Faculty Profiles - TOYOKUNI Shinya

Papers - TOYOKUNI Shinya

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Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma International journal

Kurake Naoyuki, Ishikawa Kenji, Tanaka Hiromasa, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Toyokuni Shinya, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 662 page： 83 - 92 2019.2

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.

Funahashi S, Okazaki Y, Nagai H, Chew SH, Ogawa K, Toyoda T, Cho YM, Toyokuni S

Journal of toxicologic pathology Vol. 32 ( 1 ) page： 19-26 2019.1

Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner Reviewed International journal

Kotaro Sato, Lei Shi, Fumiya Ito, Yuuki Ohara, Yashiro Motooka, Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori, Tasuku Hirayama, Hideharu Hibi, Shinya Toyokuni

Journal of Clinical Biochemistry and Nutrition Vol. 65 ( 4 ) page： 8 - 15 2019

Iron Metabolism and Ferroptosis Reviewed International journal

Toyokuni Shinya, Yanatori Izumi

FERROPTOSIS IN HEALTH AND DISEASE page： 27 - 41 2019

A scrutiny of circulating microRNA biomarkers for tubular and glomerular injury in rats

KAGAWA Takumi, ZÁRYBNICKÝ Tomáš, OMI Takanao, SHIRAI Yuji, TOYOKUNI Shinya, ODA Shingo, YOKOI Tsuyoshi

Annual Meeting of the Japanese Society of Toxicology Vol. 46 ( 0 ) page： P - 233 2019

Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Toxicology

[Introduction] Drug-induced acute kidney injury (AKI) is a frequent cause of adverse drug reaction. Serum creatinine (CRE) and blood urea nitrogen (BUN) are widely used as standard biomarkers for kidney injury; however, the sensitivity and specificity are considered to be low. In recent years, circulating microRNA (miRNAs) have been attracting considerable attention as novel biomarkers for organ injury, but there are currently no established miRNA biomarkers for drug-induced AKI. The present study aimed to identify plasma miRNAs that may enable early and specific detection of drug-induced tubular and glomerular injury through next-generation sequencing analysis. [Methods] Six-week old male Sprague-Dawley rats were administered cisplatin and gentamicin to induce tubular injury. To create glomerular injury models, puromycin and doxorubicin were administered, and these models were always accompanied by tubular damage. Small RNA-sequencing was performed to analyze time-dependent changes in the plasma miRNA profiles. [Results and Discussion] In the differential analysis, miR-3473 was specifically up-regulated in the glomerular injury models. miR-143-3p and miR-122-5p were commonly down-regulated in all models, and the changes were earlier than the traditional biomarkers, such as plasma CRE and BUN. These data indicated that changes in the specific miRNAs in plasma may enable the early and sensitive detection of tubular and glomerular injuries. The present study suggests the potential utility of plasma miRNAs in the early and type-specific detection of drug-induced AKI.

DOI： 10.14869/toxpt.46.1.0_P-233

Chemiluminescence imaging of UVA induced reactive oxygen species in mouse skin using L-012 as a probe International journal

Liu Jiao-Li, Xue Qiao, Liu Chen-Guang, Bai Feng-Wu, Wada Satoshi, Wang Jin-Ye

FREE RADICAL RESEARCH Vol. 52 ( 11-12 ) page： 1424 - 1431 2018.12

Asbestos exposure as a possible cause of ovarian carcinogenesis

Yashiro Motooka, Ito Fumiya, Tashiro Hironori, Katabuchi Hidetaka, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 255-255 2018.12

Analysis of the involvement of cancer-associated fibroblasts in the progression of malignant mesothelioma

Ohara Yuuki, Enomoto Atsushi, Takahashi Masahide, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 454-454 2018.12

Critical role of Hippo signaling pathway at the onset of squamous cell carcinomas

Suzuki Akira, Nishio Miki, Omori Hirofumi, To Yoko, Maehama Tomohiko, Aono Yukari, Kiyono Tohru, Taguchi Kenichi, Masuda Muneyuki, Toyokuni Shinya, Tashiro Hironori, Katabuchi Hidetaka

