論文 - 山中 宏二
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ALS-linked TDP-43<sup>M337V</sup> knock-in mice exhibit splicing deregulation without neurodegeneration. 査読有り
Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K
Molecular brain 13 巻 ( 1 ) 頁： 8 2020年1月
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Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. 査読有り 国際共著
Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K
Acta neuropathologica communications 7 巻 ( 1 ) 頁： 118 2019年7月
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Phenotypic heterogeneity of astrocytes in motor neuron disease. 招待有り 査読有り 国際共著
Trias E, Barbeito L, Yamanaka K
Clinical & experimental neuroimmunology 9 巻 ( 4 ) 頁： 225 - 234 2018年11月
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Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis 査読有り
Watanabe-Matsumoto S, Moriwaki Y, Okuda T, Ohara S, Yamanaka K, Abe Y, Yasui M, Misawa H
Neuroscience Research 133 巻 頁： 48-57 2018年8月
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A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis
Tokuda Eiichi, Nomura Takao, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1864 巻 ( 6 ) 頁： 2119 - 2130 2018年6月
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Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice 査読有り
Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K
Journal of Neurochemistry 145 巻 ( 1 ) 頁： 80-89 2018年4月
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Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. 査読有り
Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K
Cell Death and Differentiation 25 巻 ( 12 ) 頁： 2130-2146 2018年3月
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The Multi-dimensional roles of astrocytes in ALS. 招待有り 査読有り
Yamanaka K, Komine O
Neuroscience Research 126 巻 頁： 31 - 38 2018年1月
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TDP-43 accelerates age-dependent degeneration of interneurons 査読有り
Tsuiji H, Inoue I, Takeuchi M, Furuya A, Yamakage Y, Watanabe S, Koike M, Hattori M, Yamanaka K
Scientific Reports 7 巻 頁： 14972 2017年11月
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Astrocyte-derived extracellular vesicles contribute to the propagation of pathogenic protein in ALS
Endo, F; Kurita, T; Yamanaka, K
JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻 頁： 203 - 204 2017年10月
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Watanabe, S; Ilieva, H; Tamada, H; Nomura, H; Komine, O; Endo, F; Jin, S; Mancias, P; Kiyama, H; Yamanaka, K
JOURNAL OF THE NEUROLOGICAL SCIENCES 381 巻 頁： 104 - 104 2017年10月
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Mice heterozygously lacking C-terminal domain of TDP-43 show age-dependent motor dysfunction
Nishino K, Watanabe S, Komine O, Yamanaka K.
Journal of the Neurological Sciences 381 巻 頁： 570 2017年10月
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Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. 査読有り
Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H
Scientific Reports 7 巻 頁： 7348 2017年8月
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A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis. 査読有り
Anzai I, Tokuda E, Mukaiyama A, Akiyama S, Endo F, Yamanaka K, Misawa H, Furukawa Y.
Protein Sci 26 巻 ( 3 ) 頁： 484-496 2017年3月
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A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis
Anzai Itsuki, Tokuda Eiichi, Mukaiyama Atsushi, Akiyama Shuji, Endo Fumito, Yamanaka Koji, Misawa Hidemi, Furukawa Yoshiaki
PROTEIN SCIENCE 26 巻 ( 3 ) 頁： 484 - 496 2017年3月
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Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis. 査読有り
Tokuda E, Anzai I, Nomura T, Toichi K, Watanabe M, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y.
Molecular Neurodegeneration 12 巻 頁： 2 2017年1月
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Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis
Tokuda Eiichi, Anzai Itsuki, Nomura Takao, Toichi Keisuke, Watanabe Masahiko, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki
MOLECULAR NEURODEGENERATION 12 巻 ( 1 ) 頁： 2 2017年1月
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Proteasomal dysfunction induced by diclofenac engenders apoptosis through mitochondrial pathway
Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A
J. Cell. Biochem. 2016年8月
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Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 査読有り
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
Scientific Reports 6 巻 頁： 27354 2016年6月
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Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons. 査読有り
Lasiene J, Komine O, Fujimori-Tonou. N, Powers B, Endo F, Watanabe S, Shjie J, Ravits J, Horner P, Misawa H, Yamanaka K
Acta Neuropathologica Communications 18 巻 ( 4 ) 2016年2月