研究者詳細 - 水野　正司

論文 - 水野　正司

分割表示 350 件中 261 - 280 件目／全件表示 >>

Shiga toxin 1causes direct renal injury in rats 査読有り国際誌 Open Access

Yamamoto ET, Mizuno M, Nishikawa K, Miyazawa S, Zhang LS, Matsuo S, Natori Y

INFECTION AND IMMUNITY 73 巻 ( 11 ) 頁： 7099 - 7106 2005年11月

Novel C5a regulators in inflammatory disease. 招待有り査読有り国際誌

Mizuno M, Cole DS

Expert opinion on investigational drugs 14 巻 ( 7 ) 頁： 807 - 821 2005年7月

Expression of CD46 in developing rat spermatozoa: ultrastructural localisation and utility as a marker of the various stages of the seminiferous tubuli. 査読有り

Mizuno M., Harris CL., Suzuki N., Matsuo S., Morgan BP.

Biol Reprod 72 巻頁： 908-915 2005年

Shiga toxin-1 causes direct renal injury in rats. 査読有り

Yamamoto ET., Mizuno M., Nishikawa K., Miyazawa S., Zhang L., Matsuo S., Natori Y.

Infect Immun 73 巻頁： 7099-7106 2005年

Novel C5a regulators in inflammation. 招待有り査読有り

Mizuno M., Cole DS.

Expert Opin Investig Drugs 14 巻頁： 807-821 2005年

CD59a is the primary regulator of membrane attack complex assembly in the mouse.

Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, Morgan BP

Journal of immunology (Baltimore, Md. : 1950) 173 巻 ( 6 ) 頁： 3684 - 92 2004年9月

Inummohistochemical analysis of membrane complement regulatory proteins in rat testis: unique roles for DAF and MCP in spermatozoal function?

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 41 巻 ( 2-3 ) 頁： 280 - 280 2004年6月

The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. 招待有り査読有り

Mizuno M., Morgan BP.

Current Drug Targets Inflammation & Allergy 3 巻頁： 85-94 2004年

CD59a is the primary regulator of membrane attack complex assembly in the mouse. 査読有り

Baalasubramanian S., Harris CL., Donev RM., Mizuno M., Omidvar N., Song W., Morgan BP.

J. Immunol. 173 巻頁： 3684-3692 2004年

Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. 査読有り

Mizuno M., Harris CL., Johnson PM., Morgan BP.

Biol Reprod 71 巻頁： 1374-1383 2004年

Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. 査読有り

Williams AS., Mizuno M., Richards PJ., Holt DS., Morgan BP

Arthritis Rheum 50 巻頁： 3035-3044 2004年

In two patients on long-term hemodialysis, Etidronate Disodium improved their discomfort and extremities' blood flow associated with severe abnormal arterial wall calcification. 査読有り

Mizuno M., Kashima N., Kato K., Ito A, Matsuo S.

Clin Drug Invest 24 巻頁： 365-371 2004年

Improvement in Discomfort and Decreased Blood Flow Associated with Severe Arterial Wall Calcification following Etidronic Acid. 査読有り国際誌

Mizuno M, Kashima N, Kato K, Ito A, Matsuo S

Clinical drug investigation 24 巻 ( 6 ) 頁： 365 - 71 2004年

Implication of the complement system in the induction of antiglomerular basement membrane glomerulonephritis in WKY rats 査読有り国際誌

SHIKE Tatsuhiko, ISOME Masato, MIZUNO Masashi, SUZUKI Junzo, MATSUO Seiichi, YAMAMOTO Tadashi, SUZUKI Hitoshi

Pathology international 53 巻 ( 11 ) 頁： 757 - 761 2003年11月

Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats.

Shike T, Isome M, Mizuno M, Suzuki J, Matsuo S, Yamamoto T, Suzuki H

Pathology international 53 巻 ( 11 ) 頁： 757 - 61 2003年11月

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids

LIU Man-Chang, MARUYAMA Shoichi, MIZUNO Masashi, MORITA Yoshiki, HANAKI Shigeru, YUZAWA Yukio, MATSUO Seiichi

Clinical and experimental nephrology 7 巻 ( 3 ) 頁： 186 - 194 2003年9月

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. 査読有り国際誌

Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S

Clinical and experimental nephrology 7 巻 ( 3 ) 頁： 186 - 194 2003年9月

Membrane cofactor protein (MCP; CD46) in the rat is expressed only in male germ cells and precursors

Mizuno, M; Harris, CL; Morgan, BP

MOLECULAR IMMUNOLOGY 40 巻 ( 2-4 ) 頁： 202 - 203 2003年9月

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison.

Harris CL, Hanna SM, Mizuno M, Holt DS, Marchbank KJ, Morgan BP

Immunology 109 巻 ( 1 ) 頁： 117 - 26 2003年5月

Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison 査読有り国際共著国際誌

CL Harris, SM Hanna, M Mizuno, DS Holt, KJ Marchbank, BP Morgan

IMMUNOLOGY 109 巻 ( 1 ) 頁： 117 - 126 2003年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING LTD

CD59, the sole membrane regulator of the membrane attack complex of complement, is broadly and abundantly expressed in man and other mammals. In mouse, CD59 is encoded by two homologous genes. The expression patterns and functional roles of the proteins encoded by these genes, mCD59a and mCD59b, have not been well characterized. Here we describe the generation of monoclonal and polyclonal antibodies detecting specifically mCD59a and mCD59b. These reagents have been used to study function and to ascertain the cell and tissue distributions of mCD59a and mCD59b. mCD59a was broadly distributed on endothelia, erythrocytes, platelets, and on numerous other cell types in organs, a distribution pattern resembling that of CD59 in other species. In marked contrast, expression of mCD59b was restricted to germ cell elements in the testis and mature spermatozoa. Both mCD59a and CD59b inhibited human and rodent complement with similar efficiency. These findings demonstrate that the broadly distributed mCD59a is the key regulator of the terminal complement pathway in mice whereas CD59b, expressed only in testis and on sperm, probably plays other roles in vivo.

DOI： 10.1046/j.1365-2567.2003.01628.x

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