論文 - 山中 宏二
-
Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K
ACTA NEUROPATHOLOGICA COMMUNICATIONS 12 巻 ( 1 ) 頁: 184 2024年11月
-
Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K
CELL DEATH & DISEASE 15 巻 ( 11 ) 頁: 858 2024年11月
-
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease 査読有り Open Access
Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K
JOURNAL OF NEUROINFLAMMATION 21 巻 ( 1 ) 頁: 55 2024年2月
-
Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice 査読有り Open Access
Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K
ISCIENCE 27 巻 ( 2 ) 頁: 108872 2024年2月
-
Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS 査読有り
Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 巻 ( 47 ) 頁: e2315347120 2023年11月
-
Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K
SCIENCE ADVANCES 9 巻 ( 31 ) 頁: eadf6895 2023年8月
-
Hashimoto, K; Watanabe, S; Akutsu, M; Muraki, N; Kamishina, H; Furukawa, Y; Yamanaka, K
JOURNAL OF BIOLOGICAL CHEMISTRY 229 巻 ( 6 ) 頁: 104798 2023年6月
-
Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K
NEUROBIOLOGY OF DISEASE 179 巻 頁: 106031 2023年4月
-
Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K
FASEB JOURNAL 35 巻 ( 7 ) 頁: e21688 2021年7月
-
Sobue, A; Komine, O; Hara, Y; Endo, F; Mizoguchi, H; Watanabe, S; Murayama, S; Saito, T; Saido, TC; Sahara, N; Higuchi, M; Ogi, T; Yamanaka, K
ACTA NEUROPATHOLOGICA COMMUNICATIONS 9 巻 ( 1 ) 頁: 1 2021年1月
-
Watanabe, S; Inami, H; Oiwa, K; Murata, Y; Sakai, S; Komine, O; Sobue, A; Iguchi, Y; Katsuno, M; Yamanaka, K
CELL DEATH & DISEASE 11 巻 ( 10 ) 頁: 909 2020年10月
-
Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS 招待有り 査読有り 国際共著
Watanabe S, Ilieva Hristelina, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K
EMBO Molecular Medicine 8 巻 ( 12 ) 頁: 1421-1437 2016年11月
-
Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells 査読有り 国際共著
Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
11 巻 ( 4 ) 頁: 592-604 2015年4月
-
Correction: Long-term systemic androgen deprivation partially modulates neuroinflammation in male App(NL-G-F/NL-G-F) mice.
Maekawa K, Sobue A, Komine O, Saito Y, Murayama S, Saido TC, Saito T, Yamanaka K
Scientific reports 15 巻 ( 1 ) 頁: 19666 2025年6月
-
Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases.
Watanabe S, Yamanaka K
BioEssays : news and reviews in molecular, cellular and developmental biology 頁: e70016 2025年5月
-
Long-term systemic androgen deprivation partially modulates neuroinflammation in male App(NL-G-F/NL-G-F) mice.
