研究者詳細 - 吉村　崇

論文 - 吉村　崇

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Animals' clever adaptation strategy for seasonal changes in environment

Ikegami Keisuke, Yoshimura Takashi

JAPANESE JOURNAL OF NEUROPSYCHOPHARMACOLOGY 35 巻 ( 4 ) 頁： 103 - 106 2015年8月

The highest-ranking rooster has priority to announce the break of dawn 査読有り

Shimmura Tsuyoshi, Ohashi Shosei, Yoshimura Takashi

SCIENTIFIC REPORTS 5 巻 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

The "cock-a-doodle-doo" crowing of roosters, which symbolizes the break of dawn in many cultures, is controlled by the circadian clock. When one rooster announces the break of dawn, others in the vicinity immediately follow. Chickens are highly social animals, and they develop a linear and fixed hierarchy in small groups. We found that when chickens were housed in small groups, the top-ranking rooster determined the timing of predawn crowing. Specifically, the top-ranking rooster always started to crow first, followed by its subordinates, in descending order of social rank. When the top-ranking rooster was physically removed from a group, the second-ranking rooster initiated crowing. The presence of a dominant rooster significantly reduced the number of predawn crows in subordinates. However, the number of crows induced by external stimuli was independent of social rank, confirming that subordinates have the ability to crow. Although the timing of subordinates' predawn crowing was strongly dependent on that of the top-ranking rooster, free-running periods of body temperature rhythms differed among individuals, and crowing rhythm did not entrain to a crowing sound stimulus. These results indicate that in a group situation, the top-ranking rooster has priority to announce the break of dawn, and that subordinate roosters are patient enough to wait for the top-ranking rooster's first crow every morning and thus compromise their circadian clock for social reasons.

DOI： 10.1038/srep11683

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C-H Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

Oshima Tsuyoshi, Yamanaka Iori, Kumar Anupriya, Yamaguchi Junichiro, Nishiwaki-Ohkawa Taeko, Muto Kei, Kawamura Rika, Hirota Tsuyoshi, Yagita Kazuhiro, Irle Stephan, Kay Steve A., Yoshimura Takashi, Itami Kenichiro

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54 巻 ( 24 ) 頁： 7193 - 7197 2015年6月

Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression

Ikegami Keisuke, Atsumi Yusuke, Yorinaga Eriko, Ono Hiroko, Murayama Itaru, Nakane Yusuke, Ota Wataru, Arai Natsumi, Tega Akinori, Iigo Masayuki, Darras Veerle M., Tsutsui Kazuyoshi, Hayashi Yoshitaka, Yoshida Shosei, Yoshimura Takashi

ENDOCRINOLOGY 156 巻 ( 2 ) 頁： 647 - 659 2015年2月

A unique mechanism of successful fertilization in a domestic bird

Sasanami Tomohiro, Izumi Shunsuke, Sakurai Naoki, Hirata Toshifumi, Mizushima Shusei, Matsuzaki Mei, Hiyama Gen, Yorinaga Eriko, Yoshimura Takashi, Ukena Kazuyoshi, Tsutsui Kazuyoshi

SCIENTIFIC REPORTS 5 巻 2015年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Fertilization is an indispensable step for formation of a zygote in sexual reproduction, leading to species survival. When mating occurs, sperm is transported to the female reproductive tracts via the seminal plasma (SP). SP is derived from male accessory sex glands and it plays pivotal roles for fertilization in animals. However, molecular mechanisms of SP or a fluid derived from male accessory sex glands for successful fertilization remain unclear. Here, we report that in male quail the cloacal gland (CG) produces prostaglandin F 2α (PGF 2α) that contributes to successful fertilization. PGF 2α, as well as the secretion of CG (CGS), induced vaginal contractions and caused the opening of the entrance of the sperm storage tubules, the structures responsible for the long-term sperm storage and fertilization. The removal of CGS from the male before mating reduced the fertility, but the supplementation of CGS or PGF 2α rescued the subfertility. We further showed that male CG contains glucose that is utilized as energy source for the intrinsic sperm mobility after transportation to female vagina. This mechanism, in concert with the excitatory effects of PGF 2α enables successful fertilization in the domestic bird.

