Faculty Profiles - TANAKA Akihito

Papers - TANAKA Akihito

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Coronary air embolism following transbronchial lung biopsy. Reviewed

Sumi T, Tanaka A, Ishii H, Suzuki S, Kada K, Murohara T

Cardiovascular intervention and therapeutics Vol. 34 ( 1 ) page： 64 - 66 2019.1

Impact of Nutritional and Inflammation Status on Long-Term Bleeding in Patients Undergoing Percutaneous Coronary Intervention with an Oral Anticoagulant. Reviewed

Yoshida R, Ishii H, Morishima I, Tanaka A, Morita Y, Takagi K, Yoshioka N, Hirayama K, Iwakawa N, Tashiro H, Kojima H, Mitsuda T, Hitora Y, Furusawa K, Tsuboi H, Murohara T

Journal of atherosclerosis and thrombosis Vol. 26 ( 8 ) page： 728 - 737 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

Aim: Patients undergoing percutaneous coronary intervention (PCI) who require both oral anticoagulant (OAC) and antiplatelet therapy (APT) are exposed to a serious risk of bleeding. The aim of this study was to clarify the relationship among nutritional and inflammation status and long-term bleeding in patients requiring both OACs and APT after PCI.Methods: We performed PCI in 3,718 consecutive patients between April 2011 and March 2017, 302 of whom were treated with both OACs and APT. Patients were followed for up to 3 years for bleeding events, defined as the Bleeding Academic Research Consortium (BARC) class ≥3 bleeding. We retrospectively evaluated the ability of the Geriatric Nutritional Risk Index (GNRI) and high-sensitivity C-reactive protein (hs-CRP) to detect bleeding events.Results: During a median follow-up of 1,080 days, bleeding events were observed in 53 (17.5%) patients. Bleeding events were associated with a low GNRI (≤98) (hazard ratio [HR], 3.16; 95% confidence interval [CI], 1.84-5.45; p＜0.0001) and hs-CRP level ≥2.5 mg/L (HR, 2.75; 95% CI, 1.61-4.78; p=0.0003). A low GNRI＋high hs-CRP showed a 5.12-fold increase in the incidence of BARC class ≥3 bleeding (95% CI, 2.68-9.91; p＜0.0001) compared with a normal GNRI＋low hs-CRP. The addition of the GNRI and hs-CRP to the PRECISE-DAPT score improved C-statistics from 0.67 to 0.71 and enhanced the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) (NRI, 0.36, p＜0.0001; IDI, 0.066, p＜0.0001).Conclusions: The GNRI and hs-CRP were novel predictors of the long-term bleeding risk in patients requiring both OACs and APT after PCI.

DOI： 10.5551/jat.47654

Early versus delayed invasive strategy in patients with non-ST-elevation acute coronary syndrome and concomitant congestive heart failure Reviewed

Yoshida, R., Ishii, H., Morishima, I., Tanaka, A., Morita, Y., Takagi, K., Yoshioka, N., Hirayama, K., Iwakawa, N., Tashiro, H., Kojima, H., Mitsuda, T., Hitora, Y., Furusawa, K., Tsuboi, H., Murohara, T.

Journal of Cardiology Vol. 74 ( 3-4 ) page： 320 - 327 2019

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

Kimura, K., Kimura, T., Ishihara, M., Nakagawa, Y., Nakao, K., Miyauchi, K., Sakamoto, T., Tsujita, K., Hagiwara, N., Miyazaki, S., Ako, J., Arai, H., Ishii, H., Origuchi, H., Shimizu, W., Takemura, H., Tahara, Y., Morino, Y., Iino, K., Itoh, T., Iwanaga, Y., Uchida, K., Endo, H., Kongoji, K., Sakamoto, K., Shiomi, H., Shimohama, T., Suzuki, A., Takahashi, J., Takeuchi, I., Tanaka, A., Tamura, T., Nakashima, T., Noguchi, T., Fukamachi, D., Mizuno, T., Yamaguchi, J., Yodogawa, K., Kosuge, M., Kohsaka, S., Yoshino, H., Yasuda, S., Shimokawa, H., Hirayama, A., Akasaka, T., Haze, K., Ogawa, H., Tsutsui, H., Yamazaki, T.

Circulation Journal Vol. 83 ( 5 ) page： 1085 - 1196 2019

Myocardial salvage after ST-segment-elevation myocardial infarction: comparison between prasugrel and clopidogrel in the presence or absence of high-residual platelet reactivity Reviewed

Yoshida, R., Takagi, K., Ishii, H., Morishima, I., Tanaka, A., Morita, Y., Kanzaki, Y., Nagai, H., Watanabe, N., Furui, K., Shibata, N., Yoshioka, N., Yamauchi, R., Komeyama, S., Sugiyama, H., Tsuboi, H., Murohara, T.

