Faculty Profiles - NISHIDA, Yoshihiro

Papers - NISHIDA, Yoshihiro

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Whole genome and transcriptome analysis of bone and soft tissue sarcomas Reviewed

Hirai, T; Katayama, K; Shiraishi, Y; Kawai, A; Yoshida, A; Kobayashi, H; Ohtsu, T; Kunisada, T; Nishida, Y; Yoshida, S; Kondo, T; Shibata, T; Imoto, S; Matsuda, K; Hirata, M

CANCER SCIENCE Vol. 115 page： 384 - 384 2024.3

TGF-β signaling promotes desmoid tumor formation via CSRP2 upregulation Reviewed Open Access

Li, Y; Fujishita, T; Mishiro-Sato, E; Kojima, Y; Niu, YQ; Taketo, MM; Urano, Y; Sakai, T; Enomoto, A; Nishida, Y; Aoki, M

CANCER SCIENCE Vol. 115 ( 2 ) page： 401 - 411 2024.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Cancer Science

Desmoid tumors (DTs), also called desmoid-type fibromatoses, are locally aggressive tumors of mesenchymal origin. In the present study, we developed a novel mouse model of DTs by inducing a local mutation in the Ctnnb1 gene, encoding β-catenin in PDGFRA-positive stromal cells, by subcutaneous injection of 4-hydroxy-tamoxifen. Tumors in this model resembled histologically clinical samples from DT patients and showed strong phosphorylation of nuclear SMAD2. Knockout of SMAD4 in the model significantly suppressed tumor growth. Proteomic analysis revealed that SMAD4 knockout reduced the level of Cysteine-and-Glycine-Rich Protein 2 (CSRP2) in DTs, and treatment of DT-derived cells with a TGF-β receptor inhibitor reduced CSRP2 RNA levels. Knockdown of CSRP2 in DT cells significantly suppressed their proliferation. These results indicate that the TGF-β/CSRP2 axis is a potential therapeutic target for DTs downstream of TGF-β signaling.

DOI： 10.1111/cas.16037

The relationship between preoperative foot alignment and postoperative outcomes in patients who underwent initial total knee arthroplasty Reviewed Open Access

Hishida, A; Hiraiwa, H; Kadono, I; Yamaguchi, H; Okada, T; Terai, C; Kayamoto, A; Nishida, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 86 ( 1 ) page： 91 - 103 2024.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Nagoya Journal of Medical Science

We compared the relationship between foot alignments and quality of life in patients who underwent initial total knee arthroplasty (TKA). Among the patients with knee osteoarthritis (KOA) who underwent TKA from May 2015 to May 2017 at our hospital, we focused on those in whom weight-bearing foot radiographs had been evaluated preoperatively. The hallux valgus angle and Meary angle were measured by preoperative radiography, and those with hallux valgus angles of 20 degrees or more were classified into the hallux valgus (HV) group, and those with Meary angles of 4 degrees or more into the high arch (HA) group. Also knee and ankle range of motion, knee pain Visual Analog Scale, and the 36-item short-form health survey (SF-36) were measured preoperatively and at discharge, and the amount of these changes was compared in the presence/absence of HV and HA. Regarding HV, there were no significant differences in any of these items between the HV and non-HV groups. However, the SF-physical function was significantly lower in the HA group than in the normal group. In addition, ankle dorsiflexion was lower in the HA group than that in the normal group, although this difference was not statistically significant. There was little improvement of the ankle dorsiflexion, and it was associated with deterioration of the physical function items of SF-36. In total knee arthroplasty patients with HA, physical therapy of the ankles and feet, as well as of the knees, was considered to enhance the improvement of physical function.

