研究者詳細 - 水野　正司

論文 - 水野　正司

分割表示 343 件中 221 - 240 件目／全件表示 >>

Specific collaboration between rat membrane complement regulators, Crry and CD59, protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid

Mizuno, T; Mizuno, M; Morgan, BP; Okada, N; Noda, Y; Yuzawa, Y; Matsuo, S; Ito, Y

MOLECULAR IMMUNOLOGY 46 巻 ( 14 ) 頁： 2859 - 2860 2009年9月

Lymphatic vessels develop during tubulointerstitial fibrosis 査読有り国際誌

Sakamoto Izumi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sawai Akiho, Tanaka Akio, Maruyama Shoichi, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

KIDNEY INTERNATIONAL 75 巻 ( 8 ) 頁： 828 - 838 2009年4月

Lymphatic vessels develop during tubulointerstitial fibrosis. 査読有り

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney Int 75 巻頁： 828-838 2009年

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. 査読有り

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol 297 巻 ( F1510-1517 ) 2009年

The role of membrane complement regulators in the normal peritoneal cavity

Mizuno, T; Mizuno, M; Ito, Y; Matsuo, S; Noda, Y

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 巻頁： 59P - 59P 2009年

Zymosan, but not LPS, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model initiated by mechanical scraping 査読有り国際共著国際誌

Mizuno, M; Ito, Y; Mizuno, T; Harris, CL; Morgan, BP; Hepburn, N; Nishimura, H; Matsuo, S

MOLECULAR IMMUNOLOGY 45 巻 ( 16 ) 頁： 4153 - 4154 2008年10月

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model 査読有り国際誌

Nishimura Hayato, Ito Yasuhiko, Mizuno Masashi, Tanaka Akio, Morita Yoshiki, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 294 巻 ( 5 ) 頁： F1084 - F1093 2008年5月

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. 査読有り

Donev RM., Sivasankar B., Mizuno M., Morgan BP.

Mol. Immunol. 45 巻頁： 534-542 2008年1月

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. 査読有り国際共著国際誌

Donev RM, Sivasankar B, Mizuno M, Morgan BP

Molecular immunology 45 巻 ( 2 ) 頁： 534 - 542 2008年1月

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. 査読有り

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol 294 巻頁： F1084-F1093 2008年

本邦のCAPD療法の現況　–　CAPD療法に対する取り組み　大学・教育病院の役割招待有り

伊藤恭彦、水野正司、丸山彰一、湯澤　由紀夫、松尾清一

臨床透析 24 巻頁： 205-210 2008年

『特集　アシドーシスとアルカローシス』代謝性酸塩基平衡異常における治療の基本とその方法招待有り

伊藤恭彦、水野正司

薬局 59 巻頁： 42-47 2008年

Complement C3a receptor was highly found in the glomeruli of inflamed human lupus nephritis 国際共著国際誌

Mizuno, M; Blanchin, S; Gasque, P; Nishikawa, K; Matsuo, S

MOLECULAR IMMUNOLOGY 44 巻 ( 16 ) 頁： 3953 - 3953 2007年9月

CD59b is abundantly expressed only in testis and plays a role in acrosome activation and spermatozoal motility 査読有り国際共著国際誌

Donev, RM; Sivasankar, B; Mizuno, M; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 16 ) 頁： 3956 - 3956 2007年9月

A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a renal injury resembling haemolytic uremic syndrome. 査読有り

Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan BP., Matsuo S.

Am. J. Pathol. 171 巻頁： 402-414 2007年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Envenomation by the sea anemone Phyllodiscus semoni causes fulminant dermatitis and, rarely, acute renal failure in humans. Here, we investigated whether the venom extracted from the nematocysts (PsTX-T) was nephrotoxic when administered intravenously in rats and whether PsTX-T induced activation of the complement system. Although small dose of PsTX-T induced acute tubular necrosis in rats resembling pathology seen in patients, kidneys displayed glomerular injury with glomerular endothelial damage, thrombus formation, mesangiolysis, and partial rupture of glomerular basement membrane, accompanied by severe tubular necrosis at 24 hours after administration of 0.03 mg of PsTX-T per animal, similar to the glomerular findings typical of severe hemolytic uremic syndrome. The early stage injury was accompanied by specific PsTX-T binding, massive complement C3b, and membrane attack complex deposition in glomeruli in the regions of injury and decreased glomerular expression of complement regulators. A pathogenic role for complement was confirmed by demonstrating that systemic complement inhibition reduced renal injury. The isolated nephrotoxic component, a 115-kd protein toxin (PsTX-115), was shown to cause identical renal pathology. The demonstration that PsTX-T and PsTX-115 were highly nephrotoxic acting via induction of complement activation suggests that inhibition of complement might be used to prevent acute renal damage following envenomation by P. semoni.

CD55 in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa 国際共著国際誌

Mizuno, M; Donev, RM; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 7 ) 頁： 1613 - 1622 2007年3月

Immunisation with CD46 generates a strong autoantibody response targeting the spermatozoal acrosome in rat

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 1-3 ) 頁： 216 - 216 2007年1月

Immunization with autologous CD46 in rats generates a strong autoantibody response that targets spermatozoa. 査読有り

Mizuno M., Harris CL., Morgan BP.

J. Reprod. Immunol. 73 巻頁： 135-147 2007年

よく使う利尿薬について習熟する　スピロノラクトン招待有り

水野正司、伊藤恭彦

Medicina 44 巻頁： 359-342 2007年

High levels of complement C3a receptor in the glomeruli of inflamed human lupus nephritis. 査読有り

Mizuno M., Blanchin S., Gasque P., Nishikawa K., Matsuo S.

Am. J. Kidney Dis. 49 巻頁： 598-606 2007年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states. METHODS: Several antibodies were generated and used for immunohistochemistry and Western blot analyses to address C3aR expression and its regulation in vitro on cell lines of myeloid cells and nonmyeloid cell lineages. Furthermore, C3aR distribution was investigated in control nephrectomized kidneys and 116 biopsy specimens from patients with renal diseases, including lupus nephritis (lupus-N). RESULTS: C3aR is a highly N-glycosylated protein with an apparent molecular mass of 65 to 95 kd expressed by myeloid and endothelial cells. C3aR is particularly upregulated in response to interferon gamma treatment, but was unaffected by the other inflammatory cytokines, such as tumor necrosis factor alpha and transforming growth factor beta. In normal human kidney, C3aR staining was not observed. However, glomerular C3aR staining was detected in 42.9% of lupus-N specimens in association with immunoglobulin G immune-complex depositions. Staining intensity correlated with disease severity. C3aR was found in the endothelial area of 81.3% of samples classified as World Health Organization class IV with active lesions. Conversely, C3aR was not detected by means of immunohistochemistry in kidneys from patients with other renal diseases. CONCLUSION: Our data indicate that C3aR expression is tightly regulated and altered in certain disease conditions. C3aR may be used as a unique biomarker of diagnosis and disease activity in patients with lupus-N.

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