Faculty Profiles - NISHIDA, Yoshihiro

Papers - NISHIDA, Yoshihiro

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A case of retroperitoneal dedifferentiated liposarcoma successfully treated by neoadjuvant chemotherapy and subsequent surgery. Reviewed Open Access

Yokoyama Y, Nishida Y, Ikuta K, Nagino M

Surgical case reports Vol. 6 ( 1 ) page： 105 2020.5

Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors. Reviewed

Nishida, Y; Urakawa, H; Nakayama, R; Ozaki, T; Ae, K; Matsumoto, Y; Ando, Y; Kuwatsuka, Y; Ueda, T; Kawai, A

JOURNAL OF CLINICAL ONCOLOGY Vol. 38 ( 15 ) 2020.5

Results of a randomized phase II/III study comparing perioperative adriamycin plus ifosfamide and gemcitabine plus docetaxel for high-grade soft tissue sarcomas: Japan Clinical Oncology Group study JCOG1306. Reviewed

Tanaka, K; Machida, R; Kawai, A; Nakayama, R; Tsukushi, S; Asanuma, K; Matsumoto, Y; Hiraga, H; Hiraoka, K; Watanuki, M; Yonemoto, T; Abe, S; Katagiri, H; Nishida, Y; Nagano, A; Suehara, Y; Kataoka, T; Fukuda, H; Ozaki, T; Iwamoto, Y

JOURNAL OF CLINICAL ONCOLOGY Vol. 38 ( 15 ) 2020.5

Type II Respiratory Failure with Systemic Sclerosis/Polymyositis Overlap Syndrome：A Case Report of Successful Respiratory Rehabilitation Therapy

Okada Takashi, Nishida Yoshihiro, Hishida Aika, Sugiyama Junya, Kadono Izumi, Sugiura Hideshi, Konno Suzuna

The Japanese Journal of Rehabilitation Medicine Vol. 57 ( 5 ) page： 468 - 473 2020.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association of Rehabilitation Medicine

Introduction：Respiratory failures are categorized into types I and II. To our knowledge, we report the first case of pulmonary rehabilitation in a patient with systemic sclerosis/polymyositis overlap syndrome who developed type II respiratory failure.Methods：The patient was a 77-year-old woman who had received treatment for systemic sclerosis and polymyositis at another hospital. When she visited our hospital to obtain a second opinion, she suddenly lost consciousness and underwent trachea intubation because of typeⅡrespiratory failure. She received physical therapy on the third day of hospitalization and underwent a tracheotomy on the 16th day. As her thoracic movement was markedly restricted, we started physical training. After she was weaned off from the ventilator on the 43rd day, we performed muscular strength training and aerobic exercise. No exacerbation of CO2 storage was observed even if chest motion training was performed. She was discharged on the 72nd day and advised to wear retina®．Administration of therapeutic drugs such as steroids was maintained at the same dose.Conclusion：Physical therapy, such as chest mobilization, was effective for marked restriction of chest movement in a patient who had both polymyositis and systemic sclerosis.

DOI： 10.2490/jjrmc.18038

CiNii Research

Thoracic dumbbell-shaped paraganglioma arising in extra-adrenal area: A case report and literature review. Reviewed

Tsushima M, Imagama S, Ando K, Kobayashi K, Ito K, Matsumoto A, Nishida Y, Ishiguro N

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Vol. 25 ( 3 ) page： 525 - 528 2020.5

Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments Reviewed

Sassa, N; Yokoyama, Y; Nishida, Y; Yamada, S; Uchida, H; Kajiyama, H; Nagino, M; Kodera, Y; Gotoh, M

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 5 ) page： 929 - 936 2020.5

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Clinical Oncology

Background: There are only a limited number of comprehensive reports for retroperitoneal tumors (RPTs). The aim of this study was to perform an interdepartmental data collection for RPTs and to comprehensively clarify the clinical characteristics of this rare disease. Methods: All patients who were diagnosed with RPT from January 2005 to July 2018 in a single institution were included. The analyzed factors included demographics, clinical features, treatment methods, pathological diagnosis, and prognosis. Results: A total of 422 patients (215 males and 207 females) with primary RPTs were identified. Biopsy for RPT was performed in 180 patients (43%). Among the 422 patients, 239 (57%) underwent surgery. The most common tissue origin was mesodermal (n = 99, 41%), followed by neurogenic (n = 54, 23%), extragonadal (n = 27, 11%), and metastatic tumors (n = 13, 5%). Among the 99 resected mesodermal tumors, the most common pathological subtypes were liposarcoma (n = 55, 56%) and leiomyosarcoma (n = 16, 16%). The long-term outcomes after surgery were analyzed in patients with intermediate and malignant sarcomas (including liposarcoma, leiomyosarcoma, and others combined, n = 71). The 3- and 5-year disease-free survival rates in the intermediate tumors were 68.2% and 54.2%, respectively, whereas those in the malignant tumors were 48.6% and 28.9%, respectively. The 3- and 5-year overall survival rates in the intermediate tumors were 100% and 94.1%, respectively, whereas those in the malignant tumors were 78.4% and 72.8%, respectively (p = 0.009). Conclusions: The clinical manifestations of RPTs were extremely variable. Recurrence after repeating resection is commonly observed in patients with malignant retroperitoneal sarcoma.

