Faculty Profiles - TOYOKUNI Shinya

Papers - TOYOKUNI Shinya

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Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status. Reviewed International journal

Yamashita K, Kohashi K, Yamada Y, Nishida Y, Urakawa H, Oda Y, Toyokuni S

Human Pathology Vol. 63 page： 63-69 2017.2

Cancer and trace metal element

Vol. 61 ( 2 ) page： 168 - 173 2017.2

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Reviewed

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.

Free Radical Biology & Medicine Vol. 106 page： 91-99 2017.2

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Reviewed International journal

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S

Free Radical Biology & Medicine Vol. 106 page： 91-99 2017.2

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Oda Yoshinao, Toyokuni Shinya

MODERN PATHOLOGY Vol. 30 page： 27A-27A 2017.2

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Oda Yoshinao, Toyokuni Shinya

LABORATORY INVESTIGATION Vol. 97 page： 27A - 27A 2017.2

Clinicopathological and Molecular Features of Dedifferentiated Liposarcoma with Ossification: A Comparative Study with Dedifferentiated Liposarcoma without Ossification and Extraskeletal Osteosarcoma International journal

Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshinao Oda, Shinya Toyokuni

LABORATORY INVESTIGATION Vol. 97 page： 27A - 27A 2017.2

Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshinao Oda, Shinya Toyokuni

MODERN PATHOLOGY Vol. 30 page： 27A - 27A 2017.2

Future perspective of strategic non-thermal plasma therapy for cancer treatment.

Hiroaki Kajiyama, Fumi Utsumi, Kae Nakamura, Hiromasa Tanaka, Shinya Toyokuni, Masaru Hori, Fumitaka Kikkawa

Journal of clinical biochemistry and nutrition Vol. 60 ( 1 ) page： 33 - 38 2017.1

Language：English Publishing type：Research paper (scientific journal) Publisher：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

The therapeutic effects of non-thermal plasma are expected in the medical fields, including hemostasis, vascularization, prevention of organ adhesion, and cell proliferation. Cancer is an internal enemy arising from normal tissue in the body. The prognosis of metastatic and recurrent cancers is still poor despite advances in medicine. To apply non-thermal plasma in cancer treatment is now on going. The mechanism of the proliferation-inhibitory effect of plasma is reactive nitrogen oxide species/reactive oxygen species production in cells. There are a number of problems to be overcome, such as existence of intrinsic reactive oxygen species/reactive nitrogen species scavengers and the shallow infiltration of plasma on tumor surface. The current reviews makes referral to the study results of plasma therapy clarified so far, the possibility of its application in the future.

DOI： 10.3164/jcbn.16-65

Primary cause of carcinogenesis: what toxicology can contribute

TOYOKUNI Shinya

Annual Meeting of the Japanese Society of Toxicology Vol. 44 ( 0 ) page： S11 - S11 2017

がんと微量金属元素 (Cancer and trace metal element)

伊藤文哉, 豊國伸哉

臨床検査Journal of clinical laboratory medicine Vol. 61 2017

がんと微量金属元素 (Cancer and trace metal element) International journal

伊藤文哉, 豊國伸哉

臨床検査Journal of clinical laboratory medicine Vol. 61 2017

Future perspective of strategic non-thermal plasma therapy for cancer treatment. Reviewed

Kajiyama H, Utsumi F, Nakamura K, Tanaka H, Toyokuni S, Hori M, Kikkawa F.

Journal of Clinical Biochemistry and Nutrition Vol. 60 ( 1 ) page： 33-38 2016.12

Future perspective of strategic non-thermal plasma therapy for cancer treatment. Reviewed International journal

Kajiyama H, Utsumi F, Nakamura K, Tanaka H, Toyokuni S, Hori M, Kikkawa F

Journal of Clinical Biochemistry and Nutrition Vol. 60 ( 1 ) page： 33-38 2016.12

Editorial: The cutting edge of zinc biology. International journal

Taiho Kambe, Toshiyuki Fukada, Shinya Toyokuni

Archives of biochemistry and biophysics Vol. 611 page： 1 - 2 2016.12

The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology. International journal

