研究者詳細 - 吉村　崇

論文 - 吉村　崇

分割表示 214 件中 41 - 60 件目／全件表示 >>

Seasonal reproduction: Photoperiodism, birds

Nakane Y., Yoshimura T.

Encyclopedia of Reproduction 頁： 409 - 414 2018年1月

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Encyclopedia of Reproduction

Seasonal changes in photoperiod are crucial cues for seasonal reproduction in birds inhabiting non-tropical regions. Birds possess photoreceptors in their eyes, pineal organs, and deep brain regions. It is known that birds detect light information of photoperiod, via deep brain photoreceptors. Several studies have revealed that photoinduced thyroid-stimulating hormone, originating from the pars tuberalis of the pituitary gland, prompt the local activation of thyroid hormone in the hypothalamus, which in turn leads to morphological changes in neurons and the secretion of gonadotropin-releasing hormone. In this article, we describe the mechanism for photoperiodism, using the seasonal reproduction of birds as an example.

DOI： 10.1016/B978-0-12-809633-8.20585-2

Scopus

Seasonal Rhythms: The Role of Thyrotropin and Thyroid Hormones

Nakayama Tomoya, Yoshimura Takashi

THYROID 28 巻 ( 1 ) 頁： 4 - 10 2018年1月

Seasonal Regulation of Reproduction in Vertebrates: Special Focus on Avian Strategy

Shinomiya Ai, Yoshimura Takashi

REPRODUCTIVE AND DEVELOPMENTAL STRATEGIES: THE CONTINUITY OF LIFE 頁： 103 - + 2018年

季節性と色覚－メダカの色覚は季節によってダイナミックに変化する招待有り

新村毅，吉村崇

遺伝 72 巻頁： 617 - 622 2018年

Dynamic plasticity in phototransduction regulates seasonal changes in color perception

Shimmura T., Nakayama T., Shinomiya A., Fukamachi S., Yasugi M., Watanabe E., Shimo T., Senga T., Nishimura T., Tanaka M., Kamei Y., Naruse K., Yoshimura T.

Nature Communications 8 巻 ( 1 ) 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Communications

To cope with seasonal changes in the environment, organisms adapt their physiology and behavior. Although color perception varies among seasons, the underlying molecular basis and its physiological significance remain unclear. Here we show that dynamic plasticity in phototransduction regulates seasonal changes in color perception in medaka fish. Medaka are active and exhibit clear phototaxis in conditions simulating summer, but remain at the bottom of the tank and fail to exhibit phototaxis in conditions simulating winter. Mate preference tests using virtual fish created with computer graphics demonstrate that medaka are more attracted to orange-red-colored model fish in summer than in winter. Transcriptome analysis of the eye reveals dynamic seasonal changes in the expression of genes encoding photopigments and their downstream pathways. Behavioral analysis of photopigment-null fish shows significant differences from wild type, suggesting that plasticity in color perception is crucial for the emergence of seasonally regulated behaviors.

DOI： 10.1038/s41467-017-00432-8

Web of Science

Scopus

The hypothalamic-pituitary-thyroid axis and biological rhythms: The discovery of TSH's unexpected role using animal models 国際誌

Ikegami Keisuke, Yoshimura Takashi

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM 31 巻 ( 5 ) 頁： 475 - 485 2017年10月

Molecular mechanism regulating seasonality 査読有り

Ikegami K., Yoshimura T.

Biological Timekeeping: Clocks, Rhythms and Behaviour 頁： 589 - 605 2017年1月

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Biological Timekeeping: Clocks, Rhythms and Behaviour

The mechanisms of vertebrate seasonal time measurement were a mystery for a long time, but recent comparative studies have uncovered the photoperiodic signal transduction cascades in birds, mammals, and fish. These studies reveal the universality and diversity of photoperiodic mechanisms. That is, the molecules involved are conserved, while the tissues responsible for these mechanisms are different in different species (Nakane and Yoshimura, Front Neurosci 8:115, 2014). It is well established that the circadian clock is involved in photoperiodic time measurement. However, the underlying mechanism that defines the photoinducible phase or critical photoperiod (i.e., how organisms measure day length using a circadian clock) is at the heart of photoperiodic time measurement, and this question remains to be answered by future studies.

