研究者詳細 - 吉村　崇

論文 - 吉村　崇

分割表示 214 件中 141 - 160 件目／全件表示 >>

Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone

Anraku Tsubasa, Takagi Tsuyoshi, Nakao Nobuhiro, Watanabe Miwa, Yasuo Shinobu, Katou Yasuhiro, Ueda Yukihiro, Murai Atsushi, Ligo Masayuki, Ebihara Shizufumi, Yoshimura Takashi

BRAIN RESEARCH 1163 巻頁： 86 - 90 2007年8月

Circadian clock gene regulation of steroidogenic acute regulatory protein gene expression in preovulatory ovarian follicles

Nakao Nobuhiro, Yasuo Shinobu, Nishimura Atsuko, Yamamura Takashi, Watanabe Tsuyoshi, Anraku Tsubasa, Okano Toshiyuki, Fukada Yoshitaka, Sharp Peter J., Ebihara Shizufumi, Yoshimura Takashi

ENDOCRINOLOGY 148 巻 ( 7 ) 頁： 3031 - 3038 2007年7月

Molecular evolution of prepro-thyrotropin-releasing hormone in the chicken (<i>Gallus gallus</i>) and its expression in the brain 査読有り

Aoki Yasuhiro, Ono Hiroko, Yasuo Shinobu, Masuda Tomohiro, Yoshimura Takashi, Ebihara Shizufumi, Jigo Masayuki, Yanagisawa Tadashi

ZOOLOGICAL SCIENCE 24 巻 ( 7 ) 頁： 686 - 692 2007年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：7

A cDNA encoding prepro-thyrotropin-relaesing hormone (ppTRH) in chicken (Callus gallus) was isolated and the sites of expression in the brain were determined. The chicken ppTRH cDNA encodes 260 amino acids, including four TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-). It is interesting to note that chicken ppTRH harbors four TRH progenitor-like sequences. According to the hydropathy profile of chicken ppTRH, not only the TRH progenitor sequences but also the TRH progenitor-like sequences are localized in hydrophilic regions. The TRH progenitor-like sequences might be related to structural conservation in the evolution of ppTRH, although they cannot be processed into TRH due to the mutation of several amino acids. According to the alignment of the deduced amino-acid sequences of known vertebrate ppTRHs and the molecular phylogenetic tree we constructed, we speculate on the molecular evolution of ppTRH in vertebrates. In situ hybridization demonstrated experession of the ppTRH gene in the nucleus preopticus periventricularis, nucleus preopticus medialis, regio lateralis hypothalami, paraventricular nucleus, nucleus periventricularis hypothalami, and nucleus ventromedialis hypothalami in the chicken brain. © 2007 Zoological Society of Japan.

DOI： 10.2108/zsj.24.686

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PubMed

Involvement of transforming growth factor alpha in the photoperiodic regulation of reproduction in birds

Takagi Tsuyoshi, Yamamura Takashi, Anraku Tsubasa, Yasuo Shinobu, Nakao Nobuhiro, Watanabe Miwa, Iigo Masayuki, Ebihara Shizufumi, Yoshimura Takashi

ENDOCRINOLOGY 148 巻 ( 6 ) 頁： 2788 - 2792 2007年6月

Bimodal clock gene expression in mouse suprachiasmatic nucleus and peripheral tissues under a 7-hour light and 5-hour dark schedule 査読有り

Watanabe Tsuyoshi, Naito Emiko, Nakao Nobuhiro, Tei Hajime, Yoshimura Takashi, Ebihara Shizufumi

