Faculty Profiles - TANAKA Akihito

Papers - TANAKA Akihito

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Impact of diabetes mellitus on the aortic wall changes as atherosclerosis progresses: Aortic dilatation and calcification Reviewed

Iwakawa, N., Tanaka, A., Ishii, H., Kataoka, T., Niwa, K., Hitora, Y., Tashiro, H., Mitsuda, T., Kojima, H., Hirayama, K., Furusawa, K., Yoshida, R., Suzuki, S., Murohara, T.

Journal of Atherosclerosis and Thrombosis Vol. 27 ( 6 ) page： 509 - 515 2020

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society

Aim: An inverse association between diabetes mellitus (DM) and aortic dilatation has recently been reported. However, little is known about the association between DM and the progression of aortic dilatation/calcification as atherosclerosis progresses. Methods: We identified 216 patients who had undergone percutaneous coronary intervention (PCI) and abdominal computed tomography (CT) during the PCI and follow-up phases. The patients were classified into two groups: those with DM (DM+ group; n=107) and those without DM (DM− group; n=109). The infrarenal aortic diameter and aortic calcification index (ACI) were measured, and annual changes were calculated using measurement results obtained during the PCI and follow-up phases. Results: Infrarenal aortic diameters were significantly shorter in the DM+ group than in the DM- group during the PCI phase, and no significant ACI differences were observed between the DM+ and DM− groups. The median duration between the PCI and follow-up phase CT was 3.0 years. The growth rate of the infrarenal aortic dilatation from the PCI phase in the DM+ group was similar to that in the DM− group. Annual ACI changes were significantly larger in the DM+ group than in the DM− group. Multivariate logistic regression analysis indicated that the prevalence of DM was an independent predictor of rapid aortic calcification progression (odds ratio: 2.51; 95% confidence interval: 1.23-5.14; p=0.01). Conclusion: Our findings suggest that DM negatively affects aortic dilatation during an earlier phase of atherosclerosis progression and positively affects the progression of aortic calcification in a later phase.

DOI： 10.5551/jat.50930

Reduced exercise capacity and clinical outcomes following acute myocardial infarction

Tashiro H., Tanaka A., Ishii H., Motomura N., Arai K., Adachi T., Okajima T., Hitora Y., Hayashi M., Furusawa K., Imai H., Ogawa Y., Kawaguchi K., Murohara T.

EUROPEAN HEART JOURNAL Vol. 40 page： 2813 - 2813 2019.10

Accumulative impact of poor nutrition and frailty on 1-year mortality among acute decompensated heart failure patients

Sumi T., Oguri M., Takahara K., Umemoto N., Shimizu K., Tanaka A., Ishii H., Murohara T.

EUROPEAN HEART JOURNAL Vol. 40 page： 1490 - 1490 2019.10

Accuracy and Safety of Newly Developed Optical-based FFR Device Compared to Conventional FFR Device

Suzuki Akihiro, Takashima Hiroaki, Saka Yuki, Waseda Katsuhisa, Ando Hirohiko, Nakano Yusuke, Sakurai Shinichiro, Fujimoto Masanobu, Ohashi Hirofumi, Tanaka Akihito, Ishii Hideki, Amano Tetsuya

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 73 ( 15 ) page： S68 - S68 2019.4

Saphenous Vein Graft Aneurysm 10 Years After Paclitaxel-Eluting Stent Implantation. Reviewed

Tanaka A, Jabbour RJ, Giannini F, Latib A, Colombo A

The Journal of invasive cardiology Vol. 29 ( 5 ) page： E63 2017.5

A Comparison Between First-Generation and Second-Generation Transcatheter Aortic Valve Implantation (TAVI) Devices: A Propensity-Matched Single-Center Experience. Reviewed International journal

Ruparelia N, Latib A, Kawamoto H, Buzzatti N, Giannini F, Figini F, Mangieri A, Regazzoli D, Stella S, Sticchi A, Tanaka A, Ancona M, Agricola E, Monaco F, Spagnolo P, Chieffo A, Montorfano M, Alfieri O, Colombo A

Journal of Invasive Cardiology Vol. 28 ( 5 ) page： 210 - 6 2016.5

Influence of the false lumen status on acute type A aortic dissection without urgent surgical repair

Tanaka A., Ishii H., Suzuki S., Ota T., Oshima H., Usui A., Murohara T.

