研究者詳細 - 水野　正司

CD59a is the primary regulator of membrane attack complex assembly in the mouse 査読有り国際共著国際誌

S Baalasubramanian, CL Harris, RM Donev, M Mizuno, N Omidvar, WC Song, BP Morgan

JOURNAL OF IMMUNOLOGY 173 巻 ( 6 ) 頁： 3684 - 3692 2004年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ASSOC IMMUNOLOGISTS

Gene-deleted mice have provided a potent tool in efforts to understand the roles of complement and complement-regulating proteins in vivo. In particular, mice deficient in the membrane regulators complement receptor 1-related gene/protein y, decay-accelerating factor, or CD59 have demonstrated homeostatic relevance and backcrossing between the strains has revealed cooperativity in regulation. In mouse, genes encoding decay-accelerating factor and CD59 have been duplicated and show differential expression in tissues, complicating interpretation and extrapolation of findings to man. The first described form of CD59, CD59a, is broadly distributed and deletion of the cd59a gene causes a mild hemolytic phenotype with increased susceptibility in complement-mediated disease models. The distribution of the second form, CD59b, was originally described as testis specific, but later by some as widespread. Deletion of the cd59b gene caused a severe hemolytic and thrombotic phenotype. To apply data from these mouse models to man it is essential to know the relative distribution and functional roles of these two forms of CD59. We have generated new specific reagents and used them in sensitive quantitative analyses to comprehensively characterize expression of mRNA and protein and functional roles of CD59a and CD59b in wild-type (wt) and CD59a-negative mice. cd59b mRNA was detected only in testis and, at very low levels, in bone marrow. CD59b protein was present on mature spermatozoa and precursors and, in trace amounts, erythrocytes. Erythrocyte CD59b did not inhibit complement lysis except when CD59a was absent or blocked. These data confirm that CD59a is the primary regulator of complement membrane attack in mouse.

学校検尿でみつかった、電顕像にて電子密度の異なる沈着物を認めるDense Deposit Diseaseの13歳女児例

The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. 招待有り査読有り国際共著国際誌

Mizuno M, Morgan BP

Current Drug Targets Inflammation & Allergy 3 巻頁： 85-94 2004年

Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. 査読有り国際共著国際誌

Fraser DA, Harris CL, Williams AS, Mizuno M, Gallagher S, Smith RA, Morgan BP

The Journal of biological chemistry 278 巻 ( 49 ) 頁： 48921 - 48927 2003年12月

Generation of a recombinant, membrane-targeted form of the complement regulator, CD59: activity in vitro and in vivo. 査読有り

Fraser DA., Harris CL., Williams AS., Mizuno M., Gallagher S., Smith RAG., Morgan BP.

J. Biol. Chem. 278 巻頁： 48921-48927 2003年

Membrane complement regulators protect against the development of type II collagen-induced arthritis in rats 査読有り国際共著国際誌

Mizuno, M; Nishikawa, K; Spiller, OB; Morgan, BP; Okada, N; Okada, H; Matsuo, S

ARTHRITIS AND RHEUMATISM 44 巻 ( 10 ) 頁： 2425 - 2434 2001年10月

CD59 protects rat kidney from complement mediated injury in collaboration with Crry 査読有り国際共著国際誌

Watanabe M, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Morgan BP, Okada N, Okada H, Matsuo S

KIDNEY INTERNATIONAL 58 巻 ( 4 ) 頁： 1569 - 1579 2000年10月

Acute renal failure after a sea anemone sting 査読有り国際誌

Mizuno, M; Nishikawa, K; Yuzawa, Y; Kanie, T; Mori, H; Araki, Y; Hotta, N; Matsuo, S

AMERICAN JOURNAL OF KIDNEY DISEASES 36 巻 ( 2 ) 頁： art. no. - E10 2000年8月

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced by anti-rat CD59 antibody. 査読有り国際共著

Mizuno M, Nishikawa K, Morgan B.P, Matsuo S

Clin. Exp. Immunol. 119 巻頁： 368-375 2000年

The effects of functional suppression of a membrane-bound complement regulatory protein, CD59, in the synovial tissue in rats 査読有り国際共著国際誌

Mizuno, M; Nishikawa, K; Goodfellow, RM; Piddlesden, SJ; Morgan, BP; Matsuo, S

ARTHRITIS AND RHEUMATISM 40 巻 ( 3 ) 頁： 527 - 533 1997年3月

Successfully treated C3 glomerulopathy in which protein and genetic analyses were useful for diagnosis. 査読有り国際誌

Kanzaki M, Kurahashi M, Watanabe K, Nishikawa M, Fukuoka K, Shimada N, Mizuno M, Asano K

CEN case reports 2024年9月

Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis. 査読有り国際誌

Ito Y, Sun T, Tawada M, Kinashi H, Yamaguchi M, Katsuno T, Kim H, Mizuno M, Ishimoto T

International journal of molecular sciences 25 巻 ( 16 ) 2024年8月

特集補体と腎疾患:温故知新腎疾患における補体と病態生理膜性増殖性糸球体腎炎/C3腎症招待有り

水野正司

腎と透析 97 巻 ( 1 ) 頁： 82 - 87 2024年7月

Effectiveness of additional topical antibiotics for recurrent or refractory exit-site infection: a case series 査読有り国際誌

Asai, N; Suzuki, Y; Asai, A; Kinashi, H; Kamiya, K; Hagita, J; Matsuoka, N; Kawamura, S; Fukui, S; Kim, H; Yamaguchi, M; Katsuno, T; Mizuno, M; Ishimoto, T; Ito, Y

RENAL REPLACEMENT THERAPY 10 巻 ( 1 ) 2024年6月

Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study 査読有り国際誌

Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 5 ) 頁： 431 - 439 2024年5月

Durvalumab plus carboplatin-etoposide treatment in a patient with small-cell lung cancer on hemodialysis: a case report and literature review. 査読有り国際誌

Ushijima F, Hase T, Yamashita Y, Kim H, Shimokata T, Kondo C, Sato T, Baba T, Watanabe S, Futamura K, Ando Y, Mizuno M, Ishii M

International cancer conference journal 13 巻 ( 2 ) 頁： 88 - 92 2024年4月

Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis 査読有り国際共著国際誌

Kamiya, K; Hatayama, N; Tawada, M; Asai, A; Yamauchi, M; Kinashi, H; Kunoki, S; Yamaguchi, M; Mizuno, M; Suzuki, Y; Banshodani, M; Ishimoto, T; Naito, M; Kawanishi, H; Ito, Y

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 7412 2024年3月

A Case of C3 Nephritis With a Rare Variant of the CFHR5 Gene 査読有り国際誌

Kamido, H; Yamamoto, S; Yokoi, H; Mizuno, M; Yanagita, M

CUREUS JOURNAL OF MEDICAL SCIENCE 16 巻 ( 2 ) 頁： e55102 2024年2月

今月の特集2 補体をめぐる話題注目の補体異常症 C3腎症

金恒秀, 水野正司

臨床検査 68 巻 ( 1 ) 頁： 88 - 92 2024年1月

特集補体revisited--抗補体療法はどこまで進んだか? 非典型溶血性尿毒症症候群招待有り

水野正司

医学のあゆみ 287 巻 ( 10 ) 頁： 757 - 761 2023年12月

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2023年版

堀内孝彦, 大澤勲, 宮田敏行, 赤津裕康, 今井優樹, 大谷克城, 奥健志, 関根英治, 塚本浩, 中尾実樹, 西村純一, 水野正司, 村上良子, 井上徳光, 一般社団法人日本補体学会HAEガイドライン作成委員会

補体 60 巻 ( 1 ) 頁： 23 - 23 2023年8月

手塚優子, 新野亮治, 木内拓海, 岡本健太郎, 村上至孝, 松田修, 澤井俊宏, 水野正司, 清水章

日本小児腎臓病学会雑誌 36 巻 ( Suppl. ) 頁： 179 - 179 2023年5月

Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model 査読有り国際誌

Kunoki Shunnosuke, Tatsukawa Hideki, Sakai Yukinao, Kinashi Hiroshi, Kariya Tetsuyoshi, Suzuki Yasuhiro, Mizuno Masashi, Yamaguchi Makoto, Sasakura Hiroyuki, Ikeno Masashi, Takeuchi Kosei, Ishimoto Takuji, Hitomi Kiyotaka, Ito Yasuhiko

LABORATORY INVESTIGATION 103 巻 ( 4 ) 頁： 100050 - 100050 2023年4月

Video-assisted thoracoscopic surgery for pleuroperitoneal communication 国際誌

Tsubouchi, H; Nakamura, S; Fukui, T; Kadomatsu, Y; Ueno, H; Ozeki, N; Fukumoto, K; Mizuno, M; Chen-Yoshikawa, TF

ASIAN JOURNAL OF ENDOSCOPIC SURGERY 16 巻 ( 2 ) 頁： 262 - 265 2023年4月

Nutritional Assessment and Nutrient Supplement in Patients with Chronic Kidney Disease

Mizuno, M

NUTRIENTS 15 巻 ( 8 ) 2023年4月

特集 Genetics in CKD 疾患編補体関連遺伝子の異常と腎疾患

金恒秀, 水野正司

腎と透析 94 巻 ( 3 ) 頁： 405 - 410 2023年3月

Case report: Thrombotic microangiopathy concomitant with macrophage activation syndrome in systemic lupus erythematosus refractory to conventional treatment successfully treated with eculizumab 査読有り国際誌

Yamaguchi, M; Mizuno, M; Kitamura, F; Iwagaitsu, S; Nobata, H; Kinashi, H; Banno, S; Asai, A; Ishimoto, T; Katsuno, T; Ito, Y

FRONTIERS IN MEDICINE 9 巻頁： 1097528 2023年1月

Recurrent Cerebrovascular Complications under Enzyme Replacement Therapy in a Patient with Fabry Disease on Peritoneal Dialysis 査読有り国際誌

Muto Reiko, Suzuki Yasuhiro, Shimizu Hideaki, Yasuda Kaoru, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

INTERNAL MEDICINE 62 巻 ( 3 ) 頁： 565 - 569 2023年

訪問看護ステーションアンケート調査からみたassisted PDの問題点と対策査読有り

高井奈美, 中林吉雄, 川島昭一, 水野正司, 小出滋久, 春日弘毅, 坂洋祐, 酒井英巳子, 稲熊大城, 伊藤恭彦

日本透析医学会雑誌 56 巻 ( 11 ) 頁： 401 - 409 2023年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

【目的】高齢腹膜透析（PD）患者を支えるためのassisted PD普及を妨げる要因を検討するため訪問看護ステーションのPD受け入れ状況の実態調査を実施．【方法】愛知県下の訪問看護ステーション368施設にアンケート調査を実施．【結果】回収数は132施設で，内訳はPD実施施設は37，PD検討中施設59，PD受け入れを検討しない施設20だった．PD患者の年間訪問割合は常に携わっている施設は20％だった．その他の施設はPD患者を看る機会が年に数例程度だった．訪問看護師による受け入れ条件は，「服薬管理」，「精神的サポート」が1番多く，次いで「バッグ交換」，「出口部ケア」だった．受け入れ見合わせ項目は，「Automated PD（APD）サイクラー準備」，「APD機器準備などの操作見守り」だった．【結論】assisted PDの要となる訪問看護師が不安なくPD患者を受け入れることができるためには，PD診療施設の医療スタッフとの共同訪問やケア方法の共有といった連携や多職種連携が求められる．

DOI： 10.4009/jsdt.56.401

Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells 査読有り国際誌

Kobayashi Kazuma, Ozeki Toshikazu, Kim Hangsoo, Imai Masaki, Kojima Hiroshi, Iguchi Daiki, Fukui Sosuke, Suzuki Masafumi, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

FRONTIERS IN MEDICINE 9 巻頁： 972592 2022年12月

Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice 査読有り国際誌

Tanaka Hiroya, Sun Ting, Kinashi Hiroshi, Kamiya Keisuke, Yamaguchi Makoto, Nobata Hironobu, Sakata Fumiko, Kim Hangsoo, Mizuno Masashi, Kunoki Shunnosuke, Sakai Yukinao, Hirayama Akiyoshi, Soga Tomoyoshi, Yoshikawa Kazuhiro, Ishimoto Takuji, Ito Yasuhiko

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 323 巻 ( 6 ) 頁： F654 - F665 2022年12月

A case of C3 glomerulopathy with nephritis-associated plasmin receptor positivity without a history of streptococcal infection 査読有り国際誌

Asano, M; Oda, T; Mizuno, M

CEN CASE REPORTS 11 巻 ( 2 ) 頁： 259 - 264 2022年5月

Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones 査読有り国際誌

Nagano, F; Mizuno, T; Imai, M; Takahashi, K; Tsuboi, N; Maruyama, S; Mizuno, M

FEBS OPEN BIO 12 巻 ( 1 ) 頁： 192 - 202 2022年1月

A novel model mouse for type 2 diabetes mellitus with early onset and persistent hyperglycemia 査読有り国際誌

