Faculty Profiles - UCHIDA Hiroo

Papers - UCHIDA Hiroo

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Thoracoscopic primary repair is useful for esophageal atresia with tracheoesophageal fistula in neonates with low body weight. Reviewed International journal

Yousuke Gohda, Hiroo Uchida, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Miwa Satomi, Akihiro Yasui, Yoko Kanou, Yoichi Nakagawa, Daiki Kato, Takuya Maeda, Yaohui Guo, Jiahui Liu, Hiroki Ishii, Kazuki Ota, Akinari Hinoki

Pediatric surgery international Vol. 40 ( 1 ) page： 149 - 149 2024.6

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The surgical indication of thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula is under debate. The current study aimed to investigate the outcome of thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula in patients weighing < 2000 g and those who underwent emergency surgery at the age of 0 day. METHODS: The surgical outcomes were compared between patients weighing < 2000 g and those weighing > 2000 g at surgery and between patients who underwent surgery at the age of 0 day and those who underwent surgery at age ≥ 1 day. RESULTS: In total, 43 patients underwent thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula. The surgical outcomes according to body weight were similar. Patients who underwent surgery at the age of 0 day were more likely to develop anastomotic leakage than those who underwent surgery at the age of ≥ 1 day (2 vs. 0 case, p = 0.02). Anastomotic leakage was treated with conservative therapy. CONCLUSION: Thoracoscopic primary repair is safe and useful for esophageal atresia with tracheoesophageal fistula even in newborns weighing < 2000 g. However, emergency surgery at the age of 0 day should be cautiously performed due to the risk of anastomotic leakage.

DOI： 10.1007/s00383-024-05724-x

Scopus

PubMed

新専門医制度におけるサブスペシャルティ小児外科領域の現状施設認定委員会より Reviewed

木下義晶, 浮山越史, 文野誠久, 田中潔, 米田光宏, 佐々木英之, 内田広夫, 古村眞, 石丸哲也, 大久保龍二, 家入里志, 小野滋, 日本小児外科学会専門医制度委員会

日本小児外科学会雑誌 Vol. 60 ( 3 ) page： 374 - 374 2024.4

Duodenal duplication cyst at the second part of the duodenum with congenital duodenal position anomaly completely resected by laparoscopic partial duodenectomy: a case report. Reviewed International journal

Yoichi Nakagawa, Hiroo Uchida, Satoshi Makita, Takahisa Tainaka, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Hizuru Amano, Akihiro Yasui, Yoko Kano, Takuya Maeda, Daiki Kato, Yousuke Gohda

Surgical case reports Vol. 10 ( 1 ) page： 73 - 73 2024.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Duodenal duplication cysts (DDC) are rare duplications of the alimentary tract. Their treatment depends on their size and location. A radical treatment is total resection, if possible. However, partial excision, puncture, and marsupialization can be selected to prevent surgical injury to the pancreaticobiliary tract despite the risk of recurrence. There are some reports of pancreaticoduodenectomy for DDC because of the risk of recurrent symptoms and malignancy. However, this is considered excessively invasive for DDC, particularly in pediatric cases, because of its extremely low rate of malignancy and high morbidity and mortality rates. We encountered a case of DDC with a congenital duodenal position anomaly occurring in the second part of the duodenum. Taking advantage of the congenital duodenal position anomaly, the DDC was completely resected without injuring the pancreaticobiliary duct. CASE PRESENTATION: A 6-year-old boy was diagnosed with a duodenal duplication cyst with obstruction. There was a congenital duodenal position anomaly. The distal second part of the duodenum was the dorsal side of the proximal second part of the duodenum and ascended upward from the proximal second part of the duodenum. The third and fourth parts of the duodenum ran downward to the left and posterior parts of the portal vein, forming the ligament of Treitz. Complete laparoscopic resection of the duodenal duplication cyst and the second to fourth parts of the duodenum, and duodenojejunostomy with retrocolic reconstruction was performed because the duodenum was easily mobilized to the ligament of Treitz owing to the duodenal position anomaly. The duodenojejunostomy with retrocolic reconstruction achieved a more physiologically normal appearance compared to what would have been achieved with a Roux-en-Y reconstruction. The patient was discharged on postoperative day 12 without any complications. CONCLUSIONS: The procedure used in this case might not be easily applied in all laparoscopy cases. However, it could be an option for duodenal duplication cysts with congenital duodenal position anomalies.

