Faculty Profiles - NISHIDA, Yoshihiro

Predictive variables for intraoperative blood loss and surgical time in resection of malignant soft tissue tumors without reconstruction Reviewed

Nakamura, T; Kobayashi, E; Takenaka, S; Endo, M; Hayashi, K; Nakata, E; Ohshika, S; Kawashima, H; Hamada, T; Horiuchi, K; Nishida, Y; Hasegawa, M; Morii, T

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 55 ( 6 ) page： 610 - 614 2025.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Oncology

Background Procedural techniques such as dissection and separation of blood vessels or nerves from the tumor for preserving limbs and functions involves high surgical difficulty. We hypothesized the relation of vessel and/or nerve preservation to surgical time and blood loss, accurately reflecting surgical difficulty. In this study, we elucidated the variables affecting surgical time and intraoperative bleeding in patients with malignant soft tissue tumors who did not undergo any reconstruction after tumor resection. Methods We included 153 patients with malignant oft tissue tumors in the trunk (n = 72), thigh (n = 68), and upper arm (n = 13) at nine institutions. We analyzed the possible predictive variables affecting surgical time and intraoperative bleeding. Results Overall, the study included 153 patients (85 men and 68 women) with a mean age of 65 years. The tumors were primary soft tissue sarcoma (STS) (n = 114), local recurrent STS (n = 25), and soft tissue metastasis (n = 14). The median number of participating surgeons was three. The mean and median surgical time were 144.6 and 123 min, respectively. The mean and median intraoperative bleeding were 157.1 and 55 mL, respectively. Tumor size, depth, dissection and separation of blood vessels from the tumor, dissection and separation of nerve from the tumor, and the number of participating surgeons were significantly related to the surgical time and intraoperative bleeding. Conclusions The procedure of dissection and separation of blood vessels and nerves from the tumor were related to surgical time and intraoperative bleeding in patients with malignant soft tissue tumors, especially large and deep tumors.

DOI： 10.1093/jjco/hyaf030

希少疾患患者へのリハビリテーション診療は必須である

Clinical factors associated with valgus knee deformities in patients with multiple osteochondromas Reviewed Open Access

Ito, K; Nishida, Y; Ikuta, K; Urakawa, H; Sakai, T; Koike, H; Nishida, K; Imagama, S

MEDICINE Vol. 104 ( 19 ) page： e42359 2025.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Medicine United States

Multiple osteochondromas (MO) occur in approximately 1 in 50,000 people/yr. One in 3 patients with MO will develop valgus knee deformity (VKD), but the predictive factors for VKD are unclear. The purpose of this study was to examine the factors associated with VKD in patients with MO. From January 2003 to December 2018, 64 patients with MO visited the Nagoya University Hospital for the 1st time. Thirty-three patients with 66 limbs were sequentially included in the study after excluding 12 patients with a history of lower extremity surgery, 15 patients whose knee X-rays were unavailable, and 4 patients whose age at the last examination was <7 years. Limbs with femorotibial angle (FTA)≥175° were defined as the normal group (Group N) and limbs with FTA<175° as the valgus group (Group V), and clinical factors collected retrospectively from the medical records were compared between the 2 groups. The initial and final X-rays were compared in a subgroup analysis of 8 patients whose initial examination was <10 years old and who were followed for more than 5 years. Twenty-four males and 9 females with a median age of 17 years at the last X-rays were included in the study. The mean follow-up period was 43±53 months, and the median FTA was 174.5°. Group N consisted of 32 limbs and Group V consisted of 34 limbs. Multivariate analysis was performed using the 5 factors with P-values <.15 in the univariate analysis of comparison between the 2 groups, and only medial proximal tibial angle showed significant differences (P<.001). In the subgroup analysis, multivariate analysis showed that the femoral neck-shaft angle showed significant differences between the 2 groups at the initial evaluation (P<.001). Our study suggests that medial proximal tibial angle is associated with VKD in patients with MO. Small neck-shaft angle was significantly associated with VKD, even before it became obvious. In order to study how VKD is formed, imaging of the hip and ankle joints and X-rays of the entire lower extremity should be performed in more cases.