Journal of Nuclear Cardiology Vol. 28 ( 4 ) page： 1422 - 1434 2019

Incidence, Technical Safety, and Feasibility of Coronary Angiography and Intervention Following Self-expanding Transcatheter Aortic Valve Replacement Reviewed

Tanaka, A., Jabbour, R.J., Testa, L., Agnifili, M., Ettori, F., Fiorina, C., Adamo, M., Bruschi, G., Giannini, C., Petronio, A.S., Barbanti, M., Tamburino, C., De Felice, F., Reimers, B., Poli, A., Colombo, A., Latib, A.

Cardiovascular Revascularization Medicine Vol. 20 ( 5 ) page： 371 - 375 2019

A survival case of a young adult patient with ST-elevated myocardial infarction with high levels of lipoprotein(a)

Hiraiwa, H., Morimoto, R., Okumura, T., Arao, Y., Oishi, H., Kato, H., Yamaguchi, S., Kuwayama, T., Haga, T., Yokoi, T., Kondo, T., Watanabe, N., Mitsuda, T., Fukaya, K., Sawamura, A., Tanaka, A., Ishii, H., Morishima, I., Tsuboi, H., Murohara, T.

Journal of Cardiology Cases Vol. 19 ( 6 ) page： 207 - 210 2019

New-generation drug-eluting stents for left main coronary artery disease according to the EXCEL trial enrollment criteria: Insights from the all-comers, international, multicenter DELTA-2 registry. Reviewed International coauthorship

Tanaka A, Giustino G, Briede I, Sawaya FJ, Daemen J, Kawamoto H, Meliga E, D'Ascenzo F, Cerrato E, Stefanini GG, Capodanno D, Mangiameli A, Templin C, Erglis A, Morice MC, Mehran R, Van Mieghem NM, Nakamura S, De Benedictis M, Pavani M, Varbella F, Pisaniello M, Sharma SK, Tamburino C, Tchetche D, Colombo A, Chieffo A, DELTA, Investigators

International journal of cardiology Vol. 280 page： 30 - 37 2018.12

New-Generation Drug-Eluting Stents for Left Main In-Stent Restenosis: The DELTA-2 Registry Reviewed International coauthorship

Giustino, G., Tanaka, A., Erglis, A., Morice, M.C., Van Mieghem, N.M., Meliga, E., D'Ascenzo, F., Stefanini, G.G., Capodanno, D., Chieffo, A.

JACC: Cardiovascular Interventions Vol. 11 ( 23 ) page： 2438-2440 - 2440 2018.12

Long-term follow-up of BVS from a prospective multicenter registry: Impact of a dedicated implantation technique on clinical outcomes. Reviewed

Regazzoli D, Latib A, Ezhumalai B, Tanaka A, Leone PP, Khan S, Kumar V, Rastogi V, Ancona MB, Mangieri A, Giannini F, Mitomo S, Seth A, Colombo A

International journal of cardiology Vol. 270 page： 113-117 - 117 2018.11

Vasospastic angina in a 16-year-old female. Reviewed

Sumi T, Tanaka A, Ishii H, Suzuki S, Oguri M, Murohara T

Cardiovascular intervention and therapeutics Vol. 33 ( 4 ) page： 393 - 394 2018.10

Clinical Impact of Circulating Irisin on Classified Coronary Plaque Characteristics

Hirayama Kenshi, Ishii Hideki, Kikuchi Ryosuke, Suzuki Susumu, Aoki Toshijiro, Harada Kazuhiro, Sumi Takuya, Negishi Yosuke, Shibata Yohei, Tatami Yosuke, Tanaka Akihito, Murohara Toyoaki

JOURNAL OF APPLIED LABORATORY MEDICINE Vol. 3 ( 1 ) page： 79 - 88 2018.7

Language：Japanese Publisher：The journal of applied laboratory medicine

BACKGROUND: Myokines are hormones secreted by skeletal muscles during physical activity. Low myokine levels may contribute to metabolic dysfunction and cardiovascular disorders. Irisin, a newly identified myokine, has been the focus of recent research. The aim of the present study was to analyze the association between circulating irisin levels and tissue characteristics of nonculprit left main coronary artery (LMCA) plaques with the use of integrated backscatter (IB) intravascular ultrasound (IVUS). METHODS: This observational study enrolled 55 Japanese patients following successful percutaneous coronary intervention for lesions in the left anterior descending arteries or left circumflex arteries. Circulating myokine levels, including myostatin, brain-derived neurotrophic factor, and irisin, were measured by an enzyme-linked immunosorbent assay. Tissue characteristics of LMCA plaque were evaluated by IB-IVUS. RESULTS: Circulating irisin levels were negatively associated with percent lipid volume (%LV) [r = -0.31 (95% CI, -2.52 to -0.21), P = 0.02] and positively associated with percent fibrous volume (%FV) [r = 0.32 (95% CI, 0.22-2.20), P = 0.02]. The optimal cutoff value of circulating irisin for the prediction of lipid-rich LMCA plaques was 6.02 μg/mL [area under the curve = 0.713, P < 0.01 (95% CI, 0.58-0.85)]. Multivariate linear regression analysis identified circulating irisin levels as independent predictors for %LV and %FV of the LMCA [β = -0.29 (95% CI, -2.53 to -0.07), P = 0.04 and β = 0.30 (95% CI, 0.10-2.23), P = 0.03, respectively]. CONCLUSIONS: Circulating irisin levels are significantly associated with tissue characteristics of nonculprit LMCA plaques.