EUROPEAN HEART JOURNAL Vol. 36 page： 1161 - 1161 2015.8

Association of estimated glomerular filtration rate and proteinuria with lipid-rich plaque in coronary artery disease Reviewed

Shimbo, Y., Suzuki, S., Ishii, H., Shibata, Y., Tatami, Y., Harata, S., Osugi, N., Ota, T., Tanaka, A., Shibata, K., Mizukoshi, T., Yasuda, Y., Maruyama, S., Murohara, T.

Circulation Journal Vol. 79 ( 10 ) page： 2263 - 2270 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:Estimated glomerular filtration rate (eGFR) and proteinuria are both important determinants of the risk of cardiovascular disease and mortality. The aim of the present study was to investigate the independent and combined effects of eGFR and proteinuria on tissue characterization of the coronary plaques of culprit lesions.Methods and Results:Conventional intravascular ultrasound and 3-D integrated backscatter intravascular ultrasound (IB-IVUS) were performed in 555 patients undergoing elective percutaneous coronary intervention. They were divided into 2 groups according to the absence or presence of proteinuria (dipstick result ≥1+). Patients with proteinuria had coronary plaque with significantly greater percentage lipid volume compared with those without (43.6±14.8% vs. 48.6±16.1%, P=0.005). Combined analysis was done using eGFR and absence or presence of proteinuria. Subjects with eGFR 45–59 ml/min/1.73 m2and proteinuria were significantly more likely to have higher percent lipid volume compared with those with eGFR >60 ml/min/1.73 m2without proteinuria. After multivariate adjustment for confounders, the presence of proteinuria proved to be an independent predictor for lipid-rich plaque (OR, 1.85; 95% CI: 1.12–3.06, P=0.016).Conclusions:The addition of proteinuria to eGFR level may be of value in the risk stratification of patients with coronary artery disease. (Circ J 2015; 79: 2263–2270)

DOI： 10.1253/circj.CJ-15-0460

Impact of airflow limitation on carotid atherosclerosis in coronary artery disease patients Reviewed

Hamrah, M.S., Suzuki, S., Ishii, H., Shibata, Y., Tatami, Y., Osugi, N., Ota, T., Kawamura, Y., Tanaka, A., Aso, H., Takeshita, K., Sakamoto, J., Hasegawa, Y., Murohara, T.

Respiration Vol. 89 ( 4 ) page： 322 - 328 2015

Assessment of in-stent restenosis using high-definition computed tomography with a new gemstone detector Reviewed International journal

Tsuda, T., Ishii, H., Ichimiya, S., Kanashiro, M., Watanabe, J., Takefuji, M., Aoyama, T., Suzuki, S., Tanaka, A., Matsubara, T., Murohara, T.

Circulation Journal Vol. 79 ( 7 ) page： 1542 - 1548 2015

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background:Until now, there have been few reports on the accuracy of in-stent restenosis (ISR) detection using high-definition computed tomography (HDCT). The purpose of this study was to assess ISR using HDCT with a new gemstone detector and to examine the diagnostic accuracy compared with invasive coronary angiography.Methods and Results:We evaluated 162 consecutive patients with 316 stents and the image quality (IQ) scores used to assess ISR, and analyzed whether stent strut thickness and diameter affected IQ score and assessability. In the 316 stents, 278 were diagnosed as assessable with HDCT (88.0%). IQ score for stent diameter ≥3 mm was significantly higher than that for stent diameter <3 mm, for stents with both thick struts ≥140 μm in thickness (mean IQ: 2.04±0.97 vs. 2.83±1.06, P<0.001) and thin struts <140 μm (mean IQ: 1.92±0.87 vs. 2.64±0.96, P=0.01). Assessability for stent diameter ≥3 mm was significantly higher than that for stent diameter <3 mm only for stents with thick struts (92.8% vs. 76.1%, P<0.001). Stent strut thickness, however, was not statistically significantly associated with either IQ score or assessability.Conclusions:In-stent lumens have high HDCT assessability, and HDCT is useful to evaluate thick-strut stents with diameter <3 mm.