Cahill MA, Jazayeri JA, Catalano SM, Toyokuni S, Kovacevic Z, Richardson DR

Biochimica et biophysica acta Vol. 1866 ( 2 ) page： 339 - 349 2016.12

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed International journal

Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, Yumiko Ito, Hua Li, Yukio Mano, Jingwen Wang, Rika Miki, Eiko Yamamoto, Akira Iwase, Yasuko K Bando, Masaaki Hirayama, Kinji Ohno, Shinya Toyokuni, Fumitaka Kikkawa

Free radical biology & medicine Vol. 101 ( 16 ) page： 524 - 533 2016.12

Language：English Publishing type：Research paper (scientific journal)

Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclampsia. H2 water (HW) was administered orally ad libitum in RUPP rats from gestational day (GD) 12-19, starting 2 days before RUPP procedure. On GD19, mean arterial pressure (MAP) was measured, and samples were collected. Maternal administration of HW significantly decreased MAP, and increased fetal and placental weight in RUPP rats. The increased levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and diacron reactive oxygen metabolites as a biomarker of reactive oxygen species in maternal blood were decreased by HW administration. However, vascular endothelial growth factor level in maternal blood was increased by HW administration. Proteinuria, and histological findings in kidney were improved by HW administration. In addition, the effects of H2 on placental villi were examined by using a trophoblast cell line (BeWo) and villous explants from the placental tissue of women with or without preeclampsia. H2 significantly attenuated hydrogen peroxide-induced sFlt-1 expression, but could not reduce the expression induced by hypoxia in BeWo cells. H2 significantly attenuated sFlt-1 expression in villous explants from women with preeclampsia, but not affected them from normotensive pregnancy. The prophylactic administration of H2 attenuated placental ischemia-induced hypertension, angiogenic imbalance, and oxidative stress. These results support the theory that H2 has a potential benefit in the prevention of preeclampsia.

DOI： 10.1016/j.freeradbiomed.2016.10.491

Preclinical Use of CTGF-Specific Monoclonal Antibody for the Treatment of Malignant Mesothelioma International journal

Ohara, Y; Wang, SQ; Jiang, L; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE Vol. 100 page： S127 - S127 2016.11

Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Reviewed International journal

Shenqi Wang, Li Jiang, Yipeng Han, Shan Hwu Chew, Yuuki Ohara, Shinya Akatsuka, Liang Weng, Koji Kawaguchi, Takayuki Fukui, Yoshitaka Sekido, Kohei Yokoi, Shinya Toyokuni

Oncotarget Vol. 7 ( 43 ) page： 69565 - 69578 2016.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Impact Journals LLC

Malignant mesothelioma (MM) is a rare neoplasm associated with asbestos exposure. The prognosis of MM is poor because it is aggressive and highly resistant to chemotherapy. Using a rat model of asbestos-induced MM, we found elevated urokinase-type plasminogen activator receptor (uPAR
Plaur) expression in rat tissues, which was associated with poor prognosis. The proliferation, migration and invasion of MM cells were suppressed by uPAR knockdown and increased by overexpression experiments, irrespective of urokinase-type plasminogen activator (uPA
Plau) levels. More importantly, we found that uPAR expression is associated with sensitivity to cisplatin in MM through the PI3K/AKT pathway, which was demonstrated with specific inhibitors, LY294002 and Akti-1/2. uPAR knockdown significantly increased sensitivity to cisplatin whereas its overexpression significantly decreased cisplatin sensitivity. Furthermore, sera and tissues from MM patients showed significantly high uPAR levels, which suggested the pathogenic role of uPAR in the tumor biology of human MM. In conclusion, our findings indicate that uPAR levels are associated with malignant characteristics and cisplatin sensitivity of MM. In addition to the potential use of uPAR as a prognostic marker, the combination of uPAR abrogation and cisplatin may reveal a promising therapeutic approach for MM.

DOI： 10.18632/oncotarget.11829

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.

Free Radic Biol Med. Vol. pii: S0891-5849 ( 16 ) page： 30978-9. 2016.10

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Papers - TOYOKUNI Shinya