Faculty Profiles - TANAKA Akihito

Papers - TANAKA Akihito

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Comparison of short and long term clinical outcomes according to status of the false lumen in patients with acute type B aortic dissection

Tanaka A., Sakakibara M., Hayashida R., Jinno Y., Okumura S., Okada K., Murohara T.

EUROPEAN HEART JOURNAL Vol. 33 page： 243 - 243 2012.8

Comparison of early outcomes after primary stenting in Japanese patients with acute myocardial infarction between clopidogrel and ticlopidine in concomitant use with proton-pump inhibitor Reviewed

Tanaka, A., Sakakibara, M., Okumura, S., Okada, K., Ishii, H., Murohara, T.

Journal of Cardiology Vol. 60 ( 1 ) page： 7 - 11 2012

Does N-acetylcysteine reduce the incidence of contrast-induced nephropathy and clinical events in patients undergoing primary angioplasty for acute myocardial infarction? Reviewed

Tanaka, A., Suzuki, Y., Suzuki, N., Hirai, T., Yasuda, N., Miki, K., Fujita, M., Tanaka, T.

Internal Medicine Vol. 50 ( 7 ) page： 673 - 677 2011

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

Objectives We examined oral N-acetylcysteine effects on contrast-induced nephropathy (CIN) and clinical events in patients undergoing primary angioplasty for acute myocardial infarction. Background Recent studies have reported that N-acetylcysteine reduces CIN and improves the clinical outcome in patients undergoing primary angioplasty. However, additional investigations are warranted to further support these findings. Methods We randomly assigned 76 patients undergoing primary angioplasty into two groups: 38 patients were assigned to N-acetylcysteine (NAC, 705 mg orally administration before and 12, 24, 36 hours after primary angioplasty), and 38 patients to placebo. CIN was defined as an increase in the serum creatinine concentration of 25 percent or more from baseline value within the 72-hour period after primary angioplasty. Results CIN occurred in 7 patients (9.2%). In the NAC group, the incidence of CIN tended to be lower than in the placebo group (NAC; 2/38; 5.3% vs. Placebo; 5/38; 13.2%, p=0.21). The composite endpoints such as death, acute renal failure requiring temporary renal replacement therapy, or need for mechanical ventilation did not occur in either group. Conclusion While N-acetylcysteine might have the possibility to reduce the incidence of contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction, the in-hospital mortality and morbidity were not significantly different between the two groups.

DOI： 10.2169/internalmedicine.50.4226

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Percutaneous coronary intervention with a virtual 2-Fr system Reviewed

Tanaka, A., Saito, S.

Catheterization and Cardiovascular Interventions Vol. 76 ( 5 ) page： 684 - 6 2010

Ability of dynamic chest radiography to identify left ventricular systolic dysfunction in heart failure. International journal

Hiroaki Hiraiwa, Shin Nagai, Ryota Ito, Kiyota Kondo, Shingo Kazama, Toru Kondo, Shiro Adachi, Kenji Furusawa, Akihito Tanaka, Ryota Morimoto, Takahiro Okumura, Toyoaki Murohara

The international journal of cardiovascular imaging 2025.1

Language：English Publishing type：Research paper (scientific journal)

Dynamic chest radiography (DCR) can estimate haemodynamic parameters in heart failure (HF). However, no studies have evaluated its ability to determine cardiac systolic function in HF. This experimental study investigates the correlation between left ventricular (LV) ejection fraction (LVEF) and DCR image parameters in HF. Ninety-one patients with acute HF (median age, 58 years; males, 75%) (cardiologist diagnosis using the Framingham criteria) underwent DCR and transthoracic echocardiography after treatment for the uncompensated phase of HF. The LV apex pixel value (PV) change was measured by DCR. Correlations between the PV change and LVEF, as well as sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of DCR, were evaluated. LVEF and LV apex PV change were correlated in all patients (R = 0.428, P < 0.001) and in patients with LVEF < 50% (n = 38; R = 0.355, P = 0.029), < 40% (n = 31; R = 0.343, P = 0.059), and < 30% (n = 23; R = 0.321, P = 0.135). There was no significant correlation for patients with LVEF ≥ 50% (n = 53; R = - 0.004, P = 0.980). The LV apex PV change rate cutoff values for identifying LVEF < 50%, < 40%, and < 30% were 9.3% (AUC: 0.761, sensitivity: 0.698, specificity: 0.789, P < 0.001), 5.5% (AUC: 0.765, sensitivity: 0.883, specificity: 0.645, P < 0.001), and 5.5% (AUC: 0.767, sensitivity: 0.838, specificity: 0.696, P < 0.001), respectively. DCR may be useful to identify LV systolic dysfunction based on LVEF in acute HF.

