論文 - 山中 宏二
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Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. 査読有り
Furukawa Y, Kaneko K, Yamanaka K, Nukina N
J. Biol. Chem. 285 巻 頁： 22221-22231 2010年
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Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS. 査読有り
Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Clevalend DW
Neuron 67 巻 頁： 575-587 2010年
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Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. 査読有り
Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW
Proc. Natl. Acad. Sci., USA. 106 巻 頁： 4465-4470 2009年
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Gigaxonin controls vimentin organization through tubulin chaperone-independent pathway. 査読有り
Cleveland DW, Yamanaka K, Bomont P
Hum. Mol. Genet. 18 巻 頁： 1384-1394 2009年
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Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. 査読有り
Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW
Proc. Natl. Acad. Sci., USA. 105 巻 頁： 12599-12604 2008年
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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. 査読有り
Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW
Nat. Neurosci. 11 巻 頁： 251-253 2008年
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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. 査読有り
Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LSB
Proc. Natl. Acad. Sci., USA. 105 巻 頁： 7594-7599 2008年
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Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. 査読有り
Furukawa Y, Kaneko K, Yamanaka K, O'Halloran, TV, Nukina N
J. Biol. Chem. 283 巻 頁： 24167-24176 2008年
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Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS. 査読有り
Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S
J. Neurochem. 102 巻 頁： 1497-1505 2007年
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Onset and Progression in Inherited ALS determined by Motor Neurons and Microglia. 査読有り
Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW
Science 312 巻 頁： 1389-1392 2006年
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Novel Missense Mutation in ALS2 gene results in Infantile Ascending Hereditary Spastic Paralysis. 査読有り
Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O
Ann. Neurol. 59 巻 頁： 976-980 2006年
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Progressive axonal degeneration and slowness in ALS2-deficient mice. 査読有り
Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW
Ann. Neurol. 60 巻 頁： 95-104 2006年
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Antisense Oligonucleotides as a Therapy for Neurodegenerative diseases. 査読有り
Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW
J. Clin. Invest. 116 巻 頁： 2290-2296 2006年
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Gene transfer demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial amyotrophic lateral sclerosis. 査読有り
Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK
Proc. Natl. Acad. Sci. USA 103 巻 頁： 19546-19551 2006年
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Virus-delivered siRNA preserves strength in ALS mice. 査読有り
Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW
Ann. Neurol. 57 巻 頁： 773-776 2005年
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Cleveland DW: Determinants of rapid disease progression in ALS. 査読有り
Yamanaka K
Neurology 65 巻 頁： 1859-1860 2005年
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ALS2-Related Disorders. 査読有り
Bertini E, Eymard-Pierre E, Boespflug-Tanguy O, Cleveland DW, Yamanaka K
GeneReviews at GeneTests: Medical Genetics Information Resource. 頁： 00 2005年
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Unstable mutants in the peripheral endosomal membrane component ALS2 cause early onset motor neuron disease. 査読有り
Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW
Proc. Natl. Acad. Sci. USA 100 巻 頁： 16041-16046 2003年
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Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. 査読有り
Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K
Nat. Cell Biol. 5 巻 頁： 336-340 2003年
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NEDD8 recruits E2-ubiquitin to SCF E3 ligase. 査読有り
Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, Minato N, Suzuki H, Shimbara N, Hidaka Y, Osaka F, Omata M, Tanaka K
EMBO J. 20 巻 頁： 4003-4012 2001年