Maekawa K, Sobue A, Komine O, Saito Y, Murayama S, Saido TC, Saito T, Yamanaka K
Scientific reports 15 巻 ( 1 ) 頁: 14702 2025年4月
-
Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. 査読有り Open Access
Maetani Y, Kurashige T, Tada Y, Kume K, Watanabe T, Sotomaru Y, Yamanaka K, Maruyama H, Kawakami H
Neuroscience research 216 巻 頁: 104893 2025年3月
-
Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. 査読有り
Fuma K, Iitani Y, Imai K, Ushida T, Tano S, Yoshida K, Yokoi A, Miki R, Kidokoro H, Sato Y, Hara Y, Ogi T, Nomaki K, Tsuda M, Komine O, Yamanaka K, Kajiyama H, Kotani T
Communications biology 8 巻 ( 1 ) 頁: 75 2025年1月
-
Hirayama, T; Morioka, H; Sugisawa, T; Shibukawa, M; Ebina, J; Hanashiro, S; Nagasawa, J; Yanagihashi, M; Okuni, I; Nakajima, T; Murakami, Y; Yamanaka, K; Ebihara, S; Kano, O
JOURNAL OF CLINICAL NEUROSCIENCE 128 巻 頁: 110778 2024年10月
-
Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y
FREE RADICAL BIOLOGY AND MEDICINE 223 巻 頁: 458 - 472 2024年10月
-
Aberrant <i>CHCHD2</i>-associated mitochondriopathy in Kii ALS/PDC astrocytes 査読有り
Leventoux, N; Morimoto, S; Ishikawa, M; Nakamura, S; Ozawa, F; Kobayashi, R; Watanabe, H; Supakul, S; Okamoto, S; Zhou, Z; Kobayashi, H; Kato, C; Hirokawa, Y; Aiba, I; Takahashi, S; Shibata, S; Takao, M; Yoshida, M; Endo, F; Yamanaka, K; Kokubo, Y; Okano, H
ACTA NEUROPATHOLOGICA 147 巻 ( 1 ) 頁: 84 2024年6月
-
Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement 査読有り 国際共著 Open Access
Watanabe, S; Amporndanai, K; Awais, R; Latham, C; Awais, M; O'Neill, PM; Yamanaka, K; Hasnain, SS
SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁: 12118 2024年5月
-
Kawade, N; Yamanaka, K
FEBS OPEN BIO 14 巻 ( 2 ) 頁: 194 - 216 2024年2月
-
An open chat with… Koji Yamanaka
Tsagakis, I; Yamanaka, K
FEBS OPEN BIO 14 巻 ( 2 ) 頁: 162 - 164 2024年2月
-
Adachi, K; Miyata, K; Chida, Y; Hirose, M; Morisaki, Y; Yamanaka, K; Misawa, H
FRONTIERS IN CELLULAR NEUROSCIENCE 17 巻 頁: 1291673 2023年11月
-
Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis 査読有り
Hirayama, T; Shibukawa, M; Yanagihashi, M; Warita, H; Atsuta, N; Yamanaka, K; Kano, O
ACTA NEUROLOGICA BELGICA 123 巻 ( 5 ) 頁: 1797 - 1804 2023年10月
-
Hirayama, T; Shibukawa, M; Morioka, H; Hozumi, M; Tsuda, H; Atsuta, N; Izumi, Y; Nakayama, Y; Shimizu, T; Inoue, H; Urushitani, M; Yamanaka, K; Aoki, M; Ebihara, S; Takeda, A; Kano, O
JOURNAL OF CLINICAL NEUROSCIENCE 116 巻 頁: 87 - 92 2023年10月
-
Matsudaira, T; Nakano, S; Konishi, Y; Kawamoto, S; Uemura, K; Kondo, T; Sakurai, K; Ozawa, T; Hikida, T; Komine, O; Yamanaka, K; Fujita, Y; Yamashita, T; Matsumoto, T; Hara, E
COMMUNICATIONS BIOLOGY 6 巻 ( 1 ) 頁: 665 2023年6月
-
Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease
Sobue, A; Komine, O; Yamanaka, K
INFLAMMATION AND REGENERATION 43 巻 ( 1 ) 頁: 26 2023年5月
-
Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K
FRONTIERS IN CELLULAR NEUROSCIENCE 17 巻 頁: 1160444 2023年3月
-
Role of sex hormones in neuroinflammation in Alzheimer's disease. 招待有り 査読有り
Maekawa K, Yamanaka K.
