研究者詳細 - 山中　宏二

論文 - 山中　宏二

分割表示 >> ／全件表示 107 件中 1 - 107 件目

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice 査読有り

Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 12 巻 ( 1 ) 頁： 184 2024年11月

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation 査読有り

Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K

CELL DEATH & DISEASE 15 巻 ( 11 ) 頁： 858 2024年11月

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease 査読有り Open Access

Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K

JOURNAL OF NEUROINFLAMMATION 21 巻 ( 1 ) 頁： 55 2024年2月

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice 査読有り Open Access

Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K

ISCIENCE 27 巻 ( 2 ) 頁： 108872 2024年2月

Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS 査読有り

Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 巻 ( 47 ) 頁： e2315347120 2023年11月

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis 査読有り

Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K

SCIENCE ADVANCES 9 巻 ( 31 ) 頁： eadf6895 2023年8月

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation 査読有り

Hashimoto, K; Watanabe, S; Akutsu, M; Muraki, N; Kamishina, H; Furukawa, Y; Yamanaka, K

JOURNAL OF BIOLOGICAL CHEMISTRY 229 巻 ( 6 ) 頁： 104798 2023年6月

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis 査読有り

Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K

NEUROBIOLOGY OF DISEASE 179 巻頁： 106031 2023年4月

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis 査読有り

Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K

FASEB JOURNAL 35 巻 ( 7 ) 頁： e21688 2021年7月

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease 査読有り

Sobue, A; Komine, O; Hara, Y; Endo, F; Mizoguchi, H; Watanabe, S; Murayama, S; Saito, T; Saido, TC; Sahara, N; Higuchi, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 9 巻 ( 1 ) 頁： 1 2021年1月

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43 査読有り

Watanabe, S; Inami, H; Oiwa, K; Murata, Y; Sakai, S; Komine, O; Sobue, A; Iguchi, Y; Katsuno, M; Yamanaka, K

CELL DEATH & DISEASE 11 巻 ( 10 ) 頁： 909 2020年10月

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS 招待有り査読有り国際共著

Watanabe S, Ilieva Hristelina, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K

EMBO Molecular Medicine 8 巻 ( 12 ) 頁： 1421-1437 2016年11月

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells 査読有り国際共著

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

11 巻 ( 4 ) 頁： 592-604 2015年4月

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. 査読有り Open Access

Maetani Y, Kurashige T, Tada Y, Kume K, Watanabe T, Sotomaru Y, Yamanaka K, Maruyama H, Kawakami H

Neuroscience research 216 巻頁： 104893 2025年7月

Correction: Long-term systemic androgen deprivation partially modulates neuroinflammation in male App(NL-G-F/NL-G-F) mice. Open Access

Maekawa K, Sobue A, Komine O, Saito Y, Murayama S, Saido TC, Saito T, Yamanaka K

Scientific reports 15 巻 ( 1 ) 頁： 19666 2025年6月

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases.

Watanabe S, Yamanaka K

BioEssays : news and reviews in molecular, cellular and developmental biology 頁： e70016 2025年5月

Long-term systemic androgen deprivation partially modulates neuroinflammation in male App(NL-G-F/NL-G-F) mice. Open Access

Maekawa K, Sobue A, Komine O, Saito Y, Murayama S, Saido TC, Saito T, Yamanaka K

Scientific reports 15 巻 ( 1 ) 頁： 14702 2025年4月

Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. 査読有り

Fuma K, Iitani Y, Imai K, Ushida T, Tano S, Yoshida K, Yokoi A, Miki R, Kidokoro H, Sato Y, Hara Y, Ogi T, Nomaki K, Tsuda M, Komine O, Yamanaka K, Kajiyama H, Kotani T

Communications biology 8 巻 ( 1 ) 頁： 75 2025年1月

A preliminary study on the effects of long-term robot suit exercise training on gait function and quality of life in patients with spinal and bulbar muscular atrophy 査読有り

Hirayama, T; Morioka, H; Sugisawa, T; Shibukawa, M; Ebina, J; Hanashiro, S; Nagasawa, J; Yanagihashi, M; Okuni, I; Nakajima, T; Murakami, Y; Yamanaka, K; Ebihara, S; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE 128 巻頁： 110778 2024年10月

Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia 査読有り

Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y

FREE RADICAL BIOLOGY AND MEDICINE 223 巻頁： 458 - 472 2024年10月

Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes 査読有り

Leventoux, N; Morimoto, S; Ishikawa, M; Nakamura, S; Ozawa, F; Kobayashi, R; Watanabe, H; Supakul, S; Okamoto, S; Zhou, Z; Kobayashi, H; Kato, C; Hirokawa, Y; Aiba, I; Takahashi, S; Shibata, S; Takao, M; Yoshida, M; Endo, F; Yamanaka, K; Kokubo, Y; Okano, H

ACTA NEUROPATHOLOGICA 147 巻 ( 1 ) 頁： 84 2024年6月

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement 査読有り国際共著 Open Access

Watanabe, S; Amporndanai, K; Awais, R; Latham, C; Awais, M; O'Neill, PM; Yamanaka, K; Hasnain, SS

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 12118 2024年5月

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities 招待有り査読有り

Kawade, N; Yamanaka, K

FEBS OPEN BIO 14 巻 ( 2 ) 頁： 194 - 216 2024年2月

An open chat with… Koji Yamanaka

Tsagakis, I; Yamanaka, K

FEBS OPEN BIO 14 巻 ( 2 ) 頁： 162 - 164 2024年2月

Depletion of perivascular macrophages delays ALS disease progression by ameliorating blood-spinal cord barrier impairment in SOD1G93A mice 査読有り

Adachi, K; Miyata, K; Chida, Y; Hirose, M; Morisaki, Y; Yamanaka, K; Misawa, H

FRONTIERS IN CELLULAR NEUROSCIENCE 17 巻頁： 1291673 2023年11月

Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis 査読有り

Hirayama, T; Shibukawa, M; Yanagihashi, M; Warita, H; Atsuta, N; Yamanaka, K; Kano, O

ACTA NEUROLOGICA BELGICA 123 巻 ( 5 ) 頁： 1797 - 1804 2023年10月

The necessity to improve disaster preparedness among patients with amyotrophic lateral sclerosis and their families 査読有り

Hirayama, T; Shibukawa, M; Morioka, H; Hozumi, M; Tsuda, H; Atsuta, N; Izumi, Y; Nakayama, Y; Shimizu, T; Inoue, H; Urushitani, M; Yamanaka, K; Aoki, M; Ebihara, S; Takeda, A; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE 116 巻頁： 87 - 92 2023年10月

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype 査読有り

Matsudaira, T; Nakano, S; Konishi, Y; Kawamoto, S; Uemura, K; Kondo, T; Sakurai, K; Ozawa, T; Hikida, T; Komine, O; Yamanaka, K; Fujita, Y; Yamashita, T; Matsumoto, T; Hara, E

COMMUNICATIONS BIOLOGY 6 巻 ( 1 ) 頁： 665 2023年6月

Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease

Sobue, A; Komine, O; Yamanaka, K

INFLAMMATION AND REGENERATION 43 巻 ( 1 ) 頁： 26 2023年5月

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease (Volume-17, page-1, year-2023)

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE 17 巻頁： 1160444 2023年3月

Role of sex hormones in neuroinflammation in Alzheimer's disease. 招待有り査読有り

Maekawa K, Yamanaka K.

Clinical and Experimental Neuroimmunology 14 巻 2023年2月

Neuroinflammation in neurodegenerative disease 招待有り査読有り

Yamanaka, K

NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 1 ) 頁： 30 - 32 2023年2月

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease 査読有り

Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K

FRONTIERS IN CELLULAR NEUROSCIENCE 16 巻頁： 1045647 2023年1月

Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS 査読有り

Hirose, M; Asano, M; Watanabe-Matsumoto, S; Yamanaka, K; Abe, Y; Yasui, M; Tokuda, E; Furukawa, Y; Misawa, H

NEUROSCIENCE RESEARCH 171 巻頁： 74 - 82 2021年10月

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction 査読有り

Konishi, H; Okamoto, T; Hara, Y; Komine, O; Tamada, H; Maeda, M; Osako, F; Kobayashi, M; Nishiyama, A; Kataoka, Y; Takai, T; Udagawa, N; Jung, SF; Ozato, K; Tamura, T; Tsuda, M; Yamanaka, K; Ogi, T; Sato, K; Kiyama, H

EMBO JOURNAL 39 巻 ( 22 ) 頁： e104464 2020年11月

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease 査読有り

Saifullah, MAB; Komine, O; Dong, YT; Fukumoto, K; Sobue, A; Endo, F; Saito, T; Saido, TC; Yamanaka, K; Mizoguchi, H