DOI： 10.1007/s10554-025-03332-x

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The Influence of Eicosapentaenoic Acid to Arachidonic Acid Ratio on Long-term Cardiovascular Events Following Percutaneous Coronary Intervention Reviewed

Kiyoshi Niwa, Akihito Tanaka, Hiroshi Funakubo, Satoshi Otsuka, Naoki Yoshioka, Nobutaka Kudo, Akihiro Tobe, Keisuke Sakakibara, Yusuke Miki, Takashi Kataoka, Kenji Furusawa, Hideki Ishii, Toyoaki Murohara

Internal Medicine Vol. 60 ( 24 ) page： 3865 - 3871 2021.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Internal Medicine

Objective The relationship between cardiovascular disease and the serum polyunsaturated fatty acid parameters has been reported. The aim of the present study was to investigate the association between the eicosapentaenoic acid and arachidonic acid (EPA/AA) ratio and long-term cardiovascular events in patients with coronary artery disease. Methods We identified a total of 831 patients who underwent percutaneous coronary intervention and whose EPA/AA ratio was available. The patients were divided into two groups according to their serum EPA/AA ratio (median, 0.29; interquartile range 0.19-0.47): those in the lower quartile of EPA/AA ratios (Low EPA/AA group; n=231) and all other subjects (High EPA/AA group; n=600). The primary endpoints included a composite of cardiovascular death, myocardial infarction, and ischemic stroke. Results Patients in the Low EPA/AA group were significantly younger (66.0±12.6 years vs. 69.9±9.3 years, p<0.001), current smokers (33.3% vs. 22.7%, p=0.002), and had a history of myocardial infarction (20.3% vs. 12.3%, p=0.003). During the follow-up (median, 1,206 days; interquartile range, 654-1,910 days), the occurrence of the primary endpoint was significantly higher in the Low EPA/AA group than in the High EPA/AA group. Of note, the rate of cardiovascular death was significantly higher in the Low EPA/AA group, and the rates of myocardial infarction and stroke tended to be higher. Conclusion A low EPA/AA ratio was associated with long-term adverse cardiovascular events in Japanese patients with coronary artery disease.

DOI： 10.2169/internalmedicine.7336-21

Incidental findings on computed tomography for preoperative assessment before transcatheter aortic valve implantation in Japanese patients Reviewed

Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Yusuke Miki, Kenji Furusawa, Sho Akita, Taro Fujii, Yoshinori Tsutsumi, Hideki Ishii, Shingo Iwano, Shinji Naganawa, Akihiko Usui, Toyoaki Murohara

Heart and Vessels Vol. 36 ( 12 ) page： 1911 - 1922 2021.12

High-output Heart Failure Caused by a Tumor-related Arteriovenous Fistula: A Case Report and Literature Review Reviewed

Akihiro Tobe, Akihito Tanaka, Satoya Yoshida, Toru Kondo, Ryota Morimoto, Kenji Furusawa, Takahiro Okumura, Yasuko K Bando, Hideki Ishii, Toyoaki Murohara

Internal Medicine Vol. 60 ( 18 ) page： 2979 - 2984 2021.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Internal Medicine

High-output heart failure caused by a tumor-related arteriovenous fistula in adults is a rare clinical condition. We herein report a case of high-output heart failure caused by an arteriovenous fistula associated with renal cell carcinoma and a literature review of 29 published cases to date. Renal cell carcinoma seems to be the most common underlying tumor. For the diagnosis, right heart catheterization and enhanced computed tomography (CT) are considered useful. The removal of the underlying tumor and arteriovenous fistula is the best treatment for heart failure.