Ohno, T; Miyasaka, Y; Yoshida, K; Kobayashi, M; Horio, F; Yokoi, N; Mizuno, M; Ikegami, H

EXPERIMENTAL ANIMALS 71 巻 ( 4 ) 頁： 510 - 518 2022年

補体活性の異常とC3腎症

水野正司

日本小児腎臓病学会雑誌 35 巻 ( 1 ) 頁： 5 - 12 2022年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本小児腎臓病学会

補体は，自然免疫（innate immunity）で重要な役割を担っている．特に21世紀に入り様々な役割が解明され，補体は免疫の中でも注目されるようになった．補体が，最近特に注目されている大きな理由として，C1インヒビターやC5中和抗体などの発見により，抗補体薬が実臨床で用いられるようになったことが挙げられる．このような背景の中，近年ますます補体から見た病態の解明が進んでいる．腎領域は，これまでも補体活性化による腎炎の発症進展，尿細管傷害進展への関与について様々な報告がある．近年，非典型溶血性尿毒症症候群やC3腎症といった病態に補体系の活性化や制御の異常の関与が明らかとなり，臨床医にとって補体が以前より身近な存在になってきた．ここでは，補体の関わる病態と補体関連の腎疾患の中でC3腎症に焦点を当てて，補体の面からその病態について最近の知見を交えながら概説する．

DOI： 10.3165/jjpn.rv.2022.0002

CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS

Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis 査読有り国際共著国際誌

Sugiyama, N; Tawada, M; Sun, T; Suzuki, Y; Kinashi, H; Yamaguchi, M; Katsuno, T; Aten, J; Vlahu, CA; van Kuppevelt, TH; Takei, Y; Ishimoto, T; Maruyama, S; Mizuno, M; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 25 巻 ( 9 ) 頁： 1035 - 1046 2021年9月

生体腎移植術を安全に施行できた著明な血小板減少症を合併するEpstein症候群の一例

安田宜成, 岡崎雅樹, 菱田学, 田中章仁, 斎藤尚二, 加藤規利, 鈴木康弘, 小杉智規, 水野正司, 藤田高史, 加藤真史, 藤元昭一, 此元隆雄, 丸山彰一

移植 56 巻 ( 総会臨時 ) 頁： P1 - 50 2021年9月

Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions 査読有り国際共著国際誌

Tawada, M; Ito, Y; Banshodani, M; Yamashita, M; Shintaku, S; Sun, T; Suzuki, Y; Kinashi, H; Kubo, Y; Ando, M; Yamaguchi, M; Katsuno, T; Mizuno, M; Kawanishi, H

NEPHROLOGY DIALYSIS TRANSPLANTATION 36 巻 ( 8 ) 頁： 1519 - 1526 2021年8月

A case of temporary metastatic pulmonary calcification in a patient with hyperparathyroidism on peritoneal dialysis 査読有り国際誌

Kawase, K; Takagi, K; Mizuno, M; Horie, M

CLINICAL NEPHROLOGY 95 巻 ( 3 ) 頁： 161 - 165 2021年3月

腎障害への補体の関与招待有り

金恒秀, 水野正司

腎臓内科 13 巻 ( 3 ) 頁： 361 - 367 2021年3月

Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis 査読有り国際誌

Suzuki, Y; Mizuno, M; Kojima, H; Sato, Y; Kim, H; Kinashi, H; Katsuno, T; Ishimoto, T; Maruyama, S; Ito, Y

INTERNAL MEDICINE 60 巻 ( 3 ) 頁： 353 - 356 2021年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

Objective In patients on peritoneal dialysis (PD), it was reported that colonoscopy, but not upper gastrointestinal endoscopy, could cause peritonitis as a complication. A guideline of the International Society for Peritoneal Dialysis recommends preemptive intravenous antibiotics administration of ampicillin and aminoglycoside with or without metronidazole, to prevent colonoscopy-associated peritonitis. In this study, we retrospectively evaluated the effects of preemptive antibiotics therapy by oral administration instead of intravenous administration. Methods We investigated the incidence of colonoscopy-associated peritonitis in a single center. In 170 patients undergoing PD between January 2010 and December 2019, 50 colonoscopies were performed, including 49 with oral administration of amoxicillin and ciprofloxacin and/or metronidazole as preemptive therapy 1 hour before the colonoscopy procedure, and 1 without. Results We observed no incidence of colonoscopy-associated peritonitis. Conclusion Generally, oral administration of preemptive antibiotics is less painful and more convenient than intravenous administration, especially in outpatient procedures, such as a colonoscopy. Our results suggest that oral antibiotic administration might be effective for preventing colonoscopy-associated peritonitis in PD patients.

DOI： 10.2169/internalmedicine.5092-20

Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis 査読有り国際誌

Ryuge, A; Kim, H; Suzuki, Y; Okazaki, M; Kojima, H; Saito, S; Kato, N; Ishimoto, T; Kosugi, T; Maruyama, S; Mizuno, M

INTERNAL MEDICINE 60 巻 ( 15 ) 頁： 2461 - 2464 2021年

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

Selenium is essential for human health; its deficiency leads to cardiac dysfunction. We herein report a 79-year-old man on peritoneal dialysis who presented with refractory hypotension caused by selenium deficiency. He was admitted to our hospital with bacterial pneumonia and hypotension and abnormal electrocardiogram (ECG) findings. Despite improvement of pneumonia, his hypotension continued, and intravenous noradrenalin could not be discontinued. His serum selenium level was extremely low, and he was started on intravenous selenium. His hypotension and ECG findings gradually improved, and noradrenalin was discontinued. Physicians should consider selenium deficiency when patients on peritoneal dialysis show refractory hypotension.

DOI： 10.2169/internalmedicine.6632-20

Impact on survival of urgent dialysis initiation in patients with end-stage renal disease: a case-control study 査読有り国際誌

Takagi, K; Mizuno, M; Kawase, K; Minoshima, K; Yamaha, M; Horie, M

CLINICAL AND EXPERIMENTAL NEPHROLOGY 24 巻 ( 12 ) 頁： 1154 - 1161 2020年12月

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2019年版査読有り

堀内孝彦, 大澤勲, 今井優樹, 大谷克城, 関根英治, 塚本浩, 中尾実樹, 西村純一, 水野正司, 村上良子, 山本哲郎, 木下タロウ, 大井洋之, 井上徳光, 若宮伸隆, 野々山恵章, 一般社団法人日本補体学会, 厚生労働省難治性疾患等政策研究事業「原発性免疫不全症候群の診断基準・重症度分類および診療ガイドラインの確立に関する研究」研究班

補体 57 巻 ( 1 ) 頁： 3 - 22 2020年12月

補体活性異常とC3腎症招待有り査読有り

水野正司

日本小児腎臓病学会雑誌 33 巻 ( 1Suppl. ) 頁： 51 - 51 2020年12月

ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

NEPHROLOGY 25 巻頁： 77 - 78 2020年10月

Mizuno, M; Suzuki, Y; Kojima, H; Sato, Y; Kinashi, H; Katsuno, T; Maruyama, S; Ito, Y

NEPHROLOGY 25 巻頁： 82 - 82 2020年10月

The effectiveness and safety of computed tomographic peritoneography and video-assisted thoracic surgery for hydrothorax in peritoneal dialysis patients: A retrospective cohort study in Japan 査読有り国際共著国際誌

Matsuoka, N; Yamaguchi, M; Asai, A; Kamiya, K; Kinashi, H; Katsuno, T; Kobayashi, T; Tamai, H; Morinaga, T; Obayashi, T; Nakabayashi, K; Koide, S; Nakanishi, M; Koyama, K; Suzuki, Y; Ishimoto, T; Mizuno, M; Ito, Y

PLOS ONE 15 巻 ( 9 ) 頁： e0238602 2020年9月

補体からみたC3腎症とaHUS 招待有り

水野正司

日本小児腎臓病学会雑誌 33 巻 ( 1 ) 頁： 59 - 60 2020年4月

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia 査読有り国際誌

Suzuki, Y; Mizuno, M; Sakata, F; Kojima, H; Sato, Y; Kishimoto, M; Suzuki, N; Kinashi, H; Saito, S; Katsuno, T; Kosugi, T; Maruyama, S; Murata, M; Kiyoi, H; Ito, Y

INTERNAL MEDICINE 59 巻 ( 5 ) 頁： 683 - 687 2020年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 45-year-old man with idiopathic aplastic anemia required renal replacement therapy (RRT) due to end-stage renal disease (ESRD). We succeeded in inserting the peritoneal dialysis (PD) catheter under cover of frequent red blood cell and platelet infusions because of severe pancytopenia. During the one-year period after starting PD using an ultraviolet-ray sterilization device, he developed severe leukopenia but no PD-related peritonitis or exit site/tunnel infection until he died of pneumonia. This case suggests that PD might be a suitable choice as RRT in ESRD patients with aplastic anemia, even in those with severe pancytopenia.

DOI： 10.2169/internalmedicine.3775-19

Dietary salt restriction during conservative therapy may prevent declines in residual renal function for the first year after starting peritoneal dialysis in patients with end-stage renal diseases 招待有り査読有り国際誌

Tetsuaki Hiramatsu, Masashi Mizuno, Yasuhiro Suzuki, Sumiyo Nomori, Yoshiko Shiga, Ting Sun, Takako Ishii, Hiroshi Kojima, Takayuki Katsuno, Tomohiro Nakamura, Tomoki Kosugi, Shoichi Maruyama, Tomio Koyama, Satoshi Noguchi, Yasuhiko Ito

Integrative Food, Nutrition and Metabolism 7 巻 ( 1 ) 2020年

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice 査読有り国際誌

Sun, T; Sakata, F; Ishii, T; Tawada, M; Suzuki, Y; Kinashi, H; Katsuno, T; Takei, Y; Maruyama, S; Mizuno, M; Ito, Y

NEPHROLOGY DIALYSIS TRANSPLANTATION 34 巻 ( 12 ) 頁： 2031 - 2042 2019年12月

CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY

Ozeki, T; Mizuno, M; Kobayashi, K; Iguchi, D; Sei, Y; Suzuki, Y; Kojima, H; Fukui, S; Yamashita, R; Kinashi, H; Imai, M; Maruyama, S; Ito, Y

MOLECULAR IMMUNOLOGY 114 巻頁： 422 - 422 2019年10月

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis 査読有り国際共著国際誌

Kinashi, H; Toda, N; Sun, T; Nguyen, TQ; Suzuki, Y; Katsuno, T; Yokoi, H; Aten, J; Mizuno, M; Maruyama, S; Yanagita, M; Goldschmeding, R; Ito, Y

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 12175 - 12175 2019年8月

C4著明低値を示した抗H因子抗体陽性C3腎炎の1例

田中寿弥, 木谷昂志, 塩津弥生, 砂原康人, 山内紘子, 中村格, 山下紀行, 草場哲郎, 益澤尚子, 小西英一, 澤井俊宏, 水野正司, 玉垣圭一

日本腎臓学会誌 61 巻 ( 6 ) 頁： 877 - 877 2019年8月

Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research 国際誌

Ohno, T; Miyasaka, Y; Kuga, M; Ushida, K; Matsushima, M; Kawabe, T; Kikkawa, Y; Mizuno, M; Takahashi, M

EXPERIMENTAL ANIMALS 68 巻 ( 3 ) 頁： 243 - 255 2019年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本実験動物学会

Malaria is caused by Plasmodium parasites and is one of the most life-threatening infectious diseases in humans. Infection can result in severe complications such as cerebral malaria, acute lung injury/acute respiratory distress syndrome, and acute renal injury. These complications are mainly caused by P. falciparum infection and are major causes of death associated with malaria. There are a few species of rodent-infective malaria parasites, and mice infected with such parasites are now widely used for screening candidate drugs and vaccines and for studying host immune responses and pathogenesis associated with disease-related complications. We found that mice of the NC/Jic strain infected with rodent malarial parasites exhibit distinctive disease-related complications such as cerebral malaria and nephrotic syndrome, in addition to a rapid increase in parasitemia. Here, we focus on the analysis of host genetic factors that affect malarial pathogenesis and describe the characteristic features, utility, and future prospects for exploitation of the NC/Jic strain as a novel mouse model for malaria research.

