Faculty Profiles - TOYOKUNI Shinya

Papers - TOYOKUNI Shinya

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An N-glycan structure correlates with pulmonary metastatic ability of cancer cells Reviewed International journal Open Access

K Sakuma, Fujimoto, I, S Hitoshi, F Tanaka, T Ikeda, K Tanabe, S Toyokuni, H Wada, T Mio, M Mishima, K Ikenaka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 340 ( 3 ) page： 829 - 835 2006.2

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

N-Glycan structures on the surface of cancer cells have diverse structures and play significant roles in metastatic process. However, little is known about their roles in organ-selective metastasis. Our study revealed that an alpha 1,6-fucosylated biantennary N-glycan structure designated A2G2F is characteristic of lungs, with far more abundant expression in normal human and murine lungs than in other organs. In this study, we further examined the role of A2G2F in pulmonary metastasis. We stained metastatic cancers by of alpha 1,6-fucose-specific Lens culinaris agglutinin lectin and revealed that pulmonary metastatic nodules more abundantly expressed alpha 1,6-fucosylated N-glycans than hepatic metastatic nodules from common primary cancers. The most specific alpha 1,6-fucosylated N-glycan structure in pulmonary metastatic cancer was identified to be A2G2F. Using a B16 melanoma cell metastasis model, we showed that A2G2F-rich B16 cells formed more Pulmonary metastatic nodules than A2G2F-poor cells. Our results suggest that A2G2F plays a critical role in Pulmonary metastasis. (c) 2005 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2005.12.072

Differences in oxidative stress dependence between gastric adenocarcinoma subtypes Reviewed

Brigitte Bancel, Jacques Esteve, Jean-Christophe Souquet, Shinya Toyokuni, Hiroshi Ohshima, Brigitte Pignatelli

WORLD JOURNAL OF GASTROENTEROLOGY Vol. 12 ( 7 ) page： 1005 - 1012 2006.2

Language：English Publishing type：Research paper (scientific journal) Publisher：W J G PRESS

AIM: To investigate the extent of oxidative stress in pre-neoplastic and neoplastic gastric mucosa in relation to their pathological criteria and histological subtypes.
METHODS: A total of 104 gastric adenocarcinomas from 98 patients (88 infiltrative and 16 intraepithelial tumors) were assessed immunohistochemically for expression of iNOS and occurrence of nitrotyrosine (NTYR)-containing proteins and 8-hydroxy-2'-deoxyguanosine (8-OH-dG)-containing DNA, as markers of NO production and damages to protein and DNA.
RESULTS: Tumor cells staining for NOS, NTYR and 8-OH-dG were detected in 41%, 62% and 50% of infiltrative carcinoma, respectively. The three markers were shown for the first time in intraepithelial carcinoma. The expression of iNOS was significantly more frequent in tubular carcinoma (TC) compared to diffuse carcinoma (DC) (54% vs 18%; P = 0.008) or in polymorphous carcinoma (PolyC) (54% vs 21%; P = 0.04). NTYR staining was obviously more often found in TC than that in PolyC (72% vs 30%; P = 0.03). There was a tendency towards a higher rate of iNOS staining when distant metastasis (pM) was present. In infiltrative TC, the presence of oxidative stress markers was not significantly correlated with histological grade, density of inflammation, the depth of infiltration (pT), lymph nodes dissemination (pN) and pathological stages (pTNM).
CONCLUSION: The iNOS-oxidative pathway may play an important role in TC, but moderately in PolyC and DC. DNA oxidation and protein nitration occur in the three subtypes. Based on the significant differences of NTYR levels, TC and PolyC appear as two distinct subtypes. (C) 2006 The WJG Press. All rights reserved.

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A novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine. Reviewed

Toyokuni S, Yasui H, Date A, Hakozaki T, Akatsuka S, Kohda H, Yoshii T and Sakurai H.

Pathol. Int. Vol. 56 page： 760-762 2006

Anchorage-independent growth of mouse male germline stem cells in vitro. Reviewed

Shinohara M, Inoue K, Lee J, Miki H, Ogonuki N, Toyokuni S, Ogura A and Shinohara T.

Biol. Reprod. Vol. 74 page： 522-529 2006

An N-glycan structure correlates with pulmonary metastatic ability of cancer cells. Reviewed

Sakuma K, Fujimoto I, Hitoshi S, Tanaka F, Ikeda T, Tanabe K, Toyokuni S, Wada H, Mio T, Mishima M, Ikenaka K.

