研究者詳細 - 阿部　洋

論文 - 阿部　洋

分割表示 248 件中 41 - 60 件目／全件表示 >>

Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units 査読有り

Shu Zhaoma, Ota Azumi, Takayama Yukiya, Katsurada Yuri, Kusamori Kosuke, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Tada Seiichi, Ito Yoshihiro, Nishikawa Makiya, Kimura Yasuaki, Abe Hiroshi

CHEMICAL & PHARMACEUTICAL BULLETIN 68 巻 ( 2 ) 頁： 129 - 132 2020年2月

Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors 査読有り

Kimura Yasuaki, Shu Zhaoma, Ito Mika, Abe Naoko, Nakamoto Kosuke, Tomoike Fumiaki, Shuto Satoshi, Ito Yoshihiro, Abe Hiroshi

CHEMICAL COMMUNICATIONS 56 巻 ( 3 ) 頁： 466 - 469 2020年1月

SYNTHESIS AND BIOLOGICAL EVALUATION OF NMDI14 DERIVATIVES AS ANTI-MESOTHELIOMA AGENTS 査読有り

Hong Nhung Nguyen, Suzuki Koya, Kimura Yasuaki, Hirokawa Takatsugu, Murakami-Tonami Yuko, Abe Hiroshi

Heterocycles 100 巻 ( 2 ) 頁： 253 - 266 2020年1月

Intracellular delivery of Antisense DNA and siRNA with amino groups masked with disulfide units 査読有り

Zhaoma Shu, Azumi Ota, Yukiya Takayama, Yuri Katsurada, Kosuke Kusamori, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Makiya Nishikawa, Yasuaki Kimura, Hiroshi Abe

Chemical and Pharmaceutical Bulletins 2020年

Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors 査読有り

Yasuaki Kimura, Zhaoma Shu, Mika Ito, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe

Chemical Communications 2020年

Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes 査読有り国際誌

Hirotaka Fujita, Ryota Oikawa, Mayu Hayakawa, Fumiaki Tomoike, Yasuaki Kimura, Hiroyuki Okuno, Yoshiki Hatashita, Carolina Fiallos Oliveros, Haruhiko Bito, Toshio Ohshima, Satoshi Tsuneda, Hiroshi Abe, Takafumi Inoue

Journal of Biological Chemistry in press 巻 2020年

Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units. 査読有り

68 巻 ( 2 ) 頁： 129 - 132 2020年

Synthesis of 1,1,2-trisubstituted cyclopropane nucleosides in enantiomerically pure forms 査読有り国際誌

Fushihara Daichi, Fukuda Hayato, Abe Hiroshi, Shuto Satoshi

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 38 巻 ( 12 ) 頁： 921 - 941 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nucleosides, Nucleotides and Nucleic Acids

Due to the unique rigid and small steric feature of cyclopropane, cyclopropane nucleosides (CPNs) in which the ribose (deoxyribose) of nucleosides are replaced by a hydroxy-substituted cyclopropane, are of great biological interest. Novel 1,1,2-trisubstituted cyclopropane nucleosides were synthesized in enantiomerically pure forms as potential antiviral agents. In the synthesis, two cyclopropane tosylates, which were prepared from chiral cyclopropane lactones previously reported by us, were used effectively as common intermediates for the CPNs. These CPNs are also potentially useful as nucleoside units to incorporate into oligonucleotides in nucleic acids chemotherapy studies.

DOI： 10.1080/15257770.2019.1625380

N-6-methyl adenosine in siRNA evades immune response without reducing RNAi activity 査読有り

Imaeda Akihiro, Tomoike Fumiaki, Hayakawa Mayu, Nakamoto Kosuke, Kimura Yasuaki, Abe Naoko, Abe Hiroshi

38 巻 ( 12 ) 頁： 972 - 979 2019年12月

Translational contro by secondary-structure formation in mRNA in eukaryotic system 査読有り

Daisuke Kawaguchi, Saaya Shimizu, Naoko Abe, Fumitaka Hashiya, Tomoike Fumiaki, Yasuaki Kimura, Hiroshi Abe

Nucleosides, Nucleotides and Nucleic Acids 頁： 1 - 9 2019年9月

RNA imaging by chemical probes 招待有り査読有り

Tomoike Fumiaki, Abe Hiroshi

ADVANCED DRUG DELIVERY REVIEWS 147 巻頁： 44 - 58 2019年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Advanced Drug Delivery Reviews

Sequence-specific detection of intracellular RNA is one of the most important approaches to understand life phenomena. However, it is difficult to detect RNA in living cells because of its variety and scarcity. In the last three decades, several chemical probes have been developed for RNA detection in living cells. These probes are composed of DNA or artificial nucleic acid and hybridize with the target RNA in a sequence-specific manner. This hybridization triggers a change of fluorescence or a chemical reaction. In this review, we classify the probes according to the associated fluorogenic mechanism, that is, interaction between fluorophore and quencher, environmental change of fluorophore, and template reaction with/without ligation. In addition, we introduce examples of RNA imaging in living cells.

DOI： 10.1016/j.addr.2019.08.001

Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA 査読有り

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 巻 ( 20 ) 頁： 6611 - 6615 2019年5月

Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA 査読有り

Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

Angewandte Chemie 131 巻 ( 20 ) 頁： 6683 2019年5月

A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP(1-1)) in Human Cells 査読有り

Shishido Yuko, Tomoike Fumiaki, Kuwata Keiko, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, Abe Naoko, Kimura Yasuaki, Shuto Satoshi, Abe Hiroshi

CHEMBIOCHEM 20 巻 ( 7 ) 頁： 900 - 905 2019年4月

膜透過性を有するGST共有結合性阻害剤の開発

友池史明, 宍戸裕子, 藤川遥加, 木村康明, 桑田啓子, 村上優子, 福井健二, 関戸好孝, 矢野貴人, 亀田倫史, 周東智, 阿部洋

日本薬学会年会要旨集 139年会巻 ( 2 ) 頁： 80 - 80 2019年3月

ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発査読有り

福井竜介, 新美結士, 片倉秀雄, 鈴木哲郎, 村上努, 児玉栄一, 木村康明, 阿部洋

日本薬学会年会要旨集 139年会巻 ( 2 ) 頁： 103 - 103 2019年3月

Disulfide‐unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA 査読有り

Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe

Angewandte Chemie International Edition 58 巻頁： 6611 - 6615 2019年

A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells 査読有り

Yuko Shishido, Fumiaki Tomoike, Keiko Kuwata, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Naoko Abe, Yasuaki Kimura, Satoshi Shuto, Hiroshi Abe

ChemBioChem 20 巻頁： 900 - 905 2019年

N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity 査読有り

Akihiro Imaeda, Fumiaki Tomoike, Mayu Hayakawa, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Hiroshi Abe

Nucleosides, Nucleotides and Nucleic Acids 38 巻頁： 6611 - 6615 2019年

Nearest-neighbor parameter for inosine-cytosine pairs through a combined experimental and computational approach 査読有り

Shun Sakuraba, Junichi Iwakiri, Michiaki Hamada, Tomoshi Kameda, Genichiro Tsuji, Yasuaki Kimura, Hiroshi Abe, Kiyoshi Asai

2018年10月

　前のページ - 次のページ　

<阿部 洋>

論文 - 阿部 洋

<阿部　洋>

論文 - 阿部　洋