DOI： 10.1097/MD.0000000000042359

Prognostic impact of preoperative cachexia in patients undergoing major hepatopancreatobiliary surgery for malignancy Reviewed Open Access

Fugane, Y; Tanaka, S; Mizuno, Y; Nakajima, H; Yamamoto, H; Inoue, T; Nagaya, M; Nishida, Y; Onoe, S; Yamaguchi, J; Mizuno, T; Yokoyama, Y; Ebata, T

CLINICAL NUTRITION Vol. 47 page： 112 - 118 2025.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical Nutrition

Background & aims: Data regarding the association between cachexia and clinical outcomes in hepatopancreatobiliary (HPB) malignancies are limited. This retrospective study sought to investigate the prognostic significance of preoperative cachexia in patients undergoing major HPB surgery for malignancies. Methods: Data from patients, who underwent major open surgery for HPB malignancies between March 2014 and December 2018, were retrospectively reviewed. Cachexia was evaluated a few days before surgery, and defined according to modified Asian Working Group for Cachexia criteria: low body mass index (<21 kg/m2) and decreased handgrip strength (<28 kg [males] and <18 kg [females]) or elevated C-reactive protein level (>0.5 mg/dL). The primary endpoint was postoperative overall survival (OS); secondary endpoints included disease-free survival (DFS) and postoperative complications. Results: Of 332 patients (228 male; mean age, 68.8 ± 10.3 years), 93 (28 %) had preoperative cachexia. There were 154 (46 %) deaths and 181 (55 %) combined events (death or recurrence) during a five-year follow-up (mean, 3.3 ± 1.7 years), with no significant differences in major postoperative complications between the 2 groups (P = 0.329). After adjusting for covariates, cachexia (n = 93) exhibited significant associations with shorter OS (adjusted hazard ratio [HR] 1.65 [95 % confidence interval (CI) 1.18–2.30]; P = 0.004) and DFS (adjusted HR 1.39 [95 % CI 1.01–1.91; P = 0.043) compared with non-cachexia (n = 239). Cachexia significantly shortened OS only in a subset with pathological stage ≤ II disease (adjusted HR 2.45 [95 % CI 1.27–4.74]; P = 0.008) but not otherwise (P for interaction, 0.040). Conclusions: Preoperative cachexia did not affect short-term surgical complications but significantly deteriorated postoperative prognosis in patients who underwent surgery for HPB malignancies.

DOI： 10.1016/j.clnu.2025.02.014

Tocilizumab treatment for inflammatory dedifferentiated liposarcoma: pre- and posttreatment imaging and pathological changes Reviewed Open Access

Nishida, Y; Shimada, S

ESMO OPEN Vol. 10 ( 4 ) page： 104530 2025.4

Selumetinib for symptomatic, inoperable plexiform neurofibromas in pediatric patients with neurofibromatosis type 1: the first single-center real-world case series in Japan Reviewed Open Access

Nishida, Y; Nonobe, N; Kidokoro, H; Kato, T; Takeichi, T; Ikuta, K; Urakawa, H; Sakai, T; Koike, H; Fujito, T; Imagama, S

JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 55 ( 4 ) page： 372 - 376 2025.4

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Oncology

Objective: In Japan, selumetinib is used in pediatric patients with neurofibromatosis type 1 (NF1) and symptomatic inoperable plexiform neurofibroma (PN). However, there have been no real-world reports on Japanese patients. In this study, we reported a single-center, short-term experience with selumetinib after its approval in Japan. Methods: We prospectively collected data from 11 pediatric NF1 patients with symptomatic, inoperable PN who were initiated on selumetinib between November 2022 and May 2023; the selumetinib was administered by the same physician. Various patient factors, tumors, dose and efficacy of selumetinib, and adverse events (AE) were investigated. Results: Of 11 patients included, 7 were male, with a mean age of 14 years. The sites of symptomatic main PN included the head and neck, pelvis to lower extremities, and paraspinal lesions in five, three, and three patients, respectively. The median maximum diameter of the main PN was 91 mm, and the median follow-up duration was 19 months. All patients with pain or motor dysfunction experienced symptom improvement after treatment, and the tumors tended to shrink in 7 of the 11 patients (64%). Among the six patients with disfigurements, only one experienced improvement. Of 59 AEs observed, 58 (98%) were grades 1 and 2, and 5 patients (46%) underwent temporary selumetinib withdrawal due to AEs. One patient discontinued the drug (9%) because of rash dermatitis. Conclusions: Despite the relatively short-term results, no serious AEs were observed, and many patients benefited from selumetinib treatment. In some patients, administration was discontinued or interrupted because of the balance between benefits and AEs, and further data are needed to better understand the general safety and efficacy of selumetinib.