DOI： 10.1186/s40792-024-01875-0

Web of Science

PubMed

A systematic review of Sandifer syndrome in children with severe gastroesophageal reflux. Reviewed

Kato D, Uchida H, Amano H, Yokota K, Shirota C, Tainaka T, Sumida W, Makita S, Yasui A, Gohda Y, Maeda T, Hinoki A

Pediatric surgery international Vol. 40 ( 1 ) page： 91 2024.3

Surgical Strategies for Neonates with Prenatally Diagnosed Congenital Biliary Dilatation. Reviewed

Shirota C, Hinoki A, Tainaka T, Sumida W, Makita S, Amano H, Takimoto A, Yasui A, Nakagawa Y, Liu J, Guo Y, Kato D, Goda Y, Maeda T, Uchida H

Journal of pediatric surgery Vol. 59 ( 3 ) page： 385 - 388 2024.3

Scoring system for diagnosis and pretreatment risk assessment of neuroblastoma using urinary biomarker combinations. Reviewed International journal

Hizuru Amano, Hiroo Uchida, Kazuharu Harada, Atsushi Narita, Shigehisa Fumino, Yuji Yamada, Shun Kumano, Mayumi Abe, Takashi Ishigaki, Minoru Sakairi, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Satoshi Makita, Shuhei Karakawa, Yuichi Mitani, Shojiro Matsumoto, Yutaka Tomioka, Hideki Muramatsu, Nobuhiro Nishio, Tsuyoshi Osawa, Masataka Taguri, Katsuyoshi Koh, Tatsuro Tajiri, Motohiro Kato, Kimikazu Matsumoto, Yoshiyuki Takahashi, Akinari Hinoki

Cancer science 2024.2

Language：English Publishing type：Research paper (scientific journal)

The urinary catecholamine metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA), are used for the adjunctive diagnosis of neuroblastomas. We aimed to develop a scoring system for the diagnosis and pretreatment risk assessment of neuroblastoma, incorporating age and other urinary catecholamine metabolite combinations. Urine samples from 227 controls (227 samples) and 68 patients with neuroblastoma (228 samples) were evaluated. First, the catecholamine metabolites vanillactic acid (VLA) and 3-methoxytyramine sulfate (MTS) were identified as urinary marker candidates through comprehensive analysis using liquid chromatography-mass spectrometry. The concentrations of these marker candidates and conventional markers were then compared among controls, patients, and numerous risk groups to develop a scoring system. Participants were classified into four groups: control, low risk, intermediate risk, and high risk, and the proportional odds model was fitted using the L2-penalized maximum likelihood method, incorporating age on a monthly scale for adjustment. This scoring model using the novel urine catecholamine metabolite combinations, VLA and MTS, had greater area under the curve values than the model using HVA and VMA for diagnosis (0.978 vs. 0.964), pretreatment risk assessment (low and intermediate risk vs. high risk: 0.866 vs. 0.724; low risk vs. intermediate and high risk: 0.871 vs. 0.680), and prognostic factors (MYCN status: 0.741 vs. 0.369, histology: 0.932 vs. 0.747). The new system also had greater accuracy in detecting missing high-risk neuroblastomas, and in predicting the pretreatment risk at the time of screening. The new scoring system employing VLA and MTS has the potential to replace the conventional adjunctive diagnostic method using HVA and VMA.

DOI： 10.1111/cas.16116

PubMed

特集胆道閉鎖症の研究update 胆道閉鎖症診療ガイドラインの改訂に向けて Reviewed

仁尾正記, 虻川大樹, 内田広夫, 黒田達夫, 鈴木達也, 山髙篤行, 吉田雅博, 和田基, 佐々木英之, 大久保龍二

小児外科 Vol. 56 ( 2 ) page： 170 - 173 2024.2

Laparoscopic Fundoplication in Patients with Ventriculoperitoneal Shunts: A Systematic Review and Our Experience Reviewed

Kato, D; Uchida, H; Tainaka, T; Amano, H; Ono, Y; Yasui, A; Shirota, C; Sumida, W; Yokota, K; Makita, S; Takimoto, A; Takada, S; Nakagawa, Y; Gohda, Y; Maeda, T; Hinoki, A

JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES Vol. 34 ( 3 ) page： 268 - 273 2024.1

M U-Net: Intestine Segmentation Using Multi-dimensional Features for Ileus Diagnosis Assistance Reviewed

Qin An, Hirohisa Oda, Yuichiro Hayashi, Takayuki Kitasaka, Akinari Hinoki, Hiroo Uchida, Kojiro Suzuki, Aitaro Takimoto, Masahiro Oda, Kensaku Mori

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) Vol. 14313 page： 135 - 144 2024

Language：English Publishing type：Research paper (international conference proceedings)

The intestine is an essential digestive organ that can cause serious health problems once diseased. This paper proposes a method for intestine segmentation to intestine obstruction diagnosis assistance called multi-dimensional U-Net (M U-Net). We employ two encoders to extract features from two-dimensional (2D) CT slices and three-dimensional (3D) CT patches. These two encoders collaborate to enhance the segmentation accuracy of the model. Additionally, we incorporate deep supervision with the M U-Net to reduce the limitation of training with sparse label data sets. The experimental results demonstrated that the Dice of the proposed method was 73.22%, the recall was 79.89%, and the precision was 70.61%.