DOI： 10.2169/internalmedicine.6962-20

Improvement in the nutritional status after transcatheter aortic valve implantation Reviewed

Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Sho Akita, Yusuke Miki, Kenji Furusawa, Hideki Ishii, Akihiko Usui, Toyoaki Murohara

Journal of Cardiology Vol. 78 ( 3 ) page： 250 - 254 2021.9

Worsening renal function after transcatheter aortic valve replacement and surgical aortic valve replacement Reviewed

Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Toshihiko Nishi, Yusuke Miki, Kenji Furusawa, Hideki Ishii, Akihiko Usui, Toyoaki Murohara

Heart and Vessels Vol. 36 ( 7 ) page： 1080 - 1087 2021.7

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media {LLC}

DOI： 10.1007/s00380-021-01778-2

Other Link： https://link.springer.com/article/10.1007/s00380-021-01778-2/fulltext.html

Regression of Electrocardiographic Left Ventricular Hypertrophy After Transcatheter Aortic Valve Implantation for Aortic Stenosis

Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Sho Akita, Taro Fujii, Yusuke Miki, Kenji Furusawa, Hideki Ishii, Akihiko Usui, Toyoaki Murohara

Circulation Journal Vol. 85 ( 7 ) page： 1093 - 1098 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Circulation Society

Background:The changes in electrocardiographic left ventricular hypertrophy (ECG-LVH) after transcatheter aortic valve implantation (TAVI) are not fully elucidated.Methods and Results:The study group included 64 patients who underwent TAVI for aortic stenosis. Their 12-lead ECGs before and at 2 days and 1, 6 and 12 months after TAVI were analyzed, and ECG-LVH was evaluated using various definitions. Values and prevalence of each ECG-LVH parameter significantly decreased between 1 and 6 months after TAVI. Values of ECG-LVH parameters decreased especially in patients with ECG-LVH at baseline.Conclusions:Regression of ECG-LVH was observed between 1 and 6 months after TAVI.

DOI： 10.1253/circj.cj-21-0354

The Mid-term Mortality and Mode of Death in Survivors with ST-elevation Myocardial Infarction Reviewed

Naoki Yoshioka, Kensuke Takagi, Akihito Tanaka, Yasuhiro Morita, Ruka Yoshida, Yasunori Kanzaki, Hiroaki Nagai, Naoki Watanabe, Ryota Yamauchi, Shotaro Komeyama, Hiroki Sugiyama, Kazuki Shimojo, Takuro Imaoka, Gaku Sakamoto, Takuma Ohi, Hiroki Goto, Hideki Ishii, Itsuro Morishima, Toyoaki Murohara

Internal Medicine Vol. 60 ( 11 ) page： 1665 - 1674 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Internal Medicine

Objective The popularity of primary percutaneous coronary intervention (p-PCI) for ST-elevation myocardial infarction (STEMI) has increased over the past decades. Despite improvements in in-hospital mortality rates, it is clinically important to investigate the prognoses after discharge. However, data on the mode of death and prognostic factors are limited. We analyzed these factors in a Japanese cohort in the modern p-PCI era. Methods Between January 2004 and December 2017, a total of 1,222 patients who underwent p-PCI within 24 hours from the onset of STEMI and were alive at discharge (mean age, 67.7 years old; men, 75.5%), were evaluated. The two-year mortality was analyzed using a Cox regression model, and the mode of death was evaluated. Results The rate of mortality at 2 years was 5.7%. Non-cardiac death was more frequent than cardiac death (62.6% vs. 37.4%). A Cox multivariate analysis identified the following as independent predictors of the 2-year mortality: hemoglobin (log-transformed) [adjusted hazard ratio (HR), 0.048; 95% confidence interval (CI), 0.008-0.29; p<0.001], age above 80 years old (adjusted HR, 2.26; 95% CI, 1.30-3.91; p=0.004), Killip class ≥II (adjusted HR, 1.99; 95% CI, 1.17-3.39; p=0.011), brain natriuretic peptide level (log-transformed) (adjusted HR, 1.47; 95% CI, 1.09-2.01; p=0.013), and body mass index (log-transformed) (adjusted HR, 0.16; 95% CI, 0.030-0.84; p=0.030). Conclusion This study demonstrated that the 2-year mortality was 5.7% in STEMI survivors after p-PCI. Non-cardiac death was more frequent than cardiac death. Compared to well-known clinical variables, angiographic findings did not have a significant influence on the mid-term mortality.