DOI： 10.1093/jjco/hyae184

Activated cardiac fibroblasts are a primary source of high-molecular-weight hyaluronan production Reviewed Open Access

Little, DT; Howard, CM; Pendergraft, E; Brittian, KR; Audam, TN; Lukudu, EW; Smith, J; Nguyen, D; Nishida, Y; Yamaguchi, Y; Brainard, RE; Singhal, RA; Jones, SP

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY Vol. 328 ( 3 ) page： C939 - C953 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Physiology Cell Physiology

During acute myocardial infarction, the composition of the extracellular matrix changes remarkably. One of the most notable changes in the extracellular matrix is in the accumulation of collagen; however, hyaluronan rivals collagen in its abundance. Yet, the extent to which specific cells and enzymes may contribute to such accumulation has been largely unexplored. Here, we hypothesized that activated cardiac fibroblasts produce hyaluronan via hyaluronan synthase 2 (HAS2). We show that hyaluronan accumulates following myocardial infarction and persists through at least 4 wk. Our analyses of failing heart RNA sequencing data suggest that fibroblasts are the cells most changed in the expression of HAS2. Given these insights, we used HAS2 gain- and loss-of-function approaches to examine the extent to which activated cardiac fibroblasts produce hyaluronan. Transforming growth factor b (TGFb)-induced activation of fibroblasts caused a significant increase in Has2 mRNA and concomitant accumulation of hyaluronan >1 MDa in size. Deletion of Has2 abrogated TGFb-induced production of hyaluronan. In addition, overexpression of Has2 was sufficient to cause an increase in hyaluronan accumulation in the absence of TGFb-induced activation. Our data indicated negligible impacts of Has2 on proliferation, migration, and collagen production. Exposing fibroblasts to exogenous hyaluronan also had minimal impact on fibroblasts. We also assessed whether fibroblast-borne Hyal2 plays a role in the degradation of hyaluronan, and our data indicated little impact of Hyal2 on hyaluronan accumulation (or even any impacts on the transcriptional profile of fibroblasts). Activated fibroblasts produce high-molecular-weight hyaluronan via Has2, which occurs independent of other fibroblast functions.

DOI： 10.1152/ajpcell.00786.2024

Implant failure of the Compress prosthesis: a case report Reviewed Open Access

Koike, H; Ikuta, K; Urakawa, H; Sakai, T; Fujito, T; Nishida, Y; Imagama, S

JOURNAL OF MEDICAL CASE REPORTS Vol. 19 ( 1 ) page： 6 2025.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Medical Case Reports

Background: The Compress is designed to achieve bone formation and stability by applying pressure at the bone–implant interface, minimizing the likelihood of aseptic loosening, which is a complication of stem implants. Herein, we report two cases of implant failure using the Compress. Case presentation: Case 1 describes a 36 year-old Japanese man who underwent extraarticular tumor resection, Compress arthroplasty, and reconstruction with a gastrocnemius flap after preoperative chemotherapy for a secondary malignant giant cell tumor in the right distal femur. Postoperatively, partial weight-bearing was started at 6 weeks, and full weight-bearing was allowed at 10 weeks. One year after the surgery, a fall caused implant failure. No bone formation at the implant–bone interface was observed on radiographs immediately prior to the failure. Bone formation was achieved at the interface 1 year after revision arthroplasty, and the patient was able to walk unassisted with a brace. Case 2 describes a 14 year-old Japanese boy who underwent wide surgical resection of osteosarcoma in the left tibia, Compress arthroplasty, and reconstruction with a gastrocnemius flap after preoperative chemotherapy. The postoperative weight-bearing schedule was the same as that of case 1. One year after the surgery, the patient experienced implant failure. A revision arthroplasty was performed. One year after revision surgery, the patient was able to walk unassisted. Conclusion: Although the risk factors for Compress failure remain unknown, it is important to consider patient characteristics that may inhibit bone formation, implant selection, postoperative loading timing, and radiographs of bone formation at the implant interface when using the Compress.