MOLECULAR BRAIN 13 巻 ( 1 ) 頁： 147 2020年11月

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis 査読有り国際共著

Amporndanai, K; Rogers, M; Watanabe, S; Yamanaka, K; O'Neill, PM; Hasnain, SS

EBIOMEDICINE 59 巻頁： 102980 2020年9月

The regulation of glucose metabolism by astrocytes in diet induced obesity mice

Sugiyama, M; Banno, R; Sun, R; Yaginuma, H; Taki, K; Takagi, H; Ito, Y; Yamanaka, K; Arima, H

DIABETOLOGIA 63 巻 ( SUPPL 1 ) 頁： S266 - S266 2020年9月

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions 査読有り

Sugiyama, M; Banno, R; Yaginuma, H; Taki, K; Mizoguchi, A; Tsunekawa, T; Onoue, T; Takagi, H; Ito, Y; Iwama, S; Goto, M; Suga, H; Komine, O; Yamanaka, K; Arima, H

NEUROCHEMISTRY INTERNATIONAL 136 巻頁： 104733 2020年6月

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair 査読有り国際共著

Nakazawa, Y; Hara, Y; Oka, Y; Komine, O; van den Heuvel, D; Guo, CW; Daigaku, Y; Isono, M; He, YX; Shimada, M; Kato, K; Jia, N; Hashimoto, S; Kotani, Y; Miyoshi, Y; Tanaka, M; Sobue, A; Mitsutake, N; Suganami, T; Masuda, A; Ohno, K; Nakada, S; Mashimo, T; Yamanaka, K; Luijsterburg, MS; Ogi, T

CELL 180 巻 ( 6 ) 頁： 1228 - + 2020年3月

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration. 査読有り

Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K

Molecular brain 13 巻 ( 1 ) 頁： 8 2020年1月

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. 査読有り国際共著

Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K

Acta neuropathologica communications 7 巻 ( 1 ) 頁： 118 2019年7月

Phenotypic heterogeneity of astrocytes in motor neuron disease. 招待有り査読有り国際共著

Trias E, Barbeito L, Yamanaka K

Clinical & experimental neuroimmunology 9 巻 ( 4 ) 頁： 225 - 234 2018年11月

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis 査読有り

Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H

Neuroscience Research 133 巻頁： 48-57 2018年8月

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda Eiichi, Nomura Takao, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1864 巻 ( 6 ) 頁： 2119 - 2130 2018年6月

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice 査読有り

Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K

Journal of Neurochemistry 145 巻 ( 1 ) 頁： 80-89 2018年4月

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. 査読有り

Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K

Cell Death and Differentiation 25 巻 ( 12 ) 頁： 2130-2146 2018年3月

The Multi-dimensional roles of astrocytes in ALS. 招待有り査読有り

Yamanaka K, Komine O

Neuroscience Research 126 巻頁： 31 - 38 2018年1月

TDP-43 accelerates age-dependent degeneration of interneurons 査読有り

Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K

Scientific Reports 7 巻頁： 14972 2017年11月

Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS

Endo, F; Kurita, T; Yamanaka, K

JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻頁： 203 - 204 2017年10月

Collapse of mitochondria-associated membrane as common pathomechanism for amyotrophic lateral sclerosis

Watanabe, S; Ilieva, H; Tamada, H; Nomura, H; Komine, O; Endo, F; Jin, S; Mancias, P; Kiyama, H; Yamanaka, K

JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻頁： 104 - 104 2017年10月

Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction

Nishino K, Watanabe S, Komine O, Yamanaka K.

Journal of the Neurological Sciences 381 巻頁： 570 2017年10月

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. 査読有り

Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H

Scientific Reports 7 巻頁： 7348 2017年8月

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis. 査読有り

Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y.

Protein Sci 26 巻 ( 3 ) 頁： 484-496 2017年3月

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai Itsuki, Tokuda Eiichi, Mukaiyama Atsushi, Akiyama Shuji, Endo Fumito, Yamanaka Koji, Misawa Hidemi, Furukawa Yoshiaki

PROTEIN SCIENCE 26 巻 ( 3 ) 頁： 484 - 496 2017年3月

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. 査読有り

Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.

