研究者詳細 - 水野　正司

論文 - 水野　正司

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Zymosan, but Not Lipopolysaccharide, Triggers Severe and Progressive Peritoneal Injury Accompanied by Complement Activation in a Rat Peritonitis Model 査読有り国際共著国際誌

Mizuno, M; Ito, Y; Hepburn, N; Mizuno, T; Noda, Y; Yuzawa, Y; Harris, CL; Morgan, BP; Matsuo, S

JOURNAL OF IMMUNOLOGY 183 巻 ( 2 ) 頁： 1403 - 1412 2009年7月

Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model. 査読有り

Mizuno M, Ito Y, Hepburn N, Mizuno T, Noda Y, Yuzawa Y, Harris CL, Morgan BP, Matsuo S.

J Immunol 183 巻頁： 1403-1412 2009年

A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage. 査読有り国際共著国際誌

Mizuno, M; Nozaki, M; Morine, N; Suzuki, N; Nishikawa, K; Morgan, BP; Matsuo, S

AMERICAN JOURNAL OF PATHOLOGY 171 巻 ( 2 ) 頁： 402 - 414 2007年8月

High levels of complement C3a receptor in the glomeruli in lupus nephritis 査読有り国際共著国際誌

Mizuno, M; Blanchin, S; Gasque, P; Nishikawa, K; Matsuo, S

AMERICAN JOURNAL OF KIDNEY DISEASES 49 巻 ( 5 ) 頁： 598 - 606 2007年5月

Immunization with autologous CD46 generates a strong autoantibody response in rats that targets spermatozoa 査読有り国際共著国際誌

Mizuno, M; Harris, CL; Morgan, BP

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73 巻 ( 2 ) 頁： 135 - 147 2007年4月

CD55 expression in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa. 査読有り国際共著国際誌

Mizuno M, Donev RM, Harris CL, Morgan BP

Mol. Immunol. 44 巻頁： 1624-1633 2006年

A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis. 招待有り査読有り

Mizuno M

Curr Med Chem 13 巻 ( 14 ) 頁： 1707-1717 - 1717 2006年

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells 査読有り国際共著国際誌

Elward, K; Griffiths, M; Mizuno, M; Harris, CL; Neal, JW; Morgan, BP; Gasque, P

JOURNAL OF BIOLOGICAL CHEMISTRY 280 巻 ( 43 ) 頁： 36342 - 36354 2005年10月

Expression of CD46 in developing rat spermatozoa: Ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli 査読有り国際共著国際誌

Mizuno M, Harris CL, Suzuki N, Matsuo S, Morgan BP

BIOLOGY OF REPRODUCTION 72 巻 ( 4 ) 頁： 908 - 915 2005年4月

Nucleic acids and CD46 are key regulators in innate immune recognition and the finely tuned removal of “danger-self". 査読有り

Elward K, Griffiths M., Mizuno M., Harris CL., Neal JW., Morgan BP., Gasque P.

J Biol Chem 280 巻頁： 36342-36354 2005年

Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3 査読有り国際共著国際誌

Mizuno, M; Harris, CL; Johnson, PM; Morgan, BP

BIOLOGY OF REPRODUCTION 71 巻 ( 4 ) 頁： 1374 - 1383 2004年10月

Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis 査読有り国際共著国際誌

AS Williams, M Mizuno, PJ Richards, DS Holt, BP Morgan

ARTHRITIS AND RHEUMATISM 50 巻 ( 9 ) 頁： 3035 - 3044 2004年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Objective. To investigate the roles of CD59a in the protection of joint tissue in the context of murine antigen-induced arthritis (AIA).
Methods. AIA was triggered in CD59a-deficient (CD59a(-/-)) mice and in CD59a-sufficient (CD59a(+/+)) controls; the course and severity of disease were compared between groups. The effects on arthritis of restoring CD59 to the joint in CD59a(-/-) mice by use of a membrane-targeted recombinant CD59 were also explored.
Results. Disease, as assessed clinically by measurement of joint swelling on day I (P < 0.0001), day 2 (P < 0.01), and day 7 (P < 0.02) and histologically from indicators of joint damage on day 21 (P < 0.02), was significantly enhanced in CD59a(-/-) mice compared with CD59a(+/+) wild-type controls. Membrane attack complex (MAC) deposition in the arthritic joints of CD59a(-/-) mice was also increased compared with that in the joints of CD59a(+/+) controls. Restitution of CD59 activity in joints of CD59a(-/-) mice was attempted with soluble recombinant rat CD59 (sCD59) or with a novel membrane-targeted rat CD59 derivative (sCD59APT542). Strong immunohistochemical staining of the synovial membrane and subsynovial tissue was apparent in sCD59-APT542-injected joints, but not in joints injected with untargeted sCD59. Intraarticular administration of sCD59-APT542 markedly ameliorated disease severity in CD59a(-/-) mice, knee swelling was significantly reduced over the time course of the disease, and joint damage, assessed histologically, was significantly milder on day 21 (P < 0.05).
Conclusion. These data firmly implicate the MAC of complement as a major effector of joint damage in the murine AIA model of rheumatoid arthritis (RA), and they provide a rationale for the inhibition of MAC assembly as a therapeutic strategy for RA.