DOI： 10.1186/s13256-024-05012-1

Japanese orthopaedic association (JOA) clinical practice guideline on the management of primary malignant bone tumors- Secondary publication Reviewed Open Access

Tsuchiya, K; Akisue, T; Ehara, S; Kawai, A; Kawano, H; Hiraga, H; Hosono, A; Hutani, H; Morii, T; Morioka, H; Nishida, Y; Oda, Y; Ogose, A; Shimose, S; Yamaguchi, T; Yamamoto, T; Yoshida, M

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 30 ( 1 ) page： 1 - 17 2025.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Science

Background: In Japan, there are currently no general guidelines for the treatment of primary malignant bone tumors. Therefore, the Japanese Orthopaedic Association established a committee to develop guidelines for the appropriate diagnosis and treatment of primary malignant bone tumors for medical professionals in clinical practice. Methods: The guidelines were developed in accordance with “Minds Clinical Practice Guideline Development Handbook 2014″ and “Minds Clinical Practice Guideline Development Manual 2017". The Japanese Orthopaedic Association's Bone and Soft Tissue Tumor Committee established guideline development and systematic review committees, drawing members from orthopedic specialists leading the diagnosis and treatment of bone and soft tissue tumors. Pediatricians, radiologists, and diagnostic pathologists were added to both committees because of the importance of multidisciplinary treatment. Based on the diagnosis and treatment algorithm for primary malignant bone tumors, important decision-making points were selected, and clinical questions (CQ) were determined. The strength of recommendation was rated on two levels and the strength of evidence was rated on four levels. The recommendations published were selected based on agreement by 70% or more of the voters. Results: The guideline development committee examined the important clinical issues in the clinical algorithm and selected 22 CQs. The systematic review committee reviewed the evidence concerning each CQ and a clinical value judgment was added by experts. Eventually, 25 questions were published and the text of each recommendation was determined. Conclusion: Since primary malignant bone tumors are rare, there is a dearth of strong evidence based on randomized controlled trials, and recommendations cannot be applied to all the patients. In clinical practice, appropriate treatment of patients with primary malignant bone tumors should be based on the histopathological diagnosis and degree of progression of each case, using these guidelines as a reference.

DOI： 10.1016/j.jos.2023.11.007

西田佳弘

Vol. 61 ( 12 ) page： 1128 - 1128 2024.12

Clinical Features and Postoperative Mobilization following Total Aortic Arch Replacement Open Access

Tanaka Shinya, Hori Yuto, Yoshito Natsumi, Takagi Daichi, Nishida Yoshihiro, Mutsuga Masato, Kobayashi Kiyonori, Shirai Yuya, Tokuda Yoshiyuki, Tsuchikawa Yohei

International Heart Journal Vol. 65 ( 6 ) page： 1075 - 1078 2024.11

Language：English Publishing type：Research paper (scientific journal) Publisher：International Heart Journal Association

Open thoracic aortic surgery is believed to necessitate more intensive rehabilitation. This study aimed to compare the progress of postoperative rehabilitation between standard and delayed mobilization. A retrospective review was conducted on 199 patients who underwent isolated total aortic arch replacement via median sternotomy. Cases of in-hospital mortality and postoperative stroke were excluded. Based on the current guidelines for cardiovascular rehabilitation of the Japanese Circulation Society, patients were categorized into standard mobilization (could sit on the edge of bed within 2 days) and delayed mobilization (could not do so) groups. Rehabilitation progress was compared among both groups. Initial mobilization was delayed in 100 patients (delayed mobilization group), primarily because of respiratory failure (46.0%). Preoperative risk characteristics, including EuroSCORE II (median, 2.9 versus 3.5), were similar between the standard and delayed mobilization groups. The delayed mobilization group had longer operation (median, 6.1 versus 8.0 hours, P < 0.001) and cardiopulmonary bypass (median, 3.2 versus 4.1 hours, P < 0.001) times. Independent ambulation occurred earlier in the standard mobilization group (median, 6.0 versus 8.0 days, P < 0.001).In conclusion, early initiation of sitting on the edge of the bed within 2 days was associated with earlier independent ambulation during postoperative rehabilitation, which supports the current guidelines. Longer operation and cardiopulmonary bypass times were associated with delayed mobilization initiation, suggesting the need for more tailored approaches in such cases.

