Faculty Profiles - TOYOKUNI Shinya

Papers - TOYOKUNI Shinya

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Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture.

Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Yoshida S, Toyokuni S, Lee J, Ogura A and Shinohara T.

Biol. Reprod. Vol. 76 page： 55-62 2007

Adult pancreatic islets require differential pax6 gene dosage. Reviewed

Hamasaki A, Yamada Y, Kurose T, Ban N, Nagashima K, Takahashi A, Fujimoto S, Shimono D, Fujiwara M, Toyokuni S, Seino Y and Inagaki N.

Biochem. Biophys. Res. Commun. Vol. 353 page： 40-46 2007

Adenovirus-mediated gene delivery into mouse spermatogonial stem cells. Reviewed

Takehashi M, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ogura A, and Shinohara T.

Proc. Natl. Acad. Sci. USA Vol. 104 page： 2596-2601 2007

Pathological investigation of oxidative stress in the post-genomic era. Invited Reviewed

Toyokuni S and Akatsuka S.

Pathol. Int. Vol. 57 page： 461-473 2007

Overexpressin of a transcription factor LYL-1 induces T- and B-cell lymphoma in mice. Reviewed

Zhong Y, Li J, Hiai H, Toyokuni S* and Yamada Y* (*corresponding author).

Oncogene Vol. 26 page： 6937-6947 2007

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element. Reviewed

Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A and Nagata K.

Cell Struct. Funct. Vol. 32 page： 41-50 2007

Akt mediates self-renewal division of mouse spermatogonial stem cells. Reviewed

Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Kimura T, Nakano T, Ogura A and Shinohara T.

Development Vol. 134 page： 1853-1859 2007

Association of microRNA-34a overexpression with proliferation is cell type-dependent. Reviewed

Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J and Toyokuni S.

Cancer Sci. Vol. 98 page： 1845-1852 2007

FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts. Reviewed

Miyagawa-Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H, Okuno T, Toyokuni S, Tamaki K, Yamabe H, Manabe T and Uemoto S.

Am J. Pathol. Vol. 171 page： 1499-1508 2007

Production of knockout mice by gene targeting in multipotent germline stem cells. Reviewed

Takehashi M, Kanatsu-Shinohara M, Miki H, Lee J, Kazuki Y, Inoue K, Ogonuki N, Toyokuni S, Oshimura M, Ogura A and Shinohara T.

Dev. Biol. Vol. 312 page： 344-352 2007

Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model. Reviewed

Hakozaki T, Date A, Yoshii T, Toyokuni S, Yasui H and Sakurai H.

J. Dermatol. Res. Vol. 300 (Supplement 1) page： S51-56 2007

Analysis of genes associated with karyo-megalic cells in rat kidney after ferric nitilotriacetate treatment International journal

Lee, WH; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE Vol. 43 page： S24 - S24 2007

ARMET is a Soluble ER Protein Induced by the Unfolded Protein Response via ERSE-II Element

Mizobuchi Naomi, Hoseki Jun, Kubota Hiroshi, Toyokuni Shinya, Nozaki Jun-ichi, Naitoh Motoko, Koizumi Akio, Nagata Kazuhiro

Cell Structure and Function Vol. 32 ( 1 ) page： 41 - 50 2007

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Society for Cell Biology

Arginine rich, mutated in early stage of tumors (ARMET) was first identified as a human gene highly mutated in a variety of cancers. However, little is known about the characteristics of the ARMET protein and its expression. We identified ARMET as a gene upregulated by endoplasmic reticulum (ER) stress. Here, we show that the mouse homologue of ARMET is an 18-kDa soluble ER protein that is mature after cleavage of a signal sequence and has four intramolecular disulfide bonds, including two in CXXC sequences. ER stress stimulated ARMET expression, and the expression patterns of ARMET mRNA and protein in mouse tissues were similar to those of Grp78, an Hsp70-family protein required for quality control of proteins in the ER. A reporter gene assay using a mouse ARMET promoter revealed that the unfolded protein response of the ARMET gene is regulated by an ERSE-II element whose sequence is identical to that of the HERP gene. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the ER.<br>

DOI： 10.1247/csf.07001

Scopus

PubMed

CiNii Research

Chronic oxidative stress causes amplification and overexpresson of ptprzl protein tyrosine phosphatase to activate beta-catenin pathway

Liu, Y; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE Vol. 43 page： S154 - S155 2007

Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model. Reviewed

Hakozaki T, Date A, Yoshii T, Toyokuni S, Yasui H, Sakurai H

J. Dermatol. Res. Vol. 300 (Supplement 1) page： S51-56 2007

Oxidative stress is related to formation of Antoni B pattern and eosinophilic hyaline droplets in schwannoma. Reviewed

Yokoo H, Oishi T, Isoda, K, Nakazato Y, Toyokuni S

Neuropathology Vol. 27 page： 237-244 2007

ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element Reviewed

Naomi Mizobuchi, Jun Hoseki, Hiroshi Kubota, Shinya Toyokuni, Jun-ichi Nozaki, Motoko Naitoh, Akio Koizumi, Kazuhiro Nagata

CELL STRUCTURE AND FUNCTION Vol. 32 ( 1 ) page： 41 - 50 2007

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC CELL BIOLOGY

Arginine rich, mutated in early stage of tumors ( ARMET) was first identified as a human gene highly mutated in a variety of cancers. However, little is known about the characteristics of the ARMET protein and its expression. We identified ARMET as a gene upregulated by endoplasmic reticulum ( ER) stress. Here, we show that the mouse homologue of ARMET is an 18- kDa soluble ER protein that is mature after cleavage of a signal sequence and has four intramolecular disulfide bonds, including two in CXXC sequences. ER stress stimulated ARMET expression, and the expression patterns of ARMET mRNA and protein in mouse tissues were similar to those of Grp78, an Hsp70- family protein required for quality control of proteins in the ER. A reporter gene assay using a mouse ARMET promoter revealed that the unfolded protein response of the ARMET gene is regulated by an ERSE- II element whose sequence is identical to that of the HERP gene. ARMET is the second fully characterized ERSE- II- dependent gene and likely contributes to quality control of proteins in the ER.

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ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element

Mizobuchi Naomi, Hoseki Jun, Kubota Hiroshi, Toyokuni Shinya, Nozaki Jun-ichi, Naitoh Motoko, Koizumi Akio, Nagata Kazuhiro

CELL STRUCTURE AND FUNCTION Vol. 32 ( 1 ) page： 41 - 50 2007

Angiotensin II, oxidative stress, and extracellular matrix degradation during transition to LV failure in rats with hypertension. Reviewed

Takenaka H, Kihara Y, Iwanaga Y, Onozawa Y, Toyokuni S, Kita T

J. Mol. Cell. Cardiol. Vol. 41 page： 989-997 - 997 2007

Novel screening method for ultraviolet protection : Combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine

TOYOKUNI Shinya, YASUI Hiroyuki, DATE Akira, HAKOZAKI Tomohiro, AKATSUKA Shinya, KOHDA Haruyasu, YOSHII Takashi, SAKURAI Hiromu

Vol. 56 ( 12 ) page： 760 - 762 2006.12

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Papers - TOYOKUNI Shinya