DOI： 10.1007/978-81-322-3688-7_28

Scopus

Molecular and neuroendocrine mechanisms of avian seasonal reproduction

T. Katherine Tamai, Takashi Yoshimura

Advances in Experimental Medicine and Biology 1001 巻頁： 125 - 136 2017年

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Springer New York LLC

Animals living outside tropical zones experience seasonal changes in the environment and accordingly, adapt their physiology and behavior in reproduction, molting, and migration. Subtropical birds are excellent models for the study of seasonal reproduction because of their rapid and dramatic response to changes in photoperiod. For example, testicular weight typically changes by more than a 100-fold. In birds, the eyes are not necessary for seasonal reproduction, and light is instead perceived by deep brain photoreceptors. Functional genomic analysis has revealed that long day (LD)-induced thyrotropin from the pars tuberalis of the pituitary gland causes local thyroid hormone (TH) activation within the mediobasal hypothalamus. This local bioactive TH, triiodothyronine (T3), appears to regulate seasonal gonadotropin-releasing hormone (GnRH) secretion through morphological changes in neuro-glial interactions. GnRH, in turn, stimulates gonadotropin secretion and hence, gonadal development under LD conditions. In marked contrast, low temperatures accelerate short day (SD)-induced testicular regression in winter. Interestingly, low temperatures increase circulating levels of T3 to support adaptive thermogenesis, but this induction of T3 also triggers the apoptosis of germ cells by activating genes involved in metamorphosis. This apparent contradiction in the role of TH has recently been clarified. Central activation of TH during spring results in testicular growth, while peripheral activation of TH during winter regulates adaptive thermogenesis and testicular regression.

DOI： 10.1007/978-981-10-3975-1_8

Web of Science

Scopus

PubMed

The Hypothalamo-Pituitary-Thyroid (HPT)-axis: Animal Studies. (in press) 招待有り査読有り

Ikegami K, Yoshimura T

Best Practice & Research Clinical Endocrinology & Metabolism 2017年

組織特異的TSH糖鎖修飾招待有り査読有り

池上啓介, 吉村崇

月刊Mebio 33 巻頁： 11 - 18 2016年9月

Molecular basis for regulating seasonal reproduction in vertebrates 招待有り査読有り

Nishiwaki-Ohkawa Taeko, Yoshimura Takashi

JOURNAL OF ENDOCRINOLOGY 229 巻 ( 3 ) 頁： R117 - R127 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Endocrinology

Animals that inhabit mid-to high-latitude regions exhibit various adaptive behaviors, such as migration, reproduction, molting and hibernation in response to seasonal cues. These adaptive behaviors are tightly regulated by seasonal changes in photoperiod, the relative day length vs night length. Recently, the regulatory pathway of seasonal reproduction has been elucidated using quail. In birds, deep brain photoreceptors receive and transmit light information to the pars tuberalis in the pituitary gland, which induces the secretion of thyroid-stimulating hormone. Thyroid-stimulating hormone locally activates thyroid hormone via induction of type 2 deiodinase in the mediobasal hypothalamus. Thyroid hormone then induces morphological changes in the terminals of neurons that express gonadotropin-releasing hormone and facilitates gonadotropin secretion from the pituitary gland. In mammals, light information is received by photoreceptors in the retina and neurally transmitted to the pineal gland, where it inhibits the synthesis and secretion of melatonin, which is crucial for seasonal reproduction. Importantly, the signaling pathway downstream of light detection and signaling is fully conserved between mammals and birds. In fish, the regulatory components of seasonal reproduction are integrated, from light detection to neuroendocrine output, in a fish-specific organ called the saccus vasculosus. Various physiological processes in humans are also influenced by seasonal environmental changes. The findings discussed herein may provide clues to addressing human diseases, such as seasonal affective disorder.

DOI： 10.1530/JOE-16-0066

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Scopus

Comparative analysis reveals the underlying mechanism of vertebrate seasonal reproduction 査読有り国際誌

Ikegami Keisuke, Yoshimura Takashi

GENERAL AND COMPARATIVE ENDOCRINOLOGY 227 巻頁： 64 - 68 2016年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：General and Comparative Endocrinology