JOURNAL OF BIOLOGICAL RHYTHMS 22 巻 ( 1 ) 頁： 58 - 68 2007年2月

出版者・発行元：Journal of Biological Rhythms

Using the mPer1::luc real-time monitoring technique, the authors observed the bimodal patterns of mPer1 bioluminescence on each side of the SCN, in parallel with maintaining synchronization between the left and right sides of the SCN under an artificial light:dark:light:dark (LDLD) 7:5:7:5 condition. In situ hybridization analysis of mPer1 and mBmal1 mRNA distribution in the SCN showed that in 1 photophase (morning photophase; M) of LDLD, the mPer1 level in the ventrolateral-like (VL-like) subdivision of the SCN was higher than that in the dorsomedial-like (DM-like) subdivision, and this regional distribution pattern was reversed in another photophase (evening photophase; E). In contrast, the mBmal1 level was higher in the DM-like subdivision than in the VL-like subdivision in the M phase, and this distribution changed in the E phase. The prokineticin 2 (PK2) mRNA that encodes an SCN output molecule that is thought to transmit the circadian locomotor rhythms was reduced in both the DM-like and VL-like SCN and did not clearly correlate with the activity under the LDLD condition. The expression of mPer1 and mPer2 in the liver was clearly bimodal, whereas the expressions of other clock genes were not synchronized to the LDLD condition. These results may provide important insights into the mechanism underlying the splitting or bimodal rhythms that may in turn facilitate the understanding of the ability to measure the seasonal day length in mammals. © 2007 Sage Publications.

DOI： 10.1177/0748730406295435

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PubMed

Hypothalamic expression of thyroid hormone-activating and -inactivating enzyme genes in relation to photorefractoriness in birds and mammals 査読有り

Watanabe T, Yamamura T, Watanabe M, Yasuo S, Nakao N, Dawson A, Ebihara S, Yoshimura T

American Journal of Physiology 292 巻頁： R568-R572 2007年

時計遺伝子の進化招待有り

吉村崇, 海老原史樹文

生体の科学 57 巻頁： 440-441 2007年

Photoperiodic changes in hypothalamic insulin receptor gene expression are regulated by gonadal testosterone 査読有り

1163 巻頁： 86-90 2007年

Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters 査読有り

Yasuo S, Yoshimura T, Ebihara S, Korf HW

Endocrinology 148 巻頁： 4385-4392 2007年

Involvement of transforming growth factor alpha in the photoperiodic regulation of reproduction in birds. 査読有り

Takagi T, Yamamura T, Anraku T, Yasuo S, Nakao N, Watanabe M, Iigo M, Ebihara S, Yoshimura T

Endocrinology 148 巻頁： 2788-2792 2007年

Differential response of type 2 deiodinase gene expression to photoperiod between photoperiodic F344 and nonphotoperiodic Wistar rats 査読有り

Yasuo S, Watanabe M, Iigo M, Nakamura TJ, Watanabe T, Takagi T, Ono H, Ebihara S, Yoshimura T

American Journal of Physiology 292 巻頁： R1315-R1319 2007年

Photoperiodic regulation of seasonal reproduction in birds

Yoshimura T., Yasuo S., Nakao N., Yamamura T., Ebihara S.

JOURNAL OF ORNITHOLOGY 147 巻 ( 5 ) 頁： 65 - 65 2006年8月

Overview of avian circadian system

Ebihara S., Yasuo S., Tada A., Yoshimura T.

JOURNAL OF ORNITHOLOGY 147 巻 ( 5 ) 頁： 64 - 65 2006年8月

Reciprocal switching of type 2 and type 3 deiodinase genes triggers photoperiodic gonadal response in Japanese Quail

Yasuo S., Watanabe M., Nakao N., Takagi T., Ebihara S., Yoshimura T.