DOI： 10.1253/circj.CJ-14-1344

Inverse association between diabetes and aortic dilatation in patients with advanced coronary artery disease Reviewed

Tanaka, A., Ishii, H., Oshima, H., Narita, Y., Kodama, A., Suzuki, S., Komori, K., Usui, A., Murohara, T.

Atherosclerosis Vol. 242 ( 1 ) page： 123 - 127 2015

Impact of low-grade albuminuria on left ventricular diastolic dysfunction Reviewed

Nagai, H., Suzuki, S., Ishii, H., Shibata, Y., Harata, S., Takayama, Y., Tatami, Y., Shimbo, Y., Osugi, N., Ota, T., Kawamura, Y., Tanaka, A., Takeshita, K., Murohara, T.

IJC Metabolic and Endocrine Vol. 6 page： 13 - 16 2015

Relation of airflow limitation and smoking status to carotid atherosclerosis in patients with coronary artery disease

Suzuki S., Ishii H., Shibata Y., Tatami Y., Osugi N., Ota T., Kawamura Y., Tanaka A., Murohara T.

EUROPEAN HEART JOURNAL Vol. 35 page： 902 - 902 2014.9

Impact of albuminuria on the incidence of peri-procedural myocardial injury in patients undergoing elective stent implantation

Suzuki S., Ishii H., Shibata Y., Tatami Y., Osugi N., Ota T., Kawamura Y., Tanaka A., Murohara T.

EUROPEAN HEART JOURNAL Vol. 35 page： 130 - 130 2014.9

Impact of albuminuria on the incidence of periprocedural myocardial injury in patients undergoing elective coronary stent implantation Reviewed

Osugi, N., Suzuki, S., Ishii, H., Yasuda, Y., Shibata, Y., Tatami, Y., Ota, T., Kawamura, Y., Okumura, S., Tanaka, A., Inoue, Y., Matsuo, S., Murohara, T.

American Journal of Cardiology Vol. 114 ( 1 ) page： 42 - 46 2014

Impact of chronic obstructive pulmonary disease on composition of left main coronary artery plaque with intermediate stenosis Reviewed

Kumagai, S., Ishii, H., Takashima, H., Waseda, K., Kurita, A., Ando, H., Gosho, M., Yoshikawa, D., Suzuki, S., Tanaka, A., Matsubara, T., Murohara, T., Amano, T.

International Journal of Cardiology Vol. 174 ( 3 ) page： 865 - 866 2014

Influence of the false lumen status on clinical outcomes in patients with acute type B aortic dissection Reviewed International journal

Tanaka, A., Sakakibara, M., Ishii, H., Hayashida, R., Jinno, Y., Okumura, S., Okada, K., Murohara, T.

Journal of Vascular Surgery Vol. 59 ( 2 ) page： 321 - 326 2014

Accelerated decline in renal function after acute myocardial infarction in patients with high low-density lipoprotein-cholesterol to high-density lipoprotein-cholesterol ratio Reviewed International journal

Okumura, S., Sakakibara, M., Hayashida, R., Jinno, Y., Tanaka, A., Okada, K., Hayashi, M., Ishii, H., Murohara, T.

Heart and Vessels Vol. 29 ( 1 ) page： 7 - 14 2014

Impact of serum bilirubin levels on carotid atherosclerosis in patients with coronary artery disease Reviewed

Tatami, Y., Suzuki, S., Ishii, H., Shibata, Y., Osugi, N., Ota, T., Kawamura, Y., Tanaka, A., Takeshita, K., Murohara, T.

IJC Metabolic and Endocrine Vol. 5 page： 24 - 27 2014

Elevated Fasting Glucose is an Important Risk Factor for Contrast-Induced Nephropathy in Non-Diabetic Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Okumura Satoshi, Sakakibara Masaki, Havashida Ryo, Tanaka Akihito, Jinno Yasushi, Okada Koji, Murohara Toyoaki

CIRCULATION Vol. 126 ( 21 ) 2012.11

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