DOI： 10.18999/nagjms.86.1.91

Clinical Outcomes of a Novel Unidirectional Porous β-Tricalcium Phosphate Filling in Distal Radius Fracture with Volar Locking Plate Fixation: Secondary Publication of the Japanese Version Reviewed Open Access

Sudo, Y; Nishida, Y; Nakashima, H; Arai, T; Takatsu, T

MEDICINA-LITHUANIA Vol. 60 ( 1 ) 2024.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicina Lithuania

Postoperative loss of correction is a concern in cases of distal radius fracture with bone loss after surgery. The purpose of this study was to evaluate the usefulness of a β-tricalcium phosphate (β-TCP) with unidirectional pore structure (Affinos®: Kuraray Co., Ltd, Tokyo, Japan) with internal fixation in patients with bone defects during the correction of distal radius fractures. Thirty-nine patients (40 radii) treated between 2016 and August 2020 were included in the study. There were 8 males and 31 females; the mean age was 70.9 (32–88). The mean postoperative observation period was 14.6 (3.4–24) months. The bone defect that occurred in the surgery was filled with Affinos® and fixed with a locking plate. Radial inclination (RI), volar tilt (VT), and ulnar variance (UV) were evaluated after the operation and at the final observation. The start of absorption and the completion of replacement to the host bone of Affinos® were also evaluated. There were no complications associated with grafts of Affinos®. The mean time of translucent findings around artificial bone was 1.85 (0.5–6) months, and that of complete resorption was 10.6 (1.5–16.5) months after surgery. The mean RI was 21.82° after surgery and 21.16° at final observation. The mean VT was 8.54° after surgery and 8.50° at final observation. The mean UV was −0.3 mm after surgery and 0.5 mm at final observation. Affinos® was resorbed relatively early, and host bone formation was observed. Filling of unidirectional pore structure β-TCP with internal fixation showed favorable outcomes in the surgery of distal radius fractures with bone defects.

DOI： 10.3390/medicina60010001

Potential drug interactions between pazopanib and proton pump inhibitors/potassium-competitive acid blockers in patients with soft tissue sarcoma Reviewed Open Access

Liang, Y; Maeda, O; Shimokata, T; Yokota, K; Koike, H; Sakai, T; Ikuta, K; Urakawa, H; Nishida, Y; Akiyama, M; Ando, Y

INTERNATIONAL CANCER CONFERENCE JOURNAL Vol. 13 ( 1 ) page： 63 - 67 2024.1

TWO CASES OF OSTEOSARCOMA WITH FAVORABLE LONG-TERM DISEASE CONTROL WITH GEMCITABINE AND DOCETAXEL COMBINATION THERAPY Reviewed

Ichikawa, D; Kikui, H; Sekimizu, M; Hattori, H; Koike, H; Ikuta, K; Nishida, Y; Horibe, K; Maeda, N

PEDIATRIC BLOOD & CANCER Vol. 71 page： S35 - S36 2024.1

これからの生物学的再建　骨・軟部腫瘍手術における遊離血管柄付き骨移植による再建 Reviewed

生田国大, 酒井智久, 小池宏, 藤戸健雄, 西田佳弘

日本整形外科学会雑誌 Vol. 98巻 page： 805 - 809 2024

膝関節周囲軟部肉腫術後の膝関節機能の検討 Reviewed

小池宏, 生田国大, 西田佳弘

日本整形外科学会雑誌 Vol. 98 2024

後頸部軟部腫瘍の1例 Reviewed

小池宏, 酒井智久, 西田佳弘, 生田国大

東海骨軟部腫瘍 Vol. 30巻 page： 17 - 18 2024

左大腿軟部腫瘍の1例 Reviewed

酒井智久, 生田国大, 小池宏, 伊藤鑑, 西田佳弘

東海骨軟部腫瘍 Vol. 30 page： 43 - 44 2024

右大腿骨遠位骨腫瘍の1例 Reviewed

小池宏, 生田国大, 酒井智久, 伊藤鑑, 西田佳弘

東海骨軟部腫瘍 Vol. 30 page： 27 - 28 2024

右下腿軟部腫瘍の1例 Reviewed

小池宏, 生田国大, 酒井智久, 西田佳弘

東海骨軟部腫瘍 Vol. 30巻 page： 11 - 12 2024

A Case of Intractable Complex Regional Pain Syndrome Successfully Treated with a Combination of Regional Anesthesia and Physical Therapy

Ando Takahiro, Nishiwaki Kimitoshi, Yamaguchi Hidetoshi, Nishida Yoshihiro, Hishida Aika

The Japanese Journal of Rehabilitation Medicine Vol. 60 ( 12 ) page： 1105 - 1110 2023.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association of Rehabilitation Medicine

