Faculty Profiles - NISHIDA, Yoshihiro

Papers - NISHIDA, Yoshihiro

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Feasibility and effects of a self-assembling peptide as a scaffold in bone healing: An in vivo study in rabbit lumbar posterolateral fusion and tibial intramedullary models Reviewed Open Access

Ando, K; Imagama, S; Kobayashi, K; Ito, K; Tsushima, M; Morozumi, M; Tanaka, S; Machino, M; Ota, K; Nishida, K; Nishida, Y; Ishiguro, N

JOURNAL OF ORTHOPAEDIC RESEARCH Vol. 36 ( 12 ) page： 3285 - 3293 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Orthopaedic Research

Spinal fusion and bone defects after injuries, removal of bone tumors, and infections require repair by implantation. In this study, we show self-assembling peptide (SPG-178) hydrogel-induced bone healing in vivo. Posterolateral lumbar fusion and tibial intramedullary models of rabbits were prepared. In the tibia model, micro-CT analysis revealed a significantly higher degree of newly formed bone matrix in the SPG-178 group compared to the other groups. SEM/3D micrographs showed that the cavity filled with SPG-178 had collagen fibers attached to host bone. After 28 days, samples from the SPG-178 group showed significant repair of the defect. In the posterolateral lumbar fusion models, micro-CT showed a tendency for a higher degree of newly formed bone matrix in the SPG-178 group compared to the β-TCP and bone chips only groups. Von Kossa staining showed marked new bone formation attached to the lamina that was most prominent at the implanted SPG-178 composite margin. SPG-178 is a material that is likely to be used in clinical applications because it has several benefits. These include its favorable bone conduction properties, its ability to act as a support for various cells and growth factors, its lack of infection risk compared with materials of animal origin such as ECM, and the ease with which it can be used to fill defects with complex shapes and be combined with a wide range of other materials. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3285–3293, 2018.

DOI： 10.1002/jor.24109

Web of Science

Scopus

PubMed

Postoperative Complications Associated With Spine Surgery in Patients Older Than 90 Years: A Multicenter Retrospective Study Reviewed Open Access

Kobayashi, K; Imagama, S; Sato, K; Kato, F; Kanemura, T; Yoshihara, H; Sakai, Y; Shinjo, R; Hachiya, Y; Osawa, Y; Matsubara, Y; Ando, K; Nishida, Y; Ishiguro, N

GLOBAL SPINE JOURNAL Vol. 8 ( 8 ) page： 887 - 891 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Global Spine Journal

Study Design: A review of a prospective database. Objectives: Surgery for elderly patients is increasing yearly due to aging of society and the desire for higher quality of life. The goal of the study was to examine perioperative complications in spine surgery in such patients. Methods: A multicenter study of surgical details and perioperative complications was performed in 35 patients aged older than 90 years who underwent spinal surgery, based on a review of a prospective database. The frequency and severity of complications were assessed, and the effects of patient-specific and surgical factors were examined. Major complications were defined as those that were life threatening, required reoperation in the perioperative period or left a permanent injury. Ambulatory function before and after surgery was also analyzed. Results: Perioperative complications occurred in 19 of the 35 cases (54%), and included 11 cases of postoperative delirium, most of which occurred after cervical spine surgery. There were 8 major complications (23%), including cerebral infarction (n = 3), coronary heart disease (n = 3), pulmonary embolism (n = 1), and angina (n = 1). Preoperative motor deficit, operative time, estimated blood loss, and instrumented fusion were significantly associated with major complications. An improved postoperative ambulatory status occurred in 61% of cases, with no change in 33%, and worsening in 2 cases (6%). Conclusions: Timing of surgery before paralysis progression and reduced surgical invasiveness are important considerations in treatment of the very elderly. Improved outcomes can be obtained with better management of spine surgery for patients aged 90 years or older.

DOI： 10.1177/2192568218767430

Serum cystatin C level is associated with locomotive syndrome risk and can be an early predictor in community-living people: The Yakumo study. Reviewed Open Access

Tanaka S, Ando K, Kobayashi K, Hida T, Ito K, Tsushima M, Morozumi M, Machino M, Ota K, Seki T, Suzuki K, Nishida Y, Ishiguro N, Hasegawa Y, Imagama S

Modern rheumatology Vol. 28 ( 6 ) page： 1035 - 1040 2018.11

Atypical vertebral column fracture at the middle of fused area after instrumented posterior decompression and fusion surgery for beak type thoracic ossification of the posterior longitudinal ligament Reviewed

Imagama, S; Ando, K; Kobayashi, K; Hida, T; Ito, K; Tsushima, M; Ishikawa, Y; Matsumoto, A; Nishida, Y; Ishiguro, N

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 23 ( 6 ) page： 1100 - 1104 2018.11

A randomized phase III study of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group study JCOG1610 Reviewed