Animals utilize photoperiodic changes as a calendar to regulate seasonal reproduction. Birds have highly sophisticated photoperiodic mechanisms and functional genomics analysis in quail uncovered the signal transduction pathway regulating avian seasonal reproduction. Birds detect light with deep brain photoreceptors. Long day (LD) stimulus induces secretion of thyroid-stimulating hormone (TSH) from the pars tuberalis (PT) of the pituitary gland. PT-derived TSH locally activates thyroid hormone (TH) in the hypothalamus, which induces gonadotropin-releasing hormone (GnRH) and hence gonadotropin secretion. However, during winter, low temperatures increase serum TH for adaptive thermogenesis, which accelerates germ cell apoptosis by activating the genes involved in metamorphosis. Therefore, TH has a dual role in the regulation of seasonal reproduction. Studies using TSH receptor knockout mice confirmed the involvement of PT-derived TSH in mammalian seasonal reproduction. In addition, studies in mice revealed that the tissue-specific glycosylation of TSH diversifies its function in the circulation to avoid crosstalk. In contrast to birds and mammals, one of the molecular machineries necessary for the seasonal reproduction of fish are localized in the saccus vasculosus from the photoreceptor to the neuroendocrine output. Thus, comparative analysis is a powerful tool to uncover the universality and diversity of fundamental properties in various organisms.

DOI： 10.1016/j.ygcen.2015.05.009

Web of Science

Scopus

PubMed

Different Photoperiodic Responses in Four Lines of Japanese Quail 査読有り

Atsumi Yusuke, Yorinaga Eriko, Ota Wataru, Yoshimura Takashi

JOURNAL OF POULTRY SCIENCE 53 巻 ( 1 ) 頁： 63 - 66 2016年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本家禽学会

Organisms measure day length to better adapt to seasonal changes in the environment; this phenomenon is called photoperiodism. The Japanese quail has a highly sophisticated photoperiodic mechanism and is an excellent model for the study of photoperiodism. Various lines of quail have been established during the domestication process. In the present study, we examined the effect of long day (LD) followed by short day (SD) on testicular weight in four lines of quail (L, AMRP, NIES-Br, and WE). When the quail were raised under SD conditions, testicular development was suppressed in all examined lines. The speed of the LD-induced testicular development of NIES-Br line was faster than that of AMRP line, while the speed of the SD-induced testicular regression of L line was significantly faster than that of WE line. These quail lines provide excellent model to uncover the underlying mechanism of seasonal testicular regression.

DOI： 10.2141/jpsa.0150097

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Scopus

CiNii Books

その他リンク： https://jlc.jst.go.jp/DN/JLC/20019782070?from=CiNii

組織特異的TSH糖鎖修飾招待有り

池上啓介, 吉村崇

月間Mebio 33 巻頁： 11 - 18 2016年

なぜ動物は種特有の鳴き方ができるのか？ニワトリの「コケコッコー」を用いた先天的発声の研究招待有り

新村毅, 吉村崇

実験医学 34 巻頁： 618 - 621 2016年

春告げホルモンTSHが甲状腺を刺激しない仕組み招待有り

吉村崇

内分泌・糖尿病・代謝内科 42 巻頁： 58 - 62 2016年

脊椎動物の光周性制御機構招待有り

中根右介, 吉村崇

生体の科学 67 巻頁： 1 - 4 2016年

Lactic acid is a sperm motility inactivation factor in the sperm storage tubules

Matsuzaki Mei, Mizushima Shusei, Hiyama Gen, Hirohashi Noritaka, Shiba Kogiku, Inaba Kazuo, Suzuki Tomohiro, Dohra Hideo, Ohnishi Toshiyuki, Sato Yoshikatsu, Kohsaka Tetsuya, Ichikawa Yoshinobu, Atsumi Yusuke, Yoshimura Takashi, Sasanami Tomohiro

SCIENTIFIC REPORTS 5 巻 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Although successful fertilization depends on timely encounters between sperm and egg, the decoupling of mating and fertilization often confers reproductive advantages to internally fertilizing animals. In several vertebrate groups, postcopulatory sperm viability is prolonged by storage in specialized organs within the female reproductive tract. In birds, ejaculated sperm can be stored in a quiescent state within oviductal sperm storage tubules (SSTs), thereby retaining fertilizability for up to 15 weeks at body temperature (41 °C); however, the mechanism by which motile sperm become quiescent within SSTs is unknown. Here, we show that low oxygen and high lactic acid concentrations are established in quail SSTs. Flagellar quiescence was induced by lactic acid in the concentration range found in SSTs through flagellar dynein ATPase inactivation following cytoplasmic acidification (<pH 6.0). The long-term preservation of sperm morphology under hypoxic and high temperature conditions indicates that a combination of these factors enables sperm cells to survive during the ovulation cycles. Our findings suggested a novel physiological role for lactic acid in promoting sperm quiescence in SSTs and opened up a new opportunity for technological improvement in prolonging sperm longevity at ambient or body temperature.