DOI： 10.1007/s10147-020-01620-1

Web of Science

Scopus

PubMed

症例報告上腕骨近位部の骨表面に発生したグロムス腫瘍の1例 Reviewed

生田国大, 新井英介, 杉浦喬也, 酒井智久, 小池宏, 西田佳弘

臨床整形外科 Vol. 55 ( 4 ) page： 385 - 388 2020.4

The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients. Reviewed Open Access

Desmoid Tumor Working Group. (Alman B, Nishida Y, et al)

Eur J Cancer. Vol. 127 page： 96 - 107 2020.3

The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma Reviewed Open Access

Heng, M; Gupta, A; Chung, PW; Healey, JH; Vaynrub, M; Rose, PS; Houdek, MT; Lin, PP; Bishop, AJ; Hornicek, FJ; Chen, YL; Lozano-Calderon, S; Holt, GE; Han, I; Biau, D; Niu, XH; Bernthal, NM; Ferguson, PC; Wunder, JS; Ueda, T; Kakunaga, S; Kawai, A; Sugiura, H; Kidani, T; Kunisasa, T; Ozaki, T; Ae, K; Nagano, A; Ohno, T; Hiraoka, K; Yamamoto, N; Tsuchiya, H; Matsumoto, Y; Yanagawa, T; Nakayama, R; Morioka, H; Kubo, T; Simose, S; Yamagami, Y; Yamamoto, T; Kawasaki, M; Torigoe, T; Yazawa, Y; Akiyama, T; Gokita, T; Manabe, J; Kaya, M; Emori, M; Nakamura, T; Matsumine, A; Sugihara, S; Yokouchi, M; Komiya, S; Suehara, Y; Takagi, T; Kawamoto, T; Wasa, J; Yonemoto, T; Ishii, T; Baba, I; Hoshi, M; Hamada, K; Naka, N; Sotobori, T; Araki, N; Okuma, T; Goto, T; Kobayashi, H; Kawano, H; Hosaka, M; Futani, H; Hiraga, H; Nishida, Y; Griffin, A; Razak, ARA; Shultz, DB; Catton, C; Robinson, S; Patel, SR; Lewis, VO; Guadagnolo, BA; DeLaney, T; Wang, HT; Raskin, K; Callan, AK; Henshaw, R; Isler, M; Mottard, S; Chen, WM; Traub, F; Chen, TWW; Turcotte, RE; Davidson, D; Tunn, PU; Loong, H; Ghert, M; Werier, J; Clarkson, P; Abraham, JA

EUROPEAN JOURNAL OF CANCER Vol. 125 page： 130 - 141 2020.1

食道癌術後の心房細動発症が術後経過、身体機能に及ぼす影響 Reviewed

白井祐也, 水野陽太, 清水大, 井上貴行, 岡田貴士, 西田佳弘, 小池聖彦, 永谷元基

理学療法学Supplement Vol. 47S1 ( 0 ) page： C-17_2 - C-17_2 2020

筋力低下に加え、廃用も呈した抗SRP（signal recognition particle）抗体陽性壊死性ミオパチー症例に対する理学療法介入の経験 Reviewed

鄭伃廷, 加古誠人, 柴田篤志, 天草善信, 橋詰淳, 熱田直樹, 勝野雅央, 西田佳弘

理学療法学Supplement Vol. 47S1 ( 0 ) page： F-171_2 - F-171_2 2020

Diagnosis, treatment, and proposal of the new classification system for the severity of desmoid tumors associated with familial adenomatous polyposis Reviewed

Mori Yoshiko, Chikatani Kenichi, Ishida Hideyuki, Yamano Tomoki, Momose Syuji, Tomita Naohiro, Osada Hisato, Nuguruma Naoki, Takayama Tetsuji, Akiyama Yasuki, Hirata Keiji, Nishida Yoshihiro, Ishikawa Hideki

Journal of Hereditary Tumors Vol. 20 ( 2 ) page： 45 - 58 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for Hereditary Tumors

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder characterized by multiple colorectal adenomas. Desmoid tumors (DT) are a well-known extracolonic manifestation of FAP that frequently develop in the mesentery, retroperitoneum, and/or abdominal wall in patients
with FAP. DT negatively impact the quality of life and affect survival. Due to their unclear natural course and insufficient data, there is no established evidencebased medical treatment for DT. In this article, we describe the diagnosis and treatment for DT in patients with FAP, and propose a classification system for the severity of FAP-related DT, with the aim of establishing a standard treatment for this condition.