DOI： 10.1373/jalm.2017.025296

Association between the ratio of anti-angiogenic isoform of VEGF-A to total VEGF-A and adverse clinical outcomes in patients after acute myocardial infarction

Harada Kazuhiro, Kikuchi Ryosuke, Ishii Hideki, Shibata Yohei, Suzuki Susumu, Tanaka Akihito, Suzuki Atsuo, Hirayama Kenshi, Murohara Toyoaki

IJC HEART & VASCULATURE Vol. 19 page： 3 - 7 2018.6

Impact of high-density lipoprotein 3 cholesterol subfraction on periprocedural myocardial injury in patients who underwent elective percutaneous coronary intervention

Harada Kazuhiro, Kikuchi Ryosuke, Suzuki Susumu, Tanaka Akihito, Aoki Toshijiro, Iwakawa Naoki, Kojima Hiroki, Hirayama Kenshi, Mitsuda Takayuki, Sumi Takuya, Negishi Yosuke, Ishii Hideki, Murohara Toyoaki

LIPIDS IN HEALTH AND DISEASE Vol. 17 ( 1 ) page： 21 2018.2

Comparison of mid-term clinical outcomes after treatment of ostial right coronary artery lesions with early and new generation drug-eluting stents: Insights from an international multicenter registry Reviewed

Mitomo, S., Jabbour, R.J., Watanabe, Y., Mangieri, A., Ancona, M., Regazzoli, D., Tanaka, A., Nakajima, A., Naganuma, T., Giannini, F., Latib, A., Nakamura, S., Colombo, A.

International Journal of Cardiology Vol. 254 page： 53 - 58 2018

Impact of post-dilatation on longitudinal stent elongation: An in vitro study.

Sumi T, Ishii H, Tanaka A, Suzuki S, Kojima H, Iwakawa N, Aoki T, Hirayama K, Mitsuda T, Harada K, Negishi Y, Ota T, Kada K, Murohara T

Journal of cardiology Vol. 71 ( 5-6 ) page： 464 - 470 2018

Different behavior of bioresorbable vascular scaffold and metallic stent with positive vessel remodeling Reviewed

Mitomo, S., Regazzoli, D., Candilio, L., Tanaka, A., Latib, A., Colombo, A.

Circulation Journal Vol. 82 ( 6 ) page： 1716 - 1717 2018

A comparison of the fully repositionable and retrievable Boston Lotus and direct flow medical valves for the treatment of severe aortic stenosis: A single center experience Reviewed

Giannini, F., Latib, A., Montorfano, M., Ruparelia, N., Romano, V., Longoni, M., Ferri, L., Jabbour, R., Mangieri, A., Regazzoli, D., Ancona, M., Buzzatti, N., Azzalini, L., Tanaka, A., Agricola, E., Chieffo, A., Alfieri, O., Colombo, A.

Catheterization and Cardiovascular Interventions Vol. 91 ( 5 ) page： 966 - 974 2018

Bioresorbable vascular scaffold versus everolimus-eluting stents or drug eluting balloon for the treatment of coronary in-stent restenosis: 1-Year follow-up of a propensity score matching comparison (the BIORESOLVE-ISR Study) Reviewed

Moscarella, E., Tanaka, A., Ielasi, A., Cortese, B., Coscarelli, S., De Angelis, M.C., Piraino, D., Latib, A., Grigis, G., Bianchi, R., Buccheri, D., Calabrò, P., Tespili, M., Silva Orrego, P., Colombo, A., Varricchio, A.

Catheterization and Cardiovascular Interventions Vol. 92 ( 4 ) page： 668 - 677 2018

“Golden tube” with favorable vessel remodeling at four-year follow-up after bioresorbable vascular scaffold implantation for moderate to severe calcified lesions: Insights from intravascular imaging

Mitomo, S., Candilio, L., Tanaka, A., Latib, A., Colombo, A.

Cardiology Journal Vol. 25 ( 4 ) page： 532 - 533 2018

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Papers - TANAKA Akihito