DOI： 10.1538/expanim.18-0185

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients 査読有り国際誌

Tawada, M; Hamada, C; Suzuki, Y; Sakata, F; Sun, T; Kinashi, H; Katsuno, T; Takei, Y; Maruyama, S; Honda, K; Mizuno, M; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 5 ) 頁： 689 - 699 2019年5月

Differences in peritoneal solute transport rates in peritoneal dialysis 査読有り

Asano, M; Ishii, T; Hirayama, A; Mizuno, M; Suzuki, Y; Sakata, F; Akiyama, S; Maruyama, S; Soga, T; Kinashi, H; Katsuno, T; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 122 - 134 2019年1月

HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy 査読有り国際誌

Kawakita, C; Kinomura, M; Otaka, N; Kitagawa, M; Sugiyama, H; Kusano, N; Mizuno, M; Wada, J

INTERNAL MEDICINE 58 巻 ( 20 ) 頁： 3001 - 3007 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.

DOI： 10.2169/internalmedicine.2439-18

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis 査読有り国際誌

Katsuno, T; Ozaki, T; Ozeki, T; Hachiya, A; Kim, H; Kato, N; Ishimoto, T; Kato, S; Kosugi, T; Tsuboi, N; Mizuno, M; Ito, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 6 ) 頁： 1341 - 1350 2018年12月

Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rats pretreated with methylglyoxal 査読有り国際誌

Iguchi, D; Mizuno, M; Suzuki, Y; Sakata, F; Maruyama, S; Okada, A; Okada, H; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 315 巻 ( 6 ) 頁： F1732 - F1746 2018年12月

Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

Fukui, S; Suzuki, Y; Tawada, M; Matsukawa, Y; Imai, M; Maruyama, S; Ito, Y; Mizuno, M

MOLECULAR IMMUNOLOGY 102 巻頁： 152 - 152 2018年10月

Extracellular histones decrease the expression of membrane complement regulators 査読有り国際誌

Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

MOLECULAR IMMUNOLOGY 102 巻頁： 189-189 2018年10月

Comprehensive analysis of complement proteins and genes in thrombotic microangiopathy in Japan

Hidaka, Y; Inoue, N; Ohtani, K; Ohtsuka, Y; Sawai, T; Miyata, T; Ohsawa, I; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY 102 巻頁： 163 - 163 2018年10月

SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

Hiramatsu, T; Mizuno, M; Nomori, S; Sakata, F; Suzuki, Y; Maruyama, S; Yasuhiko, I; Noguchi, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 33 巻頁： . 2018年5月

高齢腹膜透析患者の地域連携における現状と課題

伊藤恭彦, 水野正司, 鈴木康弘, 杉山斉, 深水圭, 猪阪善隆

医工学治療 30 巻 ( Suppl. ) 頁： 161 - 161 2018年3月

TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis 査読有り国際誌

Kariya, T; Nishimura, H; Mizuno, M; Suzuki, Y; Matsukawa, Y; Sakata, F; Maruyama, S; Takei, Y; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 314 巻 ( 2 ) 頁： F167 - F180 2018年2月

Current Status of Peritoneal Dialysis in Japan 査読有り国際共著国際誌

Ito Yasuhiko, Tawada Mitsuhiro, Tine Sun, Mizuno Masashi, Suzuki Yasuhiro, Katsuno Takayuki

RECENT ADVANCES IN DIALYSIS THERAPY IN JAPAN 196 巻頁： 123 - 128 2018年

Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

MOLECULAR IMMUNOLOGY 89 巻頁： 193-193 2017年9月

Establishment of a complement examination system for complement-related diseases by the Japanese Association for Complement Research (JACR)

Hidaka, Y; Inoue, N; Ohtsuka, Y; Sawai, T; Miyata, T; Osawa, I; Ohtani, K; Okada, H; Kinoshita, T; Sekine, H; Tsukamoto, H; Nakao, M; Mizuno, M; Murakami, Y; Horiuchi, T; Wakamiya, N

MOLECULAR IMMUNOLOGY 89 巻頁： 192 - 192 2017年9月

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9 査読有り国際共著国際誌

Taylor, RP; Lindorfer, MA; Cook, EM; Beurskens, FJ; Schuurman, J; Parren, PWHI; Zent, CS; VanDerMeid, KR; Burack, R; Mizuno, M; Morgan, BP

CLINICAL IMMUNOLOGY 181 巻頁： 24 - 28 2017年8月

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice 査読有り国際誌

Tomita, T; Arai, S; Kitada, K; Mizuno, M; Suzuki, Y; Sakata, F; Nakano, D; Hiramoto, E; Takei, Y; Maruyama, S; Nishiyama, A; Matsuo, S; Miyazaki, T; Ito, Y

SCIENTIFIC REPORTS 7 巻 ( 1 ) 頁： 6450 2017年7月

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice 査読有り国際共著国際誌

Sakata, F; Ito, Y; Mizuno, M; Sawai, A; Suzuki, Y; Tomita, T; Tawada, M; Tanaka, A; Hirayama, A; Sagara, A; Wada, T; Maruyama, S; Soga, T; Matsuo, S; Imai, E; Takei, Y

LABORATORY INVESTIGATION 97 巻 ( 4 ) 頁： 432 - 446 2017年4月

Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom 査読有り国際共著国際誌

Okamoto, CK; Van den Berg, CW; Masashi, M; Gonçalves-de-Andrade, RM; Tambourgi, DV

TOXINS 9 巻 ( 3 ) 2017年3月

Complement component 5 promotes lethal thrombosis 国際誌

Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

SCIENTIFIC REPORTS 7 巻頁： 42714 2017年2月

PDのエビデンス

多和田光洋, 鈴木康弘, 水野正司, 伊藤恭彦

日本透析医学会雑誌 50 巻 ( 11 ) 頁： 685 - 691 2017年

Therapeutic effects of a C5a antagonist, AcPepA, for severe peritoneal injuries associated with fungal infection in a rat model

Mizuno, M; Iguchi, D; Shigemoto, E; Kobayashi, K; Sakata, F; Suzuki, Y; Okada, A; Okada, H; Matsuo, S; Ito, Y

IMMUNOBIOLOGY 221 巻 ( 10 ) 頁： 1212 - 1212 2016年10月

C5 promotes histone-induced lethal thromboembolism 査読有り

Mizuno, T; Yoshioka, K; Mizuno, M; Tsuboi, N; Maruyama, S; Nagamatsu, T; Imai, M

IMMUNOBIOLOGY 221 巻 ( 10 ) 頁： 1140 - 1141 2016年10月

Complement promote releasing transglutaminase 2 from cytoplasm 査読有り国際誌

Hara, K; Mizuno, T; Takahashi, K; Mizuno, M; Kato, A; Onouchi, T; Tsutsumi, Y; Tatsukawa, H; Nagamatsu, T; Hitomi, K; Yuzawa, Y

IMMUNOBIOLOGY 221 巻 ( 10 ) 頁： 1142 - 1142 2016年10月

TGF-β-VEGF-A PATHWAY INDUCES NEOANGIOGENESIS IN PERITONEAL FIBROSIS OF PERITONEAL DIALYSIS

Kariya, T; Ito, Y; Mizuno, M; Suzuki, Y; Sakata, F; Terabayashi, T; Ishii, T; Tawada, M; Iguchi, D; Maruyama, S; Matsuo, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 31 巻頁： 35 - 35 2016年5月

APOPTOSIS INHIBITOR OF MACROPHAGE PROTEIN AMELIORATES FUNGUS-INDUCED PERITONEAL INJURY IN MICE BY UPREGULATION OF CLEARANCE OF NECROTIC DEBRIS

Tomita, T; Ito, Y; Kitada, K; Mizuno, M; Suzuki, Y; Sakata, F; Nakano, D; Maruyama, S; Arai, S; Miyazaki, T; Nishiyama, A; Matsuo, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 31 巻頁： 1503 - 1503 2016年5月

Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients 査読有り国際誌

Tawada, M; Ito, Y; Hamada, C; Honda, K; Mizuno, M; Suzuki, Y; Sakata, F; Terabayashi, T; Matsukawa, Y; Maruyama, S; Imai, E; Matsuo, S; Takei, Y

PLOS ONE 11 巻 ( 4 ) 頁： e0154644 2016年4月

Depression of complement regulatory factors in rat and human renal grafts is associated with the pregress of acute T-cell medicated rejection. 査読有り

Yamanaka K., Kakuta Y., Miyagawa S., Nakazawa S., Kato T., Abe T., Imamura R., Okumi M., Maeda A., Mizuno M., Nonomura N.

PlosOne 11 巻 ( 2 ) 頁： e0148881 2016年

Rat Models of Acute and/or Chronic Peritoneal Injuries Including Peritoneal Fibrosis and Peritoneal Dialysis Complications

Mizuno Masashi, Ito Yasuhiko

KIDNEY RESEARCH: EXPERIMENTAL PROTOCOLS, 2ND EDITION 1397 巻頁： 35 - 43 2016年

Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse 査読有り国際誌

Yamaguchi, M; Ando, M; Kato, S; Katsuno, T; Kato, N; Kosugi, T; Sato, W; Tsuboi, N; Yasuda, Y; Mizuno, M; Ito, Y; Matsuo, S; Maruyama, S

JOURNAL OF RHEUMATOLOGY 42 巻 ( 10 ) 頁： 1853 - 1860 2015年10月

Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury 査読有り国際誌

Terabayashi Takeshi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Kinashi Hiroshi, Sakata Fumiko, Tomita Takako, Iguchi Daiki, Tawada Mitsuhiro, Nishio Ryosuke, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi, Takei Yoshifumi

LABORATORY INVESTIGATION 95 巻 ( 9 ) 頁： 1029 - 1043 2015年9月

Development of encapsular peritoneal sclerosis (EPS)-like peritonitis in rat and complement activation 国際誌

Iguchi, D; Mizuno, M; Shigemoto, E; Sakata, F; Suzuki, Y; Okada, A; Okada, H; Maruyama, S; Matsuo, S; Ito, Y

MOLECULAR IMMUNOLOGY 67 巻 ( 1 ) 頁： 145 - 146 2015年9月

Calcified Amorphous Tumor in the Left Atrium in a Patient on Long-term Peritoneal Dialysis 査読有り国際誌

Tanaka, A; Mizuno, M; Suzuki, Y; Oshima, H; Sakata, F; Ishikawa, H; Tsukushi, S; Ito, Y

INTERNAL MEDICINE 54 巻 ( 5 ) 頁： 481 - 485 2015年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 66-year-old woman with an 11-year history of peritoneal dialysis (PD) for diabetic nephropathy and renal failure exhibited a movable tumor in the left atrium on echocardiography. Tumor resection was performed due to the difficulty in diagnosing the tumor and the future risk of heart failure and embolization. Light microscopy showed a calcified amorphous tumor (CAT), a rare intracardiac mass characterized by the presence of a pedicle and diffuse calcification. An increased calcium-phosphate product level was suspected as an etiology, although degeneration, inflammation and/or mineral balance disorders may also induce the development of CAT. We herein report the first known case of CAT in a PD patient.

DOI： 10.2169/internalmedicine.54.2967

The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. 査読有り

Tanaka A., Katsuno T., Ozaki T., Sakata F., Kato N., Suzuki Y., Kosugi T., Kato S., Tsuboi N., Sato W., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

70 巻頁： 217-223 2015年

Smoking is a risk factor for the relapse of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Yamaguchi M., Ando M., Kato S., Katsuno T., Kato N., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S

J Rheumatology 頁： in press 2015年

Vasuclar endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury.

Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Lab Invest 頁： in press 2015年

Successful Treatment of Cryptococcus laurentii Peritonitis in a Patient on Peritoneal Dialysis 国際誌

Asano, M; Mizutani, M; Nagahara, Y; Inagaki, K; Kariya, T; Masamoto, D; Urai, M; Kaneko, Y; Ohno, H; Miyazaki, Y; Mizuno, M; Ito, Y

INTERNAL MEDICINE 54 巻 ( 8 ) 頁： 941 - 944 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 32-year-old man on peritoneal dialysis (PD) was hospitalized for seven days due to fever. A diagnosis of yeast-like fungal peritonitis was made by Gram staining. The patient was started on intravenous micafungin and oral fluconazole therapy following removal of the PD catheter. A fungal pathogen was isolated from the peritoneal fluid and identified as Cryptococcus species. Based on antifungal susceptibility testing, the treatment was changed to voriconazole and continued for 3 months. A genetic analysis identified the isolate as Cryptococcus laurentii (C. laurentii). This patient was diagnosed with C. laurentii PD-related peritonitis and was successfully treated with voriconazole and removal of the PD catheter.