Urakawa, H; Mizusawa, J; Tanaka, K; Eba, J; Hiraga, H; Hosaka, M; Kawai, A; Nakatani, F; Kobayashi, E; Nishida, Y; Okamoto, T; Matsunobu, T; Iwamoto, Y; Fukuda, H; Ozaki, T

ANNALS OF ONCOLOGY Vol. 29 2018.10

Outpatient chemotherapy for patients with unresectable or metastatic bone sarcomas Reviewed

Urakawa, H; Nishida, Y; Mitsuma, A; Maeda, O; Sugishita, M; Shimokata, T; Mizutani, T; Arai, E; Ikuta, K; Hamada, S; Ota, T; Ishiguro, N; Ando, Y

ANNALS OF ONCOLOGY Vol. 29 2018.10

A case report; Surgery and rehabilitation for spinal canal stenosis in achondroplasia Reviewed

HISHIDA Aika

The Central Japan Journal of Orthopaedic Surgery & Traumatology Vol. 61 ( 5 ) page： 963 - 964 2018.9

Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study Reviewed Open Access

Urakawa, H; Yonemoto, T; Matsumoto, S; Takagi, T; Asanuma, K; Watanuki, M; Takemoto, A; Naka, N; Matsumoto, Y; Kawai, A; Kunisada, T; Kubo, T; Emori, M; Hiraga, H; Hatano, H; Tsukushi, S; Nishida, Y; Akisue, T; Morii, T; Takahashi, M; Nagano, A; Yoshikawa, H; Sato, K; Kawano, M; Hiraoka, K; Tanaka, K; Iwamoto, Y; Ozaki, T

WORLD JOURNAL OF SURGICAL ONCOLOGY Vol. 16 ( 1 ) page： 160 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：World Journal of Surgical Oncology

Background: Giant cell tumor of bone (GCTB) is an intermediate tumor known to be locally aggressive, but rarely metastasizing. To plan a prospective study of GCTB, we performed a questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) in the Japan Clinical Oncology Group (JCOG) in 2015. Methods: We reviewed 158 consecutive patients with primary GCTB treated with curettage without perioperative denosumab from 2008 to 2010 in Japan. We investigated local and distant recurrence rates after definitive curettage. We also investigated the recurrence rate after treatment with preoperative and/or postoperative denosumab with curettage in recent years. There were 40 patients treated with perioperative denosumab, and the factors affecting recurrence in them were investigated. Results: Answers were available from 24 of 30 institutions (80.0%) participating in JCOG BSTTSG. Thirty (19.0%) and 4 (2.5%) of 158 patients developed local and distant recurrence after curettage without perioperative denosumab from 2008 to 2010, respectively. Campanacci grade and embolization before surgery were significantly associated with increasing incidence of local recurrence after curettage (p=0.034 and p=0.022, respectively). In patients treated with perioperative desnosumab, 120mg denosumab was administered subcutaneously for a median 6 (2-41) and 6 (1-14) times in preoperative and postoperative settings, respectively. The recurrence rates were 6 of 21 (28.6%), 2 of 9 (22.2%), and 0 of 10 (0.0%) in the preoperative, postoperative, and both pre- and postoperative denosumab treatment groups, respectively. With all of the preoperative treatments, administration exceeding five times was significantly associated with a decreased incidence of local recurrence after curettage (p<0.001). Conclusion: The recurrence rate of GCTB was still high after curettage, especially in Campanacci grade III, and improvements in the therapeutic strategy are needed in this cohort. There is a possibility that a sufficient dose of preoperative denosumab can reduce recurrence after curettage. Recently, we have started a clinical trial, JCOG1610, to investigate the efficacy of preoperative denosumab in patients who can be treated with curettage in GCTB.

DOI： 10.1186/s12957-018-1459-6

Epidemiological trends in spine surgery over 10 years in a multicenter database Reviewed

Kobayashi, K; Ando, K; Nishida, Y; Ishiguro, N; Imagama, S

EUROPEAN SPINE JOURNAL Vol. 27 ( 8 ) page： 1698 - 1703 2018.8

Reoperation within 2 years after lumbar interbody fusion: a multicenter study Reviewed

Kobayashi, K; Ando, K; Kato, F; Kanemura, T; Sato, K; Hachiya, Y; Matsubara, Y; Kamiya, M; Sakai, Y; Yagi, H; Shinjo, R; Nishida, Y; Ishiguro, N; Imagama, S

EUROPEAN SPINE JOURNAL Vol. 27 ( 8 ) page： 1972 - 1980 2018.8

Effect of postoperative doxorubicin administration on ischemic wound healing Reviewed Open Access

Morishita, T; Toriyama, K; Takanari, K; Yagi, S; Ebisawa, K; Hishida, M; Narita, Y; Osaga, S; Nishida, Y; Kamei, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 3 ) page： 357 - 366 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Nagoya Journal of Medical Science

