Faculty Profiles - TOYOKUNI Shinya

Papers - TOYOKUNI Shinya

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The 4-hydroxy-2-nonenal-derived fluorescent pigment International journal

Uchida, K; Itakura, K; Oya-Ito, T; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S100 - S100 1999

The malondialdehyde-derived fluorescent pigment International journal

Uchida, K; Sakamoto, S; Itakura, K; Kumazawa, S; Nakayama, T; Toyokuni, S; Osawa, T

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S100 - S100 1999

Detection of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1 and its application

Toyokuni, S

ADVANCES IN DNA DAMAGE AND REPAIR Vol. 302 page： 395 - 405 1999

Oxidative stress in the human stomach infected with <i>Helicobacter pylori</i>:: effect of bacterial eradication

Pignatelli, B; Li, CQ; Bancel, B; Toyokuni, S; Ohshima, H

2ND INTERNATIONAL CONGRESS ON GASTROENTEROLOGICAL CARCINOGENESIS page： 39 - 42 1999

Iron chelators modulate the production of DNA strand breaks and 8-hydroxy-2 '-deoxyguanosine

Toyokuni S, Sagripanti JL

FREE RADICAL RESEARCH Vol. 31 ( 2 ) page： 123 - 128 1999

hOGG1 overexpression and high 8-Oxo-2'-deoxyguanosine lyase activity in human colorectal carcinoma

Toyokuni, S; Kondo, S; Tanaka, T; Hiai, H; Onodera, H; Imamura, M

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S149 - S149 1999

Association between M/L55-polymorphism of paraoxonase enzyme and oxidative DNA damage in patients with type 2 diabetes mellitus and in control subjects

Malin R, Rantalaiho V, Huang XH, Wirta O, Pasternack A, Leinonen JS, Alho H, Jokela H, Koivula T, Tanaka T, Okada K, Ochi H, Toyokuni S, Lehtimaki T

HUMAN GENETICS Vol. 105 ( 1-2 ) page： 179 - 180 1999

Spuamous Cell Carcinoma in Thyroid Papillary Carcinoma International journal Open Access

MINAMINO Masayuki, TSUJI Hiroyuki, NAKAMURA Akihiko, INOUE Toshiya, OHNISHI Sumio, HUJISAWA Takuo, YAMASHITA Toshio, TOYOKUNI Shinya

Practica Oto-Rhino-Laryngologica Vol. 92 ( 3 ) page： 283 - 286 1999

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Society of Practical Otolaryngology

We report the case of a 62-year-old man with a Squamous cell carcinoma of the thyroid gland which had invaded the hypopharynx. Primary squamous cell carcinoma of the thyroid gland is extremely rare. Its clinical course is very aggressive and the prognosis is poor. The patient underwent a radical resection of the thyroid, hypopharynx, larynx and resection of the trachea and esophagus was conducted concomitantly with bilateral neck dissection. Reconstruction of the terminal tracheostomy in the anterior mediastinum was created using a pectoralis major muscle flap.

DOI： 10.5631/jibirin.92.283

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The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2'-deoxyguanosine in arsenic-related Bowen's disease

Matsui M., Nishigori C., Toyokuni S., Takada J., Akaboshi M., Ishikawa M., Imamura S., Miyachi Y.

Journal of Investigative Dermatology Vol. 113 ( 1 ) page： 26 - 31 1999

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Investigative Dermatology

Arsenic is widely distributed in nature in the form of either metalloids or chemical compounds, which cause a variety of pathologic conditions including cutaneous and visceral malignancies. Recently, reactive oxygen species have been hypothesized to be one of the causes of arsenic-induced carcinogenesis. 8-Hydroxy-2'-deoxyguanosine is one of the major reactive oxygen species-induced DNA base-modified products that is widely accepted as a sensitive marker of oxidative DNA damage. We studied the presence of 8- hydroxy-2'-deoxyguanosine by immunohistochemistry using N45.1 monoclonal antibody in 28 cases of arsenic-related skin neoplasms and arsenic keratosis as well as in 11 cases of arsenic-unrelated Bowen's diseases. The frequency of 8-hydroxy-2'-deoxyguanosine positive cases was significantly higher in arsenic-related skin neoplasms (22 of 28; 78%) than in arsenic-unrelated Bowen's disease (one of 11; 9%) (p < 0.001 by χ2 test). 8-Hydroxy-2'- deoxyguanosine was also detected in normal tissue adjacent to the arsenic- related Bowen's disease lesions. Furthermore, arsenic was detected by neutron activation analysis in the deparaffined skin tumor samples of arsenic- related disease (four of five; 80%), whereas arsenic was not detected in control samples. Our results strongly suggest the involvement of reactive oxygen species in arsenic-induced human skin cancer.