DOI： 10.1536/ihj.24-261

尾﨑敏文, 大高洋平, 酒井良忠, 西村行秀, 西田佳弘, 藤原俊之, 宮本健史

Vol. 61 ( 11 ) page： 1120 - 1122 2024.11

JARM NEWS【Topics】新理事のご挨拶 Reviewed

酒井良忠, 西田佳弘, 尾﨑敏文, 西村行秀, 藤原俊之, 宮本健史, 大高洋平

リハビリテーション医学 Vol. 61 ( 11 ) page： 1120 - 1122 2024.11

Efficacy and Safety of Auranofin for Progressive Desmoid-Type Fibromatosis: The Study Protocol of an Open-Label Phase II Trial. Reviewed Open Access

Nishida Y, Ito K, Sakai T, Kinoshita F, Kuwatsuka Y, Kinoshita S, Imagama S

Cureus Vol. 16 ( 10 ) page： e71033 2024.10

Financial burden of surgical treatment for retroperitoneal sarcoma Reviewed

Yokoyama, Y; Sunagawa, M; Kurimoto, K; Sakai, T; Nishida, Y; Ebata, T; Kodera, Y

SURGERY TODAY Vol. 54 ( 10 ) page： 1201 - 1207 2024.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Surgery Today

Purposes: The purpose of this study was to compare the financial burden of surgery for retroperitoneal sarcoma (RPS) and gastric cancer (GC). Methods: All patients who underwent surgery for GC or RPS between 2020 and 2021 at Nagoya University Hospital were included. The clinical characteristics, surgical fees per surgeon, and surgical fees per hour were compared between the two groups. Results: The GC and RPS groups included 35 and 63 patients, respectively. In the latter group, 37 patients (59%) underwent tumor resection combined with organ resection; the most common organ was the intestine (n = 23, 37%), followed by the kidney (n = 16, 25%). The mean operative time (248 vs. 417 min, p < 0.001) and intraoperative blood loss (423 vs. 1123 ml, p < 0.001) were significantly greater in the RPS group than in the GC group. The mean surgical fee per surgeon was USD 1667 in the GC group and USD 1022 in the RPS group (p < 0.001) and USD 1388 and USD 777 per hour, respectively (p < 0.001). Conclusions: The financial burden of surgical treatment for RPS is unexpectedly higher than that for GC.

DOI： 10.1007/s00595-024-02831-z

The impact of goal-directed prehabilitation therapy on functional capacity in patients undergoing hepatobiliary and pancreatic surgery: A randomized clinical trial Reviewed Open Access

Mizuno, Y; Yokoyama, Y; Nakajima, H; Inoue, T; Tanaka, S; Nagaya, M; Inokawa, Y; Ando, M; Nishida, Y; Ebata, T

SURGERY Vol. 176 ( 2 ) page： 252 - 258 2024.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Surgery United States

Background: Emerging evidence has supported the idea that goal-directed prehabilitation is a promising approach to boost functional capacity in preoperative patients. However, its usefulness has not been tested in the hepatobiliary and pancreatic fields. The objective of this trial was to investigate the efficacy of goal-directed prehabilitation for improving functional capacity in patients who were planned to undergo major hepatobiliary and pancreatic operations. Methods: This assessor-blinded, parallel-arm, randomized clinical trial recruited patients who were scheduled for major hepatobiliary and pancreatic surgeries for malignancy. Patients were randomly allocated into the step goal-directed prehabilitation group as the test group and into the conventional prehabilitation group as the control group. Patients in the goal-directed prehabilitation group participated in a walking prehabilitation program with an intergrading goal of the step count. Patients in the conventional prehabilitation group received standard physical and nutritional prehabilitation. The primary outcome was change in the 6-minute walking distance, which ranged from the time before starting prehabilitation (baseline) to the time after completing prehabilitation (immediately before surgery). Results: Among 180 randomized patients, 144 patients were included in the primary analysis (73 patients in the conventional prehabilitation group and 71 patients in the goal-directed prehabilitation group). The mean change in the 6-minute walking distance was 27 meters in the conventional prehabilitation group and 31 meters in the goal-directed prehabilitation group (P = .633). Conclusion: In patients undergoing major hepatobiliary and pancreatic surgeries for malignancies, a goal-directed prehabilitation program did not result in a significantly greater increase in functional capacity than did conventional prehabilitation. Registration number: UMIN000038791 (https://www.umin.ac.jp/).

