10.1111/j.1432-2277.1999.tb00616.x

Web of Science

Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor. Reviewed

Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K

Journal of pediatric surgery Vol. 34 ( 9 ) page： 1396-400 1999.9

Experimental small bowel transplantation using newborn intestine in rats: II. Revascularization of newborn intestine is independent of vascular endothelial growth factor Reviewed

Uchida H, Kobayashi E, Yanagisawa K, Mizuta K, Kitoh Y, Fujimura A, Tominaga S, Kawarasaki H, Hashizume K

JOURNAL OF PEDIATRIC SURGERY Vol. 34 ( 9 ) page： 1396 - 1400 1999.9

Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft. Reviewed

Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K

Journal of pediatric surgery Vol. 34 ( 6 ) page： 1007-11 1999.6

Experimental small bowel transplantation using newborn intestine in rats: I. Lipid absorption restored after transplantation of nonvascularized graft Reviewed

Uchida H, Yoshida T, Kobayashi E, Mizuta K, Fujimura A, Miyata M, Kawarasaki H, Hashizume K

JOURNAL OF PEDIATRIC SURGERY Vol. 34 ( 6 ) page： 1007 - 1011 1999.6

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