DOI： 10.1046/j.1523-1747.1999.00630.x

Scopus

The 4-hydroxy-2-nonenal-derived fluorescent pigment International journal

Uchida, K, Itakura, K, Oya-Ito, T, Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S100 - S100 1999

The malondialdehyde-derived fluorescent pigment International journal

Uchida, K, Sakamoto, S, Itakura, K, Kumazawa, S, Nakayama, T, Toyokuni, S, Osawa, T

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S100 - S100 1999

Oxidative stress in the human stomach infected with Helicobacter pylori: effect of bacterial eradication International journal

Pignatelli B, Li CQ, Bancel B, Toyokuni S, Ohshima H

2ND INTERNATIONAL CONGRESS ON GASTROENTEROLOGICAL CARCINOGENESIS page： 39 - 42 1999

Iron chelators modulate the production of DNA strand breaks and 8-hydroxy-2 '-deoxyguanosine

Toyokuni S, Sagripanti JL

FREE RADICAL RESEARCH Vol. 31 ( 2 ) page： 123 - 128 1999

hOGG1 overexpression and high 8-Oxo-2'-deoxyguanosine lyase activity in human colorectal carcinoma International journal

Toyokuni, S, Kondo, S, Tanaka, T, Hiai, H, Onodera, H, Imamura, M

FREE RADICAL BIOLOGY AND MEDICINE Vol. 27 page： S149 - S149 1999

Hyperglycemia causes oxidative stress in pancreatic β-cells of GK rats, a model of type 2 diabetes

Ihara Y., Toyokuni S., Uchida K., Odaka H., Tanaka T., Ikeda H., Hiai H., Seino Y., Yamada Y.

Diabetes Vol. 48 ( 4 ) page： 927 - 932 1999

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Diabetes

Reactive oxygen species are involved in a diversity of biological phenomena such as inflammation, carcinogenesis, aging, and atherosclerosis. We and other investigators have shown that the level of 8-hydroxy-2'- deoxyguanosine (8-OHdG), a marker for oxidative stress, is increased in either the urine or the mononuclear cells of the blood of type 2 diabetic patients. However, the association between type 2 diabetes and oxidative stress in the pancreatic β-cells has not been previously described. We measured the levels of 8-OHdG and 4-hydroxy-2-nonenal (HNE)-modified proteins in the pancreatic β-cells of GK rats, a model of nonobese type 2 diabetes. Quantitative immunohistochemical analyses with specific antibodies revealed higher levels of 8-OHdG and HNE-modified proteins in the pancreatic β-cells of GK rats than in the control Wistar rats, with the levels increasing proportionally with age and fibrosis of the pancreatic islets. We further investigated whether the levels of 8-OHdG and HNE-modified proteins would be modified in the pancreatic β-cells of GK rats fed with 30% sucrose solution or 50 ppm of voglibose (α-glucosidase inhibitor). In the GK rats, the levels of 8-OHdG and HNE-modified proteins, as well as islet fibrosis, were increased by sucrose treatment but reduced by voglibose treatment. These results indicate that the pancreatic β-cells of GK rats are oxidatively stressed, and that chronic hyperglycemia might be responsible for the oxidative stress observed in the pancreatic β-cells.

DOI： 10.2337/diabetes.48.4.927

Scopus

Detection of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1 and its application International journal

Toyokuni, S

ADVANCES IN DNA DAMAGE AND REPAIR Vol. 302 page： 395 - 405 1999

Association between M/L55-polymorphism of paraoxonase enzyme and oxidative DNA damage in patients with type 2 diabetes mellitus and in control subjects

Malin R, Rantalaiho V, Huang XH, Wirta O, Pasternack A, Leinonen JS, Alho H, Jokela H, Koivula T, Tanaka T, Okada K, Ochi H, Toyokuni S, Lehtimaki T

HUMAN GENETICS Vol. 105 ( 1-2 ) page： 179 - 180 1999

Oxidative stress in the human stomach infected with <i>Helicobacter pylori</i>:: effect of bacterial eradication International journal

Pignatelli, B, Li, CQ, Bancel, B, Toyokuni, S, Ohshima, H

2ND INTERNATIONAL CONGRESS ON GASTROENTEROLOGICAL CARCINOGENESIS page： 39 - 42 1999

A study of imprint smear cytology during surgery of mucinous cystic tumor of ovary : A special reference to borderline malignancy

SHIMIZU Keiko, OGURA Seiko, MURATA Masayoshi, TAKAO Yumi, TOYOKUNI Shinya, SAKURAI Masami

The Journal of the Japanese Society of Clinical Cytology Vol. 37 ( 6 ) page： 583 - 590 1998.11

A study of imprint smear cytology during surgery of mucinous cystic tumor of ovary : A special reference to borderline malignancy

SHIMIZU Keiko, OGURA Seiko, MURATA Masayoshi, TAKAO Yumi, TOYOKUNI Shinya, SAKURAI Masami

The Journal of the Japanese Society of Clinical Cytology Vol. 37 ( 6 ) page： 583 - 590 1998.11

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