DOI： 10.1002/art.20478

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CD59a is the primary regulator of membrane attack complex assembly in the mouse 査読有り国際共著国際誌

S Baalasubramanian, CL Harris, RM Donev, M Mizuno, N Omidvar, WC Song, BP Morgan

JOURNAL OF IMMUNOLOGY 173 巻 ( 6 ) 頁： 3684 - 3692 2004年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER ASSOC IMMUNOLOGISTS

Gene-deleted mice have provided a potent tool in efforts to understand the roles of complement and complement-regulating proteins in vivo. In particular, mice deficient in the membrane regulators complement receptor 1-related gene/protein y, decay-accelerating factor, or CD59 have demonstrated homeostatic relevance and backcrossing between the strains has revealed cooperativity in regulation. In mouse, genes encoding decay-accelerating factor and CD59 have been duplicated and show differential expression in tissues, complicating interpretation and extrapolation of findings to man. The first described form of CD59, CD59a, is broadly distributed and deletion of the cd59a gene causes a mild hemolytic phenotype with increased susceptibility in complement-mediated disease models. The distribution of the second form, CD59b, was originally described as testis specific, but later by some as widespread. Deletion of the cd59b gene caused a severe hemolytic and thrombotic phenotype. To apply data from these mouse models to man it is essential to know the relative distribution and functional roles of these two forms of CD59. We have generated new specific reagents and used them in sensitive quantitative analyses to comprehensively characterize expression of mRNA and protein and functional roles of CD59a and CD59b in wild-type (wt) and CD59a-negative mice. cd59b mRNA was detected only in testis and, at very low levels, in bone marrow. CD59b protein was present on mature spermatozoa and precursors and, in trace amounts, erythrocytes. Erythrocyte CD59b did not inhibit complement lysis except when CD59a was absent or blocked. These data confirm that CD59a is the primary regulator of complement membrane attack in mouse.

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The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. 招待有り査読有り国際共著国際誌

Mizuno M, Morgan BP

Current Drug Targets Inflammation & Allergy 3 巻頁： 85-94 2004年

Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. 査読有り国際共著国際誌

Fraser DA, Harris CL, Williams AS, Mizuno M, Gallagher S, Smith RA, Morgan BP

The Journal of biological chemistry 278 巻 ( 49 ) 頁： 48921 - 48927 2003年12月

Generation of a recombinant, membrane-targeted form of the complement regulator, CD59: activity in vitro and in vivo. 査読有り

Fraser DA., Harris CL., Williams AS., Mizuno M., Gallagher S., Smith RAG., Morgan BP.

J. Biol. Chem. 278 巻頁： 48921-48927 2003年

Membrane complement regulators protect against the development of type II collagen-induced arthritis in rats 査読有り国際共著国際誌

Mizuno, M; Nishikawa, K; Spiller, OB; Morgan, BP; Okada, N; Okada, H; Matsuo, S

ARTHRITIS AND RHEUMATISM 44 巻 ( 10 ) 頁： 2425 - 2434 2001年10月

CD59 protects rat kidney from complement mediated injury in collaboration with Crry 査読有り国際共著国際誌

Watanabe M, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Morgan BP, Okada N, Okada H, Matsuo S

KIDNEY INTERNATIONAL 58 巻 ( 4 ) 頁： 1569 - 1579 2000年10月

Acute renal failure after a sea anemone sting 査読有り国際誌

Mizuno, M; Nishikawa, K; Yuzawa, Y; Kanie, T; Mori, H; Araki, Y; Hotta, N; Matsuo, S

AMERICAN JOURNAL OF KIDNEY DISEASES 36 巻 ( 2 ) 頁： art. no. - E10 2000年8月

Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced by anti-rat CD59 antibody. 査読有り国際共著

Mizuno M, Nishikawa K, Morgan B.P, Matsuo S

Clin. Exp. Immunol. 119 巻頁： 368-375 2000年

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