DOI： 10.2169/internalmedicine.6549-20

Ten-Year Mortality in Patients With ST-Elevation Myocardial Infarction Reviewed

Naoki Watanabe, Kensuke Takagi, Akihito Tanaka, Naoki Yoshioka, Yasuhiro Morita, Ruka Yoshida, Yasunori Kanzaki, Hiroaki Nagai, Ryota Yamauchi, Shotaro Komeyama, Hiroki Sugiyama, Kazuki Shimojo, Takuro Imaoka, Gaku Sakamoto, Takuma Ohi, Hiroki Goto, Takahiro Okumura, Hideki Ishii, Itsuro Morishima, Toyoaki Murohara

The American Journal of Cardiology Vol. 149 page： 9 - 15 2021.6

待機的経カテーテル大動脈弁置換術後患者の術後在院長期化の要因;術前握力の有用性 Reviewed

堀将也, 小林聖典, 高木大地, 徳田順之, 田中哲人, 碓氷章彦

心臓リハビリテーション Vol. 27 ( 2 ) page： 129 - 135 2021.6

Language：Japanese Publisher：(NPO)日本心臓リハビリテーション学会

【目的】待機的経カテーテル大動脈弁置換術(TAVI)後患者において、術後在院長期化の要因を検討する。【方法】2016年4月以降TAVI施行例119を対象として検討した。一般リスクに加え術前後に握力、歩行速度、認知機能を評価し、可能な限り術翌日より歩行を行うプロトコールで集中的理学療法を行った。術後在院の長期化を8日以上または転院例と定義し、危険因子を検討した。【結果】在院長期化群(n=51)では非長期化群(n=68)と比し術前握力低下例が多く(オッズ比=3.62、p=0.011)、non-TFアプローチが多く(オッズ比=20.6、p=0.009)、併発症としてのペースメーカー留置(オッズ比=15.9、p=0.010)が多かった。【結語】術前握力低下はTAVI後在院期間の長期化の独立危険因子であった。簡便に測定できる握力を評価に含めた理学療法計画の策定が有用であろう。(著者抄録)

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Perioperative D-dimer levels after transcatheter aortic valve replacement: Comparison of patients with and without anticoagulant therapy Reviewed

Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Toshihiko Nishi, Yusuke Miki, Kenji Furusawa, Hideki Ishii, Akihiko Usui, Toyoaki Murohara

Cardiology Journal Vol. 28 ( 1 ) page： 170 - 172 2021.2

Relationship between epicardial adipose tissue volume and coronary artery spasm Reviewed

Kataoka, T., Harada, K., Tanaka, A., Onishi, T., Matsunaga, S., Funakubo, H., Harada, K., Nagao, T., Shinoda, N., Marui, N., Niwa, K., Tashiro, H., Hitora, Y., Furusawa, K., Ishii, H., Amano, T., Murohara, T.

International Journal of Cardiology Vol. 324 page： 8 - 12 2021

Serial Images of Aortic Plaque Rupture During Transfemoral Transcatheter Aortic Valve Replacement Reviewed

Tobe, A., Tanaka, A., Tokuda, Y., Akita, S., Miki, Y., Furusawa, K., Ishii, H., Usui, A., Murohara, T.

