研究者詳細 - 水野　正司

論文 - 水野　正司

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水野正司

日本小児腎臓病学会雑誌 35 巻 ( 1 ) 頁： 5 - 12 2022年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本小児腎臓病学会

補体は，自然免疫（innate immunity）で重要な役割を担っている．特に21世紀に入り様々な役割が解明され，補体は免疫の中でも注目されるようになった．補体が，最近特に注目されている大きな理由として，C1インヒビターやC5中和抗体などの発見により，抗補体薬が実臨床で用いられるようになったことが挙げられる．このような背景の中，近年ますます補体から見た病態の解明が進んでいる．腎領域は，これまでも補体活性化による腎炎の発症進展，尿細管傷害進展への関与について様々な報告がある．近年，非典型溶血性尿毒症症候群やC3腎症といった病態に補体系の活性化や制御の異常の関与が明らかとなり，臨床医にとって補体が以前より身近な存在になってきた．ここでは，補体の関わる病態と補体関連の腎疾患の中でC3腎症に焦点を当てて，補体の面からその病態について最近の知見を交えながら概説する．

DOI： 10.3165/jjpn.rv.2022.0002

CiNii Research

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Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis 査読有り国際共著国際誌

Sugiyama, N; Tawada, M; Sun, T; Suzuki, Y; Kinashi, H; Yamaguchi, M; Katsuno, T; Aten, J; Vlahu, CA; van Kuppevelt, TH; Takei, Y; Ishimoto, T; Maruyama, S; Mizuno, M; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 25 巻 ( 9 ) 頁： 1035 - 1046 2021年9月

生体腎移植術を安全に施行できた著明な血小板減少症を合併するEpstein症候群の一例

安田宜成, 岡崎雅樹, 菱田学, 田中章仁, 斎藤尚二, 加藤規利, 鈴木康弘, 小杉智規, 水野正司, 藤田高史, 加藤真史, 藤元昭一, 此元隆雄, 丸山彰一

移植 56 巻 ( 総会臨時 ) 頁： P1 - 50 2021年9月

Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions 査読有り国際誌

Tawada, M; Ito, Y; Banshodani, M; Yamashita, M; Shintaku, S; Sun, T; Suzuki, Y; Kinashi, H; Kubo, Y; Ando, M; Yamaguchi, M; Katsuno, T; Mizuno, M; Kawanishi, H

NEPHROLOGY DIALYSIS TRANSPLANTATION 36 巻 ( 8 ) 頁： 1519 - 1526 2021年8月

A case of temporary metastatic pulmonary calcification in a patient with hyperparathyroidism on peritoneal dialysis 査読有り国際誌

Kawase, K; Takagi, K; Mizuno, M; Horie, M

CLINICAL NEPHROLOGY 95 巻 ( 3 ) 頁： 161 - 165 2021年3月

腎障害への補体の関与招待有り

金恒秀, 水野正司

腎臓内科 13 巻 ( 3 ) 頁： 361 - 367 2021年3月

Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis 査読有り国際誌 Open Access

Suzuki, Y; Mizuno, M; Kojima, H; Sato, Y; Kim, H; Kinashi, H; Katsuno, T; Ishimoto, T; Maruyama, S; Ito, Y

INTERNAL MEDICINE 60 巻 ( 3 ) 頁： 353 - 356 2021年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

Objective In patients on peritoneal dialysis (PD), it was reported that colonoscopy, but not upper gastrointestinal endoscopy, could cause peritonitis as a complication. A guideline of the International Society for Peritoneal Dialysis recommends preemptive intravenous antibiotics administration of ampicillin and aminoglycoside with or without metronidazole, to prevent colonoscopy-associated peritonitis. In this study, we retrospectively evaluated the effects of preemptive antibiotics therapy by oral administration instead of intravenous administration. Methods We investigated the incidence of colonoscopy-associated peritonitis in a single center. In 170 patients undergoing PD between January 2010 and December 2019, 50 colonoscopies were performed, including 49 with oral administration of amoxicillin and ciprofloxacin and/or metronidazole as preemptive therapy 1 hour before the colonoscopy procedure, and 1 without. Results We observed no incidence of colonoscopy-associated peritonitis. Conclusion Generally, oral administration of preemptive antibiotics is less painful and more convenient than intravenous administration, especially in outpatient procedures, such as a colonoscopy. Our results suggest that oral antibiotic administration might be effective for preventing colonoscopy-associated peritonitis in PD patients.

DOI： 10.2169/internalmedicine.5092-20

Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis 査読有り国際誌 Open Access

Ryuge, A; Kim, H; Suzuki, Y; Okazaki, M; Kojima, H; Saito, S; Kato, N; Ishimoto, T; Kosugi, T; Maruyama, S; Mizuno, M

INTERNAL MEDICINE 60 巻 ( 15 ) 頁： 2461 - 2464 2021年

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

Selenium is essential for human health; its deficiency leads to cardiac dysfunction. We herein report a 79-year-old man on peritoneal dialysis who presented with refractory hypotension caused by selenium deficiency. He was admitted to our hospital with bacterial pneumonia and hypotension and abnormal electrocardiogram (ECG) findings. Despite improvement of pneumonia, his hypotension continued, and intravenous noradrenalin could not be discontinued. His serum selenium level was extremely low, and he was started on intravenous selenium. His hypotension and ECG findings gradually improved, and noradrenalin was discontinued. Physicians should consider selenium deficiency when patients on peritoneal dialysis show refractory hypotension.