DOI： 10.1038/srep07700

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季節感知機構の解析から見えてきた動物の巧みな戦略招待有り査読有り

池上啓介, 吉村崇

日本神経精神薬理学雑誌 35 巻 ( 4 ) 頁： 103 - 106 2015年

ホルモンの糖鎖修飾による巧みな生理機能の分担戦略招待有り査読有り

池上啓介, 吉村崇

日本比較内分泌学会 41 巻 ( 156 ) 頁： 127 - 128 2015年

Circannual Cycles and Photoperiodism

Cassone Vincent M., Yoshimura Takashi

STURKIE'S AVIAN PHYSIOLOGY, 6TH EDITION 頁： 829 - 845 2015年

季節感知機構の解析から見えてきた動物の巧みな戦略招待有り

池上啓介, 吉村崇

日本神経精神薬理学雑誌 35 巻頁： 103 - 106 2015年

触媒で体内時計のリズムを変える－異分野融合がもたらした新分子の発見招待有り

伊丹健一郎, 吉村崇

月刊化学 70 巻頁： 32 - 36 2015年

ホルモンの糖鎖修飾による巧みな生理機能の分担戦略招待有り

池上啓介, 吉村崇

比較内分泌学 41 巻頁： 129 - 130 2015年

Takashi Yoshimura

Yoshimura Takashi

CURRENT BIOLOGY 24 巻 ( 23 ) 頁： R1108 - R1109 2014年12月

Tissue-specific post-translational modification allows functional targeting of thyrotropin 査読有り

Ikegami K, Liao XH, Hoshino Y, Ono H, Ota W, Ito Y, Nishiwaki-Ohkawa T, Sato C, Kitajima K, Iigo M, Shigeyoshi Y, Yamada M, Murata Y, Refetoff S, Yoshimura T

Cell Reports 9 巻頁： 801-809 2014年11月

Thyrotoropin receptor knockout changes monoaminergic neuronal system and produces methylphenidate-sensitive emotional and cognitive dysfunction 査読有り国際誌

Mouri Akihiro, Hoshino Yuta, Narusawa Shiho, Ikegami Keisuke, Mizoguchi Hiroyuki, Murata Yoshiharu, Yoshimura Takashi, Nabeshima Toshitaka

PSYCHONEUROENDOCRINOLOGY 48 巻頁： 147 - 161 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Psychoneuroendocrinology

Attention deficit/hyperactivity disorder (ADHD) has been reported in association with resistance to thyroid hormone, a disease caused by a mutation in the thyroid hormone receptor β (TRβ) gene. TRβ is a key protein mediating down-regulation of thyrotropin (TSH) expression by 3,3',5-tri-iodothyronine (T3), an active form of thyroid hormone. Dysregulation of TSH and its receptor (TSHR) is implicated in the pathophysiology of ADHD but the role of TSHR remains elusive. Here, we clarified a novel role for TSHR in emotional and cognitive functions related to monoaminergic nervous systems. TSHR knockout mice showed phenotypes of ADHD such as hyperactivity, impulsiveness, a decrease in sociality and increase in aggression, and an impairment of short-term memory and object recognition memory. Administration of methylphenidate (1, 5 and 10. mg/kg) reversed impulsiveness, aggression and object recognition memory impairment. In the knockout mice, monoaminergic changes including decrease in the ratio of 3-methoxy-4-hydroxyphenylglycol/noradrenaline and increase in the ratio of homovanillic acid/dopamine were observed in some brain regions, accompanied by increase in the expression of noradrenaline transporter in the frontal cortex. When TSH was completely suppressed by the supraphysiological administration of T3 to the adult mice, some behavioral and neurological changes in TSHR KO mice were also observed, suggesting that these changes were not due to developmental hypothyroidism induced by the inactivation of TSHR but to the loss of the TSH-TSHR pathway itself. Taken together, the present findings suggest a novel role for TSHR in behavioral and neurological phenotypes of ADHD. © 2014 Elsevier Ltd.