JACC: Cardiovascular Interventions Vol. 13 ( 22 ) page： E203 - E204 2020.11

Multimodality imaging evaluation of saphenous vein graft peri-stent contrast staining enlargement Reviewed

Shibata Naoki, Sugiura Tsuyoshi, Tanaka Akihito, Shimizu Kiyokazu

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING Vol. 36 ( 11 ) page： 2105 - 2106 2020.11

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Cardiovascular Imaging

A patient with Takayasu arteritis who underwent CABG using a saphenous vein graft (SVG) experienced ventricular fibrillation due to total SVG occlusion. A drug-eluting stent was implanted; however, follow-up CAG demonstrated an advanced expansion of peri-stent contrast staining. Coronary computed tomography angiography revealed contrast media extending around the SVG. An intravascular ultrasound indicated a worsening stent malapposition and a significant positive remodeling.

DOI： 10.1007/s10554-020-01937-y

Impact of skeletal muscle mass on clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement Reviewed

Uchida Yasuhiro, Ishii Hideki, Tanaka Akihito, Yonekawa Jun, Satake Akinori, Makino Yuichiro, Suzuki Wataru, Kurobe Masanari, Mizutani Koji, Mizutani Yoshiaki, Fujimoto Masanobu, Ichimiya Hitoshi, Teramoto Chikao, Tamenishi Akinori, Okamoto Hiroshi, Watanabe Junji, Kanashiro Masaaki, Amano Tetsuya, Matsubara Tatsuaki, Ichimiya Satoshi, Murohara Toyoaki

CARDIOVASCULAR INTERVENTION AND THERAPEUTICS Vol. 36 ( 4 ) page： 514 - 522 2020.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Cardiovascular Intervention and Therapeutics

Low skeletal muscle mass is one of the components of sarcopenia. However, the prognostic impact of skeletal muscle mass on clinical outcomes in patients after transcatheter aortic valve replacement (TAVR) remains unclear. Therefore, we assessed the impact of skeletal muscle mass on future cardiovascular events in patients undergoing TAVR. We enrolled 71 consecutive patients who underwent TAVR for symptomatic severe aortic stenosis. We applied bilateral psoas muscles as an indicator of skeletal muscle mass. Psoas muscle volumes were measured from the origin of psoas at the level of the lumbar vertebrae to its insertion in the lesser trochanter on three-dimensional computed tomography datasets. Psoas muscle mass index (PMI) was calculated as psoas muscle volume/height2 (cm3/m2). According to the median value of PMIs (79.8 and 60.0 cm3/m2 for men and women), the enrolled patients were divided into two groups. During the follow-up, 11 (31.4%) patients in low PMI group and 4 (11.1%) in high PMI group experienced major adverse cardiovascular events (MACE) defined as a composite of death from any cause, myocardial infarction, heart failure hospitalization, and stroke. The proportion of MACE-free survival was significantly lower in low PMI group (log-rank P = 0.033), mainly due to the difference of hospital readmission for congestive heart failure. On multivariate Cox proportional hazard analysis, PMI remained an independent negative predictor of MACE [hazard ratio 0.95 (95% confidence interval 0.92–0.98, P = 0.002)]. In conclusion, low skeletal muscle mass independently predicted MACE in patients undergoing TAVR.

DOI： 10.1007/s12928-020-00725-8

Rotational Atherectomy for Severely Calcified Lesions in Patients With Left Ventricular Systolic Dysfunction: One-Year Outcomes From aSingle-Center Registry Analysis Reviewed

Yoshida, R., Ishii, H., Morishima, I., Tanaka, A., Takagi, K., Yoshioka, N., Morita, Y., Unno, K., Yoshida, Y., Tsuboi, H., Murohara, T.

Cardiovascular Revascularization Medicine Vol. 21 ( 10 ) page： 1220 - 1227 2020.10

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Papers - TANAKA Akihito