Clinical and Experimental Neuroimmunology 14 巻 2023年2月
-
Neuroinflammation in neurodegenerative disease 招待有り 査読有り
Yamanaka, K
NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 1 ) 頁: 30 - 32 2023年2月
-
Yamashita, H; Komine, O; Fujimori-Tonou, N; Yamanaka, K
FRONTIERS IN CELLULAR NEUROSCIENCE 16 巻 頁: 1045647 2023年1月
-
Hirose, M; Asano, M; Watanabe-Matsumoto, S; Yamanaka, K; Abe, Y; Yasui, M; Tokuda, E; Furukawa, Y; Misawa, H
NEUROSCIENCE RESEARCH 171 巻 頁: 74 - 82 2021年10月
-
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction 査読有り
Konishi, H; Okamoto, T; Hara, Y; Komine, O; Tamada, H; Maeda, M; Osako, F; Kobayashi, M; Nishiyama, A; Kataoka, Y; Takai, T; Udagawa, N; Jung, SF; Ozato, K; Tamura, T; Tsuda, M; Yamanaka, K; Ogi, T; Sato, K; Kiyama, H
EMBO JOURNAL 39 巻 ( 22 ) 頁: e104464 2020年11月
-
Saifullah, MAB; Komine, O; Dong, YT; Fukumoto, K; Sobue, A; Endo, F; Saito, T; Saido, TC; Yamanaka, K; Mizoguchi, H
MOLECULAR BRAIN 13 巻 ( 1 ) 頁: 147 2020年11月
-
Amporndanai, K; Rogers, M; Watanabe, S; Yamanaka, K; O'Neill, PM; Hasnain, SS
EBIOMEDICINE 59 巻 頁: 102980 2020年9月
-
The regulation of glucose metabolism by astrocytes in diet induced obesity mice
Sugiyama, M; Banno, R; Sun, R; Yaginuma, H; Taki, K; Takagi, H; Ito, Y; Yamanaka, K; Arima, H
DIABETOLOGIA 63 巻 ( SUPPL 1 ) 頁: S266 - S266 2020年9月
-
Sugiyama, M; Banno, R; Yaginuma, H; Taki, K; Mizoguchi, A; Tsunekawa, T; Onoue, T; Takagi, H; Ito, Y; Iwama, S; Goto, M; Suga, H; Komine, O; Yamanaka, K; Arima, H
NEUROCHEMISTRY INTERNATIONAL 136 巻 頁: 104733 2020年6月
-
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair 査読有り 国際共著
Nakazawa, Y; Hara, Y; Oka, Y; Komine, O; van den Heuvel, D; Guo, CW; Daigaku, Y; Isono, M; He, YX; Shimada, M; Kato, K; Jia, N; Hashimoto, S; Kotani, Y; Miyoshi, Y; Tanaka, M; Sobue, A; Mitsutake, N; Suganami, T; Masuda, A; Ohno, K; Nakada, S; Mashimo, T; Yamanaka, K; Luijsterburg, MS; Ogi, T
CELL 180 巻 ( 6 ) 頁: 1228 - + 2020年3月
-
ALS-linked TDP-43<sup>M337V</sup> knock-in mice exhibit splicing deregulation without neurodegeneration. 査読有り
Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K
Molecular brain 13 巻 ( 1 ) 頁: 8 2020年1月
-
Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. 査読有り 国際共著
Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K
Acta neuropathologica communications 7 巻 ( 1 ) 頁: 118 2019年7月
-
Phenotypic heterogeneity of astrocytes in motor neuron disease. 招待有り 査読有り 国際共著
Trias E, Barbeito L, Yamanaka K
Clinical & experimental neuroimmunology 9 巻 ( 4 ) 頁: 225 - 234 2018年11月
-
Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis 査読有り
Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H
Neuroscience Research 133 巻 頁: 48-57 2018年8月
-
A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis
Tokuda Eiichi, Nomura Takao, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1864 巻 ( 6 ) 頁: 2119 - 2130 2018年6月
-
Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice 査読有り
Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K
Journal of Neurochemistry 145 巻 ( 1 ) 頁: 80-89 2018年4月
-
Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. 査読有り
Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K
Cell Death and Differentiation 25 巻 ( 12 ) 頁: 2130-2146 2018年3月
-
The Multi-dimensional roles of astrocytes in ALS. 招待有り 査読有り
Yamanaka K, Komine O
Neuroscience Research 126 巻 頁: 31 - 38 2018年1月
-
TDP-43 accelerates age-dependent degeneration of interneurons 査読有り
Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K
Scientific Reports 7 巻 頁: 14972 2017年11月
-
Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS
Endo, F; Kurita, T; Yamanaka, K
JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻 頁: 203 - 204 2017年10月
-
Watanabe, S; Ilieva, H; Tamada, H; Nomura, H; Komine, O; Endo, F; Jin, S; Mancias, P; Kiyama, H; Yamanaka, K
JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻 頁: 104 - 104 2017年10月
-
Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction
Nishino K, Watanabe S, Komine O, Yamanaka K.