DOI： 10.1016/j.psyneuen.2014.05.021

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PubMed

Intrinsic photosensitivity of a deep brain photoreceptor

Nakane Yusuke, Shimmura Tsuyoshi, Abe Hideki, Yoshimura Takashi

CURRENT BIOLOGY 24 巻 ( 13 ) 頁： R596 - R597 2014年7月

記述言語：英語出版者・発行元：Current Biology

In addition to having a photoreceptive retina and pineal organ, non-mammalian vertebrates are known to have photoreceptors in the deeper regions of the brain that mediate seasonal changes in physiology and behavior [1]. Cerebrospinal fluid (CSF)-contacting neurons extend knob-like dendrites into the ventricular cavity, where they form ciliated terminals [2]. The dendritic structures of photoreceptor cells in the developing retina and the pineal organ resemble those of CSF-contacting neurons. Thus, CSF-contacting neurons have been suggested to function as deep brain photoreceptors. Although the localization of a novel short-wavelength-sensitive photopigment (OPN5) that detects violet and ultraviolet (UV) light has been recently demonstrated in CSF-contacting neurons [3,4], there has been no direct evidence of photosensitivity in deep brain CSF-contacting neurons. Here, we report that the OPN5-positive CSF-contacting neurons in the paraventricular organ (PVO) of the quail mediobasal hypothalamus (MBH) are intrinsically photosensitive and are involved in the regulation of seasonal reproduction. © 2014 Elsevier Ltd.

DOI： 10.1016/j.cub.2014.05.038

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Universality and diversity in the signal transduction pathway that regulates seasonal reproduction in vertebrates 招待有り査読有り

Nakane Yusuke, Yoshimura Takashi

FRONTIERS IN NEUROSCIENCE 8 巻 ( 8 MAY ) 頁： 115 2014年5月

記述言語：英語出版者・発行元：Frontiers in Neuroscience

Most vertebrates living outside the tropical zone show robust physiological responses in response to seasonal changes in photoperiod, such as seasonal reproduction, molt, and migration. The highly sophisticated photoperiodic mechanism in Japanese quail has been used to uncover the mechanism of seasonal reproduction. Molecular analysis of quail mediobasal hypothalamus (MBH) revealed that local thyroid hormone activation within the MBH plays a critical role in the photoperiodic response of gonads. This activation is accomplished by two gene switches: thyroid hormone-activating (DIO2) and thyroid hormone-inactivating enzymes (DIO3). Functional genomics studies have shown that long-day induced thyroid-stimulating hormone (TSH) in the pars tuberalis (PT) of the pituitary gland regulates DIO2/3 switching. In birds, light information received directly by deep brain photoreceptors regulates PT TSH. Recent studies demonstrated that Opsin 5-positive cerebrospinal fluid (CSF)-contacting neurons are deep brain photoreceptors that regulate avian seasonal reproduction. Although the involvement of TSH and DIO2/3 in seasonal reproduction has been confirmed in various mammals, the light input pathway that regulates PT TSH in mammals differs from that of birds. In mammals, the eye is the only photoreceptor organ and light information received by the eye is transmitted to the pineal gland through the circadian pacemaker, the suprachiasmatic nucleus. Nocturnal melatonin secretion from the pineal gland indicates the length of night and regulates the PT TSH. In fish, the regulatory machinery for seasonal reproduction, from light input to neuroendocrine output, has been recently demonstrated in the coronet cells of the saccus vasculosus (SV). The SV is unique to fish and coronet cells are CSF-contacting neurons. Here, we discuss the universality and diversity of signal transduction pathways that regulate vertebrate seasonal reproduction. © 2014 Nakane and Yoshimura.