DOI： 10.1007/978-3-031-47076-9_14

Web of Science

Scopus

食道閉鎖症に対する治療戦略：私達はなぜ胸腔鏡手術を選択するのか Reviewed

内田広夫, 田井中貴久, 城田千代栄, 住田亙, 牧田智, 横田一樹, 安井昭洋, 高田瞬也, 中川洋一, 前田拓也, 加藤大幾, 合田陽祐, 郭垚輝, 劉佳慧

日本周産期・新生児医学会雑誌 Vol. 59 ( 4 ) page： 470 - 474 2024

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本周産期・新生児医学会

<p>　はじめに</p><p>　名古屋大学小児外科では，食道閉鎖症に対して胸腔鏡下根治術を第一選択としている．アメリカでの現状，meta-analysisに触れながら，当院の治療戦略について簡単に述べる．</p>

DOI： 10.34456/jjspnm.59.4_470

CiNii Research

当院におけるロボット支援腹腔鏡下胆道拡張症手術について Reviewed

田井中貴久, 城田千代栄, 牧田智, 里見美和, 狩野陽子, 安井昭和, 中川洋一, 加藤大幾, 前田拓也, 石井宏樹, 太田和樹, 天野日出, 檜顕成, 内田広夫

日本膵・胆管合流異常研究会プロシーディングス Vol. 47 ( 0 ) page： 62 - 63 2024

Intestine Segmentation from CT Volume based on Bidirectional Teaching Reviewed

An, Q; Oda, H; Hayashi, Y; Kitasaka, T; Hinoki, A; Uchida, H; Suzuki, K; Takimoto, A; Oda, M; Mori, K

MEDICAL IMAGING 2024: IMAGE PROCESSING Vol. 12926 2024

10kg 未満の患者に対してもロボット支援腹腔鏡下先天性胆道拡張症手術は安全に行える Reviewed

石井宏樹, 内田広夫, 城田千代栄, 田井中貴久, 牧田智, 里見美和, 安井昭洋, 中川洋一, 加藤大幾, 前田拓也, 太田和樹

日本膵・胆管合流異常研究会プロシーディングス Vol. 47 ( 0 ) page： 66 - 66 2024

DDS-type near-infrared light absorber enables deeper lesion treatment in laser photothermal therapy while avoiding damage to surrounding organs. Reviewed International journal

Masataka Takahashi, Jun Fujishiro, Shinsuke Nomura, Manabu Harada, Akinari Hinoki, Masashi Arake, Eiichi Ozeki, Isao Hara, Ayano Satoh, Takahisa Tainaka, Hiro-O Uchida, Yuji Morimoto

Frontiers in bioengineering and biotechnology Vol. 12 page： 1444107 - 1444107 2024

Language：English Publishing type：Research paper (scientific journal)

The efficacy of drug delivery system (DDS)-type near-infrared (NIR) absorbing agents in enhancing laser photothermal therapy is widely acknowledged. Despite the acknowledged efficacy, the therapeutic advantages of photothermal therapy using DDS-type NIR-absorbing agents over simple photothermal therapy without such agents have not been fully elucidated. This study was designed to investigate two primary objectives: firstly, the ability of DDS-type NIR-absorbing agents to induce cell death at greater depths within tumors, and secondly, their capacity to minimize collateral damage to adjacent healthy organs. To investigate these objectives, we employed a combination of indocyanine green lactosome-a DDS-type NIR-absorbing agent-and a precision-controlled laser hyperthermia system. An orthotopic neuroblastoma tumor model was used to closely simulate clinical conditions. The findings revealed that photothermal therapy using the DDS-type NIR-absorbing agent not only facilitates deeper penetration of cell death within tumors but also significantly mitigates thermal damage to surrounding healthy tissues, when compared to simple phototherapy without the agent. Furthermore, the combined treatment significantly prolonged the survival periods of the animals involved. This study is the first to analyze these therapeutic efficacies using quantitative data from an orthotopic tumor animal model and substantiated the potential of DDS-type NIR-absorbing agents to deepen the therapeutic impact of photothermal therapy while safeguarding vital organs, thereby enhancing overall treatment outcomes.