We report a case of intractable complex regional pain syndrome (CRPS). The pain improved with regional anesthesia and physical therapy.A 24-year-old man with hemophilia A, developed throbbing pain from his left foot to the ankle, with no identifiable cause. No organic abnormalities were observed. He diagnosed with CRPS at the pain clinic and admitted to the hospital 10 months after symptom onset for physical therapy with regional anesthesia under clotting factor replacement therapy. Spinal anesthesia was administered on the first and second day of hospitalization, and plantar load stimulation and ankle stretching were performed in the operating room. Subsequently, sciatic nerve blocks and continuous epidural blocks were given, and plantar contact training, ankle joint ROM training, and parallel bar walking training were conducted with cognitive behavioral therapy. Sciatic nerve blocks were continued after discharge. Ninety-five days after onset, the patient was re-admitted for physical therapy, and ROM exercises, partial weight bearing, and gait training together with sciatic nerve blocks and cognitive-behavioral therapy. On discharge following re-admission, the pain improved. The patient walked using one crutch. One year later, the pain further improved, and the patient walked independently.The combination of regional anesthesia, physical therapy, and cognitive behavioral therapy created a virtuous cycle of pain relief, improved physical functions, and prevented withdrawal from catastrophizing, ultimately leading to overall improvement.

DOI： 10.2490/jjrmc.23008

CiNii Research

In-Hospital Fall Risk Prediction by Objective Measurement of Lower Extremity Function in a High-Risk Population Reviewed Open Access

Tanaka, S; Imaizumi, T; Morohashi, A; Sato, K; Shibata, A; Fukuta, A; Nakagawa, R; Nagaya, M; Nishida, Y; Hara, K; Katsuno, M; Suzuki, Y; Nagao, Y

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 24 ( 12 ) page： 1861 - 1867.e2 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of the American Medical Directors Association

Objectives: Limited data exist regarding association between physical performance and in-hospital falls. This study was performed to investigate the association between physical performance and in-hospital falls in a high-risk population. Design: Retrospective cohort study. Setting and Participants: The study population consisted of 1200 consecutive patients with a median age of 74 years (50.8% men) admitted to a ward with high incidence rates of falls, primarily in the departments of geriatrics and neurology, in a university hospital between January 2019 and December 2021. Methods: Short Physical Performance Battery (SPPB) was measured after treatment in the acute phase. As the primary end point of the study, the incidence of in-hospital falls was examined prospectively based on data from mandatory standardized incident report forms and electronic patient records. Results: SPPB assessment was performed at a median of 3 days after admission, and the study population had a median SPPB score of 3 points. Falls occurred in 101 patients (8.4%) over a median hospital stay of 15 days. SPPB score showed a significant inverse association with the incidence of in-hospital falls after adjusting for possible confounders (adjusted odds ratio for each 1-point decrease in SPPB: 1.19, 95% CI 1.10-1.28; P < .001), and an SPPB score ≤6 was significantly associated with increased risk of in-hospital falls. Inclusion of SPPB with previously identified risk factors significantly increased the area under the curve for in-hospital falls (0.683 vs. 0.740, P = .003). Conclusion and Implications: This study demonstrated an inverse association of SPPB score with risk of in-hospital falls in a high-risk population and showed that SPPB assessment is useful for accurate risk stratification in a hospital setting.

DOI： 10.1016/j.jamda.2023.07.020

Clinical Outcome in Patients With High-grade Soft-tissue Sarcoma Receiving Prosthetic Replacement After Tumor Resection of the Lower Extremities: Tokai Musculoskeletal Oncology Consortium Study Reviewed Open Access

Nakamura, T; Sakai, T; Tsukushi, S; Kimura, H; Wasa, J; Hosono, K; Izubuchi, Y; Kozawa, E; Nagano, A; Asanuma, K; Sudo, A; Nishida, Y

IN VIVO Vol. 37 ( 6 ) page： 2642 - 2647 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：In Vivo