DOI： 10.1038/srep17643

Web of Science

Scopus

Ontogeny of the Saccus Vasculosus, a Seasonal Sensor in Fish 査読有り

Maeda Ryosuke, Shimo Takayuki, Nakane Yusuke, Nakao Nobuhiro, Yoshimura Takashi

ENDOCRINOLOGY 156 巻 ( 11 ) 頁： 4238 - 4243 2015年11月

出版者・発行元：Endocrinology (United States)

TSH secreted from the pars distalis (PD) of the pituitary gland stimulates the thyroid gland. In contrast, TSH secreted from the pars tuberalis (PT) of the pituitary gland regulates seasonal reproduction. The ontogeny of thyrotrophs and the regulatory mechanisms of TSH are apparently different between the PD and the PT. Interestingly, fish do not have an anatomically distinct PT, and the saccus vasculosus (SV) of fish is suggested to act as a seasonal sensor. Thus, it is possible that the SV is analogous to the PT. Here we examined the ontogeny of the pituitary gland and SV using rainbow trout. A histological analysis demonstrated the development of the pituitary anlage followed by that of the SV. Lhx3 and Pit-1, which are required for the development of PD thyrotrophs, clearly labeled the pituitary anlage. The common glycoprotein β-subunit (CGA) and TSH β-subunit (TSHB) genes were also detected in the pituitary anlage. In contrast, none of these genes were detected in the SV anlage. We then performed a microarray analysis and identified parvalbumin (Pvalb) as a marker for SV development. Because Pvalb expression was not detected in the pituitary anlage, no relationship was observed between the development of the SV and the pituitary gland. In contrast to embryos, Lhx3, Pit-1, CGA, and TSHB were all expressed in the adult SV. These results suggest that the morphological differentiation of SV occurs during the embryonic stage but that the functional differentiation into a seasonal sensor occurs in a later developmental stage.

DOI： 10.1210/en.2015-1415

Web of Science

Scopus

PubMed

Disrupted seasonal biology impacts health, food security and ecosystems 査読有り国際共著

Stevenson T. J., Visser M. E., Arnold W., Barrett P., Biello S., Dawson A., Denlinger D. L., Dominoni D., Ebling F. J., Elton S., Evans N., Ferguson H. M., Foster R. G., Hau M., Haydon D. T., Hazlerigg D. G., Heideman P., Hopcraft J. G. C., Jonsson N. N., Kronfeld-Schor N., Kumar V., Lincoln G. A., MacLeod R., Martin S. A. M., Martinez-Bakker M., Nelson R. J., Reed T., Robinson J. E., Rock D., Schwartz W. J., Steffan-Dewenter I., Tauber E., Thackeray S. J., Umstatter C., Yoshimura T., Helm B.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 282 巻 ( 1817 ) 頁： 1817 2015年10月

出版者・発行元：Proceedings of the Royal Society B: Biological Sciences

The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and animals show profound annual cycles in physiology, health, morphology, behaviour and demography in response to environmental cues. Seasonal biology impacts ecosystems and agriculture, with consequences for humans and biodiversity. Human populations show robust annual rhythms in health and well-being, and the birth month can have lasting effects that persist throughout life. This review emphasizes the need for a better understanding of seasonal biology against the backdrop of its rapidly progressing disruption through climate change, human lifestyles and other anthropogenic impact. Climate change is modifying annual rhythms to which numerous organisms have adapted, with potential consequences for industries relating to health, ecosystems and food security. Disconcertingly, human lifestyles under artificial conditions of eternal summer provide the most extreme example for disconnect from natural seasons, making humans vulnerable to increased morbidity and mortality. In this review, we introduce scenarios of seasonal disruption, highlight key aspects of seasonal biology and summarize from biomedical, anthropological, veterinary, agricultural and environmental perspectives the recent evidence for seasonal desynchronization between environmental factors and internal rhythms. Because annual rhythms are pervasive across biological systems, they provide a common framework for transdisciplinary research.

DOI： 10.1098/rspb.2015.1453

Web of Science

Scopus

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