Some patients undergo postoperative chemotherapy despite showing impaired wound healing after a major surgery. We speculated that postoperative chemotherapy further delays wound healing in these patients. This study aimed to compare the effects of doxorubicin (DXR) in ischemic skin flap and normal incisional wound models after surgery. A 2-cm incisional wound was made in group 1 rats, and saline was injected intravenously, following surgery on the same day. Incisional wound was made in group 2-5 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. H-shaped double flaps were made in group 6 rats, and saline was injected intravenously, following surgery on the same day. Flaps were made in group 7-10 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. On days 7, 14, 21, and 28 after surgery, the suture wounds were removed, tensile wound strengths were measured, and tissue samples were collected for histopathological evaluation. The tensile strength was significantly lower in the DXR-treated groups than in the control groups for both ischemic skin flaps and incision wounds. Additionally, the cross effect between DXR and ischemia was not significant. On pathological examination, DXR showed atrophic skin changes and degeneration of skin appendages on days 14-21 after the surgery in both the models. DXR decreased the wound tensile strength and caused an atrophic change in the ischemic wound.

DOI： 10.18999/nagjms.80.3.357

Surgical intervention for a pediatric isolated intramedullary spinal aneurysm. Reviewed

Morozumi M, Imagama S, Ando K, Kobayashi K, Hida T, Ito K, Tsushima M, Matsumoto A, Tanaka S, Machino M, Ota K, Nishida Y, Ishiguro N

Eur Spine J. Vol. 27 ( Suppl 3 ) page： 342 - 346 2018.7

Surgical outcomes of spinal cord and cauda equina ependymoma: Postoperative motor status and recurrence for each WHO grade in a multicenter study. Reviewed Open Access

Kobayashi K, Ando K, Kato F, Kanemura T, Sato K, Kamiya M, Nishida Y, Ishiguro N, Imagama S

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Vol. 23 ( 4 ) page： 614 - 621 2018.7

The Feature of Clinical and Radiographic Outcomes in Elderly Patients with Cervical Spondylotic Myelopathy: A Prospective Cohort Study on 1025 Patients. Reviewed

Machino M, Imagama S, Ando K, Kobayashi K, Ito K, Tsushima M, Matsumoto A, Morozumi M, Tanaka S, Ito K, Kato F, Nishida Y, Ishiguro N

Spine Vol. 43 ( 12 ) page： 817 - 823 2018.6

Predictors of complications in heat-treated autograft reconstruction after intercalary resection for malignant musculoskeletal tumors of the extremity. Reviewed

Ikuta K, Nishida Y, Sugiura H, Tsukushi S, Yamada K, Urakawa H, Arai E, Hamada S, Ishiguro N

Journal of surgical oncology Vol. 117 ( 7 ) page： 1469 - 1478 2018.6

Suppression of hyaluronan synthesis attenuates the tumorigenicity of low-grade chondrosarcoma. Reviewed Open Access

Hamada S, Nishida Y, Zhuo L, Shinomura T, Ikuta K, Arai E, Koike H, Kimata K, Ushida T, Ishiguro N

Journal of orthopaedic research : official publication of the Orthopaedic Research Society Vol. 36 ( 6 ) page： 1573 - 1580 2018.6

Analysis of the Infiltrative Features of Chordoma: The Relationship Between Micro-Skip Metastasis and Postoperative Outcomes Reviewed

Akiyama Toru, Ogura Koichi, Gokita Tabu, Tsukushi Satoshi, Iwata Shintaro, Nakamura Tomoki, Matsumine Akihiko, Yonemoto Tsukasa, Nishida Yoshihiro, Saita Kazuo, Kawai Akira, Matsumoto Seiichi, Yamaguchi Takehiko

ANNALS OF SURGICAL ONCOLOGY Vol. 25 ( 4 ) page： 912 - 919 2018.4

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification Reviewed

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Ishii Takeaki, Nishida Yoshihiro, Urakawa Hiroshi, Ito Ichiro, Takahashi Mitsuru, Inoue Takeshi, Ito Masafumi, Ohara Yuuki, Oda Yoshinao, Toyokuni Shinya

HISTOPATHOLOGY Vol. 72 ( 5 ) page： 729 - 738 2018.4

Single metastasis of myxoid liposarcoma from the thigh to thyroid gland: a case report Reviewed Open Access

Urakawa Hiroshi, Nakanishi Kenichi, Arai Eisuke, Ikuta Kunihiro, Hamada Shunsuke, Ota Takehiro, Ishiguro Naoki, Nishida Yoshihiro

WORLD JOURNAL OF SURGICAL ONCOLOGY Vol. 16 ( 1 ) page： 71 2018.3

Image Diagnostic Classification of Magnetic Resonance T2 Increased Signal Intensity in Cervical Spondylotic Myelopathy: Clinical Evaluation Using Quantitative and Objective Assessment. Reviewed

Machino M, Imagama S, Ando K, Kobayashi K, Ito K, Tsushima M, Matsumoto A, Morozumi M, Tanaka S, Ito K, Kato F, Nishida Y, Ishiguro N

Spine Vol. 43 ( 6 ) page： 420 - 426 2018.3

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Papers - NISHIDA, Yoshihiro