Journal of the Neurological Sciences 381 巻 頁: 570 2017年10月
-
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. 査読有り
Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H
Scientific Reports 7 巻 頁: 7348 2017年8月
-
A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis. 査読有り
Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y.
Protein Sci 26 巻 ( 3 ) 頁: 484-496 2017年3月
-
A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis
Anzai Itsuki, Tokuda Eiichi, Mukaiyama Atsushi, Akiyama Shuji, Endo Fumito, Yamanaka Koji, Misawa Hidemi, Furukawa Yoshiaki
PROTEIN SCIENCE 26 巻 ( 3 ) 頁: 484 - 496 2017年3月
-
Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. 査読有り
Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
Molecular Neurodegeneration 12 巻 頁: 2 2017年1月
-
Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis
Tokuda Eiichi, Anzai Itsuki, Nomura Takao, Toichi Keisuke, Watanabe Masahiko, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki
MOLECULAR NEURODEGENERATION 12 巻 ( 1 ) 頁: 2 2017年1月
-
Proteasomal dysfunction induced by diclofenac engenders apoptosis through mitochondrial pathway
Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A
J. Cell. Biochem. 2016年8月
-
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 査読有り
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
Scientific Reports 6 巻 頁: 27354 2016年6月
-
Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. 査読有り
Lasiene J, Komine O, Fujimori-Tonou. N, Powers B, Endo F, Watanabe S, Shjie J, Ravits J, Horner P, Misawa H, Yamanaka K
Acta Neuropathologica Communications 18 巻 ( 4 ) 2016年2月
-
Neuroinflammation in motor neuron disease.
Komine O, Yamanaka K
Nagoya Journal of Medical Science 77 巻 ( 4 ) 頁: 537-549 2015年11月
-
Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model. 査読有り 国際共著
Chhangani D, Endo F, Amanullah A, Upadhyay A, Watanabe S, Mishra R, Yamanaka K, Mishra A
Neurobiology of Disease 86 巻 頁: 16-28 2015年11月
-
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. 査読有り
Watanabe S, Hayakawa T, Wakasugi K, Yamanaka K
Cell Death and Disease 5 巻 頁: e1497 2014年10月
-
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. 査読有り
Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K
Molecular Brain 7 巻 ( 62 ) 2014年8月
-
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. 査読有り
Austin James J., Wright Gareth S., Watanabe S, Grossman G, Antonyuk S V., Yamanaka K, Hasnan S. S
Proceedings of the National Academy of Sciences of the United States of America 111 巻 ( 11 ) 頁: 4309-4314 2014年3月
-
Case of familial amyotrophic lateral sclerosis showing gadolinium-enhanced cranial nerves on magnetic resonance imaging associated with rapid progression of facial nerve palsy 査読有り
Mizuno M, Ueki Y, Sakurai K, Okita K, Endo F, Yamanaka K, Morita M, Matsukawa N
Neurology and Clinical Neuroscience 頁: -- 2014年2月
-
Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis 査読有り
Nomura T, Watanabe S, Kaneko K, Yamanaka K, Nukina N, Furukawa Y
Journal of Biological Chemistry 289 巻 ( 2 ) 頁: 1192-1202 2014年1月
-
Animal models for neurodegenerative disorders
Tsuiji H, Yamanaka K
Animal Biotechnology 頁: 39-56 2013年12月
-
Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis 査読有り
Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N
FEBS Letters 587 巻 ( 16 ) 頁: 2500-2505 2013年8月
-
E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 査読有り
Mishra Amit K, Maheshiwari M, Chhangani D, Fujimori-T N, Endo F, Joshi Ajai P, Jana Nihar R, Yamanaka K
Neurobiology of Aging 34 巻 ( 4 ) 頁: 1310.e11-23 2013年4月
-
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. 査読有り
Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka , Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki Shoichi, Tanaka F, Sobue G
Brain 136 巻 ( 5 ) 頁: 1371-1382 2013年2月
-
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. 査読有り
Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, Tanaka F, Hashizume Y, Akatsu H, Murayama S, Sobue G, Yamanaka K
EMBO Molecular Medicine 5 巻 ( 2 ) 頁: 221-234 2013年2月
-
Deletion of TLR-Associted signaling adaptor TRIF significantly accelerates disease progression of ALS mice. 査読有り
Komine O, Fujimori-Tonou N, Yamashita H, Moriwaki Y, Misawa H, Yamanaka K
61 巻 頁: S75-S76 2013年
-
The role of microglia-immune interaction in neurodegeneration of ALS mouse model.
