研究者詳細 - 吉村　崇

論文 - 吉村　崇

分割表示 214 件中 121 - 140 件目／全件表示 >>

Genetic and Molecular Analysis of Wild-Derived Arrhythmic Mice 査読有り

Watanabe Tsuyoshi, Suzuki Tohru, Ishikawa Akira, Yokota Yuki, Ueda Hiroki R., Yamada Rikuhiro G., Tei Hajime, Imai Saki, Tomida Shigeru, Kobayashi Junya, Naito Emiko, Yasuo Shinobu, Nakao Nobuhiro, Namikawa Takao, Yoshimura Takashi, Ebihara Shizufumi

PLOS ONE 4 巻 ( 1 ) 頁： e4301 2009年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

A new circadian variant was isolated by screening the intercross offspring of wild-caught mice (Mus musculus castaneus). This variant was characterized by an initial maintenance of damped oscillations and subsequent loss of rhythmicity after being transferred from light-dark (LD) cycles, to constant darkness (DD). To map the genes responsible for the persistence of rhythmicity (circadian ratio) and the length of free-running period (τ), quantitative trait locus (QTL) analysis was performed using F2 mice obtained from an F1 cross between the circadian variant and C57BL/6J mice. As a result, a significant QTL with a main effect for circadian ratio (Arrhythmicity; Arrh-1) was mapped on Chromosome (Chr) 8. For τ, four significant QTLs, Short free-running period (Sfp-1) (Chr 1), Sfp-2 (Chr 6), Sfp-3 (Chr 8), Sfp-4 (Chr 11) were determined. An epistatic interaction was detected between Chr 3 (Arrh-2) and Chr 5 (Arrh-3). An in situ hybridization study of clock genes and mouse Period 1::luciferase (mPer1::luc) real-time monitoring analysis in the suprachiasmatic nucleus (SCN) suggested that arrhythmicity in this variant might not be attributed to core circadian mechanisms in the SCN neurons. Our strategy using wild-derived variant mice may provide a novel opportunity to evaluate circadian and its related disorders in human that arise from the interaction between multiple variant genes. © 2009 Watanabe et al.

DOI： 10.1371/journal.pone.0004301

Web of Science

Scopus

PubMed

Identification of the photoperiodic signal transduction pathway regulating seasonal reproduction using the functional genomics approach. 招待有り査読有り

Ono H, Nakao N, Yoshimura T

General and Comparative Endocrinology 163 巻頁： 2-6 2009年

Molecular mechanism of seasonal time measurement in vertebrates

Yoshimura Takashi

NEUROSCIENCE RESEARCH 65 巻頁： S23 - S23 2009年

Localization of circadian clock protein in the photoperiodic signal transduction machinery

Ikegami Keisuke, Katou Yasuhiro, Higashi Kumiko, Yoshimura Takashi

NEUROSCIENCE RESEARCH 65 巻頁： S232 - S232 2009年

Effect of dorsal hypothalamic lesion on seasonal reproduction in Japanese quail

Nakane Yusuke, Higashi Kumiko, Iigo Masayuki, Ebihara Shizufumi, Yoshimura Takashi

NEUROSCIENCE RESEARCH 65 巻頁： S232 - S232 2009年

QTL analysis of behavioral despair in mice

Imai Saki, Tomida Shigeru, Yoshimura Takashi, Ebihara Shizufumi

GENES & GENETIC SYSTEMS 83 巻 ( 6 ) 頁： 491 - 491 2008年12月

Functional genomics of seasonal time measurement

Yoshimura Takashi

GENES & GENETIC SYSTEMS 83 巻 ( 6 ) 頁： 530 - 530 2008年12月

Identification of a quantitative trait gene underlying behavioral despair using CS mice with abnormal circadian rhythms

Ebihara Shizufumi, Tomida Shigeru, Mamiya Takayoshi, Sakamaki Hirotake, Kameyama Tsutomu, Nabeshima Toshitaka, Kobayashi Junya, Iwaki Yuka, Imai Saki, Ishikawa Akira, Abe Kuniya, Yoshimura Takashi

GENES & GENETIC SYSTEMS 83 巻 ( 6 ) 頁： 531 - 531 2008年12月

Involvement of thyrotropin in photoperiodic signal transduction in mice

Ono Hiroko, Hoshino Yuta, Yasuo Shinobu, Watanabe Miwa, Nakane Yusuke, Murai Atsushi, Ebihara Shizufumi, Korf Horst-Werner, Yoshimura Takashi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 巻 ( 47 ) 頁： 18238 - 18242 2008年11月

Thyroid hormones and seasonal reproductive neuroendocrine interactions

Nakao Nobuhiro, Ono Hiroko, Yoshimura Takashi

REPRODUCTION 136 巻 ( 1 ) 頁： 1 - 8 2008年7月

Reorganization of the suprachiasmatic nucleus by photic and non-photic environments 査読有り