Molecular Neurodegeneration 12 巻頁： 2 2017年1月

Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis

Tokuda Eiichi, Anzai Itsuki, Nomura Takao, Toichi Keisuke, Watanabe Masahiko, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

MOLECULAR NEURODEGENERATION 12 巻 ( 1 ) 頁： 2 2017年1月

Proteasomal dysfunction induced by diclofenac engenders apoptosis through mitochondrial pathway

Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A

J. Cell. Biochem. 2016年8月

Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 査読有り

Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.

Scientific Reports 6 巻頁： 27354 2016年6月

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. 査読有り

Lasiene J, Komine O, Fujimori-Tonou. N, Powers B, Endo F, Watanabe S, Shjie J, Ravits J, Horner P, Misawa H, Yamanaka K

Acta Neuropathologica Communications 18 巻 ( 4 ) 2016年2月

Neuroinflammation in motor neuron disease.

Komine O, Yamanaka K

Nagoya Journal of Medical Science 77 巻 ( 4 ) 頁： 537-549 2015年11月

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. 査読有り国際共著

Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A

Neurobiology of Disease 86 巻頁： 16-28 2015年11月

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. 査読有り

Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K

Cell Death and Disease 5 巻頁： e1497 2014年10月

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. 査読有り

Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K

Molecular Brain 7 巻 ( 62 ) 2014年8月

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. 査読有り

Austin James J., Wright Gareth S., Watanabe S, Grossman G, Antonyuk S V., Yamanaka K, Hasnan S. S

Proceedings of the National Academy of Sciences of the United States of America 111 巻 ( 11 ) 頁： 4309-4314 2014年3月

Case of familial amyotrophic lateral sclerosis showing gadolinium-enhanced cranial nerves on magnetic resonance imaging associated with rapid progression of facial nerve palsy 査読有り

Mizuno M, Ueki Y, Sakurai K, Okita K, Endo F, Yamanaka K, Morita M, Matsukawa N

Neurology and Clinical Neuroscience 頁： -- 2014年2月

Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis 査読有り

Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y

Journal of Biological Chemistry 289 巻 ( 2 ) 頁： 1192-1202 2014年1月

Animal models for neurodegenerative disorders

Tsuiji H, Yamanaka K

Animal Biotechnology 頁： 39-56 2013年12月

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis 査読有り

Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N

FEBS Letters 587 巻 ( 16 ) 頁： 2500-2505 2013年8月

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 査読有り

Mishra Amit K, Maheshiwari M, Chhangani D, Fujimori-T N, Endo F, Joshi Ajai P, Jana Nihar R, Yamanaka K

Neurobiology of Aging 34 巻 ( 4 ) 頁： 1310.e11-23 2013年4月

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. 査読有り

Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka , Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki Shoichi, Tanaka F, Sobue G

Brain 136 巻 ( 5 ) 頁： 1371-1382 2013年2月

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. 査読有り

Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K

EMBO Molecular Medicine 5 巻 ( 2 ) 頁： 221-234 2013年2月

Deletion of TLR-Associted signaling adaptor TRIF significantly accelerates disease progression of ALS mice. 査読有り

Komine O, Fujimori-Tonou N, Yamashita H, Moriwaki Y, Misawa H, Yamanaka K

61 巻頁： S75-S76 2013年

The role of microglia-immune interaction in neurodegeneration of ALS mouse model.

Yamanaka K

Journal of Neurochemistry 125 巻頁： 89 2013年

Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked TDP-43 mutations. 査読有り

Watanabe S, Kaneko K, Yamanaka K

J Biol Chem 288 巻頁： 3641-3654 2012年12月

Disulfide scrambling describes the oligomer formation of SOD1 proteins in the familial form of ALS. 査読有り

Toichi K, Yamanaka K, Furukawa Y

J Biol Chem 288 巻頁： 4970-1980 2012年12月

E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 査読有り

Mishra A, Maheshwari M, Chhangani D, Fujimori-Tonou N, Endo, F, Joshi AP, Jana NR, Yamanaka K

Neurobiol Aging 34 巻 ( 1310 ) 頁： e11-23 2012年10月

A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble TAR DNA binding protein-43 inclusions. 査読有り

Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N

J. Biol. Chem 286 巻頁： 18664-18672 2011年

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's 査読有り

Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A

PLoS One 6 巻 ( 6 ) 頁： e21108 2011年

Glial cells in Amyotrophic Lateral Sclerosis. 査読有り

Lasiene J, Yamanaka K

Neurol Res Int 頁： 718987 2011年

Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. 査読有り

Furukawa Y, Kaneko K, Yamanaka K, Nukina N

J. Biol. Chem. 285 巻頁： 22221-22231 2010年

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS. 査読有り

Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Clevalend DW

Neuron 67 巻頁： 575-587 2010年

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. 査読有り

Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW

Proc. Natl. Acad. Sci., USA. 106 巻頁： 4465-4470 2009年

Gigaxonin controls vimentin organization through tubulin chaperone-independent pathway. 査読有り