DOI： 10.18976/jsht.20.2_45

CiNii Research

大腿部骨・軟部腫瘍患者における患肢温存術後の機能変化に関する報告 Reviewed

栢本あずさ, 加古誠人, 西田佳弘

理学療法学Supplement Vol. 47S1 ( 0 ) page： A-206_1 - A-206_1 2020

【治療選択誌上ディベート（第20回）】デスモイドの治療選択保存治療VS手術　保存治療の立場から Reviewed

西田佳弘

Loco Cure Vol. 6 page： 68 - 71 2020

Integrated exome and RNA sequencing of dedifferentiated liposarcoma Reviewed Open Access

Hirata, M; Asano, N; Katayama, K; Yoshida, A; Tsuda, Y; Sekimizu, M; Mitani, S; Kobayashi, E; Komiyama, M; Fujimoto, H; Goto, T; Iwamoto, Y; Naka, N; Iwata, S; Nishida, Y; Hiruma, T; Hiraga, H; Kawano, H; Motoi, T; Oda, Y; Matsubara, D; Fujita, M; Shibata, T; Nakagawa, H; Nakayama, R; Kondo, T; Imoto, S; Miyano, S; Kawai, A; Yamaguchi, R; Ichikawa, H; Matsuda, K

NATURE COMMUNICATIONS Vol. 10 ( 1 ) page： 5683 2019.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Communications

The genomic characteristics of dedifferentiated liposarcoma (DDLPS) that are associated with clinical features remain to be identified. Here, we conduct integrated whole exome and RNA sequencing analysis in 115 DDLPS tumors and perform comparative genomic analysis of well-differentiated and dedifferentiated components from eight DDLPS samples. Several somatic copy-number alterations (SCNAs), including the gain of 12q15, are identified as frequent genomic alterations. CTDSP1/2-DNM3OS fusion genes are identified in a subset of DDLPS tumors. Based on the association of SCNAs with clinical features, the DDLPS tumors are clustered into three groups. This clustering can predict the clinical outcome independently. The comparative analysis between well-differentiated and dedifferentiated components identify two categories of genomic alterations: shared alterations, associated with tumorigenesis, and dedifferentiated-specific alterations, associated with malignant transformation. This large-scale genomic analysis reveals the mechanisms underlying the development and progression of DDLPS and provides insights that could contribute to the refinement of DDLPS management.

DOI： 10.1038/s41467-019-13286-z

Clinical Frailty Scale Score before ICU Admission Is Associated with Mobility Disability in Septic Patients Receiving Early Rehabilitation Reviewed Open Access

Nakajima H., Nishikimi M., Shimizu M., Hayashi K., Inoue T., Nishida K., Takahashi K., Matsui S., Nishida Y., Matsuda N.

Critical Care Explorations Vol. 1 ( 12 ) page： e0066 2019.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Critical Care Explorations

Objectives: To clarify the relationship between mobility disability at the time of discharge from the ICU and clinical factors evaluated at ICU admission in septic patients. Design: A single-center, retrospective, observational study. Setting: Ten-bed, the emergency and medical ICU. Patients: We analyzed the data of septic patients who were admitted to our ICU between September 2012 and September 2016 and received early rehabilitation. Interventions: None. Measurements and Main Results: The patients were categorized into two groups based on their scores on the ICU mobility scale at the time of discharge from the ICU: The mobility disability group (ICU mobility scale score < 9) and the no mobility disability group (ICU mobility scale score ≥ 9). Of the 110 eligible patients, 63 met the inclusion criteria; of these, 46 patients (73%) were classified into the mobility disability group, and 17 patients (27%) were classified into the no mobility disability group. The age (median, 72 vs 64 yr; p = 0.024), prevalence of patients with clinical frailty scale scores of greater than or equal to 5 (54% vs 12%; p = 0.003), Sequential Organ Failure Assessment score (median, 9.0 vs 6.0; p = 0.006) and rate of vasopressin use (26% vs 0%; p = 0.026) were significantly higher in the mobility disability group as compared with the no mobility disability group. Among the candidate variables for which values recorded before/at the time of ICU admission were available, the clinical frailty scale score was identified as the only independent, statistically significant predictor of mobility disability at ICU discharge (odds ratio, 7.77; 95% CI, 1.37-44.21; p = 0.021). The positive predictive value and negative predictive value of clinical frailty scale scores greater than or equal to 5 for mobility disability at ICU discharge were 92.6% and 41.7%, respectively. Conclusions: The clinical frailty scale score was associated with increased mobility disability at ICU discharge in septic patients receiving early rehabilitation.