Yamanaka K
Journal of Neurochemistry 125 巻 頁: 89 2013年
-
Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked TDP-43 mutations. 査読有り
Watanabe S, Kaneko K, Yamanaka K
J Biol Chem 288 巻 頁: 3641-3654 2012年12月
-
Disulfide scrambling describes the oligomer formation of SOD1 proteins in the familial form of ALS. 査読有り
Toichi K, Yamanaka K, Furukawa Y
J Biol Chem 288 巻 頁: 4970-1980 2012年12月
-
E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity. 査読有り
Mishra A, Maheshwari M, Chhangani D, Fujimori-Tonou N, Endo, F, Joshi AP, Jana NR, Yamanaka K
Neurobiol Aging 34 巻 ( 1310 ) 頁: e11-23 2012年10月
-
A seeding reaction recapitulates intracellular formation of sarkosyl-insoluble TAR DNA binding protein-43 inclusions. 査読有り
Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N
J. Biol. Chem 286 巻 頁: 18664-18672 2011年
-
Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's 査読有り
Takeuchi H, Mizoguchi H, Doi Y, Jin S, Noda M, Liang J, Li H, Zhou Y, Mori R, Yasuoka S, Li E, Parajuli B, Kawanokuchi J, Sonobe Y, Sato J, Yamanaka K, Sobue G, Mizuno T, Suzumura A
PLoS One 6 巻 ( 6 ) 頁: e21108 2011年
-
Glial cells in Amyotrophic Lateral Sclerosis. 査読有り
Lasiene J, Yamanaka K
Neurol Res Int 頁: 718987 2011年
-
Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis. 査読有り
Furukawa Y, Kaneko K, Yamanaka K, Nukina N
J. Biol. Chem. 285 巻 頁: 22221-22231 2010年
-
Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS. 査読有り
Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan-Barmatz V, Clevalend DW
Neuron 67 巻 頁: 575-587 2010年
-
Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. 査読有り
Lobsiger CS, Boillee S, McAlonis-Downes M, Khan AM, Feltri ML, Yamanaka K, Cleveland DW
Proc. Natl. Acad. Sci., USA. 106 巻 頁: 4465-4470 2009年
-
Gigaxonin controls vimentin organization through tubulin chaperone-independent pathway. 査読有り
Cleveland DW, Yamanaka K, Bomont P
Hum. Mol. Genet. 18 巻 頁: 1384-1394 2009年
-
Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. 査読有り
Ilieva H, Yamanaka K, Malkmus S, Kakinohana O, Yaksh T, Marsala M, Cleveland DW
Proc. Natl. Acad. Sci., USA. 105 巻 頁: 12599-12604 2008年
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. 査読有り
Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW
Nat. Neurosci. 11 巻 頁: 251-253 2008年
-
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. 査読有り
Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LSB
Proc. Natl. Acad. Sci., USA. 105 巻 頁: 7594-7599 2008年
-
Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in familial form of ALS. 査読有り
Furukawa Y, Kaneko K, Yamanaka K, O'Halloran, TV, Nukina N
J. Biol. Chem. 283 巻 頁: 24167-24176 2008年
-
Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase; clues to a possible strategy for treating ALS. 査読有り
Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S
J. Neurochem. 102 巻 頁: 1497-1505 2007年
-
Onset and Progression in Inherited ALS determined by Motor Neurons and Microglia. 査読有り
Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW
Science 312 巻 頁: 1389-1392 2006年
-
Novel Missense Mutation in ALS2 gene results in Infantile Ascending Hereditary Spastic Paralysis. 査読有り