Aim: This multicenter retrospective study aimed to clarify the surgical and oncological outcomes of patients with high-grade soft tissue sarcoma (STS) who underwent prosthetic replacement reconstruction after lower extremity tumor resection. Patients and Methods: We retrospectively collected the data of 27 patients with high-grade STS. The mean follow-up duration after prosthetic replacement was 44.7 months. Results: The mean age at surgery was 63 years. The mean tumor size was 16 cm. For reconstruction, proximal femur replacement was performed in 15 patients, distal femur replacement in six, and total femur replacement in six. The major complications were infections in nine patients and aseptic loosening in four. Nine patients developed local recurrence. The cause of revision surgery was infection in five patients, aseptic loosening in three, and metal allergy in one. The 5-year prosthetic survival rate was 51.1%. At the final follow-up, amputation was performed in five patients. The 5-year limb salvage rate was 76.8%. The mean functional score of the 25 patients who could be assessed was 16.0 (53%). Of the 27 patients, five were excluded from the survival analysis because they underwent prosthetic replacement for local recurrence. The 5-year overall survival rate in the remaining 22 patients was 45.3%. Conclusion: We identified a high rate of surgical complications and poor survival in patients with high-grade STS who underwent tumor resection and reconstruction using prosthetic replacement of the lower extremities, although limb salvage was achieved in 81.5% of the patients. Careful follow-up is needed for surgical complications and oncological events after surgery.

DOI： 10.21873/invivo.13372

Phase I trial of NY-ESO-1 TCR-T cell therapy combined with nanoparticulate vaccine but without lymphodepletion for STS Reviewed Open Access

Ishihara, M; Nishida, Y; Kitano, S; Kawai, A; Harada, N; Miyahara, Y; Hattori, H; Takada, K; Emori, M; Kakunaga, S; Endo, M; Matsumoto, Y; Sasada, T; Sato, E; Yamada, T; Matsumine, A; Nagata, Y; Kageyama, S; Shiku, H

ANNALS OF ONCOLOGY Vol. 34 page： S1391 - S1391 2023.11

Clinical investigation for the mechanisms of anaphylactic symptoms in osteoarthritis patients after diclofenac etalhyaluronate administration Reviewed Open Access

Nishida, Y; Yagami, A; Takada, S; Muramatsu, D; Nobuoka, Y; Okayama, Y

MODERN RHEUMATOLOGY Vol. 34 ( 4 ) page： 820 - 830 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Modern Rheumatology

Objective: This study was conducted to investigate the mechanisms of anaphylaxis in patients with osteoarthritis of the knee and hip after diclofenac etalhyaluronate [product name: JOYCLU® (JCL)] intra-articular injection and to determine the utility of tests to investigate the mechanism involved. Methods: In this observational study in Japan, patients aged ≥20 years with knee or hip osteoarthritis who received JCL intra-articular injection experienced anaphylactic symptoms considered related to JCL (‘experienced patients’) or did not experience allergic symptoms considered related to JCL (‘non-experienced patients’). Basophil activation tests (BATs), specific immunoglobulin E (IgE) antibody testing by enzyme-linked immunosorbent assays (ELISAs) or immunochromatographic kit, and genome-wide association studies (GWASs) were conducted using patient blood and saliva. Results: Thirteen experienced patients and 14 non-experienced patients were tested. Seven experienced patients tested positive by BAT using diclofenac etalhyaluronate-containing test substances. Diclofenac-specific IgE antibodies were detected in four of seven BAT-positive patients but not in the non-experienced patients. Specific IgE antibody testing by immunochromatographic kit and genome-wide association study showed no clear results. Conclusions: These findings suggest that anaphylaxis occurs after JCL administration via an IgE-mediated mechanism and that diclofenac etalhyaluronate may be involved in this mechanism. BAT and diclofenac-specific IgE enzyme-linked immunosorbent assay may be useful tests for investigating the mechanisms of anaphylactic reactions after JCL administration.

DOI： 10.1093/mr/road100

The current management of clear cell sarcoma Reviewed

Ikuta, K; Nishida, Y; Imagama, S; Tanaka, K; Ozaki, T

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 53 ( 10 ) page： 899 - 904 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Oncology

Clear cell sarcoma (CCS) is a rare melanocytic soft tissue sarcoma with a high propensity for lymphatic metastasis and poor prognosis. It is characterized by the translocation of t (12;22), resulting in the rearrangement of the EWSR1 gene and overexpression of MET. Despite improvements in the diagnosis and treatment of soft tissue sarcomas, the management of CCSs remains challenging owing to their rarity, unique biological behaviour and limited understanding of their molecular pathogenesis. The standard treatment for localized CCSs is surgical excision with negative margins. However, there is an ongoing debate regarding the role of adjuvant chemotherapy, radiotherapy and lymphadenectomy in the management of this disease. CCSs are usually resistant to conventional chemotherapy. Targeted therapies, such as sunitinib and MET inhibitors, may provide promising results. Immunotherapy, particularly immune checkpoint inhibitors, is currently under investigation as a potential treatment option for CCSs. Further research is needed to better understand the biology of CCSs and develop effective therapeutic strategies. The purpose of this review is to provide a comprehensive overview of current knowledge and advances in the diagnosis and treatment of CCSs.