Cleveland DW, Yamanaka K, Bomont P

Hum. Mol. Genet. 18 巻頁： 1384-1394 2009年

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. 査読有り

Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW

Proc. Natl. Acad. Sci., USA. 105 巻頁： 12599-12604 2008年

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. 査読有り

Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW

Nat. Neurosci. 11 巻頁： 251-253 2008年

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. 査読有り

Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LSB

Proc. Natl. Acad. Sci., USA. 105 巻頁： 7594-7599 2008年

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. 査読有り

Furukawa Y, Kaneko K, Yamanaka K, O'Halloran, TV, Nukina N

J. Biol. Chem. 283 巻頁： 24167-24176 2008年

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS. 査読有り

Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S

J. Neurochem. 102 巻頁： 1497-1505 2007年

Onset and Progression in Inherited ALS determined by Motor Neurons and Microglia. 査読有り

Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW

Science 312 巻頁： 1389-1392 2006年

Novel Missense Mutation in ALS2 gene results in Infantile Ascending Hereditary Spastic Paralysis. 査読有り

Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O

Ann. Neurol. 59 巻頁： 976-980 2006年

Progressive axonal degeneration and slowness in ALS2-deficient mice. 査読有り

Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW

Ann. Neurol. 60 巻頁： 95-104 2006年

Antisense Oligonucleotides as a Therapy for Neurodegenerative diseases. 査読有り

Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW

J. Clin. Invest. 116 巻頁： 2290-2296 2006年

Gene transfer demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial amyotrophic lateral sclerosis. 査読有り

Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK

Proc. Natl. Acad. Sci. USA 103 巻頁： 19546-19551 2006年

Virus-delivered siRNA preserves strength in ALS mice. 査読有り

Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW

Ann. Neurol. 57 巻頁： 773-776 2005年

Cleveland DW: Determinants of rapid disease progression in ALS. 査読有り

Yamanaka K

Neurology 65 巻頁： 1859-1860 2005年

ALS2-Related Disorders. 査読有り

Bertini E, Eymard-Pierre E, Boespflug-Tanguy O, Cleveland DW, Yamanaka K

GeneReviews at GeneTests: Medical Genetics Information Resource. 頁： 00 2005年

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early onset motor neuron disease. 査読有り

Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW

Proc. Natl. Acad. Sci. USA 100 巻頁： 16041-16046 2003年

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. 査読有り

Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K

Nat. Cell Biol. 5 巻頁： 336-340 2003年

NEDD8 recruits E2-ubiquitin to SCF E3 ligase. 査読有り

Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, Minato N, Suzuki H, Shimbara N, Hidaka Y, Osaka F, Omata M, Tanaka K

EMBO J. 20 巻頁： 4003-4012 2001年

Multiple thymoma with myotonic dystrophy. 査読有り

Hirai T, Yamanaka A, Fujimoto T, Takahashi A, Takayama Y, Yamanaka K

Japanese Journal Thoracic Cardiovascular Surgery 49 巻頁： 457-460 2001年

Stabilization of iron regulatory protein 2, IRP2, by aluminum. 査読有り

Yamanaka K, Minato N, Iwai K

FEBS Lett. 462 巻頁： 216-220 1999年

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. 査読有り

Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A

J. Biol. Chem. 274 巻頁： 14823-14830 1999年

Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. 査読有り

Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A

Proc. Natl. Acad. Sci. USA 96 巻頁： 12436-12441 1999年

Abulia from unilateral capsular genu infarction: report of two cases. 査読有り

Yamanaka K, Fukuyama H, Kimura J

J. Neurol. Sci. 143 巻頁： 181-184 1996年

Plaques of multiple sclerosis on the pyramidal tract demonstrated by MRI.

42 巻頁： 377-378 1995年

Sleep bruxism as a manifestation of subclinical rapid eye movement sleep behavior disorder. 査読有り

Tachibana N, Yamanaka K, Kaji R, Nagamine T, Watatani K, Kimura J, Shibasaki H.

Sleep 17 巻頁： 555-558 1994年

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