Biochem. Biophys. Res. Commun. Vol. 349 page： 829-835 2006

Novel aspects of oxidative stress-associated carcinogenesis. Reviewed

Toyokuni S.

Antiox. Redox Signal. Vol. 8 page： 1373-1377 2006

Differences in oxidative stress dependence between gastric adenocarcinoma subtypes. Reviewed

Bancel B, Esteve J, Souquet JC, Toyokuni S, Ohshima H, Pignatelli B.

World J. Gastroenterol. Vol. 12 page： 1005-1012 2006

What has been learned from the studies of oxidative stress-induced carcinogenesis: proposal of the concept of oxygenomics. Reviewed

Toyokuni S, Akatsuka S.

J. Clin. Biochem. Nutr. Vol. 39 page： 3-10 2006

Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Reviewed

Kanatsu-Shinohara M, Ikawa M, Takehashi M, Ogonuki N, Miki H, Inoue K, Kazuki Y, Lee J, Toyokuni S, Oshimura M, Ogura A, Shinohara T.

Proc. Natl. Acad. Sci. USA Vol. 103 page： 8018-8023 2006

alfa-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage. Reviewed

Lee W-H, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu Y-T, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N and Toyokuni S.

Arch. Biochem. Biophys. Vol. 453 page： 168-178 2006

*Contrasting Genome-wide Distribution of 8-Hydroxyguanine and Acrolein-modified Adenine during Oxidative Stress-induced Renal Carcinogenesis. Reviewed

Akatsuka S, Aung TT, Dutta KK, Jiang L, Lee W-H, Liu Y-T, Onuki J, Shirase T, Yamasaki K, Ochi H, Naito Y, Yoshikawa T, Kasai H, Tominaga Y, Sakumi K, Nakabeppu Y, Kawai Y, Uchida K, Yamasaki A, Tsuruyama T, Yamada Y and Toyokuni S.

Am. J. Pathol. Vol. 169 page： 1328-1342 2006

Deletion and single nucleotide substitution at G:C are major mutations in the kidney of gpt delta transgenic mice after the Fenton reaction. Reviewed

Jiang L, Zhong Y, Akatsuka S, Liu Y-T, Dutta KK, Lee W-H, Onuki J, Masumura K, Nohmi T and Toyokuni S.

Cancer Sci. Vol. 97 page： 1159-1167 2006

Involvement of aminoacylase 1 in ferric nitrilotriacetate (Fe-NTA)-induced rat renal cell carcinoma

Onuki, J; Liu, Y; Lee, W; Jiang, L; Dutta, KK; Akatsuka, S; Toyokuni, S

FREE RADICAL RESEARCH Vol. 40 page： S128 - S128 2006

Iron-Induced Carcinogenesis Reviewed International journal

Toyokuni, S

OXIDATIVE STRESS, DISEASE AND CANCER page： 789 - 805 2006

Novel aspects of oxidative stress-associated carcinogenesis

Toyokuni Shinya

ANTIOXIDANTS & REDOX SIGNALING Vol. 8 ( 7-8 ) page： 1373 - 1377 2006

Oxidative stress and cancer International journal

Toyokuni Shinya

Annual Meeting of the Japanese Society of Toxicology Vol. 33 ( 0 ) page： 15 - 15 2006

Molecular characteristics of ferric nitrilotriacetate-induced deletions and base substitutions in the kidney of gpt delta transgenic mice

Jiang, L; Zhong, Y; Akatsuka, S; Onuki, J; Masumura, K; Nohmi, T; Toyokuni, S

FREE RADICAL RESEARCH Vol. 40 page： S128 - S128 2006

Iron-Induced Carcinogenesis

Toyokuni Shinya

OXIDATIVE STRESS, DISEASE AND CANCER page： 789 - 805 2006

Deletion and single nucleotide substitution at G:C are major mutations in the kidney of gpt delta transgenic mice after the Fenton reaction. Reviewed

Jiang L, Zhong Y, Akatsuka S, Liu Y-T, Dutta KK, Lee W-H, Onuki J, Masumura K, Nohmi T, Toyokuni S

Cancer Sci. Vol. 97 page： 1159-1167 2006

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

Akatsuka S., Aung T. T., Dutta K. K., Jiang L., Liu Y., Lee W., Onuki J., Shirase T., Naito Y., Yoshikawa T., Uchida K., Toyokuni S.

FREE RADICAL RESEARCH Vol. 40 page： S129 - S129 2006

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