DOI： 10.1016/j.surg.2024.04.024

Final results of a randomized phase II/III study comparing perioperative adriamycin plus ifosfamide and gemcitabine plus docetaxel for high-grade soft tissue sarcomas: Japan Clinical Oncology Group study JCOG1306. Reviewed

Preoperative Sarcopenia Severity and Clinical Outcomes after Total Hip Arthroplasty Reviewed Open Access

Tanaka, S; Kayamoto, A; Terai, C; Nojiri, S; Fugane, Y; Mori, T; Nagaya, M; Kako, M; Iida, H; Osawa, Y; Takegami, Y; Nishida, Y

NUTRIENTS Vol. 16 ( 13 ) 2024.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Nutrients

The outcome of total hip arthroplasty (THA) in patients with end-stage arthritis of the hip is associated with preoperative physical status. This study was performed to examine the relationship between the preoperative severity of sarcopenia and clinical outcomes after THA. This retrospective cohort study was performed among 306 consecutive patients (mean age: 63.7 ± 12.9 years, 222 women) undergoing THA at a university hospital. The severity of sarcopenia was determined based on the skeletal muscle mass index (SMI), handgrip strength, and gait speed according to the criteria of the Asian Working Group for Sarcopenia 2019. The severe sarcopenia prevalence rate was 10.6%. Severe sarcopenia was significantly associated with the risk of delayed functional recovery (adjusted odds ratio, 2.82; 95% confidence interval, 1.03–7.72; p = 0.043) compared with the non-sarcopenia group after adjusting for pre-existing risk factors, including preoperative hip function and physical activity. The addition of SMI, handgrip strength, and gait speed to the model for risk of functional recovery delay significantly increased the area under the receiver operating characteristic curve (p = 0.038). Severe sarcopenia was significantly associated with poorer hip function and patient-reported outcomes at 6 months after surgery compared with the non-sarcopenia group. Severe sarcopenia was adversely associated with postoperative clinical outcomes in patients undergoing THA.

DOI： 10.3390/nu16132085

Tanaka, K; Machida, R; Endo, M; Kawai, A; Nakayama, R; Tsukushi, S; Asanuma, K; Hiraga, H; Hiraoka, K; Yoshida, S; Yonemoto, T; Imanishi, J; Katagiri, H; Nishida, Y; Nagano, A; Sekino, Y; Fukuda, H; Ozaki, T; Iwamoto, Y

JOURNAL OF CLINICAL ONCOLOGY Vol. 42 ( 16 ) 2024.6

Hand Grip Strength Assessment Based on Sarcopenia Diagnostic Criteria Predicts Swallowing Function Reviewed

Okada, T; Yamaguchi, H; Tanaka, S; Koyama, K; Hishida, A; Konno, S; Nakamura, M; Sugiura, H; Nishida, Y

DYSPHAGIA Vol. 39 ( 2 ) page： 223 - 230 2024.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Dysphagia

The purpose of this study is to clarify whether swallowing function can be inferred from grip strength. Based on the diagnostic criteria of sarcopenia, patients were divided into two groups according to grip strength, and it was analyzed whether there was a difference in the evaluation index for swallowing function between the two groups. Among the cases requesting evaluation of swallowing function from June 10, 2020 to October 28, 2020, 83 cases (mean age: 71.7 years, 59 males and 24 females) who received assessment tests and swallowing endoscopy were included. According to the diagnostic criteria for grip strength in the Asian working group in Sarcopenia, less than 28 kgf and 18 kgf were defined as the weak group for men and women, respectively. Hyodo scores, repeated salivary swallowing tests (RSST), maximum vocalization time (MPT), and dysphagia severity classification (DSS) were compared between the two groups. Of the 83 patients, 29 and 54 were in the normal group and weak group, respectively. In all indicators, the normal group showed significantly better results than the weak group: Hyodo score (2.4 vs. 4.0, p < 0.01), RSST (4.1 times vs. 2.4 times, p < 0.01), MPT (12.1 s vs. 5.9 s, p < 0.001), DSS (4.5 vs. 5.9, p < 0.001), respectively. In multiple regression analysis with DSS as the dependent variable, grip strength was a significant independent variable of DSS even after adjusting for age, gender, and body mass index. Grip strength assessment based on sarcopenia criteria can be a useful tool for estimating swallowing function.

DOI： 10.1007/s00455-023-10604-y