Eymard-Pierre E, Yamanaka K, Haeussler M, Kress W, Gauthier-Barichard F, Combes P, Cleveland DW, Boespflug-Tanguy O
Ann. Neurol. 59 巻 頁: 976-980 2006年
-
Progressive axonal degeneration and slowness in ALS2-deficient mice. 査読有り
Yamanaka K, Miller TM, McAlonis-Downes M, Chun SJ, Cleveland DW
Ann. Neurol. 60 巻 頁: 95-104 2006年
-
Antisense Oligonucleotides as a Therapy for Neurodegenerative diseases. 査読有り
Smith RA, Miller TM, Yamanaka K, Monia BP, Condon TP, Hung G, Lobsiger CS, Ward CM, McAlonis-Downes M, Wei H, Wancewicz EV, Bennett CF, Cleveland DW
J. Clin. Invest. 116 巻 頁: 2290-2296 2006年
-
Gene transfer demonstrates that muscle is not a primary target for non-cell autonomous toxicity in familial amyotrophic lateral sclerosis. 査読有り
Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK
Proc. Natl. Acad. Sci. USA 103 巻 頁: 19546-19551 2006年
-
Virus-delivered siRNA preserves strength in ALS mice. 査読有り
Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW
Ann. Neurol. 57 巻 頁: 773-776 2005年
-
Cleveland DW: Determinants of rapid disease progression in ALS. 査読有り
Yamanaka K
Neurology 65 巻 頁: 1859-1860 2005年
-
ALS2-Related Disorders. 査読有り
Bertini E, Eymard-Pierre E, Boespflug-Tanguy O, Cleveland DW, Yamanaka K
GeneReviews at GeneTests: Medical Genetics Information Resource. 頁: 00 2005年
-
Unstable mutants in the peripheral endosomal membrane component ALS2 cause early onset motor neuron disease. 査読有り
Yamanaka K, Vande Velde C, Eymard-Pierre E, Bertini E, Boespflug-Tanguy O, Cleveland DW
Proc. Natl. Acad. Sci. USA 100 巻 頁: 16041-16046 2003年
-
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. 査読有り
Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K
Nat. Cell Biol. 5 巻 頁: 336-340 2003年
-
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. 査読有り
Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, Minato N, Suzuki H, Shimbara N, Hidaka Y, Osaka F, Omata M, Tanaka K
EMBO J. 20 巻 頁: 4003-4012 2001年
-
Multiple thymoma with myotonic dystrophy. 査読有り
Hirai T, Yamanaka A, Fujimoto T, Takahashi A, Takayama Y, Yamanaka K
Japanese Journal Thoracic Cardiovascular Surgery 49 巻 頁: 457-460 2001年
-
Stabilization of iron regulatory protein 2, IRP2, by aluminum. 査読有り
Yamanaka K, Minato N, Iwai K
FEBS Lett. 462 巻 頁: 216-220 1999年
-
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. 査読有り
Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A
J. Biol. Chem. 274 巻 頁: 14823-14830 1999年
-
Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. 査読有り
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A
Proc. Natl. Acad. Sci. USA 96 巻 頁: 12436-12441 1999年
-
Abulia from unilateral capsular genu infarction: report of two cases. 査読有り
Yamanaka K, Fukuyama H, Kimura J
J. Neurol. Sci. 143 巻 頁: 181-184 1996年
-
Plaques of multiple sclerosis on the pyramidal tract demonstrated by MRI.
42 巻 頁: 377-378 1995年
-
Sleep bruxism as a manifestation of subclinical rapid eye movement sleep behavior disorder. 査読有り
Tachibana N, Yamanaka K, Kaji R, Nagamine T, Watatani K, Kimura J, Shibasaki H.
Sleep 17 巻 頁: 555-558 1994年