Faculty Profiles - UCHIDA Hiroo

Papers - UCHIDA Hiroo

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Chronopharmacology for deoxyspergualin: toxicity and efficacy in the rat. Reviewed

Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

Transplantation Vol. 67 ( 9 ) page： 1269-74 1999.5

Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed

Uchida H, Kobayashi E, Matsuda K, Mizuta K, Sugimoto K, Kawarasaki H, Hashizume K, Fujimura A

TRANSPLANTATION Vol. 67 ( 9 ) page： 1269 - 1274 1999.5

Chronopharmacology for deoxyspergualin - Toxicity and efficacy in the rat Reviewed International journal

H Uchida, E Kobayashi, K Matsuda, K Mizuta, K Sugimoto, H Kawarasaki, K Hashizume, A Fujimura

TRANSPLANTATION Vol. 67 ( 9 ) page： 1269 - 1274 1999.5

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Background Deoxyspergualin (DSG), a potent immunosuppressive drug, has been clinically used as a rescue therapy for acute graft rejection. However, DSG has severe adverse effects that limits its use. Here, we examined the optimized therapeutic protocol for DSG using chronopharmacological profiles of it.
Methods. First, a dosing time-dependent difference in the toxicity and efficacy of DSG was determined using a heterotopic heart transplantation model. Second, chronokinetics of DSG were examined to reveal the mechanism for dosing time-dependent differences in the effect.
Results. In rats treated with DSG at the active period, bone marrow suppression and damage of small intestine were significantly severe. However, no significant difference was found in cardiac allograft survival and pharmacokinetics according to the timing of drug administration.
Conclusions. The toxicity of DSG varied with the dosing time, whereas its efficacy did not. The chronopharmacological approach may provide merits for immunosuppressive therapy with DSG in clinical organ transplantation.

DOI： 10.1097/00007890-199905150-00012

Web of Science

Scopus

Other Link： http://orcid.org/0000-0002-1818-6697

Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model. Comparative study with cyclosporine. Reviewed

Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

Transplant international : official journal of the European Society for Organ Transplantation Vol. 12 ( 5 ) page： 316-22 1999

Effect of immunosuppressants on bile acid kinetics - Comparative study of cyclosporine with tacrolimus Reviewed International journal

Mizuta, K., Kawarasaki, H., Hashizume, K., Fujimura, A., Uchida, H., Kobayashi, E.

Japanese Pharmacology and Therapeutics Vol. 27 ( SUPPL. 7 ) page： 93 - 98 1999

Mechanism of neovascularization in rat newborn organs - Expression of VEGF mRNA and effect of TNP-470 on graft survival Reviewed International journal

Uchida, H., Kobayashi, E., Yanagisawa, K., Mizuta, K., Tominaga, S.-I., Hashizume, K., Fujimura, A.

Biotherapy Vol. 13 ( 5 ) page： 439 - 441 1999

Survival of rats undergoing continuous bile drainage depends on maintenance of circadian rhythm of bile secretion Reviewed

Mizuta K, Hishikawa S, Yoshida T, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

CHRONOBIOLOGY INTERNATIONAL Vol. 16 ( 6 ) page： 759 - 765 1999

Experimental small bowel transplantation using newborn intestine in rats - Some immunological studies and considerations for immunological advantage Reviewed

T Yoshida, H Uchida, E Kobayashi, A Fujimura, M Miyata

JAPANESE JOURNAL OF TRANSPLANTATION Vol. 34 ( 4 ) page： 165 - 173 1999

Do immunosuppressants directly affect neutrophils, resulting in protection of the liver against ischemia-reperfusion injury? Reviewed

Ohmori M, Kobayashi E, Harada K, Kitoh Y, Mizuta K, Uchida H, Ogino Y, Fujimura A

Transplantation Vol. 66 ( 7 ) page： 940-1 1998.10

Dose-dependent reduction of bile secretion in cyclosporine-treated rats. Reviewed

Mizuta K, Kobayashi E, Uchida H, Fujimura A, Kawarasaki H, Hashizume K

Transplantation Vol. 65 ( 5 ) page： 758-9 1998.3

Antenatal diagnosis of biliary atresia (type I cyst) at 19 weeks' gestation: differential diagnosis and etiologic implications. Reviewed

Tsuchida Y, Kawarasaki H, Iwanaka T, Uchida H, Nakanishi H, Uno K

Journal of pediatric surgery Vol. 30 ( 5 ) page： 697-9 1995.5

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