研究者詳細 - 水野　正司

論文 - 水野　正司

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Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research 査読有り国際誌 Open Access

Ohno, T; Miyasaka, Y; Kuga, M; Ushida, K; Matsushima, M; Kawabe, T; Kikkawa, Y; Mizuno, M; Takahashi, M

EXPERIMENTAL ANIMALS 68 巻 ( 3 ) 頁： 243 - 255 2019年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本実験動物学会

Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral malaria and nephrotic syndrome, in addition to a rapid increase in parasitemia. Here, we focus on the analysis of host genetic factors that affect malarial pathogenesis and describe the characteristic features, utility, and future prospects for exploitation of the NC/Jic strain as a novel mouse model for malaria research.

DOI： 10.1538/expanim.18-0185

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients 査読有り国際誌

Tawada, M; Hamada, C; Suzuki, Y; Sakata, F; Sun, T; Kinashi, H; Katsuno, T; Takei, Y; Maruyama, S; Honda, K; Mizuno, M; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 5 ) 頁： 689 - 699 2019年5月

Differences in peritoneal solute transport rates in peritoneal dialysis 査読有り

Asano, M; Ishii, T; Hirayama, A; Mizuno, M; Suzuki, Y; Sakata, F; Akiyama, S; Maruyama, S; Soga, T; Kinashi, H; Katsuno, T; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 122 - 134 2019年1月

Safety and effectiveness of eculizumab for adult patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance 査読有り国際共著国際誌 Open Access

Kato, H; Miyakawa, Y; Hidaka, Y; Inoue, N; Ito, S; Kagami, S; Kaname, S; Matsumoto, M; Mizuno, M; Matsuda, T; Shimono, A; Maruyama, S; Fujimura, Y; Nangaku, M; Okada, H

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 65 - 75 2019年1月

HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy 査読有り国際誌 Open Access

Kawakita, C; Kinomura, M; Otaka, N; Kitagawa, M; Sugiyama, H; Kusano, N; Mizuno, M; Wada, J

INTERNAL MEDICINE 58 巻 ( 20 ) 頁： 3001 - 3007 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

DOI： 10.2169/internalmedicine.2439-18

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis 査読有り国際誌 Open Access

Katsuno, T; Ozaki, T; Ozeki, T; Hachiya, A; Kim, H; Kato, N; Ishimoto, T; Kato, S; Kosugi, T; Tsuboi, N; Mizuno, M; Ito, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 6 ) 頁： 1341 - 1350 2018年12月

Extracellular histones decrease the expression of membrane complement regulators 査読有り国際誌

Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

MOLECULAR IMMUNOLOGY 102 巻頁： 189-189 2018年10月

Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

Fukui, S; Suzuki, Y; Tawada, M; Matsukawa, Y; Imai, M; Maruyama, S; Ito, Y; Mizuno, M

MOLECULAR IMMUNOLOGY 102 巻頁： 152 - 152 2018年10月

Comprehensive analysis of complement proteins and genes in thrombotic microangiopathy in Japan

Hidaka, Y; Inoue, N; Ohtani, K; Ohtsuka, Y; Sawai, T; Miyata, T; Ohsawa, I; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY 102 巻頁： 163 - 163 2018年10月

SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

Hiramatsu, T; Mizuno, M; Nomori, S; Sakata, F; Suzuki, Y; Maruyama, S; Yasuhiko, I; Noguchi, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 33 巻頁： . 2018年5月

高齢腹膜透析患者の地域連携における現状と課題

伊藤恭彦, 水野正司, 鈴木康弘, 杉山斉, 深水圭, 猪阪善隆

医工学治療 30 巻 ( Suppl. ) 頁： 161 - 161 2018年3月

TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis 査読有り国際誌 Open Access

Kariya, T; Nishimura, H; Mizuno, M; Suzuki, Y; Matsukawa, Y; Sakata, F; Maruyama, S; Takei, Y; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 314 巻 ( 2 ) 頁： F167 - F180 2018年2月

Current Status of Peritoneal Dialysis in Japan 査読有り国際共著国際誌

Ito Yasuhiko, Tawada Mitsuhiro, Tine Sun, Mizuno Masashi, Suzuki Yasuhiro, Katsuno Takayuki

RECENT ADVANCES IN DIALYSIS THERAPY IN JAPAN 196 巻頁： 123 - 128 2018年

Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY 89 巻頁： 193-193 2017年9月

Establishment of a complement examination system for complement-related diseases by the Japanese Association for Complement Research (JACR) 国際誌

Hidaka, Y; Inoue, N; Ohtsuka, Y; Sawai, T; Miyata, T; Osawa, I; Ohtani, K; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY 89 巻頁： 192 - 192 2017年9月

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9 査読有り国際共著国際誌 Open Access

Taylor, RP; Lindorfer, MA; Cook, EM; Beurskens, FJ; Schuurman, J; Parren, PWHI; Zent, CS; VanDerMeid, KR; Burack, R; Mizuno, M; Morgan, BP

CLINICAL IMMUNOLOGY 181 巻頁： 24 - 28 2017年8月

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice 査読有り国際誌 Open Access

Tomita, T; Arai, S; Kitada, K; Mizuno, M; Suzuki, Y; Sakata, F; Nakano, D; Hiramoto, E; Takei, Y; Maruyama, S; Nishiyama, A; Matsuo, S; Miyazaki, T; Ito, Y

SCIENTIFIC REPORTS 7 巻 ( 1 ) 頁： 6450 2017年7月

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice 査読有り国際誌 Open Access

Sakata, F; Ito, Y; Mizuno, M; Sawai, A; Suzuki, Y; Tomita, T; Tawada, M; Tanaka, A; Hirayama, A; Sagara, A; Wada, T; Maruyama, S; Soga, T; Matsuo, S; Imai, E; Takei, Y

LABORATORY INVESTIGATION 97 巻 ( 4 ) 頁： 432 - 446 2017年4月

Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom 査読有り国際共著国際誌 Open Access

Okamoto, CK; Van den Berg, CW; Masashi, M; Gonçalves-de-Andrade, RM; Tambourgi, DV

TOXINS 9 巻 ( 3 ) 2017年3月

Complement component 5 promotes lethal thrombosis 国際誌 Open Access

Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

SCIENTIFIC REPORTS 7 巻頁： 42714 2017年2月

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