JOURNAL OF ORNITHOLOGY 147 巻 ( 5 ) 頁： 276 - 277 2006年8月

Molecular mechanism of the photoperiodic response of gonads in birds and mammals

Yoshimura Takashi

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 144 巻 ( 3 ) 頁： 345 - 350 2006年7月

記述言語：英語出版者・発行元：Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Appropriate timing of various seasonal processes is crucial to the survival and reproductive success of animals living in temperate regions. When seasonally breeding animals are subjected to annual changes in day length, dramatic changes in neuroendocrine-gonadal activity take place. However, the molecular mechanism underlying the photoperiodic response of gonads remains unknown for all living organisms. It is well known that a circadian clock is somehow involved in the regulation of photoperiodism. Recently, rhythmic expression of circadian clock genes was observed in the mediobasal hypothalamus (MBH) of Japanese quail. The MBH is believed to be the center for photoperiodism. In addition, long-day-induced hormone conversion of the prohormone thyroxine (T4) to the bioactive triiodothyronine (T3) by deiodinase in the MBH has been proven to be important to the photoperiodic response of the gonads. Although the regulating mechanism for the photoperiodic response of gonads in birds and mammals has long been considered to be quite different, the long-day-induced expression of the deiodinase gene in the hamster hypothalamus suggests the existence of a conserved regulatory mechanism in avian and mammalian photoperiodism. © 2005 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.cbpa.2005.09.009

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T<sub>3</sub> implantation mimics photoperiodically reduced encasement of nerve terminals by glial processes in the median eminence of Japanese quail

Yamamura T, Yasuo S, Hirunagi K, Ebihara S, Yoshimura T

CELL AND TISSUE RESEARCH 324 巻 ( 1 ) 頁： 175 - 179 2006年4月

出版者・発行元：Cell and Tissue Research

Photoperiodically generated triiodothyronin (T3) in the mediobasal hypothalamus (MBH) has critical roles in the photoperiodic response of the gonads in Japanese quail. In a previous study, we demonstrated seasonal morphological changes in the neuro-glial interaction between gonadotrophin-releasing hormone (GnRH) nerve terminals and glial endfeet in the median eminence (ME). However, a direct relationship between photoperiodically generated T3 and seasonal neuro-glial plasticity in the ME remained unclear. In the present study, we examined the effect of T3 implantation into the MBH on the neuro-glial interaction in the ME. T 3 implantation caused testicular growth and reduced encasement of nerve terminals in the external zone of the ME. In contrast, no morphological changes were observed in birds given an excessive dose of T3, which did not cause testicular growth. These results support the hypothesis that thyroid hormone regulates photoperiodic GnRH secretion via neuro-glial plasticity in the ME. © Springer-Verlag 2006.

DOI： 10.1007/s00441-005-0126-8

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Scopus

Peripheral clock gene expression in CS mice with bimodal locomotor rhythms 査読有り

Watanabe T, Kojima M, Tomida S, Nakamura TJ, Yamamura T, Nakao N, Yasuo S, Yoshimura T, Ebihara S

NEUROSCIENCE RESEARCH 54 巻 ( 4 ) 頁： 295 - 301 2006年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：4

CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN. © 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

DOI： 10.1016/j.neures.2005.12.009

Possible involvement of organic anion transporting polypeptide 1c1 in the photoperiodic response of gonads in birds

Nakao N, Takagi T, Iigo M, Tsukamoto T, Yasuo S, Masuda T, Yanagisawa T, Ebihara S, Yoshimura T

ENDOCRINOLOGY 147 巻 ( 3 ) 頁： 1067 - 1073 2006年3月

Molecular analysis of photoperiodic time measurement in birds and mammals

Yoshimura T

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-COMPARATIVE EXPERIMENTAL BIOLOGY 305A 巻 ( 2 ) 頁： 196 - 196 2006年2月

Long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the saanen goat, a short-day breeder: Implication for seasonal window of thyroid hormone action on reproductive neuroendocrine

Yasuo S, Nakao N, Ohkura S, Iigo M, Hagiwara S, Goto A, Ando H, Yamamura T, Watanabe M, Watanabe T, Oda SI, Maeda KI, Lincoln GA, Okamura H, Ebihara S, Yoshimura T

ENDOCRINOLOGY 147 巻 ( 1 ) 頁： 432 - 440 2006年1月

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