CANCER SCIENCE Vol. 109 page： 781-781 2018.12

Multifaceted roles of Ptger2 (Prostaglandin E receptor 2) in asbestos-induced inflammation and malignant mesothelioma

Jiang Li, Akatsuka Shinya, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 830-830 2018.12

Inflammatory microenvironment derived from asbestos increases mutagenesis to repairing mesothelial cell

Ito Fumiya, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 830 - 830 2018.12

Ferroptosis in Cancer Research

Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 195-195 2018.12

Critical role of Hippo signaling pathway at the onset of squamous cell carcinomas International journal

Suzuki Akira, Nishio Miki, Omori Hirofumi, To Yoko, Maehama Tomohiko, Aono Yukari, Kiyono Tohru, Taguchi Kenichi, Masuda Muneyuki, Toyokuni Shinya, Tashiro Hironori, Katabuchi Hidetaka

CANCER SCIENCE Vol. 109 page： 781-781 2018.12

Asbestos exposure as a possible cause of ovarian carcinogenesis International journal

Yashiro Motooka, Ito Fumiya, Tashiro Hironori, Katabuchi Hidetaka, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 255-255 2018.12

Analysis of the involvement of cancer-associated fibroblasts in the progression of malignant mesothelioma International journal

Ohara Yuuki, Enomoto Atsushi, Takahashi Masahide, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 454-454 2018.12

Ferroptosis in Cancer Research International journal

Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 195-195 2018.12

Multifaceted roles of Ptger2 (Prostaglandin E receptor 2) in asbestos-induced inflammation and malignant mesothelioma International journal

Jiang Li, Akatsuka Shinya, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 830-830 2018.12

Inflammatory microenvironment derived from asbestos increases mutagenesis to repairing mesothelial cell International journal

Ito Fumiya, Toyokuni Shinya

CANCER SCIENCE Vol. 109 page： 830-830 - 830 2018.12

Polymer coating on carbon nanotubes into Durobeads is a novel strategy for human environmental safety.

Fumiya Ito, Hideyuki Hisashi, Shinya Toyokuni

Nagoya journal of medical science Vol. 80 ( 4 ) page： 597 - 604 2018.11

Language：English Publishing type：Research paper (scientific journal) Publisher：NAGOYA UNIV, SCH MED

Carbon nanotubes (CNTs) have attracted much business interest in industrial applications due to their high electrical and heat conductivities while being both durable and versatile. However. multiwall CNTs (MWCNTs) of similar to 50 nm diameter (NT50) have been shown to cause mesothelioma in rodents after direct exposure to mesothelial cells, and thus were classified as a Group 213 carcinogen to humans, which requires considerable regulations for use. In contrast, tangled MWCNTs of similar to 15 nm diameter (NTtngl) are not carcinogenic to rats, indicating that the physical dimension linked with mesothelial cellular uptake is an important factor for human environmental risk. In the present study, hypothesizing that dustability is another distinct risk factor, for the first time, we evaluated the toxicity of CNT granules (Durobeads) that were generated with a polymer coating to mesothelial cells. Polymer coating induced prominent agglomeration and significantly suppressed the dustability of CNTs in a dose-dependent manner, with a 10% polymer coating resulting in 730 times less dustability. These CNT granules revealed significantly lower mesothelial uptake and cytotoxicity in comparison to NT50 in in vitro assays. Similarly, in in vivo analyses, CNT granules induced limited peritoneal inflammation 4 weeks after intraperitoneal injection, whereas NT50 caused severe fibrosing inflammation. Previously, we demonstrated that the severity of inflammation by intraperitoneal injection in the subacute studies are in agreement with the mesothelial carcinogenicity by CNTs. Therefore, we suggest that adding a polymer coating to CNTs provides another smart strategy for the safe use of CNTs.

DOI： 10.18999/nagjms.80.4.597

Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice.

Funahashi S, Okazaki Y, Nishiyama T, Ohyoshi H, Yasui H, Nishida K, Matsui S, Toyokuni S

Free radical research page： 1-10 2018.10

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Papers - TOYOKUNI Shinya