DOI： 10.1093/jjco/hyad083

Web of Science

Scopus

PubMed

Efficacy of rehabilitation initiated in the early phase after simultaneous deceased donor liver and kidney transplantation: A case report Reviewed Open Access

Tanaka, S; Mizuno, Y; Nojiri, S; Futamura, D; Nagaya, M; Nishida, Y; Sano, Y; Ishida, S; Kato, M; Kurata, N; Jobara, K; Fujimoto, Y; Ogura, Y

MEDICINE Vol. 102 ( 38 ) page： e35324 2023.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicine United States

Rationale: The purpose of this case report is to describe a case of successful early rehabilitation intervention for simultaneous liver and kidney transplantation (SLKT). Patient concerns: A 51-year-old Japanese man was diagnosed with Caroli disease 27 years ago. Hemodialysis was introduced due to end-stage renal disease 17 years ago. Diagnoses: After successful SLKT, the patient was extubated on postoperative day (POD) 1, liberated from dialysis on POD 4, and discharged from the intensive care unit on POD 9. Interventions: Supervised rehabilitation was started on POD 2, and the patient was able to walk 100 m on POD 9. Electrical muscle stimulation therapy was started to improve muscle weakness in both legs on POD 16, and aerobic exercise using a cycle-ergometer was started on POD 24. Outcomes: The 6-minute walking distance improved from 324 m on POD 14 to 501 m on POD 28. The patient could walk 4000 to 5000 steps per day at hospital discharge, and was discharged home on POD 32. There were no adverse events, including worsening hepatic or renal function, during the rehabilitation period. One month after discharge, the patient was able to perform 30 to 40 minutes of aerobic exercise every day, and returned to work 5 months after discharge. Lessons: This case shows that early rehabilitation intervention immediately after SLKT safely and rapidly improved physical performance without adverse events. The results in the present case suggest that regular physical assessment and appropriate interventions with a variety of exercise modalities can contribute to improved physical performance in SLKT patients.

DOI： 10.1097/MD.0000000000035324

Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study Reviewed Open Access

Yamamoto, H; Tanaka, S; Kasugai, D; Shimizu, M; Tsuchikawa, Y; Hori, Y; Fugane, Y; Inoue, T; Nagaya, M; Omote, N; Higashi, M; Yamamoto, T; Jingushi, N; Numaguchi, A; Goto, Y; Nishida, Y

SCIENTIFIC REPORTS Vol. 13 ( 1 ) page： 14529 2023.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

This prospective observational cohort study was performed to investigate the physical function and mental health trajectories of novel coronavirus disease 2019 (COVID-19) patients requiring invasive mechanical ventilation (IMV) after discharge from the intensive care unit (ICU). The study population consisted of 64 patients (median age, 60 years; 85.9% male; median IMV duration, 9 days). At ICU discharge, 28.1% of the patients had Medical Research Council (MRC) sum score < 48 points, and prolonged IMV was significantly associated with lower MRC sum score and handgrip strength. Symptoms were similar between groups at ICU discharge, and the symptoms most commonly reported as moderate-to-severe were impaired well-being (52%), anxiety (43%), tiredness (41%), and depression (35%). Although muscle strength and mobility status were significantly improved after ICU discharge, Edmonton Symptom Assessment System score did not improve significantly in the prolonged IMV group. EuroQol five-dimension five-level summary index was significantly lower in the prolonged than short IMV group at 6 months after ICU discharge. We found substantial negative physical function and mental health consequences in the majority of surviving COVID-19 patients requiring IMV, with prolonged period of IMV showing greater negative effects not only immediately but also at 6 months after discharge from the ICU.

DOI： 10.1038/s41598-023-41684-3

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Papers - NISHIDA, Yoshihiro