DOI： 10.2169/internalmedicine.54.3586

透析導入時の薬剤選択に苦慮した急性間欠性ポルフィリン症の1例

小島圭太郎, 水野正司, 服部愼一, 蓑島謙一, 山羽正義, 堀江正宣

日本透析医学会雑誌 48 巻 ( 7 ) 頁： 437 - 441 2015年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

症例は45歳, 女性. 1987年に急性間欠性ポルフィリン症と診断された. 慢性腎不全のため2008年12月当院へ紹介. 翌年4月慢性腎不全が増悪し, 透析導入準備のため入院となった. ポルフィリン症は, 禁忌薬剤の使用により代謝障害を誘導し発症および増悪する. このため, 透析導入時には薬剤選択に注意する必要がある. 2009年6月透析導入基準を満たしたため, 薬剤の安全性を十分配慮した上で, アムロジピンおよびエポエチンベータの使用を開始し血液透析を導入した. その後, 上記薬剤使用下で維持血液透析を施行しているが特別な異常を認めていない. 新しく使用が可能であった薬剤について報告した.

DOI： 10.4009/jsdt.48.437

腹膜透析排液中の補体活性化産物測定により、腹膜炎の予後を予想できるか?

Patient Age and the Prognosis of Idiopathic Membranous Nephropathy 査読有り国際誌

Yamaguchi Makoto, Ando Masahiko, Yamamoto Ryohei, Akiyama Shinichi, Kato Sawako, Katsuno Takayuki, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

PLOS ONE 9 巻 ( 10 ) 頁： e110376 2014年10月

Level of soluble C5b-9 complex in dialysis fluid may be a predictor of poor prognosis in peritonitis in peritoneal dialysis patients, especially in culture negative peritonitis 国際共著国際誌

Mizuno, M; Ito, Y; Higashide, K; Sei, Y; Iguchi, D; Sakata, F; Suzuki, Y; Ito, I; Horie, M; Morgan, BP; Matsuo, S

MOLECULAR IMMUNOLOGY 61 巻 ( 2 ) 頁： 225 - 225 2014年10月

水野正司, 伊藤恭彦, 東出慶子, 清祐実, 井口大旗, 坂田史子, 鈴木康弘, 堀江正宣, Morgan B. Paul, 松尾清一

補体 51 巻 ( 1 ) 頁： 93 - 94 2014年8月

Smoking Is a Risk Factor for the Progression of Idiopathic Membranous Nephropathy 査読有り国際誌

Yamaguchi, M; Ando, M; Yamamoto, R; Akiyama, S; Kato, S; Katsuno, T; Kosugi, T; Sato, W; Tsuboi, N; Yasuda, Y; Mizuno, M; Ito, Y; Matsuo, S; Maruyama, S

PLOS ONE 9 巻 ( 6 ) 頁： e100835 2014年6月

ASSOCIATION OF ANKLE BRACHIAL INDEX AND PROTEIN-ENERGY WASTING WITH MORTALITY IN PATIENTS ON HEMODIALYSIS 国際誌

Keiko, K; Hirotake, K; Ryo, T; Chieko, M; Kiyohito, K; Hirohisa, K; Masashi, M; Yasuhiro, S; Shouichi, M; Yasuhiko, I; Seiichi, M

NEPHROLOGY 19 巻頁： 178 - 179 2014年5月

LYMPHANGIOGENESIS DEVELOPS DURING PERITONEAL FIBROSIS IN RAT PERITONITIS MODELS

Takeshi, T; Yasuhiko, I; Hiroshi, K; Masashi, M; Yasuhiro, S; Fumiko, S; Takako, T; Mitsuhiro, T; Yumi, S; Daiki, I; Seiichi, M

NEPHROLOGY 19 巻頁： 193 - 193 2014年5月

IMPROVEMENT OF PREVALENCE OF PERITONEAL DIALYSIS (PD) THERAPY IN END-STAGE RENAL DISEASE (ESRD) PATIENTS FROM 2010 TO 2012 IN THE TOKAI AREA OF JAPAN. - FIVE YEARS AFTER THE PREVIOUS STUDY

Masashi, M; Yasuhiko, I; Yasuhiro, S; Yosuke, S; Takeyuki, H; Hirofumi, T; Makoto, M; Tomohiko, N; Norimi, O; Hirotake, K; Hideaki, S; Hisashi, K; Kei, K; Satoshi, S; Shoichi, M; Seiichi, M

NEPHROLOGY 19 巻頁： 113 - 113 2014年5月

EXPRESSION OF MEMBRANE COMPLEMENT REGULATORS IN MESOTHERIAL CELLS OF PATIENTS' PERITONEUM ON PERITONEAL DIALYSIS THERAPY

Yumi, S; Masashi, M; Yasuhiro, S; Masaski, I; Keiko, H; Fumiko, S; Daiki, I; Noriko, O; Seiichi, M; Yasuhiko, I

NEPHROLOGY 19 巻頁： 151 - 151 2014年5月

Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation 査読有り国際誌

Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Sato Waichi, Suzuki Yasuhiro, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi

CYTOTHERAPY 16 巻 ( 3 ) 頁： 357 - 368 2014年3月

Long-term effects of spironolactone in peritoneal dialysis patients. 査読有り

Ito Y., Mizuno M., Suzuki Y., Tamai G., Hiramatsu T.,Ohashi H., Ito I., Kasuga H., Horie M., Maruyama S., Yuzawa Y., Matsubara T., Matsuo S, Nagoya Spiro Study Group.

J Am Soc Nephrol 頁： in press 2014年

Smoking is a risk factor for the progression of idiopathic membranous nephropathy. 査読有り

Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

PloS One ９巻 ( ６ ) 頁： e100835 2014年

Patient age and the prognosis of idiopathic membrane nephropathy. 査読有り

Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

ProsOne 9 巻 ( 10 ) 頁： e110376 2014年

Future Expectations of Diagnostic Approaches for Treating Endogenous Peritonitis in Patients on Peritoneal Dialysis Reply 国際誌

Mizuno, M; Suzuki, Y; Ito, Y

INTERNAL MEDICINE 53 巻 ( 6 ) 頁： 647 - 647 2014年

Expression of membrane complement regulators in patients on peritoneal dialysis therapy 国際共著国際誌

Sei, Y; Mizuno, M; Imai, M; Suzuki, Y; Higashide, K; Okada, N; Harris, C; Matsuo, S; Ito, Y

MOLECULAR IMMUNOLOGY 56 巻 ( 3 ) 頁： 277 - 278 2013年12月

Anti-C5a complementary peptide ameliorates acute peritoneal injury induced by neutralization of Crry and CD59 査読有り国際誌

Mizuno, T; Mizuno, M; Imai, M; Suzuki, Y; Kushida, M; Noda, Y; Maruyama, S; Okada, H; Okada, N; Matsuo, S; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305 巻 ( 11 ) 頁： F1603 - F1616 2013年12月

TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis.

Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y

Journal of the American Society of Nephrology : JASN 24 巻 ( 10 ) 頁： 1627 - 42 2013年10月

Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. 査読有り

Katsuno T., Osaki T., Saka Y., Furuhashi K., Kim H., Yasuda K., Yamamoto T., Sato W., Tsuboi N., Mizuno M., Ito Y., Imai E., Matsuo S., Maruyama S.

Cell Transplant 22 巻 ( 2 ) 頁： 287-297 2013年

TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis. 査読有り

Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Journal of American Society of Nephrology 24 巻 ( 10 ) 頁： 1627-1642 2013年

Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. 査読有り

Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.

Internal Medicine 52 巻 ( 11 ) 頁： 1177-1181 2013年

Clostridium perfringensによるCAPD関連腹膜炎と悪性中皮腫の関連が示唆された1剖検例査読有り

浅野麻里奈, 稲垣浩司, 狩谷哲芳, 浅野周一, 政本大二郎, 水谷真, 高橋洋平, 水野正司, 伊藤恭彦

日本透析医学会雑誌 46 巻 ( 9 ) 頁： 949 - 954 2013年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

症例は74歳，男性．腎硬化症による慢性腎不全にて2007年に腹膜透析（CAPD）導入．2010年6月，7月，11月にCAPD関連腹膜炎のため入院，抗菌治療で改善した．2011年1月に再度CAPD関連腹膜炎のため入院．CTにて，脾上極の腫瘤と腹腔内に多発する結節を認めた．悪性腫瘍が疑われたが，全身状態不良のため精査は行わず，腹膜炎改善後は経過観察となった．2011年3月某日，再度CAPD腹膜炎のため入院したが，急激に循環動態が悪化し，同日永眠された．後日，排液からClostridium perfringensとStreptococcus mitisが培養され，また，病理解剖の結果，腹腔内多発結節は悪性中皮腫の腹膜播種と判明した．CAPD関連腹膜炎が死因となったが，悪性中皮腫とCAPD関連腹膜炎との関連が疑われた非常にまれな症例であったため報告する．

DOI： 10.4009/jsdt.46.949

Low Serum Cultured Adipose Tissue-Derived Stromal Cells Ameliorate Acute Kidney Injury in Rats 査読有り国際誌

Katsuno Takayuki, Ozaki Takenori, Saka Yosuke, Furuhashi Kazuhiro, Kim Hangsoo, Yasuda Kaoru, Yamamoto Tokunori, Sato Waichi, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi

CELL TRANSPLANTATION 22 巻 ( 2 ) 頁： 287 - 297 2013年

Perforative Peritonitis caused by Appendicitis in a Patient on Peritoneal Dialysis 査読有り国際誌

Mizuno Masashi, Suzuki Yasuhiro, Nonaka Keisuke, Sei Yumi, Maruyama Shoichi, Matsuo Seiichi, Ito Yasuhiko

INTERNAL MEDICINE 52 巻 ( 11 ) 頁： 1177 - 1181 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 46-year-old man on peritoneal dialysis (PD) was hospitalized due to suspicious PD-related peritonitis. Because the patient's abdominal pain was unimproved by conventional antibiotics and multiple bacteria were identified in a smear-sample of PD fluid, endogenous peritonitis was suspected. Perforated appendicitis was finally diagnosed under exploratory laparotomy. In this patient, perforated appendicitis was difficult to diagnose due to the attenuated clinical symptoms and inconclusive results of abdominal computed tomography (CT), even though the positive predictive value of CT is >95% in non-PD patients. Quickly deciding to perform exploratory laparotomy in patients suspected of having endogenous peritonitis is thus important, even when the origin has not been clarified.

DOI： 10.2169/internalmedicine.52.9196

Rat adipose tissue-derived stromal cells in a low serum medium attenuate peritoneal injuries in rat zymosan-induced peritonitis 査読有り

PubMed

Kim, H; Mizuno, M; Furuhashi, K; Katsuno, T; Ozaki, T; Yasuda, K; Tsuboi, N; Imai, E; Matsuo, S; Ito, Y; Maruyama, S

IMMUNOBIOLOGY 217 巻 ( 11 ) 頁： 1197 - 1197 2012年11月

Short-term Administration of Diclofenac Sodium Affects Renal Function After Laparoscopic Radical Nephrectomy in Elderly Patients 査読有り国際誌

Mizuno Tomohiro, Ito Kazuma, Miyagawa Yasuhiro, Ishikawa Kazuhiro, Suzuki Yasuhiro, Mizuno Masashi, Ito Yasuhiko, Funahashi Yasuhito, Hattori Ryohei, Gotoh Momokazu, Yamada Kiyofumi, Noda Yukihiro

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 42 巻 ( 11 ) 頁： 1073 - 1078 2012年11月

C5a is a target to prevent peritoneal tissue damage in acute peritoneal injury in rats

Mizuno, T; Mizuno, M; Imai, M; Suzuki, Y; Kushida, M; Yamada, K; Noda, Y; Maruyama, S; Okada, H; Okada, N; Matsuo, S; Ito, Y

IMMUNOBIOLOGY 217 巻 ( 11 ) 頁： 1144 - 1144 2012年11月

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin 査読有り国際誌

ITO Isao, ITO Yasuhiko, MIZUNO Masashi, SUZUKI Yasuhiro, YASUDA Kaoru, OZAKI Takenori, KOSUGI Tomoki, YASUDA Yoshinari, SATO Waichi, TSUBOI Naotake, MARUYAMA Shoichi, IMAI Enyu, MATSUO Seiichi

Clinical and experimental nephrology 16 巻 ( 3 ) 頁： 490 - 494 2012年6月

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin 査読有り国際誌

Ito Isao, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Yasuda Kaoru, Ozaki Takenori, Kosugi Tomoki, Yasuda Yoshinari, Sato Waichi, Tsuboi Naotake, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

CLINICAL AND EXPERIMENTAL NEPHROLOGY 16 巻 ( 3 ) 頁： 490 - 494 2012年6月

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. 国際誌

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 27 巻 ( 6 ) 頁： 2511 - 2516 2012年6月

Transforming growth factor-beta induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction 国際誌

Suzuki Yasuhiro, Ito Yasuhiko, Mizuno Masashi, Kinashi Hiroshi, Sawai Akiho, Noda Yukihiro, Mizuno Tomohiro, Shimizu Hideaki, Fujita Yoshiro, Matsui Katsuyuki, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi, Takei Yoshifumi

KIDNEY INTERNATIONAL 81 巻 ( 9 ) 頁： 865 - 879 2012年5月

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model 査読有り国際誌

Kato Hiroshi, Mizuno Tomohiro, Mizuno Masashi, Sawai Akiho, Suzuki Yasuhiro, Kinashi Hiroshi, Nagura Fumiko, Maruyama Shoichi, Noda Yukihiro, Yamada Kiyofumi, Matsuo Seiichi, Ito Yasuhiko

NEPHROLOGY DIALYSIS TRANSPLANTATION 27 巻 ( 2 ) 頁： 526 - 536 2012年2月

Renal impairment after laparoscopic radical nephrectomy affects hypoglycaemic therapy 査読有り国際誌

Mizuno T., Ito K., Miyagawa Y., Kimura K., Suzuki Y., Mizuno M., Ito Y., Funahashi Y., Hattori R., Gotoh M., Noda Y., Yamada K.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 37 巻 ( 1 ) 頁： 49 - 52 2012年2月

Aliskiren-Induced Chyloperitoneum in a Patient on Peritoneal Dialysis 査読有り国際誌

Y. Saka, H. Tachi, H. Sakurai, M. Tawada, A. Sawai, Y. Shimamura, M. Mizuno, S. Maruyama, S. Matsuo, Y. Ito

PERITONEAL DIALYSIS INTERNATIONAL 32 巻 ( 1 ) 頁： 111 - U123 2012年1月

Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis. et al. A case report. 査読有り

Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.