DOI： 10.2169/internalmedicine.6632-20

Impact on survival of urgent dialysis initiation in patients with end-stage renal disease: a case-control study 査読有り

Takagi, K; Mizuno, M; Kawase, K; Minoshima, K; Yamaha, M; Horie, M

CLINICAL AND EXPERIMENTAL NEPHROLOGY 24 巻 ( 12 ) 頁： 1154 - 1161 2020年12月

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2019年版査読有り

堀内孝彦, 大澤勲, 今井優樹, 大谷克城, 関根英治, 塚本浩, 中尾実樹, 西村純一, 水野正司, 村上良子, 山本哲郎, 木下タロウ, 大井洋之, 井上徳光, 若宮伸隆, 野々山恵章, 一般社団法人日本補体学会, 厚生労働省難治性疾患等政策研究事業「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」研究班

補体 57 巻 ( 1 ) 頁： 3 - 22 2020年12月

補体活性異常とC3腎症招待有り査読有り

水野正司

日本小児腎臓病学会雑誌 33 巻 ( 1Suppl. ) 頁： 51 - 51 2020年12月

ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

NEPHROLOGY 25 巻頁： 77 - 78 2020年10月

CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS

Mizuno, M; Suzuki, Y; Kojima, H; Sato, Y; Kinashi, H; Katsuno, T; Maruyama, S; Ito, Y

NEPHROLOGY 25 巻頁： 82 - 82 2020年10月

The effectiveness and safety of computed tomographic peritoneography and video-assisted thoracic surgery for hydrothorax in peritoneal dialysis patients: A retrospective cohort study in Japan 査読有り国際共著国際誌 Open Access

Matsuoka, N; Yamaguchi, M; Asai, A; Kamiya, K; Kinashi, H; Katsuno, T; Kobayashi, T; Tamai, H; Morinaga, T; Obayashi, T; Nakabayashi, K; Koide, S; Nakanishi, M; Koyama, K; Suzuki, Y; Ishimoto, T; Mizuno, M; Ito, Y

PLOS ONE 15 巻 ( 9 ) 頁： e0238602 2020年9月

補体からみたC3腎症とaHUS 招待有り

水野正司

日本小児腎臓病学会雑誌 33 巻 ( 1 ) 頁： 59 - 60 2020年4月

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia 査読有り国際誌 Open Access

Suzuki, Y; Mizuno, M; Sakata, F; Kojima, H; Sato, Y; Kishimoto, M; Suzuki, N; Kinashi, H; Saito, S; Katsuno, T; Kosugi, T; Maruyama, S; Murata, M; Kiyoi, H; Ito, Y

INTERNAL MEDICINE 59 巻 ( 5 ) 頁： 683 - 687 2020年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 45-year-old man with idiopathic aplastic anemia required renal replacement therapy (RRT) due to end-stage renal disease (ESRD). We succeeded in inserting the peritoneal dialysis (PD) catheter under cover of frequent red blood cell and platelet infusions because of severe pancytopenia. During the one-year period after starting PD using an ultraviolet-ray sterilization device, he developed severe leukopenia but no PD-related peritonitis or exit site/tunnel infection until he died of pneumonia. This case suggests that PD might be a suitable choice as RRT in ESRD patients with aplastic anemia, even in those with severe pancytopenia.

DOI： 10.2169/internalmedicine.3775-19

Dietary salt restriction during conservative therapy may prevent declines in residual renal function for the first year after starting peritoneal dialysis in patients with end-stage renal diseases 招待有り査読有り国際誌

Tetsuaki Hiramatsu, Masashi Mizuno, Yasuhiro Suzuki, Sumiyo Nomori, Yoshiko Shiga, Ting Sun, Takako Ishii, Hiroshi Kojima, Takayuki Katsuno, Tomohiro Nakamura, Tomoki Kosugi, Shoichi Maruyama, Tomio Koyama, Satoshi Noguchi, Yasuhiko Ito

Integrative Food, Nutrition and Metabolism 7 巻 ( 1 ) 2020年

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice 査読有り国際誌

Sun, T; Sakata, F; Ishii, T; Tawada, M; Suzuki, Y; Kinashi, H; Katsuno, T; Takei, Y; Maruyama, S; Mizuno, M; Ito, Y

NEPHROLOGY DIALYSIS TRANSPLANTATION 34 巻 ( 12 ) 頁： 2031 - 2042 2019年12月

CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY

Ozeki, T; Mizuno, M; Kobayashi, K; Iguchi, D; Sei, Y; Suzuki, Y; Kojima, H; Fukui, S; Yamashita, R; Kinashi, H; Imai, M; Maruyama, S; Ito, Y

MOLECULAR IMMUNOLOGY 114 巻頁： 422 - 422 2019年10月

C4著明低値を示した抗H因子抗体陽性C3腎炎の1例

田中寿弥, 木谷昂志, 塩津弥生, 砂原康人, 山内紘子, 中村格, 山下紀行, 草場哲郎, 益澤尚子, 小西英一, 澤井俊宏, 水野正司, 玉垣圭一

日本腎臓学会誌 61 巻 ( 6 ) 頁： 877 - 877 2019年8月

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