Shizufumi Ebihara, Emiko Naito, Tsuyoshi Watanabe, Takashi Yoshimura

SLEEP AND BIOLOGICAL RHYTHMS 6 巻 ( 2 ) 頁： 62 - 66 2008年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BLACKWELL PUBLISHING

To better understand alterations in suprachiasmatic nucleus (SCN) physiology by photic and non-photic environments, we analyzed clock gene expression in the mouse SCN by in situ hybridization and real-time monitoring of mPerl::luc bioluminescence. An artificial light : dark : light : dark 7:5:7:S condition induced antiphase oscillation of the clock gene in the dorsomedial-like (DM-like) and the ventrolateral-like (VL-like) subdivisions of the SCN, in parallel with maintaining synchronization between the two sides of the SCN. This antiphase oscillation seems to be responsible for the bimodal rhythms of mPer1 bioluminescence observed in the entire SCN and the components of splitting locomotor activity. A long photoperiod (LP) induced the phase advance of the rhythms of clock gene expression in the caudal SCN relative to those in the rostral SCN. In addition, in the middle SCN, the rhythms of the VL-like subdivision phase-led those in the DM-like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited two peaks with a wide peak width under LP conditions. Imaging analysis of the mPerl::luc rhythms revealed wide regional variations in the peak time in the rostral half of the SCN. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. In CS mice which easily entrain to daily restricted feeding (RF) cycles, the peak width for mPer1::luc bioluminescence rhythms in the SCN markedly increased during the RF schedule under LID conditions. These data in CS mice suggest non-photic cues alter SCN organization and provided a new method to reveal subdivisional changes of the SCN by feeding cues.

DOI： 10.1111/j.1479-8425.2008.00345.x

Web of Science

Reorganization of the suprachiasmatic nucleus coding for day length 査読有り

Naito Emiko, Watanabe Tsuyoshi, Tei Hajime, Yoshimura Takashi, Ebihara Shizufumi

JOURNAL OF BIOLOGICAL RHYTHMS 23 巻 ( 2 ) 頁： 140 - 149 2008年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Biological Rhythms

In mammals, the suprachiasmatic nucleus (SCN), the circadian pacemaker, receives light information via the retina and functions in the entrainment of circadian rhythms and in phasing the seasonal responses of behavioral and physiological functions. To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod (LP) conditions, the expression rhythms of mPer1 and Bmal1 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)-like subdivision advanced compared with those in the dorsomedial (DM)-like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length. © 2008 Sage Publications.

DOI： 10.1177/0748730408314572

Web of Science

Scopus

PubMed

Thyrotrophin in the pars tuberalis triggers photoperiodic response

Nakao Nobuhiro, Ono Hiroko, Yamamura Takashi, Anraku Tsubasa, Takagi Tsuyoshi, Higashi Kumiko, Yasuo Shinobu, Katou Yasuhiro, Kageyama Saburo, Uno Yumiko, Kasukawa Takeya, Iigo Masayuki, Sharp Peter J., Iwasawa Atsushi, Suzuki Yutaka, Sugano Sumio, Niimi Teruyuki, Mizutani Makoto, Namikawa Takao, Ebihara Shizufumi, Ueda Hiroki R., Yoshimura Takashi

NATURE 452 巻 ( 7185 ) 頁： 317 - U1 2008年3月

春を告げる甲状腺刺激ホルモン招待有り

中尾暢宏、小野ひろ子、吉村崇

比較内分泌学 34 巻頁： 77-82 2008年

脊椎動物が春を感知するしくみをさぐる招待有り

吉村崇

蛋白質　核酸　酵素 53 巻頁： 1865-1872 2008年

鳥類の光周性の機能ゲノミクス招待有り

小野ひろ子、中尾暢宏、吉村崇

時間生物学 14 巻頁： 2-8 2008年

春を告げる甲状腺刺激ホルモン招待有り

中尾暢宏, 小野ひろ子, 吉村崇

比較内分泌学 34 巻頁： 77-82 2008年

Positional identification of a quantitative trait gene that controls "behavioral despair" in mice

Tomida Shigeru, Sakamaki Hirotake, Kobayashi Junya, Abe Kuniya, Kameyama Tsutomu, Mamiya Takayoshi, Ishikawa Akira, Yoshimura Takashi, Ebihara Shizufumi

NEUROSCIENCE RESEARCH 61 巻頁： S70 - S70 2008年

Molecular mechanisms of vertebrate photoperiodism

Ebihara Shizufumi, Yasuo Shinobu, Nakao Nobuhiro, Yoshimura Takashi

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 148 巻 ( 3 ) 頁： 338 - 338 2007年11月

Temporal dynamics of type 2 deiodinase expression after melatonin injections in Syrian hamsters

Yasuo Shinobu, Yoshimura Takashi, Ebihara Shizufumi, Korf Horst-Werner

ENDOCRINOLOGY 148 巻 ( 9 ) 頁： 4385 - 4392 2007年9月

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