Perit Dial Int 32 巻頁： 111-113 2012年

Guideline for hereditary angioedema (HAE) 2010 by the Japanese association for complement research. 招待有り査読有り

Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Mizuno M., Nakao M., Okada H., Tsukamoto H., Matsumoto M., Inoue N., Nonaka M., Kinoshita T.

Allergol Int 61 巻 ( 4 ) 頁： 559-562 2012年

Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomu in elderly patients. 査読有り

Mizuno T., Ito K., Miyagawa Y., Ishikawa K., Suzuki Y., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Yamada K., Noda Y.

Jpn J Clin Oncol 42 巻 ( 11 ) 頁： 1073-1078 2012年

Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat. 招待有り査読有り

Mizuno M., Ito Y, Morgan BP.

Marine Drugs 10 巻頁： 1582-1604 2012年

Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts log-term mortality. 査読有り

Takahashi R., Ito Y., Takahashi H., Ishii H., Kasuga H., Mizuno M., Suzuki Y., Yuzawa Y., Maruyama S., Murohara T., Imai E., Matsuo S.

Am J Nephrol 36 巻頁： 136-143 2012年

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. 査読有り

Ito I., Ito Y., Mizuno M., Suzuki Y., Yasuda K., Ozaki T., Kosugi T., Yasuda Y., Sato Y., Tsuboi N., Maruyama S., Imai E., Matsuo S.

Clin Exp Nephrol 16 巻頁： 490-494 2012年

Membrane complement regulators protect against fibrin exudation in a severe peritoneal inflammation model in rats. 査読有り

Mizuno M., Ito Y., Mizuno T., Suzuki Y., Harris CL., Okada N, Matsuo S, Morgan BP.

Am J Physil Renal Physiol 302 巻頁： F1245-F1251 2012年

Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. 査読有り

Suzuki Y., Ito Y., Mizuno M., Kinashi H., Sawai A., Noda Y., Mizuno T., Shimizu H., Fujita Y., Matsui K., Maruyama S., Imai E., Matsuo S., Takei Y.

Kidney Int. 81 巻頁： 865-879 2012年

Renal impairment after laparoscopic radical nephrectomy affects hypoglycemic therapy. 査読有り

Mizuno T., Ito K., Miyagawa Y., Kimura K., Suzuki K., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Noda Y., Yamada K.

J. Clin Pharm Therapy 37 巻頁： 49-52 2012年

Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model. 査読有り

Kato H., Mizuno T., Mizuno M., Sawai A., Suzuki Y., Kinashi H., Nagura F., Maruyama S., Noda Y., Yamada K., Matsuo S., Ito Y.

Nephrol. Dial. Transplant. 27 巻頁： 526-536 2012年

各論２　腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか？本邦のガイドラインをいかにすべきか？招待有り

伊藤恭彦、水野正司、鈴木康弘、清祐実、平松英樹、松尾清一

臨床透析 28 巻頁： 856-864 2012年

至摘透析・体液管理, 腹膜透析における小・中・大分子量物質除去と腹膜機能の関連性

5. 平松英樹、伊藤恭彦、水野正司、鈴木康弘、戸田晋、坪井直毅、伊藤功、佐藤和一、丸山彰一、今井圓裕、林裕樹、松尾清一

腎と透析 2012 （腎と透析　別冊） 73 巻頁： 235-236 2012年

IV. 課題と対策（２）腹膜炎 - 名古屋大学関連施設レジストリーからみたPD腹膜炎の問題点. 招待有り

伊藤恭彦、水野正司、鈴木康弘、他

臨床と透析 28 巻頁： 571-577 2012年

腹膜組織における補体活性化の観点からみた、現在の透析液の問題

水野正司、伊藤恭彦、鈴木康弘、松尾清一

腎と透析 2012 （腎と透析　別冊） 73 巻頁： 109-110 2012年

遺伝子組換えヒトエリスロポエチンによる赤血球造血刺激因子製剤療法低反応性腹膜透析患者の持続型赤血球層血刺激因子製剤Darbepoetin Alfa投与の効果査読有り

平松英樹、林祐樹、水野正司、鈴木康弘、戸田晋、伊藤功、丸山彰一、伊藤恭彦、松尾清一

日本透析医学会会誌 45 巻頁： 247-253 2012年

Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication 国際誌

Horiuchi, T; Ohi, H; Ohsawa, I; Fujita, T; Matsushita, M; Okada, N; Seya, T; Yamamoto, T; Endo, Y; Hatanaka, M; Wakamiya, N; Mizuno, M; Nakao, M; Okada, H; Tsukamoto, H; Matsumoto, M; Inoue, N; Nonaka, M; Kinoshita, T

ALLERGOLOGY INTERNATIONAL 61 巻 ( 4 ) 頁： 559 - 562 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本アレルギー学会

This guideline was provided by the Japanese Association for Complement Research targeting clinicians for making an accurate diagnosis of hereditary angioedema (HAE), and for prompt treatment of the HAE patient in Japan. This is a 2010 year version and will be updated according to any pertinent medical advancements.

DOI： 10.2332/allergolint.12-rai-0471

遺伝子組換えヒトエリスロポエチンによる赤血球造血刺激因子製剤療法低反応性腹膜透析患者の持続型赤血球造血刺激因子製剤Darbepoetin Alfa投与の効果国際共著

平松英樹, 林裕樹, 水野正司, 鈴木康弘, 戸田晋, 伊藤功, 丸山彰一, 伊藤恭彦, 松尾清一

日本透析医学会雑誌 45 巻 ( 3 ) 頁： 247 - 253 2012年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

腹膜透析（peritoneal dialysis：PD）患者において遺伝子組換えヒトエリスロポエチン（recombinant human erythropoietin：rHuEPO）投与量は，最大24,000単位/月（12,000単位/2週または6,000単位/週）であるが，十分な貧血改善効果が得られない症例もみられる．われわれは，当院PD患者46名を対象とし，rHuEPOによりヘモグロビン値（Hb値）が，10g/dL以上に到達できなかった赤血球造血刺激因子製剤（erythropoiesis stimulation agent：ESA）療法低反応性PD患者8名について，Darbepoetin Alfa（DA）投与の効果を検討しDA投与が必要であった患者群（DA群）は，DA非投与の患者群と比べると腹膜透析歴が有意に長期であった．また，DA群で残腎機能は有意に低下しており，中分子量物質除去の指標であるβ2-ミクログロブリン値（β2-MG）は高値であった．また，炎症の指標であるCRP値は，DA群で有意に高値であった．両群のフェリチン値に差はなかった．DA群では，rHuEPO投与からDAへ変更したことにより，投与開始時のHb値9.1±0.8g/dL（平均±標準偏差）から投与18週後にHb値11.0±0.8g/dLへ有意に改善し，また，長期投与により全例が目標Hb値の11g/dL以上となった．なお，DA投与量は，投与開始時67.5±19.8μg/回/2週から100±18.5μg/回/2週（投与18週）への増量が必要であった．rHuEPOで十分な貧血改善が得られないESA療法低反応性PD患者においても高用量のDA投与により，Hb値の改善が全例可能であったことより，当院のESA低反応症例は，ESA投与量の絶対量不足が原因と考えられた．

DOI： 10.4009/jsdt.45.247

Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality 査読有り国際誌

Takahashi Ryo, Ito Yasuhiko, Takahashi Hiroshi, Ishii Hideki, Kasuga Hirotake, Mizuno Masashi, Suzuki Yasuhiro, Yuzawa Yukio, Maruyama Shoichi, Murohara Toyoaki, Imai Enyu, Matsuo Seiichi

AMERICAN JOURNAL OF NEPHROLOGY 36 巻 ( 2 ) 頁： 136 - 143 2012年

腹膜組織における補体活性化の観点からみた、現在の透析液の問題

水野正司, 伊藤恭彦, 鈴木康弘, 松尾清一

腎と透析 2012 （腎と透析別冊） 73 巻頁： 109-110 2012年

平松英樹, 林祐樹, 水野正司, 鈴木康弘, 戸田晋, 伊藤功, 丸山彰一, 伊藤恭彦, 松尾清一

日本透析医学会会誌 45 巻頁： 247-253 2012年

各論２腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか？本邦のガイドラインをいかにすべきか？招待有り

伊藤恭彦, 水野正司, 鈴木康弘, 清祐実, 平松英樹, 松尾清一

臨床透析 28 巻頁： 856-864 2012年

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis 査読有り国際誌

SUZUKI Yasuhiro, MIZUNO Masashi, NAKASHIMA Ryoko, HIRAMATSU Hideki, TODA Susumu, SATO Waichi, TSUBOI Naotake, ITO Isao, MARUYAMA Shoichi, IMAI Enyu, MATSUO Seiichi, ITO Yasuhiko

Clinical and experimental nephrology 15 巻 ( 6 ) 頁： 962 - 965 2011年12月

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis 査読有り国際誌

Suzuki, Y; Mizuno, M; Nakashima, R; Hiramatsu, H; Toda, S; Sato, W; Tsuboi, N; Ito, I; Maruyama, S; Imai, E; Matsuo, S; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 15 巻 ( 6 ) 頁： 962 - 965 2011年12月

MIZUNO Masashi, ITO Yasuhiko, TANAKA Akio, SUZUKI Yasuhiro, HIRAMATSU Hideki, WATANABE Midoriko, TSURUTA Yoshikazu, MATSUOKA Teppei, ITO Isao, TAMAI Hiroshi, KASUGA Hirotake, SHIMIZU Hideaki, KURATA Hisashi, INAGUMA Daijo, HIRAMATSU Takeyuki, HORIE Masanobu, NARUSE Tomohiko, MARUYAMA Shoichi, IMAI Enyu, YUZAWA Yukio, MATSUO Seiichi

Clinical and experimental nephrology 15 巻 ( 5 ) 頁： 727 - 737 2011年10月

Non-physiological osmolarity and pH in peritoneal dialysis fluid impair complement regulation in rat peritoneal mesothelial cells 国際共著国際誌

Mizuno, M; Mizuno, T; Ito, Y; Suzuki, Y; Kinashi, H; Noda, Y; Yamada, K; Okada, N; Morgan, BP; Matsuo, S

MOLECULAR IMMUNOLOGY 48 巻 ( 14 ) 頁： 1690 - 1690 2011年8月

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. 査読有り

Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S

26 巻 ( 7 ) 頁： 2322-2332 2011年7月

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients 査読有り国際誌

Sawai Akiho, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Hattori Ryohei, Matsukawa Yoshihisa, Gotoh Momokazu, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

NEPHROLOGY DIALYSIS TRANSPLANTATION 26 巻 ( 7 ) 頁： 2322 - 2332 2011年7月

Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation 査読有り国際共著国際誌

Mizuno, T; Mizuno, M; Morgan, BP; Noda, Y; Yamada, K; Okada, N; Yuzawa, Y; Matsuo, S; Ito, Y

NEPHROLOGY DIALYSIS TRANSPLANTATION 26 巻 ( 6 ) 頁： 1821 - 1830 2011年6月

A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis. 査読有り

Mizuno M., Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Intern Med 50 巻頁： 471-474 2011年

Lymphangiogenesis develop during tubulo-interstitial fibrosis via TGF-beta VEGF-C pathway in rat unilateral ureteral obstruction. 査読有り

Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Noda Y, Kato H, Shimizu H, Fujita Y, Matsui K, Imai E, Yuzawa Y, Matsuo S, Takei Y.