DOI： 10.1097/CCE.0000000000000066

Open Access

Scopus

PubMed

Treatment Outcome of Patients With Osteosarcoma in Children and Adolescent. A Single Center Retrospective Analysis Reviewed

Akita, N; Sekimizu, M; Hattori, H; Arai, E; Nishida, Y; Horibe, K; Maeda, N

PEDIATRIC BLOOD & CANCER Vol. 66 page： S59 - S59 2019.12

Clinical Features of Thoracic Myelopathy: A Single-Center Study. Reviewed

Ando K, Imagama S, Kobayashi K, Ito K, Tsushima M, Morozumi M, Tanaka S, Machino M, Ota K, Nakashima H, Nishida Y, Ishiguro N.

J Am Acad Orthop Surg Glob Res Rev. Vol. 3 ( 11 ) page： - 2019.11

Outcome of Cancer Clinical Researches Using Heat-Generating Nanoparticles and Novel Concept of its Therapeutic Use Open Access

YAMAMOTO NORIYUKI, MORINO TOMIO, YASUI TAKAHIRO, NAIKI TAKU, KAWAI NORIYASU, ETANI TOSHIKI, KIKUMORI TOYONE, NISHIDA YOSHIHIRO

Thermal Medicine Vol. 35 ( 3 ) page： 23 - 32 2019.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Thermal Medicine

Cancer clinical researches using heat-generating nanoparticles have been conducted in four Japanese universities including authors' universities. The nanoparticles were injected intratumorally and its heat generation was induced by external magnetic field irradiation to kill cancer cells. Three kinds of composite magnetites nanoparticles were applied to clinical researches in combination with either types of magnetic field irradiators generating different frequencies. In this paper we reviewed results of these researches with our unpublished data and discussed its potential and further refinement.Critical issues of clinical feasibility were not found in key process of treatment such as nanoparticles injection, magnetites imaging and magnetic field irradiation. A combinational use of magnetite cationic liposomes (MCL) and alternating magnetic field (AMF) irradiator was found to exhibit tumor regression activity without adverse events such as skin burn and histological damages of surrounding normal tissues. However, efficacies were found variable among tumors whose temperature rise was commonly achieved. In order to ensure efficacy, we discussed importance of MCL dosage divided by tumor volume (mg/cm3) and proposed total heat dose divided by tumor volume (J/cm3) as candidate index to control clinical treatments.

DOI： 10.3191/thermalmed.35.23

Open Access

CiNii Research

Cilostazol use is associated with FIM cognitive improvement during convalescent rehabilitation in patients with ischemic stroke: a retrospective study Reviewed Open Access

Senda, J; Ito, K; Kotake, T; Kanamori, M; Kishimoto, H; Kadono, I; Nakagawa-Senda, H; Wakai, K; Katsuno, M; Nishida, Y; Ishiguro, N; Sobue, G

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 3 ) page： 359 - 373 2019.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Nagoya Journal of Medical Science

Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that is often used to prevent stroke and peripheral artery disease, and its administration has shown significant improvements for cognitive impairment. We investigate the potential of cilostazol for reducing or restoring cognitive decline during convalescent rehabilitation in patients with non-cardioembolic ischemic stroke. The study sample included 371 consecutive patients with lacunar (n = 44) and atherothrombosis (n = 327) subtypes of non-cardioembolic ischemic stroke (224 men and 147 women; mean age, 72.9 ± 8.1 years) who were required for inpatient convalescent rehabilitation. Their medical records were retrospectively surveyed to identify those who had received cilostazol (n = 101). Patients were grouped based on cilostazol condition, and Functional Independence Measure (FIM) scores (total and motor or cognitive subtest scores) were assessed both at admission and discharge. The gain and efficiency in FIM cognitive scores from admission to discharge were significantly higher in patients who received cilostazol than those who did not (p = 0.047 and p = 0.035, respectively); we found no significant differences in other clinical factors or scores. Multiple linear regression analysis confirmed that cilostazol was a significant factor in FIM cognitive scores at discharge (β = 0.041, B = 0.682, p = 0.045); the two tested dosages were not significantly different (100 mg/day, n = 43; 200 mg/day, n = 58). Cilostazol can potentially improve cognitive function during convalescent rehabilitation of patients with non-cardioembolic ischemic stroke, although another research must be needed to confirm this potential.

DOI： 10.18999/nagjms.81.3.359

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Papers - NISHIDA, Yoshihiro