研究者詳細 - 山中　宏二

論文 - 山中　宏二

分割表示 104 件中 1 - 20 件目／全件表示 >>

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice 査読有り

Horiuchi, M; Watanabe, S; Komine, O; Takahashi, E; Kaneko, K; Itohara, S; Shimada, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 12 巻 ( 1 ) 頁： 184 2024年11月

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation 査読有り

Sobue, A; Komine, O; Endo, F; Kakimi, C; Miyoshi, Y; Kawade, N; Watanabe, S; Saito, Y; Murayama, S; Saido, TC; Saito, T; Yamanaka, K

CELL DEATH & DISEASE 15 巻 ( 11 ) 頁： 858 2024年11月

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease 査読有り Open Access

Wang, T; Sobue, A; Watanabe, S; Komine, O; Saido, TC; Saito, T; Yamanaka, K

JOURNAL OF NEUROINFLAMMATION 21 巻 ( 1 ) 頁： 55 2024年2月

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice 査読有り Open Access

Komine, O; Ohnuma, S; Hinohara, K; Hara, Y; Shimada, M; Akashi, T; Watanabe, S; Sobue, A; Kawade, N; Ogi, T; Yamanaka, K

ISCIENCE 27 巻 ( 2 ) 頁： 108872 2024年2月

Mitochondria- associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS 査読有り

Watanabe, S; Murata, Y; Oka, Y; Oiwa, K; Horiuchi, M; Iguchi, Y; Komine, O; Sobue, A; Katsuno, M; Ogi, T; Yamanaka, K

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 巻 ( 47 ) 頁： e2315347120 2023年11月

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis 査読有り

Oiwa, K; Watanabe, S; Onodera, K; Iguchi, Y; Kinoshita, Y; Komine, O; Sobue, A; Okada, Y; Katsuno, M; Yamanaka, K

SCIENCE ADVANCES 9 巻 ( 31 ) 頁： eadf6895 2023年8月

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation 査読有り

Hashimoto, K; Watanabe, S; Akutsu, M; Muraki, N; Kamishina, H; Furukawa, Y; Yamanaka, K

JOURNAL OF BIOLOGICAL CHEMISTRY 229 巻 ( 6 ) 頁： 104798 2023年6月

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis 査読有り

Watanabe, S; Horiuchi, M; Murata, Y; Komine, O; Kawade, N; Sobue, A; Yamanaka, K

NEUROBIOLOGY OF DISEASE 179 巻頁： 106031 2023年4月

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis 査読有り

Sakai, S; Watanabe, S; Komine, O; Sobue, A; Yamanaka, K

FASEB JOURNAL 35 巻 ( 7 ) 頁： e21688 2021年7月

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease 査読有り

Sobue, A; Komine, O; Hara, Y; Endo, F; Mizoguchi, H; Watanabe, S; Murayama, S; Saito, T; Saido, TC; Sahara, N; Higuchi, M; Ogi, T; Yamanaka, K

ACTA NEUROPATHOLOGICA COMMUNICATIONS 9 巻 ( 1 ) 頁： 1 2021年1月

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43 査読有り

Watanabe, S; Inami, H; Oiwa, K; Murata, Y; Sakai, S; Komine, O; Sobue, A; Iguchi, Y; Katsuno, M; Yamanaka, K

CELL DEATH & DISEASE 11 巻 ( 10 ) 頁： 909 2020年10月

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS 招待有り査読有り国際共著

Watanabe S, Ilieva Hristelina, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, Yamanaka K

EMBO Molecular Medicine 8 巻 ( 12 ) 頁： 1421-1437 2016年11月

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells 査読有り国際共著

Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K

11 巻 ( 4 ) 頁： 592-604 2015年4月

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression. 査読有り Open Access

Maetani Y, Kurashige T, Tada Y, Kume K, Watanabe T, Sotomaru Y, Yamanaka K, Maruyama H, Kawakami H

Neuroscience research 2025年3月

Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders. 査読有り

Fuma K, Iitani Y, Imai K, Ushida T, Tano S, Yoshida K, Yokoi A, Miki R, Kidokoro H, Sato Y, Hara Y, Ogi T, Nomaki K, Tsuda M, Komine O, Yamanaka K, Kajiyama H, Kotani T

Communications biology 8 巻 ( 1 ) 頁： 75 2025年1月

A preliminary study on the effects of long-term robot suit exercise training on gait function and quality of life in patients with spinal and bulbar muscular atrophy 査読有り

Hirayama, T; Morioka, H; Sugisawa, T; Shibukawa, M; Ebina, J; Hanashiro, S; Nagasawa, J; Yanagihashi, M; Okuni, I; Nakajima, T; Murakami, Y; Yamanaka, K; Ebihara, S; Kano, O

JOURNAL OF CLINICAL NEUROSCIENCE 128 巻頁： 110778 2024年10月

Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia 査読有り

Fujisawa, H; Watanabe, T; Komine, O; Fuse, S; Masaki, M; Iwata, N; Murao, N; Seino, Y; Takeuchi, H; Yamanaka, K; Sawada, M; Suzuki, A; Sugimura, Y

FREE RADICAL BIOLOGY AND MEDICINE 223 巻頁： 458 - 472 2024年10月

Aberrant <i>CHCHD2</i>-associated mitochondriopathy in Kii ALS/PDC astrocytes 査読有り

Leventoux, N; Morimoto, S; Ishikawa, M; Nakamura, S; Ozawa, F; Kobayashi, R; Watanabe, H; Supakul, S; Okamoto, S; Zhou, Z; Kobayashi, H; Kato, C; Hirokawa, Y; Aiba, I; Takahashi, S; Shibata, S; Takao, M; Yoshida, M; Endo, F; Yamanaka, K; Kokubo, Y; Okano, H

ACTA NEUROPATHOLOGICA 147 巻 ( 1 ) 頁： 84 2024年6月

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement 査読有り国際共著 Open Access

Watanabe, S; Amporndanai, K; Awais, R; Latham, C; Awais, M; O'Neill, PM; Yamanaka, K; Hasnain, SS

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 12118 2024年5月

Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities 招待有り査読有り

Kawade, N; Yamanaka, K

FEBS OPEN BIO 14 巻 ( 2 ) 頁： 194 - 216 2024年2月

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