Kidney Int ??? in press 巻頁： ???????? 2011年

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. 査読有り

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Nephrol Dial Transplant ?? 巻頁： ?????? in press 2011年

A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis. 査読有り

Suzuki Y., Mizuno M., Nakashima R., Hiramatsu H., Toda S., Sato W., Tsuboi N., Ito I., Maruyama S., Imai E., Matsuo S., Ito Y.

Clin Exp Nephrol 15 巻頁： 962-965 2011年

A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. 査読有り

Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

Intern Med 50 巻頁： 1719-1723 2011年

A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. 査読有り

Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

Intern Med 50 巻頁： 1719-1723 2011年

腹膜透析にかかわる腹膜組織障害における補体の関与招待有り

水野正司、伊藤恭彦、松尾清一

医学のあゆみ 239 巻頁： 779-783 2011年

残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響査読有り

柴田佳菜子、伊藤恭彦、水野正司、鈴木康弘、平松英樹、伊藤功、戸田晋、丸山彰一、中尾誠、松尾清一

日本透析医学会会誌 44 巻頁： 1007-1013 2011年

Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis 査読有り国際誌

Mizuno, M; Ito, Y; Masuda, T; Toda, S; Hiramatsu, H; Suzuki, Y; Ozaki, T; Yasuda, Y; Ito, I; Tsuboi, N; Sato, W; Maruyama, S; Imai, E; Matsuo, S

INTERNAL MEDICINE 50 巻 ( 5 ) 頁： 471 - 474 2011年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本内科学会

A 54-year-old woman on peritoneal dialysis (PD) was hospitalized with peritonitis with a high body temperature, abdominal pain and cloudy peritoneal fluid. She progressively fell into septic-like shock within only 6 hours after onset. The causative bacteria were Streptococcus mitis (S. mitis), part of the normal flora of oral cavity, intestine, female genial tract and upper respiratory tract. S. mitis shows pathogenicity for diseases such as endocarditis, brain abscesses and sepsis in children with malignancy or transplantation. However, S. mitis rarely shows severe pathogenic responses in adults. We report herein a case of fulminant peritonitis caused by S. mitis in an adult PD patient.

DOI： 10.2169/internalmedicine.50.4122

残腎機能を有する腹膜透析患者に対するシナカルセト投与時のＭｇ，Ｋ代謝に及ぼす影響国際誌

柴田佳菜子, 伊藤恭彦, 水野正司, 鈴木康弘, 平松英樹, 伊藤功, 戸田晋, 丸山彰一, 松尾清一

日本透析医学会雑誌 44 巻 ( 10 ) 頁： 1007 - 1013 2011年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

二次性副甲状腺機能亢進症（2°HPT）の治療薬であるシナカルセトは副甲状腺のカルシウムセンシングレセプター（CaSR）に結合することにより，副甲状腺ホルモン（PTH）の分泌を抑制する．CaSRは副甲状腺のみならず，腎臓や骨，脳など全身に発現している．腎臓では，ヘンレループの上行脚や集合管に発現しているため，CaSRを介したマグネシウム（Mg），カリウム（K）代謝への影響が考えられる．腹膜透析（PD）は残腎機能保持が特徴であり，尿量が維持されているPD患者は多い．今回，残腎機能を有するPD患者へのシナカルセト投与の有用性，およびMg，K代謝を含めた安全性を検討した．残腎機能を有するPD患者6名を対象として，シナカルセト投与前と投与2か月後のintact PTH（iPTH），血清Ca値，血清P値，血清Mg値，血清K値，およびそれぞれの尿中排泄量の変化を検討した．また，腎機能の評価とシナカルセト服用中の有害事象，併用薬の調査を行った．シナカルセト投与により，血清iPTH値，血清P値，尿中P排泄量が有意に低下した．iPTHは中央値427.2（Interquatile range；IQR：351.2～1,313.3）pg/mLから中央値234.4（IQR：86.0～721.3）pg/mLに有意に減少した．一方，血清Ca値，血清Mg値，血清K値，Ca，Mg，Kの尿中排泄量には著明な変化はみられなかった．治療前後の血清Mg値，血清K値の中央値はそれぞれ2.2（IQR：1.9～2.3）mg/dLから2.0（IQR：1.8～2.5）mg/dL，4.5（IQR：4.4～5.2）mEq/Lから4.6（IQR：4.2～4.8）mEq/Lで，いずれも基準値内で有意な変化を示さなかった．シナカルセト投与による血清Mg，K濃度への影響は認められず，残腎機能を有するPD患者に対しても安全に使用できることが示唆された．

DOI： 10.4009/jsdt.44.1007

A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. 国際誌

Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Mizuno T, Tatematsu M, Ozaki T, Yasuda Y, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S

Internal medicine (Tokyo, Japan) 50 巻 ( 16 ) 頁： 1719 - 1723 2011年

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. 査読有り国際誌

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S

Nephrol Dial Transplant ?? 巻頁： ?????? in press 2011年

残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響査読有り

柴田佳菜子, 伊藤恭彦, 水野正司, 鈴木康弘, 平松英樹, 伊藤功, 戸田晋, 丸山彰一, 中尾誠, 松尾清一

日本透析医学会会誌 44 巻頁： 1007-1013 2011年

Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient. 査読有り国際誌

Yuzawa Y, Ito Y, Mizuno M, Sawai A, Matsuo S

NDT plus 3 巻 ( 4 ) 頁： 372 - 5 2010年8月

Membrane complement regulators may protect against encapsular peritoneal sclerosis (EN) in a chronic proliferative peritoneal inflammation model of zymosan peritonitis in the rat 国際共著国際誌

Mizuno, M; Ito, Y; Mizuno, T; Suzuki, Y; Noda, Y; Yamada, K; Harris, CL; Okada, N; Morgan, BP; Matsuo, S

MOLECULAR IMMUNOLOGY 47 巻 ( 13 ) 頁： 2270 - 2270 2010年8月

[Recent knowledge of complement system and the protective roles]. 招待有り

Mizuno M, Matsuo S

Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 巻頁： 49 - 52 2010年6月

Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate 査読有り国際共著国際誌

Mizutani Makoto, Ito Yasuhiko, Mizuno Masashi, Nishimura Hayato, Suzuki Yasuhiro, Hattori Ryohei, Matsukawa Yoshihisa, Imai Masaki, Oliver Noelynn, Goldschmeding Roel, Aten Jan, Krediet Raymond T., Yuzawa Yukio, Matsuo Seiichi

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 298 巻 ( 3 ) 頁： F721 - F733 2010年3月

IX. 免疫学的検査　C. 補体および関連物質, 概論：補体系の機能と生体防御に果たす役割招待有り

水野正司、松尾清一

日本臨床 68 巻頁： 49-52 2010年

Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. 査読有り

Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S.

Intern Med 49 巻頁： 1139-1142 2010年

Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. 査読有り

Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol 298 巻 ( F721-F733 ) 2010年

名大腎不全システム研究会レジストリによる東海地区13施設の３年間（2005～2007）解析から得た、現在の腹膜透析療法の傾向と問題点

2. 水野正司、伊藤恭彦、田中章郎、平松英樹、渡辺緑子、稲熊大城、戸田晋、檀原敦、玉井宏史、倉田久嗣、春日弘毅、志水英明、松岡哲平、鶴田吉和、堀江正宣、成瀬友彦、平松武幸、伊藤功、丸山彰一、湯澤由紀夫、松尾清一

腎と透析 2010 （腎と透析別冊） 69 巻頁： 638-640 2010年

基礎カンファレンス　腹膜線維化に関する基礎研究の進歩, 腹膜線維症・機能不全と成長因子　特にTGF-β/CTGF/VEGFからの検討

3. 伊藤恭彦、水野正司、水谷真、西村勇人、鈴木康弘、澤井晶穂、鬼無洋、湯澤由紀夫、松尾清一

腎と透析 2010（腎と透析　別冊） 69 巻頁： 128-131 2010年

IX.免疫学的検査C.補体および関連物質招待有り査読有り

水野正司, 松尾清一

日本臨床 Vol.68 巻頁： 49 - 52 2010年

名大腎不全システム研究会レジストリによる東海地区13施設の3年間(2005～2007)解析から得た、現在の腹膜透析療法の傾向と問題点査読有り

水野正司, 伊藤恭彦, 松尾清一

腎と透析2010 Vol.69 巻頁： 638 - 640 2010年

基礎カンファレンス腹膜線維化に関する基礎研究の進歩、腹膜線維症・機能不全と成長因子

伊藤恭彦, 水野正司, 松尾清一

腎と透析2010 Vol.69 巻頁： 128 - 131 2010年

Acute Kidney Injury Presenting a Feature of Leukemic Infiltration during Therapy for Chronic Myelogenous Leukemia 国際誌

Yuzawa, Y; Sato, W; Masuda, T; Hamada, Y; Tatematsu, M; Yasuda, Y; Ozaki, T; Ito, I; Mizuno, M; Maruyama, S; Ito, Y; Matsuo, S

INTERNAL MEDICINE 49 巻 ( 12 ) 頁： 1139 - 1142 2010年

基礎カンファレンス腹膜線維化に関する基礎研究の進歩, 腹膜線維症・機能不全と成長因子特にTGF-β/CTGF/VEGFからの検討

伊藤恭彦, 水野正司, 水谷真, 西村勇人, 鈴木康弘, 澤井晶穂, 鬼無洋, 湯澤由紀夫, 松尾清一

腎と透析 2010（腎と透析別冊） 69 巻頁： 128-131 2010年

名大腎不全システム研究会レジストリによる東海地区13施設の３年間（2005～2007）解析から得た、現在の腹膜透析療法の傾向と問題点

水野正司, 伊藤恭彦, 田中章郎, 平松英樹, 渡辺緑子, 稲熊大城, 戸田晋, 檀原敦, 玉井宏史, 倉田久嗣, 春日弘毅, 志水英明, 松岡哲平, 鶴田吉和, 堀江正宣, 成瀬友彦, 平松武幸, 伊藤功, 丸山彰一, 湯澤由紀夫, 松尾清一

腎と透析 2010 （腎と透析別冊） 69 巻頁： 638-640 2010年

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. 査読有り国際誌

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S

American journal of physiology. Renal physiology 297 巻 ( 6 ) 頁： F1510 - 7 2009年12月

Specific collaboration between rat membrane complement regulators, Crry and CD59, protects peritoneum from damage by autologous complement activation in peritoneal dialysate fluid

Mizuno, T; Mizuno, M; Morgan, BP; Okada, N; Noda, Y; Yuzawa, Y; Matsuo, S; Ito, Y

MOLECULAR IMMUNOLOGY 46 巻 ( 14 ) 頁： 2859 - 2860 2009年9月

Lymphatic vessels develop during tubulointerstitial fibrosis 査読有り国際誌

Sakamoto Izumi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sawai Akiho, Tanaka Akio, Maruyama Shoichi, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

KIDNEY INTERNATIONAL 75 巻 ( 8 ) 頁： 828 - 838 2009年4月

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. 査読有り

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol 297 巻 ( F1510-1517 ) 2009年

Lymphatic vessels develop during tubulointerstitial fibrosis. 査読有り

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney Int 75 巻頁： 828-838 2009年

The role of membrane complement regulators in the normal peritoneal cavity

Mizuno, T; Mizuno, M; Ito, Y; Matsuo, S; Noda, Y

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 巻頁： 59P - 59P 2009年

Zymosan, but not LPS, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model initiated by mechanical scraping 査読有り国際共著国際誌

Mizuno, M; Ito, Y; Mizuno, T; Harris, CL; Morgan, BP; Hepburn, N; Nishimura, H; Matsuo, S

MOLECULAR IMMUNOLOGY 45 巻 ( 16 ) 頁： 4153 - 4154 2008年10月

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model 査読有り国際誌

Nishimura Hayato, Ito Yasuhiko, Mizuno Masashi, Tanaka Akio, Morita Yoshiki, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 294 巻 ( 5 ) 頁： F1084 - F1093 2008年5月

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. 査読有り

Donev RM., Sivasankar B., Mizuno M., Morgan BP.