DOI： 10.3389/fbioe.2024.1444107

PubMed

HTSeg: Hybrid Two-Stage Segmentation Framework for Intestine Segmentation from CT Volumes Reviewed

Hiroo UCHIDA

Lecture Notes in Computer Science Vol. 15196 page： 32 - 41 2024

Anastomotic time was associated with postoperative complications: a cumulative sum analysis of thoracoscopic repair of tracheoesophageal fistula in a single surgeon's experience. Reviewed

Yaohui Guo, Akinari Hinoki, Kyoichi Deie, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Masamune Okamoto, Aitarou Takimoto, Akihiro Yasui, Shunya Takada, Yoichi Nakagawa, Daiki Kato, Takuya Maeda, Hizuru Amano, Hiroshi Kawashima, Hiroo Uchida, Chiyoe Shirota

Surgery today Vol. 53 ( 12 ) page： 1363 - 1371 2023.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study aimed to evaluate the learning curve of thoracoscopic repair of tracheoesophageal fistula (TEF) by a single surgeon using a cumulative sum (CUSUM) analysis. METHODS: Prospective clinical data of consecutive Gross type-C TEF repairs performed by a pediatric surgeon from 2010 to 2020 were recorded. CUSUM charts for anastomosis and operating times were generated. The learning curves were compared with the effect of accumulation based on case experience. RESULTS: For 33 consecutive cases, the mean operative and anastomosis times were 139 ± 39 min and 3137 ± 1110 s, respectively. Significant transitions beyond the learning phase for total operating and anastomosis times were observed at cases 13 and 17. Both the total operating time and anastomosis time were significantly faster in the proficiency improvement phase than in the initial learning phase. Postoperative complications significantly decreased after the initial anastomosis learning phase but not after the initial total operating learning phase. CONCLUSIONS: Thoracoscopic repair of TEF is considered safe and feasible after 13 cases, where the surgeon can improve their proficiency with the total operation procedure, and 17 cases, which will enable the surgeon to achieve proficiency in anastomosis. Postoperative complications significantly decreased after gaining familiarity with the anastomosis procedure through the learning phase.

DOI： 10.1007/s00595-023-02687-9

Web of Science

PubMed

Application of indocyanine green fluorescence imaging navigation in pediatric surgery: A single-center review Reviewed

Hiroo UCHIDA

Journal of Pediatric Surgery Open Vol. 4 2023.12

Preoperative management comprising tube irrigation using a trans-anal indwelling tube for infants with hirschsprung disease can allow single-stage radical surgery. Reviewed International journal

Nakagawa Y, Uchida H, Hinoki A, Tainaka T, Shirota C, Sumida W, Makita S, Yokota K, Amano H, Yasui A, Maeda T, Kato D, Gohda Y

BMC SURGERY Vol. 23 ( 1 ) page： 333 2023.11

Variations of the hepatic artery and bile duct in patients with pancreaticobiliary maljunction: Impact on postoperative outcomes Reviewed

Takada, S; Uchida, H; Hinoki, A; Shirota, C; Sumida, W; Tainaka, T; Makita, S; Takimoto, A; Nakagawa, Y; Maeda, T

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES Vol. 30 ( 11 ) page： 1241 - 1248 2023.11

A new criterion including the aspartate aminotransferase-to-platelet ratio index and liver and spleen stiffness to rule out varices needing treatment in children with biliary atresia: Modification of the Baveno VII criteria. Reviewed International journal

Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Hisanori Muto, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Shunya Takada, Yoichi Nakagawa, Takuya Maeda, Masanao Nakamura, Masatoshi Ishigami, Hiroo Uchida, Hiroki Kawashima

Hepatology research : the official journal of the Japan Society of Hepatology 2023.10

Language：English Publishing type：Research paper (scientific journal)

AIMS: Biliary atresia (BA) is a congestive biliary disease that develops in the neonatal period or early infancy. It may present with portal hypertension and varices needing treatment (VNT) even after successful Kasai portoenterostomy. This study aimed to stratify the risk of VNT in children and adolescents with BA. METHODS: In this prospective cross-sectional study, we measured liver stiffness (LS) and spleen stiffness (SS) by two-dimensional shear wave elastography and checked for VNT endoscopically in 53 patients with BA who attended for follow-up between July 2018 and September 2022. Varices needing treatment were defined as large esophageal varices, esophageal varices of any size with red color signs, and/or gastric varices along the cardia. RESULTS: Twenty-five patients (aged 0-18 years) had VNT. Eighteen patients met the Baveno VI criteria (LS <20 kPa; platelet count >150 000/L) and were deemed to be at low risk of VNT (spared endoscopies) while three had missed VNT (16.7%). Applying the Baveno VII criteria, which combines the SS cut-off value of 40 kPa with the Baveno VI criteria, resulted in five missed VNTs among 22 spared endoscopies (22.7%). A modification of the Baveno VII criteria using the aspartate aminotransferase-to-platelet ratio index (APRI) instead of the platelet count with cut-off values of 25 kPa, 30 kPa, and 1.04 for LS, SS, and APRI, respectively, missed only one VNT (5.0%) among 20 spared endoscopies. CONCLUSIONS: A novel diagnostic criterion that combines LS, SS, and APRI reduced the risk of missing VNT to 5% in children and adolescents with BA.

DOI： 10.1111/hepr.13976

PubMed

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Papers - UCHIDA Hiroo