DOI： 10.3389/fnins.2014.00115

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Sperm activation by heat shock protein 70 supports the migration of sperm released from sperm storage tubules in Japanese quail (<i>Coturnix japonica</i>) 査読有り国際誌

Hiyama Gen, Matsuzaki Mei, Mizushima Shusei, Dohra Hideo, Ikegami Keisuke, Yoshimura Takashi, Shiba Kogiku, Inaba Kazuo, Sasanami Tomohiro

REPRODUCTION 147 巻 ( 2 ) 頁： 167 - 178 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Reproduction

Systems for maintaining the viability of ejaculated sperm in the female reproductive tract are widespread among vertebrates and invertebrates. In birds, this sperm storage function is performed by specialized simple tubular invaginations called sperm storage tubules (SSTs) in the uterovaginal junction (UVJ) of the oviduct. Although the incidence and physiological reasons for sperm storage in birds have been reported extensively, the mechanisms of sperm uptake by the SSTs, sperm maintenance within the SSTs, and control of sperm release from the SSTs are poorly understood. In this study, we demonstrated that the highly conserved heat shock protein 70 (HSP70) stimulates sperm motility in vitro and also that HSP70 expressed in the UVJ may facilitate the migration of sperm released from the SSTs. Quantitative RT-PCR analysis demonstrated that the expression of HSP70 mRNA in the UVJ increases before ovulation/oviposition. Gene-specific in situ hybridization and immunohistochemical analysis with a specific antibody to HSP70 demonstrated that HSP70 is localized in the surface epithelium of the UVJ. Furthermore, injection of anti-HSP70 antibody into the vagina significantly inhibited fertilization in vivo. In addition, we found that recombinant HSP70 activates flagellar movement in the sperm and that the binding of recombinant HSP70 to the sperm surface is mediated through an interaction with voltage-dependent anion channel protein 2 (VDAC2). Our results suggest that HSP70 binds to the sperm surface by interacting with VDAC2 and activating sperm motility. This binding appears to play an important role in sperm migration within the oviduct. © 2014 Society for Reproduction and Fertility.

DOI： 10.1530/REP-13-0439

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PubMed

魚類の季節センサー Seasonal sensor in fish

中根右介, 池上啓介, 飯郷雅之, 吉村崇

比較内分泌学 40 巻 ( 152 ) 頁： 65 - 67 2014年

Regulation of seasonal reproduction by hypothalamic activation of thyroid hormone 査読有り国際誌

Shinomiya Ai, Shimmura Tsuyoshi, Nishiwaki-Ohkawa Taeko, Yoshimura Takashi

FRONTIERS IN ENDOCRINOLOGY 5 巻 ( FEB ) 頁： 12 - 12 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Endocrinology

Organisms living outside the tropics measure the changes in the length of the day to adapt to seasonal changes in the environment. Animals that breed during spring and summer are called long-day breeders, while those that breed during fall are called short-day breeders. Although the influence of thyroid hormone in the regulation of seasonal reproduction has been known for several decades, its precise mechanism remained unknown. Recent studies revealed that the activation of thyroid hormone within the mediobasal hypothalamus plays a key role in this phenomenon. This localized activation of the thyroid hormone is controlled by thyrotropin (thyroid-stimulating hormone) secreted from the pars tuberalis of the pituitary gland. Although seasonal reproduction is a rate-limiting factor in animal production, genes involved in photoperiodic signal transduction pathway could emerge as potential targets to facilitate domestication. © 2014 Shinomiya, Shimmura, Nishiwaki-Ohkawa and Yoshimura.

DOI： 10.3389/fendo.2014.00012

Web of Science

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PubMed

季節リズムの制御メカニズム招待有り

大川妙子, 吉村崇

睡眠医療 8 巻頁： 203 - 209 2014年

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