Mol. Immunol. 45 巻頁： 534-542 2008年1月

The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. 査読有り国際共著国際誌

Donev RM, Sivasankar B, Mizuno M, Morgan BP

Molecular immunology 45 巻 ( 2 ) 頁： 534 - 542 2008年1月

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. 査読有り

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

Am J Physiol Renal Physiol 294 巻頁： F1084-F1093 2008年

『特集　アシドーシスとアルカローシス』代謝性酸塩基平衡異常における治療の基本とその方法招待有り

伊藤恭彦、水野正司

薬局 59 巻頁： 42-47 2008年

本邦のCAPD療法の現況　–　CAPD療法に対する取り組み　大学・教育病院の役割招待有り

伊藤恭彦、水野正司、丸山彰一、湯澤　由紀夫、松尾清一

臨床透析 24 巻頁： 205-210 2008年

Complement C3a receptor was highly found in the glomeruli of inflamed human lupus nephritis 国際共著国際誌

Mizuno, M; Blanchin, S; Gasque, P; Nishikawa, K; Matsuo, S

MOLECULAR IMMUNOLOGY 44 巻 ( 16 ) 頁： 3953 - 3953 2007年9月

CD59b is abundantly expressed only in testis and plays a role in acrosome activation and spermatozoal motility 査読有り国際共著国際誌

Donev, RM; Sivasankar, B; Mizuno, M; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 16 ) 頁： 3956 - 3956 2007年9月

A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a renal injury resembling haemolytic uremic syndrome. 査読有り

Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan BP., Matsuo S.

Am. J. Pathol. 171 巻頁： 402-414 2007年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Envenomation by the sea anemone Phyllodiscus semoni causes fulminant dermatitis and, rarely, acute renal failure in humans. Here, we investigated whether the venom extracted from the nematocysts (PsTX-T) was nephrotoxic when administered intravenously in rats and whether PsTX-T induced activation of the complement system. Although small dose of PsTX-T induced acute tubular necrosis in rats resembling pathology seen in patients, kidneys displayed glomerular injury with glomerular endothelial damage, thrombus formation, mesangiolysis, and partial rupture of glomerular basement membrane, accompanied by severe tubular necrosis at 24 hours after administration of 0.03 mg of PsTX-T per animal, similar to the glomerular findings typical of severe hemolytic uremic syndrome. The early stage injury was accompanied by specific PsTX-T binding, massive complement C3b, and membrane attack complex deposition in glomeruli in the regions of injury and decreased glomerular expression of complement regulators. A pathogenic role for complement was confirmed by demonstrating that systemic complement inhibition reduced renal injury. The isolated nephrotoxic component, a 115-kd protein toxin (PsTX-115), was shown to cause identical renal pathology. The demonstration that PsTX-T and PsTX-115 were highly nephrotoxic acting via induction of complement activation suggests that inhibition of complement might be used to prevent acute renal damage following envenomation by P. semoni.

CD55 in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa 国際共著国際誌

Mizuno, M; Donev, RM; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 7 ) 頁： 1613 - 1622 2007年3月

Immunisation with CD46 generates a strong autoantibody response targeting the spermatozoal acrosome in rat

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 44 巻 ( 1-3 ) 頁： 216 - 216 2007年1月

High levels of complement C3a receptor in the glomeruli of inflamed human lupus nephritis. 査読有り

Mizuno M., Blanchin S., Gasque P., Nishikawa K., Matsuo S.

Am. J. Kidney Dis. 49 巻頁： 598-606 2007年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states. METHODS: Several antibodies were generated and used for immunohistochemistry and Western blot analyses to address C3aR expression and its regulation in vitro on cell lines of myeloid cells and nonmyeloid cell lineages. Furthermore, C3aR distribution was investigated in control nephrectomized kidneys and 116 biopsy specimens from patients with renal diseases, including lupus nephritis (lupus-N). RESULTS: C3aR is a highly N-glycosylated protein with an apparent molecular mass of 65 to 95 kd expressed by myeloid and endothelial cells. C3aR is particularly upregulated in response to interferon gamma treatment, but was unaffected by the other inflammatory cytokines, such as tumor necrosis factor alpha and transforming growth factor beta. In normal human kidney, C3aR staining was not observed. However, glomerular C3aR staining was detected in 42.9% of lupus-N specimens in association with immunoglobulin G immune-complex depositions. Staining intensity correlated with disease severity. C3aR was found in the endothelial area of 81.3% of samples classified as World Health Organization class IV with active lesions. Conversely, C3aR was not detected by means of immunohistochemistry in kidneys from patients with other renal diseases. CONCLUSION: Our data indicate that C3aR expression is tightly regulated and altered in certain disease conditions. C3aR may be used as a unique biomarker of diagnosis and disease activity in patients with lupus-N.

よく使う利尿薬について習熟する　スピロノラクトン招待有り

水野正司、伊藤恭彦

Medicina 44 巻頁： 359-342 2007年

Immunization with autologous CD46 in rats generates a strong autoantibody response that targets spermatozoa. 査読有り

Mizuno M., Harris CL., Morgan BP.

J. Reprod. Immunol. 73 巻頁： 135-147 2007年

【特集:これだけは知っておきたい分子腎臓学2007】 C5a. 招待有り

水野正司、湯澤由紀夫、松尾清一

腎と透析 63 巻頁： 580-582 2007年

Complement membrane attack is required for endplate damage and clinical disease in passive experimental myasthenia gravis in Lewis rats 査読有り国際共著国際誌

J. Chamberlain-Banoub, J. W. Neal, M. Mizuno, C. L. Harris, B. P. Morgan

CLINICAL AND EXPERIMENTAL IMMUNOLOGY 146 巻 ( 2 ) 頁： 278 - 286 2006年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular endplate with resultant failure of neuromuscular transmission. A role for complement (C) in the pathology of human MG has been suggested based upon identification of C activation products in plasma and deposited at the endplate in MG. In the rat model, experimental autoimmune MG (EAMG), C depletion or inhibition restricts clinical disease, further implicating C in pathology. The mechanisms by which C activation drives pathology in MG and EAMG are unclear. Here we provide further evidence implicating C and specifically the membrane attack complex (MAC) in the Lewis rat passive EAMG model of MG. Rats deficient in C6, an essential component of the MAC, were resistant to disease induction and endplate destruction was reduced markedly compared to C6-sufficient controls. After reconstitution with C6, disease severity and endplate destruction in the C6-deficient rats was equivalent to that in controls. The data confirm the essential role of the MAC in the destruction of the endplate in EAMG and raise the prospect of specific MAC inhibition as an alternative therapy in MG patients resistant to conventional treatments.

DOI： 10.1111/j.1365-2249.2006.03198.x

The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice 査読有り国際共著国際誌

B. P. Morgan, J. Chamberlain-Banoub, J. W. Neal, W. Song, M. Mizuno, C. L. Harris

CLINICAL AND EXPERIMENTAL IMMUNOLOGY 146 巻 ( 2 ) 頁： 294 - 302 2006年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

The human neuromuscular disease myasthenia gravis (MG) is characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular end-plate with resultant failure of neuromuscular transmission. A role for complement (C) in AChR loss has been suggested based uponmorphological identification of C at the end-plate in MG and from the effects of C inhibition in murine models. Here we provide further evidence implicating C, and specifically the membrane attack complex (MAC), in a mouse model of MG. Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model. Wild-type mice were resistant to disease while mice deficient in Daf1 had mild disease symptoms with evidence of C activation and AChR loss at end-plates. Cd59a-deficient mice had very mild disease with some muscle inflammation and essentially undamaged end-plates. In contrast, mice deficient in both C regulators developed a severe paralytic disease with marked muscle inflammation and loss of end-plates. Inhibition of MAC assembly abrogated clinical disease in these double-deficient mice, demonstrating conclusively that MAC formation was driving pathology in the model. These findings provoke us to suggest that current anti-C therapeutics targeting MAC assembly will be beneficial in MG patients resistant to conventional therapies.

DOI： 10.1111/j.1365-2249.2006.03205.x

Stage-specific expression of CD55 isoforms during spermiogenesis in the rat

Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury.

Mizuno M, Harris CL, Morgan BP

Journal of reproductive immunology 69 巻 ( 1 ) 頁： 23 - 34 2006年2月

Complement and complement regulators in the male reproductive system. 査読有り国際共著国際誌

Harris CL, Mizuno M, Morgan BP

Molecular immunology 43 巻 ( 1-2 ) 頁： 57 - 67 2006年1月

Mizuno, M; Harris, CL; Donev, RM; Spiller, OB; Morgan, BP

MOLECULAR IMMUNOLOGY 43 巻 ( 1-2 ) 頁： 156 - 156 2006年1月

The membrane attack pathway of complement drives pathology in experimental autoimmune myasthenia gravis in mice. 査読有り

Morgan BP., Chamberlain-Banoub J., Neal JW.,Song W., Mizuno M., Harris CL.

Clin Exp Immunol 146 巻頁： 294-302 2006年

Complement and complement regulators in the male reproductive system. 招待有り査読有り

Harris CL., Mizuno M., Morgan BP.

Mol Immunol 43 巻頁： 57-67 2006年

Complement membrane attack is required for endplate damage and clinical disease in experimental myasthenia gravis in Lewis rats. 査読有り

Chamberlain-Banoub J., Neal JW., Mizuno M., Harris CL., Morgan BP.

Clin Exp Immunol 146 巻頁： 278-286 2006年

CD55 expression in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa. 査読有り

Mizuno M., Donev RM., Harris CL., Morgan BP.

Mol. Immunol. 44 巻頁： 1624-1633 2006年

A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis. 招待有り査読有り

Mizuno M.

Curr Med Chem 13 巻頁： 1707-1717 2006年

Unique expression patterns of membrane complement regulators and C3 in rat testes and spermatozoa delineate the blood-testis barrier and suggest distinct functional roles in germ cell development. 査読有り

Mizuno M., Harris CL., Morgan BP.

J Reprod Immunol 69 巻頁： 23-34 2006年

Mizuno M, Harris CL, Morgan BP

J Reprod Immunol 69 巻頁： 23-34 2006年

Shiga toxin 1causes direct renal injury in rats 査読有り国際誌

Yamamoto ET, Mizuno M, Nishikawa K, Miyazawa S, Zhang LS, Matsuo S, Natori Y

INFECTION AND IMMUNITY 73 巻 ( 11 ) 頁： 7099 - 7106 2005年11月

Novel C5a regulators in inflammatory disease. 招待有り査読有り国際誌

Mizuno M, Cole DS

Expert opinion on investigational drugs 14 巻 ( 7 ) 頁： 807 - 821 2005年7月

Expression of CD46 in developing rat spermatozoa: ultrastructural localisation and utility as a marker of the various stages of the seminiferous tubuli. 査読有り

Mizuno M., Harris CL., Suzuki N., Matsuo S., Morgan BP.

Biol Reprod 72 巻頁： 908-915 2005年

Shiga toxin-1 causes direct renal injury in rats. 査読有り

Yamamoto ET., Mizuno M., Nishikawa K., Miyazawa S., Zhang L., Matsuo S., Natori Y.

Infect Immun 73 巻頁： 7099-7106 2005年

Novel C5a regulators in inflammation. 招待有り査読有り

Mizuno M., Cole DS.

Expert Opin Investig Drugs 14 巻頁： 807-821 2005年

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, Morgan BP

Journal of immunology (Baltimore, Md. : 1950) 173 巻 ( 6 ) 頁： 3684 - 92 2004年9月

Inummohistochemical analysis of membrane complement regulatory proteins in rat testis: unique roles for DAF and MCP in spermatozoal function?

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 41 巻 ( 2-3 ) 頁： 280 - 280 2004年6月

The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. 招待有り査読有り

Mizuno M., Morgan BP.

Current Drug Targets Inflammation & Allergy 3 巻頁： 85-94 2004年

CD59a is the primary regulator of membrane attack complex assembly in the mouse. 査読有り

Baalasubramanian S., Harris CL., Donev RM., Mizuno M., Omidvar N., Song W., Morgan BP.

J. Immunol. 173 巻頁： 3684-3692 2004年

Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. 査読有り

Mizuno M., Harris CL., Johnson PM., Morgan BP.

Biol Reprod 71 巻頁： 1374-1383 2004年

Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. 査読有り

Williams AS., Mizuno M., Richards PJ., Holt DS., Morgan BP

Arthritis Rheum 50 巻頁： 3035-3044 2004年

In two patients on long-term hemodialysis, Etidronate Disodium improved their discomfort and extremities' blood flow associated with severe abnormal arterial wall calcification. 査読有り

Mizuno M., Kashima N., Kato K., Ito A, Matsuo S.

Clin Drug Invest 24 巻頁： 365-371 2004年

Improvement in Discomfort and Decreased Blood Flow Associated with Severe Arterial Wall Calcification following Etidronic Acid. 査読有り国際誌

Mizuno M, Kashima N, Kato K, Ito A, Matsuo S

Clinical drug investigation 24 巻 ( 6 ) 頁： 365 - 71 2004年

Implication of the complement system in the induction of antiglomerular basement membrane glomerulonephritis in WKY rats 査読有り国際誌

SHIKE Tatsuhiko, ISOME Masato, MIZUNO Masashi, SUZUKI Junzo, MATSUO Seiichi, YAMAMOTO Tadashi, SUZUKI Hitoshi

Pathology international 53 巻 ( 11 ) 頁： 757 - 761 2003年11月

Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats.

Shike T, Isome M, Mizuno M, Suzuki J, Matsuo S, Yamamoto T, Suzuki H

Pathology international 53 巻 ( 11 ) 頁： 757 - 61 2003年11月

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids

LIU Man-Chang, MARUYAMA Shoichi, MIZUNO Masashi, MORITA Yoshiki, HANAKI Shigeru, YUZAWA Yukio, MATSUO Seiichi

Clinical and experimental nephrology 7 巻 ( 3 ) 頁： 186 - 194 2003年9月

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. 査読有り国際誌

Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S

Clinical and experimental nephrology 7 巻 ( 3 ) 頁： 186 - 194 2003年9月

Membrane cofactor protein (MCP; CD46) in the rat is expressed only in male germ cells and precursors

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 40 巻 ( 2-4 ) 頁： 202 - 203 2003年9月

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison.

Harris CL, Hanna SM, Mizuno M, Holt DS, Marchbank KJ, Morgan BP

Immunology 109 巻 ( 1 ) 頁： 117 - 26 2003年5月

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison 査読有り国際共著国際誌

CL Harris, SM Hanna, M Mizuno, DS Holt, KJ Marchbank, BP Morgan

IMMUNOLOGY 109 巻 ( 1 ) 頁： 117 - 126 2003年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING LTD

CD59, the sole membrane regulator of the membrane attack complex of complement, is broadly and abundantly expressed in man and other mammals. In mouse, CD59 is encoded by two homologous genes. The expression patterns and functional roles of the proteins encoded by these genes, mCD59a and mCD59b, have not been well characterized. Here we describe the generation of monoclonal and polyclonal antibodies detecting specifically mCD59a and mCD59b. These reagents have been used to study function and to ascertain the cell and tissue distributions of mCD59a and mCD59b. mCD59a was broadly distributed on endothelia, erythrocytes, platelets, and on numerous other cell types in organs, a distribution pattern resembling that of CD59 in other species. In marked contrast, expression of mCD59b was restricted to germ cell elements in the testis and mature spermatozoa. Both mCD59a and CD59b inhibited human and rodent complement with similar efficiency. These findings demonstrate that the broadly distributed mCD59a is the key regulator of the terminal complement pathway in mice whereas CD59b, expressed only in testis and on sperm, probably plays other roles in vivo.

高脂血症を伴う長期維持血液透析患者におけるポリスルフォン膜 (PS-UW) の有用性について査読有り

Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients 査読有り国際誌

Liu MC, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S

NEPHROLOGY DIALYSIS TRANSPLANTATION 18 巻 ( 3 ) 頁： 563 - 569 2003年3月

Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients. 査読有り

Liu M., Takahashi H., Morita Y., Maruyama S., Mizuno M., Yuzawa Y., Watanabe M., Toriyama T., Kawahara H., MatsuoS.

Nephrol Dial Transplant. 18 巻頁： 563-569 2003年

Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats. Pathol. 査読有り

Shike T., Isome M., Mizuno M., Suzuki J., Matsuo S., Yamamoto T., Suzuki H.

Pathol. Int. 53 巻頁： 757-761 2003年

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. 査読有り

Liu MC., Maruyama S., Mizuno M., Morita Y., Hanaki S., Yuzawa Y., Matsuo, S.

Clin Exp Nephrol 7 巻頁： 186-194 2003年

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. 査読有り

Harris CL., Hanna SM., Mizuno M., Holt DS., Marchbank KJ., Morgan BP.

Immunology 109 巻頁： 117-126 2003年

Nephrogenic diabetes insipidus associated with hemochromatosis 査読有り国際誌

Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M, Mizuno M, Oiso Y, Yamamoto M

AMERICAN JOURNAL OF KIDNEY DISEASES 40 巻 ( 2 ) 頁： 403 - 406 2002年8月

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction 査読有り国際誌

Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S

KIDNEY INTERNATIONAL 62 巻 ( 1 ) 頁： 94 - 105 2002年7月

水野正司, 小林薫, 中田敦博, 渡辺緑子, 鳥山高伸, 川原弘久, 松尾清一

日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 35 巻 ( 1 ) 頁： 43 - 49 2002年1月

Soluble complement receptor type 1 protects rats from lethal shock induced by anti-Crry antibody following lipopolysaccharide priming

Mizuno M, Nishikawa K, Okada N, Matsuo S, Okada H

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 127 巻 ( 1 ) 頁： 55 - 62 2002年1月

Soluble complement receptor type 1 protects rats from lethal shock induced by anti-Crry antibody following lipopolysaccharide priming.

Mizuno M, Nishikawa K, Okada N, Matsuo S, Okada H

International archives of allergy and immunology 127 巻 ( 1 ) 頁： 55 - 62 2002年1月

高脂血症を伴う長期維持血液透析患者におけるポリスルフォン膜(PS-UW)の有用性について査読有り

水野正司、小林薫、中田淳博、渡辺緑子、鳥山高伸、川原弘久、松尾清一

日本透析医学会雑誌 35 巻頁： 43-49 2002年

二次性副甲状腺機能亢進症に対するmaxacalcitorol（オキサロールＲ）静注パルス療法の効果 ―早期低用量使用の試みー査読有り

渡辺緑子、中田敦博、八島影人、河出恭雅、佐藤悌、小杉智規、鳥山高伸、河原弘久、水野正司、森田良樹、松尾清一

日本透析医学会誌 35 巻頁： 1193-1250 2002年

Soluble CR1 protects rats from lethal shock induced by anti-Crry antibody following LPS priming. 査読有り

Mizuno M., Nishikawa K., Okada N., Mastuo S., Okada H.

Internal. Arch. Allergy Immunol. 127 巻頁： 55-62 2002年

Nephrogenic diabetes insipidus associated with hemochromatosis. 査読有り

Okumura A., Kondo K., Hirai C., Nishimura H., Tamai H., Kawarazaki F., Ichikaraki M., Mizuno M., Oiso Y., Yamamoto M.

Am J Kidney Dis 40 巻頁： 403-406 2002年

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. 査読有り

Naruse T., Yuzawa Y., Akahori T, Mizuno M., Maruyama S., Kannagi R., Hotta S., Matsuo S.

Kidney Int. 62 巻頁： 94-105 2002年

二次性副甲状腺機能こう進症に対するｍａｘａｃａｌｃｉｔｏｌ（オキサロール）静注パルス療法の効果　　早期低用量使用の試み査読有り

渡辺緑子, 中田敦博, 八島彰人, 河出恭雅, 佐藤悌, 小杉智規, 鳥山高伸, 川原弘久, 水野正司, 森田良樹, 松尾清一

日本透析医学会雑誌 35 巻 ( 8 ) 頁： 1193 - 1198 2002年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

二次性副甲状腺機能充進症 (II°HPT) が比較的軽度で, 血清intact PTH (i-PTH) が500pg/mL未満の維持血液透析患者に対し, maxacalcitol (オキサロール®注, 中外製薬, 以下OCT) を添付文書上の用法・用量よりも低用量から使用し, その臨床効果を検討した. 対象は経口ビタミンD (VD) 剤を使用しているにもかかわらず, i-PTHが240pg/mL以上500pg/mL未満を示す維持血液透析患者19例 (男性15例, 女性4例) で, i-PTH値よりI群 (11例, 240≦i-PTH<360pg/mL) とII群 (8例, 360≦i-PTH<500pg/mL) に分類した. 経口VD剤を2週間中止した後, OCTを毎回透析終了時にI群では2.5μg, II群では5μgを透析回路静脈側から注入した. OCTの投与量は経過中の血清i-PTHと補正Ca値に応じて増減した. 治療開始前2週から, 開始後48週までを観察期間とし, 血清i-PTH・補正Ca・P・ALP・骨型ALP (b-ALP)・オステオカルシン (BGP)・副甲状腺体積をそれぞれ経時的に測定し, その推移を各群毎に治療開始2週前の値と比較検討した. i-PTHは両群とも, 治療前と比較し有意に低下した. 補正CaはOCT・Ca製剤を用量調節することでコントロール可能であったが, II群でより強い上昇傾向がみられた. P・ALP・b-ALP・BGPは観察期間中両群で有意な変化を認めなかった. 副甲状腺の体積については一部で減少を認めたが, i-PTHとの相関性はみられなかった. 以上のことから, i-PTHが500pg/mL以下の比較的軽度のII°HPTに対する低用量からのOCT静注パルス療法は, 血清Caの上昇を軽度に保ちつつ, 長期的にPTH抑制を維持できることが示唆された.

DOI： 10.4009/jsdt.35.1193

高脂血症を伴う長期維持血液透祈患者におけるポリスルフォン膜（ＰＳ‐ＵＷ）の有用性について査読有り

水野正司, 小林薫, 中田敦博, 渡辺緑子, 鳥山高伸, 川原弘久, 松尾清一

日本透析医学会雑誌 35 巻 ( 1 ) 頁： 43 - 49 2002年

担当区分：筆頭著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本透析医学会

長期血液透析患者において, 心・脳血管障害は合併症の中でも重要な位置を占め, 高脂血症は注目すべき危険因子の一つである. この高脂血症を伴う長期血液透析患者におけるポリスルフォン膜 (PS膜) による脂質代謝の改善効果についての検討, および服用中の高脂血症薬の減量・中止の可能性について検討を行った. 対象は平均透析歴64か月, 食事制限, 服薬コンプライアンスの良好, かつ血中総コレステロール (TC) 値が263±17mg/dLの非糖尿病患者6名 (うち4名はPravastatin sodium (メバロチン®) を内服中) について, 既存のハイパフォーマンス透析膜 (うちCTA膜1例, EVAL膜5例) からPS膜へ変更前, 直後, 1週, 1, 3, 5, 6か月後のそれぞれたついて中2日の透析前に採血を行い血中TC, TG, LDL-C, HDL-C, LDL-TG, HDL-TG, apo-A1, apo-C3等を測定して膜変更前値と比較検討した. 血中のTCはPS膜変更後から下降しはじめ, 3か月後には212±8mg/dLとなり, その後の血中の値に有意な変化はみられなかった. 血中LDL-C, Apo-A1, Apo-C3についても同様に下降した. 対象患者のうち, 高脂血症薬を服用中でかつPS膜に変更6か月後血中TC 180mg/dL以下となった2例について高脂血症薬の減量・中止し, その後の経過をみたところ, 一例は薬剤を中止できこれを継続できた. 他の一例は高脂血症薬中止後再びTCが上昇したため高脂血症薬を再開した. しかし, この症例についてもPS膜へ変更前に比べてTCは有意に抑えられていた. 以上より, 高度の高脂血症を伴う透析患者にPS膜を用いることが脂質代謝改善につながる可能性が示唆され, 内服中の高脂血症薬減量にもつながる可能性が示唆された.

DOI： 10.4009/jsdt.35.43

高脂血症を伴う長期維持血液透析患者におけるポリスルフォン膜(PS-UW)の有用性について査読有り

水野正司, 小林薫, 中田淳博, 渡辺緑子, 鳥山高伸, 川原弘久, 松尾清一

日本透析医学会雑誌 35 巻頁： 43-49 2002年

二次性副甲状腺機能亢進症に対するmaxacalcitorol（オキサロールＲ）静注パルス療法の効果 ―早期低用量使用の試みー査読有り

渡辺緑子, 中田敦博, 八島影人, 河出恭雅, 佐藤悌, 小杉智規, 鳥山高伸, 河原弘久, 水野正司, 森田良樹, 松尾清一

日本透析医学会誌 35 巻頁： 1193-1250 2002年

Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis 査読有り

DS Bardenstein, CJ Cheyer, C Lee, E Cocuzzi, M Mizuno, N Okada, ME Medof

IMMUNOLOGY 104 巻 ( 4 ) 頁： 423 - 430 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL SCIENCE LTD

The open environment of the eye is continuously subject to an influx of foreign agents that can activate complement. Decay-accelerating factor (DAF), membrane cofactor protein (MCP) and CD59 are regulators that protect self-cells from autologous complement activation on their surfaces. They are expressed in the eye at unusually high levels but their physiological importance in this site is unstudied. In the rat, a structural analogue termed 5I2 antigen (5I2 Ag) has actions overlapping DAF and MCP. In this investigation, we injected F(ab')(2) fragments of 5I2 mAb into the conjunctiva and aqueous humor, in the latter case with and without concomitant blockage of CD59. Massive neutrophilic infiltration of the stroma and iris resulted upon blocking 5I2 Ag activity. Frank necrosis of the iris occurred upon concomitant intraocular blockage of CD59. C3b was identified immunohistochemically, and minimal effects were seen in complement-depleted animals and in those treated with non-relevant antibody. The finding that block-age of 5I2 Ag function in periocular tissues and within the eye causes intense conjunctival inflammation and iritis demonstrates the importance of intrinsic complement regulators in protecting ocular tissues from spontaneous or bystander attack by autologous complement.